![Victoria Tyrrell](https://profiles-cardiff.imgix.net/attachments/7623?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Victoria Tyrrell
(she/her)
Teams and roles for Victoria Tyrrell
Lipidomics Facility Manager
Publication
2025
- Protty, M. B. et al. 2025. Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.. Journal of Lipid Research 66(1), article number: 100727. (10.1016/j.jlr.2024.100727)
- Ghorasaini, M., Costa, D., Tyrrell, V. J., Protty, M., Giera, M. and O'Donnell, V. B. 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology., Vol. 2855. New York, NY, USA: Springer, pp. 155-169., (10.1007/978-1-0716-4116-3_10)
2024
- Torta, F. et al. 2024. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nature Communications 15(1), article number: 8562. (10.1038/s41467-024-52087-x)
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(9), pp. 2038-2052. (10.1161/ATVBAHA.124.320902)
2023
- Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
2022
- Brown, J., Edmonds, A., O’Donnell, V., Tyrrell, V. and Van Remmen, H. 2022. The role of oxylipins in muscle atrophy. Free Radical Biology and Medicine 192(S1), pp. 16-17. (10.1016/j.freeradbiomed.2022.10.009)
- Brown, J. L. et al. 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57, article number: 102518. (10.1016/j.redox.2022.102518)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
2021
- Diskin, C. et al. 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207(10), pp. 2551-2560. (10.4049/jimmunol.2100402)
- Diskin, C., Zotta, A., Corcoran, S. E., Tyrrell, V. J., Zaslona, Z., O'Donnell, V. B. and O'Neill, L. A. J. 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207(10), pp. 2561-2569. (10.4049/jimmunol.2100488)
- Contursi, A. et al. 2021. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. Journal of Lipid Research 62, article number: 100109. (10.1016/j.jlr.2021.100109)
- Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)
2020
- Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15(10), article number: e0240189. (10.1371/journal.pone.0240189)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
2019
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)
- Kornilov, A. et al. 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294, pp. 9225-9238. (10.1074/jbc.RA119.008915)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
2018
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3(6), article number: e98459. (10.1172/jci.insight.98459)
2017
- Zhao, J. et al. 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57(6) (10.1165/rcmb.2017-0031OC)
- Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10(507), article number: eaan2787. (10.1126/scisignal.aan2787)
- Uderhardt, S. et al. 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214(7), pp. 2121-2138. (10.1084/jem.20161070)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)
2016
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
2015
- Morgan, A. H. et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005)
2014
- Mathie, S. A. et al. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70(1), pp. 80-89. (10.1111/all.12536)
- Thomas, C. P., Clark, S. R., Hammond, V. J., Aldrovandi, M., Collins, P. W. and O'Donnell, V. B. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63. (10.1038/nprot.2013.163)
2013
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54(11), pp. 3085-3097. (10.1194/jlr.M041533)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110)
2012
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818(10), pp. 2403-2412. (10.1016/j.bbamem.2011.12.013)
2011
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
2010
- Jones, G. W. et al. 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184(4), pp. 2130-2139. (10.4049/jimmunol.0901528)
- Jones, G. W. et al. 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184(4), pp. 2130-2139.
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5(12), pp. 1919-1931. (10.1038/nprot.2010.162)
2008
- Hams, E. et al. 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.
2007
- Hams, E. et al. 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39(1), pp. 14-14. (10.1016/j.cyto.2007.07.053)
Articles
- Protty, M. B. et al. 2025. Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.. Journal of Lipid Research 66(1), article number: 100727. (10.1016/j.jlr.2024.100727)
- Torta, F. et al. 2024. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nature Communications 15(1), article number: 8562. (10.1038/s41467-024-52087-x)
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(9), pp. 2038-2052. (10.1161/ATVBAHA.124.320902)
- Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
- Brown, J., Edmonds, A., O’Donnell, V., Tyrrell, V. and Van Remmen, H. 2022. The role of oxylipins in muscle atrophy. Free Radical Biology and Medicine 192(S1), pp. 16-17. (10.1016/j.freeradbiomed.2022.10.009)
- Brown, J. L. et al. 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57, article number: 102518. (10.1016/j.redox.2022.102518)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
- Diskin, C. et al. 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207(10), pp. 2551-2560. (10.4049/jimmunol.2100402)
- Diskin, C., Zotta, A., Corcoran, S. E., Tyrrell, V. J., Zaslona, Z., O'Donnell, V. B. and O'Neill, L. A. J. 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207(10), pp. 2561-2569. (10.4049/jimmunol.2100488)
- Contursi, A. et al. 2021. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. Journal of Lipid Research 62, article number: 100109. (10.1016/j.jlr.2021.100109)
- Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)
- Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15(10), article number: e0240189. (10.1371/journal.pone.0240189)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)
- Kornilov, A. et al. 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294, pp. 9225-9238. (10.1074/jbc.RA119.008915)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3(6), article number: e98459. (10.1172/jci.insight.98459)
- Zhao, J. et al. 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57(6) (10.1165/rcmb.2017-0031OC)
- Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10(507), article number: eaan2787. (10.1126/scisignal.aan2787)
- Uderhardt, S. et al. 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214(7), pp. 2121-2138. (10.1084/jem.20161070)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Morgan, A. H. et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005)
- Mathie, S. A. et al. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70(1), pp. 80-89. (10.1111/all.12536)
- Thomas, C. P., Clark, S. R., Hammond, V. J., Aldrovandi, M., Collins, P. W. and O'Donnell, V. B. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63. (10.1038/nprot.2013.163)
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54(11), pp. 3085-3097. (10.1194/jlr.M041533)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110)
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818(10), pp. 2403-2412. (10.1016/j.bbamem.2011.12.013)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
- Jones, G. W. et al. 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184(4), pp. 2130-2139. (10.4049/jimmunol.0901528)
- Jones, G. W. et al. 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184(4), pp. 2130-2139.
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5(12), pp. 1919-1931. (10.1038/nprot.2010.162)
- Hams, E. et al. 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.
- Hams, E. et al. 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39(1), pp. 14-14. (10.1016/j.cyto.2007.07.053)
Book sections
- Ghorasaini, M., Costa, D., Tyrrell, V. J., Protty, M., Giera, M. and O'Donnell, V. B. 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology., Vol. 2855. New York, NY, USA: Springer, pp. 155-169., (10.1007/978-1-0716-4116-3_10)
Research
Our research is focused on understanding the role of lipids and their metabolites in inflammation, arthritis, cardiovascular disease and thrombosis. We host a mass spectrometry facility which was established over 20 years ago.
We house two state of the art Sciex Triple Quad/QTRAP mass spectrometers coupled to Shimadzu LC systems for targeted MRM based lipidomic assays, and a Waters SynaptXS QToF for high resolution structural anaysis, coupled to DESI, EIS and SFC.
We collaborate with clinical and non-clinical researchers locally, within the UK and across the world and can provide lipidomics and small molecule measurement and quantitation through our dedicated Mass spectrometry facility
Core facility
Cardiff Small Molecules Facility - Research - Cardiff University
Mass spectrometry and chromatography
Our facility houses three mass spectrometers which are fully geared up towards lipidomic analysis.
Techniques are available to separate, identify and quantify complex mixtures of lipids from a vast range of biological samples.
Our research grade assays
- Oxylipins (eicosanoids, prostaglandins, leukotrienes)
- Cholesterol and cholesterol esters
- Native phospholipids (PC, PE, PG, PI, PS, Lyso PC/PE/PG/PI/PS)
- Oxidised phospholipids
- Sphingomyelins
- Interested in other small molecules? We can offer a bespoke service to set up quantitative assays for your metabolites of interest.
Equipment
Sample processing
- Technician support is available to extract lipids from your biological samples using optimised protocols.
- Beadruptor technology is available allowing us to process a wide range of tissues, including bone.
- The facility is equipped with a Tecan liquid handling robot for high sample throughput.
LC/MS
Triple Quad Q trap mass spectrometry
- Sciex 6500 Q trap (ES ionisation)
- Sciex 7500 Q trap (ES ionisation)
Accurate mass QToF
- Waters SynaptXS QToF (ES ionisation)
Analytical and technical services
We provide analytical and technical services through our experts in data acquisition and interpretation with access to a varied range of analytical equipment.
Whether it is just analysis of a single sample that is required, or more comprehensive analysis of many samples using multiple techniques, we are ideally placed to provide the answers you need.
You may be an experienced biochemist and know exactly the information you want, but if not, we could help you to identify what you need to know and how to achieve your aims.
To discuss your requirements, please contact:
Dr Victoria Tyrrell
Lipidomics Facility Manager
+44 (0)29 2068 7309
tyrrellvj@cardiff.ac.uk
Biography
I manage the lipidomics mass spectrometry facility at Cardiff University, embedded within the research group of Professor Valerie O'Donnell in the School of Medicine. I have been working with Sciex Triple Quad platforms for 15 years, running targeted MRM based lipidomics assays in a whole host of biological samples and biofluids. We have the equipment to homogenise tissues, allowing us flexibility in the sample types we can analyse and are experts in sample handling and lipid quantitation.
Contact Details
Research themes
Specialisms
- Lipids
- Lipidomics
- LC-MS/MS