![Julie Wych BSc (Hons), MSc, PhD](https://profiles-cardiff.imgix.net/attachments/3684?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
Ymunais â'r Ganolfan Ymchwil Treialon yn 2020 fel Cydymaith Ymchwil mewn Ystadegau. Mae gen i brofiad o ymchwil treialon clinigol mewn clefyd cardiofasgwlaidd, canser a diabetes Math 1. Ar hyn o bryd rwy'n gweithio ym mhartneriaeth fyd-eang INNODIA, lle fi yw'r ystadegydd treial ar gyfer MELD-ATG a Ver-A-T1D, nod y treialon ymyrraeth glinigol hyn a gynhelir o fewn INNODIA, yw atal y dirywiad pellach mewn swyddogaethau celloedd beta mewn pobl â T1D sydd newydd gael diagnosis, gan fynd i'r afael â'r system imiwnedd neu'r celloedd beta trwy wahanol ddulliau triniaeth.
Cyhoeddiad
2024
- Wych, J. et al. 2024. Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. BMJ Open 14(11), article number: e091597. (10.1136/bmjopen-2024-091597)
2023
- Othman, J. et al. 2023. A randomised comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial. Blood Advances 7(16), pp. 4539-4549. (10.1182/bloodadvances.2023010276)
2021
- Jayson, G. et al. 2021. VALTIVE1: Validation of Tie2 as a response biomarker for VEGF inhibitors In Ovarian Cancer. Presented at: NCRI Cancer Conference, 2021.
2019
- Wych, J., Grayling, M. J. and Mander, A. P. 2019. Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study. Trials 20(1), article number: 665. (10.1186/s13063-019-3724-6)
- Stather, P. W., Wych, J. and Boyle, J. R. 2019. A systematic review and meta-analysis of remote ischemic preconditioning for vascular surgery. Journal of Vascular Surgery 70(4), pp. 1353-1363. (10.1016/j.jvs.2019.03.025)
2018
- Mukhtar, O. et al. 2018. A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial. American Heart Journal 204, pp. 102-108. (10.1016/j.ahj.2018.05.006)
Articles
- Wych, J. et al. 2024. Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. BMJ Open 14(11), article number: e091597. (10.1136/bmjopen-2024-091597)
- Othman, J. et al. 2023. A randomised comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial. Blood Advances 7(16), pp. 4539-4549. (10.1182/bloodadvances.2023010276)
- Wych, J., Grayling, M. J. and Mander, A. P. 2019. Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study. Trials 20(1), article number: 665. (10.1186/s13063-019-3724-6)
- Stather, P. W., Wych, J. and Boyle, J. R. 2019. A systematic review and meta-analysis of remote ischemic preconditioning for vascular surgery. Journal of Vascular Surgery 70(4), pp. 1353-1363. (10.1016/j.jvs.2019.03.025)
- Mukhtar, O. et al. 2018. A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial. American Heart Journal 204, pp. 102-108. (10.1016/j.ahj.2018.05.006)
Conferences
- Jayson, G. et al. 2021. VALTIVE1: Validation of Tie2 as a response biomarker for VEGF inhibitors In Ovarian Cancer. Presented at: NCRI Cancer Conference, 2021.
Ymchwil
Mae gen i brofiad o weithio mewn treialon ar hap grŵp cyfochrog, traws-dros-dro a chlwstwr, yn ogystal â materion ystadegol sy'n ymwneud â chyfrifiadau maint sampl mewn treialon clinigol. Mae gen i ddiddordeb mewn ystadegau treial, adrodd awtomataidd yn ogystal â threialu methodoleg,
Bywgraffiad
ADDYSG A CHYMWYSTERAU
- MSc Ystadegau Meddygol - Ysgol Hylendid a Meddygaeth Drofannol Llundain (2014)
- PhD Hydroleg - Coleg y Brenin, Llundain (2003)
- BSc Daearyddiaeth - Coleg y Brenin, Llundain (1995)
TROSOLWG GYRFA
- Canolfan Ymchwil Treialon Prifysgol Caerdydd, Caerdydd, y DU (Mehefin 2020 - presennol): Cyswllt Ymchwil - Ystadegau
- Uned Bioystadegau MRC, Ysgol Meddygaeth Glinigol Prifysgol Caergrawnt, Caergrawnt, y DU (2015 – 2020): Ystadegydd Ymchwilydd
- Uned Cardiofasgwlaidd ac Epidemioleg, Adran Iechyd y Cyhoedd a Gofal Sylfaenol, Prifysgol Caergrawnt, Caergrawnt, DU (2014 – 2015): Cydymaith Ymchwil
- Adran Daearyddiaeth, Coleg y Brenin, Llundain, DU (2000 – 2002): Darlithydd mewn Daearyddiaeth Ffisegol
- Adran Daearyddiaeth, Coleg y Brenin, Llundain, DU (1995 – 1999): Cynorthwy-ydd Ymchwil
Anrhydeddau a dyfarniadau
- Gwobr Cydnabyddiaeth Arbennig MRC i gydnabod cyfraniad eithriadol i waith Uned Bioystadegau'r Cyngor Ymchwil (Ebrill, 2019)
Safleoedd academaidd blaenorol
- Canolfan Ymchwil Treialon Prifysgol Caerdydd, Caerdydd, y DU (Mehefin 2020 - presennol): Cyswllt Ymchwil - Ystadegau
- Uned Bioystadegau MRC, Ysgol Meddygaeth Glinigol Prifysgol Caergrawnt, Caergrawnt, y DU (2015 – 2020): Ystadegydd Ymchwilydd
- Uned Cardiofasgwlaidd ac Epidemioleg, Adran Iechyd y Cyhoedd a Gofal Sylfaenol, Prifysgol Caergrawnt, Caergrawnt, DU (2014 – 2015): Cydymaith Ymchwil
- Adran Daearyddiaeth, Coleg y Brenin, Llundain, DU (2000 – 2002): Darlithydd mewn Daearyddiaeth Ffisegol
- Adran Daearyddiaeth, Coleg y Brenin, Llundain, DU (1995 – 1999): Cynorthwy-ydd Ymchwil
Contact Details
Themâu ymchwil
Arbenigeddau
- Biostatistics
- Treialon clinigol
- Modelu ac efelychu