![Victoria Tyrrell](https://profiles-cardiff.imgix.net/attachments/7623?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Cyhoeddiad
2026
- Naicker, B. et al. 2026. Comparing the quantitation of specialized pro-resolving mediators in plasma and serum using ELISA and LC-MS/MS. Prostaglandins, Leukotrienes and Essential Fatty Acids 209 102731. (10.1016/j.plefa.2026.102731)
- Xu, H. et al., 2026. iPLA2β: A novel store-operated calcium entry modulator contributing to muscle dysfunction during denervation. Science Advances 12 (29) eaed1646. (10.1126/sciadv.aed1646)
- Czyżowska‐Froemling, A. et al., 2026. Loss of calcium‐dependent phospholipase A2 contributes to multi‐omic changes in mouse denervated skeletal muscle. Physiological Reports 14 (10) e70906. (10.14814/phy2.70906)
- Tyrrell, V. J. et al. 2026. The coronavirus envelope is modulated by host inflammation and enriched in bioactive lipids required for replication. (10.1101/2025.11.03.686211)
2025
- Marques, E. et al., 2025. An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice. Nature Communications 16 10222. (10.1038/s41467-025-65023-4)
- Morgan, B. et al. 2025. Pro-Coagulant Lipids in Physiological Ratios Found in the Activated Platelet Membrane Do Not Impact Clot Structure or Fibrinolysis in Purified Assays. Journal of Blood Medicine 16 , pp.509-521. (10.2147/jbm.s527558)
- Thomas, C. P. et al. 2025. 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation. Proceedings of the National Academy of Sciences 122 (36) e2502640122. (10.1073/pnas.2502640122)
- Costa, D. O. et al. 2025. Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis.. Journal of Lipid Research 66 (7) 100842. (10.1016/j.jlr.2025.100842)
- Smith, K. A. et al. 2025. Helminth-induced prostaglandin signalling and dietary shifts in PUFA metabolism promote colitis-associated cancer. Journal of Lipid Research 66 (7) 100837. (10.1016/j.jlr.2025.100837)
- Goepp, M. et al., 2025. Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis. Cell Host & Microbe 33 (5), pp.671-687. (10.1016/j.chom.2025.04.014)
- Protty, M. B. et al. 2025. Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.. Journal of Lipid Research 66 (1) 100727. (10.1016/j.jlr.2024.100727)
- Ghorasaini, M. et al., 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology. Vol. 2855, New York, NY, USA: Springer. , pp.155-169. (10.1007/978-1-0716-4116-3_10)
2024
- Torta, F. et al., 2024. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nature Communications 15 (1) 8562. (10.1038/s41467-024-52087-x)
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44 (9), pp.2038-2052. (10.1161/ATVBAHA.124.320902)
2023
- Millrine, D. et al., 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211 (2), pp.274-286. (10.4049/jimmunol.2300114)
2022
- Brown, J. et al., 2022. The role of oxylipins in muscle atrophy. Free Radical Biology and Medicine 192 (S1), pp.16-17. (10.1016/j.freeradbiomed.2022.10.009)
- Brown, J. L. et al., 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57 102518. (10.1016/j.redox.2022.102518)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63 (6) 100208. (10.1016/j.jlr.2022.100208)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13 (1) 139. (10.1038/s41467-021-27766-8)
2021
- Diskin, C. et al., 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207 (10), pp.2551-2560. (10.4049/jimmunol.2100402)
- Diskin, C. et al., 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207 (10), pp.2561-2569. (10.4049/jimmunol.2100488)
- Contursi, A. et al., 2021. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. Journal of Lipid Research 62 100109. (10.1016/j.jlr.2021.100109)
- Crittenden, S. et al., 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7 (7) eabd7954. (10.1126/sciadv.abd7954)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62 100094. (10.1016/j.jlr.2021.100094)
2020
- Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15 (10) e0240189. (10.1371/journal.pone.0240189)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39 (14) e103454. (10.15252/embj.2019103454)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13 (3), pp.149-164. e002806. (10.1161/CIRCGEN.119.002806)
2019
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865 (9), pp.2538-2550. (10.1016/j.bbadis.2019.06.011)
- Kornilov, A. et al., 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294 , pp.9225-9238. (10.1074/jbc.RA119.008915)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16), pp.8038-8047. (10.1073/pnas.1814409116)
2018
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3 (6) e98459. (10.1172/jci.insight.98459)
2017
- Zhao, J. et al., 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57 (6)(10.1165/rcmb.2017-0031OC)
- Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10 (507) eaan2787. (10.1126/scisignal.aan2787)
- Uderhardt, S. et al., 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214 (7), pp.2121-2138. (10.1084/jem.20161070)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11 , pp.663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2 (1)(10.12688/wellcomeopenres.10308.1)
2016
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9), pp.2222-2232. (10.1002/eji.201646528)
2015
- Etling, E. B. et al., 2015. Lipoxygenase metabolite profile in human airway epithelial cells (HAECs) [Abstract]. American Journal of Respiratory and Critical Care Medicine 191 (S1) A1279. (10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a1279)
- Morgan, A. H. et al., 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4 , pp.40-47. (10.1016/j.redox.2014.11.005)
2014
- Mathie, S. A. et al., 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70 (1), pp.80-89. (10.1111/all.12536)
- Thomas, C. P. et al. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9 (1), pp.51-63. (10.1038/nprot.2013.163)
2013
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54 (11), pp.3085-3097. (10.1194/jlr.M041533)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110 (15), pp.5875-5880. (10.1073/pnas.1222419110)
2012
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287 (50), pp.41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818 (10), pp.2403-2412. (10.1016/j.bbamem.2011.12.013)
2011
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6), pp.2033-2043. (10.1182/blood-2010-04-278887)
2010
- Jones, G. W. et al. 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184 (4), pp.2130-2139. (10.4049/jimmunol.0901528)
- Jones, G. W. et al. 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184 (4), pp.2130-2139.
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5 (12), pp.1919-1931. (10.1038/nprot.2010.162)
2008
- Hams, E. et al., 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181 (3), pp.2174-2180.
2007
- Hams, E. et al., 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39 (1), pp.14-14. (10.1016/j.cyto.2007.07.053)
Adrannau llyfrau
- Ghorasaini, M. et al., 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology. Vol. 2855, New York, NY, USA: Springer. , pp.155-169. (10.1007/978-1-0716-4116-3_10)
Erthyglau
- Naicker, B. et al. 2026. Comparing the quantitation of specialized pro-resolving mediators in plasma and serum using ELISA and LC-MS/MS. Prostaglandins, Leukotrienes and Essential Fatty Acids 209 102731. (10.1016/j.plefa.2026.102731)
- Xu, H. et al., 2026. iPLA2β: A novel store-operated calcium entry modulator contributing to muscle dysfunction during denervation. Science Advances 12 (29) eaed1646. (10.1126/sciadv.aed1646)
- Czyżowska‐Froemling, A. et al., 2026. Loss of calcium‐dependent phospholipase A2 contributes to multi‐omic changes in mouse denervated skeletal muscle. Physiological Reports 14 (10) e70906. (10.14814/phy2.70906)
- Tyrrell, V. J. et al. 2026. The coronavirus envelope is modulated by host inflammation and enriched in bioactive lipids required for replication. (10.1101/2025.11.03.686211)
- Marques, E. et al., 2025. An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice. Nature Communications 16 10222. (10.1038/s41467-025-65023-4)
- Morgan, B. et al. 2025. Pro-Coagulant Lipids in Physiological Ratios Found in the Activated Platelet Membrane Do Not Impact Clot Structure or Fibrinolysis in Purified Assays. Journal of Blood Medicine 16 , pp.509-521. (10.2147/jbm.s527558)
- Thomas, C. P. et al. 2025. 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation. Proceedings of the National Academy of Sciences 122 (36) e2502640122. (10.1073/pnas.2502640122)
- Costa, D. O. et al. 2025. Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis.. Journal of Lipid Research 66 (7) 100842. (10.1016/j.jlr.2025.100842)
- Smith, K. A. et al. 2025. Helminth-induced prostaglandin signalling and dietary shifts in PUFA metabolism promote colitis-associated cancer. Journal of Lipid Research 66 (7) 100837. (10.1016/j.jlr.2025.100837)
- Goepp, M. et al., 2025. Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis. Cell Host & Microbe 33 (5), pp.671-687. (10.1016/j.chom.2025.04.014)
- Protty, M. B. et al. 2025. Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.. Journal of Lipid Research 66 (1) 100727. (10.1016/j.jlr.2024.100727)
- Torta, F. et al., 2024. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nature Communications 15 (1) 8562. (10.1038/s41467-024-52087-x)
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44 (9), pp.2038-2052. (10.1161/ATVBAHA.124.320902)
- Millrine, D. et al., 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211 (2), pp.274-286. (10.4049/jimmunol.2300114)
- Brown, J. et al., 2022. The role of oxylipins in muscle atrophy. Free Radical Biology and Medicine 192 (S1), pp.16-17. (10.1016/j.freeradbiomed.2022.10.009)
- Brown, J. L. et al., 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57 102518. (10.1016/j.redox.2022.102518)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63 (6) 100208. (10.1016/j.jlr.2022.100208)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13 (1) 139. (10.1038/s41467-021-27766-8)
- Diskin, C. et al., 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207 (10), pp.2551-2560. (10.4049/jimmunol.2100402)
- Diskin, C. et al., 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207 (10), pp.2561-2569. (10.4049/jimmunol.2100488)
- Contursi, A. et al., 2021. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. Journal of Lipid Research 62 100109. (10.1016/j.jlr.2021.100109)
- Crittenden, S. et al., 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7 (7) eabd7954. (10.1126/sciadv.abd7954)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62 100094. (10.1016/j.jlr.2021.100094)
- Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15 (10) e0240189. (10.1371/journal.pone.0240189)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39 (14) e103454. (10.15252/embj.2019103454)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13 (3), pp.149-164. e002806. (10.1161/CIRCGEN.119.002806)
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865 (9), pp.2538-2550. (10.1016/j.bbadis.2019.06.011)
- Kornilov, A. et al., 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294 , pp.9225-9238. (10.1074/jbc.RA119.008915)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16), pp.8038-8047. (10.1073/pnas.1814409116)
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3 (6) e98459. (10.1172/jci.insight.98459)
- Zhao, J. et al., 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57 (6)(10.1165/rcmb.2017-0031OC)
- Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10 (507) eaan2787. (10.1126/scisignal.aan2787)
- Uderhardt, S. et al., 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214 (7), pp.2121-2138. (10.1084/jem.20161070)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11 , pp.663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2 (1)(10.12688/wellcomeopenres.10308.1)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9), pp.2222-2232. (10.1002/eji.201646528)
- Etling, E. B. et al., 2015. Lipoxygenase metabolite profile in human airway epithelial cells (HAECs) [Abstract]. American Journal of Respiratory and Critical Care Medicine 191 (S1) A1279. (10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a1279)
- Morgan, A. H. et al., 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4 , pp.40-47. (10.1016/j.redox.2014.11.005)
- Mathie, S. A. et al., 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70 (1), pp.80-89. (10.1111/all.12536)
- Thomas, C. P. et al. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9 (1), pp.51-63. (10.1038/nprot.2013.163)
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54 (11), pp.3085-3097. (10.1194/jlr.M041533)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110 (15), pp.5875-5880. (10.1073/pnas.1222419110)
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287 (50), pp.41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818 (10), pp.2403-2412. (10.1016/j.bbamem.2011.12.013)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6), pp.2033-2043. (10.1182/blood-2010-04-278887)
- Jones, G. W. et al. 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184 (4), pp.2130-2139. (10.4049/jimmunol.0901528)
- Jones, G. W. et al. 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184 (4), pp.2130-2139.
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5 (12), pp.1919-1931. (10.1038/nprot.2010.162)
- Hams, E. et al., 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181 (3), pp.2174-2180.
- Hams, E. et al., 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39 (1), pp.14-14. (10.1016/j.cyto.2007.07.053)
Ymchwil
Mae ein hymchwil yn canolbwyntio ar ddeall rôl lipidau a'u metabolion mewn llid, arthritis, clefyd cardiofasgwlaidd a thrombosis. Rydym yn cynnal cyfleuster sbectrometreg màs a sefydlwyd dros 20 mlynedd yn ôl.
Rydym yn gartref i ddau sbectromedr màs Sciex Triple Quad / QTRAP o'r radd flaenaf wedi'u cysylltu â systemau Shimadzu LC ar gyfer profion lipidomig wedi'u seilio ar MRM wedi'u targedu.
Rydym yn cydweithio ag ymchwilwyr clinigol ac anhlinigol yn lleol, yn y DU a ledled y byd a gallwn ddarparu lipidomeg a mesur a meintioli moleciwlau bach trwy ein cyfleuster sbectrometreg Màs pwrpasol
Cyfleuster craidd
Mae ein cyfleuster yn darparu dadansoddiad meintiol uwch o lipidau a moleciwlau bach gan ddefnyddio sbectrometreg màs quadrupole triphlyg o'r radd flaenaf. Rydym yn cefnogi ystod eang o gymwysiadau ymchwil biolegol a chlinigol, gan gynnwys astudiaethau o glefydau llidiol a cardiofasgwlaidd, canser, arthritis, anhwylderau niwroddirywiol, yn ogystal â threialon clinigol a rhaglenni darganfod cyffuriau.
Mae ein platfformau yn amlbwrpas iawn a gellir eu cymhwyso hefyd i brosiectau mewn gwyddor bwyd, maeth, gwyddor planhigion, ac ymchwil microbiome.
Ar gyfer dadansoddiad metabolit wedi'i dargedu, rydym yn cynnig datblygiad assay pwrpasol wedi'i deilwra i'ch moleciwlau penodol o ddiddordeb, gan gynnwys niwcleotidau, asidau amino, carbohydradau, a metabolion bach eraill. Mae ein harbenigedd yn galluogi datblygu profion cadarn, sensitif a meintiol sydd wedi'u cynllunio i ddiwallu anghenion eich ymchwil.
Rydym yn darparu gwasanaeth cynhwysfawr o'r diwedd i'r diwedd, o baratoi samplau a sbectrometreg màs meintiol i brosesu data, dadansoddiad ystadegol, a dehongli biolegol - gan eich helpu i gynhyrchu data gweithredadwy o ansawdd uchel ar gyfer eich ymchwil.
Cyfleuster Moleciwlau Bach Caerdydd - Ymchwil - Prifysgol Caerdydd
Sbectrometreg màs a chromatograffeg
Mae ein cyfleuster yn gartref i ddau sbectromedr màs sydd wedi'u hanelu'n llawn at ddadansoddi lipidomig a moleciwlau bach.
Mae technegau ar gael i wahanu, adnabod a meintioli cymysgeddau cymhleth o metabolion o ystod eang o samplau biolegol.
Ein profion gradd ymchwil
- Oxylipins (eicosanoids, prostaglandins, leukotrienes)
- Esterau colesterol a cholesterol
- Ffosffolipidau brodorol (PC, PE, PI, PS, Lyso PC/PE/PI/PS)
- Ffosffolipidau ocsidedig
- Sphingomyelins
- Ceramidau
- Asidau brasterog
- Oes gennych chi ddiddordeb mewn moleciwlau bach eraill? Gallwn gynnig gwasanaeth pwrpasol i sefydlu profion meintiol ar gyfer eich metabolion o ddiddordeb.
Offer
Prosesu sampl
- Mae cymorth technegydd ar gael i dynnu metabolion o'ch samplau biolegol gan ddefnyddio protocolau optimeiddio.
- Mae technoleg Beadruptor ar gael sy'n ein galluogi i brosesu ystod eang o feinweoedd, gan gynnwys esgyrn.
LC / MS
Sbectrometreg màs trap Quad Q triphlyg
- Sciex 6500 Q trap (ïoneiddio ES)
- Trap Sciex 7500 Q (ïoneiddio ES)
Gwasanaethau dadansoddol a thechnegol
Rydym yn darparu gwasanaethau dadansoddol a thechnegol trwy ein harbenigwyr mewn caffael a dehongli data gyda mynediad at ystod amrywiol o offer dadansoddol.
P'un a yw'n ddadansoddiad o un sampl yn unig sydd ei angen, neu ddadansoddiad mwy cynhwysfawr o lawer o samplau gan ddefnyddio technegau lluosog, rydym mewn sefyllfa ddelfrydol i ddarparu'r atebion sydd eu hangen arnoch.
Efallai eich bod chi'n biocemegydd profiadol ac yn gwybod yn union y wybodaeth rydych chi ei eisiau, ond os na, gallem eich helpu i nodi'r hyn y mae angen i chi ei wybod a sut i gyflawni eich nodau.
I drafod eich gofynion, cysylltwch â:
Dr Victoria Tyrrell
Rheolwr Cyfleuster Lipidomics
+44 (0)29 2068 7309
[email protected]
Bywgraffiad
Rwy'n rheoli'r cyfleuster sbectrometreg màs lipidomeg ym Mhrifysgol Caerdydd, wedi'i ymgorffori yng ngrŵp ymchwil yr Athro Valerie O'Donnell yn yr Ysgol Meddygaeth. Rwyf wedi bod yn gweithio gyda llwyfannau Cwad Triphlyg Sciex ers 15 mlynedd, gan redeg profion lipidomeg wedi'u targedu gan MRM mewn llu o samplau biolegol a biohylifau. Mae gennym yr offer i homogeneiddio meinweoedd, caniatáu hyblygrwydd i ni yn y mathau o samplau y gallwn eu dadansoddi ac maent yn arbenigwyr ar drin samplau a meintioli lipid.
Contact Details
Themâu ymchwil
Arbenigeddau
- Lipids
- Lipidomeg
- LC-MS/MS