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Yr Athro Kathy Triantafilou
(hi/ei)
Cadeirydd Imiwnoleg Pediatrig a Haint a Chyfarwyddwr yr Is-adran Heintiau ac Imiwnedd
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Fi yw Pennaeth Adran Heintiau ac Imiwnedd Prifysgol Caerdydd, Ysgol Meddygaeth. Rwyf hefyd yn Gadeirydd Imiwnoleg Pediatrig a Haint sy'n arwain y thema Llid yn yr Is-adran. Mae fy ymchwil yn canolbwyntio ar ddatrys y mecanweithiau moleciwlaidd y tu ôl i gydnabyddiaeth gynhenid bacteria yn ogystal â pathogenau firaol. Fy ffocws penodol yw ar dderbynyddion adnabod patrymau (PRRs) a synhwyro imiwnedd cynhenid y derbynyddion tebyg i doll (TLRs), y derbynyddion tebyg i NOD (NLRs, inflammasomes) a'r llwybr cGAS-STING yn ogystal â'u croessgwrs â llwybrau imiwnedd eraill fel y system ategu a sut y gallwn eu targedu'n therapiwtig ar gyfer gwahanol gyflyrau llidiol.
Cyhoeddiad
2024
- Lobanova, E. et al. 2024. ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases. Nature Communications 15, article number: 9690. (10.1038/s41467-024-53547-0)
- Triantafilou, K., Szomolay, B., Shepherd, M. W., Ramanjulu, J. and Triantafilou, M. 2024. STING orchestrates EV-D68 replication and immunometabolism within viral-induced replication organelles. Viruses 16(10), article number: 1541. (10.3390/v16101541)
2022
- Jimenez-Duran, G. et al. 2022. Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages. Frontiers in Immunology 13, article number: 918551. (10.3389/fimmu.2022.918551)
- Triantafilou, M. et al. 2022. Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication. Nature Communications 13(1), article number: 1406. (10.1038/s41467-022-28745-3)
2021
- Triantafilou, K. 2021. Enigmatic inflammasomes - sequel (Part 2). Immunology 163(4), pp. 345-347. (10.1111/imm.13387)
- Triantafilou, K. et al. 2021. Differential recognition of HIV-stimulated IL-1? and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages. PLoS Pathogens 17(4), article number: e1009417. (10.1371/journal.ppat.1009417)
- Triantafilou, K. 2021. Enigmatic inflammasomes. Immunology 162(3), pp. 249-251. (10.1111/imm.13309)
2019
- Shimauchi, T. et al. 2019. Dendritic cells promote the spread of human T-cell leukemia virus type 1 via bidirectional interactions with CD4+ T cells. Journal of Investigative Dermatology 139(1), pp. 157-166. (10.1016/j.jid.2018.06.188)
2018
- Carroll, R. G. et al. 2018. An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry 293(15), pp. 5509-5521. (10.1074/jbc.RA118.001921)
2017
- Patel, M. N. et al. 2017. Inflammasome priming in sterile inflammatory disease. Trends in Molecular Medicine 23(2), pp. 165-180. (10.1016/j.molmed.2016.12.007)
2016
- Triantafilou, M., Hughes, T., Morgan, B. and Triantafilou, K. 2016. Complementing the inflammasome. Immunology 147(2), pp. 152-164. (10.1111/imm.12556)
2014
- Triantafilou, K. and Triantafilou, M. 2014. Ion flux in the lung: virus-induced inflammasome activation. Trends in Microbiology 22(10), pp. 580-588. (10.1016/j.tim.2014.06.002)
- Maekawa, T. et al. 2014. Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis. Cell Host and Microbe 15(6), pp. 768-778. (10.1016/j.chom.2014.05.012)
- Shang, L. et al. 2014. Selective antibody intervention of toll-like receptor 4 activation through Fc γ receptor tethering. Journal of Biological Chemistry 289(22), pp. 15309-15318. (10.1074/jbc.M113.537936)
- Triantafilou, K., Eryilmazlar, D. and Triantafilou, M. 2014. Herpes simplex virus 2-induced activation in vaginal cells involves Toll-like receptors 2 and 9 and DNA sensors DAI and IFI16. American Journal of Obstetrics and Gynecology 210(2), pp. 122.e1-122.e10. (10.1016/j.ajog.2013.09.034)
2013
- Triantafilou, K., Kar, S., van Kuppeveld, F. J. M. and Triantafilou, M. 2013. Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells. American Journal of Respiratory Cell and Molecular Biology 49(6), pp. 923. (10.1165/rcmb.2013-0032OC)
- Triantafilou, K., Hughes, T. R., Triantafilou, M. and Morgan, B. P. 2013. The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of Cell Science 126(13), pp. 2903-2913. (10.1242/jcs.124388)
- Triantafilou, M., De Glanville, B., Aboklaish, A. F., Spiller, O. B., Kotecha, S. and Triantafilou, K. 2013. Synergic activation of Toll-Like Receptor (TLR) 2/6 and 9 in response to ureaplasma parvum & urealyticum in human amniotic epithelial cells. PLoS ONE 8(4), article number: e61199. (10.1371/journal.pone.0061199)
- Triantafilou, K., Kar, S., Vakakis, E., Kotecha, S. and Triantafilou, M. 2013. Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation. Thorax 68(1), pp. 66-75. (10.1136/thoraxjnl-2012-202182)
2012
- Triantafilou, K., Vakakis, E., Kar, S., Richer, E., Evans, G. L. and Triantafilou, M. 2012. Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses. Journal of Cell Science 125(20), pp. 4761-4769. (10.1242/jcs.103887)
- Mancek-Keber, M. et al. 2012. MARCKS as a Negative Regulator of Lipopolysaccharide Signaling. The Journal of Immunology 188(8), pp. 3893-3902. (10.4049/jimmunol.1003605)
- Triantafilou, M. et al. 2012. Serum proteins modulate lipopolysaccharide and lipoteichoic acid-induced activation and contribute to the clinical outcome of sepsis. Virulence 3(2), pp. 136-145. (10.4161/viru.19077)
- Triantafilou, K. and Triantafilou, M. 2012. Visualising PAMP-PRR interactions using nanoscale imaging. In: Christodoulides, M. ed. Neisseria meningitidis: Advanced Methods and Protocols. Methods in Molecular Biology Vol. 799. New York: Humana Press, pp. 253-266., (10.1007/978-1-61779-346-2_16)
2011
- Triantafilou, K., Vakakis, E., Richer, E. A. J., Evans, G. L., Villiers, J. P. and Triantafilou, M. 2011. Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response. Virulence 2(1), pp. 22-29. (10.4161/viru.2.1.13807)
2010
- Wang, M. et al. 2010. Microbial hijacking of complement-toll-like receptor crosstalk. Science Signaling 3(109), article number: ra11. (10.1126/scisignal.2000697)
- Bunk, S. et al. 2010. Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood. The Journal of Immunology 185(6), pp. 3708-3717. (10.4049/jimmunol.0901660)
2009
- Pierce, D. L. et al. 2009. Host adhesive activities and virulence of novel fimbrial proteins of porphyromonas gingivalis. Infection and Immunity 77(8), pp. 3294-3301. (10.1128/IAI.00262-09)
2008
- Hajishengallis, G., Wang, M., Liang, S., Triantafilou, M. and Triantafilou, K. 2008. Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proceedings of the National Academy of Sciences of the United States of America 105(36), pp. 13532-13537. (10.1073/pnas.0803852105)
- Triantafilou, M., Lepper, P. M., Briault, C. D., Ahmed, M. A. E., Dmochowski, J. M., Schumann, C. and Triantafilou, K. 2008. Chemokine receptor 4 (CXCR4) is part of the lipopolysaccharide "sensing apparatus". European Journal of Immunology 38(1), pp. 192-203. (10.1002/eji.200636821)
- Parker, L. C. et al. 2008. A phosphatidylserine species inhibits a range of TLR- but not IL-1β-induced inflammatory responses by disruption of membrane microdomains. The Journal of Immunology 181(8), pp. 5606-5617.
Articles
- Lobanova, E. et al. 2024. ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases. Nature Communications 15, article number: 9690. (10.1038/s41467-024-53547-0)
- Triantafilou, K., Szomolay, B., Shepherd, M. W., Ramanjulu, J. and Triantafilou, M. 2024. STING orchestrates EV-D68 replication and immunometabolism within viral-induced replication organelles. Viruses 16(10), article number: 1541. (10.3390/v16101541)
- Jimenez-Duran, G. et al. 2022. Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages. Frontiers in Immunology 13, article number: 918551. (10.3389/fimmu.2022.918551)
- Triantafilou, M. et al. 2022. Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication. Nature Communications 13(1), article number: 1406. (10.1038/s41467-022-28745-3)
- Triantafilou, K. 2021. Enigmatic inflammasomes - sequel (Part 2). Immunology 163(4), pp. 345-347. (10.1111/imm.13387)
- Triantafilou, K. et al. 2021. Differential recognition of HIV-stimulated IL-1? and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages. PLoS Pathogens 17(4), article number: e1009417. (10.1371/journal.ppat.1009417)
- Triantafilou, K. 2021. Enigmatic inflammasomes. Immunology 162(3), pp. 249-251. (10.1111/imm.13309)
- Shimauchi, T. et al. 2019. Dendritic cells promote the spread of human T-cell leukemia virus type 1 via bidirectional interactions with CD4+ T cells. Journal of Investigative Dermatology 139(1), pp. 157-166. (10.1016/j.jid.2018.06.188)
- Carroll, R. G. et al. 2018. An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry 293(15), pp. 5509-5521. (10.1074/jbc.RA118.001921)
- Patel, M. N. et al. 2017. Inflammasome priming in sterile inflammatory disease. Trends in Molecular Medicine 23(2), pp. 165-180. (10.1016/j.molmed.2016.12.007)
- Triantafilou, M., Hughes, T., Morgan, B. and Triantafilou, K. 2016. Complementing the inflammasome. Immunology 147(2), pp. 152-164. (10.1111/imm.12556)
- Triantafilou, K. and Triantafilou, M. 2014. Ion flux in the lung: virus-induced inflammasome activation. Trends in Microbiology 22(10), pp. 580-588. (10.1016/j.tim.2014.06.002)
- Maekawa, T. et al. 2014. Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis. Cell Host and Microbe 15(6), pp. 768-778. (10.1016/j.chom.2014.05.012)
- Shang, L. et al. 2014. Selective antibody intervention of toll-like receptor 4 activation through Fc γ receptor tethering. Journal of Biological Chemistry 289(22), pp. 15309-15318. (10.1074/jbc.M113.537936)
- Triantafilou, K., Eryilmazlar, D. and Triantafilou, M. 2014. Herpes simplex virus 2-induced activation in vaginal cells involves Toll-like receptors 2 and 9 and DNA sensors DAI and IFI16. American Journal of Obstetrics and Gynecology 210(2), pp. 122.e1-122.e10. (10.1016/j.ajog.2013.09.034)
- Triantafilou, K., Kar, S., van Kuppeveld, F. J. M. and Triantafilou, M. 2013. Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells. American Journal of Respiratory Cell and Molecular Biology 49(6), pp. 923. (10.1165/rcmb.2013-0032OC)
- Triantafilou, K., Hughes, T. R., Triantafilou, M. and Morgan, B. P. 2013. The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of Cell Science 126(13), pp. 2903-2913. (10.1242/jcs.124388)
- Triantafilou, M., De Glanville, B., Aboklaish, A. F., Spiller, O. B., Kotecha, S. and Triantafilou, K. 2013. Synergic activation of Toll-Like Receptor (TLR) 2/6 and 9 in response to ureaplasma parvum & urealyticum in human amniotic epithelial cells. PLoS ONE 8(4), article number: e61199. (10.1371/journal.pone.0061199)
- Triantafilou, K., Kar, S., Vakakis, E., Kotecha, S. and Triantafilou, M. 2013. Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation. Thorax 68(1), pp. 66-75. (10.1136/thoraxjnl-2012-202182)
- Triantafilou, K., Vakakis, E., Kar, S., Richer, E., Evans, G. L. and Triantafilou, M. 2012. Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses. Journal of Cell Science 125(20), pp. 4761-4769. (10.1242/jcs.103887)
- Mancek-Keber, M. et al. 2012. MARCKS as a Negative Regulator of Lipopolysaccharide Signaling. The Journal of Immunology 188(8), pp. 3893-3902. (10.4049/jimmunol.1003605)
- Triantafilou, M. et al. 2012. Serum proteins modulate lipopolysaccharide and lipoteichoic acid-induced activation and contribute to the clinical outcome of sepsis. Virulence 3(2), pp. 136-145. (10.4161/viru.19077)
- Triantafilou, K., Vakakis, E., Richer, E. A. J., Evans, G. L., Villiers, J. P. and Triantafilou, M. 2011. Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response. Virulence 2(1), pp. 22-29. (10.4161/viru.2.1.13807)
- Wang, M. et al. 2010. Microbial hijacking of complement-toll-like receptor crosstalk. Science Signaling 3(109), article number: ra11. (10.1126/scisignal.2000697)
- Bunk, S. et al. 2010. Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood. The Journal of Immunology 185(6), pp. 3708-3717. (10.4049/jimmunol.0901660)
- Pierce, D. L. et al. 2009. Host adhesive activities and virulence of novel fimbrial proteins of porphyromonas gingivalis. Infection and Immunity 77(8), pp. 3294-3301. (10.1128/IAI.00262-09)
- Hajishengallis, G., Wang, M., Liang, S., Triantafilou, M. and Triantafilou, K. 2008. Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proceedings of the National Academy of Sciences of the United States of America 105(36), pp. 13532-13537. (10.1073/pnas.0803852105)
- Triantafilou, M., Lepper, P. M., Briault, C. D., Ahmed, M. A. E., Dmochowski, J. M., Schumann, C. and Triantafilou, K. 2008. Chemokine receptor 4 (CXCR4) is part of the lipopolysaccharide "sensing apparatus". European Journal of Immunology 38(1), pp. 192-203. (10.1002/eji.200636821)
- Parker, L. C. et al. 2008. A phosphatidylserine species inhibits a range of TLR- but not IL-1β-induced inflammatory responses by disruption of membrane microdomains. The Journal of Immunology 181(8), pp. 5606-5617.
Book sections
- Triantafilou, K. and Triantafilou, M. 2012. Visualising PAMP-PRR interactions using nanoscale imaging. In: Christodoulides, M. ed. Neisseria meningitidis: Advanced Methods and Protocols. Methods in Molecular Biology Vol. 799. New York: Humana Press, pp. 253-266., (10.1007/978-1-61779-346-2_16)
Ymchwil
Dros yr ychydig flynyddoedd diwethaf, mae'r grŵp Triantafilou wedi bod yn canolbwyntio ar ddatrys y mecanweithiau moleciwlaidd y tu ôl i gydnabyddiaeth gynhenid bacteria yn ogystal â pathogenau firaol. Yn benodol, rydym wedi canolbwyntio ar gynnwys derbynyddion adnabod patrymau (PRRs) fel y derbynyddion tebyg i doll (TLRs), y derbynyddion tebyg i NOD (NLRs, inflammasomes) yn ogystal â'r llwybr cGAS-STING a'u synhwyro imiwnedd cynhenid yn ogystal â'u croessiarad â llwybrau imiwnedd eraill fel y system Complement. Am y pum mlynedd diwethaf, rwyf wedi bod ar secondiad yn GlaxoSmithKline (GSK) fel rhan o gydweithrediad unigryw-academia diwydiant o'r enw Rhaglen Sabothol Catalydd Imiwnoleg Elion a Du er mwyn perfformio ymchwil feddygol. Mae ein gwaith diweddaraf yn y diwydiant fferyllol wedi bod yn canolbwyntio ar ddatrys mecanweithiau imiwnedd cynhenid ar gyfer gwerth clinigol uniongyrchol - gan drosi darganfyddiadau i feddyginiaethau posibl. Mae ein profiad yn GSK, wedi rhoi cipolwg gwych i ni ar sut mae'r rhaglenni darganfod cyffuriau yn gweithio. Yn ystod y cyfnod hwnnw, rydym wedi bod yn arwain prosiectau a oedd yn canolbwyntio ar synhwyro imiwnedd cynhenid firysau, rhyngweithiadau ymfflamychol ategu yn ogystal ag ymchwilio i sut mae imiwnometabolaeth yn modiwleiddio'r ymateb imiwnedd cynhenid, gyda blaenoriaeth i drosi'r canfyddiadau yn feddyginiaethau.
Addysgu
Modiwl 1 (MET920) o'r MSc Imiwnoleg Gymhwysol ac Arbrofol
Modiwl 5 (MET920) o'r MSc Imiwnoleg Gymhwysol ac Arbrofol
Dysgu ar sail achos (CBL) Tiwtor Blwyddyn 1
SSC Blwyddyn 1 - Adolygiad Llenyddiaeth
SSC Blwyddyn 2 - Goruchwyliwr lleoliad labordy
Mentora Academaidd
Bywgraffiad
Aelodaethau proffesiynol
Cymdeithas Imiwnoleg Prydain
Safleoedd academaidd blaenorol
Ebrill 2024 - Cyfarwyddwr Is-adran Heintiau ac Imiwnedd, Prifysgol Caerdydd, Ysgol Meddygaeth
Hydref 2010 - Cadeirydd Imiwnoleg a Heintiau Pediatrig, Prifysgol Caerdydd, Ysgol Meddygaeth
Mawrth 2016 - Ionawr 2021 Rhaglen Sabothol Catalydd Imiwnoleg Ellion a Du, GlaxoSmithKline (GSK)
Hydref 2003 - Medi 2010 Darllenydd mewn Imiwnoleg, Prifysgol Sussex
Hydref 2002 - Medi 2003 Uwch Ddarlithydd mewn Imiwnoleg, Prifysgol Portsmouth
Mawrth 2001 - Medi 2002 Darlithydd mewn Imiwnoleg, Prifysgol Portsmouth