![Angelo Amoroso](https://profiles-cardiff.imgix.net/attachments/1463?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Angelo Amoroso
(he/him)
Senior Lecturer in Inorganic Chemistry and Director of Learning and Teaching
- Available for postgraduate supervision
Overview
Recently we have been interested in developing new imaging agents as research tools for stem cell implants providing an ability to visualise, monitor and track the fate of the transplanted cells directly in vivo.
In the course of this research the design, synthesis and investigation of the properties of a range of new ligands will be carried out, with properties such as enhanced stability, bio-orthogonal reactivity and electrochemical/photophysical properties being of interest.
For more information, click on the 'Research' tab above.
Publication
2022
- Al-Riyahee, A. A., Horton, P. N., Coles, S. J., Amoroso, A. J. and Pope, S. J. A. 2022. Ni(II), Cu(II) and Zn(II) complexes of functionalised thiosemicarbazone ligands: Syntheses and reactivity, characterization and structural studies. Polyhedron 225, article number: 116079. (10.1016/j.poly.2022.116079)
- Al-Riyahee, A. A. A., Horton, P. N., Coles, S. J., Berry, C., Horrocks, P. D., Pope, S. J. A. and Amoroso, A. J. 2022. N,N′-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties. Dalton Transactions 51(9), pp. 3531-3545. (10.1039/D1DT04091J)
2019
- Al-Riyahee, A. A., Horton, P. N., Coles, S. J., Amoroso, A. J. and Pope, S. J. 2019. Syntheses, X-ray structures and characterisation of luminescent chromium(III) complexes incorporating 8-quinolinato ligands. Polyhedron 157, pp. 396. (10.1016/j.poly.2018.10.019)
2017
- Sathiyajith, C., Hallett, A. J., Amoroso, A. J. and Edwards, P. G. 2017. Dual modal imaging agents based on chromophore-bearing DTPA analogues. RSC Advances 7(61), pp. 38463-38470. (10.1039/C7RA06946D)
- Amoroso, A. J., Fallis, I. A. and Pope, S. J. A. 2017. Chelating agents for radiolanthanides: applications to imaging and therapy. Coordination Chemistry Reviews 340, pp. 198-219. (10.1016/j.ccr.2017.01.010)
2016
- Amoroso, A. J., Knight, J. C., Edwards, P. G., Singh, N. and Ward, B. D. 2016. Shaping and enforcing coordination spheres: probing the ability of tripodal ligands to favour trigonal prismatic geometry. Dalton Transactions 45(26), pp. 10630-10642. (10.1039/C6DT01165A)
- Amoroso, A. J., Saad, F., Knight, J. C. and Kariuki, B. 2016. Co-ordination behaviour of a novel tristhiourea tripodal ligand; structural variations in a series of transition metal complexes. Dalton Transactions 45(25), pp. 10280-10288. (10.1039/C6DT01148A)
- Jana, A. et al. 2016. Heteronuclear Ir(III)–Ln(III) luminescent complexes: small-molecule probes for dual modal imaging and oxygen sensing. Inorganic Chemistry 55(11), pp. 5623-5633. (10.1021/acs.inorgchem.6b00702)
- Stacey, O. J., Ward, B. D., Amoroso, A. J. and Pope, S. J. A. 2016. Near-IR luminescent lanthanide complexes with 1,8-diaminoanthraquinone-based chromophoric ligands. Dalton Transactions 45(15), pp. 6674-6681. (10.1039/C5DT04351D)
2015
- Stacey, O. J. et al. 2015. Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents. Chemical Communications 51(61), pp. 12305-12308. (10.1039/C5CC02623G)
- Amoroso, A. J. and Pope, S. J. A. 2015. Using lanthanide ions in molecular bioimaging. Chemical Society Reviews 44(14), pp. 4723-4742. (10.1039/C4CS00293H)
- Jana, A., Baggaley, E., Amoroso, A. and Ward, M. D. 2015. A new ligand skeleton for imaging applications with d–f complexes: combined lifetime imaging and high relaxivity in an Ir/Gd dyad. Chemical Communications 51(42), pp. 8833-8836. (10.1039/C5CC02130H)
2014
- Foerster, C. et al. 2014. [64Cu]Cu-CryptTM – A novel cryptate for copper-64?. Nuclear Medicine and Biology 41(7), pp. 633. (10.1016/j.nucmedbio.2014.05.127)
- Foerster, C. et al. 2014. Synthesis, complex stability and small animal PET imaging of a novel 64Cu-labelled cryptand molecule. MedChemComm 5(7), pp. 958-962. (10.1039/c4md00174e)
- Hossain, G. M. G. and Amoroso, A. J. 2014. Bis[4-amino-N-(4-methylpyrimidin-2-yl-[kappa]N3)benzenesulfonamidato-[kappa]N](2,2'-bipyridine-[kappa]2N,N')mercury(II). Acta Crystallographica Section E - Structure Reports Online 70(4), pp. m127-m128. (10.1107/S1600536814004760)
2013
- Knight, J. C. et al. 2013. Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions. Dalton Transactions 42(33), pp. 12005-12014. (10.1039/c3dt50960e)
- Saad, F. A., Knight, J. C., Kariuki, B. and Amoroso, A. J. 2013. Co-ordinative properties of a tripodal trisamide ligand with a capped octahedral preference. Dalton Transactions 42(41), pp. 14826-14835. (10.1039/c3dt51791h)
- Knight, J. C. et al. 2013. Synthesis, characterisation and radiopharmacological evaluation of a novel copper-64 complex derived from a tripodal N4S ligand [Poster presentation]. Journal of Labelled Compounds and Radiopharmaceuticals 56(S1), pp. S213.
2012
- Hossain, G. M. G. and Amoroso, A. J. 2012. Bis[4-amino-N-(pyrimidin-2-yl-kappaN)benzenesulfonamidato-kappaN](4,4'-dimethyl-2,2'-bipyridine-kappa2N,N')cadmium dimethylformamide disolvate. Acta Crystallographica Section E Structure Reports Online 68(3), pp. m276-m277. (10.1107/S1600536812004412)
- Saad, F., Buurma, N. J., Amoroso, A. J., Knight, J. C. and Kariuki, B. . 2012. Co-ordination behaviour of a novel bisthiourea tripodal ligand: structural, spectroscopic and electrochemical properties of a series of transition metal complexes. Dalton Transactions 41(15), pp. 4608-4617. (10.1039/c2dt11732k)
2011
- Knight, J. C., Prabaharan, R., Amoroso, A. J., Edwards, P. G. and Ooi, L. 2011. Synthesis and co-ordination chemistry of tris(picolyl-2-carboxyamido-6-pyridyl) methanol: A ligand with a strong preference for trigonal prismatic geometries. Polyhedron 31(1), pp. 457-462. (10.1016/j.poly.2011.09.040)
- Jones, J. E., Amoroso, A. J., Dorin, I. M., Parigi, G., Ward, B. D., Buurma, N. J. and Pope, S. J. A. 2011. Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity. Chemical Communications 47(12), pp. 3374-3376. (10.1039/C1CC00111F)
- Knight, J. C., Prabaharan, R., Edwards, P. G. and Amoroso, A. J. 2011. Co-ordination of a new bis-terpyridine ligand with cupric perchlorate yielding a dinuclear M2L species. Journal of Molecular Structure 989(1-3), pp. 86-90. (10.1016/j.molstruc.2011.01.009)
2010
- Knight, J. C., Amoroso, A. J., Edwards, P. G., Prabaharan, R. and Singh, N. 2010. The co-ordination chemistry of bis(2,2′-bipyrid-6′-yl)ketone with first row transition metals: the reversible interconversion of a mononuclear complex and a dinuclear hemiketal containing species. Dalton Transactions 39(38), pp. 8925-8936. (10.1039/c0dt00344a)
- Knight, J. C., Prabaharan, R., Ward, B. D., Amoroso, A. J., Edwards, P. G. and Kariuki, B. 2010. A facile one-pot synthesis of a new cryptand via a Pd(II)-catalysed carbonylation reaction. Dalton Transactions 39(42), pp. 10031-10033. (10.1039/C0DT01205J)
- Andrews, M., Amoroso, A. J., Harding, L. P. and Pope, S. J. A. 2010. Responsive, di-metallic lanthanide complexes of a piperazine-bridged bis-macrocyclic ligand: modulation of visible luminescence and proton relaxivity. Dalton Transactions 39(14), pp. 3407-3411. (10.1039/b923988j)
- Amoroso, A. J., Banu, A., Coogan, M. P., Edwards, P. G., Hossain, G. and Malik, K. M. A. 2010. Functionalisation of terpyridine complexes containing the Re(CO)3+ moiety. Dalton Transactions 39(30), pp. 6993-7003. (10.1039/c0dt00174k)
- Knight, J. C., Alvarez, S., Amoroso, A. J., Edwards, P. G. and Singh, N. 2010. A novel bipyridine-based hexadentate tripodal framework with a strong preference for trigonal prismatic co-ordination geometries. Dalton Transactions 39(16), pp. 3870-3883. (10.1039/b924651g)
- Fernández-Moreira, V. et al. 2010. Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Organic and Biomolecular Chemistry 8(17), pp. 3888-3901. (10.1039/c004610h)
2009
- Amoroso, A. J. et al. 2009. The synthesis and coordination chemistry of a tris-8-aminoquinoline tripodal ligand. Dalton Transactions(39), pp. 8356-8362. (10.1039/b909122j)
- Echeverria, J., Cremades, E., Amoroso, A. J. and Alvarez, S. 2009. Jahn-Teller distortions of six-coordinate CuII compounds: cis or trans?. Chemical Communications 2009(28), pp. 4242-4244. (10.1039/b903867a)
- Knight, J. C., Saad, F., Amoroso, A. J., Kariuki, B. and Coles, S. J. 2009. rac-N-{6-[Bromo(hydroxy)methyl]-2-pyridyl}pivalamide. Acta Crystallographica Section E - Structure Reports Online 65(3), article number: O647. (10.1107/S1600536809006795)
2008
- Amoroso, A. J. et al. 2008. 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria. New Journal of Chemistry 32(7), pp. 1097-1102. (10.1039/b802215a)
- Amoroso, A. J. et al. 2008. The synthesis and structure of terpyridine-N-oxide complexes of copper(II) perchlorate. Dalton Transactions(4), pp. 506-513. (10.1039/b713444d)
2007
- Amoroso, A. J. et al. 2007. Rhenium fac tricarbonyl bisimine complexes: biologically useful fluorochromes for cell imaging applications. Chemical Communications(29), pp. 3066-3068. (10.1039/b706657k)
Articles
- Al-Riyahee, A. A., Horton, P. N., Coles, S. J., Amoroso, A. J. and Pope, S. J. A. 2022. Ni(II), Cu(II) and Zn(II) complexes of functionalised thiosemicarbazone ligands: Syntheses and reactivity, characterization and structural studies. Polyhedron 225, article number: 116079. (10.1016/j.poly.2022.116079)
- Al-Riyahee, A. A. A., Horton, P. N., Coles, S. J., Berry, C., Horrocks, P. D., Pope, S. J. A. and Amoroso, A. J. 2022. N,N′-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties. Dalton Transactions 51(9), pp. 3531-3545. (10.1039/D1DT04091J)
- Al-Riyahee, A. A., Horton, P. N., Coles, S. J., Amoroso, A. J. and Pope, S. J. 2019. Syntheses, X-ray structures and characterisation of luminescent chromium(III) complexes incorporating 8-quinolinato ligands. Polyhedron 157, pp. 396. (10.1016/j.poly.2018.10.019)
- Sathiyajith, C., Hallett, A. J., Amoroso, A. J. and Edwards, P. G. 2017. Dual modal imaging agents based on chromophore-bearing DTPA analogues. RSC Advances 7(61), pp. 38463-38470. (10.1039/C7RA06946D)
- Amoroso, A. J., Fallis, I. A. and Pope, S. J. A. 2017. Chelating agents for radiolanthanides: applications to imaging and therapy. Coordination Chemistry Reviews 340, pp. 198-219. (10.1016/j.ccr.2017.01.010)
- Amoroso, A. J., Knight, J. C., Edwards, P. G., Singh, N. and Ward, B. D. 2016. Shaping and enforcing coordination spheres: probing the ability of tripodal ligands to favour trigonal prismatic geometry. Dalton Transactions 45(26), pp. 10630-10642. (10.1039/C6DT01165A)
- Amoroso, A. J., Saad, F., Knight, J. C. and Kariuki, B. 2016. Co-ordination behaviour of a novel tristhiourea tripodal ligand; structural variations in a series of transition metal complexes. Dalton Transactions 45(25), pp. 10280-10288. (10.1039/C6DT01148A)
- Jana, A. et al. 2016. Heteronuclear Ir(III)–Ln(III) luminescent complexes: small-molecule probes for dual modal imaging and oxygen sensing. Inorganic Chemistry 55(11), pp. 5623-5633. (10.1021/acs.inorgchem.6b00702)
- Stacey, O. J., Ward, B. D., Amoroso, A. J. and Pope, S. J. A. 2016. Near-IR luminescent lanthanide complexes with 1,8-diaminoanthraquinone-based chromophoric ligands. Dalton Transactions 45(15), pp. 6674-6681. (10.1039/C5DT04351D)
- Stacey, O. J. et al. 2015. Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents. Chemical Communications 51(61), pp. 12305-12308. (10.1039/C5CC02623G)
- Amoroso, A. J. and Pope, S. J. A. 2015. Using lanthanide ions in molecular bioimaging. Chemical Society Reviews 44(14), pp. 4723-4742. (10.1039/C4CS00293H)
- Jana, A., Baggaley, E., Amoroso, A. and Ward, M. D. 2015. A new ligand skeleton for imaging applications with d–f complexes: combined lifetime imaging and high relaxivity in an Ir/Gd dyad. Chemical Communications 51(42), pp. 8833-8836. (10.1039/C5CC02130H)
- Foerster, C. et al. 2014. [64Cu]Cu-CryptTM – A novel cryptate for copper-64?. Nuclear Medicine and Biology 41(7), pp. 633. (10.1016/j.nucmedbio.2014.05.127)
- Foerster, C. et al. 2014. Synthesis, complex stability and small animal PET imaging of a novel 64Cu-labelled cryptand molecule. MedChemComm 5(7), pp. 958-962. (10.1039/c4md00174e)
- Hossain, G. M. G. and Amoroso, A. J. 2014. Bis[4-amino-N-(4-methylpyrimidin-2-yl-[kappa]N3)benzenesulfonamidato-[kappa]N](2,2'-bipyridine-[kappa]2N,N')mercury(II). Acta Crystallographica Section E - Structure Reports Online 70(4), pp. m127-m128. (10.1107/S1600536814004760)
- Knight, J. C. et al. 2013. Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions. Dalton Transactions 42(33), pp. 12005-12014. (10.1039/c3dt50960e)
- Saad, F. A., Knight, J. C., Kariuki, B. and Amoroso, A. J. 2013. Co-ordinative properties of a tripodal trisamide ligand with a capped octahedral preference. Dalton Transactions 42(41), pp. 14826-14835. (10.1039/c3dt51791h)
- Knight, J. C. et al. 2013. Synthesis, characterisation and radiopharmacological evaluation of a novel copper-64 complex derived from a tripodal N4S ligand [Poster presentation]. Journal of Labelled Compounds and Radiopharmaceuticals 56(S1), pp. S213.
- Hossain, G. M. G. and Amoroso, A. J. 2012. Bis[4-amino-N-(pyrimidin-2-yl-kappaN)benzenesulfonamidato-kappaN](4,4'-dimethyl-2,2'-bipyridine-kappa2N,N')cadmium dimethylformamide disolvate. Acta Crystallographica Section E Structure Reports Online 68(3), pp. m276-m277. (10.1107/S1600536812004412)
- Saad, F., Buurma, N. J., Amoroso, A. J., Knight, J. C. and Kariuki, B. . 2012. Co-ordination behaviour of a novel bisthiourea tripodal ligand: structural, spectroscopic and electrochemical properties of a series of transition metal complexes. Dalton Transactions 41(15), pp. 4608-4617. (10.1039/c2dt11732k)
- Knight, J. C., Prabaharan, R., Amoroso, A. J., Edwards, P. G. and Ooi, L. 2011. Synthesis and co-ordination chemistry of tris(picolyl-2-carboxyamido-6-pyridyl) methanol: A ligand with a strong preference for trigonal prismatic geometries. Polyhedron 31(1), pp. 457-462. (10.1016/j.poly.2011.09.040)
- Jones, J. E., Amoroso, A. J., Dorin, I. M., Parigi, G., Ward, B. D., Buurma, N. J. and Pope, S. J. A. 2011. Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity. Chemical Communications 47(12), pp. 3374-3376. (10.1039/C1CC00111F)
- Knight, J. C., Prabaharan, R., Edwards, P. G. and Amoroso, A. J. 2011. Co-ordination of a new bis-terpyridine ligand with cupric perchlorate yielding a dinuclear M2L species. Journal of Molecular Structure 989(1-3), pp. 86-90. (10.1016/j.molstruc.2011.01.009)
- Knight, J. C., Amoroso, A. J., Edwards, P. G., Prabaharan, R. and Singh, N. 2010. The co-ordination chemistry of bis(2,2′-bipyrid-6′-yl)ketone with first row transition metals: the reversible interconversion of a mononuclear complex and a dinuclear hemiketal containing species. Dalton Transactions 39(38), pp. 8925-8936. (10.1039/c0dt00344a)
- Knight, J. C., Prabaharan, R., Ward, B. D., Amoroso, A. J., Edwards, P. G. and Kariuki, B. 2010. A facile one-pot synthesis of a new cryptand via a Pd(II)-catalysed carbonylation reaction. Dalton Transactions 39(42), pp. 10031-10033. (10.1039/C0DT01205J)
- Andrews, M., Amoroso, A. J., Harding, L. P. and Pope, S. J. A. 2010. Responsive, di-metallic lanthanide complexes of a piperazine-bridged bis-macrocyclic ligand: modulation of visible luminescence and proton relaxivity. Dalton Transactions 39(14), pp. 3407-3411. (10.1039/b923988j)
- Amoroso, A. J., Banu, A., Coogan, M. P., Edwards, P. G., Hossain, G. and Malik, K. M. A. 2010. Functionalisation of terpyridine complexes containing the Re(CO)3+ moiety. Dalton Transactions 39(30), pp. 6993-7003. (10.1039/c0dt00174k)
- Knight, J. C., Alvarez, S., Amoroso, A. J., Edwards, P. G. and Singh, N. 2010. A novel bipyridine-based hexadentate tripodal framework with a strong preference for trigonal prismatic co-ordination geometries. Dalton Transactions 39(16), pp. 3870-3883. (10.1039/b924651g)
- Fernández-Moreira, V. et al. 2010. Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Organic and Biomolecular Chemistry 8(17), pp. 3888-3901. (10.1039/c004610h)
- Amoroso, A. J. et al. 2009. The synthesis and coordination chemistry of a tris-8-aminoquinoline tripodal ligand. Dalton Transactions(39), pp. 8356-8362. (10.1039/b909122j)
- Echeverria, J., Cremades, E., Amoroso, A. J. and Alvarez, S. 2009. Jahn-Teller distortions of six-coordinate CuII compounds: cis or trans?. Chemical Communications 2009(28), pp. 4242-4244. (10.1039/b903867a)
- Knight, J. C., Saad, F., Amoroso, A. J., Kariuki, B. and Coles, S. J. 2009. rac-N-{6-[Bromo(hydroxy)methyl]-2-pyridyl}pivalamide. Acta Crystallographica Section E - Structure Reports Online 65(3), article number: O647. (10.1107/S1600536809006795)
- Amoroso, A. J. et al. 2008. 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria. New Journal of Chemistry 32(7), pp. 1097-1102. (10.1039/b802215a)
- Amoroso, A. J. et al. 2008. The synthesis and structure of terpyridine-N-oxide complexes of copper(II) perchlorate. Dalton Transactions(4), pp. 506-513. (10.1039/b713444d)
- Amoroso, A. J. et al. 2007. Rhenium fac tricarbonyl bisimine complexes: biologically useful fluorochromes for cell imaging applications. Chemical Communications(29), pp. 3066-3068. (10.1039/b706657k)
- Knight, J. C. et al. 2013. Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions. Dalton Transactions 42(33), pp. 12005-12014. (10.1039/c3dt50960e)
- Jones, J. E., Amoroso, A. J., Dorin, I. M., Parigi, G., Ward, B. D., Buurma, N. J. and Pope, S. J. A. 2011. Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity. Chemical Communications 47(12), pp. 3374-3376. (10.1039/C1CC00111F)
- Echeverria, J., Cremades, E., Amoroso, A. J. and Alvarez, S. 2009. Jahn-Teller distortions of six-coordinate CuII compounds: cis or trans?. Chemical Communications 2009(28), pp. 4242-4244. (10.1039/b903867a)
- Amoroso, A. J. et al. 2008. 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria. New Journal of Chemistry 32(7), pp. 1097-1102. (10.1039/b802215a)
Research
- Development of highly fluorescent complexes for as biological tags or as chemical sensors.
- Design and synthesis of ligands suitable for the construction of imaging agents. We are currently synthesising reagents which will show redox/chemical switching behaviour thus producing effective diagnostic reagents.
- Ligand modifications resulting in modified stereochemistry and reactivity. Underlying our applied research is the intriguing topic of how simple changes to a ligand array may greatly affect topology and prehaps reactivity.
Recently we have been interested in developing new imaging agents as research tools for stem cell implants. The use of stem cells for cellular therapies is an area of research which shows great promise for alleviating and potentially repairing a range of conditions. However, a major constraint on research in transplantation is the difficulty to visualise, monitor and track the fate of the transplanted cells directly in vivo. Some progress has been made for tracking a variety of graft types in vivo using PET. In an attempt to develop a new generation of PET agents that may be used for in vivo imaging of tissue repair we have develop methodologies to coordinate and purify complexes of long-lived metal isotopes that allow imaging over prolonged periods, providing new research tools in this area of research.
For more information on specific projects with Dr Angelo Amoroso please review the Molecular synthesis section of our research project themes.
Teaching
CH5202 - Reactivity And Properties Of The Elements And Their Compounds
CH2301 - Training in Research methods
CH4302 - Advanced Organometallic and Coordination Chemistry
CH3403 - Bio-imaging Applications of Coordination Chemistry
Biography
PhD, University of Cambridge (1992, B. F. G. Johnson and J. Lewis, synthesis of high nuclearity osmium carbonyl clusters). Postdoctoral Research Fellow, Bristol (1992-1995, J. A. McCleverty and M. D. Ward, synthesis and properties of Mo(NO) species). Postdoctoral Research Fellow, University of Utah (1995-1997, J. A. Gladysz, synthesis and properties of Re(NO) species linked by polyacetylene fragments). Postdoctoral Research Fellow, University of Nottingham (1997-1998, M. Schröder, modelling Ni/Fe hydrogenases). Appointed Lecturer in Inorganic Chemistry, Cardiff, 1998.
Research themes
Specialisms
- Inorganic chemistry