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Professor David Williams
- Available for postgraduate supervision
Teams and roles for David Williams
Theme Lead for Oral and Biomedical Sciences, Professor of Oral Microbiology, School of Dentistry
Overview
Professor of Oral Microbiology at the School of Dentistry with a research focus in microbial biofilms.
Publication
2025
- Domzaridou, E. et al., 2025. Treatment persistence and variations in prescribing oral, injectable, and inhaled corticosteroids: a population-based drug utilisation study. Pharmacoepidemiology & Drug Safety 34 (5) e70153. (10.1002/pds.70153)
- Kuriyama, T. et al., 2025. Bacterial Infections of the oral and maxillofacial region. In: Anderson, L. et al., Oral and Maxillofacial Surgery. Wiley. , pp.401-473. (10.1002/9781119842958.ch4.1)
- Nassar, R. et al. 2025. Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region. International Endodontic Journal (10.1111/iej.14227)
- Pan, J. et al., 2025. Influence of the ATP-dependent DNA ligase, Lig E, on Neisseria gonorrhoeae microcolony and biofilm formation. Biofilm 10 100292. (10.1016/j.bioflm.2025.100292)
- Vanhatalo, A. et al., 2025. Ageing modifies the oral microbiome, nitric oxide bioavailability and vascular responses to dietary nitrate supplementation. Free Radical Biology and Medicine 238 , pp.682-696. (10.1016/j.freeradbiomed.2025.07.002)
- Williams, D. W. , Kuriyama, T. and Lewis, M. A. O. 2025. Oral fungal infections. In: Anderson, L. et al., Oral and Maxillofacial Surgery. Wiley. , pp.474-480. (10.1002/9781119842958.ch4.2)
- Williams, D. W. , Kuriyama, T. and Lewis, M. A. O. 2025. Orofacial viral infections. In: Anderson, L. , Odont, D. and Krishnan, D. G. eds. Oral and Maxillofacial Surgery. Wiley. , pp.481-490. (10.1002/9781119842958.ch4.3)
2023
- Board-Davies, E. L. et al. 2023. Antimicrobial effects of XF drugs against Candida albicans and its biofilms. Frontiers in Fungal Biology 4 1225647. (10.3389/ffunb.2023.1225647)
- Martorano-Fernandes, L. et al., 2023. Epithelial responses and Candida albicans pathogenicity are enhanced in the presence of oral streptococci.. Brazilian Dental Journal 34 (3), pp.73-81. (10.1590/0103-6440202305420)
- Nassar, R. et al. 2023. Phytic acid demonstrates rapid antibiofilm activity and inhibits biofilm formation when used as a surface conditioning agent. Microbiology Spectrum 11 (3) e00267-23. (10.1128/spectrum.00267-23)
- Serpi, M. et al. 2023. Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites. Journal of Molecular Structure 1278 134977. (10.1016/j.molstruc.2023.134977)
- Serrano-Diaz, P. et al., 2023. Geranium leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on Candida albicans. Green Processing and Synthesis 12 (1) 202281. (10.1515/gps-2022-8105)
- Twigg, J. A. et al. 2023. Compositional shifts within the denture-associated bacteriome in pneumonia – an analytical cross-sectional study. Journal of Medical Microbiology 72 (6)(10.1099/jmm.0.001702)
2022
- Board-Davies, E. L. et al. 2022. Antibacterial and antibiofilm potency of XF drugs, impact of photodynamic activation and synergy with antibiotics.. Frontiers in Cellular and Infection Microbiology 12 904465. (10.3389/fcimb.2022.904465)
2021
- Nassar, M. et al. 2021. Phytic acid: properties and potential applications in dentistry. Frontiers in Materials 8 638909. (10.3389/fmats.2021.638909)
- Nassar, R. et al. 2021. Microbial metabolic genes crucial for S. aureus biofilms: an insight from re-analysis of publicly available microarray datasets. Frontiers in Microbiology 11 607002. (10.3389/fmicb.2020.607002)
- Nassar, R. et al. 2021. Antimicrobial activity of phytic acid: an emerging agent in dentistry. Frontiers in Cellular and Infection Microbiology 11 753649. (10.3389/fcimb.2021.753649)
- Vanhatalo, A. et al., 2021. Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions. Redox Biology 41 101933. (10.1016/j.redox.2021.101933)
- Williams, A. et al. 2021. Higher number of EBI3 cells in mucosal chronic hyperplastic candidiasis may serve to regulate IL-17 producing cells. Journal of Fungi 7 (7) 533. (10.3390/jof7070533)
2020
- Henriques, M. and Williams, D. 2020. Pathogenesis and virulence of Candida albicans and Candida glabrata. Pathogens 9 (9) 752. (10.3390/pathogens9090752)
- Serra, E. et al., 2020. Methylcellulose hydrogel with melissa officinalis essential oil as a potential treatment for oral candidiasis. Microorganisms 8 (2) 215. (10.3390/microorganisms8020215)
- Smith, A. et al., 2020. The effect of residual food stain on microbial colonisation of denture acrylics with the increase of Candida albicans. Dental Oral Biology and Craniofacial Research 3 (2), pp.2-5. (10.31487/j.DOBCR.2020.02.06)
- Yee Lim, S. et al., 2020. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International Journal of Pharmaceutics 573 118860. (10.1016/j.ijpharm.2019.118860)
2019
- Lins, R. X. et al., 2019. Comparison of genotypes, antimicrobial resistance and virulence profiles of oral and non oral Enterococcus faecalis from Brazil, Japan and the United Kingdom. Journal of dentistry 84 , pp.49-54. (10.1016/j.jdent.2019.03.002)
- Morse, D. et al. 2019. Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria. Letters in Applied Microbiology 68 (4), pp.337-343. (10.1111/lam.13145)
- Morse, D. J. et al. 2019. Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. Scientific Reports 9 10228. (10.1038/s41598-019-46494-0)
- Williams, A. et al. 2019. Immunohistochemical expression patterns of inflammatory cells involved in Chronic Hyperplastic Candidosis. Pathogens 8 (4) 232. (10.3390/pathogens8040232)
2018
- Morse, D. et al. 2018. Denture-associated biofilm infection in 3-dimensional 1 oral mucosal tissue models. Journal of Medical Microbiology 67 (3), pp.364-375. (10.1099/jmm.0.000677)
- Pinto, S. d. S. et al., 2018. Antimicrobial activity of per acetic acid for trans-operative disinfection of endodontic files. International Journal of Advanced Engineering Research and Science 5 (11), pp.132. (10.22161/ijaers.5.11.18)
- Serra, E. et al. 2018. Antifungal activity of commercial essential oils and biocides against Candida albicans. Pathogens 7 (1) 15. (10.3390/pathogens7010015)
- Vanhatalo, A. et al., 2018. Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Free Radical Biology and Medicine 124 , pp.21-30. (10.1016/j.freeradbiomed.2018.05.078)
2017
- Lewis, M. and Williams, D. 2017. Diagnosis and management of oral candidosis. British Dental Journal 223 , pp.675 -681. (10.1038/sj.bdj.2017.886)
- Marino, P. J. et al. 2017. Community analysis of dental plaque and endotracheal tube biofilms from mechanically ventilated patients. Journal of Critical Care 39 , pp.149-155. (10.1016/j.jcrc.2017.02.020)
- Mariyaselvam, M. Z. et al., 2017. Endotracheal tubes and fluid aspiration: An in vitro evaluation of new cuff technologies. BMC Anesthesiology 17 36. (10.1186/s12871-017-0328-0)
- Sands, K. M. et al. 2017. Respiratory pathogen colonisation of dental plaque, the lower airways and endotracheal tube biofilms during mechanical ventilation. Journal of Critical Care 37 , pp.30-37. (10.1016/j.jcrc.2016.07.019)
2016
- Benjamin, T. et al., 2016. A novel approach to antibiofilm susceptibility testing using a thermo-reversible matrix. Journal of Wound Care 25 (2), pp.62-67. (10.12968/jowc.2016.25.2.62)
- Cavalcanti, Y. W. et al., 2016. Salivary pellicles equalise surfaces' charges and modulate the virulence of Candida albicans biofilm. Archives of Oral Biology 66 , pp.129-140. (10.1016/j.archoralbio.2016.02.016)
- Cavalcanti, Y. W. et al., 2016. Modulation of Candida albicansvirulence by bacterial biofilms on titanium surfaces. Biofouling 32 (2), pp.123-134. (10.1080/08927014.2015.1125472)
- Dantas de Almeida, L. d. F. et al., 2016. Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms. Acta Odontologica Scandinavica 74 (5), pp.393-398. (10.3109/00016357.2016.1166261)
- Marino, P. J. et al. 2016. Comparison of foam swabs and toothbrushes as oral hygiene interventions in mechanically ventilated patients: a randomised split mouth study. BMJ Open Respiratory Research 2016 (3) e000150. (10.1136/bmjresp-2016-000150)
- Sands, K. M. et al. 2016. Microbial profiling of dental plaque from mechanically ventilated patients. Journal of Medical Microbiology 65 (2), pp.147-159. (10.1099/jmm.0.000212)
2015
- Boros-Majewska, J. et al., 2015. A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukemic cells infected with Candida albicans. Journal of Applied Microbiology 119 (1), pp.177-187. (10.1111/jam.12817)
- Cavalcanti, Y. W. et al., 2015. Virulence and pathogenicity of Candida albicans is enhanced in biofilms containing oral bacteria. Biofouling 31 (1), pp.27-38. (10.1080/08927014.2014.996143)
- Jordan, R. P. C. et al. 2015. Development of an antimicrobial urinary catheter to inhibit urinary catheter encrustation. Microbiology Discovery 3 (1) 1. (10.7243/2052-6180-3-1)
- Mariyaselvam, M. Z. , Wise, M. P. and Williams, D. W. 2015. Translating in vitro research: Improving endotracheal tube bench test methodology [Letter]. American Journal of Respiratory and Critical Care Medicine 192 (5), pp.642. (10.1164/rccm.201505-0956LE)
- Xu, R. et al., 2015. IL-34 suppresses 'Candida albicans' induced TNFα production in M1 macrophages by downregulating expression of Dectin-1 and TLR2. Journal of Immunology Research 2015 328146. (10.1155/2015/328146)
2014
- Alves, C. T. et al., 2014. Effect of progesterone on candida albicans vaginal pathogenicity. International Journal of Medical Microbiology 304 (8), pp.1011-1017. (10.1016/j.ijmm.2014.07.004)
- Alves, C. T. et al., 2014. Candida albicans promotes invasion and colonisation of Candida glabrata in a reconstituted human vaginal epithelium. Journal of Infection 69 (4), pp.396-407. (10.1016/j.jinf.2014.06.002)
- Boros-Majewska, J. et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology 203 (5), pp.341-355. (10.1007/s00430-014-0343-4)
- Jordan, R. P. C. et al. 2014. Comparative adherence of Candida albicans and Candida dubliniensis to human buccal epithelial cells and extracellular matrix proteins. Medical Mycology 52 (3), pp.254-263. (10.1093/mmy/myt032)
- Malic, S. et al., 2014. Biocide activity against urinary catheter pathogens. Antimicrobial Agents and Chemotherapy 58 (2), pp.1192-1194. (10.1128/AAC.01106-13)
- Sands, K. M. et al. 2014. Mechanisms of augmented growth of Pseudomonas aeruginosa mediated by Candida albicans [Letter]. Critical Care Medicine 42 (3), pp.e256. (10.1097/CCM.0000000000000113)
2013
- Almalioti, F. et al. 2013. Convenient syntheses of cyanuric chloride-derived NHC ligands, their Ag(i) and Au(i) complexes and antimicrobial activity. Dalton Transactions 42 (34), pp.12370-12380. (10.1039/c3dt51400e)
- Daw, A. E. et al. 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28 (1), pp.144-160. (10.1177/0885328212441495)
- Malic, S. et al. 2013. Antimicrobial activity of novel mouthrinses against planktonic cells and biofilms of pathogenic microorganisms. Microbiology Discovery 1 11. (10.7243/2052-6180-1-11)
- Percival, S. L. et al., 2013. Microbiology of waterborne diseases: microbiological aspects and risks. London: Elsevier.
- Rogers, H. et al. 2013. Immune response and candidal colonisation in denture associated stomatitis. Journal of Clinical & Cellular Immunology 4 (6) 178. (10.4172/2155-9899.1000178)
- Rogers, H. et al. 2013. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clinical and Developmental Immunology 2013 320168. (10.1155/2013/320168)
- Sands, K. M. et al. 2013. The dynamics of polymicrobial biofilms [Letter]. American Journal of Respiratory and Critical Care Medicine 188 (10), pp.1266. (10.1164/rccm.201305-0916LE)
- Silva, S. et al., 2013. The effect of silver nanoparticles and nystatin on mixed biofilms of Candida glabrata and Candida albicans on acrylic. Medical Mycology 51 (2), pp.178-184. (10.3109/13693786.2012.700492)
- Williams, D. W. et al. 2013. Interactions of Candida albicans with host epithelial surfaces. Journal of Oral Microbiology 5 22434. (10.3402/jom.v5i0.22434)
- Ximenes Lins, R. et al., 2013. Antimicrobial resistance and virulence traits of Enterococcus faecalis from primary endodontic infections. Journal of Dentistry 41 (9), pp.779-786. (10.1016/j.jdent.2013.07.004)
- Zheng, X. F. et al., 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8 (5) e63967. (10.1371/journal.pone.0063967)
2012
- Hooper, S. J. et al. 2012. The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal 9 (6), pp.633-642. (10.1111/j.1742-481X.2012.00927.x)
- Hooper, S. J. et al. 2012. An in vitro comparison of two silver- containing antimicrobial wound dressings. Ostomy Wound Management 58 (1), pp.16-22.
- Landrygan-Bakri, J. et al., 2012. Real-time monitoring of adherence of Streptococcus anginosus group bacteria to extracellular matrix decorin and biglycan proteoglycans in biofilm formation. Research in Microbiology 163 (6-7), pp.436-447. (10.1016/j.resmic.2012.07.006)
- Mahmoud, H. M. et al. 2012. Influence of extracellular matrix proteins in enhancing bacterial adhesion to titanium surfaces. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B (5), pp.1319-1327. (10.1002/jbm.b.32698)
- Malic, S. et al. 2012. Development of an 'early warning' sensor for encrustation of urinary catheters following Proteus infection. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B (1), pp.133-137. (10.1002/jbm.b.31930)
- Percival, S. L. et al., 2012. Microbiology of the skin and the role of biofilms in infection. International Wound Journal 9 (1), pp.14-32. (10.1111/j.1742-481X.2011.00836.x)
- Percival, S. L. et al., 2012. A review of the scientific evidence for biofilms in wounds. Wound Repair and Regeneration 20 (5), pp.647-657. (10.1111/j.1524-475X.2012.00836.x)
- Wagstaffe, S. J. et al., 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84 (14), pp.5876-5884. (10.1021/ac203403d)
- Wildeboer, D. et al., 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31 (9), pp.2183-2189. (10.1007/s10096-012-1553-6)
2011
- Cairns, S. et al. 2011. Molecular analysis of microbial communities in endotracheal tube biofilms. PLoS ONE 6 (3)(10.1371/journal.pone.0014759)
- Hooper, S. J. et al. 2011. Antimicrobial activity of Citrox (R) bioflavonoid preparations against oral microorganisms. British Dental Journal 210 (1)(10.1038/sj.bdj.2010.1224)
- Malic, S. et al. 2011. In vitro interaction of chronic wound bacteria in biofilms. Journal of Wound Care 20 (12), pp.569-577.
- Marino, P. et al. 2011. Effects of oral microbes on biofilm formation by respiratory pathogens. Presented at: 2011 IADR/AADR/CADR General Session San Diego, CA, USA 19 March 2011.
- Percival, S. L. et al., 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19 (1), pp.1-9. (10.1111/j.1524-475X.2010.00651.x)
- Percival, S. L. et al., 2011. Introduction to biofilms. In: Percival, S. L. , Kottenbelt, D. C. and Cochrane, C. A. eds. Biofilms and Veterinary Medicine. Springer Series on Biofilms Vol. 6.London: Springer. , pp.41-68. (10.1007/978-3-642-21289-5_2)
- Silva, S. et al., 2011. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Journal of Oral Pathology and Medicine 40 (5), pp.421-427. (10.1111/j.1600-0714.2010.00981.x)
- Silva, S. et al., 2011. Adherence and biofilm formation of non-Candida albicans Candida species. Trends in Microbiology 19 (5), pp.241-247. (10.1016/j.tim.2011.02.003)
- Silva, S. et al., 2011. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiology Reviews 36 (2), pp.288-305. (10.1111/j.1574-6976.2011.00278.x)
- Silva, S. et al., 2011. The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa. Clinical Microbiology and Infection 17 (2), pp.264-272. (10.1111/j.1469-0691.2010.03248.x)
- Wei, X. et al. 2011. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Clinical & Developmental Immunology 697340. (10.1155/2011/697340)
- Williams, D. W. et al. 2011. Microbial contamination of removable prosthodontic appliances from laboratories and impact of clinical storage. British Dental Journal 211 (4), pp.163-166. (10.1038/sj.bdj.2011.675)
- Williams, D. W. et al. 2011. Candida biofilms and oral candidosis: Treatment and prevention. Periodontology 2000 55 (1), pp.250-265. (10.1111/j.1600-0757.2009.00338.x)
- Williams, D. W. and Lewis, M. A. O. 2011. Pathogenesis and treatment of oral candidosis. Journal of Oral Microbiology 3 (10.3402/jom.v3i0.5771)
- Williams, D. W. et al. 2011. The role of human oral microflora in ventilator- associated pneumonia. Annual Clinical Journal of Dental Health 1 , pp.16-21.
2010
- Hallier, C. et al., 2010. A pilot study of bioaerosol reduction using an air cleaning system during dental procedures. British Dental Journal 209 (8) E14. (10.1038/sj.bdj.2010.975)
- Hill, K. E. et al. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65 (6), pp.1195-1206. (10.1093/jac/dkq105)
- Kuriyama, T. , Lewis, M. A. O. and Williams, D. W. 2010. Infections of the oral and maxillofacial region. In: Andersson, L. , Kahnberg, K. and Pogrel, M. A. eds. Oral and Maxillofacial Surgery. Chichester: Wiley. , pp.467-582.
- Percival, S. L. , Thomas, J. G. and Williams, D. W. 2010. Biofilms and bacterial imbalances in chronic wounds: Anti-Koch. International Wound Journal 7 (3), pp.169-175. (10.1111/j.1742-481X.2010.00668.x)
- Silva, S. et al., 2010. In vitro biofilm activity of non-Candida albicans Candida species. Current Microbiology 61 (6), pp.534-540. (10.1007/s00284-010-9649-7)
- Silva, S. et al., 2010. Silicone colonization by non-Candida albicans Candida species in the presence of urine. Journal of Medical Microbiology 59 (7), pp.747-754. (10.1099/jmm.0.017517-0)
- Tambo, T. et al., 2010. Genetic heterogeneity of prevotella strains involved in dentoalveolar abscess. Archives of Clinical Microbiology 1 (4) 4.
- Wise, M. P. et al. 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key?. Critical care (London, England) 14 (4) 181. (10.1186/cc9084)
2009
- Malic, S. et al. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155 , pp.2603-2611. (10.1099/mic.0.028712-0)
- Marsh, P. D. et al., 2009. Oral microbiology. 5th ed.. London: Churchill Livingstone.
- Silva, S. et al., 2009. Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition. Medical Mycology 47 (7), pp.681-689. (10.3109/13693780802549594)
- Silva, S. et al., 2009. Characterization of Candida parapsilosis infection of an in vitro reconstituted human oral epithelium. European Journal of Oral Sciences 117 (6), pp.669-675. (10.1111/j.1600-0722.2009.00677.x)
2008
- Cairns, S. et al. 2008. Characterisation of biofilms within medical devices [Abstract]. Wound Repair and Regeneration 16 (6), pp.A70. (10.1111/j.1524-475X.2008.00424.x)
- Shimizu, C. et al., 2008. Association of oral yeast carriage with specific host factors and altered mouth sensation. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 105 (4), pp.445-451. (10.1016/j.tripleo.2007.11.030)
- Williams, D. W. 2008. Characterisation of biofilms on epithelial surfaces by confocal microscopy. Wound Repair and Regeneration 16 (6), pp.A69-A69.
- Wise, M. P. et al. 2008. Efficacy of oral chlorhexidine in critical care [Letter]. Critical Care 12 (3)(10.1186/cc6886)
- Wise, M. P. et al. 2008. Impact of poor dental health on pneumonia. European Respiratory Journal 32 (4), pp.1123-1124. (10.1183/09031936.00096808)
2007
- Kuriyama, T. et al., 2007. Antimicrobial susceptibility of 800 anaerobic isolates from patients with dentoalveolar infection to 13 oral antibiotics. Oral Microbiology and Immunology 22 (4), pp.285-288. (10.1111/j.1399-302X.2007.00365.x)
- Malic, S. et al. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22 (3), pp.188-194. (10.1111/j.1399-302X.2007.00344.x)
- Noake, T. et al., 2007. Antifungal susceptibility of Candida species using the Clinical and Laboratory Standards Institute disk diffusion and broth microdilution methods. Journal of Chemotherapy 19 (3), pp.283-287. (10.1179/joc.2007.19.3.283)
2006
- Kuriyama, T. et al. 2006. An increased prevalence of β-lactamase-positive isolates in Japanese patients with dentoalveolar infection [Letter]. Journal of Antimicrobial Chemotherapy 58 (3), pp.708-709. (10.1093/jac/dkl287)
- Pier-Francesco, A. et al., 2006. Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an in vitro study. Clinical Oral Implants Research 17 (6), pp.633-637. (10.1111/j.1600-0501.2006.01274.x)
- Williams, D. W. et al. 2006. Detection of cfxA and cfxA2, the β-lactamase genes of Prevotella spp., in clinical samples from dentoalveolar infection by real-time PCR. Journal of Clinical Microbiology 44 (1), pp.172-176. (10.1128/JCM.44.1.172-176.2006)
- Yanagisawa, M. et al., 2006. Proteinase Activity of Prevotella Species Associated with Oral Purulent Infection. Current Microbiology 52 (5), pp.375-378. (10.1007/s00284-005-0261-1)
2005
- Kuriyama, T. et al., 2005. An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance. British Dental Journal 198 (12), pp.759-763. (10.1038/sj.bdj.4812415)
- Kuriyama, T. et al. 2005. In vitro susceptibility of oral Candida to seven antifungal agents. Oral Microbiology and Immunology 20 (6), pp.349-353. (10.1111/j.1399-302X.2005.00236.x)
- Price, C. L. et al., 2005. Reduced adherence of Candida to silane-treated silicone rubber. Journal of Biomedical Materials Research Part B: Applied Biomaterials 74B (1), pp.481-487. (10.1002/jbm.b.30226)
2004
- Bartie, K. L. et al., 2004. Differential invasion of Candida albicans isolates in an in vitro model of oral candidosis. Oral Microbiology And Immunolology 19 (5), pp.293-296. (10.1111/j.1399-302X.2004.00155.x)
- Cross, L. et al., 2004. Evaluation of the recurrence of denture stomatitis and Candida colonization in a small group of patients who received itraconazole. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 97 (3), pp.351-358. (10.1016/j.tripleo.2003.10.006)
- White, P. L. et al., 2004. Detection of Candida in concentrated oral rinse cultures by real-time PCR. Journal of clinical microbiology 42 (5), pp.2101-2107. (10.1128/JCM.42.5.2101-2107.2004)
- Williams, D. W. et al. 2004. Sex determination by PCR analysis of DNA extracted from incinerated, deciduous teeth. Science & Justice 44 (2), pp.89-94. (10.1016/S1355-0306(04)71694-9)
2003
- Kuriyama, T. , Williams, D. W. and Lewis, M. A. O. 2003. In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Microbiology and Immunology 18 (6), pp.405-407. (10.1046/j.0902-0055.2002.00100.x)
- Kuriyama, T. et al., 2003. Molecular characterisation of clinical and environmental isolates of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis from a teaching hospital in Wales. Journal of Medical Microbiology 52 (9), pp.821-827. (10.1099/jmm.0.05123-0)
2002
- Price, C. et al., 2002. Surface modification of an experimental silicone rubber aimed at reducing initial candidal adhesion. Journal of Biomedical Materials Research 63 (2), pp.122-128. (10.1002/jbm.10094)
2001
- Bartie, K. L. et al., 2001. PCR fingerprinting of Candida albicans associated with chronic hyperplastic candidosis and other oral conditions. Journal of clinical microbiology 39 (11), pp.4066-4075. (10.1128/JCM.39.11.4066-4075.2001)
- Williams, D. W. et al. 2001. Strain persistence of invasive Candida albicans in chronic hyperplastic candidosis that underwent malignant change. Gerodontology 18 (2), pp.73-78. (10.1111/j.1741-2358.2001.00073.x)
- Williams, D. W. et al. 2001. Identification of Candida dubliniensis, based on ribosomal DNA sequence analysis. British Journal of Biomedical Science 58 (1), pp.11-16.
- Wilson, M. et al. 2001. A molecular epidemiological study of sequential oral isolates of Candida albicans from terminally ill patients. Journal Of Oral Pathology & Medicine 30 (4), pp.206-212. (10.1034/j.1600-0714.2001.300403.x)
2000
- Bartie, K. L. et al., 2000. Macrorestriction fingerprinting of "Streptococcus milleri" group bacteria by pulsed-field gel electrophoresis. Journal of Clinical Microbiology 38 (6), pp.2141-2149.
- Williams, D. W. and Lewis, M. A. O. 2000. Oral microbiology: isolation and identification of candida from the oral cavity. Oral Diseases 6 (1), pp.3-11. (10.1111/j.1601-0825.2000.tb00314.x)
- Williams, D. W. et al. 2000. Phenotypic characterisation of Candida albicans isolated from chronic hyperplastic candidosis. Journal of Medical Microbiology 49 (2), pp.199-202.
1998
- Williams, D. W. et al. 1998. Immunocytochemical detection of Candida albicans in formalin fixed, paraffin embedded material. Journal of Clinical Pathology 51 (11), pp.857-859. (10.1136/jcp.51.11.857)
- Williams, D. W. et al. 1998. A novel technique for assessment of adherence of Candida albicans to solid surfaces. Journal of Clinical Pathology 51 (5), pp.390-391. (10.1136/jcp.51.5.390)
1997
- Waters, M. G. J. et al. 1997. Adherence of Candida albicans to experimental denture soft lining materials. Journal of Prosthetic Dentistry 77 (3), pp.306-312. (10.1016/S0022-3913(97)70188-4)
- Williams, D. W. et al. 1997. Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa. Journal of Oral Pathology & Medicine 26 (2), pp.83-89. (10.1111/j.1600-0714.1997.tb00026.x)
1996
- Williams, D. W. et al. 1996. Identification of Candida species in formalin fixed, paraffin wax embedded oral mucosa by sequencing of ribosomal DNA. Clinical Molecular Pathology 49 , pp.M23-M28. (10.1136/mp.49.1.M23)
1995
- Williams, D. W. et al. 1995. Identification of Candida species by PCR and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal DNA. Journal of Clinical Microbiology 33 (9), pp.2476-2479.
1994
- Nicholas, R. O. , Williams, D. W. and Hunter, P. A. 1994. Investigation of the value of β-glucan-specific fluorochromes for predicting the β-glucan content of the cell walls of zoopathogenic fungi. Mycological Research 98 (6), pp.694-698. (10.1016/S0953-7562(09)80419-X)
- Patel, P. D. and Williams, D. W. 1994. Evaluation of commercial kits and instruments for the detection of foodborne pathogens and toxins. In: Patel, P. ed. Rapid Analysis Techniques in Food Microbiology. London: Blackie Academic & Professional. , pp.61-103.
1993
- Patel, P. D. , Williams, D. W. and Haines, S. D. 1993. Rapid separation and detection of foodborne yeasts and moulds by means of lectins. In: Kroll, R. G. , Gilmour, A. and Sussman, M. eds. New Techniques in Food and Beverage Microbiology. Technical series (Society for Applied Bacteriology) Vol. 31.Oxford: Blackwell Scientific Publications. , pp.31-42.
Articles
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- Williams, D. W. et al. 1995. Identification of Candida species by PCR and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal DNA. Journal of Clinical Microbiology 33 (9), pp.2476-2479.
- Williams, D. W. et al. 1996. Identification of Candida species in formalin fixed, paraffin wax embedded oral mucosa by sequencing of ribosomal DNA. Clinical Molecular Pathology 49 , pp.M23-M28. (10.1136/mp.49.1.M23)
- Williams, D. W. et al. 2000. Phenotypic characterisation of Candida albicans isolated from chronic hyperplastic candidosis. Journal of Medical Microbiology 49 (2), pp.199-202.
- Wilson, M. et al. 2001. A molecular epidemiological study of sequential oral isolates of Candida albicans from terminally ill patients. Journal Of Oral Pathology & Medicine 30 (4), pp.206-212. (10.1034/j.1600-0714.2001.300403.x)
- Wise, M. P. et al. 2008. Efficacy of oral chlorhexidine in critical care [Letter]. Critical Care 12 (3)(10.1186/cc6886)
- Wise, M. P. et al. 2008. Impact of poor dental health on pneumonia. European Respiratory Journal 32 (4), pp.1123-1124. (10.1183/09031936.00096808)
- Wise, M. P. et al. 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key?. Critical care (London, England) 14 (4) 181. (10.1186/cc9084)
- Ximenes Lins, R. et al., 2013. Antimicrobial resistance and virulence traits of Enterococcus faecalis from primary endodontic infections. Journal of Dentistry 41 (9), pp.779-786. (10.1016/j.jdent.2013.07.004)
- Xu, R. et al., 2015. IL-34 suppresses 'Candida albicans' induced TNFα production in M1 macrophages by downregulating expression of Dectin-1 and TLR2. Journal of Immunology Research 2015 328146. (10.1155/2015/328146)
- Yanagisawa, M. et al., 2006. Proteinase Activity of Prevotella Species Associated with Oral Purulent Infection. Current Microbiology 52 (5), pp.375-378. (10.1007/s00284-005-0261-1)
- Yee Lim, S. et al., 2020. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International Journal of Pharmaceutics 573 118860. (10.1016/j.ijpharm.2019.118860)
- Zheng, X. F. et al., 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8 (5) e63967. (10.1371/journal.pone.0063967)
Book sections
- Kuriyama, T. , Lewis, M. A. O. and Williams, D. W. 2010. Infections of the oral and maxillofacial region. In: Andersson, L. , Kahnberg, K. and Pogrel, M. A. eds. Oral and Maxillofacial Surgery. Chichester: Wiley. , pp.467-582.
- Kuriyama, T. et al., 2025. Bacterial Infections of the oral and maxillofacial region. In: Anderson, L. et al., Oral and Maxillofacial Surgery. Wiley. , pp.401-473. (10.1002/9781119842958.ch4.1)
- Patel, P. D. and Williams, D. W. 1994. Evaluation of commercial kits and instruments for the detection of foodborne pathogens and toxins. In: Patel, P. ed. Rapid Analysis Techniques in Food Microbiology. London: Blackie Academic & Professional. , pp.61-103.
- Patel, P. D. , Williams, D. W. and Haines, S. D. 1993. Rapid separation and detection of foodborne yeasts and moulds by means of lectins. In: Kroll, R. G. , Gilmour, A. and Sussman, M. eds. New Techniques in Food and Beverage Microbiology. Technical series (Society for Applied Bacteriology) Vol. 31.Oxford: Blackwell Scientific Publications. , pp.31-42.
- Percival, S. L. et al., 2011. Introduction to biofilms. In: Percival, S. L. , Kottenbelt, D. C. and Cochrane, C. A. eds. Biofilms and Veterinary Medicine. Springer Series on Biofilms Vol. 6.London: Springer. , pp.41-68. (10.1007/978-3-642-21289-5_2)
- Williams, D. W. , Kuriyama, T. and Lewis, M. A. O. 2025. Oral fungal infections. In: Anderson, L. et al., Oral and Maxillofacial Surgery. Wiley. , pp.474-480. (10.1002/9781119842958.ch4.2)
- Williams, D. W. , Kuriyama, T. and Lewis, M. A. O. 2025. Orofacial viral infections. In: Anderson, L. , Odont, D. and Krishnan, D. G. eds. Oral and Maxillofacial Surgery. Wiley. , pp.481-490. (10.1002/9781119842958.ch4.3)
Books
- Marsh, P. D. et al., 2009. Oral microbiology. 5th ed.. London: Churchill Livingstone.
- Percival, S. L. et al., 2013. Microbiology of waterborne diseases: microbiological aspects and risks. London: Elsevier.
Conferences
- Marino, P. et al. 2011. Effects of oral microbes on biofilm formation by respiratory pathogens. Presented at: 2011 IADR/AADR/CADR General Session San Diego, CA, USA 19 March 2011.
Research
My research interests primarily focus in the fields of oral microbiology and microbial biofilms. Previous research has been directed towards elucidating the role of Candida in chronic hyperplastic candidosis (CHC), which led to the development of novel genotypic methods for identifying Candida species in fixed tissues. The significance of this work was recognised through receipt of both the Colgate Prize and the IADR/Unilever Hatton Award. Additional Candida research has included the study of antifungal susceptibility of Candida species, virulence gene expression and real-time PCR detection of Candida in oral samples. I have also investigated interaction of Candida with associated bacteria in oral tissue and on medical devices (e.g. silicone rubber, acrylic, and titanium). The invasive properties of Candida based on in vitro tissue models has successfully revealed strain and species variation which could have significance in disease progression. Research in this area has benefited through collaboration with colleagues at the University of Minho (Braga, Portugal), the Gdansk Institute of Technology (Gdansk, Poland), and the Piracicaba Dental School, University of Campinas (Piracicaba, Brazil). have also been involved in studies aimed at elucidating the innate immune response to Candida through cytokine signalling, T-cell differentiation and immune cell infiltration of infected tissues.
Additional biofilm research projects have included the study of endotracheal tube biofilms and their role in ventilator-associated pneumonia, a leading cause of mortality in intensive care units. This work was initiated through close collaboration with Professor J Thomas (University of West Virginia, USA) and in close collaboration with colleagues in the ICU of the University Hospital of Wales.
Urinary tract catheter biofilms are a leading cause of healthcare associated infection and with industrial collaboration together with colleagues at the Bristol Urological Institute we have developed medical devices to aid in the management of these infections.
Chronic wounds are those that do not heal within an expected time-frame and represent a significant cause of patient morbidity and increased healthcare costs. One potential factor involved in delayed wound healing is the presence of microbial biofilms within the wound which are often recalcitrant to antibiotic therapy. Our research has not only characterised these biofilms through culture and molecular analysis but also focused on mechanisms to rapidly detect pathogenic bacterial biofilms within the tissue.
Current Research Projects:
1. Interkingdom relationships in oral biofilms
2. The role of the oral microflora in promoting pneumonia in artificially ventilated patients
3. Novel treatments to combat endodontic biofilms
4. Evaluation of new antibiotics to combat antimicrobial resistance
5. Evaluation of extracellular polymeric substances in biofilms and impact of its removal for the biofilm
6. Effect of biofilms on host immune responses
Teaching
I teach a variety of subjects associated with Oral Microbiology for the dental undergraduate BDS course and for additional postgraduate courses including the Masters in Oral Biology for which I am a module lead. My teaching responsibilities comprise lectures, seminars, practical classes and student assessment. I am a full member of the The Higher Education Academy and a member of the Association of Basic Science Teachers in Dentistry (ABSTD). In terms of external teaching contributions I examine for PhD, MPhil, and MSc students and I am currently an external examiner for the University of Birmingham.
Biography
Career Profile
| 2013-Present | Professor of Oral Microbiology | (Cardiff University) |
| 2007- 2013 | Reader in Oral Microbiology | (Cardiff University) |
| 2003-2007 | Lecturer in Oral Microbiology | (UWCM) |
| 1999-2003 | Lecturer in Oral Microbiology | (UWCM) |
| 1997-1999 | Postdoctoral Research Fellow | (UWCM) |
| 1994 | Diploma in Biomedical Methods (with Distinction) | (UWCM) |
| 1993-1996 | MRC PhD Studentship | (UWCM) |
| 1987-1993 | Research Officer | (Leatherhead Food Research Association) |
| 1983-1987 | BSc (Hons.) Applied Biology (First Class) | (UWCC) |
Teaching Profile
I teach a variety of subjects associated with Oral Microbiology for the dental undergraduate course and for additional postgraduate courses. My teaching responsibilities comprise lectures, seminars, practical classes and student assessment. I am a full member of the The Higher Education Academy and a member of the Association of Basic Science Teachers in Dentistry (ABSTD).
External Assessment
Past and current - School of Clinical Dentistry, Sheffield University (2014-2018; Integrated Human Diseases), King’s College London (2014-19; BDS mid-phase I), Trinity College Dublin (2018-2021) and the University of Birmingham (2019-present).
Honours and awards
Personal awards:
Senior Colgate Prize (1996, BSDR)
Edward H Hatton Award (1997, IADR)
Associated Undergraduate/Postgraduate/Postdoctoral Awards:
Franklyn Williams Elective 2004
PPP Foundation Poster Competition (3rd prize; 2002)
Dental Protection Society Premiere Award (2nd prize; 2002)
Dentsply Student Clinician Award (2002)
Graduate School in Biomedical and Life Sciences Travel Grant (2006)
Bristol Urological Institute Prize Innovation (2009)
The Simon Foundation (2011) Poster Prize Award
Professional memberships
International Association of Dental Research (IADR)
British Society of Oral and Dental Research (BSODR), and previously Honorary Secretary
British Society of Medical Mycology (BSMM)
Association of Basic Science Teachers in Dentistry (ABSTD)
Association of Clinical Oral Microbiologists (ACOM)
The Higher Education Academy
Cardiff Institute of Tissue Engineering and Repair (CITER)
Oral Microbiology and Immunology Group (OMIG), and committee member (2011-present)
Oral Medicine and Pathology Group (OMPG)
Academic positions
1. Reader in Oral Microbiology 2007-2013, School of Dentistry, Cardiff University.
2. Senior lecturer in Oral Microbiology 2003-2007, Cardiff University.
3. Lecturer in Oral Microbiolgy 1999-2003, Cardiff University.
Committees and reviewing
Editorial board member of the Journal of Oral Microbiology
Editorial board member Pathogens
Editorial board member of Biofilms (specialty section of Frontiers in Cellular and Infection Microbiology)
Grant Reviewer, MRC, BBSRC, NBIC
Supervisions
I am interested in supervising PhD students in the areas of:
- Biofilm development
- Oral infection
- Antimicrobial resistance