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Dr Jack Underwood Underwood
Wellcome Trust GW4-CAT Clinical Research Fellow, NMHRI
Overview
I am a Forensic Psychiatry Registrar on the Wales Clinical Academic Track, currently doing a PhD on a Wellcome Trust GW4-CAT Fellowship. My work looks at why co-occurring mental health conditions occur more frequently in Autism Spectrum Disorder using genetic and epidemiological techniques.
Publication
2023
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Levy, R., Timothy, K., Underwood, J., Hall, J., Bernstein, J. and Pasca, S. 2023. A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder. Pediatric Neurology 138, pp. 101-106. (10.1016/j.pediatrneurol.2022.10.013)
2022
- Wren, G. et al. 2022. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics (10.1136/jmg-2022-108862)
- Underwood, J., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. and Hall, J. 2022. Neurological and psychiatric disorders among autistic adults: a population healthcare record study. Psychological Medicine (10.1017/S0033291722002884)
- Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., John, A. and Hall, J. 2022. Evidence of increasing recorded diagnosis of autism spectrum disorders in Wales, UK – an e-cohort study. Autism 26(6), pp. 1499-1508. (10.1177/13623613211059674)
- Brcic, L., Wren, G., Underwood, J., Kirov, G. and Davies, W. 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2(3), article number: 100109. (10.1016/j.xjidi.2022.100109)
2021
- Hoskins, M. D. et al. 2021. Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches. European Journal of Psychotraumatology 12(1), article number: 1802920. (10.1080/20008198.2020.1802920)
- Hoskins, M. D. et al. 2021. Pharmacological-assisted psychotherapy for post-traumatic stress disorder: a systematic review and meta-analysis. European Journal of Psychotraumatology 12(1), article number: 1853379. (10.1080/20008198.2020.1853379)
2020
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
2019
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
2017
- Black, L. F. and Underwood, J. F. G. 2017. P.3.b.045 - Psychosis in Wilson’s disease: an unusual presentation of bipolar affective disorder. Presented at: 30th ECNP Congress 2017, Paris, France, 2-5 September 2017, Vol. 27. Vol. Supple. Elsevier pp. S915., (10.1016/S0924-977X(17)31627-9)
Articles
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Levy, R., Timothy, K., Underwood, J., Hall, J., Bernstein, J. and Pasca, S. 2023. A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder. Pediatric Neurology 138, pp. 101-106. (10.1016/j.pediatrneurol.2022.10.013)
- Wren, G. et al. 2022. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics (10.1136/jmg-2022-108862)
- Underwood, J., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. and Hall, J. 2022. Neurological and psychiatric disorders among autistic adults: a population healthcare record study. Psychological Medicine (10.1017/S0033291722002884)
- Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., John, A. and Hall, J. 2022. Evidence of increasing recorded diagnosis of autism spectrum disorders in Wales, UK – an e-cohort study. Autism 26(6), pp. 1499-1508. (10.1177/13623613211059674)
- Brcic, L., Wren, G., Underwood, J., Kirov, G. and Davies, W. 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2(3), article number: 100109. (10.1016/j.xjidi.2022.100109)
- Hoskins, M. D. et al. 2021. Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches. European Journal of Psychotraumatology 12(1), article number: 1802920. (10.1080/20008198.2020.1802920)
- Hoskins, M. D. et al. 2021. Pharmacological-assisted psychotherapy for post-traumatic stress disorder: a systematic review and meta-analysis. European Journal of Psychotraumatology 12(1), article number: 1853379. (10.1080/20008198.2020.1853379)
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
Conferences
- Black, L. F. and Underwood, J. F. G. 2017. P.3.b.045 - Psychosis in Wilson’s disease: an unusual presentation of bipolar affective disorder. Presented at: 30th ECNP Congress 2017, Paris, France, 2-5 September 2017, Vol. 27. Vol. Supple. Elsevier pp. S915., (10.1016/S0924-977X(17)31627-9)
Research
Autism Spectrum Disorder (autism) is a long-term condition which affects 1-2% of people. People with autism can have difficulties with social skills and communicating with other people, repetitive behaviour and can have a small range of hobbies or interests. It can affect how people perceive the world. Some autistic people see, hear and feel the world differently. More autistic people are being identified, as people become more aware of the condition. Mental health problems are more common in autistic people, but we don't understand why. My work looks at this, and what effects genetics or lifestyle have. My work examines the effects of copy number variants (CNVs) and polygenic risk (PGS) alongside hospital and general practice record data on chances of mental health outcomes, using a group of people with autism taken from the National Centre for Mental Health (NCMH) Database, as well as people with autism from two large datasets of anonymised health records.
Teaching
I teach psychiatry on the Cardiff University Medicine MBBCh course, including small group teaching on personality disorders and communication skills. I am a formative and summative psychiatry ISCE examiner. I supervise intercalating student projects on the Psychology in Medicine course. I am also a Neuroscience Trainee Editor for the Royal College of Psychiatrists TrOn modules, and an RCPsych Neuroscience Champion for Wales.
Biography
I am a Forensic Psychiatry Registrar on the Wales Clinical Academic Track, currently OOP doing a PhD on a Wellcome Trust GW4-CAT Fellowship. I undertook Core Psychiatry Training and the Foundation Programme in South Wales, after graduating from Medicine (BMBS) at Peninsula College of Medicine and Dentistry. I have been a member of the Royal College of Psychiatrists since 2018.
Honours and awards
2019 – Wellcome Trust GW4-CAT Clinical Academic Training Fellowship
2018 – Wellcome Trust ISSF Clinical Primer Award
2018 – RCPsych International Congress Travel Bursary
2018 – European Psychiatric Association Congress Travel Grant
2017 – BEST Trainee Awards 2017 – Teaching (Nominee)
2016 – Cardiff MRC Centre Clinical Academic Mentorship Scheme
Professional memberships
Member of the Royal College of Psychiatrists (MRCPsych)
Registered with the General Medical Council (7414226)
Committees and reviewing
Peer review activity – BJPsych Bulletin, BJPsych Open, Research in Developmental Disorders.
Wellcome Gatsby Neuroscience – as Neuroscience Trainee Editor for TrOn and Neuroscience Champion for Wales.
Supervisors
Professor Jeremy Hall
Director of Division of Psychiatry and Clinical Neuroscience, Director of Neuroscience and Mental Health Innovation Institute, Hon. Consultant Psychiatrist.
Dr Richard Anney
Senior Lecturer in Bioinformatics, Division of Psychological Medicine and Clinical Neurosciences