Dr Victoria Tyrrell

2024

• Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(9), pp. 2038-2052. (10.1161/ATVBAHA.124.320902)

2023

• Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)

2022

• Brown, J. L. et al. 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57, article number: 102518. (10.1016/j.redox.2022.102518)
• Brown, J., Edmonds, A., O’Donnell, V., Tyrrell, V. and Van Remmen, H. 2022. The role of oxylipins in muscle atrophy. Free Radical Biology and Medicine 192(S1), pp. 16-17. (10.1016/j.freeradbiomed.2022.10.009)
• Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
• Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)

2021

• Diskin, C., Zotta, A., Corcoran, S. E., Tyrrell, V. J., Zaslona, Z., O'Donnell, V. B. and O'Neill, L. A. J. 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207(10), pp. 2561-2569. (10.4049/jimmunol.2100488)
• Diskin, C. et al. 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207(10), pp. 2551-2560. (10.4049/jimmunol.2100402)
• Contursi, A. et al. 2021. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. Journal of Lipid Research 62, article number: 100109. (10.1016/j.jlr.2021.100109)
• Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
• Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)

2020

• Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15(10), article number: e0240189. (10.1371/journal.pone.0240189)
• Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
• Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)

2019

• Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)
• Kornilov, A. et al. 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294, pp. 9225-9238. (10.1074/jbc.RA119.008915)
• Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)

2018

• Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3(6), article number: e98459. (10.1172/jci.insight.98459)

2017

• Zhao, J. et al. 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57(6) (10.1165/rcmb.2017-0031OC)
• Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10(507), article number: eaan2787. (10.1126/scisignal.aan2787)
• Uderhardt, S. et al. 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214(7), pp. 2121-2138. (10.1084/jem.20161070)
• Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001)
• Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)

2016

• Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)

2015

• Morgan, A. H. et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005)

2014

• Mathie, S. A. et al. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70(1), pp. 80-89. (10.1111/all.12536)
• Thomas, C. P., Clark, S. R., Hammond, V. J., Aldrovandi, M., Collins, P. W. and O'Donnell, V. B. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63. (10.1038/nprot.2013.163)

2013

• Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54(11), pp. 3085-3097. (10.1194/jlr.M041533)
• Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110)

2012

• Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)
• Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818(10), pp. 2403-2412. (10.1016/j.bbamem.2011.12.013)

2011

• Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)

2010

• Jones, G. W. et al. 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184(4), pp. 2130-2139. (10.4049/jimmunol.0901528)
• Jones, G. W. et al. 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184(4), pp. 2130-2139.
• Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5(12), pp. 1919-1931. (10.1038/nprot.2010.162)

2008

• Hams, E. et al. 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.

2007

• Hams, E. et al. 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39(1), pp. 14-14. (10.1016/j.cyto.2007.07.053)