![Eddie Wang](https://profiles-cardiff.imgix.net/attachments/2634?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Eddie Wang
- Sylwebydd y cyfryngau
Timau a rolau for Eddie Wang
Athro Imiwnoleg Feirysol
Trosolwyg
Rwy'n Athro Imiwnoleg Firaol o fewn Grŵp Ymchwil 'Imiwnoleg Firaol' (VIRG) yr Is-adran Heintiau ac Imiwnedd, Ysgol Feddygaeth, Coleg y Gwyddorau Biofeddygol a Bywyd. Mae fy ymchwil yn cwmpasu'r bioleg a'r imiwnoleg gellog sy'n ymwneud â Cytomegalofirws Dynol (HCMV) a swyddogaeth fiolegol Derbynnydd Marwolaeth 3, aelod o'r uwch-deulu TNFR sy'n ymwneud â rheoli clefyd llidiol ac awtoimiwn. Mae rhagor o fanylion am waith HCMV i'w gweld ar dudalen we VIRG (https://www.cardiff.ac.uk/research/explore/research-units/viral-immunology-research-group).
Mae rhagor o fanylion am gyhoeddiadau ar gael ar Researchgate (https://www.researchgate.net/profile/Eddie_Wang) a Google Scholar (https://scholar.google.co.uk/citations?hl=en&user=DgvpthYAAAAJ)
Aelodaeth Broffesiynol
- Cymdeithas Imiwnoleg Prydain
- Cymdeithas Microbioleg
- Cynghorydd Gwyddonol ar gyfer Labordai Shattuck
Pwyllgorau'r Brifysgol
- Aelod o Fenter Athrawon Lleiafrifoedd Ethnig Cymru (WEMPI)
- Aelod o'r Sefydliad Ymchwil Prifysgol Imiwnedd Systemau (SIURI)
- Swyddog Meinweoedd Dynol ar gyfer Adeilad Henry Wellcome, Is-adran Heintiau ac Imiwnedd (hyd at 2025)
- Aelod o Bwyllgor Llywodraethu Ymchwil HTA Prifysgol Caerdydd (hyd at 2025)
- Thema Osgoi Imiwnedd Caerdydd ar y cyd arweinydd ar gyfer Consortiwm Imiwnoleg Coronafeirws y DU (UK-CIC)
- Cynllun GW4-PhD Panel rhestr fer/cyfweliad thema Heintiau, Imiwnedd a Thrwsio 2020/21
Cyhoeddiad
2025
- Preston, H. et al. 2025. Human cytomegalovirus immune evasion of natural killer cells: a virus for all seasons?. Pathogens 14(7), article number: 629. (10.3390/pathogens14070629)
- Davies, K. et al. 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology
2024
- Litvin, U., Wang, E. C., Stanton, R. J., Fielding, C. A. and Hughes, J. 2024. Evolution of the cytomegalovirus RL11 gene family in old world monkeys and great apes. Virus Evolution 10(1), article number: veae066. (10.1093/ve/veae066)
- Kite, J., Hill, M., Preston, N., Rubina, A., Kollnberger, S., Wang, E. C. Y. and Elliott, G. 2024. Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function. Journal of General Virology 105(3) (10.1099/jgv.0.001969)
2023
- Vlachava, V. et al. 2023. HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation. Proceedings of the National Academy of Sciences 120(49), article number: e2309077120. (10.1073/pnas.2309077120)
- Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Luo, S., Liman, N., Li, C., Crossman, A., Wang, E. C. Y., Meylan, F. and Park, J. 2023. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. Cellular and Molecular Life Sciences 80(3), pp. 1-12., article number: 76. (10.1007/s00018-023-04726-7)
2022
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
- Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
- Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
- Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)
2021
- Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
- Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
2020
- Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
- Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
- Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)
2019
- Collins, F. L., Stone, M. D., Turton, J., McCabe, L. R., Wang, E. C. and Williams, A. S. 2019. Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels. BMC Musculoskeletal Disorders 20(1), article number: 326. (10.1186/s12891-019-2704-z)
- Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)
2018
- Boelen, L. et al. 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3(29), article number: eaao2892. (10.1126/sciimmunol.aao2892)
- Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
- Malhotra, N. et al. 2018. RORα-expressing T regulatory cells restrain allergic skin inflammation. Science Immunology 3(21), article number: eaao6923. (10.1126/sciimmunol.aao6923)
2017
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Collins, F. L. et al. 2017. CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone 97, pp. 94-104. (10.1016/j.bone.2017.01.002)
2016
- Williams, A., Wang, E. C. Y., Thurner, L. and Liu, C. 2016. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis & Rheumatology 68(12), pp. 2845-2856. (10.1002/art.39816)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021)
- Jia, L., Bamias, G., Burkly, L. C., Wang, E. C. Y., Gruszka, D., Pizarro, T. T. and Cominelli, F. 2016. A novel role for TL1A/DR3 in protection against intestinal injury and infection. Journal of Immunology 197(1), pp. 377-386. (10.4049/jimmunol.1502466)
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
2015
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Collins, F. L., Williams, J., Bloom, A. C., Stone, M. D., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2015. Death Receptor 3 (TNFRSF25) Increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice. Journal of Immunology Research 2015, pp. -., article number: 901679. (10.1155/2015/901679)
2014
- Wang, E. C. Y. et al. 2014. Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis and Rheumatology 66(10), pp. 2762-2772. (10.1002/art.38770)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
2013
- Pembroke, T., Christian, A., Jones, E., Hills, R. K., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a (10.1136/gutjnl-2013-304472)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
2012
- Collins, F., Stone, M. D., Goodfellow, R. M., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2012. TNF-like protein 1A/death receptor 3 pathway regulates osteoclastogenesis and is associated with erosive disease in rheumatoid arthritis. Arthritis and Rheumatism 64(10), pp. S768-S768.
- Wang, E. C. Y. 2012. On death receptor 3 and its ligands... Immunology 137(1), pp. 114-116. (10.1111/j.1365-2567.2012.03606.x)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42(9), pp. 2383-2394. (10.1002/eji.201142072)
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26(9), pp. 2146-2148. (10.1038/leu.2012.75)
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26(9), pp. 2148-2151. (10.1038/leu.2012.77)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26(8), pp. 3575-3586. (10.1096/fj.11-200618)
- Pembroke, T., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61(S2), pp. A144-A145. (10.1136/gutjnl-2012-302514b.174)
- Collins, F., Stone, M., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and tl1a: A regulatory pathway of bone turnover and target for osteoporosis therapy? [Abstract]. Osteoporosis International 23, pp. S528-S528.
- Calder, C. J. and Wang, E. C. Y. 2012. An essential role for death receptor 3 in experimental autoimmune uveoretinitis [Letter]. Ocular Immunology and Inflammation 20(3), pp. 212-214. (10.3109/09273948.2012.658135)
- Collins, F., Stone, M. D., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and Tl1a: A driving force in osteoclast differentiation and potential target for rheumatoid arthritis therapy [Abstract]. Rheumatology 51(s3), pp. 140-140. (10.1093/rheumatology/kes108)
- Al-Lamki, R. S., Lu, W., Finlay, S., Twohig, J. P., Wang, E. C. Y., Tolkovsky, A. M. and Bradley, J. R. 2012. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. American Journal of Pathology 180(4), pp. 1454-1464. (10.1016/j.ajpath.2012.01.003)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
2011
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135(S1), pp. 178. (10.1111/j.1365-2567.2011.03534.x)
- Wang, E. C. Y. et al. 2011. Control of early cartilage destruction in inflammatory arthritis by death receptor 3 [Abstract]. Immunology 135(s1), pp. 153-153. (10.1111/j.1365-2567.2011.03534.x)
- Stacey, M. A., Marsden, M., Wang, E. C. Y., Wilkinson, G. W. G. and Humphreys, I. R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187(6), pp. 2944-2952. (10.4049/jimmunol.1101021)
- Coles, S., Wang, E. C. Y., Man, S. T., Hills, R. K., Burnett, A. K., Tonks, A. and Darley, R. L. 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25(5), pp. 792-799. (10.1038/leu.2011.1)
- Jones, G. W. et al. 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25(1), pp. 409-419. (10.1096/fj.10-166843)
- Wang, E. C. Y. 2011. CD4+ T cells, human cytomegalovirus and end-stage renal disease. Nephrology Dialysis Transplantation 26(5), pp. 1467-1470. (10.1093/ndt/gfr167)
2010
- Williams, A. S., Collins, F., Newton, Z., Goodfellow, R. M., Rajak, R., Calder, C. J. and Wang, E. C. Y. 2010. Death Receptor 3 orchestrates erosive pathology in inflammatory arthritis [Poster Abstract]. Immunology 131(s1), pp. 53-53. (10.1111/j.1365-2567.2010.03390.x)
- Jones, G. W. et al. 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131(s1), pp. 102-102. (10.1111/j.1365-2567.2010.03390.x)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116(21), pp. 218-218.
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
- Taraban, V. et al. 2010. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology 4(2), pp. 186-196. (10.1038/mi.2010.70)
2009
- Williams, A. S. et al. 2009. A functional role for death receptor-3 in arthritis [Abstract]. Cytokine 48(1-2), pp. 134-134. (10.1016/j.cyto.2009.07.568)
- Twohig, J. P. et al. 2009. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology 46(10), pp. 2002-2013. (10.1016/j.molimm.2009.03.007)
- Newton, Z., Bull, M., Wang, E. C. Y. and Williams, A. S. 2009. The role of dr3/tl1a in cartilage depletion caused by inflammatory arthritis [Abstract]. Rhuematology 48(s1), pp. I30-I30. (10.1093/rheumatology/kep713)
- Williams, A. S. et al. 2009. Functional role of dr3 in inflammatory arthritis: A novel target for therapy? [Abstract]. Rheumatology 48(s1), pp. I8-I8. (10.1093/rheumatology/kep704)
2008
- Jones, G. W. et al. 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125(s1), pp. 62-62. (10.1111/j.1365-2567.2008.02974.x)
- Williams, A. S. et al. 2008. The role of death receptor 3 in inflammatory arthritis [Abstract]. Immunology 125, pp. 34-34. (10.1111/j.1365-2567.2008.02974.x)
- Bull, M. J. et al. 2008. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. Journal of Experimental Medicine 205(11), pp. 2457-2464. (10.1084/jem.20072378)
- Meylan, F. et al. 2008. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1), pp. 79-89. (10.1016/j.immuni.2008.04.021)
- Al-Lamki, R. S. et al. 2008. TL1A both promotes and protects from renal inflammation and injury. Journal of the American Society of Nephrology 19(5), pp. 953-960. (10.1681/ASN.2007060706)
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
- Chong, L. K., Aicheler, R., Llewellyn-Lacey, S., Tomasec, P., Brennan, P. and Wang, E. C. Y. 2008. Proliferation and interleukin 5 production by CD8hiCD57+ T cells. European Journal of Immunology 38(4), pp. 995-1000. (10.1002/eji.200737687)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
2007
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Jones, G. W. et al. 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39(1), pp. 18-19.
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
2006
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. The Journal of Immunology 176(5), pp. 2915-2923. (10.4049/jimmunol.176.5.2915)
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Journal of immunology 176(5), pp. 2915-2923.
2005
- Griffin, C., Wang, E. C. Y., McSharry, B. P., Rickards, C. R., Browne, H., Wilkinson, G. W. G. and Tomasec, P. 2005. Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18. Journal of General Virology 86(11), pp. 2999-3008. (10.1099/vir.0.81126-0)
- Siebert, S., Amos, N., Fielding, C. A., Wang, E. C. Y., Aksentijevich, I., Williams, B. D. and Brennan, P. 2005. Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Arthritis & Rheumatism 52(4), pp. 1287-1282. (10.1002/art.20955)
- Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)
- Vedhara, K. and Wang, E. C. Y. 2005. Assessment of the immune system in human psychoneuroimmunology. In: Vedhara, K. and Irwin, M. R. eds. Human Psychneuroimmunology. Oxford: Oxford University Press, pp. 53-80.
2002
- Wang, E. C. Y. et al. 2002. UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proceedings of the National Academy of Sciences 99(11), pp. 7570-7575. (10.1073/pnas.112680099)
2001
- Wang, E. C. Y., Thern, A., Denzel, A., Kitson, J., Farrow, S. N. and Owen, M. J. 2001. DR3 regulates negative selection during thymocyte development. Molecular and cellular biology 21(10), pp. 3451-61. (10.1128/MCB.21.10.3451-3461.2001)
- Wang, E. C. Y., Kitson, J., Thern, A., Williamson, J., Farrow, S. N. and Owen, M. J. 2001. Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 53(1), pp. 59-63. (10.1007/s002510000290)
- Lawson, T. et al. 2001. Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR. International Immunology 13(11), pp. 1383-1390. (10.1093/intimm/13.11.1383)
1998
- Wang, E. C. Y. 1998. Sorting of human peripheral blood T-cell subsets using immunomagnetic beads. In: Pound, J. D. ed. Immunochemical Protocols., Vol. 80. Methods in Molecular Biology Vol. 2. Humana Press, pp. 365-376., (10.1007/978-1-59259-257-9_37)
1992
- Wang, E. C. Y., Borysiewicz, L. K. and Weetman, A. P. 1992. Cell sorting using immunomagnetic beads. In: Manson, M. M. ed. Immunochemical Protocols. Methods in Molecular Biology Vol. 10. Totowa, NJ: Humana Press, pp. 347-358.
Articles
- Preston, H. et al. 2025. Human cytomegalovirus immune evasion of natural killer cells: a virus for all seasons?. Pathogens 14(7), article number: 629. (10.3390/pathogens14070629)
- Davies, K. et al. 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology
- Litvin, U., Wang, E. C., Stanton, R. J., Fielding, C. A. and Hughes, J. 2024. Evolution of the cytomegalovirus RL11 gene family in old world monkeys and great apes. Virus Evolution 10(1), article number: veae066. (10.1093/ve/veae066)
- Kite, J., Hill, M., Preston, N., Rubina, A., Kollnberger, S., Wang, E. C. Y. and Elliott, G. 2024. Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function. Journal of General Virology 105(3) (10.1099/jgv.0.001969)
- Vlachava, V. et al. 2023. HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation. Proceedings of the National Academy of Sciences 120(49), article number: e2309077120. (10.1073/pnas.2309077120)
- Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Luo, S., Liman, N., Li, C., Crossman, A., Wang, E. C. Y., Meylan, F. and Park, J. 2023. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. Cellular and Molecular Life Sciences 80(3), pp. 1-12., article number: 76. (10.1007/s00018-023-04726-7)
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
- Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
- Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
- Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)
- Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
- Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
- Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
- Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
- Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)
- Collins, F. L., Stone, M. D., Turton, J., McCabe, L. R., Wang, E. C. and Williams, A. S. 2019. Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels. BMC Musculoskeletal Disorders 20(1), article number: 326. (10.1186/s12891-019-2704-z)
- Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)
- Boelen, L. et al. 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3(29), article number: eaao2892. (10.1126/sciimmunol.aao2892)
- Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
- Malhotra, N. et al. 2018. RORα-expressing T regulatory cells restrain allergic skin inflammation. Science Immunology 3(21), article number: eaao6923. (10.1126/sciimmunol.aao6923)
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Collins, F. L. et al. 2017. CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone 97, pp. 94-104. (10.1016/j.bone.2017.01.002)
- Williams, A., Wang, E. C. Y., Thurner, L. and Liu, C. 2016. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis & Rheumatology 68(12), pp. 2845-2856. (10.1002/art.39816)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021)
- Jia, L., Bamias, G., Burkly, L. C., Wang, E. C. Y., Gruszka, D., Pizarro, T. T. and Cominelli, F. 2016. A novel role for TL1A/DR3 in protection against intestinal injury and infection. Journal of Immunology 197(1), pp. 377-386. (10.4049/jimmunol.1502466)
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Collins, F. L., Williams, J., Bloom, A. C., Stone, M. D., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2015. Death Receptor 3 (TNFRSF25) Increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice. Journal of Immunology Research 2015, pp. -., article number: 901679. (10.1155/2015/901679)
- Wang, E. C. Y. et al. 2014. Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis and Rheumatology 66(10), pp. 2762-2772. (10.1002/art.38770)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
- Pembroke, T., Christian, A., Jones, E., Hills, R. K., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a (10.1136/gutjnl-2013-304472)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
- Collins, F., Stone, M. D., Goodfellow, R. M., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2012. TNF-like protein 1A/death receptor 3 pathway regulates osteoclastogenesis and is associated with erosive disease in rheumatoid arthritis. Arthritis and Rheumatism 64(10), pp. S768-S768.
- Wang, E. C. Y. 2012. On death receptor 3 and its ligands... Immunology 137(1), pp. 114-116. (10.1111/j.1365-2567.2012.03606.x)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42(9), pp. 2383-2394. (10.1002/eji.201142072)
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26(9), pp. 2146-2148. (10.1038/leu.2012.75)
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26(9), pp. 2148-2151. (10.1038/leu.2012.77)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26(8), pp. 3575-3586. (10.1096/fj.11-200618)
- Pembroke, T., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61(S2), pp. A144-A145. (10.1136/gutjnl-2012-302514b.174)
- Collins, F., Stone, M., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and tl1a: A regulatory pathway of bone turnover and target for osteoporosis therapy? [Abstract]. Osteoporosis International 23, pp. S528-S528.
- Calder, C. J. and Wang, E. C. Y. 2012. An essential role for death receptor 3 in experimental autoimmune uveoretinitis [Letter]. Ocular Immunology and Inflammation 20(3), pp. 212-214. (10.3109/09273948.2012.658135)
- Collins, F., Stone, M. D., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and Tl1a: A driving force in osteoclast differentiation and potential target for rheumatoid arthritis therapy [Abstract]. Rheumatology 51(s3), pp. 140-140. (10.1093/rheumatology/kes108)
- Al-Lamki, R. S., Lu, W., Finlay, S., Twohig, J. P., Wang, E. C. Y., Tolkovsky, A. M. and Bradley, J. R. 2012. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. American Journal of Pathology 180(4), pp. 1454-1464. (10.1016/j.ajpath.2012.01.003)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135(S1), pp. 178. (10.1111/j.1365-2567.2011.03534.x)
- Wang, E. C. Y. et al. 2011. Control of early cartilage destruction in inflammatory arthritis by death receptor 3 [Abstract]. Immunology 135(s1), pp. 153-153. (10.1111/j.1365-2567.2011.03534.x)
- Stacey, M. A., Marsden, M., Wang, E. C. Y., Wilkinson, G. W. G. and Humphreys, I. R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187(6), pp. 2944-2952. (10.4049/jimmunol.1101021)
- Coles, S., Wang, E. C. Y., Man, S. T., Hills, R. K., Burnett, A. K., Tonks, A. and Darley, R. L. 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25(5), pp. 792-799. (10.1038/leu.2011.1)
- Jones, G. W. et al. 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25(1), pp. 409-419. (10.1096/fj.10-166843)
- Wang, E. C. Y. 2011. CD4+ T cells, human cytomegalovirus and end-stage renal disease. Nephrology Dialysis Transplantation 26(5), pp. 1467-1470. (10.1093/ndt/gfr167)
- Williams, A. S., Collins, F., Newton, Z., Goodfellow, R. M., Rajak, R., Calder, C. J. and Wang, E. C. Y. 2010. Death Receptor 3 orchestrates erosive pathology in inflammatory arthritis [Poster Abstract]. Immunology 131(s1), pp. 53-53. (10.1111/j.1365-2567.2010.03390.x)
- Jones, G. W. et al. 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131(s1), pp. 102-102. (10.1111/j.1365-2567.2010.03390.x)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116(21), pp. 218-218.
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
- Taraban, V. et al. 2010. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology 4(2), pp. 186-196. (10.1038/mi.2010.70)
- Williams, A. S. et al. 2009. A functional role for death receptor-3 in arthritis [Abstract]. Cytokine 48(1-2), pp. 134-134. (10.1016/j.cyto.2009.07.568)
- Twohig, J. P. et al. 2009. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology 46(10), pp. 2002-2013. (10.1016/j.molimm.2009.03.007)
- Newton, Z., Bull, M., Wang, E. C. Y. and Williams, A. S. 2009. The role of dr3/tl1a in cartilage depletion caused by inflammatory arthritis [Abstract]. Rhuematology 48(s1), pp. I30-I30. (10.1093/rheumatology/kep713)
- Williams, A. S. et al. 2009. Functional role of dr3 in inflammatory arthritis: A novel target for therapy? [Abstract]. Rheumatology 48(s1), pp. I8-I8. (10.1093/rheumatology/kep704)
- Jones, G. W. et al. 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125(s1), pp. 62-62. (10.1111/j.1365-2567.2008.02974.x)
- Williams, A. S. et al. 2008. The role of death receptor 3 in inflammatory arthritis [Abstract]. Immunology 125, pp. 34-34. (10.1111/j.1365-2567.2008.02974.x)
- Bull, M. J. et al. 2008. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. Journal of Experimental Medicine 205(11), pp. 2457-2464. (10.1084/jem.20072378)
- Meylan, F. et al. 2008. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1), pp. 79-89. (10.1016/j.immuni.2008.04.021)
- Al-Lamki, R. S. et al. 2008. TL1A both promotes and protects from renal inflammation and injury. Journal of the American Society of Nephrology 19(5), pp. 953-960. (10.1681/ASN.2007060706)
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
- Chong, L. K., Aicheler, R., Llewellyn-Lacey, S., Tomasec, P., Brennan, P. and Wang, E. C. Y. 2008. Proliferation and interleukin 5 production by CD8hiCD57+ T cells. European Journal of Immunology 38(4), pp. 995-1000. (10.1002/eji.200737687)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Jones, G. W. et al. 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39(1), pp. 18-19.
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. The Journal of Immunology 176(5), pp. 2915-2923. (10.4049/jimmunol.176.5.2915)
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Journal of immunology 176(5), pp. 2915-2923.
- Griffin, C., Wang, E. C. Y., McSharry, B. P., Rickards, C. R., Browne, H., Wilkinson, G. W. G. and Tomasec, P. 2005. Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18. Journal of General Virology 86(11), pp. 2999-3008. (10.1099/vir.0.81126-0)
- Siebert, S., Amos, N., Fielding, C. A., Wang, E. C. Y., Aksentijevich, I., Williams, B. D. and Brennan, P. 2005. Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Arthritis & Rheumatism 52(4), pp. 1287-1282. (10.1002/art.20955)
- Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)
- Wang, E. C. Y. et al. 2002. UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proceedings of the National Academy of Sciences 99(11), pp. 7570-7575. (10.1073/pnas.112680099)
- Wang, E. C. Y., Thern, A., Denzel, A., Kitson, J., Farrow, S. N. and Owen, M. J. 2001. DR3 regulates negative selection during thymocyte development. Molecular and cellular biology 21(10), pp. 3451-61. (10.1128/MCB.21.10.3451-3461.2001)
- Wang, E. C. Y., Kitson, J., Thern, A., Williamson, J., Farrow, S. N. and Owen, M. J. 2001. Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 53(1), pp. 59-63. (10.1007/s002510000290)
- Lawson, T. et al. 2001. Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR. International Immunology 13(11), pp. 1383-1390. (10.1093/intimm/13.11.1383)
Book sections
- Vedhara, K. and Wang, E. C. Y. 2005. Assessment of the immune system in human psychoneuroimmunology. In: Vedhara, K. and Irwin, M. R. eds. Human Psychneuroimmunology. Oxford: Oxford University Press, pp. 53-80.
- Wang, E. C. Y. 1998. Sorting of human peripheral blood T-cell subsets using immunomagnetic beads. In: Pound, J. D. ed. Immunochemical Protocols., Vol. 80. Methods in Molecular Biology Vol. 2. Humana Press, pp. 365-376., (10.1007/978-1-59259-257-9_37)
- Wang, E. C. Y., Borysiewicz, L. K. and Weetman, A. P. 1992. Cell sorting using immunomagnetic beads. In: Manson, M. M. ed. Immunochemical Protocols. Methods in Molecular Biology Vol. 10. Totowa, NJ: Humana Press, pp. 347-358.
Ymchwil
THEMÂU YMCHWIL
Rwyf wedi cael diddordeb hirsefydlog mewn cytomegalofirws dynol (HCMV), herpesfirws sy'n brif achos heintus annormaleddau cynhenid ac sy'n achosi clefyd sy'n peryglu bywyd mewn derbynwyr trawsblaniadau imiwnosuppressed a chleifion AIDS. Mae HCMV yn heintio am oes ac yn olio'r system imiwnedd; Adroddais yn wreiddiol ar natur oligoclonaidd ehangiadau celloedd T CD8 + CD57 + sy'n gysylltiedig â haint HCMV dros 25 mlynedd yn ôl (1-3). Rwyf wedi gwneud cyfraniad sylweddol i'n dealltwriaeth o osgoi imiwnedd HCMV gan gynnal nifer o ymchwil MRC a grantiau rhaglen Wellcome Trust i astudio hyn ers hynny. Peter Tomasec, Gavin Wilkinson a minnau oedd y cyntaf i ddiffinio swyddogaeth osgoi NK firaol yn llawn (HCMV UL40) (4, 5). Wrth archwilio gwahaniaethau rhwng straen HCMV labordy a chlinigol gyda Richard Stanton, fe wnaethom nodi ymhellach UL135, UL141, UL142 (gyda Mark Wills, Caergrawnt) ac UL148 fel swyddogaethau osgoi NK newydd (6-9). Wrth ail-werthuso'r homolog HLA-I UL18, gwnaethom ddangos bod UL18 yn darparu ar gyfer ataliad NK sy'n ddibynnol ar LIR1 (10) ac yn nodi US18 ac US20 fel yr imiwnoevasinau HCMV dominyddol sy'n gyfrifol am atal y ligandau actifadu celloedd NK MICA a B7-H6 (11, 12). Mae'r ymchwil fwyaf diweddar wedi dangos bod targedu ADAM17 gan UL148 ac UL148D yn newid proteom wyneb celloedd heintiedig yn ddwfn ac yn atal celloedd NK yn anuniongyrchol (13), tra bod y protein UL4 hydawdd yn blocio ymsefydlu marwolaeth celloedd a actifadu NK a chyfryngir gan TRAIL (14). Mae hyn yn cynrychioli ~ hanner yr holl atalyddion NK hysbys wedi'u hamgodio gan HCMV (15, 16). Arweiniodd fy hanes ym maes osgoi imiwnedd at gael ei gynnwys fel arweinydd ar y cyd yng Nghaerdydd ar gyfer y thema Osgoi Imiwnedd ar gyfer Consortiwm Imiwnoleg Coronafeirws y DU (UK-CIC) sy'n astudio imiwnopatholeg SARS-CoV-2.
Rwyf hefyd wedi gwneud cyfraniad sylweddol i faes ymchwil Death Receptor 3 (DR3). Mae DR3 yn aelod o'r Tumorour Necrosis Factor Receptor Superfamily sy'n ymwneud â rheoleiddio imiwnedd. Fe wnes i gynhyrchu'r unig lygoden DR3ko hysbys (17), gan sefydlu swyddogaeth hanfodol DR3 mewn clefydau llidiol / awtoimiwn yn amrywio o arthritis llidiol (18) i glefyd llidiol y coluddyn (19) ac imiwnedd gwrthfeirysol (20) trwy reoli celloedd T (21, 22) a swyddogaeth myeloid (18, 23).
CYLLID CYFREDOL (grantiau mawr yn unig)
Dyfarnwyd Gwobr Darganfod Ymddiriedolaeth Wellcome 2025-2033 "Dadansoddiad systematig o osgoi imiwnedd cytomegalofirws dynol" i M Weekes (Arweinydd, Prifysgol Caergrawnt), E Wang, R Stanton. £3,803,491
Dyfarnwyd Gwobr y Sefydliad Iechyd Cenedlaethol 2025-2030 "ADCC SCV2" i R Stanton (Arweinydd), C Fielding, V Zelek, E Wang, J Orange (Prifysgol Columbia), S Graham, M Weekes (Prifysgol Caergrawnt). ~ £ 1.500.000
Dyfarnwyd Grant Prosiect MRC 2025-2028 "Targedu coronafirysau trwy fecanweithiau sy'n ddibynnol ar Fc" i R Stanton (Arweinydd), C Fielding, E Wang, I Humphreys. (£907,456)
2023-2030 Gwobr Darganfod Ymddiriedolaeth Wellcome "Manteisio ar ymatebion imiwnedd gwrthfeirysol newydd" a ddyfarnwyd i R Stanton (Arweinydd), E Wang (£1,976,186)
2023-2027 Dyfarnwyd Astudiaethau GW4-PhD "Cynhyrchu celloedd lladdwr ar gyfer imiwnotherapi yn erbyn canser a phathogenauau" i E Wang (Arweinydd), M Heinrich-Sevcenco, R Stanton, L Wooldridge (Bryste) (£114,536)
2021-2027 Technegydd 5 mlynedd wedi'i ariannu drwy gydweithio ar SIA Ymddiriedolaeth Wellcome a ddyfarnwyd i Ben Willcox (Prifysgol Birmingham) "Archwilio paradeimau celloedd T gama delta cynhenid ac addasol mewn iechyd a chlefydau" (~£2m, £379,510 ohono i Gaerdydd)
CYLLID HANESYDDOL (grantiau mawr yn unig)
Dyfarnwyd Grant Prosiect KRUK 2022-2025 "Nodi ffactorau risg mewn cleifion trawsblaniad arennau ar gyfer clefyd a achosir gan haint cytomegalofirws dynol" i E Wang (PI), R Stanton, S Griffin (£209,986)
Dyfarnwyd Grant Prosiect MRC 2020-2025 "Nodweddu dosbarth newydd o imiwnoevasin celloedd lladdwr naturiol" i E Wang (PI), R Stanton, D Price, S Kollnberger (£819,703)
Dyfarnwyd Grant Prosiect NIHR 2021-2023 "Penderfynyddion imiwnolegol a firolegol COVID hir" i D Price (PI), H Davies, I Humphreys, P Morgan, R Stanton, E Wang (£744,457)
Dyfarnwyd Grant Prosiect MRC 2019-2023 "Rôl gwrthgyrff wrth alluogi rheoli haint HCMV gan gelloedd" i R Stanton (PI), E Wang (£762,492)
Dyfarnwyd Grant Cydweithredu Ymddiriedolaeth Wellcome 2017-2023 "Analysis of cytomegalovirus pathogenesis in a human challenge system" i P Griffiths (Coleg Prifysgol Llundain). Wang wedi'i enwi yn gydweithiwr (~£1.7m, £329,728 ohono i Gaerdydd ar gyfer PDRA)
Dyfarnwyd Grant Ymchwil MRC 2020-2021 "Platfform sylfaenol y DU i astudio imiwnoleg ac imiwnopatholeg COVID-19: Consortiwm Imiwnoleg Coronafeirws y DU" i P Moss (Prifysgol Birmingham) a 73 o Gyd-Ymchwilwyr eraill ledled y DU gan gynnwys E Wang (~£8m, £300,000 ohono i Gaerdydd ar gyfer 3 swydd mewn labordai gwahanol)
Dyfarnwyd Grant Prosiect MRC 2017-2021 "Nodweddu systematig y parth pathogenedd HCMV a gollwyd yn ddigymell o straen a ddefnyddir yn gyffredin" i E Wang (PI - unig ddeiliad), G Wilkinson (wedi ymddeol), P Tomasec (ymadawedig) (£956,196)
Dyfarnwyd Grant Rhaglen Ymddiriedolaeth Wellcome 2010-2018 "Modiwleiddio imiwnedd lletyol gan cytomegalofirws dynol" i G Wilkinson (PI), E Wang, P Tomasec (£1,062,032)
Dyfarnwyd Grant Prosiect MRC 2014-2018 "Ymchwiliad systematig i swyddogaeth genynnau cytomegalofirws dynol" i G Wilkinson (PI), E Wang, P Tomasec (£679,426)
Dyfarnwyd Grant Prosiect MRC 2010-2013 "Dadansoddiad o cytomegalofirws dynol math gwyllt" i G Wilkinson (PI), E Wang, P Tomasec (£901,468)
2009-2013 Grant Prosiect MRC "Ymchwilio i fodiwleiddio imiwnedd i haint firaol parhaus gan lwybr 1A derbynnydd marwolaeth 3/TNF" a ddyfarnwyd i E Wang (PI), I Humphreys (£467,078)
Dyfarnwyd Grant Prosiect MRC 2007-2010 "Modiwleiddio celloedd lladdwr naturiol gan cytomegalofirws dynol" i G Wilkinson (PI), E Wang, P Tomasec (£668,526)
Dyfarnwyd Grant Cydweithredu MRC 2006-2009 "Adnodd imiwnoleg gellog a firaol yng Ngholeg Meddygaeth Cymru, Prifysgol Caerdydd" i E Wang (PI), A Gallimore (£188,888)
Dyfarnwyd Grant Sefydlu Gyrfa MRC 2004-2009 "Rôl derbynnydd marwolaeth 3 mewn swyddogaeth celloedd T CD8+ ymylol" i E Wang (unig ddeiliad) (£643,596)
Dyfarnwyd Grant Rhaglen Ymddiriedolaeth Wellcome 2004-2009 "Modiwleiddio imiwnedd gan cytomegalofirws dynol" i G Wilkinson (PI), E Wang, P Tomasec (£789,117)
2004-2007 Dyfarnwyd Grant Prosiect Ymddiriedolaeth Wellcome "Immune evasion by Epstein Barr virus" i M Rowe (PI), E Wang (£304,679)
2002-2005 Grant Prosiect Ymddiriedolaeth Wellcome "Cynhyrchu a swyddogaeth celloedd T CD8+, CD57+ a achosir gan haint HCMV" a ddyfarnwyd i E Wang (unig ddeiliad) (£167,415)
1995-1998 Cymrodoriaeth Goffa Beit "Mecanweithiau moleciwlaidd datblygu thymocyte" a ddyfarnwyd i E Wang (unig ddeiliad) (~£135,000)
CYFEIRNODAU
1. Wang EC et al, Clin Exp Immunol 94, 297 (1993); 2color. Wang EC et al, J Immunol 155, 5046 (1995); 3. Chong LK et al, Eur J Immunol 38, 995 (2008); 4. Tomasec P et al, Gwyddoniaeth 287, 1031 (2000); 5. Wang EC et al, PNAS USA 99, 7570 (2002); 6color. Ewyllysiau MR et al, J Immunol 175, 7457 (2005); 7. Ymgyrch Wang EC et al, PNAS UDA 115, 4998 (2018); 8color. Tomasec P, Wang EC et al, Nature Immunol 6, 181 (2005); 9color. Stanton RJ et al, Microbe Gwesteiwr Cell 16, 201 (2014); 10color. Prod'homme V et al, J Immunol 188, 2794 (2012); 11color. Fielding et al, PLoS Pathog 10, e1004058 (2014); 12. Fielding CA et al, Elife 6, e22206 (2017); 13. Rubina A et al, PNAS UDA 120, e2303155120 (2023); 14. Vlachava V et al, PNAS UDA 120, e2309077120 (2023); 15color. Wilkinson GW et al, Med Microbiol Immunol 204, 273 (2015); 16color. Patel M et al, Front Immunol 9, 2214 (2018) 17. Wang EC et al, Mol Cell Biol 21, 3451 (2001); 18. Bull MJ et al, J Exp Med 205, 2457 (2008); 19. Taraban VY et al, Mucosal Immunol 4, 186 (2011); 20. Twohig JP et al, FASEB J 26, 3675 (2012); 21. Meylan F et al, Imiwnedd 29, 79 (2008); 22. Malhotra N et al, Sci Immunol 3, eaa02892 (2018); 23. Collins FL et al, BMC Musculoskel Dis 20, 326 (2019).
Addysgu
Rwy'n darparu darlithoedd, tiwtorialau a phrosiectau ymchwil mewn Imiwnoleg a Firoleg i ystod o gyrsiau a ddarperir gan Brifysgol Caerdydd. Ar hyn o bryd, mae'r rhan fwyaf o'r rhain ar gyfer myfyrwyr meddygol (2il a 3edd flwyddyn), ond hefyd i'r cwrs Ffarmacoleg Feddygol. Rwyf hefyd yn addysgu ar yr MSc newydd mewn Imiwnoleg Glinigol Gymhwysol ac Arbrofol.
Bywgraffiad
PROFIAD GWAITH
Ebrill 2009 ymlaen Yr Is-adran Heintiau ac Imiwnedd, Ysgol Feddygaeth, Prifysgol Caerdydd
Athro: Awst 2021 ymlaen
Darllenydd: Awst 2009 i Gorff 2021
Uwch Ddarlithydd: Ebrill 2009 i Gorff 2009
Awst 2005 – Ebrill 2009 Ysgol Feddygaeth, Prifysgol Caerdydd
Uwch Ddarlithydd
Ionawr 2000 – Gorff 2005 Adran Heintiau ac Imiwnedd, Y Drindod Dewi Sant, Caerdydd
Uwch Ddarlithydd: Awst 2004 i Gorff 2005
Darlithydd: Ionawr 2000 i Gorff 2004
Hydref 1995 – Rhagfyr 1999 Cronfa Ymchwil Canser yr Ymerodrol, Llundain
Cymrawd Ymchwil Coffa Beit
Medi 1993 - Medi 1995 Adran Feddygaeth, Y Drindod Dewi Sant, Caerdydd
RA Ôl-ddoethurol
Hydref 1992 - Ionawr 1993 Adran Biocemeg Feddygol, Y Drindod Dewi Sant, Caerdydd
Cyn-PhD RA
Hydref 1989 - Awst 1993 Adran Feddygaeth, Prifysgol Caergrawnt (PhD)
PhD mewn Imiwnoleg
Anrhydeddau a dyfarniadau
2008 Gwobr Poster Diwydiant MRC, Arddangosfa Brechlynnau ac Imiwnotherapi IIB
2003 Grant Sefydlu Gyrfa MRC
1995 Cymrodoriaeth Goffa Beit ar gyfer Ymchwil Feddygol
Gwobr Cyflwyno Llafar 1992 , 7fed Cyfarfod Ymchwil Ôl-raddedig Blynyddol, Y Drindod Dewi Sant, Caerdydd
1989 Gwobr Goffa Dr. G. Fulton Roberts ar gyfer Imiwnoleg, Caergrawnt
Contact Details
Themâu ymchwil
Arbenigeddau
- Imiwnoleg cellog
- Firoleg