![Eddie Wang](https://profiles-cardiff.imgix.net/attachments/2634?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
I am a Professor of Viral Immunology within the 'Viral Immunology' Research Group (VIRG) of the Division of Infection & Immunity, School of Medicine, College of Biomedical & Life Sciences. My research covers the biology and cellular immunology relating to Human Cytomegalovirus (HCMV) and the biological function of Death Receptor 3, a member of the TNFR superfamily involved in control of inflammatory and autoimmune disease. More details of the HCMV work can be seen at the VIRG webpage (https://www.cardiff.ac.uk/research/explore/research-units/viral-immunology-research-group).
Further details of publications can be found on Researchgate (https://www.researchgate.net/profile/Eddie_Wang) and Google Scholar (https://scholar.google.co.uk/citations?hl=en&user=DgvpthYAAAAJ)
Professional Membership
- British Society of Immunology
- Microbiology Society
University Committees
- Human Tissue Officer for the Henry Wellcome Building, Division of Infection & Immunity
- Member of the Cardiff University HTA Research Governance Committee
- Panel Chair for PhD appraisals within the Division of Infection & Immunity
- Member of the Systems Immunity University Research Institute (SIURI)
- Grant panel member Cardiff University/Wellcome Trust ISSF scheme
- Immune Evasion theme Cardiff joint lead for the UK Coronavirus Immunology Consortium (UK-CIC)
- GW4-PhD scheme Infection, Immunity & Repair theme shortlisting/interview panel 2020/21
Publication
2024
- Litvin, U., Wang, E. C., Stanton, R. J., Fielding, C. A. and Hughes, J. 2024. Evolution of the cytomegalovirus RL11 gene family in old world monkeys and great apes. Virus Evolution 10(1), article number: veae066. (10.1093/ve/veae066)
- Kite, J., Hill, M., Preston, N., Rubina, A., Kollnberger, S., Wang, E. C. Y. and Elliott, G. 2024. Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function. Journal of General Virology 105(3) (10.1099/jgv.0.001969)
2023
- Vlachava, V. et al. 2023. HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation. Proceedings of the National Academy of Sciences 120(49), article number: e2309077120. (10.1073/pnas.2309077120)
- Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Luo, S., Liman, N., Li, C., Crossman, A., Wang, E. C. Y., Meylan, F. and Park, J. 2023. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. Cellular and Molecular Life Sciences 80(3), pp. 1-12., article number: 76. (10.1007/s00018-023-04726-7)
2022
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
- Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
- Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
- Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)
2021
- Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
- Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
2020
- Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
- Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
- Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)
2019
- Collins, F. L., Stone, M. D., Turton, J., McCabe, L. R., Wang, E. C. and Williams, A. S. 2019. Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels. BMC Musculoskeletal Disorders 20(1), article number: 326. (10.1186/s12891-019-2704-z)
- Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)
2018
- Boelen, L. et al. 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3(29), article number: eaao2892. (10.1126/sciimmunol.aao2892)
- Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
- Malhotra, N. et al. 2018. RORα-expressing T regulatory cells restrain allergic skin inflammation. Science Immunology 3(21), article number: eaao6923. (10.1126/sciimmunol.aao6923)
2017
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Collins, F. L. et al. 2017. CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone 97, pp. 94-104. (10.1016/j.bone.2017.01.002)
2016
- Williams, A., Wang, E. C. Y., Thurner, L. and Liu, C. 2016. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis & Rheumatology 68(12), pp. 2845-2856. (10.1002/art.39816)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021)
- Jia, L., Bamias, G., Burkly, L. C., Wang, E. C. Y., Gruszka, D., Pizarro, T. T. and Cominelli, F. 2016. A novel role for TL1A/DR3 in protection against intestinal injury and infection. Journal of Immunology 197(1), pp. 377-386. (10.4049/jimmunol.1502466)
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
2015
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Collins, F. L., Williams, J., Bloom, A. C., Stone, M. D., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2015. Death Receptor 3 (TNFRSF25) Increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice. Journal of Immunology Research 2015, pp. -., article number: 901679. (10.1155/2015/901679)
2014
- Wang, E. C. Y. et al. 2014. Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis and Rheumatology 66(10), pp. 2762-2772. (10.1002/art.38770)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
2013
- Pembroke, T., Christian, A., Jones, E., Hills, R. K., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a (10.1136/gutjnl-2013-304472)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
2012
- Collins, F., Stone, M. D., Goodfellow, R. M., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2012. TNF-like protein 1A/death receptor 3 pathway regulates osteoclastogenesis and is associated with erosive disease in rheumatoid arthritis. Arthritis and Rheumatism 64(10), pp. S768-S768.
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26(9), pp. 2146-2148. (10.1038/leu.2012.75)
- Wang, E. C. Y. 2012. On death receptor 3 and its ligands... Immunology 137(1), pp. 114-116. (10.1111/j.1365-2567.2012.03606.x)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42(9), pp. 2383-2394. (10.1002/eji.201142072)
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26(9), pp. 2148-2151. (10.1038/leu.2012.77)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26(8), pp. 3575-3586. (10.1096/fj.11-200618)
- Pembroke, T., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61(S2), pp. A144-A145. (10.1136/gutjnl-2012-302514b.174)
- Collins, F., Stone, M., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and tl1a: A regulatory pathway of bone turnover and target for osteoporosis therapy? [Abstract]. Osteoporosis International 23, pp. S528-S528.
- Calder, C. J. and Wang, E. C. Y. 2012. An essential role for death receptor 3 in experimental autoimmune uveoretinitis [Letter]. Ocular Immunology and Inflammation 20(3), pp. 212-214. (10.3109/09273948.2012.658135)
- Collins, F., Stone, M. D., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and Tl1a: A driving force in osteoclast differentiation and potential target for rheumatoid arthritis therapy [Abstract]. Rheumatology 51(s3), pp. 140-140. (10.1093/rheumatology/kes108)
- Al-Lamki, R. S., Lu, W., Finlay, S., Twohig, J. P., Wang, E. C. Y., Tolkovsky, A. M. and Bradley, J. R. 2012. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. American Journal of Pathology 180(4), pp. 1454-1464. (10.1016/j.ajpath.2012.01.003)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
2011
- Wang, E. C. Y. et al. 2011. Control of early cartilage destruction in inflammatory arthritis by death receptor 3 [Abstract]. Immunology 135(s1), pp. 153-153. (10.1111/j.1365-2567.2011.03534.x)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135(S1), pp. 178. (10.1111/j.1365-2567.2011.03534.x)
- Stacey, M. A., Marsden, M., Wang, E. C. Y., Wilkinson, G. W. G. and Humphreys, I. R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187(6), pp. 2944-2952. (10.4049/jimmunol.1101021)
- Coles, S., Wang, E. C. Y., Man, S. T., Hills, R. K., Burnett, A. K., Tonks, A. and Darley, R. L. 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25(5), pp. 792-799. (10.1038/leu.2011.1)
- Jones, G. W. et al. 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25(1), pp. 409-419. (10.1096/fj.10-166843)
- Wang, E. C. Y. 2011. CD4+ T cells, human cytomegalovirus and end-stage renal disease. Nephrology Dialysis Transplantation 26(5), pp. 1467-1470. (10.1093/ndt/gfr167)
2010
- Jones, G. W. et al. 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131(s1), pp. 102-102. (10.1111/j.1365-2567.2010.03390.x)
- Williams, A. S., Collins, F., Newton, Z., Goodfellow, R. M., Rajak, R., Calder, C. J. and Wang, E. C. Y. 2010. Death Receptor 3 orchestrates erosive pathology in inflammatory arthritis [Poster Abstract]. Immunology 131(s1), pp. 53-53. (10.1111/j.1365-2567.2010.03390.x)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116(21), pp. 218-218.
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
- Taraban, V. et al. 2010. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology 4(2), pp. 186-196. (10.1038/mi.2010.70)
2009
- Williams, A. S. et al. 2009. A functional role for death receptor-3 in arthritis [Abstract]. Cytokine 48(1-2), pp. 134-134. (10.1016/j.cyto.2009.07.568)
- Twohig, J. P. et al. 2009. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology 46(10), pp. 2002-2013. (10.1016/j.molimm.2009.03.007)
- Williams, A. S. et al. 2009. Functional role of dr3 in inflammatory arthritis: A novel target for therapy? [Abstract]. Rheumatology 48(s1), pp. I8-I8. (10.1093/rheumatology/kep704)
- Newton, Z., Bull, M., Wang, E. C. Y. and Williams, A. S. 2009. The role of dr3/tl1a in cartilage depletion caused by inflammatory arthritis [Abstract]. Rhuematology 48(s1), pp. I30-I30. (10.1093/rheumatology/kep713)
2008
- Jones, G. W. et al. 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125(s1), pp. 62-62. (10.1111/j.1365-2567.2008.02974.x)
- Williams, A. S. et al. 2008. The role of death receptor 3 in inflammatory arthritis [Abstract]. Immunology 125, pp. 34-34. (10.1111/j.1365-2567.2008.02974.x)
- Bull, M. J. et al. 2008. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. Journal of Experimental Medicine 205(11), pp. 2457-2464. (10.1084/jem.20072378)
- Meylan, F. et al. 2008. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1), pp. 79-89. (10.1016/j.immuni.2008.04.021)
- Al-Lamki, R. S. et al. 2008. TL1A both promotes and protects from renal inflammation and injury. Journal of the American Society of Nephrology 19(5), pp. 953-960. (10.1681/ASN.2007060706)
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
- Chong, L. K., Aicheler, R., Llewellyn-Lacey, S., Tomasec, P., Brennan, P. and Wang, E. C. Y. 2008. Proliferation and interleukin 5 production by CD8hiCD57+ T cells. European Journal of Immunology 38(4), pp. 995-1000. (10.1002/eji.200737687)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
2007
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Jones, G. W. et al. 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39(1), pp. 18-19.
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
2006
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. The Journal of Immunology 176(5), pp. 2915-2923. (10.4049/jimmunol.176.5.2915)
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Journal of immunology 176(5), pp. 2915-2923.
2005
- Griffin, C., Wang, E. C. Y., McSharry, B. P., Rickards, C. R., Browne, H., Wilkinson, G. W. G. and Tomasec, P. 2005. Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18. Journal of General Virology 86(11), pp. 2999-3008. (10.1099/vir.0.81126-0)
- Siebert, S., Amos, N., Fielding, C. A., Wang, E. C. Y., Aksentijevich, I., Williams, B. D. and Brennan, P. 2005. Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Arthritis & Rheumatism 52(4), pp. 1287-1282. (10.1002/art.20955)
- Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)
- Vedhara, K. and Wang, E. C. Y. 2005. Assessment of the immune system in human psychoneuroimmunology. In: Vedhara, K. and Irwin, M. R. eds. Human Psychneuroimmunology. Oxford: Oxford University Press, pp. 53-80.
2002
- Wang, E. C. Y. et al. 2002. UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proceedings of the National Academy of Sciences 99(11), pp. 7570-7575. (10.1073/pnas.112680099)
2001
- Wang, E. C. Y., Thern, A., Denzel, A., Kitson, J., Farrow, S. N. and Owen, M. J. 2001. DR3 regulates negative selection during thymocyte development. Molecular and cellular biology 21(10), pp. 3451-61. (10.1128/MCB.21.10.3451-3461.2001)
- Wang, E. C. Y., Kitson, J., Thern, A., Williamson, J., Farrow, S. N. and Owen, M. J. 2001. Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 53(1), pp. 59-63. (10.1007/s002510000290)
- Lawson, T. et al. 2001. Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR. International Immunology 13(11), pp. 1383-1390. (10.1093/intimm/13.11.1383)
1998
- Wang, E. C. Y. 1998. Sorting of human peripheral blood T-cell subsets using immunomagnetic beads. In: Pound, J. D. ed. Immunochemical Protocols., Vol. 80. Methods in Molecular Biology Vol. 2. Humana Press, pp. 365-376., (10.1007/978-1-59259-257-9_37)
1992
- Wang, E. C. Y., Borysiewicz, L. K. and Weetman, A. P. 1992. Cell sorting using immunomagnetic beads. In: Manson, M. M. ed. Immunochemical Protocols. Methods in Molecular Biology Vol. 10. Totowa, NJ: Humana Press, pp. 347-358.
Articles
- Litvin, U., Wang, E. C., Stanton, R. J., Fielding, C. A. and Hughes, J. 2024. Evolution of the cytomegalovirus RL11 gene family in old world monkeys and great apes. Virus Evolution 10(1), article number: veae066. (10.1093/ve/veae066)
- Kite, J., Hill, M., Preston, N., Rubina, A., Kollnberger, S., Wang, E. C. Y. and Elliott, G. 2024. Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function. Journal of General Virology 105(3) (10.1099/jgv.0.001969)
- Vlachava, V. et al. 2023. HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation. Proceedings of the National Academy of Sciences 120(49), article number: e2309077120. (10.1073/pnas.2309077120)
- Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Luo, S., Liman, N., Li, C., Crossman, A., Wang, E. C. Y., Meylan, F. and Park, J. 2023. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. Cellular and Molecular Life Sciences 80(3), pp. 1-12., article number: 76. (10.1007/s00018-023-04726-7)
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
- Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
- Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
- Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)
- Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
- Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
- Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
- Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
- Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)
- Collins, F. L., Stone, M. D., Turton, J., McCabe, L. R., Wang, E. C. and Williams, A. S. 2019. Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels. BMC Musculoskeletal Disorders 20(1), article number: 326. (10.1186/s12891-019-2704-z)
- Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)
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- Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
- Malhotra, N. et al. 2018. RORα-expressing T regulatory cells restrain allergic skin inflammation. Science Immunology 3(21), article number: eaao6923. (10.1126/sciimmunol.aao6923)
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Collins, F. L. et al. 2017. CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone 97, pp. 94-104. (10.1016/j.bone.2017.01.002)
- Williams, A., Wang, E. C. Y., Thurner, L. and Liu, C. 2016. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis & Rheumatology 68(12), pp. 2845-2856. (10.1002/art.39816)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021)
- Jia, L., Bamias, G., Burkly, L. C., Wang, E. C. Y., Gruszka, D., Pizarro, T. T. and Cominelli, F. 2016. A novel role for TL1A/DR3 in protection against intestinal injury and infection. Journal of Immunology 197(1), pp. 377-386. (10.4049/jimmunol.1502466)
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Collins, F. L., Williams, J., Bloom, A. C., Stone, M. D., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2015. Death Receptor 3 (TNFRSF25) Increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice. Journal of Immunology Research 2015, pp. -., article number: 901679. (10.1155/2015/901679)
- Wang, E. C. Y. et al. 2014. Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis and Rheumatology 66(10), pp. 2762-2772. (10.1002/art.38770)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
- Pembroke, T., Christian, A., Jones, E., Hills, R. K., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a (10.1136/gutjnl-2013-304472)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
- Collins, F., Stone, M. D., Goodfellow, R. M., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2012. TNF-like protein 1A/death receptor 3 pathway regulates osteoclastogenesis and is associated with erosive disease in rheumatoid arthritis. Arthritis and Rheumatism 64(10), pp. S768-S768.
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26(9), pp. 2146-2148. (10.1038/leu.2012.75)
- Wang, E. C. Y. 2012. On death receptor 3 and its ligands... Immunology 137(1), pp. 114-116. (10.1111/j.1365-2567.2012.03606.x)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42(9), pp. 2383-2394. (10.1002/eji.201142072)
- Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26(9), pp. 2148-2151. (10.1038/leu.2012.77)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26(8), pp. 3575-3586. (10.1096/fj.11-200618)
- Pembroke, T., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61(S2), pp. A144-A145. (10.1136/gutjnl-2012-302514b.174)
- Collins, F., Stone, M., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and tl1a: A regulatory pathway of bone turnover and target for osteoporosis therapy? [Abstract]. Osteoporosis International 23, pp. S528-S528.
- Calder, C. J. and Wang, E. C. Y. 2012. An essential role for death receptor 3 in experimental autoimmune uveoretinitis [Letter]. Ocular Immunology and Inflammation 20(3), pp. 212-214. (10.3109/09273948.2012.658135)
- Collins, F., Stone, M. D., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and Tl1a: A driving force in osteoclast differentiation and potential target for rheumatoid arthritis therapy [Abstract]. Rheumatology 51(s3), pp. 140-140. (10.1093/rheumatology/kes108)
- Al-Lamki, R. S., Lu, W., Finlay, S., Twohig, J. P., Wang, E. C. Y., Tolkovsky, A. M. and Bradley, J. R. 2012. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. American Journal of Pathology 180(4), pp. 1454-1464. (10.1016/j.ajpath.2012.01.003)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
- Wang, E. C. Y. et al. 2011. Control of early cartilage destruction in inflammatory arthritis by death receptor 3 [Abstract]. Immunology 135(s1), pp. 153-153. (10.1111/j.1365-2567.2011.03534.x)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135(S1), pp. 178. (10.1111/j.1365-2567.2011.03534.x)
- Stacey, M. A., Marsden, M., Wang, E. C. Y., Wilkinson, G. W. G. and Humphreys, I. R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187(6), pp. 2944-2952. (10.4049/jimmunol.1101021)
- Coles, S., Wang, E. C. Y., Man, S. T., Hills, R. K., Burnett, A. K., Tonks, A. and Darley, R. L. 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25(5), pp. 792-799. (10.1038/leu.2011.1)
- Jones, G. W. et al. 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25(1), pp. 409-419. (10.1096/fj.10-166843)
- Wang, E. C. Y. 2011. CD4+ T cells, human cytomegalovirus and end-stage renal disease. Nephrology Dialysis Transplantation 26(5), pp. 1467-1470. (10.1093/ndt/gfr167)
- Jones, G. W. et al. 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131(s1), pp. 102-102. (10.1111/j.1365-2567.2010.03390.x)
- Williams, A. S., Collins, F., Newton, Z., Goodfellow, R. M., Rajak, R., Calder, C. J. and Wang, E. C. Y. 2010. Death Receptor 3 orchestrates erosive pathology in inflammatory arthritis [Poster Abstract]. Immunology 131(s1), pp. 53-53. (10.1111/j.1365-2567.2010.03390.x)
- Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116(21), pp. 218-218.
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
- Taraban, V. et al. 2010. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology 4(2), pp. 186-196. (10.1038/mi.2010.70)
- Williams, A. S. et al. 2009. A functional role for death receptor-3 in arthritis [Abstract]. Cytokine 48(1-2), pp. 134-134. (10.1016/j.cyto.2009.07.568)
- Twohig, J. P. et al. 2009. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology 46(10), pp. 2002-2013. (10.1016/j.molimm.2009.03.007)
- Williams, A. S. et al. 2009. Functional role of dr3 in inflammatory arthritis: A novel target for therapy? [Abstract]. Rheumatology 48(s1), pp. I8-I8. (10.1093/rheumatology/kep704)
- Newton, Z., Bull, M., Wang, E. C. Y. and Williams, A. S. 2009. The role of dr3/tl1a in cartilage depletion caused by inflammatory arthritis [Abstract]. Rhuematology 48(s1), pp. I30-I30. (10.1093/rheumatology/kep713)
- Jones, G. W. et al. 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125(s1), pp. 62-62. (10.1111/j.1365-2567.2008.02974.x)
- Williams, A. S. et al. 2008. The role of death receptor 3 in inflammatory arthritis [Abstract]. Immunology 125, pp. 34-34. (10.1111/j.1365-2567.2008.02974.x)
- Bull, M. J. et al. 2008. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. Journal of Experimental Medicine 205(11), pp. 2457-2464. (10.1084/jem.20072378)
- Meylan, F. et al. 2008. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1), pp. 79-89. (10.1016/j.immuni.2008.04.021)
- Al-Lamki, R. S. et al. 2008. TL1A both promotes and protects from renal inflammation and injury. Journal of the American Society of Nephrology 19(5), pp. 953-960. (10.1681/ASN.2007060706)
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
- Chong, L. K., Aicheler, R., Llewellyn-Lacey, S., Tomasec, P., Brennan, P. and Wang, E. C. Y. 2008. Proliferation and interleukin 5 production by CD8hiCD57+ T cells. European Journal of Immunology 38(4), pp. 995-1000. (10.1002/eji.200737687)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Jones, G. W. et al. 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39(1), pp. 18-19.
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. The Journal of Immunology 176(5), pp. 2915-2923. (10.4049/jimmunol.176.5.2915)
- Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Journal of immunology 176(5), pp. 2915-2923.
- Griffin, C., Wang, E. C. Y., McSharry, B. P., Rickards, C. R., Browne, H., Wilkinson, G. W. G. and Tomasec, P. 2005. Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18. Journal of General Virology 86(11), pp. 2999-3008. (10.1099/vir.0.81126-0)
- Siebert, S., Amos, N., Fielding, C. A., Wang, E. C. Y., Aksentijevich, I., Williams, B. D. and Brennan, P. 2005. Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Arthritis & Rheumatism 52(4), pp. 1287-1282. (10.1002/art.20955)
- Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)
- Wang, E. C. Y. et al. 2002. UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proceedings of the National Academy of Sciences 99(11), pp. 7570-7575. (10.1073/pnas.112680099)
- Wang, E. C. Y., Thern, A., Denzel, A., Kitson, J., Farrow, S. N. and Owen, M. J. 2001. DR3 regulates negative selection during thymocyte development. Molecular and cellular biology 21(10), pp. 3451-61. (10.1128/MCB.21.10.3451-3461.2001)
- Wang, E. C. Y., Kitson, J., Thern, A., Williamson, J., Farrow, S. N. and Owen, M. J. 2001. Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 53(1), pp. 59-63. (10.1007/s002510000290)
- Lawson, T. et al. 2001. Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR. International Immunology 13(11), pp. 1383-1390. (10.1093/intimm/13.11.1383)
Book sections
- Vedhara, K. and Wang, E. C. Y. 2005. Assessment of the immune system in human psychoneuroimmunology. In: Vedhara, K. and Irwin, M. R. eds. Human Psychneuroimmunology. Oxford: Oxford University Press, pp. 53-80.
- Wang, E. C. Y. 1998. Sorting of human peripheral blood T-cell subsets using immunomagnetic beads. In: Pound, J. D. ed. Immunochemical Protocols., Vol. 80. Methods in Molecular Biology Vol. 2. Humana Press, pp. 365-376., (10.1007/978-1-59259-257-9_37)
- Wang, E. C. Y., Borysiewicz, L. K. and Weetman, A. P. 1992. Cell sorting using immunomagnetic beads. In: Manson, M. M. ed. Immunochemical Protocols. Methods in Molecular Biology Vol. 10. Totowa, NJ: Humana Press, pp. 347-358.
Research
RESEARCH THEMES
I have had a long-standing interest in human cytomegalovirus (HCMV), a herpesvirus that is the primary infectious cause of congenital abnormalities and causes life-threatening disease in immunosuppressed transplant recipients and AIDS patients. HCMV infects for life and imprints on the immune system; I originally reported on the oligoclonal nature of CD8+CD57+ T cell expansions associated with HCMV infection over 25 years ago (1-3). I have made a substantial contribution to our understanding of HCMV immune evasion holding multiple MRC research and Wellcome Trust programme grants to study this since. Peter Tomasec, Gavin Wilkinson and myself were the first to fully define a viral NK evasion function (HCMV UL40) (4, 5). In exploring differences between laboratory and clinical HCMV strains with Richard Stanton, we further identified UL135, UL141, UL142 (with Mark Wills, Cambridge) and UL148 as novel NK evasion functions (6-9). In re-evaluating the HLA-I homologue UL18, we demonstrated that UL18 provided for LIR1-dependent NK inhibition (10) and identified US18 and US20 as the dominant HCMV immunoevasins responsible for suppressing the NK cell activating ligands MICA and B7-H6 (11, 12). Most recent research has demonstrated ADAM17 targeting by UL148 and UL148D profoundly alters the surface proteome of infected cells and indirectly inhibits NK cells (13), while the soluble UL4 protein blocks TRAIL-mediated induction of cell death and NK activation (14). This represents ~half of all known HCMV-encoded NK inhibitors (15, 16). My track record in immune evasion led to inclusion as the Cardiff joint lead for the Immune Evasion theme for the UK Coronavirus Immunology Consortium (UK-CIC) studying the immunopathology of SARS-CoV-2.
I have also made a substantial contribution to the field of Death Receptor 3 (DR3) research. DR3 is a member of the Tumour Necrosis Factor Receptor Superfamily involved in immune regulation. I generated the only known DR3ko mouse (17), establishing DR3's essential function in inflammatory/autoimmune diseases ranging from inflammatory arthritis (18) to inflammatory bowel disease (19) and antiviral immunity (20) through controlling T-cell (21, 22) and myeloid function (18, 23).
CURRENT FUNDING (major grants only)
2023-2030 Wellcome Trust Discovery Award "Exploiting novel antiviral immune responses" awarded to R Stanton (PI), E Wang (£1,976,186)
2023-2027 GW4-PhD Studenstship "Generating killer cells for immunotherapy against cancer and pathogens" awarded to E Wang (PI), M Heinrich-Sevcenco, R Stanton, L Wooldridge (Bristol) (£114,536)
2022-2025 KRUK Project Grant "Identifying risk factors in kidney transplant patients for disease caused by human cytomegalovirus infection" awarded to E Wang (PI), R Stanton, S Griffin (£209,986)
2021-2026 5-year technician funded through collaboration on a Wellcome Trust SIA awarded to Ben Willcox (University of Birmingham) "Exploring innate-like and adaptive gamma delta T cell paradigms in health and disease" (~£2m, £379,510 of which to Cardiff)
2020-2024 MRC Project Grant "Characterisation of a novel class of natural killer cell immunoevasin" awarded to E Wang (PI), R Stanton, D Price, S Kollnberger (£819,703)
HISTORICAL FUNDING (major grants only)
2021-2023 NIHR Project Grant "The immunologic and virologic determinants of long COVID" awarded to D Price (PI), H Davies, I Humphreys, P Morgan, R Stanton, E Wang (£744,457)
2019-2023 MRC Project Grant "The role of antibody in enabling cell-mediated control of HCMV infection" awarded to R Stanton (PI), E Wang (£762,492)
2017-2023 Wellcome Trust Collaboration Grant "Analysis of cytomegalovirus pathogenesis in a human challenge system" awarded to P Griffiths (University College London). Wang named collaborator (~£1.7m, £329,728 of which to Cardiff for PDRA)
2020-2021 MRC Research Grant "A UK underpinning platform to study immunology and immunopathology of COVID-19: The UK Coronavirus Immunology Consortium" awarded to P Moss (University of Birmingham) and 73 other Co-Investigators across UK including E Wang (~£8m, £300,000 of which to Cardiff for 3 posts in different labs)
2017-2021 MRC Project Grant "Systematic characterisation of the HCMV pathogenicity domain spontaneously lost from commonly used passaged strains" awarded to E Wang (PI - sole holder), G Wilkinson (retired), P Tomasec (deceased) (£956,196)
2010-2018 Wellcome Trust Programme Grant "Modulation of host immunity by human cytomegalovirus" awarded to G Wilkinson (PI), E Wang, P Tomasec (£1,062,032)
2014-2018 MRC Project Grant "A systematic investigation into human cytomegalovirus gene function" awarded to G Wilkinson (PI), E Wang, P Tomasec (£679,426)
2010-2013 MRC Project Grant "An analysis of wild type human cytomegalovirus" awarded to G Wilkinson (PI), E Wang, P Tomasec (£901,468)
2009-2013 MRC Project Grant "Investigating the modulation of immunity to persistent viral infection by the death receptor 3/TNF-like 1A pathway" awarded to E Wang (PI), I Humphreys (£467,078)
2007-2010 MRC Project Grant "Modulation of natural killer cells by human cytomegalovirus" awarded to G Wilkinson (PI), E Wang, P Tomasec (£668,526)
2006-2009 MRC Collaboration Grant "Cellular and viral immunology resource at the Wales College of Medicine, Cardiff University" awarded to E Wang (PI), A Gallimore (£188,888)
2004-2009 MRC Career Establishment Grant "The role of death receptor 3 in peripheral CD8+ T cell function" awarded to E Wang (sole holder) (£643,596)
2004-2009 Wellcome Trust Programme Grant "Immune modulation by human cytomegalovirus" awarded to G Wilkinson (PI), E Wang, P Tomasec (£789,117)
2004-2007 Wellcome Trust Project Grant "Immune evasion by Epstein Barr virus" awarded to M Rowe (PI), E Wang (£304,679)
2002-2005 Wellcome Trust Project Grant "Generation and function of CD8+, CD57+ T cells induced by HCMV infection" awarded to E Wang (sole holder) (£167,415)
1995-1998 Beit Memorial Fellowship "Molecular mechanisms of thymocyte development" awarded to E Wang (sole holder) (~£135,000)
REFERENCES
1. Wang EC et al, Clin Exp Immunol 94, 297 (1993); 2. Wang EC et al, J Immunol 155, 5046 (1995); 3. Chong LK et al, Eur J Immunol 38, 995 (2008); 4. Tomasec P et al, Science 287, 1031 (2000); 5. Wang EC et al, PNAS USA 99, 7570 (2002); 6. Wills MR et al, J Immunol 175, 7457 (2005); 7. Wang EC et al, PNAS USA 115, 4998 (2018); 8. Tomasec P, Wang EC et al, Nature Immunol 6, 181 (2005); 9. Stanton RJ et al, Cell Host Microbe 16, 201 (2014); 10. Prod'homme V et al, J Immunol 188, 2794 (2012); 11. Fielding et al, PLoS Pathog 10, e1004058 (2014); 12. Fielding CA et al, Elife 6, e22206 (2017); 13. Rubina A et al, PNAS USA 120, e2303155120 (2023); 14. Vlachava V et al, PNAS USA 120, e2309077120 (2023); 15. Wilkinson GW et al, Med Microbiol Immunol 204, 273 (2015); 16. Patel M et al, Front Immunol 9, 2214 (2018) 17. Wang EC et al, Mol Cell Biol 21, 3451 (2001); 18. Bull MJ et al, J Exp Med 205, 2457 (2008); 19. Taraban VY et al, Mucosal Immunol 4, 186 (2011); 20. Twohig JP et al, FASEB J 26, 3675 (2012); 21. Meylan F et al, Immunity 29, 79 (2008); 22. Malhotra N et al, Sci Immunol 3, eaa02892 (2018); 23. Collins FL et al, BMC Musculoskel Dis 20, 326 (2019).
Teaching
I provide lectures, tutorials and research projects in Immunology and Virology to a range of courses supplied by Cardiff University. Currently, the majority of these are to medical students (2nd and 3rd year), but also to the Medical Pharmacology course. I also teach on the new MSc in Applied & Experimental Clinical Immunology.
Biography
WORK EXPERIENCE
Apr 2009 onwards Division of Infection & Immunity, School of Medicine, Cardiff University
Professor: Aug 2021 onwards
Reader: Aug 2009 to Jul 2021
Senior Lecturer: Apr 2009 to Jul 2009
Aug 2005 – Apr 2009 School of Medicine, Cardiff University
Senior Lecturer
Jan 2000 – Jul 2005 Section of Infection and Immunity, UWCM, Cardiff
Senior Lecturer: Aug 2004 to Jul 2005
Lecturer: Jan 2000 to Jul 2004
Oct 1995 – Dec 1999 Imperial Cancer Research Fund, London
Beit Memorial Research Fellow
Sept 1993 - Sept 1995 Department of Medicine, UWCM, Cardiff
Post-Doctoral RA
Oct 1992 - Jan 1993 Department of Medical Biochemistry, UWCM, Cardiff
Pre-PhD RA
Oct 1989 - Aug 1993 Department of Medicine, University of Cambridge (PhD)
PhD in Immunology
Honours and awards
2008 MRC Industry Poster Award, IIB Vaccines and Immunotherapy Showcase
2003 MRC Career Establishment Grant
1995 Beit Memorial Fellowship for Medical Research
1992 Oral Presentation Prize, 7th Annual Postgraduate Research Meeting, UWCM, Cardiff
1989 Dr. G. Fulton Roberts Memorial Prize for Immunology, Cambridge
Contact Details
Research themes
Specialisms
- Cellular immunology
- Virology