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Peter Taylor
BSC, MBChB, MSc, PhD, FRCP
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Peter Taylor
Uwch Ddarlithydd Anrhydeddus
Trosolwyg
Rwy'n gwneud ymchwil mewn epidemioleg a threialon clinigol mewn clefyd thyroid a diabetes math 1.
Clefyd thyroid
Mae fy ymchwil yn canolbwyntio ar ganlyniadau sut mae amrywiad cymedrol mewn statws thyroid yn dylanwadu ar ganlyniadau iechyd allweddol. Mae'r gwaith hwn yn cwmpasu pedair thema yn fras.
1) amnewid hormonau thyroid, gan gynnwys dewisiadau amgen i fonotherapi LT4 fel LT3 hirdymor.
2) Pathogenesis o Orbitopathi Graves (clefyd y llygad thyroid) a threialon clinigol i wella ei ganlyniad.
3) Statws thyroid yn ystod beichiogrwydd a'i berthynas â chanlyniadau obstetreg allweddol. Mae fy ngwaith yn cynnwys sut i wneud y gorau o driniaeth ac a ddylem sgrinio ar gyfer clefyd y thyroid yn ystod beichiogrwydd.
4) Trothwyon triniaeth mewn hypothyroidiaeth ac a ddylid gwneud hyn yn individuliased.
Mae fy ymchwil epidemioleg hefyd yn ymestyn i effaith statws ïodin (sy'n gysylltiedig yn agos â ffisioleg thyroid) ar ganlyniadau iechyd.
Math 1 Diabetes
Mae'r gwaith hwn yn canolbwyntio ar y ffordd orau o ddefnyddio imiwnotherapi risg isel mewn unigolion sydd mewn perygl o ddatblygu neu â diabetes math 1 newydd o ddechrau. Yn ogystal â bod yn rhan o dreialon clinigol, rwy'n ymchwilio pa farcwyr sydd orau wrth bennu swyddogaeth celloedd beta gan gynnwys defnyddio dysgu peiriannau o ddata monitro glwcos parhaus (CGM).
Cyhoeddiad
2026
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- Heald, A. et al., 2026. P449 - LBA_ECE_1231 - Does the use of reflex testing for thyroid function tests (TFTs) –only testing FT4 when TSH is out of range—effect the prescribing of levothyroxine (LT4)? an England wide investigation [Abstract]. European journal of endocrinology 195 (S1) 568. (10.1093/ejendo/lvag096.568)
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- Heald, A. et al., 2026. A single centre study to describe the changes in serum testosterone concentration following application of testosterone gel in post‐menopausal women with hypoactive sexual desire disorder (HSSD) already receiving this as part of usual care in conjunction with oestrogen‐containing hormone replacement treatment (HRT). Clinical Endocrinology 105 (1), pp.77-84. (10.1111/cen.70119)
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- Taylor, P. N. et al. 2026. Relationship between participant-reported outcomes, residual beta cell function and metabolic parameters in youth with newly diagnosed type 1 diabetes. Diabetologia (10.1007/s00125-026-06798-z)
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- Dunseath, G. J. et al., 2026. Serial dried blood spot c-peptide sampling, but not urine c-peptide-to-creatinine ratio, detects early preservation of β-cell function in new-onset type 1 diabetes: experience from the USTEKID trial. Diabetes Care 49 (7), pp.1-8. (10.2337/dc25-2896)
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2025
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2024
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- Bianco, A. C. and Taylor, P. N. 2024. Optimizing the treatment of hypothyroidism. Nature Reviews Endocrinology 20 , pp.379-380. (10.1038/s41574-024-00989-7)
- Heald, A. H. et al., 2024. Liothyronine (LT3) prescribing in England: Are cost constraints inhibiting guideline implementation?. Clinical Endocrinology 101 (1), pp.62-68. (10.1111/cen.15061)
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2023
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- Taylor, P. N. et al. 2023. C-peptide and metabolic outcomes in trials of disease modifying therapy in new-onset type 1 diabetes: an individual participant meta-analysis. The Lancet Diabetes & Endocrinology 11 (12), pp.915-925. (10.1016/S2213-8587(23)00267-X)
- Allen, L. A. et al. 2023. Maternal type 1 diabetes and relative protection against offspring transmission. Lancet Diabetes and Endocrinology 11 (10), pp.755-767. (10.1016/S2213-8587(23)00190-0)
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108 (10), pp.2615-2625. (10.1210/clinem/dgad084)
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- Biscarini, F. et al. 2023. Gut microbiome associated with Graves disease and Graves orbitopathy: the INDIGO Multicenter European Study. The Journal of Clinical Endocrinology & Metabolism 108 (8), pp.2065-2077. (10.1210/clinem/dgad030)
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- Conrad, N. et al., 2023. Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK. The Lancet 401 (10391), pp.1878-1890. (10.1016/S0140-6736(23)00457-9)
- Velasco, I. et al., 2023. Iodine supplementation for preventing iodine deficiency disorders in children and adolescents. Cochrane Library 2023 (4)(10.1002/14651858.CD014475)
- Taylor, P. et al. 2023. Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice. Thyroid Research 16 7. (10.1186/s13044-023-00149-5)
2022
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- Panagiotou, G. et al., 2022. Late offspring effects of antenatal thyroid screening. British Medical Bulletin 143 (1), pp.16-29. (10.1093/bmb/ldac018)
- Taylor, P. N. et al. 2022. Prescribing costs of hypoglycaemic agents and associations with metabolic control in Wales; a national analysis of primary care data. Diabetic Medicine 39 (9) e14908. (10.1111/dme.14908)
- Taylor, P. 2022. S-09-01 Thyroid hormones, pregnancy and offspring development in humans and correlation to animals. Toxicology Letters 368 , pp.S27-S28. (10.1016/j.toxlet.2022.07.092)
- Taylor, P. et al. 2022. Vaccine‐induced thrombosis and thrombocytopenia with bilateral adrenal haemorrhage [Letter]. Clinical Endocrinology 97 (1), pp.26-27. (10.1111/cen.14548)
- Agrawal, M. et al., 2022. Antithyroid drug therapy in pregnancy and risk of congenital anomalies: Systematic review and meta-analysis. Clinical Endocrinology 96 (6), pp.857-868. (10.1111/cen.14646)
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- Shafti, M. et al., 2022. The role of secondary psychopathy and emotional dysregulation in forensic mental health service users? Dual-harm. Presented at: Royal College of Psychiatrists Faculty of Forensic Psychiatry Conference Online 02-04 March 2022.
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2021
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2020
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- Ved, R. et al. 2020. Vitamin D deficiency is endemic in neurosurgical patients and is associated with a longer length of inpatient stay. Endocrinology, Diabetes and Metabolism 3 (1) e00097. (10.1002/edm2.97)
- Velasco, I. et al., 2020. Iodine status, thyroid function, and birthweight: a complex relationship in high-risk pregnancies. Journal of Clinical Medicine 9 (1) 177. (10.3390/jcm9010177)
2019
- Taylor, P. N. et al. 2019. New insights into the pathogenesis and nonsurgical management of Graves orbitopathy. Nature Reviews Endocrinology 16 (2), pp.104-116. (10.1038/s41574-019-0305-4)
- Choudhury, M. et al. 2019. Association between HbA1c and the development of cystic fibrosis‐related diabetes. Diabetic Medicine 36 (10), pp.1251-1255. (10.1111/dme.13912)
- Taylor, P. N. et al. 2019. Combination thyroid hormone replacement; knowns and unknowns. Frontiers in Endocrinology 10 706. (10.3389/fendo.2019.00706)
- Taylor, P. N. and Lazarus, J. H. 2019. Hypothyroidism in pregnancy. Endocrinology and Metabolism Clinics of North America 48 (3), pp.547-556. (10.1016/j.ecl.2019.05.010)
- Medici, M. et al., 2019. The importance of high-quality mendelian randomisation studies for clinical thyroidology. Lancet Diabetes and Endocrinology 7 (9), pp.665-667. (10.1016/S2213-8587(19)30145-7)
- Taylor, P. and Bianco, A. C. 2019. Urgent need for further research in subclinical hypothyroidism. Nature Reviews Endocrinology 15 (9), pp.503-504. (10.1038/s41574-019-0239-x)
- Korevaar, T. I. M. et al., 2019. Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis. Journal of the American Medical Association 322 (7), pp.632-641. (10.1001/jama.2019.10931)
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- Razvi, S. , Korevaar, T. I. and Taylor, P. 2019. Trends, determinants, and associations of treated hypothyroidism in the United Kingdom, 2005-2014. Thyroid 29 (2), pp.174-182. (10.1089/thy.2018.0251)
- Das, G. et al., 2019. Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes. Annals of Clinical Biochemistry 56 (1), pp.155-162. (10.1177/0004563218797979)
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2018
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- Muller, I. , Taylor, P. and Lazarus, J. 2018. Thyroid function in pregnancy. Annals of Thyroid (10.21037/aot.2018.10.05)
- Just, S. A. et al., 2018. Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe. RMD Open 4 (2), pp.e000799. (10.1136/rmdopen-2018-000799)
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- Okosieme, O. , Khan, I. and Taylor, P. N. 2018. Preconception management of thyroid dysfunction. Clinical Endocrinology 89 (3), pp.269-279. (10.1111/cen.13731)
- Bakhsh, A. D. et al. 2018. An InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goiter. Thyroid 28 (7), pp.891-901. (10.1089/thy.2017.0312)
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- Taylor, P. N. and Davies, J. S. 2018. A review of the growing risk of vitamin D toxicity from inappropriate practice. British Journal of Clinical Pharmacology 84 (6), pp.1121-1127. (10.1111/bcp.13573)
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- Hales, C. et al. 2018. Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition. Journal of Clinical Endocrinology and Metabolism 103 (4), pp.1583-1591. (10.1210/jc.2017-02378)
- Rajendram, R. et al., 2018. Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial. Lancet Diabetes and Endocrinology 6 (4), pp.299-309. (10.1016/S2213-8587(18)30021-4)
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- Taylor, P. 2018. Common variation in thyroid hormone status; effects on key health outcomes. PhD Thesis , Cardiff University.
2017
- Taylor, P. et al. 2017. Cerebral salt wasting following traumatic brain injury. Endocrinology, Diabetes & Metabolism Case Reports (10.1530/EDM-16-0142)
- Taylor, P. N. et al. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102 (7), pp.2508-2515. (10.1210/jc.2016-3605)
- Dew, R. et al., 2017. Patients' attitudes and perceptions towards treatment of hypothyroidism in general practice: an in-depth qualitative interview study. BJGP Open BJGP-2017-0125. (10.3399/bjgpopen17X100977)
- Lazarus, J. et al., 2017. Iodine in malt whiskey: A preliminary analysis. Thyroid 27 (3), pp.477-478. (10.1089/thy.2016.0596)
2016
- Korevaar, T. I. et al., 2016. An invitation to join the consortium on thyroid and pregnancy [Letter]. European Thyroid Journal 5 (4), pp.277. (10.1159/000452331)
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- Tabasum, A. et al., 2016. Thyroid antibody-negative euthyroid Graves' ophthalmopathy. Endocrinology, Diabetes & Metabolism Case Reports 2016 (1) EDM160008. (10.1530/EDM-16-0008)
- Witczak, J. et al. 2016. Predicting malignancy in thyroid nodules: feasibility of a predictive model integrating clinical, biochemical, and ultrasound characteristics. Thyroid Research 9 (1) 4. (10.1186/s13044-016-0033-y)
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- Lazarus, J. and Taylor, P. 2016. Hypothyroxinaemia and brain development. Acta Endocrinologica 12 (1), pp.1-6. (10.4183/aeb.2016.1)
2015
- Taylor, P. et al. 2015. Weekly intramuscular injection of Levothyroxine following Myxoedema: a practical solution to an old crisis. Case Reports in Endocrinology 2015 169194. (10.1155/2015/169194)
- Stacey, M. J. et al., 2015. Susceptibility to exertional heat illness and hospitalisation risk in UK military personnel. BMJ Open Sport & Exercise Medicine 1 (1), pp.e000055. (10.1136/bmjsem-2015-000055)
- Taylor, P. N. et al. 2015. Should all women be screened for thyroid dysfunction in pregnancy?. Women's Health 11 (3), pp.295-307. (10.2217/whe.15.7)
- Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6 5681. (10.1038/ncomms6681)
2014
- Taylor, P. N. et al. 2014. Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the controlled antenatal thyroid study. Journal of Clinical Endocrinology and Metabolism 99 (11), pp.4291-4298. (10.1210/jc.2014-1901)
- Taylor, P. et al. 2014. TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study. Journal of Clinical Endocrinology & Metabolism 99 (10), pp.3895-3902. (10.1210/jc.2014-1954)
- Taylor, P. et al. 2014. Therapy of endocrine disease: impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. European Journal of Endocrinology 170 (1), pp.R1-R15. (10.1530/EJE-13-0651)
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2013
- Draman, M. et al. 2013. Effects of Prostaglandin F2a on adipocyte biology relevant to graves' orbitopathy. Thyroid: official journal of the American Thyroid Association 23 (12), pp.1600-1608. (10.1089/thy.2013.0194)
- Taylor, P. et al. 2013. A review of the clinical consequences of variation in thyroid function within the reference range. Journal of Clinical Endocrinology & Metabolism 98 (9), pp.3562-3571. (10.1210/jc.2013-1315)
Articles
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- Korevaar, T. I. et al., 2016. An invitation to join the consortium on thyroid and pregnancy [Letter]. European Thyroid Journal 5 (4), pp.277. (10.1159/000452331)
- Korevaar, T. I. M. et al., 2016. An invitation to join the consortium on thyroid and pregnancy [Letter]. Obstetrics and Gynaecology 128 (4), pp.913. (10.1097/AOG.0000000000001670)
- Eligar, V. et al. 2016. Thyroxine replacement: a clinical endocrinologists viewpoint. Annals of Clinical Biochemistry 53 (4), pp.421-433. (10.1177/0004563216642255)
- Taylor, P. N. and Vaidya, B. 2016. Iodine supplementation in pregnancy - is it time?. Clinical Endocrinology 85 (1), pp.10-14. (10.1111/cen.13065)
- Tabasum, A. et al., 2016. Thyroid antibody-negative euthyroid Graves' ophthalmopathy. Endocrinology, Diabetes & Metabolism Case Reports 2016 (1) EDM160008. (10.1530/EDM-16-0008)
- Witczak, J. et al. 2016. Predicting malignancy in thyroid nodules: feasibility of a predictive model integrating clinical, biochemical, and ultrasound characteristics. Thyroid Research 9 (1) 4. (10.1186/s13044-016-0033-y)
- Taylor, P. et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101 (2), pp.730-738. (10.1210/jc.2015-3505)
- Lazarus, J. and Taylor, P. 2016. Hypothyroxinaemia and brain development. Acta Endocrinologica 12 (1), pp.1-6. (10.4183/aeb.2016.1)
- Taylor, P. et al. 2015. Weekly intramuscular injection of Levothyroxine following Myxoedema: a practical solution to an old crisis. Case Reports in Endocrinology 2015 169194. (10.1155/2015/169194)
- Stacey, M. J. et al., 2015. Susceptibility to exertional heat illness and hospitalisation risk in UK military personnel. BMJ Open Sport & Exercise Medicine 1 (1), pp.e000055. (10.1136/bmjsem-2015-000055)
- Taylor, P. N. et al. 2015. Should all women be screened for thyroid dysfunction in pregnancy?. Women's Health 11 (3), pp.295-307. (10.2217/whe.15.7)
- Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6 5681. (10.1038/ncomms6681)
- Taylor, P. N. et al. 2014. Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the controlled antenatal thyroid study. Journal of Clinical Endocrinology and Metabolism 99 (11), pp.4291-4298. (10.1210/jc.2014-1901)
- Taylor, P. et al. 2014. TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study. Journal of Clinical Endocrinology & Metabolism 99 (10), pp.3895-3902. (10.1210/jc.2014-1954)
- Taylor, P. et al. 2014. Therapy of endocrine disease: impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. European Journal of Endocrinology 170 (1), pp.R1-R15. (10.1530/EJE-13-0651)
- Taylor, P. N. et al. 2014. Falling threshold for treatment of borderline elevated thyrotropin levels - balancing benefits and risks: evidence from a large community-based study. JAMA Internal Medicine 174 (1), pp.32-39. (10.1001/jamainternmed.2013.11312)
- Hales, C. et al. 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14 (1) 95. (10.1186/1472-6823-14-95)
- Draman, M. et al. 2013. Effects of Prostaglandin F2a on adipocyte biology relevant to graves' orbitopathy. Thyroid: official journal of the American Thyroid Association 23 (12), pp.1600-1608. (10.1089/thy.2013.0194)
- Taylor, P. et al. 2013. A review of the clinical consequences of variation in thyroid function within the reference range. Journal of Clinical Endocrinology & Metabolism 98 (9), pp.3562-3571. (10.1210/jc.2013-1315)
Conferences
- Shafti, M. et al., 2022. The role of secondary psychopathy and emotional dysregulation in forensic mental health service users? Dual-harm. Presented at: Royal College of Psychiatrists Faculty of Forensic Psychiatry Conference Online 02-04 March 2022.
Other
- Allen, L. et al. 2024. A study of relative maternal protection against type 1 diabetes in offspring: Statistical analysis plan. Elsevier
Thesis
- Taylor, P. 2018. Common variation in thyroid hormone status; effects on key health outcomes. PhD Thesis , Cardiff University.
Bywgraffiad
Rwy'n Ddarllenydd Clinigol ac yn Feddyg Ymgynghorol sy'n arbenigo mewn epidemioleg a diabetes ac endocrinoleg ym Mhrifysgol Caerdydd ac Ysbyty Athrofaol Cymru. Cefais fy raddau meddygol israddedig o Brifysgol St. Andrews a Phrifysgol Manceinion ac ymgymerais â fy hyfforddiant meddygol craidd yn Ne Manceinion ac yna yn y ddau ysbyty addysgu yng Nghaeredin (Western General Hospital a Edinburgh Royal Infirmary). Dechreuais hyfforddiant arbenigol mewn diabetes ac endocrinoleg ym Mryste a Chaerfaddon cyn derbyn ysgoloriaeth MRC fawreddog i ymgymryd â gradd meistr mewn epidemioleg yn Ysgol Hylendid a Meddygaeth Drofannol Llundain.
Yna ymunais â chynllun Hyfforddiant Academaidd Clinigol Cymru (WCAT). Yma cwblheais fy PhD mewn epidemioleg thyroid o dan yr Athro Colin Dayan (Caerdydd) a'r Athro Nicholas Timpson (Bryste). Canolbwyntiodd fy PhD ar effeithiau amrywiad cyffredin mewn statws thyroid yn ogystal â rhagnodi hormonau thyroid a sgrinio thyroid mewn beichiogrwydd. Yn fy PhD fe wnes i hefyd ymgymryd â'r dadansoddiad cyntaf yn seiliedig ar ddilyniant genom cyfan o swyddogaeth thyroid mewn carfanau a'r astudiaeth Mendelian Randomization gyntaf mewn thyroidology. Yn dilyn fy PhD rwyf wedi bod yn rhan helaeth o'r treialon CATS (sgrinio thyroid mewn beichiogrwydd) a CIRTED (clefyd llygaid thyroid). Yn ogystal â pharhau â'm hymchwil mewn clefyd thyroid, rwyf wedi ymestyn fy ngwaith i imiwnoleg diabetes math 1 a monitro glwcos parhaus. Rwy'n gobeithio defnyddio fy sgiliau ymchwil a'm harbenigedd mewn treialon clinigol i ddatblygu treialon platfform i nodi cyfundrefnau triniaeth sy'n cadw swyddogaeth beta-gelloedd mewn unigolion sydd â diabetes math 1 ac sydd mewn perygl o ddiabetes. Rwyf hefyd yn defnyddio monitro glwcos parhaus i nodi marcwyr newydd o swyddogaeth celloedd beta.
Rwyf wedi derbyn gwobrau mewn cynadleddau cenedlaethol a rhyngwladol am fy ngwaith ac mae gen i dros 70 o gyhoeddiadau sy'n ymwneud â thyroid a diabetes gan gynnwys cyhoeddiadau yn y Lancet, Nature Medicine, JAMA, Lancet Diabetes and Endocrinology, JAMA Internal Medicine, Nature Reviews Endocrinology a Nature Communications.
Anrhydeddau a dyfarniadau
2022 Ymddiriedolaeth Endocrinoleg Glinigol enillydd y gynhadledd Cymdeithas Endocrinoleg Haniaethol Glinigol orau
2020 Seren gynyddol mewn endocrinoleg, Cymdeithas endocrinoleg
Cymdeithas Meddygon Prydain Fawr ac Iwerddon 2018 - cyflwyniad llafar gorau
Cymdeithas Thyroid Prydain 2016 - haniaethol gorau
2014 Ymddiriedolaeth endocrinoleg Glinigol enillydd y gynhadledd Cymdeithas Endocrinoleg Haniaethol Glinigol Gorau
Cymdeithas Thyroid Prydain 2014 - cyflwyniad llafar gorau
Cymdeithas Thyroid Prydain 2010 - cyflwyniad llafar gorau
Gwobr ymchwilydd newydd 2010 ECTS
Gwobr eithriadol IPSEN 2009
News articles
Contact Details
[email protected]
Prif Adeilad yr Ysbyty, Llawr Cyswllt C2, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Prif Adeilad yr Ysbyty, Llawr Cyswllt C2, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Diabetes
- Thyroid
- Epidemioleg
