Yr Athro David Williams
Arweinydd Thema y Gwyddorau Biofeddygol a Llafar, Athro Microbioleg Llafar, Ysgol Deintyddiaeth
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Athro Microbioleg Lafar yn yr Ysgol Deintyddiaeth gyda ffocws ymchwil mewn bioffilmiau microbaidd.
Cyhoeddiad
2023
- Board-Davies, E. L., Rhys-Williams, W., Hynes, D., Love, W. G. and Williams, D. W. 2023. Antimicrobial effects of XF drugs against Candida albicans and its biofilms. Frontiers in Fungal Biology 4, article number: 1225647. (10.3389/ffunb.2023.1225647)
- Twigg, J. A., Smith, A., Haury, C., Wilson, M., Lees, J., Waters, M. and Williams, D. W. 2023. Compositional shifts within the denture-associated bacteriome in pneumonia – an analytical cross-sectional study. Journal of Medical Microbiology 72(6) (10.1099/jmm.0.001702)
- Martorano-Fernandes, L., Brito, A., Araújo, E., Almeida, L., Wei, X., Williams, D. and Cavalcanti, Y. 2023. Epithelial responses and Candida albicans pathogenicity are enhanced in the presence of oral streptococci.. Brazilian Dental Journal 34(3), pp. 73-81. (10.1590/0103-6440202305420)
- Nassar, R., Nassar, M., Senok, A. and Williams, D. 2023. Phytic acid demonstrates rapid antibiofilm activity and inhibits biofilm formation when used as a surface conditioning agent. Microbiology Spectrum 11(3), article number: e00267-23. (10.1128/spectrum.00267-23)
- Serpi, M. et al. 2023. Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites. Journal of Molecular Structure 1278, article number: 134977. (10.1016/j.molstruc.2023.134977)
- Serrano-Diaz, P. et al. 2023. Geranium leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on Candida albicans. Green Processing and Synthesis 12(1), article number: 202281. (10.1515/gps-2022-8105)
2022
- Board-Davies, E. L., Rhys-Williams, W., Hynes, D., Williams, D., Farnell, D. J. and Love, W. 2022. Antibacterial and antibiofilm potency of XF drugs, impact of photodynamic activation and synergy with antibiotics.. Frontiers in Cellular and Infection Microbiology 12, article number: 904465. (10.3389/fcimb.2022.904465)
2021
- Nassar, R. et al. 2021. Antimicrobial activity of phytic acid: an emerging agent in dentistry. Frontiers in Cellular and Infection Microbiology 11, article number: 753649. (10.3389/fcimb.2021.753649)
- Williams, A., Rogers, H., Williams, D., Wei, X., Farnell, D., Wozniak, S. and Jones, A. 2021. Higher number of EBI3 cells in mucosal chronic hyperplastic candidiasis may serve to regulate IL-17 producing cells. Journal of Fungi 7(7), article number: 533. (10.3390/jof7070533)
- Vanhatalo, A. et al. 2021. Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions. Redox Biology 41, article number: 101933. (10.1016/j.redox.2021.101933)
- Nassar, M. et al. 2021. Phytic acid: properties and potential applications in dentistry. Frontiers in Materials 8, article number: 638909. (10.3389/fmats.2021.638909)
- Nassar, R., Hachim, M. Y., Nassar, M., Kaklamanos, E. G., Jamal, M., Williams, D. and Senok, A. 2021. Microbial metabolic genes crucial for S. aureus biofilms: an insight from re-analysis of publicly available microarray datasets. Frontiers in Microbiology 11, article number: 607002. (10.3389/fmicb.2020.607002)
2020
- Henriques, M. and Williams, D. 2020. Pathogenesis and virulence of Candida albicans and Candida glabrata. Pathogens 9(9), article number: 752. (10.3390/pathogens9090752)
- Serra, E. et al. 2020. Methylcellulose hydrogel with melissa officinalis essential oil as a potential treatment for oral candidiasis. Microorganisms 8(2), article number: 215. (10.3390/microorganisms8020215)
- Yee Lim, S. et al. 2020. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International Journal of Pharmaceutics 573, article number: 118860. (10.1016/j.ijpharm.2019.118860)
- Smith, A., Al Kutubi, S., Williams, D., Bradshaw, D., Rowe, W. and Milward, P. 2020. The effect of residual food stain on microbial colonisation of denture acrylics with the increase of Candida albicans. Dental Oral Biology and Craniofacial Research 3(2), pp. 2-5. (10.31487/j.DOBCR.2020.02.06)
2019
- Williams, A. et al. 2019. Immunohistochemical expression patterns of inflammatory cells involved in Chronic Hyperplastic Candidosis. Pathogens 8(4), article number: 232. (10.3390/pathogens8040232)
- Morse, D. J. et al. 2019. Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. Scientific Reports 9, article number: 10228. (10.1038/s41598-019-46494-0)
- Lins, R. X., Hirata, R., Wilson, M., Lewis, M. A. O., Fidel, R. A. S. and Williams, D. 2019. Comparison of genotypes, antimicrobial resistance and virulence profiles of oral and non oral Enterococcus faecalis from Brazil, Japan and the United Kingdom. Journal of dentistry 84, pp. 49-54. (10.1016/j.jdent.2019.03.002)
- Morse, D., Wilson, M., Wei, X. q., Bradshaw, D., Lewis, M. and Williams, D. 2019. Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria. Letters in Applied Microbiology 68(4), pp. 337-343. (10.1111/lam.13145)
2018
- Pinto, S. d. S. et al. 2018. Antimicrobial activity of per acetic acid for trans-operative disinfection of endodontic files. International Journal of Advanced Engineering Research and Science 5(11), pp. 132. (10.22161/ijaers.5.11.18)
- Vanhatalo, A. et al. 2018. Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Free Radical Biology and Medicine 124, pp. 21-30. (10.1016/j.freeradbiomed.2018.05.078)
- Morse, D., Wilson, M., Wei, X., Lewis, M. A. O., Bradshaw, D. J., Murdoch, C. and Williams, D. 2018. Denture-associated biofilm infection in 3-dimensional 1 oral mucosal tissue models. Journal of Medical Microbiology 67(3), pp. 364-375. (10.1099/jmm.0.000677)
- Serra, E., Hildalgo-Bastida, L. A., Verran, J., Williams, D. and Malic, S. 2018. Antifungal activity of commercial essential oils and biocides against Candida albicans. Pathogens 7(1), article number: 15. (10.3390/pathogens7010015)
2017
- Lewis, M. and Williams, D. 2017. Diagnosis and management of oral candidosis. British Dental Journal 223, pp. 675 -681. (10.1038/sj.bdj.2017.886)
- Marino, P. J., Wise, M. P., Smith, A., Marchesi, J. R., Riggio, M. P., Lewis, M. A. O. and Williams, D. W. 2017. Community analysis of dental plaque and endotracheal tube biofilms from mechanically ventilated patients. Journal of Critical Care 39, pp. 149-155. (10.1016/j.jcrc.2017.02.020)
- Mariyaselvam, M. Z., Marsh, L., Bamford, S., Smith, A., Wise, M. and Williams, D. 2017. Endotracheal tubes and fluid aspiration: An in vitro evaluation of new cuff technologies. BMC Anesthesiology 17, article number: 36. (10.1186/s12871-017-0328-0)
- Sands, K. M. et al. 2017. Respiratory pathogen colonisation of dental plaque, the lower airways and endotracheal tube biofilms during mechanical ventilation. Journal of Critical Care 37, pp. 30-37. (10.1016/j.jcrc.2016.07.019)
2016
- Marino, P. J. et al. 2016. Comparison of foam swabs and toothbrushes as oral hygiene interventions in mechanically ventilated patients: a randomised split mouth study. BMJ Open Respiratory Research 2016(3), article number: e000150. (10.1136/bmjresp-2016-000150)
- Cavalcanti, Y. W., Wilson, M., Lewis, M., Williams, D., Senna, P. M., Del-Bel-Cury, A. A. and Silva, W. J. d. 2016. Salivary pellicles equalise surfaces' charges and modulate the virulence of Candida albicans biofilm. Archives of Oral Biology 66, pp. 129-140. (10.1016/j.archoralbio.2016.02.016)
- Benjamin, T., Marsh, L. L., Jonathan, N. and Williams, D. 2016. A novel approach to antibiofilm susceptibility testing using a thermo-reversible matrix. Journal of Wound Care 25(2), pp. 62-67. (10.12968/jowc.2016.25.2.62)
- Sands, K. M. et al. 2016. Microbial profiling of dental plaque from mechanically ventilated patients. Journal of Medical Microbiology 65(2), pp. 147-159. (10.1099/jmm.0.000212)
- Cavalcanti, Y. W., Wilson, M., Lewis, M. A. O., Del-Bel-Cury, A. A., da Silva, W. J. and Williams, D. W. 2016. Modulation of Candida albicansvirulence by bacterial biofilms on titanium surfaces. Biofouling 32(2), pp. 123-134. (10.1080/08927014.2015.1125472)
- Dantas de Almeida, L. d. F., Felipe de Paula, J., Dantas de Almeida, R. V., Williams, D. W., Hebling, J. and Cavalcanti, Y. W. 2016. Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms. Acta Odontologica Scandinavica 74(5), pp. 393-398. (10.3109/00016357.2016.1166261)
2015
- Boros-Majewska, J., Turczyk, L., Wei, X., Milewski, S. and Williams, D. W. 2015. A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukemic cells infected with Candida albicans. Journal of Applied Microbiology 119(1), pp. 177-187. (10.1111/jam.12817)
- Cavalcanti, Y. W. et al. 2015. Virulence and pathogenicity of Candida albicans is enhanced in biofilms containing oral bacteria. Biofouling 31(1), pp. 27-38. (10.1080/08927014.2014.996143)
- Jordan, R. P. C., Malic, S., Waters, M. G. J., Stickler, D. J. and Williams, D. W. 2015. Development of an antimicrobial urinary catheter to inhibit urinary catheter encrustation. Microbiology Discovery 3(1), article number: 1. (10.7243/2052-6180-3-1)
- Xu, R., Sun, H., Williams, D. W., Jones, A. V., Al-Hussaini, A., Song, B. and Wei, X. 2015. IL-34 suppresses 'Candida albicans' induced TNFα production in M1 macrophages by downregulating expression of Dectin-1 and TLR2. Journal of Immunology Research 2015, article number: 328146. (10.1155/2015/328146)
- Mariyaselvam, M. Z., Wise, M. P. and Williams, D. W. 2015. Translating in vitro research: Improving endotracheal tube bench test methodology [Letter]. American Journal of Respiratory and Critical Care Medicine 192(5), pp. 642. (10.1164/rccm.201505-0956LE)
2014
- Alves, C. T., Silva, S., Pereira, L., Williams, D. W., Azeredo, J. and Henriques, M. 2014. Effect of progesterone on candida albicans vaginal pathogenicity. International Journal of Medical Microbiology 304(8), pp. 1011-1017. (10.1016/j.ijmm.2014.07.004)
- Alves, C. T., Wei, X., Silva, S., Azeredo, J., Henriques, M. and Williams, D. W. 2014. Candida albicans promotes invasion and colonisation of Candida glabrata in a reconstituted human vaginal epithelium. Journal of Infection 69(4), pp. 396-407. (10.1016/j.jinf.2014.06.002)
- Boros-Majewska, J. et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology 203(5), pp. 341-355. (10.1007/s00430-014-0343-4)
- Jordan, R. P. C., Williams, D. W., Moran, G. P., Coleman, D. C. and Sullivan, D. J. 2014. Comparative adherence of Candida albicans and Candida dubliniensis to human buccal epithelial cells and extracellular matrix proteins. Medical Mycology 52(3), pp. 254-263. (10.1093/mmy/myt032)
- Sands, K. M., Williams, D. W., Wilson, M. J., Lewis, M. A. O., Marsh, L. L. and Wise, M. P. 2014. Mechanisms of augmented growth of Pseudomonas aeruginosa mediated by Candida albicans [Letter]. Critical Care Medicine 42(3), pp. e256. (10.1097/CCM.0000000000000113)
- Malic, S., Jordan, R. P. C., Waters, M. G. J., Stickler, D. J. and Williams, D. W. 2014. Biocide activity against urinary catheter pathogens. Antimicrobial Agents and Chemotherapy 58(2), pp. 1192-1194. (10.1128/AAC.01106-13)
- Percival, S. L. et al. eds. 2014. Biofilms in infection prevention and control: A healthcare handbook. London: Elsevier.
2013
- Rogers, H. et al. 2013. Immune response and candidal colonisation in denture associated stomatitis. Journal of Clinical & Cellular Immunology 4(6), article number: 178. (10.4172/2155-9899.1000178)
- Sands, K. M., Williams, D. W., Wilson, M. J., Lewis, M. A. O. and Wise, M. P. 2013. The dynamics of polymicrobial biofilms [Letter]. American Journal of Respiratory and Critical Care Medicine 188(10), pp. 1266. (10.1164/rccm.201305-0916LE)
- Williams, D. W., Jordan, R. P. C., Wei, X., Alves, C. T., Wise, M. P., Wilson, M. J. and Lewis, M. A. O. 2013. Interactions of Candida albicans with host epithelial surfaces. Journal of Oral Microbiology 5, article number: 22434. (10.3402/jom.v5i0.22434)
- Ximenes Lins, R., de Oliveira Andrade, A., Hirata Junior, R., Wilson, M. J., Lewis, M. A., Williams, D. W. and Fidel, R. A. S. 2013. Antimicrobial resistance and virulence traits of Enterococcus faecalis from primary endodontic infections. Journal of Dentistry 41(9), pp. 779-786. (10.1016/j.jdent.2013.07.004)
- Daw, A. E. et al. 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28(1), pp. 144-160. (10.1177/0885328212441495)
- Zheng, X. F. et al. 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8(5), article number: e63967. (10.1371/journal.pone.0063967)
- Rogers, H., Williams, D. W., Feng, G. J., Lewis, M. A. O. and Wei, X. 2013. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clinical and Developmental Immunology 2013, article number: 320168. (10.1155/2013/320168)
- Almalioti, F. et al. 2013. Convenient syntheses of cyanuric chloride-derived NHC ligands, their Ag(i) and Au(i) complexes and antimicrobial activity. Dalton Transactions 42(34), pp. 12370-12380. (10.1039/c3dt51400e)
- Silva, S. et al. 2013. The effect of silver nanoparticles and nystatin on mixed biofilms of Candida glabrata and Candida albicans on acrylic. Medical Mycology 51(2), pp. 178-184. (10.3109/13693786.2012.700492)
- Malic, S., Emanuel, C., Lewis, M. A. O. and Williams, D. W. 2013. Antimicrobial activity of novel mouthrinses against planktonic cells and biofilms of pathogenic microorganisms. Microbiology Discovery 1, article number: 11. (10.7243/2052-6180-1-11)
- Percival, S. L., Yates, M. V., Williams, D. W., Chalmers, R. M. and Gray, N. F. 2013. Microbiology of waterborne diseases: microbiological aspects and risks. London: Elsevier.
2012
- Hooper, S. J., Percival, S. L., Hill, K. E., Thomas, D. W., Hayes, A. J. and Williams, D. W. 2012. The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal 9(6), pp. 633-642. (10.1111/j.1742-481X.2012.00927.x)
- Percival, S. L., Hill, K. E., Williams, D. W., Hooper, S. J., Thomas, D. W. and Costerton, J. W. 2012. A review of the scientific evidence for biofilms in wounds. Wound Repair and Regeneration 20(5), pp. 647-657. (10.1111/j.1524-475X.2012.00836.x)
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Landrygan-Bakri, J., Wilson, M. J., Williams, D. W., Lewis, M. A. O. and Waddington, R. J. 2012. Real-time monitoring of adherence of Streptococcus anginosus group bacteria to extracellular matrix decorin and biglycan proteoglycans in biofilm formation. Research in Microbiology 163(6-7), pp. 436-447. (10.1016/j.resmic.2012.07.006)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Mahmoud, H. M., Williams, D. W., Hannigan, A. and Lynch, C. D. 2012. Influence of extracellular matrix proteins in enhancing bacterial adhesion to titanium surfaces. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B(5), pp. 1319-1327. (10.1002/jbm.b.32698)
- Malic, S., Waters, M. G. J., Basil, L., Stickler, D. J. and Williams, D. W. 2012. Development of an 'early warning' sensor for encrustation of urinary catheters following Proteus infection. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B(1), pp. 133-137. (10.1002/jbm.b.31930)
- Percival, S. L., Emanuel, C., Cutting, K. F. and Williams, D. W. 2012. Microbiology of the skin and the role of biofilms in infection. International Wound Journal 9(1), pp. 14-32. (10.1111/j.1742-481X.2011.00836.x)
- Hooper, S. J., Williams, D. W., Thomas, D. W., Hill, K. E. and Percival, S. L. 2012. An in vitro comparison of two silver- containing antimicrobial wound dressings. Ostomy Wound Management 58(1), pp. 16-22.
2011
- Marino, P., Williams, D. W., Lewis, M. A. O., Wise, M., Frost, P. J. and Thomas, J. 2011. Effects of oral microbes on biofilm formation by respiratory pathogens. Presented at: 2011 IADR/AADR/CADR General Session, San Diego, CA, USA, 19 March 2011.
- Silva, S., Hooper, S. J., Henriques, M., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa. Clinical Microbiology and Infection 17(2), pp. 264-272. (10.1111/j.1469-0691.2010.03248.x)
- Percival, S. L., Hill, K. E., Malic, S., Thomas, D. W. and Williams, D. W. 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19(1), pp. 1-9. (10.1111/j.1524-475X.2010.00651.x)
- Wei, X., Rogers, H., Lewis, M. A. O. and Williams, D. W. 2011. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Clinical & Developmental Immunology, article number: 697340. (10.1155/2011/697340)
- Williams, D. W. and Lewis, M. A. O. 2011. Pathogenesis and treatment of oral candidosis. Journal of Oral Microbiology 3 (10.3402/jom.v3i0.5771)
- Williams, D. W., Chamary, N., Lewis, M. A. O., Milward, P. J. and McAndrew, R. 2011. Microbial contamination of removable prosthodontic appliances from laboratories and impact of clinical storage. British Dental Journal 211(4), pp. 163-166. (10.1038/sj.bdj.2011.675)
- Williams, D. W., Kuriyama, T., Silva, S., Malic, S. and Lewis, M. A. O. 2011. Candida biofilms and oral candidosis: Treatment and prevention. Periodontology 2000 55(1), pp. 250-265. (10.1111/j.1600-0757.2009.00338.x)
- Cairns, S. et al. 2011. Molecular analysis of microbial communities in endotracheal tube biofilms. PLoS ONE 6(3) (10.1371/journal.pone.0014759)
- Hooper, S. J., Lewis, M. A. O., Wilson, M. J. and Williams, D. W. 2011. Antimicrobial activity of Citrox (R) bioflavonoid preparations against oral microorganisms. British Dental Journal 210(1) (10.1038/sj.bdj.2010.1224)
- Silva, S., Henriques, M. C., Hayes, A. J., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Journal of Oral Pathology and Medicine 40(5), pp. 421-427. (10.1111/j.1600-0714.2010.00981.x)
- Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2011. Adherence and biofilm formation of non-Candida albicans Candida species. Trends in Microbiology 19(5), pp. 241-247. (10.1016/j.tim.2011.02.003)
- Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2011. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiology Reviews 36(2), pp. 288-305. (10.1111/j.1574-6976.2011.00278.x)
- Malic, S., Hill, K. E., Playle, R. A., Thomas, D. W. and Williams, D. W. 2011. In vitro interaction of chronic wound bacteria in biofilms. Journal of Wound Care 20(12), pp. 569-577.
- Williams, D. W., Marino, P. J., Thomas, J. G. and Lewis, M. A. O. 2011. The role of human oral microflora in ventilator- associated pneumonia. Annual Clinical Journal of Dental Health 1, pp. 16-21.
- Percival, S. L., Malic, S., Cruz, H. and Williams, D. W. 2011. Introduction to biofilms. In: Percival, S. L., Kottenbelt, D. C. and Cochrane, C. A. eds. Biofilms and Veterinary Medicine. Springer Series on Biofilms Vol. 6. London: Springer, pp. 41-68., (10.1007/978-3-642-21289-5_2)
2010
- Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2010. Silicone colonization by non-Candida albicans Candida species in the presence of urine. Journal of Medical Microbiology 59(7), pp. 747-754. (10.1099/jmm.0.017517-0)
- Hallier, C., Williams, D. W., Potts, A. J. C. and Lewis, M. A. O. 2010. A pilot study of bioaerosol reduction using an air cleaning system during dental procedures. British Dental Journal 209(8), article number: E14. (10.1038/sj.bdj.2010.975)
- Hill, K. E., Malic, S., McKee, R., Rennison, T., Harding, K. G., Williams, D. W. and Thomas, D. W. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65(6), pp. 1195-1206. (10.1093/jac/dkq105)
- Wise, M. P., Williams, D. W., Lewis, M. A. O. and Frost, P. J. 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key?. Critical care (London, England) 14(4), article number: 181. (10.1186/cc9084)
- Percival, S. L., Thomas, J. G. and Williams, D. W. 2010. Biofilms and bacterial imbalances in chronic wounds: Anti-Koch. International Wound Journal 7(3), pp. 169-175. (10.1111/j.1742-481X.2010.00668.x)
- Silva, S., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2010. In vitro biofilm activity of non-Candida albicans Candida species. Current Microbiology 61(6), pp. 534-540. (10.1007/s00284-010-9649-7)
- Tambo, T., Kuriyama, T., Karasawa, T., Yamamoto, E. and Williams, D. W. 2010. Genetic heterogeneity of prevotella strains involved in dentoalveolar abscess. Archives of Clinical Microbiology 1(4), article number: 4.
- Kuriyama, T., Lewis, M. A. O. and Williams, D. W. 2010. Infections of the oral and maxillofacial region. In: Andersson, L., Kahnberg, K. and Pogrel, M. A. eds. Oral and Maxillofacial Surgery. Chichester: Wiley, pp. 467-582.
2009
- Silva, S., Henriques, M., Oliveira, R., Azeredo, J., Malic, S., Hooper, S. J. and Williams, D. W. 2009. Characterization of Candida parapsilosis infection of an in vitro reconstituted human oral epithelium. European Journal of Oral Sciences 117(6), pp. 669-675. (10.1111/j.1600-0722.2009.00677.x)
- Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)
- Silva, S., Henriques, M., Martins, A., Oliveira, R., Williams, D. W. and Azeredo, J. 2009. Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition. Medical Mycology 47(7), pp. 681-689. (10.3109/13693780802549594)
- Marsh, P. D., Martin, M. V., Williams, D. W. and Lewis, M. A. O. 2009. Oral microbiology. 5th ed.. London: Churchill Livingstone.
2008
- Wise, M. P., Williams, D. W., Lewis, M. A. O., Thomas, J. G. and Frost, P. J. 2008. Impact of poor dental health on pneumonia. European Respiratory Journal 32(4), pp. 1123-1124. (10.1183/09031936.00096808)
- Cairns, S. et al. 2008. Characterisation of biofilms within medical devices [Abstract]. Wound Repair and Regeneration 16(6), pp. A70. (10.1111/j.1524-475X.2008.00424.x)
- Shimizu, C., Kuriyama, T., Williams, D. W., Karasawa, T., Inoue, K., Nakagawa, K. and Yamamoto, E. 2008. Association of oral yeast carriage with specific host factors and altered mouth sensation. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 105(4), pp. 445-451. (10.1016/j.tripleo.2007.11.030)
- Williams, D. W. 2008. Characterisation of biofilms on epithelial surfaces by confocal microscopy. Wound Repair and Regeneration 16(6), pp. A69-A69.
- Wise, M. P., Cole, J. M., Williams, D. W., Lewis, M. A. O. and Frost, P. J. 2008. Efficacy of oral chlorhexidine in critical care [Letter]. Critical Care 12(3) (10.1186/cc6886)
2007
- Malic, S., Hill, K. E., Ralphs, J. R., Hayes, A. J., Thomas, D. W., Potts, A. J. C. and Williams, D. W. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22(3), pp. 188-194. (10.1111/j.1399-302X.2007.00344.x)
- Noake, T., Kuriyama, T., White, P. L., Potts, A. J. C., Lewis, M. A. O., Williams, D. W. and Barnes, R. A. 2007. Antifungal susceptibility of Candida species using the Clinical and Laboratory Standards Institute disk diffusion and broth microdilution methods. Journal of Chemotherapy 19(3), pp. 283-287. (10.1179/joc.2007.19.3.283)
- Kuriyama, T. et al. 2007. Antimicrobial susceptibility of 800 anaerobic isolates from patients with dentoalveolar infection to 13 oral antibiotics. Oral Microbiology and Immunology 22(4), pp. 285-288. (10.1111/j.1399-302X.2007.00365.x)
2006
- Pier-Francesco, A., Adams, R., Waters, M. G. J. and Williams, D. W. 2006. Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an in vitro study. Clinical Oral Implants Research 17(6), pp. 633-637. (10.1111/j.1600-0501.2006.01274.x)
- Williams, D. W., Iwahara, K., Kuriyama, T. and Shimura, S. 2006. Detection of cfxA and cfxA2, the β-lactamase genes of Prevotella spp., in clinical samples from dentoalveolar infection by real-time PCR. Journal of Clinical Microbiology 44(1), pp. 172-176. (10.1128/JCM.44.1.172-176.2006)
- Kuriyama, T., Karasawa, T., Williams, D. W., Nakagawa, K. and Yamamoto, E. 2006. An increased prevalence of β-lactamase-positive isolates in Japanese patients with dentoalveolar infection [Letter]. Journal of Antimicrobial Chemotherapy 58(3), pp. 708-709. (10.1093/jac/dkl287)
- Yanagisawa, M., Kuriyama, T., Williams, D. W., Nakagawa, K. and Karasawa, T. 2006. Proteinase Activity of Prevotella Species Associated with Oral Purulent Infection. Current Microbiology 52(5), pp. 375-378. (10.1007/s00284-005-0261-1)
2005
- Kuriyama, T., Absi, E. G., Williams, D. W. and Lewis, M. A. O. 2005. An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance. British Dental Journal 198(12), pp. 759-763. (10.1038/sj.bdj.4812415)
- Price, C. L. et al. 2005. Reduced adherence of Candida to silane-treated silicone rubber. Journal of Biomedical Materials Research Part B: Applied Biomaterials 74B(1), pp. 481-487. (10.1002/jbm.b.30226)
- Kuriyama, T., Williams, D. W., Bagg, J., Coulter, W. A., Ready, D. and Lewis, M. A. O. 2005. In vitro susceptibility of oral Candida to seven antifungal agents. Oral Microbiology and Immunology 20(6), pp. 349-353. (10.1111/j.1399-302X.2005.00236.x)
2004
- Bartie, K. L., Williams, D. W., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2004. Differential invasion of Candida albicans isolates in an in vitro model of oral candidosis. Oral Microbiology And Immunolology 19(5), pp. 293-296. (10.1111/j.1399-302X.2004.00155.x)
- White, P. L., Williams, D. W., Kuriyama, T., Samad, S. A., Lewis, M. A. O. and Barnes, R. A. 2004. Detection of Candida in concentrated oral rinse cultures by real-time PCR. Journal of clinical microbiology 42(5), pp. 2101-2107. (10.1128/JCM.42.5.2101-2107.2004)
- Williams, D. W. et al. 2004. Sex determination by PCR analysis of DNA extracted from incinerated, deciduous teeth. Science & Justice 44(2), pp. 89-94. (10.1016/S1355-0306(04)71694-9)
- Cross, L., Williams, D. W., Sweeney, C., Jackson, M., Lewis, M. A. O. and Bagg, J. 2004. Evaluation of the recurrence of denture stomatitis and Candida colonization in a small group of patients who received itraconazole. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 97(3), pp. 351-358. (10.1016/j.tripleo.2003.10.006)
2003
- Kuriyama, T., Williams, D. W., Patel, M., Lewis, M. A. O., Jenkins, L. E., Hill, D. W. and Hosein, I. K. 2003. Molecular characterisation of clinical and environmental isolates of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis from a teaching hospital in Wales. Journal of Medical Microbiology 52(9), pp. 821-827. (10.1099/jmm.0.05123-0)
- Kuriyama, T., Williams, D. W. and Lewis, M. A. O. 2003. In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Microbiology and Immunology 18(6), pp. 405-407. (10.1046/j.0902-0055.2002.00100.x)
2002
- Price, C., Waters, M. G. J., Williams, D. W., Lewis, M. A. O. and Stickler, D. J. 2002. Surface modification of an experimental silicone rubber aimed at reducing initial candidal adhesion. Journal of Biomedical Materials Research 63(2), pp. 122-128. (10.1002/jbm.10094)
2001
- Bartie, K. L., Williams, D. W., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2001. PCR fingerprinting of Candida albicans associated with chronic hyperplastic candidosis and other oral conditions. Journal of clinical microbiology 39(11), pp. 4066-4075. (10.1128/JCM.39.11.4066-4075.2001)
- Wilson, M., Williams, D. W., Forbes, M., Finlay, I. G. and Lewis, M. A. O. 2001. A molecular epidemiological study of sequential oral isolates of Candida albicans from terminally ill patients. Journal Of Oral Pathology & Medicine 30(4), pp. 206-212. (10.1034/j.1600-0714.2001.300403.x)
- Williams, D. W., Bartie, K. L., Potts, A. J. C., Wilson, M., Fardy, M. J. and Lewis, M. A. O. 2001. Strain persistence of invasive Candida albicans in chronic hyperplastic candidosis that underwent malignant change. Gerodontology 18(2), pp. 73-78. (10.1111/j.1741-2358.2001.00073.x)
- Williams, D. W., Coulter, W. A., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2001. Identification of Candida dubliniensis, based on ribosomal DNA sequence analysis. British Journal of Biomedical Science 58(1), pp. 11-16.
2000
- Bartie, K. L., Wilson, M., Williams, D. W. and Lewis, M. A. O. 2000. Macrorestriction fingerprinting of "Streptococcus milleri" group bacteria by pulsed-field gel electrophoresis. Journal of Clinical Microbiology 38(6), pp. 2141-2149.
- Williams, D. W. and Lewis, M. A. O. 2000. Oral microbiology: isolation and identification of candida from the oral cavity. Oral Diseases 6(1), pp. 3-11. (10.1111/j.1601-0825.2000.tb00314.x)
- Williams, D. W., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2000. Phenotypic characterisation of Candida albicans isolated from chronic hyperplastic candidosis. Journal of Medical Microbiology 49(2), pp. 199-202.
1998
- Williams, D. W., Waters, M. G. J., Potts, A. J. C. and Lewis, M. A. O. 1998. A novel technique for assessment of adherence of Candida albicans to solid surfaces. Journal of Clinical Pathology 51(5), pp. 390-391. (10.1136/jcp.51.5.390)
- Williams, D. W., Jones, H. S., Allison, R. T., Potts, A. J. C. and Lewis, M. A. O. 1998. Immunocytochemical detection of Candida albicans in formalin fixed, paraffin embedded material. Journal of Clinical Pathology 51(11), pp. 857-859. (10.1136/jcp.51.11.857)
1997
- Waters, M. G. J., Williams, D. W., Jagger, R. G. and Lewis, M. A. O. 1997. Adherence of Candida albicans to experimental denture soft lining materials. Journal of Prosthetic Dentistry 77(3), pp. 306-312. (10.1016/S0022-3913(97)70188-4)
- Williams, D. W., Potts, A. J. C., Wilson, M., Matthews, J. B. and Lewis, M. A. O. 1997. Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa. Journal of Oral Pathology & Medicine 26(2), pp. 83-89. (10.1111/j.1600-0714.1997.tb00026.x)
1996
- Williams, D. W., Wilson, M., Lewis, M. A. O. and Potts, A. J. C. 1996. Identification of Candida species in formalin fixed, paraffin wax embedded oral mucosa by sequencing of ribosomal DNA. Clinical Molecular Pathology 49, pp. M23-M28. (10.1136/mp.49.1.M23)
1995
- Williams, D. W., Wilson, M., Lewis, M. A. O. and Potts, A. J. C. 1995. Identification of Candida species by PCR and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal DNA. Journal of Clinical Microbiology 33(9), pp. 2476-2479.
1994
- Nicholas, R. O., Williams, D. W. and Hunter, P. A. 1994. Investigation of the value of β-glucan-specific fluorochromes for predicting the β-glucan content of the cell walls of zoopathogenic fungi. Mycological Research 98(6), pp. 694-698. (10.1016/S0953-7562(09)80419-X)
- Patel, P. D. and Williams, D. W. 1994. Evaluation of commercial kits and instruments for the detection of foodborne pathogens and toxins. In: Patel, P. ed. Rapid Analysis Techniques in Food Microbiology. London: Blackie Academic & Professional, pp. 61-103.
1993
- Patel, P. D., Williams, D. W. and Haines, S. D. 1993. Rapid separation and detection of foodborne yeasts and moulds by means of lectins. In: Kroll, R. G., Gilmour, A. and Sussman, M. eds. New Techniques in Food and Beverage Microbiology. Technical series (Society for Applied Bacteriology) Vol. 31. Oxford: Blackwell Scientific Publications, pp. 31-42.
Adrannau llyfrau
- Percival, S. L., Malic, S., Cruz, H. and Williams, D. W. 2011. Introduction to biofilms. In: Percival, S. L., Kottenbelt, D. C. and Cochrane, C. A. eds. Biofilms and Veterinary Medicine. Springer Series on Biofilms Vol. 6. London: Springer, pp. 41-68., (10.1007/978-3-642-21289-5_2)
- Kuriyama, T., Lewis, M. A. O. and Williams, D. W. 2010. Infections of the oral and maxillofacial region. In: Andersson, L., Kahnberg, K. and Pogrel, M. A. eds. Oral and Maxillofacial Surgery. Chichester: Wiley, pp. 467-582.
- Patel, P. D. and Williams, D. W. 1994. Evaluation of commercial kits and instruments for the detection of foodborne pathogens and toxins. In: Patel, P. ed. Rapid Analysis Techniques in Food Microbiology. London: Blackie Academic & Professional, pp. 61-103.
- Patel, P. D., Williams, D. W. and Haines, S. D. 1993. Rapid separation and detection of foodborne yeasts and moulds by means of lectins. In: Kroll, R. G., Gilmour, A. and Sussman, M. eds. New Techniques in Food and Beverage Microbiology. Technical series (Society for Applied Bacteriology) Vol. 31. Oxford: Blackwell Scientific Publications, pp. 31-42.
Cynadleddau
- Marino, P., Williams, D. W., Lewis, M. A. O., Wise, M., Frost, P. J. and Thomas, J. 2011. Effects of oral microbes on biofilm formation by respiratory pathogens. Presented at: 2011 IADR/AADR/CADR General Session, San Diego, CA, USA, 19 March 2011.
Erthyglau
- Board-Davies, E. L., Rhys-Williams, W., Hynes, D., Love, W. G. and Williams, D. W. 2023. Antimicrobial effects of XF drugs against Candida albicans and its biofilms. Frontiers in Fungal Biology 4, article number: 1225647. (10.3389/ffunb.2023.1225647)
- Twigg, J. A., Smith, A., Haury, C., Wilson, M., Lees, J., Waters, M. and Williams, D. W. 2023. Compositional shifts within the denture-associated bacteriome in pneumonia – an analytical cross-sectional study. Journal of Medical Microbiology 72(6) (10.1099/jmm.0.001702)
- Martorano-Fernandes, L., Brito, A., Araújo, E., Almeida, L., Wei, X., Williams, D. and Cavalcanti, Y. 2023. Epithelial responses and Candida albicans pathogenicity are enhanced in the presence of oral streptococci.. Brazilian Dental Journal 34(3), pp. 73-81. (10.1590/0103-6440202305420)
- Nassar, R., Nassar, M., Senok, A. and Williams, D. 2023. Phytic acid demonstrates rapid antibiofilm activity and inhibits biofilm formation when used as a surface conditioning agent. Microbiology Spectrum 11(3), article number: e00267-23. (10.1128/spectrum.00267-23)
- Serpi, M. et al. 2023. Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites. Journal of Molecular Structure 1278, article number: 134977. (10.1016/j.molstruc.2023.134977)
- Serrano-Diaz, P. et al. 2023. Geranium leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on Candida albicans. Green Processing and Synthesis 12(1), article number: 202281. (10.1515/gps-2022-8105)
- Board-Davies, E. L., Rhys-Williams, W., Hynes, D., Williams, D., Farnell, D. J. and Love, W. 2022. Antibacterial and antibiofilm potency of XF drugs, impact of photodynamic activation and synergy with antibiotics.. Frontiers in Cellular and Infection Microbiology 12, article number: 904465. (10.3389/fcimb.2022.904465)
- Nassar, R. et al. 2021. Antimicrobial activity of phytic acid: an emerging agent in dentistry. Frontiers in Cellular and Infection Microbiology 11, article number: 753649. (10.3389/fcimb.2021.753649)
- Williams, A., Rogers, H., Williams, D., Wei, X., Farnell, D., Wozniak, S. and Jones, A. 2021. Higher number of EBI3 cells in mucosal chronic hyperplastic candidiasis may serve to regulate IL-17 producing cells. Journal of Fungi 7(7), article number: 533. (10.3390/jof7070533)
- Vanhatalo, A. et al. 2021. Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions. Redox Biology 41, article number: 101933. (10.1016/j.redox.2021.101933)
- Nassar, M. et al. 2021. Phytic acid: properties and potential applications in dentistry. Frontiers in Materials 8, article number: 638909. (10.3389/fmats.2021.638909)
- Nassar, R., Hachim, M. Y., Nassar, M., Kaklamanos, E. G., Jamal, M., Williams, D. and Senok, A. 2021. Microbial metabolic genes crucial for S. aureus biofilms: an insight from re-analysis of publicly available microarray datasets. Frontiers in Microbiology 11, article number: 607002. (10.3389/fmicb.2020.607002)
- Henriques, M. and Williams, D. 2020. Pathogenesis and virulence of Candida albicans and Candida glabrata. Pathogens 9(9), article number: 752. (10.3390/pathogens9090752)
- Serra, E. et al. 2020. Methylcellulose hydrogel with melissa officinalis essential oil as a potential treatment for oral candidiasis. Microorganisms 8(2), article number: 215. (10.3390/microorganisms8020215)
- Yee Lim, S. et al. 2020. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International Journal of Pharmaceutics 573, article number: 118860. (10.1016/j.ijpharm.2019.118860)
- Smith, A., Al Kutubi, S., Williams, D., Bradshaw, D., Rowe, W. and Milward, P. 2020. The effect of residual food stain on microbial colonisation of denture acrylics with the increase of Candida albicans. Dental Oral Biology and Craniofacial Research 3(2), pp. 2-5. (10.31487/j.DOBCR.2020.02.06)
- Williams, A. et al. 2019. Immunohistochemical expression patterns of inflammatory cells involved in Chronic Hyperplastic Candidosis. Pathogens 8(4), article number: 232. (10.3390/pathogens8040232)
- Morse, D. J. et al. 2019. Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. Scientific Reports 9, article number: 10228. (10.1038/s41598-019-46494-0)
- Lins, R. X., Hirata, R., Wilson, M., Lewis, M. A. O., Fidel, R. A. S. and Williams, D. 2019. Comparison of genotypes, antimicrobial resistance and virulence profiles of oral and non oral Enterococcus faecalis from Brazil, Japan and the United Kingdom. Journal of dentistry 84, pp. 49-54. (10.1016/j.jdent.2019.03.002)
- Morse, D., Wilson, M., Wei, X. q., Bradshaw, D., Lewis, M. and Williams, D. 2019. Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria. Letters in Applied Microbiology 68(4), pp. 337-343. (10.1111/lam.13145)
- Pinto, S. d. S. et al. 2018. Antimicrobial activity of per acetic acid for trans-operative disinfection of endodontic files. International Journal of Advanced Engineering Research and Science 5(11), pp. 132. (10.22161/ijaers.5.11.18)
- Vanhatalo, A. et al. 2018. Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Free Radical Biology and Medicine 124, pp. 21-30. (10.1016/j.freeradbiomed.2018.05.078)
- Morse, D., Wilson, M., Wei, X., Lewis, M. A. O., Bradshaw, D. J., Murdoch, C. and Williams, D. 2018. Denture-associated biofilm infection in 3-dimensional 1 oral mucosal tissue models. Journal of Medical Microbiology 67(3), pp. 364-375. (10.1099/jmm.0.000677)
- Serra, E., Hildalgo-Bastida, L. A., Verran, J., Williams, D. and Malic, S. 2018. Antifungal activity of commercial essential oils and biocides against Candida albicans. Pathogens 7(1), article number: 15. (10.3390/pathogens7010015)
- Lewis, M. and Williams, D. 2017. Diagnosis and management of oral candidosis. British Dental Journal 223, pp. 675 -681. (10.1038/sj.bdj.2017.886)
- Marino, P. J., Wise, M. P., Smith, A., Marchesi, J. R., Riggio, M. P., Lewis, M. A. O. and Williams, D. W. 2017. Community analysis of dental plaque and endotracheal tube biofilms from mechanically ventilated patients. Journal of Critical Care 39, pp. 149-155. (10.1016/j.jcrc.2017.02.020)
- Mariyaselvam, M. Z., Marsh, L., Bamford, S., Smith, A., Wise, M. and Williams, D. 2017. Endotracheal tubes and fluid aspiration: An in vitro evaluation of new cuff technologies. BMC Anesthesiology 17, article number: 36. (10.1186/s12871-017-0328-0)
- Sands, K. M. et al. 2017. Respiratory pathogen colonisation of dental plaque, the lower airways and endotracheal tube biofilms during mechanical ventilation. Journal of Critical Care 37, pp. 30-37. (10.1016/j.jcrc.2016.07.019)
- Marino, P. J. et al. 2016. Comparison of foam swabs and toothbrushes as oral hygiene interventions in mechanically ventilated patients: a randomised split mouth study. BMJ Open Respiratory Research 2016(3), article number: e000150. (10.1136/bmjresp-2016-000150)
- Cavalcanti, Y. W., Wilson, M., Lewis, M., Williams, D., Senna, P. M., Del-Bel-Cury, A. A. and Silva, W. J. d. 2016. Salivary pellicles equalise surfaces' charges and modulate the virulence of Candida albicans biofilm. Archives of Oral Biology 66, pp. 129-140. (10.1016/j.archoralbio.2016.02.016)
- Benjamin, T., Marsh, L. L., Jonathan, N. and Williams, D. 2016. A novel approach to antibiofilm susceptibility testing using a thermo-reversible matrix. Journal of Wound Care 25(2), pp. 62-67. (10.12968/jowc.2016.25.2.62)
- Sands, K. M. et al. 2016. Microbial profiling of dental plaque from mechanically ventilated patients. Journal of Medical Microbiology 65(2), pp. 147-159. (10.1099/jmm.0.000212)
- Cavalcanti, Y. W., Wilson, M., Lewis, M. A. O., Del-Bel-Cury, A. A., da Silva, W. J. and Williams, D. W. 2016. Modulation of Candida albicansvirulence by bacterial biofilms on titanium surfaces. Biofouling 32(2), pp. 123-134. (10.1080/08927014.2015.1125472)
- Dantas de Almeida, L. d. F., Felipe de Paula, J., Dantas de Almeida, R. V., Williams, D. W., Hebling, J. and Cavalcanti, Y. W. 2016. Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms. Acta Odontologica Scandinavica 74(5), pp. 393-398. (10.3109/00016357.2016.1166261)
- Boros-Majewska, J., Turczyk, L., Wei, X., Milewski, S. and Williams, D. W. 2015. A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukemic cells infected with Candida albicans. Journal of Applied Microbiology 119(1), pp. 177-187. (10.1111/jam.12817)
- Cavalcanti, Y. W. et al. 2015. Virulence and pathogenicity of Candida albicans is enhanced in biofilms containing oral bacteria. Biofouling 31(1), pp. 27-38. (10.1080/08927014.2014.996143)
- Jordan, R. P. C., Malic, S., Waters, M. G. J., Stickler, D. J. and Williams, D. W. 2015. Development of an antimicrobial urinary catheter to inhibit urinary catheter encrustation. Microbiology Discovery 3(1), article number: 1. (10.7243/2052-6180-3-1)
- Xu, R., Sun, H., Williams, D. W., Jones, A. V., Al-Hussaini, A., Song, B. and Wei, X. 2015. IL-34 suppresses 'Candida albicans' induced TNFα production in M1 macrophages by downregulating expression of Dectin-1 and TLR2. Journal of Immunology Research 2015, article number: 328146. (10.1155/2015/328146)
- Mariyaselvam, M. Z., Wise, M. P. and Williams, D. W. 2015. Translating in vitro research: Improving endotracheal tube bench test methodology [Letter]. American Journal of Respiratory and Critical Care Medicine 192(5), pp. 642. (10.1164/rccm.201505-0956LE)
- Alves, C. T., Silva, S., Pereira, L., Williams, D. W., Azeredo, J. and Henriques, M. 2014. Effect of progesterone on candida albicans vaginal pathogenicity. International Journal of Medical Microbiology 304(8), pp. 1011-1017. (10.1016/j.ijmm.2014.07.004)
- Alves, C. T., Wei, X., Silva, S., Azeredo, J., Henriques, M. and Williams, D. W. 2014. Candida albicans promotes invasion and colonisation of Candida glabrata in a reconstituted human vaginal epithelium. Journal of Infection 69(4), pp. 396-407. (10.1016/j.jinf.2014.06.002)
- Boros-Majewska, J. et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology 203(5), pp. 341-355. (10.1007/s00430-014-0343-4)
- Jordan, R. P. C., Williams, D. W., Moran, G. P., Coleman, D. C. and Sullivan, D. J. 2014. Comparative adherence of Candida albicans and Candida dubliniensis to human buccal epithelial cells and extracellular matrix proteins. Medical Mycology 52(3), pp. 254-263. (10.1093/mmy/myt032)
- Sands, K. M., Williams, D. W., Wilson, M. J., Lewis, M. A. O., Marsh, L. L. and Wise, M. P. 2014. Mechanisms of augmented growth of Pseudomonas aeruginosa mediated by Candida albicans [Letter]. Critical Care Medicine 42(3), pp. e256. (10.1097/CCM.0000000000000113)
- Malic, S., Jordan, R. P. C., Waters, M. G. J., Stickler, D. J. and Williams, D. W. 2014. Biocide activity against urinary catheter pathogens. Antimicrobial Agents and Chemotherapy 58(2), pp. 1192-1194. (10.1128/AAC.01106-13)
- Rogers, H. et al. 2013. Immune response and candidal colonisation in denture associated stomatitis. Journal of Clinical & Cellular Immunology 4(6), article number: 178. (10.4172/2155-9899.1000178)
- Sands, K. M., Williams, D. W., Wilson, M. J., Lewis, M. A. O. and Wise, M. P. 2013. The dynamics of polymicrobial biofilms [Letter]. American Journal of Respiratory and Critical Care Medicine 188(10), pp. 1266. (10.1164/rccm.201305-0916LE)
- Williams, D. W., Jordan, R. P. C., Wei, X., Alves, C. T., Wise, M. P., Wilson, M. J. and Lewis, M. A. O. 2013. Interactions of Candida albicans with host epithelial surfaces. Journal of Oral Microbiology 5, article number: 22434. (10.3402/jom.v5i0.22434)
- Ximenes Lins, R., de Oliveira Andrade, A., Hirata Junior, R., Wilson, M. J., Lewis, M. A., Williams, D. W. and Fidel, R. A. S. 2013. Antimicrobial resistance and virulence traits of Enterococcus faecalis from primary endodontic infections. Journal of Dentistry 41(9), pp. 779-786. (10.1016/j.jdent.2013.07.004)
- Daw, A. E. et al. 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28(1), pp. 144-160. (10.1177/0885328212441495)
- Zheng, X. F. et al. 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8(5), article number: e63967. (10.1371/journal.pone.0063967)
- Rogers, H., Williams, D. W., Feng, G. J., Lewis, M. A. O. and Wei, X. 2013. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clinical and Developmental Immunology 2013, article number: 320168. (10.1155/2013/320168)
- Almalioti, F. et al. 2013. Convenient syntheses of cyanuric chloride-derived NHC ligands, their Ag(i) and Au(i) complexes and antimicrobial activity. Dalton Transactions 42(34), pp. 12370-12380. (10.1039/c3dt51400e)
- Silva, S. et al. 2013. The effect of silver nanoparticles and nystatin on mixed biofilms of Candida glabrata and Candida albicans on acrylic. Medical Mycology 51(2), pp. 178-184. (10.3109/13693786.2012.700492)
- Malic, S., Emanuel, C., Lewis, M. A. O. and Williams, D. W. 2013. Antimicrobial activity of novel mouthrinses against planktonic cells and biofilms of pathogenic microorganisms. Microbiology Discovery 1, article number: 11. (10.7243/2052-6180-1-11)
- Hooper, S. J., Percival, S. L., Hill, K. E., Thomas, D. W., Hayes, A. J. and Williams, D. W. 2012. The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal 9(6), pp. 633-642. (10.1111/j.1742-481X.2012.00927.x)
- Percival, S. L., Hill, K. E., Williams, D. W., Hooper, S. J., Thomas, D. W. and Costerton, J. W. 2012. A review of the scientific evidence for biofilms in wounds. Wound Repair and Regeneration 20(5), pp. 647-657. (10.1111/j.1524-475X.2012.00836.x)
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Landrygan-Bakri, J., Wilson, M. J., Williams, D. W., Lewis, M. A. O. and Waddington, R. J. 2012. Real-time monitoring of adherence of Streptococcus anginosus group bacteria to extracellular matrix decorin and biglycan proteoglycans in biofilm formation. Research in Microbiology 163(6-7), pp. 436-447. (10.1016/j.resmic.2012.07.006)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Mahmoud, H. M., Williams, D. W., Hannigan, A. and Lynch, C. D. 2012. Influence of extracellular matrix proteins in enhancing bacterial adhesion to titanium surfaces. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B(5), pp. 1319-1327. (10.1002/jbm.b.32698)
- Malic, S., Waters, M. G. J., Basil, L., Stickler, D. J. and Williams, D. W. 2012. Development of an 'early warning' sensor for encrustation of urinary catheters following Proteus infection. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B(1), pp. 133-137. (10.1002/jbm.b.31930)
- Percival, S. L., Emanuel, C., Cutting, K. F. and Williams, D. W. 2012. Microbiology of the skin and the role of biofilms in infection. International Wound Journal 9(1), pp. 14-32. (10.1111/j.1742-481X.2011.00836.x)
- Hooper, S. J., Williams, D. W., Thomas, D. W., Hill, K. E. and Percival, S. L. 2012. An in vitro comparison of two silver- containing antimicrobial wound dressings. Ostomy Wound Management 58(1), pp. 16-22.
- Silva, S., Hooper, S. J., Henriques, M., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa. Clinical Microbiology and Infection 17(2), pp. 264-272. (10.1111/j.1469-0691.2010.03248.x)
- Percival, S. L., Hill, K. E., Malic, S., Thomas, D. W. and Williams, D. W. 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19(1), pp. 1-9. (10.1111/j.1524-475X.2010.00651.x)
- Wei, X., Rogers, H., Lewis, M. A. O. and Williams, D. W. 2011. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Clinical & Developmental Immunology, article number: 697340. (10.1155/2011/697340)
- Williams, D. W. and Lewis, M. A. O. 2011. Pathogenesis and treatment of oral candidosis. Journal of Oral Microbiology 3 (10.3402/jom.v3i0.5771)
- Williams, D. W., Chamary, N., Lewis, M. A. O., Milward, P. J. and McAndrew, R. 2011. Microbial contamination of removable prosthodontic appliances from laboratories and impact of clinical storage. British Dental Journal 211(4), pp. 163-166. (10.1038/sj.bdj.2011.675)
- Williams, D. W., Kuriyama, T., Silva, S., Malic, S. and Lewis, M. A. O. 2011. Candida biofilms and oral candidosis: Treatment and prevention. Periodontology 2000 55(1), pp. 250-265. (10.1111/j.1600-0757.2009.00338.x)
- Cairns, S. et al. 2011. Molecular analysis of microbial communities in endotracheal tube biofilms. PLoS ONE 6(3) (10.1371/journal.pone.0014759)
- Hooper, S. J., Lewis, M. A. O., Wilson, M. J. and Williams, D. W. 2011. Antimicrobial activity of Citrox (R) bioflavonoid preparations against oral microorganisms. British Dental Journal 210(1) (10.1038/sj.bdj.2010.1224)
- Silva, S., Henriques, M. C., Hayes, A. J., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Journal of Oral Pathology and Medicine 40(5), pp. 421-427. (10.1111/j.1600-0714.2010.00981.x)
- Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2011. Adherence and biofilm formation of non-Candida albicans Candida species. Trends in Microbiology 19(5), pp. 241-247. (10.1016/j.tim.2011.02.003)
- Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2011. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiology Reviews 36(2), pp. 288-305. (10.1111/j.1574-6976.2011.00278.x)
- Malic, S., Hill, K. E., Playle, R. A., Thomas, D. W. and Williams, D. W. 2011. In vitro interaction of chronic wound bacteria in biofilms. Journal of Wound Care 20(12), pp. 569-577.
- Williams, D. W., Marino, P. J., Thomas, J. G. and Lewis, M. A. O. 2011. The role of human oral microflora in ventilator- associated pneumonia. Annual Clinical Journal of Dental Health 1, pp. 16-21.
- Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2010. Silicone colonization by non-Candida albicans Candida species in the presence of urine. Journal of Medical Microbiology 59(7), pp. 747-754. (10.1099/jmm.0.017517-0)
- Hallier, C., Williams, D. W., Potts, A. J. C. and Lewis, M. A. O. 2010. A pilot study of bioaerosol reduction using an air cleaning system during dental procedures. British Dental Journal 209(8), article number: E14. (10.1038/sj.bdj.2010.975)
- Hill, K. E., Malic, S., McKee, R., Rennison, T., Harding, K. G., Williams, D. W. and Thomas, D. W. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65(6), pp. 1195-1206. (10.1093/jac/dkq105)
- Wise, M. P., Williams, D. W., Lewis, M. A. O. and Frost, P. J. 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key?. Critical care (London, England) 14(4), article number: 181. (10.1186/cc9084)
- Percival, S. L., Thomas, J. G. and Williams, D. W. 2010. Biofilms and bacterial imbalances in chronic wounds: Anti-Koch. International Wound Journal 7(3), pp. 169-175. (10.1111/j.1742-481X.2010.00668.x)
- Silva, S., Henriques, M., Oliveira, R., Williams, D. W. and Azeredo, J. 2010. In vitro biofilm activity of non-Candida albicans Candida species. Current Microbiology 61(6), pp. 534-540. (10.1007/s00284-010-9649-7)
- Tambo, T., Kuriyama, T., Karasawa, T., Yamamoto, E. and Williams, D. W. 2010. Genetic heterogeneity of prevotella strains involved in dentoalveolar abscess. Archives of Clinical Microbiology 1(4), article number: 4.
- Silva, S., Henriques, M., Oliveira, R., Azeredo, J., Malic, S., Hooper, S. J. and Williams, D. W. 2009. Characterization of Candida parapsilosis infection of an in vitro reconstituted human oral epithelium. European Journal of Oral Sciences 117(6), pp. 669-675. (10.1111/j.1600-0722.2009.00677.x)
- Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)
- Silva, S., Henriques, M., Martins, A., Oliveira, R., Williams, D. W. and Azeredo, J. 2009. Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition. Medical Mycology 47(7), pp. 681-689. (10.3109/13693780802549594)
- Wise, M. P., Williams, D. W., Lewis, M. A. O., Thomas, J. G. and Frost, P. J. 2008. Impact of poor dental health on pneumonia. European Respiratory Journal 32(4), pp. 1123-1124. (10.1183/09031936.00096808)
- Cairns, S. et al. 2008. Characterisation of biofilms within medical devices [Abstract]. Wound Repair and Regeneration 16(6), pp. A70. (10.1111/j.1524-475X.2008.00424.x)
- Shimizu, C., Kuriyama, T., Williams, D. W., Karasawa, T., Inoue, K., Nakagawa, K. and Yamamoto, E. 2008. Association of oral yeast carriage with specific host factors and altered mouth sensation. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 105(4), pp. 445-451. (10.1016/j.tripleo.2007.11.030)
- Williams, D. W. 2008. Characterisation of biofilms on epithelial surfaces by confocal microscopy. Wound Repair and Regeneration 16(6), pp. A69-A69.
- Wise, M. P., Cole, J. M., Williams, D. W., Lewis, M. A. O. and Frost, P. J. 2008. Efficacy of oral chlorhexidine in critical care [Letter]. Critical Care 12(3) (10.1186/cc6886)
- Malic, S., Hill, K. E., Ralphs, J. R., Hayes, A. J., Thomas, D. W., Potts, A. J. C. and Williams, D. W. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22(3), pp. 188-194. (10.1111/j.1399-302X.2007.00344.x)
- Noake, T., Kuriyama, T., White, P. L., Potts, A. J. C., Lewis, M. A. O., Williams, D. W. and Barnes, R. A. 2007. Antifungal susceptibility of Candida species using the Clinical and Laboratory Standards Institute disk diffusion and broth microdilution methods. Journal of Chemotherapy 19(3), pp. 283-287. (10.1179/joc.2007.19.3.283)
- Kuriyama, T. et al. 2007. Antimicrobial susceptibility of 800 anaerobic isolates from patients with dentoalveolar infection to 13 oral antibiotics. Oral Microbiology and Immunology 22(4), pp. 285-288. (10.1111/j.1399-302X.2007.00365.x)
- Pier-Francesco, A., Adams, R., Waters, M. G. J. and Williams, D. W. 2006. Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an in vitro study. Clinical Oral Implants Research 17(6), pp. 633-637. (10.1111/j.1600-0501.2006.01274.x)
- Williams, D. W., Iwahara, K., Kuriyama, T. and Shimura, S. 2006. Detection of cfxA and cfxA2, the β-lactamase genes of Prevotella spp., in clinical samples from dentoalveolar infection by real-time PCR. Journal of Clinical Microbiology 44(1), pp. 172-176. (10.1128/JCM.44.1.172-176.2006)
- Kuriyama, T., Karasawa, T., Williams, D. W., Nakagawa, K. and Yamamoto, E. 2006. An increased prevalence of β-lactamase-positive isolates in Japanese patients with dentoalveolar infection [Letter]. Journal of Antimicrobial Chemotherapy 58(3), pp. 708-709. (10.1093/jac/dkl287)
- Yanagisawa, M., Kuriyama, T., Williams, D. W., Nakagawa, K. and Karasawa, T. 2006. Proteinase Activity of Prevotella Species Associated with Oral Purulent Infection. Current Microbiology 52(5), pp. 375-378. (10.1007/s00284-005-0261-1)
- Kuriyama, T., Absi, E. G., Williams, D. W. and Lewis, M. A. O. 2005. An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance. British Dental Journal 198(12), pp. 759-763. (10.1038/sj.bdj.4812415)
- Price, C. L. et al. 2005. Reduced adherence of Candida to silane-treated silicone rubber. Journal of Biomedical Materials Research Part B: Applied Biomaterials 74B(1), pp. 481-487. (10.1002/jbm.b.30226)
- Kuriyama, T., Williams, D. W., Bagg, J., Coulter, W. A., Ready, D. and Lewis, M. A. O. 2005. In vitro susceptibility of oral Candida to seven antifungal agents. Oral Microbiology and Immunology 20(6), pp. 349-353. (10.1111/j.1399-302X.2005.00236.x)
- Bartie, K. L., Williams, D. W., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2004. Differential invasion of Candida albicans isolates in an in vitro model of oral candidosis. Oral Microbiology And Immunolology 19(5), pp. 293-296. (10.1111/j.1399-302X.2004.00155.x)
- White, P. L., Williams, D. W., Kuriyama, T., Samad, S. A., Lewis, M. A. O. and Barnes, R. A. 2004. Detection of Candida in concentrated oral rinse cultures by real-time PCR. Journal of clinical microbiology 42(5), pp. 2101-2107. (10.1128/JCM.42.5.2101-2107.2004)
- Williams, D. W. et al. 2004. Sex determination by PCR analysis of DNA extracted from incinerated, deciduous teeth. Science & Justice 44(2), pp. 89-94. (10.1016/S1355-0306(04)71694-9)
- Cross, L., Williams, D. W., Sweeney, C., Jackson, M., Lewis, M. A. O. and Bagg, J. 2004. Evaluation of the recurrence of denture stomatitis and Candida colonization in a small group of patients who received itraconazole. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 97(3), pp. 351-358. (10.1016/j.tripleo.2003.10.006)
- Kuriyama, T., Williams, D. W., Patel, M., Lewis, M. A. O., Jenkins, L. E., Hill, D. W. and Hosein, I. K. 2003. Molecular characterisation of clinical and environmental isolates of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis from a teaching hospital in Wales. Journal of Medical Microbiology 52(9), pp. 821-827. (10.1099/jmm.0.05123-0)
- Kuriyama, T., Williams, D. W. and Lewis, M. A. O. 2003. In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Microbiology and Immunology 18(6), pp. 405-407. (10.1046/j.0902-0055.2002.00100.x)
- Price, C., Waters, M. G. J., Williams, D. W., Lewis, M. A. O. and Stickler, D. J. 2002. Surface modification of an experimental silicone rubber aimed at reducing initial candidal adhesion. Journal of Biomedical Materials Research 63(2), pp. 122-128. (10.1002/jbm.10094)
- Bartie, K. L., Williams, D. W., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2001. PCR fingerprinting of Candida albicans associated with chronic hyperplastic candidosis and other oral conditions. Journal of clinical microbiology 39(11), pp. 4066-4075. (10.1128/JCM.39.11.4066-4075.2001)
- Wilson, M., Williams, D. W., Forbes, M., Finlay, I. G. and Lewis, M. A. O. 2001. A molecular epidemiological study of sequential oral isolates of Candida albicans from terminally ill patients. Journal Of Oral Pathology & Medicine 30(4), pp. 206-212. (10.1034/j.1600-0714.2001.300403.x)
- Williams, D. W., Bartie, K. L., Potts, A. J. C., Wilson, M., Fardy, M. J. and Lewis, M. A. O. 2001. Strain persistence of invasive Candida albicans in chronic hyperplastic candidosis that underwent malignant change. Gerodontology 18(2), pp. 73-78. (10.1111/j.1741-2358.2001.00073.x)
- Williams, D. W., Coulter, W. A., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2001. Identification of Candida dubliniensis, based on ribosomal DNA sequence analysis. British Journal of Biomedical Science 58(1), pp. 11-16.
- Bartie, K. L., Wilson, M., Williams, D. W. and Lewis, M. A. O. 2000. Macrorestriction fingerprinting of "Streptococcus milleri" group bacteria by pulsed-field gel electrophoresis. Journal of Clinical Microbiology 38(6), pp. 2141-2149.
- Williams, D. W. and Lewis, M. A. O. 2000. Oral microbiology: isolation and identification of candida from the oral cavity. Oral Diseases 6(1), pp. 3-11. (10.1111/j.1601-0825.2000.tb00314.x)
- Williams, D. W., Wilson, M., Potts, A. J. C. and Lewis, M. A. O. 2000. Phenotypic characterisation of Candida albicans isolated from chronic hyperplastic candidosis. Journal of Medical Microbiology 49(2), pp. 199-202.
- Williams, D. W., Waters, M. G. J., Potts, A. J. C. and Lewis, M. A. O. 1998. A novel technique for assessment of adherence of Candida albicans to solid surfaces. Journal of Clinical Pathology 51(5), pp. 390-391. (10.1136/jcp.51.5.390)
- Williams, D. W., Jones, H. S., Allison, R. T., Potts, A. J. C. and Lewis, M. A. O. 1998. Immunocytochemical detection of Candida albicans in formalin fixed, paraffin embedded material. Journal of Clinical Pathology 51(11), pp. 857-859. (10.1136/jcp.51.11.857)
- Waters, M. G. J., Williams, D. W., Jagger, R. G. and Lewis, M. A. O. 1997. Adherence of Candida albicans to experimental denture soft lining materials. Journal of Prosthetic Dentistry 77(3), pp. 306-312. (10.1016/S0022-3913(97)70188-4)
- Williams, D. W., Potts, A. J. C., Wilson, M., Matthews, J. B. and Lewis, M. A. O. 1997. Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa. Journal of Oral Pathology & Medicine 26(2), pp. 83-89. (10.1111/j.1600-0714.1997.tb00026.x)
- Williams, D. W., Wilson, M., Lewis, M. A. O. and Potts, A. J. C. 1996. Identification of Candida species in formalin fixed, paraffin wax embedded oral mucosa by sequencing of ribosomal DNA. Clinical Molecular Pathology 49, pp. M23-M28. (10.1136/mp.49.1.M23)
- Williams, D. W., Wilson, M., Lewis, M. A. O. and Potts, A. J. C. 1995. Identification of Candida species by PCR and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal DNA. Journal of Clinical Microbiology 33(9), pp. 2476-2479.
- Nicholas, R. O., Williams, D. W. and Hunter, P. A. 1994. Investigation of the value of β-glucan-specific fluorochromes for predicting the β-glucan content of the cell walls of zoopathogenic fungi. Mycological Research 98(6), pp. 694-698. (10.1016/S0953-7562(09)80419-X)
Llyfrau
- Percival, S. L. et al. eds. 2014. Biofilms in infection prevention and control: A healthcare handbook. London: Elsevier.
- Percival, S. L., Yates, M. V., Williams, D. W., Chalmers, R. M. and Gray, N. F. 2013. Microbiology of waterborne diseases: microbiological aspects and risks. London: Elsevier.
- Marsh, P. D., Martin, M. V., Williams, D. W. and Lewis, M. A. O. 2009. Oral microbiology. 5th ed.. London: Churchill Livingstone.
- Mariyaselvam, M. Z., Marsh, L., Bamford, S., Smith, A., Wise, M. and Williams, D. 2017. Endotracheal tubes and fluid aspiration: An in vitro evaluation of new cuff technologies. BMC Anesthesiology 17, article number: 36. (10.1186/s12871-017-0328-0)
- Alves, C. T., Wei, X., Silva, S., Azeredo, J., Henriques, M. and Williams, D. W. 2014. Candida albicans promotes invasion and colonisation of Candida glabrata in a reconstituted human vaginal epithelium. Journal of Infection 69(4), pp. 396-407. (10.1016/j.jinf.2014.06.002)
- Boros-Majewska, J. et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology 203(5), pp. 341-355. (10.1007/s00430-014-0343-4)
- Malic, S., Waters, M. G. J., Basil, L., Stickler, D. J. and Williams, D. W. 2012. Development of an 'early warning' sensor for encrustation of urinary catheters following Proteus infection. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B(1), pp. 133-137. (10.1002/jbm.b.31930)
- Silva, S., Hooper, S. J., Henriques, M., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa. Clinical Microbiology and Infection 17(2), pp. 264-272. (10.1111/j.1469-0691.2010.03248.x)
- Cairns, S. et al. 2011. Molecular analysis of microbial communities in endotracheal tube biofilms. PLoS ONE 6(3) (10.1371/journal.pone.0014759)
- Silva, S., Henriques, M. C., Hayes, A. J., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Journal of Oral Pathology and Medicine 40(5), pp. 421-427. (10.1111/j.1600-0714.2010.00981.x)
- Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)
Ymchwil
My research interests primarily focus in the field of oral microbiology and microbial biofilms. Previous research has been directed towards elucidating the role of Candida in chronic hyperplastic candidosis (CHC), which led to the development of novel genotypic methods for identifying Candida species in fixed tissues. The significance of this work was recognised through receipt of both the Colgate Prize and the IADR/Unilever Hatton Award. Additional Candida research has included the study of antifungal susceptibility of Candida species, virulence gene expression and real-time PCR detection of Candida in oral samples. I have also investigated interaction of Candida with associated bacteria in oral tissue and on medical devices (e.g. silicone rubber, acrylic, and titanium). The invasive properties of Candida based on in vitro tissue models has successfully revealed strain and species variation which could have significance in disease progression. Research in this area has benefited through collaboration with colleagues at the University of Minho, Braga, Portugal, the Gdansk Institute of Technology, Gdansk, Poland, and the Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. Recently, I have also been involved in studies aimed at elucidating the innate immune response to Candida through cytokine signalling and subsequent T-cell differentiation.
Additional biofilm research projects have included the study of biofilms in endotracheal tubes and their role in ventilator-associated pneumonia, a leading cause of mortality in intensive care units. This work was initiated and continues to develop through close collaboration with Professor J Thomas (University of West Virginia, USA).
Urinary tract catheter biofilms continue to be a leading cause of healthcare associated infection and with industrial collaboration together with colleagues at the Bristol Urological Institute we have developed medical devices to aid in the management of these infections.
Chronic wounds are those that do not heal within an expected time-frame and represent a significant cause of patient morbidity and increased healthcare costs. One potential factor involved in delayed wound healing is the presence of microbial biofilms within the wound which are often recalcitrant to antibiotic therapy. Our research has not only characterised these biofilms through culture and molecular analysis but also focused on mechanisms to rapidly detect pathogenic bacterial biofilms within the tissue.
Research Projects:
1. Candida and host interactions associated with colonisation and infection
2. The role of the oral flora in promoting pneumonia in artificially ventilated patients
3. Dynamics of dental plaque biofilms in intensive care patients
4. Structure, activity and gene expression of Candida albicans biofilms developed on biotic surfaces
5. Denture acrylic surface topography and effect on microbial colonisation
6. Role of polymorphisms in the dectin-1 gene in determining the risk of candidal colonisation and infection in critically ill patient in intensive care units
Addysgu
I teach a variety of subjects associated with Oral Microbiology for the dental undergraduate course and for additional postgraduate courses. My teaching responsibilities comprise lectures, seminars, practical classes and student assessment. I am a full member of the The Higher Education Academy and a member of the Association of Basic Science Teachers in Dentistry (ABSTD). In terms of external teaching contributions I examine for PhD, MPhil, and MSc students and I am external examiner for The Integrated Human Diseases (IHD) Course Sheffield University (2014-present) and BDS Part 1 within King's College London (2014-present).
Bywgraffiad
2013-Present Professor of Oral Microbiology (Cardiff University) I teach a variety of subjects associated with Oral Microbiology for the dental undergraduate course and for additional postgraduate courses. My teaching responsibilities comprise lectures, seminars, practical classes and student assessment. I am a full member of the The Higher Education Academy and a member of the Association of Basic Science Teachers in Dentistry (ABSTD). Past and current - External Examiner for PhD, MPhil, MSc, The Integrated Human Diseases (IHD) Course Sheffield University (2014-present) International Association of Dental Research (IADR) IADR-PER, Helsinki, Finland, 2013 Personal awards: Senior Colgate Prize (1996, BSDR) Associated Undergraduate/Postgraduate/Postdoctoral Awards: Franklyn Williams Elective 2004Career Profile
2007- 2013 Reader in Oral Microbiology (Cardiff University)
2003-2007 Senior Lecturer in Oral Microbiology (Cardiff University)
1999-2003 Lecturer in Oral Microbiology (UWCM)
1997-1999 Postdoctoral Research Fellow (UWCM)
1994 Diploma in Biomedical Methods (with Distinction)
1993-1996 MRC PhD Studentship (UWCM)
1987-1993 Research Officer (Leatherhead Food Research Association)
1983-1987 BSc (Hons.) Applied Biology (First Class) (UWCC)Teaching Profile
External Assessment
Memberships / External Activities
British Society of Oral and Dental Research (BSODR), and Honorary Secretary (2011-present)
British Society of Medical Mycology (BSMM)
Association of Basic Science Teachers in Dentistry (ABSTD)
Association of Clinical Oral Microbiologists (ACOM)
The Higher Education Academy
Cardiff Institute of Tissue Engineering and Repair (CITER)
Oral Microbiology and Immunology Group (OMIG), and committee member (2011-present)
Oral Medicine and Pathology Group (OMPG)
Editorial board member of the Journal, Oral Microbiology and ImmunologyInvited Lectures
Additional International Presentations
IADR Seattle, USA
IADR Iguazu Falls, Brazil, 2012
IADR, San Diego, USA, 2011
IADR, Toronto, Canada, 2008
IADR, Honolulu, USA, 2004
IADR, San Diego, USA, 2002
IADR, Washington, USA, 2000
IADR/PEF, Nice, France, 1998
IADR, Florida, USA, 1997Awards and Prizes
Edward H Hatton Award (1997, IADR)
PPP Foundation Poster Competition (3rd prize; 2002)
Dental Protection Society Premiere Award (2nd prize; 2002)
Dentsply Student Clinician Award (2002)
Graduate School in Biomedical and Life Sciences Travel Grant (2006)
Bristol Urological Institute Prize Innovation (2009)
Anrhydeddau a dyfarniadau
Dyfarniadau personol:
Gwobr Uwch Colgate (1996, BSDR)
Gwobr Edward H Hatton (1997)
Gwobrau Israddedig/Ôl-raddedig / Ôl-ddoethurol cysylltiedig:
Franklyn Williams yn Ddewisol 2004
Cystadleuaeth Poster Sylfaen PPP (3ydd gwobr; 2002)
Gwobr Premiere Cymdeithas Diogelu Deintyddol (2il wobr; 2002)
Gwobr Glinigwr Myfyrwyr Dentsply (2002)
Grant Teithio Ysgol i Raddedigion mewn Gwyddorau Biofeddygol a Bywyd (2006)
Arloesedd Gwobr Sefydliad Wrolegol Bryste (2009)
Gwobr Poster Simon Foundation (2011)
Aelodaethau proffesiynol
Cymdeithas Ryngwladol Ymchwil Ddeintyddol (IADR)
Cymdeithas Ymchwil Llafar a Deintyddol Prydain (BSODR), ac yn flaenorol Ysgrifennydd Anrhydeddus
British Society of Medical Mycology (BSMM)
Cymdeithas Athrawon Gwyddoniaeth Sylfaenol mewn Deintyddiaeth (ABSTD)
Cymdeithas Microbiolegwyr Llafar Clinigol (ACOM)
Yr Academi Addysg Uwch
Sefydliad Peirianneg a Thrwsio Meinwe Caerdydd (CITER)
Grŵp Microbioleg ac Imiwnoleg Llafar (OMIG), ac aelod o'r pwyllgor (2011-presennol)
Grŵp Meddygaeth Lafar a Phatholeg (OMPG)
Safleoedd academaidd blaenorol
1. Darllenydd mewn Microbioleg Lafar 2007-2013, Ysgol Deintyddiaeth, Prifysgol Caerdydd.
2. Uwch-ddarlithydd mewn Microbioleg Lafar 2003-2007, Prifysgol Caerdydd.
3. Darlithydd mewn Microbiolgi Llafar 1999-2003, Prifysgol Caerdydd.
Pwyllgorau ac adolygu
Aelod o fwrdd golygyddol y Journal of Oral Microbiology
Aelod bwrdd golygyddol Pathogenau
Aelod bwrdd golygyddol o Bioffilmiau (adran arbenigedd Frontiers in Cellular and Infection Microbiology)
Adolygydd Grant, MRC, BBSRC, NBIC
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PhD ym meysydd:
- Datblygiad bioffilm
- Haint geneuol
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