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Yr Athro Richard Stanton
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Richard Stanton
Athro Firoleg, Ysgol Meddygaeth
Trosolwyg
Rwy'n bennaeth ymchwil Heintiau yn yr Is-adran Heintiau ac Imiwnedd, yn Gyd-gyfarwyddwr Uned Firoleg Gymhwysol Cymru, ac yn Uwch Arweinydd Ymchwil yn Ymchwil Iechyd a Gofal Cymru. Rwy'n Athro o fewn y grŵp 'Imiwnoleg Firaol', a hefyd y grŵp 'Cytomegalofirws a Firoleg Adenofirws', o fewn yr is-adran Heintiau ac Imiwnedd. Mae fy ymchwil yn cwmpasu bioleg, imiwnoleg a diagnosis cytomegalofirws dynol (HCMV) yn ogystal â datblygu fectorau adenofirws ailgyfunol. Gellir gweld mwy o fanylion ar y dudalen Viral Immunology , a'r dudalen Cytomegalovirus and Adenovirus Virology . Rydym hefyd yn gweithio'n agos gyda'r grŵp Oncolytic Adenovirus Virology .
Gallwch hefyd ddod o hyd i wybodaeth am gyhoeddiadau ar Google Scholar a Web of Science.
Cyhoeddiad
2024
- Samer, C. et al. 2024. Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus–mediated disruption of the nonclassical MHC class I–related molecule MR1. Journal of Biological Chemistry 300(10), article number: 107748. (10.1016/j.jbc.2024.107748)
- Obergfäll, D. et al. 2024. Cyclin-dependent kinase 8 represents a positive regulator of cytomegalovirus replication and a novel host target for antiviral strategies. Pharmaceutics 16(9), article number: 1238. (10.3390/pharmaceutics16091238)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32(3), article number: 101308. (10.1016/j.omtm.2024.101308)
- Litvin, U., Wang, E. C., Stanton, R. J., Fielding, C. A. and Hughes, J. 2024. Evolution of the cytomegalovirus RL11 gene family in old world monkeys and great apes. Virus Evolution 10(1), article number: veae066. (10.1093/ve/veae066)
- Amratia, P. S., Kerr-Jones, L. E., Chapman, L., Marsden, M., Clement, M., Stanton, R. J. and Humphreys, I. R. 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15(8), article number: e03152-23. (10.1128/mbio.03152-23)
- Wesgate, R. et al. 2024. Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy. Journal of Hospital Infection 149, pp. 1-13. (10.1016/j.jhin.2023.12.021)
- Finkel, Y. et al. 2024. A virally encoded high-resolution screen of cytomegalovirus dependencies. Nature 630, pp. 712-719. (10.1038/s41586-024-07503-z)
- Hunter, L. M. et al. 2024. HCMV US2 co-opts TRC8 to degrade the endoplasmic reticulum-resident protein LMAN2L. Journal of General Virology 105(4), article number: 1980. (10.1099/jgv.0.001980)
- Li, H. et al. 2024. Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly. Cell Host & Microbe 32(4), pp. 466-478., article number: E11. (10.1016/j.chom.2024.02.013)
- Samer, C. et al. 2024. Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection. iScience 27(2), article number: 108801. (10.1016/j.isci.2024.108801)
- Hulin-Curtis, S. et al. 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43(6), article number: 114259. (10.1016/j.celrep.2024.114259)
2023
- Chowdhury, S. et al. 2023. Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors. Journal of General Virology 104(12), article number: 1929. (10.1099/jgv.0.001929)
- Vlachava, V. et al. 2023. HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation. Proceedings of the National Academy of Sciences 120(49), article number: e2309077120. (10.1073/pnas.2309077120)
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
- Duggan, K., Bentley, K., Stanton, R. J. and Maillard, J. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Semmes, E. C. et al. 2023. ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission. JCI Insight 8(13), article number: e167768. (10.1172/jci.insight.167768)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
- Lista, M. J. et al. 2023. Strain-dependent restriction of human cytomegalovirus by zinc finger antiviral proteins. Journal of Virology 97(3), article number: e01846-22. (10.1128/jvi.01846-22)
- Ashley, C. L. et al. 2023. Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation. Frontiers in Immunology 14 (10.3389/fimmu.2023.1107497)
2022
- Dangi, T. et al. 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132(23), article number: e162282. (10.1172/JCI162282)
- Saud, Z., Richards, C. A., Williams, G. and Stanton, R. J. 2022. Anti-viral organic coatings for high touch surfaces based on smart-release, Cu2+ containing pigments. Progress in Organic Coatings 172, article number: 107135. (10.1016/j.porgcoat.2022.107135)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13, article number: 5422. (10.1038/s41467-022-32985-8)
- Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
- Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13(1), article number: 5294. (10.1038/s41467-022-32587-4)
- Weiler, N., Sampaio, K. L., Stanton, R. J. and Sinzger, C. 2022. Combined knockdown of RL13 and UL128 for release of cell-free infectivity from recent HCMV isolates. Journal of Virological Methods 305, article number: 114537. (10.1016/j.jviromet.2022.114537)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75(1), pp. e82-e88., article number: ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Tizaoui, C. et al. 2022. Ozone for SARS-CoV-2 inactivation on surfaces and in liquid cell culture media. Journal of Hazardous Materials 428, article number: 128251. (10.1016/j.jhazmat.2022.128251)
- Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
- Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
2021
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13(12), article number: 2345. (10.3390/v13122345)
- Hyde, K. et al. 2021. Limited replication of human cytomegalovirus in a trophoblast cell line. Journal of General Virology 102(11), article number: 1683. (10.1099/jgv.0.001683)
- Lau, B. et al. 2021. Human cytomegalovirus RNA2.7 is required for upregulating multiple cellular genes to promote cell motility and viral spread late in lytic infection. Journal of Virology 95(20), article number: e00698-21. (10.1128/JVI.00698-21)
- Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
- Braun, B., Fischer, D., Laib Sampaio, K., Mezger, M., Stöhr, D., Stanton, R. J. and Sinzger, C. 2021. Peptide derivatives of platelet-derived growth factor receptor alpha inhibit cell-associated spread of human cytomegalovirus. Viruses 13(9), article number: 1780. (10.3390/v13091780)
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.07.23.453513
- Weiler, N. et al. 2021. Role of envelope glycoprotein complexes in cell-associated spread of human cytomegalovirus. Viruses 13(4), article number: 614. (10.3390/v13040614)
- Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
2020
- Fletcher-Etherington, A. et al. 2020. Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor. Proceedings of the National Academy of Sciences 117(31), pp. 18771 - 18779. (10.1073/pnas.2001887117)
- Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
- Houldcroft, C. J. et al. 2020. Assessing anti-HCMV cell mediated immune responses in transplant recipients and healthy controls using a novel functional assay. Frontiers in Cellular and Infection Microbiology 10, article number: 275. (10.3389/fcimb.2020.00275)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)
- Scurr, M. J. et al. 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research (10.1158/1078-0432.CCR-19-3087)
- Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)
- Taher, H. et al. 2020. In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome. PLoS Pathogens 16(11), article number: e1008666. (10.1371/journal.ppat.1008666)
2019
- Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)
2018
- Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
- Falk, J. et al. 2018. Large-scale screening of HCMV-seropositive blood donors indicates that HCMV effectively escapes from antibodies by cell-associated spread. Viruses 10(9), article number: 500. (10.3390/v10090500)
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Zhang, L., Zhou, M., Stanton, R., Kamil, J. and Ryckman, B. J. 2018. Expression levels of glycoprotein O (gO) vary between strains of human cytomegalovirus, influencing the assembly of gH/gL complexes and virion infectivity. Journal of Virology 92(15), article number: e00606-18. (10.1128/JVI.00606-18)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
2017
- Murrell, I. et al. 2017. The pentameric complex drives immunologically covert cell -cell transmission of wild-type human cytomegalovirus. Proceedings of the National Academy of Sciences 114(23), pp. 6104-6109. (10.1073/pnas.1704809114)
- Fielding, C. A. et al. 2017. Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation. eLife 6, article number: e22206. (10.7554/eLife.22206)
2016
- Assaifan, A. K., Lloyd, J. S., Samavat, S., Deganello, D., Stanton, R. J. and Teng, K. S. 2016. Nanotextured surface on flexographic printed ZnO thin films for low-cost non-Faradaic biosensors. ACS Applied Materials & Interfaces 8(49), pp. 33802-33810. (10.1021/acsami.6b11640)
- Laib Sampaio, K., Stegmann, C., Brizic, I., Adler, B., Stanton, R. J. and Sinzger, C. 2016. The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression. Journal of General Virology 97, pp. 1917-1927. (10.1099/jgv.0.000475)
- Murrell, I. et al. 2016. Genetic stability of BAC-deerived human cytomegalovirus during culture in vitro. Journal of Virology 90(8), pp. 3929-3943. (10.1128/JVI.02858-15)
- Karniely, S. et al. 2016. Human cytomegalovirus infection upregulates the mitochondrial transcription and translation machineries. mBio 7(2), article number: e00029-16. (10.1128/mBio.00029-16)
- Chen, K. C., Stanton, R. J., Banat, J. J. and Wills, M. R. 2016. Leukocyte Immunoglobulin-Like Receptor 1- expressing human natural killer cell subsets differentially recognize isolates of human cytomegalovirus through the viral MHC Class I homolog UL18. Journal of Virology 90(6), pp. 3123-3137. (10.1128/JVI.02614-15)
2015
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Uusi-Kerttula, H. et al. 2015. Incorporation of peptides targeting EGFR and FGFR1 into the adenoviral fibre knob domain, and their evaluation as targeted cancer therapies. Human Gene Therapy 26(5), pp. 320-329. (10.1089/hum.2015.015)
- Hsu, J. et al. 2015. Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141. PLoS Pathogens 11(4), article number: e1004811. (10.1371/journal.ppat.1004811)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11(2), article number: e1004641. (10.1371/journal.ppat.1004641)
2014
- Gabaev, I. et al. 2014. Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells. Journal of Virology 88(24), pp. 14326-14339. (10.1128/JVI.01691-14)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
2013
- Aicheler, R., Wang, E., Tomasec, P., Wilkinson, G. W. G. and Stanton, R. J. 2013. Potential for natural killer cell-mediated antibody-dependent cellular cytotoxicity for control of human cytomegalovirus. Antibodies 2(4), pp. 617-635. (10.3390/antib2040617)
- Murrell, I., Tomasec, P., Wilkie, G. S., Dargan, D. J., Davison, A. J. and Stanton, R. J. 2013. Impact of sequence variation in the UL128 locus on production of human cytomegalovirus in fibroblast and epithelial cells. Journal of Virology 87(19), pp. 10489-10500. (10.1128/JVI.01546-13)
- Aicheler, R. J. and Stanton, R. J. 2013. Functional NK cell cytotoxicity assays against virus infected cells. In: Bailer, S. M. and Lieber, D. eds. Virus-Host Interactions., Vol. 1064. Methods in Molecular Biology Springer, pp. 275-287., (10.1007/978-1-62703-601-6_20)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
2012
- Fielding, C. A. et al. 2012. A novel human cytomegalovirus gene function targets the natural killer cell activating ligand MICA for lysosomal degradation [Abstract]. Immunology 137(S1), pp. 154. (10.1111/imm.12001)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
2011
- Gabaev, I. et al. 2011. The human cytomegalovirus ul11 protein interacts with the receptor tyrosine phosphatase cd45, resulting in functional paralysis of t cells. PLoS Pathogens 7(12), article number: e1002432. (10.1371/journal.ppat.1002432)
2010
- Stanton, R. J. et al. 2010. Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication. Journal of Clinical Investigation 120(9), pp. 3191-3208. (10.1172/JCI42955)
- Prod'homme, V. et al. 2010. Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112. Journal of General Virology 91(8), pp. 2034-2039. (10.1099/vir.0.021931-0)
- Dargan, D. J. et al. 2010. Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture. Journal of General Virology 91(6), pp. 1535-1546. (10.1099/vir.0.018994-0)
2008
- Stanton, R. J., McSharry, B. P., Armstrong, M. L., Tomasec, P. and Wilkinson, G. W. G. 2008. Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function. Biotechniques 45(6), pp. 659-668.
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
2007
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
- Tomasec, P. et al. 2007. Adenovirus vector delivery stimulates natural killer cell recognition. Journal of General Virology 88(4), pp. 1103-1108. (10.1099/vir.0.82685-0)
2005
- Stanton, R. J., Westmoreland, D., Fox, J. D., Davison, A. J. and Wilkinson, G. W. G. 2005. Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients. Journal of Medical Virology 75(1), pp. 42-46. (10.1002/jmv.20235)
2003
- Stanton, R. J., Wilkinson, G. W. G. and Fox, J. D. 2003. Analysis of human herpesvirus-6 IE1 sequence variation in clinical samples. Journal of Medical Virology 71(4), pp. 578-584. (10.1002/jmv.10508)
Articles
- Samer, C. et al. 2024. Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus–mediated disruption of the nonclassical MHC class I–related molecule MR1. Journal of Biological Chemistry 300(10), article number: 107748. (10.1016/j.jbc.2024.107748)
- Obergfäll, D. et al. 2024. Cyclin-dependent kinase 8 represents a positive regulator of cytomegalovirus replication and a novel host target for antiviral strategies. Pharmaceutics 16(9), article number: 1238. (10.3390/pharmaceutics16091238)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32(3), article number: 101308. (10.1016/j.omtm.2024.101308)
- Litvin, U., Wang, E. C., Stanton, R. J., Fielding, C. A. and Hughes, J. 2024. Evolution of the cytomegalovirus RL11 gene family in old world monkeys and great apes. Virus Evolution 10(1), article number: veae066. (10.1093/ve/veae066)
- Amratia, P. S., Kerr-Jones, L. E., Chapman, L., Marsden, M., Clement, M., Stanton, R. J. and Humphreys, I. R. 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15(8), article number: e03152-23. (10.1128/mbio.03152-23)
- Wesgate, R. et al. 2024. Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy. Journal of Hospital Infection 149, pp. 1-13. (10.1016/j.jhin.2023.12.021)
- Finkel, Y. et al. 2024. A virally encoded high-resolution screen of cytomegalovirus dependencies. Nature 630, pp. 712-719. (10.1038/s41586-024-07503-z)
- Hunter, L. M. et al. 2024. HCMV US2 co-opts TRC8 to degrade the endoplasmic reticulum-resident protein LMAN2L. Journal of General Virology 105(4), article number: 1980. (10.1099/jgv.0.001980)
- Li, H. et al. 2024. Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly. Cell Host & Microbe 32(4), pp. 466-478., article number: E11. (10.1016/j.chom.2024.02.013)
- Samer, C. et al. 2024. Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection. iScience 27(2), article number: 108801. (10.1016/j.isci.2024.108801)
- Hulin-Curtis, S. et al. 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43(6), article number: 114259. (10.1016/j.celrep.2024.114259)
- Chowdhury, S. et al. 2023. Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors. Journal of General Virology 104(12), article number: 1929. (10.1099/jgv.0.001929)
- Vlachava, V. et al. 2023. HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation. Proceedings of the National Academy of Sciences 120(49), article number: e2309077120. (10.1073/pnas.2309077120)
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
- Duggan, K., Bentley, K., Stanton, R. J. and Maillard, J. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Semmes, E. C. et al. 2023. ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission. JCI Insight 8(13), article number: e167768. (10.1172/jci.insight.167768)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
- Lista, M. J. et al. 2023. Strain-dependent restriction of human cytomegalovirus by zinc finger antiviral proteins. Journal of Virology 97(3), article number: e01846-22. (10.1128/jvi.01846-22)
- Ashley, C. L. et al. 2023. Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation. Frontiers in Immunology 14 (10.3389/fimmu.2023.1107497)
- Dangi, T. et al. 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132(23), article number: e162282. (10.1172/JCI162282)
- Saud, Z., Richards, C. A., Williams, G. and Stanton, R. J. 2022. Anti-viral organic coatings for high touch surfaces based on smart-release, Cu2+ containing pigments. Progress in Organic Coatings 172, article number: 107135. (10.1016/j.porgcoat.2022.107135)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13, article number: 5422. (10.1038/s41467-022-32985-8)
- Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
- Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13(1), article number: 5294. (10.1038/s41467-022-32587-4)
- Weiler, N., Sampaio, K. L., Stanton, R. J. and Sinzger, C. 2022. Combined knockdown of RL13 and UL128 for release of cell-free infectivity from recent HCMV isolates. Journal of Virological Methods 305, article number: 114537. (10.1016/j.jviromet.2022.114537)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75(1), pp. e82-e88., article number: ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Tizaoui, C. et al. 2022. Ozone for SARS-CoV-2 inactivation on surfaces and in liquid cell culture media. Journal of Hazardous Materials 428, article number: 128251. (10.1016/j.jhazmat.2022.128251)
- Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
- Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13(12), article number: 2345. (10.3390/v13122345)
- Hyde, K. et al. 2021. Limited replication of human cytomegalovirus in a trophoblast cell line. Journal of General Virology 102(11), article number: 1683. (10.1099/jgv.0.001683)
- Lau, B. et al. 2021. Human cytomegalovirus RNA2.7 is required for upregulating multiple cellular genes to promote cell motility and viral spread late in lytic infection. Journal of Virology 95(20), article number: e00698-21. (10.1128/JVI.00698-21)
- Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
- Braun, B., Fischer, D., Laib Sampaio, K., Mezger, M., Stöhr, D., Stanton, R. J. and Sinzger, C. 2021. Peptide derivatives of platelet-derived growth factor receptor alpha inhibit cell-associated spread of human cytomegalovirus. Viruses 13(9), article number: 1780. (10.3390/v13091780)
- Weiler, N. et al. 2021. Role of envelope glycoprotein complexes in cell-associated spread of human cytomegalovirus. Viruses 13(4), article number: 614. (10.3390/v13040614)
- Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
- Fletcher-Etherington, A. et al. 2020. Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor. Proceedings of the National Academy of Sciences 117(31), pp. 18771 - 18779. (10.1073/pnas.2001887117)
- Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
- Houldcroft, C. J. et al. 2020. Assessing anti-HCMV cell mediated immune responses in transplant recipients and healthy controls using a novel functional assay. Frontiers in Cellular and Infection Microbiology 10, article number: 275. (10.3389/fcimb.2020.00275)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)
- Scurr, M. J. et al. 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research (10.1158/1078-0432.CCR-19-3087)
- Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)
- Taher, H. et al. 2020. In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome. PLoS Pathogens 16(11), article number: e1008666. (10.1371/journal.ppat.1008666)
- Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)
- Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
- Falk, J. et al. 2018. Large-scale screening of HCMV-seropositive blood donors indicates that HCMV effectively escapes from antibodies by cell-associated spread. Viruses 10(9), article number: 500. (10.3390/v10090500)
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Zhang, L., Zhou, M., Stanton, R., Kamil, J. and Ryckman, B. J. 2018. Expression levels of glycoprotein O (gO) vary between strains of human cytomegalovirus, influencing the assembly of gH/gL complexes and virion infectivity. Journal of Virology 92(15), article number: e00606-18. (10.1128/JVI.00606-18)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
- Murrell, I. et al. 2017. The pentameric complex drives immunologically covert cell -cell transmission of wild-type human cytomegalovirus. Proceedings of the National Academy of Sciences 114(23), pp. 6104-6109. (10.1073/pnas.1704809114)
- Fielding, C. A. et al. 2017. Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation. eLife 6, article number: e22206. (10.7554/eLife.22206)
- Assaifan, A. K., Lloyd, J. S., Samavat, S., Deganello, D., Stanton, R. J. and Teng, K. S. 2016. Nanotextured surface on flexographic printed ZnO thin films for low-cost non-Faradaic biosensors. ACS Applied Materials & Interfaces 8(49), pp. 33802-33810. (10.1021/acsami.6b11640)
- Laib Sampaio, K., Stegmann, C., Brizic, I., Adler, B., Stanton, R. J. and Sinzger, C. 2016. The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression. Journal of General Virology 97, pp. 1917-1927. (10.1099/jgv.0.000475)
- Murrell, I. et al. 2016. Genetic stability of BAC-deerived human cytomegalovirus during culture in vitro. Journal of Virology 90(8), pp. 3929-3943. (10.1128/JVI.02858-15)
- Karniely, S. et al. 2016. Human cytomegalovirus infection upregulates the mitochondrial transcription and translation machineries. mBio 7(2), article number: e00029-16. (10.1128/mBio.00029-16)
- Chen, K. C., Stanton, R. J., Banat, J. J. and Wills, M. R. 2016. Leukocyte Immunoglobulin-Like Receptor 1- expressing human natural killer cell subsets differentially recognize isolates of human cytomegalovirus through the viral MHC Class I homolog UL18. Journal of Virology 90(6), pp. 3123-3137. (10.1128/JVI.02614-15)
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Uusi-Kerttula, H. et al. 2015. Incorporation of peptides targeting EGFR and FGFR1 into the adenoviral fibre knob domain, and their evaluation as targeted cancer therapies. Human Gene Therapy 26(5), pp. 320-329. (10.1089/hum.2015.015)
- Hsu, J. et al. 2015. Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141. PLoS Pathogens 11(4), article number: e1004811. (10.1371/journal.ppat.1004811)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11(2), article number: e1004641. (10.1371/journal.ppat.1004641)
- Gabaev, I. et al. 2014. Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells. Journal of Virology 88(24), pp. 14326-14339. (10.1128/JVI.01691-14)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
- Aicheler, R., Wang, E., Tomasec, P., Wilkinson, G. W. G. and Stanton, R. J. 2013. Potential for natural killer cell-mediated antibody-dependent cellular cytotoxicity for control of human cytomegalovirus. Antibodies 2(4), pp. 617-635. (10.3390/antib2040617)
- Murrell, I., Tomasec, P., Wilkie, G. S., Dargan, D. J., Davison, A. J. and Stanton, R. J. 2013. Impact of sequence variation in the UL128 locus on production of human cytomegalovirus in fibroblast and epithelial cells. Journal of Virology 87(19), pp. 10489-10500. (10.1128/JVI.01546-13)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
- Fielding, C. A. et al. 2012. A novel human cytomegalovirus gene function targets the natural killer cell activating ligand MICA for lysosomal degradation [Abstract]. Immunology 137(S1), pp. 154. (10.1111/imm.12001)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
- Gabaev, I. et al. 2011. The human cytomegalovirus ul11 protein interacts with the receptor tyrosine phosphatase cd45, resulting in functional paralysis of t cells. PLoS Pathogens 7(12), article number: e1002432. (10.1371/journal.ppat.1002432)
- Stanton, R. J. et al. 2010. Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication. Journal of Clinical Investigation 120(9), pp. 3191-3208. (10.1172/JCI42955)
- Prod'homme, V. et al. 2010. Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112. Journal of General Virology 91(8), pp. 2034-2039. (10.1099/vir.0.021931-0)
- Dargan, D. J. et al. 2010. Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture. Journal of General Virology 91(6), pp. 1535-1546. (10.1099/vir.0.018994-0)
- Stanton, R. J., McSharry, B. P., Armstrong, M. L., Tomasec, P. and Wilkinson, G. W. G. 2008. Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function. Biotechniques 45(6), pp. 659-668.
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
- Tomasec, P. et al. 2007. Adenovirus vector delivery stimulates natural killer cell recognition. Journal of General Virology 88(4), pp. 1103-1108. (10.1099/vir.0.82685-0)
- Stanton, R. J., Westmoreland, D., Fox, J. D., Davison, A. J. and Wilkinson, G. W. G. 2005. Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients. Journal of Medical Virology 75(1), pp. 42-46. (10.1002/jmv.20235)
- Stanton, R. J., Wilkinson, G. W. G. and Fox, J. D. 2003. Analysis of human herpesvirus-6 IE1 sequence variation in clinical samples. Journal of Medical Virology 71(4), pp. 578-584. (10.1002/jmv.10508)
Book sections
- Aicheler, R. J. and Stanton, R. J. 2013. Functional NK cell cytotoxicity assays against virus infected cells. In: Bailer, S. M. and Lieber, D. eds. Virus-Host Interactions., Vol. 1064. Methods in Molecular Biology Springer, pp. 275-287., (10.1007/978-1-62703-601-6_20)
Websites
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.07.23.453513
Ymchwil
My research relates to the biology, immunology and diagnosis of human cytomegalovirus (HCMV), as well as the development of recombinant Adenovirus vectors. Please see Viral Immunology, Cytomegalovirus and Adenovirus Virology and Oncolytic Adenovirus Virology for further details. You can also find publication information on ResearcherID, Researchgate and Google Scholar .
Addysgu
Fi yw'r arweinydd ar gyfer addysgu Firoleg yn y Radd Feddygol. Rwy'n darlithio ar Imiwnoleg a firoleg, ac yn rhedeg sesiynau ymarferol a thiwtorialau firoleg. Rwyf hefyd yn mynd â myfyrwyr ar gyfer prosiectau labordy ar wahanol adegau drwy gydol y cwrs. O fewn y graddau BSc a Ffarmacoleg rhyng-gyfrifedig, rwy'n farciwr cwrs ar gyfer cyflwyniadau myfyrwyr o bapurau gwyddonol, marcio cyflwyniadau myfyrwyr o'u prosiectau ymchwil, ac yn rhedeg prosiectau reseach mewn labordy. Rwyf hefyd yn mynd â myfyrwyr o gyrsiau eraill sy'n dymuno ymgymryd â blwyddyn hyfforddi broffesiynol mewn labordy.
O fewn ein MSc Imiwnoleg Glinigol Gymhwysol ac Arbrofol, rwy'n addysgu ar Firoleg, imiwnoleg celloedd B, a Proteomeg.
Bywgraffiad
Trosolwg o'r gyrfa
- 2025-presennol: Uwch Arweinydd Ymchwil, Ymchwil Iechyd a Gofal Cymru
- 2025-presennol: Cyd-gyfarwyddwr Uned Firoleg Gymhwysol Cymru
- 2022-presennol: Pennaeth Heintiau, Ysgol Feddygaeth Prifysgol Caerdydd
- 2021-presennol: Athro mewn Firoleg, Ysgol Feddygaeth Prifysgol Caerdydd
- 2018-2021: Darllenydd mewn Microbioleg, Ysgol Feddygaeth Prifysgol Caerdydd.
- 2015-2018: Uwch Ddarlithydd mewn Microbioleg, Ysgol Feddygaeth Prifysgol Caerdydd.
- 2010-1015: Darlithydd mewn Microbioleg, Ysgol Feddygaeth Prifysgol Caerdydd.
- 2004-2010: Ymchwilydd Ôl-ddoethurol, Ysgol Feddygaeth Prifysgol Caerdydd
- 2003-2004: Ymchwilydd Ôl-ddoethurol, Coleg Meddygaeth Prifysgol Cymru
- 2002-2003: Cynorthwy-ydd Ymchwil, Coleg Meddygaeth Prifysgol Cymru
- 1997-1998: Lleoliad Hyfforddiant Diwydiannol, Bacterioleg, Gwasanaeth Labordy Iechyd y Cyhoedd
Addysg a Chymwysterau
- 1999-2002: PhD Firoleg, Coleg Meddygaeth Prifysgol Cymru
- 1999-2000: Diploma mewn Dulliau Biofeddygol, Coleg Meddygaeth Prifysgol Cymru
- 1995-1999: BSc (Anrh) Microbioleg, Coleg Prifysgol Cymru Caerdydd
Aelodaethau proffesiynol
- Cymdeithas Microbioleg
- Cymdeithas America ar gyfer Microbioleg
- Cymdeithas Imiwnoleg Prydain
Pwyllgorau ac adolygu
- Aelod o 'Grŵp Cynghori Gwobr Darganfod' Ymddiriedolaeth Wellcome
- Aelod o bwyllgor Grant Cymrodoriaeth Ymchwil Gofal Iechyd Cymru
- Aelod o'r grŵp 'Arloesi i Effaith'
- Aelod o baneli arfarnu ar gyfer trosglwyddiadau blwyddyn 1af/2nd/3ydd o fyfyrwyr PhD yn y Sefydliad Heintiau ac Imiwnedd
- Golygydd PNAS Nexus
- Golygydd ar gyfer Pathogenau PLoS
- Golygydd ar gyfer Adroddiadau Gwyddonol
- Aelod o'r Bwrdd Golygyddol ar gyfer y Journal of General Virology
Contact Details
Themâu ymchwil
Arbenigeddau
- Firoleg
- Imiwnoleg
