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Angelo Amoroso

Dr Angelo Amoroso

(he/him)

Senior Lecturer in Inorganic Chemistry and Director of Learning and Teaching

School of Chemistry

Users
Available for postgraduate supervision

Overview

Recently we have been interested in developing new imaging agents as research tools for stem cell implants providing an ability to visualise, monitor and track the fate of the transplanted cells directly in vivo.

In the course of this research the design, synthesis and investigation of the properties of a range of new ligands will be carried out, with properties such as enhanced stability, bio-orthogonal reactivity and electrochemical/photophysical properties being of interest.  

For more information, click on the 'Research' tab above.

Publication

2024

2022

2019

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

Articles

Book sections

Research

  • Development of highly fluorescent complexes for as biological tags or as chemical sensors.
  • Design and synthesis of ligands suitable for the construction of imaging agents. We are currently synthesising reagents which will show redox/chemical switching behaviour thus producing effective diagnostic reagents. 
  • Ligand modifications resulting in modified stereochemistry and reactivity. Underlying our applied research is the intriguing topic of how simple changes to a ligand array may greatly affect topology and prehaps reactivity.

Recently we have been interested in developing new imaging agents as research tools for stem cell implants. The use of stem cells for cellular therapies is an area of research which shows great promise for alleviating and potentially repairing a range of  conditions. However, a major constraint on research in transplantation is the difficulty to visualise, monitor and track the fate of the transplanted cells directly in vivo. Some progress has been made for tracking a variety of graft types in vivo using PET. In an attempt to develop a new generation of PET agents that may be used for in vivo imaging of tissue repair we have develop methodologies to coordinate and purify complexes of long-lived metal isotopes that allow imaging over prolonged periods, providing  new research tools in this area of research. 

For more information on specific projects with Dr Angelo Amoroso please review the Molecular synthesis section of our research project themes.

Teaching

CH5202 - Reactivity And Properties Of The Elements And Their Compounds

CH2301 - Training in Research methods

CH4302 - Advanced Organometallic and Coordination Chemistry

CH3403 - Bio-imaging Applications of Coordination Chemistry

Details of modules can be found in course finder.

Biography

PhD, University of Cambridge (1992, B. F. G. Johnson and J. Lewis, synthesis of high nuclearity osmium carbonyl clusters). Postdoctoral Research Fellow, Bristol (1992-1995, J. A. McCleverty and M. D. Ward, synthesis and properties of Mo(NO) species). Postdoctoral Research Fellow, University of Utah (1995-1997, J. A. Gladysz, synthesis and properties of Re(NO) species linked by polyacetylene fragments). Postdoctoral Research Fellow, University of Nottingham (1997-1998, M. Schröder, modelling Ni/Fe hydrogenases). Appointed Lecturer in Inorganic Chemistry, Cardiff, 1998.

Contact Details

Research themes

Specialisms

  • Inorganic chemistry