![Julie Wych BSc (Hons), MSc, PhD](https://profiles-cardiff.imgix.net/attachments/3684?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
I joined the Centre for Trials Research in 2020 as a Research Associate in Statistics. I have experience of clinical trial research in cardiovascular disease, cancer and Type 1 diabetes. I currently work in the INNODIA global partnership, where I am the trial statistician for MELD-ATG and Ver-A-T1D, the goal of these clinical intervention trials conducted within INNODIA, is to halt the further decline in beta cell functionality in people with newly diagnosed T1D, addressing the immune system or the beta cells by different treatment modalities.
Publication
2024
- Wych, J. et al. 2024. Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. BMJ Open 14(11), article number: e091597. (10.1136/bmjopen-2024-091597)
2023
- Othman, J. et al. 2023. A randomised comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial. Blood Advances 7(16), pp. 4539-4549. (10.1182/bloodadvances.2023010276)
2021
- Jayson, G. et al. 2021. VALTIVE1: Validation of Tie2 as a response biomarker for VEGF inhibitors In Ovarian Cancer. Presented at: NCRI Cancer Conference, 2021.
2019
- Wych, J., Grayling, M. J. and Mander, A. P. 2019. Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study. Trials 20(1), article number: 665. (10.1186/s13063-019-3724-6)
- Stather, P. W., Wych, J. and Boyle, J. R. 2019. A systematic review and meta-analysis of remote ischemic preconditioning for vascular surgery. Journal of Vascular Surgery 70(4), pp. 1353-1363. (10.1016/j.jvs.2019.03.025)
2018
- Mukhtar, O. et al. 2018. A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial. American Heart Journal 204, pp. 102-108. (10.1016/j.ahj.2018.05.006)
Articles
- Wych, J. et al. 2024. Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. BMJ Open 14(11), article number: e091597. (10.1136/bmjopen-2024-091597)
- Othman, J. et al. 2023. A randomised comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial. Blood Advances 7(16), pp. 4539-4549. (10.1182/bloodadvances.2023010276)
- Wych, J., Grayling, M. J. and Mander, A. P. 2019. Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study. Trials 20(1), article number: 665. (10.1186/s13063-019-3724-6)
- Stather, P. W., Wych, J. and Boyle, J. R. 2019. A systematic review and meta-analysis of remote ischemic preconditioning for vascular surgery. Journal of Vascular Surgery 70(4), pp. 1353-1363. (10.1016/j.jvs.2019.03.025)
- Mukhtar, O. et al. 2018. A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial. American Heart Journal 204, pp. 102-108. (10.1016/j.ahj.2018.05.006)
Conferences
- Jayson, G. et al. 2021. VALTIVE1: Validation of Tie2 as a response biomarker for VEGF inhibitors In Ovarian Cancer. Presented at: NCRI Cancer Conference, 2021.
Research
I have experience of working in parallel group, crossover and cluster randomised trials as well as statistical issues involving sample size calculations in clinical trials. I am interested in trial statistics, automated reporting as well as trials methodology,
Biography
EDUCATION AND QUALIFICATIONS
- MSc Medical Statistics - London School of Hygiene and Tropical Medicine (2014)
- PhD Hydrology - King’s College, London (2003)
- BSc Geography - King’s College, London (1995)
CAREER OVERVIEW
- Cardiff University’s Centre for Trials Research, Cardiff, UK (June 2020 - present): Research Associate - Statistics
- MRC Biostatistics Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK (2015 – 2020): Investigator Statistician
- Cardiovascular and Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (2014 – 2015): Research Associate
- Department of Geography, King’s College, London, UK (2000 – 2002): Lecturer in Physical Geography
- Department of Geography, King’s College, London, UK (1995 – 1999): Research Assistant
Honours and awards
- MRC Special Recognition Award in recognition for outstanding contribution to the MRC Biostatistics Unit’s work (April, 2019)
Academic positions
- Cardiff University’s Centre for Trials Research, Cardiff, UK (June 2020 - present): Research Associate - Statistics
- MRC Biostatistics Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK (2015 – 2020): Investigator Statistician
- Cardiovascular and Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (2014 – 2015): Research Associate
- Department of Geography, King’s College, London, UK (2000 – 2002): Lecturer in Physical Geography
- Department of Geography, King’s College, London, UK (1995 – 1999): Research Assistant
Contact Details
Research themes
Specialisms
- Biostatistics
- clinical trials
- Modelling and simulation