![Angela Casbard MSc BSc](https://profiles-cardiff.imgix.net/attachments/649?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Angela Casbard
(she/her)
MSc BSc
Deputy Director of Cancer Division and Senior Research Fellow - Statistics
Overview
I am Deputy Director for the Cancer Division and Senior Research Fellow in statistics at the Centre for Trials Research. My research portfolio includes trials in a wide range of cancer sites, including skin cancer (SCC-AFTER), acute myeloid leukaemia (OPTIMISE), peritoneal metstases from colorectal, ovarian and stomach cancer (PICCOS), breast cancer (ZICE, FAKTION, FURVA), lung cancer & mesothelioma (QuicDNA, PIN, VIM, SKOPOS), bladder (TOUCAN, SUCCINCT) and gynaecolgical cancers (CEBOC, COPELIA). My interests include designing more efficient and adaptive platform and master protocol basket/umbrella designs that do not necessarily focus on one particular cancer site. A few of my recent trials have employed group-sequential and multi-arm-multi-stage methodology.
A lot of my work focusses on developing trial design ideas with clinicians, from the initial concept to the funding applications, and then overseeing the scientific and statistical aspects of funded trials, through to the publication stage.
Publication
2024
- Kohn, C. et al. 2024. Remotely delivered video interaction guidance for families of children with an intellectual disability referred to specialist mental health services: protocol for a feasibility randomized controlled trial. JMIR Research Protocols 13, article number: e54619. (10.2196/54619)
- Randell, E. et al. 2024. Watch Me Play! A pilot feasibility study of a remotely- delivered intervention to promote mental health resilience for children (aged 0-8) across UK early years and children's services.. Project Report. Foundations.
- Ajakaiye, A. et al. 2024. Pressurised intraperitoneal aerosolised chemotherapy in the management of cancer of the colon, ovary and stomach: phase II randomised controlled trial of efficacy in peritoneal metastases. Presented at: International Society of Gynecologic Cancer 2024 Annual Global Meeting, Dublin, Ireland, 16-18 October 2024, Vol. 34. BMJ Publishing Group pp. A350-A351., (10.1136/ijgc-2024-IGCS.611)
- Totsika, V. et al. 2024. Mapping the pathway and support offered to children with an intellectual disability referred to specialist mental health services in the UK.. BJPsych Bulletin (10.1192/bjb.2024.63)
- Murphy, A. D. et al. 2024. Once daily cediranib and weekly paclitaxel to prevent malignant bowel obstruction in at-risk patients with platinum-resistant ovarian cancer (CEBOC): a single-arm, phase II safety trial. International Journal of Gynecological Cancer 34, pp. 1034-1040. (10.1136/ijgc-2024-005455)
- Randell, E. et al. 2024. Watch Me Play!: protocol for a feasibility study of a remotely delivered intervention to promote mental health resilience for children (ages 0–8) across UK early years and children’s services. Pilot and Feasibility Studies 10(1), article number: 55. (10.1186/s40814-024-01491-7)
2023
- Jones, S. E. F. et al. 2023. Launching the PICCOS trial: PIPAC in cancers of the colon, ovary and stomach. Presented at: European Society of Gynaecological Society Congress, Istanbul, Turkey, 28 September - 01 October 2023. BMJ Publishing Group, (10.1136/ijgc-2023-ESGO.690)
- Beresford, M. et al. 2023. Fulvestrant plus vandetanib versus placebo for the treatment of patients with metastatic breast cancer resistant to aromatase inhibitor therapy (FURVA): a multicentre, Phase 2, randomised controlled trial. BJC Reports 1(1), article number: 13. (10.1038/s44276-023-00016-8)
- Kitson, T. et al. 2023. HIDDEN2: Study protocol for the hospital deep vein thrombosis detection study in patients with cancer receiving palliative care. BMJ Open 13(9), article number: e073049. (10.1136/bmjopen-2023-073049)
2022
- Fennell, D. A. et al. 2022. Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial. EClinicalMedicine 52, article number: 101595. (10.1016/j.eclinm.2022.101595)
- Howell, S. J. et al. 2022. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. The Lancet Oncology 23(7), pp. 851-864. (10.1016/s1470-2045(22)00284-4)
- Fennell, D. A. et al. 2022. Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine 48, article number: 101432. (10.1016/j.eclinm.2022.101432)
2020
- Jones, R. et al. 2020. A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer patients not suitable to receive cisplatin. BJU International 126(2), pp. 292-299. (10.1111/bju.15096)
- Jones, R. H. et al. 2020. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial. Lancet Oncology 21(3), pp. 345-347. (10.1016/S1470-2045(19)30817-4)
2018
- Lester, J. F. et al. 2018. A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma - the SKOPOS trial. OncoImmunology 7(12), article number: e1457597. (10.1080/2162402X.2018.1457597)
2017
- Gillespie, D. et al. 2017. The use of randomisation-based efficacy estimators in non-inferiority trials. Trials 18(1), article number: 117. (10.1186/s13063-017-1837-3)
2016
- Harrop, E., Kelly, J., Griffiths, G., Casbard, A. C. and Nelson, A. 2016. Why do patients decline surgical trials? Findings from a qualitative interview study embedded in the Cancer Research UK BOLERO trial (Bladder cancer: Open versus Lapararoscopic or RObotic cystectomy). Trials 17, article number: 35. (10.1186/s13063-016-1173-z)
- Jones, R. J. et al. 2016. TOUCAN: A randomised phase II trial of carboplatin and gemcitabine plus /- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin [Abstract]. American Journal of Clinical Oncology 34(S25), article number: 448.
2015
- Gillespie, D. et al. 2015. The use of randomisation-based efficacy estimators in non-inferiority trials [Poster Presentation]. Trials 16(Suppl), pp. P129. (10.1186/1745-6215-16-S2-P129)
- Noble, S. I. et al. 2015. A feasibility study to inform the design of a randomised controlled trial to identify the most clinically effective and cost-effective length of Anticoagulation with Low-molecular-weight heparin In the treatment of Cancer-Associated Thrombosis (ALICAT). Health Technology Assessment 19(83), pp. 1-94. (10.3310/hta19830)
- Geldart, T. et al. 2015. SUCCINCT: an open-label, single-arm, non-randomised, phase 2 trial of gemcitabine and cisplatin chemotherapy in combination with sunitinib as first-line treatment for patients with advanced urothelial carcinoma. European Urology 67(4), pp. 599-602. (10.1016/j.eururo.2014.11.003)
2014
- Noble, S. et al. 2014. ALICAT: Anticoagulation length in cancer associated thrombosis - a mixed-methods feasibility study. Thrombosis Research 133(Supp 2), pp. S220-S220. (10.1016/S0049-3848(14)50032-1)
- Barrett-Lee, P. et al. 2014. Oral ibandronic acid versus intravenous zoledronic acid in treatment of bone metastases from breast cancer: a randomised, open label, non-inferiority phase 3 trial. Lancet Oncology 15(1), pp. 114-122. (10.1016/S1470-2045(13)70539-4)
- Smith, J. D. et al. 2014. A feasibility study to inform the design of a randomized controlled trial to identify the most clinically and cost effective Anticoagulation Length with low molecular weight heparin In the treatment of Cancer Associated Thrombosis (ALICAT): study protocol for a mixed-methods study. Trials 15(1), article number: 122. (10.1186/1745-6215-15-122)
- Noble, S. I. R. et al. 2014. Anticoagulation length in cancer associated thrombosis: a mixed-methods feasibility study. Presented at: International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, Italy, 9-11 May 2014.
2013
- Harrop, E. et al. 2013. ‘Once I knew there was a choice, I wanted to exercise that choice': using qualitative methods to understand why patients decline surgical trials.. Trials 14(S1), article number: P9 (2013). (10.1186/1745-6215-14-s1-p9)
- Powell, J. R. et al. 2013. Prognostic significance of hypoxia inducible factor-1α and vascular endothelial growth factor expression in patients with diffuse large B-cell lymphoma treated with rituximab.. Leukemia & Lymphoma 54(5), pp. 959-966. (10.3109/10428194.2012.733875)
2009
- Nixon, L. S., Wills, L., Staffurth, J. N., Crosby, T. D. L., Casbard, A. C. and Griffiths, G. 2009. Implementation of a QA RT substudy for SCOPE 1; Preliminary results for test cases [Abstract]. Clinical Oncology 21(3), pp. 255-255. (10.1016/j.clon.2009.01.001,)
- Llewelyn, C. A. et al. 2009. The EASTR study: a new approach to determine the reasons for transfusion in epidemiological studies. Transfusion Medicine 19(2), pp. 89-98. (10.1111/j.1365-3148.2009.00911.x)
- Wells, A. W. et al. 2009. The EASTR Study: indications for transfusion and estimates of transfusion recipient numbers in hospitals supplied by the National Blood Service. Transfusion Medicine 19(6), pp. 315-328. (10.1111/j.1365-3148.2009.00933.x)
- Cooke, D. et al. 2009. Randomized controlled trial to assess the impact of continuous glucose monitoring on HbA1cin insulin-treated diabetes (MITRE Study). Diabetic Medicine 26(5), pp. 540-547. (10.1111/j.1464-5491.2009.02723.x)
- Morgan, M. A. et al. 2009. Stage-for-stage comparison of definitive chemoradiotherapy, surgery alone and neoadjuvant chemotherapy for oesophageal carcinoma. British Journal of Surgery 96(11), pp. 1300-1307. (10.1002/bjs.6705)
2007
- Williamson, L. M. et al. 2007. The impact of universal leukodepletion of the blood supply on hemovigilance reports of posttransfusion purpura and transfusion-associated graft-versus-host disease. Transfusion 47(8), pp. 1455-1467. (10.1111/j.1537-2995.2007.01281.x)
- Ghevaert, C. et al. 2007. HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia. Transfusion 47(7), pp. 1296-1305. (10.1111/j.1537-2995.2007.01273.x)
2006
- Williamson, M., Stainsby, D., Jones, H., Love, E., Chapman, C., Casbard, A. and Cohen, H. 2006. Haemovigilance reports of post-transfusion purpura and transfusion-associated graft-versus-host disease before and after implementation of universal leucocyte depletion in the UK. Vox Sanguinis 91(Supp 3), pp. 15-15. (10.1111/j.0042-9007.2006.vox_v91_is3_mondaysessions.x)
- Stanworth, S. J., Dyer, C., Casbard, A. C. and Murphy, M. F. 2006. Feasibility and usefulness of self-assessment of bleeding in patients with haematological malignancies, and the association between platelet count and bleeding. Vox Sanguinis 91(1), pp. 63-69. (10.1111/j.1423-0410.2006.00785.x)
- Davies, A., Staves, J., Kay, J., Casbard, A. C. and Murphy, M. F. 2006. End-to-end electronic control of the hospital transfusion process to increase the safety of blood transfusion: strengths and weaknesses. Transfusion 46(3), pp. 352-364. (10.1111/j.1537-2995.2006.00729.x)
- Grover, M. et al. 2006. Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. Vox Sanguinis 90(2), pp. 105-112. (10.1111/j.1423-0410.2006.00730.x)
2005
- Buck, J., Casbard, A. C., Llewelyn, C., Johnson, T., Davies, S. and Williamson, L. 2005. Preoperative transfusion in sickle cell disease: a survey of practice in England. European Journal of Haematology 75(1), pp. 14-21. (10.1111/j.1600-0609.2005.00412.x)
- Segal, H. C., Briggs, C., Kunka, S., Casbard, A. C., Harrison, P., Machin, S. J. and Murphy, M. F. 2005. Accuracy of platelet counting haematology analysers in severe thrombocytopenia and potential impact on platelet transfusion. British Journal of Haematology 128(4), pp. 520-525. (10.1111/j.1365-2141.2004.05352.x)
2004
- Allain, J., Anokwa, M., Casbard, A. C., Owusu-Ofori, S. and Dennis-Antwi, J. 2004. Sociology and behaviour of West African blood donors: the impact of religion on human immunodeficiency virus infection. Vox Sanguinis 87(4), pp. 233-240. (10.1111/j.1423-0410.2004.00578.x)
- McPherson, K. et al. 2004. Severe complications of hysterectomy: the VALUE study. BJOG - an International Journal of Obstetrics and Gynaecology 111(7), pp. 688-694. (10.1111/j.1471-0528.2004.00174.x)
- Boralessa, H., Cockburn, H., Casbard, A. C. and Contreras, M. 2004. Review of transfusion practice in orthopaedic surgery. Current Orthopaedics 18(2), pp. 126-134. (10.1016/j.cuor.2003.11.001)
- Strang, J. I. G., Nunn, A. J., Johnson, D. A., Casbard, A. C., Gibson, D. G. and Girling, D. J. 2004. Management of tuberculous constrictive pericarditis and tuberculous pericardial effusion in Transkei: results at 10 years follow-up. QJM: An International Journal of Medicine 97(8), pp. 525-535. (10.1093/qjmed/hch086)
2003
- Selden, C., Casbard, A., Themis, M. and Hodgson, H. J. 2003. Characterization of long-term survival of syngeneic hepatocytes in rat peritoneum. Cell Transplantation 12(6), pp. 569-578.
2002
- Maresh, M. J. A. et al. 2002. The VALUE national hysterectomy study: description of the patients and their surgery. BJOG: An International Journal of Obstetrics & Gynaecology 109(3), pp. 302-312. (10.1016/S1470-0328(02)01282-X)
Articles
- Kohn, C. et al. 2024. Remotely delivered video interaction guidance for families of children with an intellectual disability referred to specialist mental health services: protocol for a feasibility randomized controlled trial. JMIR Research Protocols 13, article number: e54619. (10.2196/54619)
- Totsika, V. et al. 2024. Mapping the pathway and support offered to children with an intellectual disability referred to specialist mental health services in the UK.. BJPsych Bulletin (10.1192/bjb.2024.63)
- Murphy, A. D. et al. 2024. Once daily cediranib and weekly paclitaxel to prevent malignant bowel obstruction in at-risk patients with platinum-resistant ovarian cancer (CEBOC): a single-arm, phase II safety trial. International Journal of Gynecological Cancer 34, pp. 1034-1040. (10.1136/ijgc-2024-005455)
- Randell, E. et al. 2024. Watch Me Play!: protocol for a feasibility study of a remotely delivered intervention to promote mental health resilience for children (ages 0–8) across UK early years and children’s services. Pilot and Feasibility Studies 10(1), article number: 55. (10.1186/s40814-024-01491-7)
- Beresford, M. et al. 2023. Fulvestrant plus vandetanib versus placebo for the treatment of patients with metastatic breast cancer resistant to aromatase inhibitor therapy (FURVA): a multicentre, Phase 2, randomised controlled trial. BJC Reports 1(1), article number: 13. (10.1038/s44276-023-00016-8)
- Kitson, T. et al. 2023. HIDDEN2: Study protocol for the hospital deep vein thrombosis detection study in patients with cancer receiving palliative care. BMJ Open 13(9), article number: e073049. (10.1136/bmjopen-2023-073049)
- Fennell, D. A. et al. 2022. Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial. EClinicalMedicine 52, article number: 101595. (10.1016/j.eclinm.2022.101595)
- Howell, S. J. et al. 2022. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. The Lancet Oncology 23(7), pp. 851-864. (10.1016/s1470-2045(22)00284-4)
- Fennell, D. A. et al. 2022. Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine 48, article number: 101432. (10.1016/j.eclinm.2022.101432)
- Jones, R. et al. 2020. A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer patients not suitable to receive cisplatin. BJU International 126(2), pp. 292-299. (10.1111/bju.15096)
- Jones, R. H. et al. 2020. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial. Lancet Oncology 21(3), pp. 345-347. (10.1016/S1470-2045(19)30817-4)
- Lester, J. F. et al. 2018. A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma - the SKOPOS trial. OncoImmunology 7(12), article number: e1457597. (10.1080/2162402X.2018.1457597)
- Gillespie, D. et al. 2017. The use of randomisation-based efficacy estimators in non-inferiority trials. Trials 18(1), article number: 117. (10.1186/s13063-017-1837-3)
- Harrop, E., Kelly, J., Griffiths, G., Casbard, A. C. and Nelson, A. 2016. Why do patients decline surgical trials? Findings from a qualitative interview study embedded in the Cancer Research UK BOLERO trial (Bladder cancer: Open versus Lapararoscopic or RObotic cystectomy). Trials 17, article number: 35. (10.1186/s13063-016-1173-z)
- Jones, R. J. et al. 2016. TOUCAN: A randomised phase II trial of carboplatin and gemcitabine plus /- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin [Abstract]. American Journal of Clinical Oncology 34(S25), article number: 448.
- Gillespie, D. et al. 2015. The use of randomisation-based efficacy estimators in non-inferiority trials [Poster Presentation]. Trials 16(Suppl), pp. P129. (10.1186/1745-6215-16-S2-P129)
- Noble, S. I. et al. 2015. A feasibility study to inform the design of a randomised controlled trial to identify the most clinically effective and cost-effective length of Anticoagulation with Low-molecular-weight heparin In the treatment of Cancer-Associated Thrombosis (ALICAT). Health Technology Assessment 19(83), pp. 1-94. (10.3310/hta19830)
- Geldart, T. et al. 2015. SUCCINCT: an open-label, single-arm, non-randomised, phase 2 trial of gemcitabine and cisplatin chemotherapy in combination with sunitinib as first-line treatment for patients with advanced urothelial carcinoma. European Urology 67(4), pp. 599-602. (10.1016/j.eururo.2014.11.003)
- Noble, S. et al. 2014. ALICAT: Anticoagulation length in cancer associated thrombosis - a mixed-methods feasibility study. Thrombosis Research 133(Supp 2), pp. S220-S220. (10.1016/S0049-3848(14)50032-1)
- Barrett-Lee, P. et al. 2014. Oral ibandronic acid versus intravenous zoledronic acid in treatment of bone metastases from breast cancer: a randomised, open label, non-inferiority phase 3 trial. Lancet Oncology 15(1), pp. 114-122. (10.1016/S1470-2045(13)70539-4)
- Smith, J. D. et al. 2014. A feasibility study to inform the design of a randomized controlled trial to identify the most clinically and cost effective Anticoagulation Length with low molecular weight heparin In the treatment of Cancer Associated Thrombosis (ALICAT): study protocol for a mixed-methods study. Trials 15(1), article number: 122. (10.1186/1745-6215-15-122)
- Harrop, E. et al. 2013. ‘Once I knew there was a choice, I wanted to exercise that choice': using qualitative methods to understand why patients decline surgical trials.. Trials 14(S1), article number: P9 (2013). (10.1186/1745-6215-14-s1-p9)
- Powell, J. R. et al. 2013. Prognostic significance of hypoxia inducible factor-1α and vascular endothelial growth factor expression in patients with diffuse large B-cell lymphoma treated with rituximab.. Leukemia & Lymphoma 54(5), pp. 959-966. (10.3109/10428194.2012.733875)
- Nixon, L. S., Wills, L., Staffurth, J. N., Crosby, T. D. L., Casbard, A. C. and Griffiths, G. 2009. Implementation of a QA RT substudy for SCOPE 1; Preliminary results for test cases [Abstract]. Clinical Oncology 21(3), pp. 255-255. (10.1016/j.clon.2009.01.001,)
- Llewelyn, C. A. et al. 2009. The EASTR study: a new approach to determine the reasons for transfusion in epidemiological studies. Transfusion Medicine 19(2), pp. 89-98. (10.1111/j.1365-3148.2009.00911.x)
- Wells, A. W. et al. 2009. The EASTR Study: indications for transfusion and estimates of transfusion recipient numbers in hospitals supplied by the National Blood Service. Transfusion Medicine 19(6), pp. 315-328. (10.1111/j.1365-3148.2009.00933.x)
- Cooke, D. et al. 2009. Randomized controlled trial to assess the impact of continuous glucose monitoring on HbA1cin insulin-treated diabetes (MITRE Study). Diabetic Medicine 26(5), pp. 540-547. (10.1111/j.1464-5491.2009.02723.x)
- Morgan, M. A. et al. 2009. Stage-for-stage comparison of definitive chemoradiotherapy, surgery alone and neoadjuvant chemotherapy for oesophageal carcinoma. British Journal of Surgery 96(11), pp. 1300-1307. (10.1002/bjs.6705)
- Williamson, L. M. et al. 2007. The impact of universal leukodepletion of the blood supply on hemovigilance reports of posttransfusion purpura and transfusion-associated graft-versus-host disease. Transfusion 47(8), pp. 1455-1467. (10.1111/j.1537-2995.2007.01281.x)
- Ghevaert, C. et al. 2007. HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia. Transfusion 47(7), pp. 1296-1305. (10.1111/j.1537-2995.2007.01273.x)
- Williamson, M., Stainsby, D., Jones, H., Love, E., Chapman, C., Casbard, A. and Cohen, H. 2006. Haemovigilance reports of post-transfusion purpura and transfusion-associated graft-versus-host disease before and after implementation of universal leucocyte depletion in the UK. Vox Sanguinis 91(Supp 3), pp. 15-15. (10.1111/j.0042-9007.2006.vox_v91_is3_mondaysessions.x)
- Stanworth, S. J., Dyer, C., Casbard, A. C. and Murphy, M. F. 2006. Feasibility and usefulness of self-assessment of bleeding in patients with haematological malignancies, and the association between platelet count and bleeding. Vox Sanguinis 91(1), pp. 63-69. (10.1111/j.1423-0410.2006.00785.x)
- Davies, A., Staves, J., Kay, J., Casbard, A. C. and Murphy, M. F. 2006. End-to-end electronic control of the hospital transfusion process to increase the safety of blood transfusion: strengths and weaknesses. Transfusion 46(3), pp. 352-364. (10.1111/j.1537-2995.2006.00729.x)
- Grover, M. et al. 2006. Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. Vox Sanguinis 90(2), pp. 105-112. (10.1111/j.1423-0410.2006.00730.x)
- Buck, J., Casbard, A. C., Llewelyn, C., Johnson, T., Davies, S. and Williamson, L. 2005. Preoperative transfusion in sickle cell disease: a survey of practice in England. European Journal of Haematology 75(1), pp. 14-21. (10.1111/j.1600-0609.2005.00412.x)
- Segal, H. C., Briggs, C., Kunka, S., Casbard, A. C., Harrison, P., Machin, S. J. and Murphy, M. F. 2005. Accuracy of platelet counting haematology analysers in severe thrombocytopenia and potential impact on platelet transfusion. British Journal of Haematology 128(4), pp. 520-525. (10.1111/j.1365-2141.2004.05352.x)
- Allain, J., Anokwa, M., Casbard, A. C., Owusu-Ofori, S. and Dennis-Antwi, J. 2004. Sociology and behaviour of West African blood donors: the impact of religion on human immunodeficiency virus infection. Vox Sanguinis 87(4), pp. 233-240. (10.1111/j.1423-0410.2004.00578.x)
- McPherson, K. et al. 2004. Severe complications of hysterectomy: the VALUE study. BJOG - an International Journal of Obstetrics and Gynaecology 111(7), pp. 688-694. (10.1111/j.1471-0528.2004.00174.x)
- Boralessa, H., Cockburn, H., Casbard, A. C. and Contreras, M. 2004. Review of transfusion practice in orthopaedic surgery. Current Orthopaedics 18(2), pp. 126-134. (10.1016/j.cuor.2003.11.001)
- Strang, J. I. G., Nunn, A. J., Johnson, D. A., Casbard, A. C., Gibson, D. G. and Girling, D. J. 2004. Management of tuberculous constrictive pericarditis and tuberculous pericardial effusion in Transkei: results at 10 years follow-up. QJM: An International Journal of Medicine 97(8), pp. 525-535. (10.1093/qjmed/hch086)
- Selden, C., Casbard, A., Themis, M. and Hodgson, H. J. 2003. Characterization of long-term survival of syngeneic hepatocytes in rat peritoneum. Cell Transplantation 12(6), pp. 569-578.
- Maresh, M. J. A. et al. 2002. The VALUE national hysterectomy study: description of the patients and their surgery. BJOG: An International Journal of Obstetrics & Gynaecology 109(3), pp. 302-312. (10.1016/S1470-0328(02)01282-X)
Conferences
- Ajakaiye, A. et al. 2024. Pressurised intraperitoneal aerosolised chemotherapy in the management of cancer of the colon, ovary and stomach: phase II randomised controlled trial of efficacy in peritoneal metastases. Presented at: International Society of Gynecologic Cancer 2024 Annual Global Meeting, Dublin, Ireland, 16-18 October 2024, Vol. 34. BMJ Publishing Group pp. A350-A351., (10.1136/ijgc-2024-IGCS.611)
- Jones, S. E. F. et al. 2023. Launching the PICCOS trial: PIPAC in cancers of the colon, ovary and stomach. Presented at: European Society of Gynaecological Society Congress, Istanbul, Turkey, 28 September - 01 October 2023. BMJ Publishing Group, (10.1136/ijgc-2023-ESGO.690)
- Noble, S. I. R. et al. 2014. Anticoagulation length in cancer associated thrombosis: a mixed-methods feasibility study. Presented at: International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, Italy, 9-11 May 2014.
Monographs
- Randell, E. et al. 2024. Watch Me Play! A pilot feasibility study of a remotely- delivered intervention to promote mental health resilience for children (aged 0-8) across UK early years and children's services.. Project Report. Foundations.
Research
My interests lie in design and analysis of a variety of oncology trials. I am particulalry interested in efficient trial designs and platform trials.
I have recently been involved in acute myeloid leukaemia trials, with one recently funded trial, called OPTIMISE, looking at the best treatment for newly diagnosed patients with the FLT3 mutation. OPTIMISE uses a multi-arm multi-stage design, comparing
I'm currently working on two active gynaecological trials: the COPELIA trial is evaluating whether cediranib and olaparib can improve time to cancer progression in endometrial cancer; the CEBOC trial is investigating the safety of treating ovarian cancer patients who at high risk of bowel obstruction with cediranib. I also oversee the statistical aspects of the CORINTH trial, which is an early phase trial assessing the safety of pembrolizumab in HPV related anal cancer, and the ADVANCE study which is evaluating the use of a machine that can be used in clinic to check the blood counts of chemotherapy patients and look for signs of neutropenic sepsis.
My interests also include breast cancer, the ZICE trial was a large phase 3 trial which evaluated whether oral ibandronate tablets were not inferior to IV zoledronate in the treatment of bone metastases in breast cancer patients. We were not able to conclude non-inferiority, and IV zoledronate remained the preferred treatment, but oral ibandronate could still be considered for patients wanting to avoid IV infusions. The FAKTION trial is a phase 2 trial in ER positive breast cancer patients evaluatign whether a new treatment capivasertib could improve time to disease progression when added to fulvestrant hormone therapy, the main results published in 2020 showed that the time to disease progression was longer in those patients receiving capivasertib. We are currently looking at the longer term follow-up data of FAKTION patients, to see whether the capivasertib also improves overall survival, and whether patients with certain gene mutations in the tumour, related to the AKT signalling pathway, are more likely to benefit from treatment. A similar trial FURVA, looking at whether the addition of vandetanib to fulvestrant hormone therapy can improve time to disease progression was also conducted in patients with ER positive breast cancer and we plan to publish the results this year. Both FAKTION and FURVA trials were conducted in collaboration with AstraZeneca, and were additionally funded and endorsed by CRUK.
Biography
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Career Overview: Centre for Trials Research, Cardiff University Deputy Director - Cancer Division Nov 2020 – Current Centre for Trials Research, Cardiff University Senior Research Fellow (Statistics) Feb 2007 – Current
MRC Clinical Trials Unit, London Statistician Jan 2002 – Jan 2007
London School of Hygiene and Tropical Medicine Statistician Oct 2000 – Dec 2001 Imperial College, Hammersmith Hospital Research Assistant Dec 1997 – Sep 1999 Qualitfications: MSc Medical Statistics London School of Hygiene and Tropical Medicine, 1999-2000 BSc Biochemistry (Medical) Royal Holloway, University of London 1994-1997 |
Committees and reviewing
- Current independent member (statistician) on the CRUK Glasgow CTU Glasgow Umbrella Trials Steering Committee 2
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Current independent member of C- ProMeta 1 Trial Steering committee
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Current member of Blood Cancer UK Clinical Trials Review Committee
Supervisions
I have supervised intercalated BSc and MSc projects, where students analysed quality of life and genetic data from our trials and linked it to the trial's clinical databases.
Contact Details
Research themes
Specialisms
- clinical trials
- Oncology and carcinogenesis
- Statistics