![Sharon Dewitt](https://profiles-cardiff.imgix.net/attachments/670?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
Research theme
Research group
Matrix Biology and Tissue Repair
Research interests
The focus of my research is to identify the early cellular events that occur in disease processes such as arthritis. These early events can then be exploited as indicators of disease to enable early diagnosis and treatment; or as a means of manipulation and modification of the disease process.
Associated research within the School of Dentistry is focused on how extracellular matrix guides cellular responses in physiological processes but also how alterations in its constituents contribute to major diseases including arthritis.
Areas of expertise:
- Calcium imaging
- Confocal microscopy
- Single cell Imaging
- Neutrophil biology
- Micromanipulation/Microinjection
Ongoing Projects:
- Validation of a stem cell derived cartilage model for osteoarthritis research and drug screening
- Role of sensor protein in development of osteoarthritis
- Investigating a candidate biomarker of osteoarthritis: Role in pathogenesis and efficacy to diagnose disease
- Evaluating of inactivation of signalling networks by EBC-46 in head and neck cancer
- Determining the role of ADAM15 in Head and Neck and other cancers
- Novel cancer drug regulates disintegrin and metalloproteinase (ADAM) activity in Head and Neck cancer
- Identifying a utility for dentally derived extracellular vesicles to restore impaired bone healing associated with age-related systemic conditions
- Control of the surface topology of human neutrophils
Publication
2024
- Antwi, F. D. et al. 2024. Tigilanol tiglate-induced changes in secretome profiles alter c-Met phosphorylation and cell surface protein expression in H357 head and neck cancer cells. Cells 13(11), article number: 982. (10.3390/cells13110982)
- Dewitt, S., Green, J., Laffafian, I., Lewis, K. J. and Hallett, M. B. 2024. Intraphagosomal free Ca2+changes during phagocytosis. International Journal of Molecular Sciences 25(8), article number: 4254. (10.3390/ijms25084254)
- Bauer, L., Edwards, J., Heil, A., Dewitt, S., Biebermann, H., Aeschlimann, D. and Knauper, V. 2024. Mesenchymal transglutaminase 2 activates epithelial ADAM17: link to G-protein coupled receptor 56 (ADGRG1) signalling. International Journal of Molecular Sciences 25(4), article number: 2329. (10.3390/ijms25042329)
2022
- Brown, S. V., Dewitt, S., Clayton, A. and Waddington, R. J. 2022. Identifying the efficacy of extracellular vesicles in osteogenic differentiation: an EV-Lution in regenerative medicine. Frontiers in Dental Medicine 3, article number: 849724. (10.3389/fdmed.2022.849724)
2020
- Al-Jumaa, M., Hallett, M. B. and Dewitt, S. 2020. Cell surface topography controls phagocytosis and cell spreading: the membrane reservoir in neutrophils. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 12, article number: 118832. (10.1016/j.bbamcr.2020.118832)
- Dewitt, S. and Hallett, M. B. 2020. Calpain activation by Ca2+ and its role in phagocytosis. In: Hallett, M. B. ed. Molecular and Cellular Biology of Phagocytosis., Vol. 1246. Advances in Experimental Medicine and Biology Switzerland: Springer, pp. 129-151., (10.1007/978-3-030-40406-2_8)
- Roberts, R. E., Dewitt, S. and Hallett, M. B. 2020. Membrane tension and the role of ezrin during phagocytosis. In: Hallett, M. B. ed. Molecular and Cellular Biology of Phagocytosis., Vol. 1246. Advances in Experimental Medicine and Biology Switzerland: Springer, pp. 83-102., (10.1007/978-3-030-40406-2_6)
2019
- Hallett, M. B., Roberts, R. E. and Dewitt, S. 2019. Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils. In: Neutrophil., Vol. 2087. Methods in Molecular Biology New York: Humana Press, pp. 191-205., (10.1007/978-1-0716-0154-9_14)
2017
- Jumaa, M. A. A., Dewitt, S. and Hallett, M. B. 2017. Topographical interrogation of the living cell surface reveals its role in rapid cell shape changes during phagocytosis and spreading. Scientific Reports 7, pp. -., article number: 9790. (10.1038/s41598-017-09761-6)
2015
- Adamczyk, M., Griffiths, R., Dewitt, S., Knauper, V. and Aeschlimann, D. 2015. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. Journal of Cell Science 128(24), pp. 4615-4628. (10.1242/jcs.175968)
- Wanger, T. M., Dewitt, S., Collins, A., Maitland, N. J., Poghosyan, Z. and Knauper, V. 2015. Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cellular Signalling 27(7), pp. 1325-1335. (10.1016/j.cellsig.2015.03.017)
2014
- Lewis, K. J., Masterman, B., Laffafian, I., Dewitt, S., Campbell, J. S. and Hallett, M. B. 2014. Minimal impact electro-injection of cells undergoing dynamic shape change reveals calpain activation. BBA - Molecular Cell Research 1843(6), pp. 1182-1187. (10.1016/j.bbamcr.2014.02.020)
- Hallett, M., Al-Jumaa, M. and Dewitt, S. 2014. Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils. In: Quinn, M. T. and DeLeo, F. R. eds. Neutrophil Methods and Protocols. Methods in Molecular Biology Vol. 1124. Humana Press, pp. 107-120., (10.1007/978-1-62703-845-4_8)
2013
- Dewitt, S., Francis, R. J. and Hallett, M. B. 2013. Ca2+ and calpain control membrane expansion during rapid cell spreading of neutrophils. Journal of Cell Science 126(20), pp. 4627-4635. (10.1242/jcs.124917)
2011
- McDonald, J. U. et al. 2011. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. The FASEB Journal 25(6), pp. 1972-1982. (10.1096/fj.10-178517)
- Dewitt, S. and Hallett, M. B. 2011. Optical complexities of living cytoplasm - implications for live cell imaging and photo-micromanipulation techniques. Journal of Microscopy 241(3), pp. 221-224. (10.1111/j.1365-2818.2010.03451.x)
- Lewis, K., Dewitt, S. and Hallett, M. B. 2011. The role of calpain translocation in neutrophil spreading [Abstract]. European Journal of Clinical Investigation 41(s1), pp. 47. (10.1111/j.1365-2362.2011.02508.x)
- Ishak, R., Dewitt, S. and Hallett, M. B. 2011. Calpain-1: investigating its role in murine neutrophils [Abstract]. European Journal of Clinical Investigation 41(s1), pp. 24. (10.1111/j.1365-2362.2011.02508.x)
- Hallett, M. B. and Dewitt, S. 2011. A trick of the light: the optical properties of living cytoplasm which can mislead. Integrative Biology 3(3), pp. 180-184. (10.1039/c0ib00039f)
- Elumalai, G. L., Dewitt, S. and Hallett, M. B. 2011. Ezrin and talin relocates from the plasma membrane to cytosol during neutrophil extravasation [Abstract]. European Journal of Clinical Investigation 41(s1), pp. 47. (10.1111/j.1365-2362.2011.02508.x)
2010
- Brasen, J. C., Dewitt, S. and Hallett, M. B. 2010. A reporter of UV intensity delivered to the cytosol during photolytic uncaging. Biophysical Journal 98(7), pp. L25-L27. (10.1016/j.bpj.2009.12.4271)
2009
- Dewitt, S., Darley, R. L. and Hallett, M. B. 2009. Translocation or just location? Pseudopodia affect fluorescent signals. Journal of Cell Biology 184(2), pp. 197-203. (10.1083/jcb.200806047)
2008
- Hallett, M. . B., Von Ruhland, C. J. and Dewitt, S. 2008. Chemotaxis and the cell surface-area problem [Letter]. Nature Reviews Molecular Cell Biology 9(8), pp. 662. (10.1038/nrm2419-c1)
2007
- Dewitt, S. and Hallett, M. B. 2007. Leukocyte membrane 'expansion': a central mechanism for leukocyte extravasation. Journal of leukocyte biology 81(5), pp. 1160-1164. (10.1189/jlb.1106710)
- Hillson, E. J., Dewitt, S. and Hallett, M. B. 2007. Optical methods for the measurement and manipulation of cytosolic free calcium in neutrophils. In: Quinn, M. T., DeLeo, F. R. and Bokoch, G. M. eds. Neutrophil Methods and Protocols. Methods in Molecular Biology Vol. 412. Totowa, NJ: Humana Press, pp. 125-137., (10.1007/978-1-59745-467-4_10)
2006
- Hallett, M. B., Dewitt, S. and Tian, W. 2006. Localised PtdIns(3,4,5)P3 or PtdIns(3,4)P2 at the phagocytic cup is required for both phagosome closure and Ca2+ signalling in HL60 neutrophils. Journal of Cell Science 119(3), pp. 443-51. (10.1242/jcs.02756)
2004
- Ayub, K., Laffaffian, I., Dewitt, S. and Hallett, M. B. 2004. Ca2+ influx shutdown in neutrophils induced by Fas (CD95) cross-linking. Immunology 112(3), pp. 454-460. (10.1111/j.1365-2567.2004.01899.x)
- Clayton, A., Turkes, A., Dewitt, S., Steadman, R., Mason, M. D. and Hallett, M. B. 2004. Adhesion and signaling by B cell-derived exosomes: the role of integrins. The FASEB Journal 18, pp. 977-979. (10.1096/fj.03-1094fje)
2003
- Tian, W., Laffafian, I., Dewitt, S. and Hallett, M. B. 2003. Exclusion of exogenous phosphatidylinositol-3,4,5-trisphosphate from neutrophil-polarizing pseudopodia: stabilization of the uropod and cell polarity. EMBO Reports 4(10), pp. 982-988. (10.1038/sj.embor.embor947)
- Hallett, M. B., Laffafian, I. and Dewitt, S. 2003. Phagosomal oxidative activity during beta2 integrin (CR3)-mediated phagocytosis by neutrophils is triggered by a non-restricted Ca2+ signal: Ca2+ controls time not space. Journal of Cell Science 116(14), pp. 2857-65. (10.1242/jcs.00499)
- Morris, M. R., Dewitt, S., Laffafian, I. and Hallett, M. B. 2003. Phagocytosis by inflammatory phagocytes; experimental strategies for stimulation and quantification. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols. Methods in Molecular Biology Vol. 225. Totowa, NJ: Humana Press, pp. 35-46., (10.1385/1-59259-374-7:35)
- Hallett, M. B., Cole, C. and Dewitt, S. 2003. Detection and visualization of oxidase activity in phagocytes. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols., Vol. 225. Methods in Molecular Biology Totowa, NJ: Humana Press, pp. 61-67., (10.1385/1-59259-374-7:61)
- Dewitt, S., Laffafian, I., Morris, M. R. and Hallett, M. B. 2003. Cytosolic Ca2+ measurement and imaging in inflammatory cells. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols. Methods in Molecular Biology Vol. 255. Totowa, NJ: Humana Press, pp. 47-63., (10.1385/1-59259-374-7:47)
2002
- Hallett, M. B. and Dewitt, S. 2002. Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophils. The Journal of Cell Biology 159(1), pp. 181-9. (10.1083/jcb.200206089)
Adrannau llyfrau
- Dewitt, S. and Hallett, M. B. 2020. Calpain activation by Ca2+ and its role in phagocytosis. In: Hallett, M. B. ed. Molecular and Cellular Biology of Phagocytosis., Vol. 1246. Advances in Experimental Medicine and Biology Switzerland: Springer, pp. 129-151., (10.1007/978-3-030-40406-2_8)
- Roberts, R. E., Dewitt, S. and Hallett, M. B. 2020. Membrane tension and the role of ezrin during phagocytosis. In: Hallett, M. B. ed. Molecular and Cellular Biology of Phagocytosis., Vol. 1246. Advances in Experimental Medicine and Biology Switzerland: Springer, pp. 83-102., (10.1007/978-3-030-40406-2_6)
- Hallett, M. B., Roberts, R. E. and Dewitt, S. 2019. Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils. In: Neutrophil., Vol. 2087. Methods in Molecular Biology New York: Humana Press, pp. 191-205., (10.1007/978-1-0716-0154-9_14)
- Hallett, M., Al-Jumaa, M. and Dewitt, S. 2014. Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils. In: Quinn, M. T. and DeLeo, F. R. eds. Neutrophil Methods and Protocols. Methods in Molecular Biology Vol. 1124. Humana Press, pp. 107-120., (10.1007/978-1-62703-845-4_8)
- Hillson, E. J., Dewitt, S. and Hallett, M. B. 2007. Optical methods for the measurement and manipulation of cytosolic free calcium in neutrophils. In: Quinn, M. T., DeLeo, F. R. and Bokoch, G. M. eds. Neutrophil Methods and Protocols. Methods in Molecular Biology Vol. 412. Totowa, NJ: Humana Press, pp. 125-137., (10.1007/978-1-59745-467-4_10)
- Morris, M. R., Dewitt, S., Laffafian, I. and Hallett, M. B. 2003. Phagocytosis by inflammatory phagocytes; experimental strategies for stimulation and quantification. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols. Methods in Molecular Biology Vol. 225. Totowa, NJ: Humana Press, pp. 35-46., (10.1385/1-59259-374-7:35)
- Hallett, M. B., Cole, C. and Dewitt, S. 2003. Detection and visualization of oxidase activity in phagocytes. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols., Vol. 225. Methods in Molecular Biology Totowa, NJ: Humana Press, pp. 61-67., (10.1385/1-59259-374-7:61)
- Dewitt, S., Laffafian, I., Morris, M. R. and Hallett, M. B. 2003. Cytosolic Ca2+ measurement and imaging in inflammatory cells. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols. Methods in Molecular Biology Vol. 255. Totowa, NJ: Humana Press, pp. 47-63., (10.1385/1-59259-374-7:47)
Erthyglau
- Antwi, F. D. et al. 2024. Tigilanol tiglate-induced changes in secretome profiles alter c-Met phosphorylation and cell surface protein expression in H357 head and neck cancer cells. Cells 13(11), article number: 982. (10.3390/cells13110982)
- Dewitt, S., Green, J., Laffafian, I., Lewis, K. J. and Hallett, M. B. 2024. Intraphagosomal free Ca2+changes during phagocytosis. International Journal of Molecular Sciences 25(8), article number: 4254. (10.3390/ijms25084254)
- Bauer, L., Edwards, J., Heil, A., Dewitt, S., Biebermann, H., Aeschlimann, D. and Knauper, V. 2024. Mesenchymal transglutaminase 2 activates epithelial ADAM17: link to G-protein coupled receptor 56 (ADGRG1) signalling. International Journal of Molecular Sciences 25(4), article number: 2329. (10.3390/ijms25042329)
- Brown, S. V., Dewitt, S., Clayton, A. and Waddington, R. J. 2022. Identifying the efficacy of extracellular vesicles in osteogenic differentiation: an EV-Lution in regenerative medicine. Frontiers in Dental Medicine 3, article number: 849724. (10.3389/fdmed.2022.849724)
- Al-Jumaa, M., Hallett, M. B. and Dewitt, S. 2020. Cell surface topography controls phagocytosis and cell spreading: the membrane reservoir in neutrophils. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 12, article number: 118832. (10.1016/j.bbamcr.2020.118832)
- Jumaa, M. A. A., Dewitt, S. and Hallett, M. B. 2017. Topographical interrogation of the living cell surface reveals its role in rapid cell shape changes during phagocytosis and spreading. Scientific Reports 7, pp. -., article number: 9790. (10.1038/s41598-017-09761-6)
- Adamczyk, M., Griffiths, R., Dewitt, S., Knauper, V. and Aeschlimann, D. 2015. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. Journal of Cell Science 128(24), pp. 4615-4628. (10.1242/jcs.175968)
- Wanger, T. M., Dewitt, S., Collins, A., Maitland, N. J., Poghosyan, Z. and Knauper, V. 2015. Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cellular Signalling 27(7), pp. 1325-1335. (10.1016/j.cellsig.2015.03.017)
- Lewis, K. J., Masterman, B., Laffafian, I., Dewitt, S., Campbell, J. S. and Hallett, M. B. 2014. Minimal impact electro-injection of cells undergoing dynamic shape change reveals calpain activation. BBA - Molecular Cell Research 1843(6), pp. 1182-1187. (10.1016/j.bbamcr.2014.02.020)
- Dewitt, S., Francis, R. J. and Hallett, M. B. 2013. Ca2+ and calpain control membrane expansion during rapid cell spreading of neutrophils. Journal of Cell Science 126(20), pp. 4627-4635. (10.1242/jcs.124917)
- McDonald, J. U. et al. 2011. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. The FASEB Journal 25(6), pp. 1972-1982. (10.1096/fj.10-178517)
- Dewitt, S. and Hallett, M. B. 2011. Optical complexities of living cytoplasm - implications for live cell imaging and photo-micromanipulation techniques. Journal of Microscopy 241(3), pp. 221-224. (10.1111/j.1365-2818.2010.03451.x)
- Lewis, K., Dewitt, S. and Hallett, M. B. 2011. The role of calpain translocation in neutrophil spreading [Abstract]. European Journal of Clinical Investigation 41(s1), pp. 47. (10.1111/j.1365-2362.2011.02508.x)
- Ishak, R., Dewitt, S. and Hallett, M. B. 2011. Calpain-1: investigating its role in murine neutrophils [Abstract]. European Journal of Clinical Investigation 41(s1), pp. 24. (10.1111/j.1365-2362.2011.02508.x)
- Hallett, M. B. and Dewitt, S. 2011. A trick of the light: the optical properties of living cytoplasm which can mislead. Integrative Biology 3(3), pp. 180-184. (10.1039/c0ib00039f)
- Elumalai, G. L., Dewitt, S. and Hallett, M. B. 2011. Ezrin and talin relocates from the plasma membrane to cytosol during neutrophil extravasation [Abstract]. European Journal of Clinical Investigation 41(s1), pp. 47. (10.1111/j.1365-2362.2011.02508.x)
- Brasen, J. C., Dewitt, S. and Hallett, M. B. 2010. A reporter of UV intensity delivered to the cytosol during photolytic uncaging. Biophysical Journal 98(7), pp. L25-L27. (10.1016/j.bpj.2009.12.4271)
- Dewitt, S., Darley, R. L. and Hallett, M. B. 2009. Translocation or just location? Pseudopodia affect fluorescent signals. Journal of Cell Biology 184(2), pp. 197-203. (10.1083/jcb.200806047)
- Hallett, M. . B., Von Ruhland, C. J. and Dewitt, S. 2008. Chemotaxis and the cell surface-area problem [Letter]. Nature Reviews Molecular Cell Biology 9(8), pp. 662. (10.1038/nrm2419-c1)
- Dewitt, S. and Hallett, M. B. 2007. Leukocyte membrane 'expansion': a central mechanism for leukocyte extravasation. Journal of leukocyte biology 81(5), pp. 1160-1164. (10.1189/jlb.1106710)
- Hallett, M. B., Dewitt, S. and Tian, W. 2006. Localised PtdIns(3,4,5)P3 or PtdIns(3,4)P2 at the phagocytic cup is required for both phagosome closure and Ca2+ signalling in HL60 neutrophils. Journal of Cell Science 119(3), pp. 443-51. (10.1242/jcs.02756)
- Ayub, K., Laffaffian, I., Dewitt, S. and Hallett, M. B. 2004. Ca2+ influx shutdown in neutrophils induced by Fas (CD95) cross-linking. Immunology 112(3), pp. 454-460. (10.1111/j.1365-2567.2004.01899.x)
- Clayton, A., Turkes, A., Dewitt, S., Steadman, R., Mason, M. D. and Hallett, M. B. 2004. Adhesion and signaling by B cell-derived exosomes: the role of integrins. The FASEB Journal 18, pp. 977-979. (10.1096/fj.03-1094fje)
- Tian, W., Laffafian, I., Dewitt, S. and Hallett, M. B. 2003. Exclusion of exogenous phosphatidylinositol-3,4,5-trisphosphate from neutrophil-polarizing pseudopodia: stabilization of the uropod and cell polarity. EMBO Reports 4(10), pp. 982-988. (10.1038/sj.embor.embor947)
- Hallett, M. B., Laffafian, I. and Dewitt, S. 2003. Phagosomal oxidative activity during beta2 integrin (CR3)-mediated phagocytosis by neutrophils is triggered by a non-restricted Ca2+ signal: Ca2+ controls time not space. Journal of Cell Science 116(14), pp. 2857-65. (10.1242/jcs.00499)
- Hallett, M. B. and Dewitt, S. 2002. Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophils. The Journal of Cell Biology 159(1), pp. 181-9. (10.1083/jcb.200206089)
- Dewitt, S., Francis, R. J. and Hallett, M. B. 2013. Ca2+ and calpain control membrane expansion during rapid cell spreading of neutrophils. Journal of Cell Science 126(20), pp. 4627-4635. (10.1242/jcs.124917)
- McDonald, J. U. et al. 2011. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. The FASEB Journal 25(6), pp. 1972-1982. (10.1096/fj.10-178517)
- Dewitt, S. and Hallett, M. B. 2011. Optical complexities of living cytoplasm - implications for live cell imaging and photo-micromanipulation techniques. Journal of Microscopy 241(3), pp. 221-224. (10.1111/j.1365-2818.2010.03451.x)
- Dewitt, S., Darley, R. L. and Hallett, M. B. 2009. Translocation or just location? Pseudopodia affect fluorescent signals. Journal of Cell Biology 184(2), pp. 197-203. (10.1083/jcb.200806047)
- Hallett, M. . B., Von Ruhland, C. J. and Dewitt, S. 2008. Chemotaxis and the cell surface-area problem [Letter]. Nature Reviews Molecular Cell Biology 9(8), pp. 662. (10.1038/nrm2419-c1)
Teaching
Dr Dewitt is involved in undergraduate and postgraduate teaching. She teaches on the Year 2 BDS Oral Ecosystems course, and leads lectures, practicals and Team-based learning sessions focussed around the early stages of tooth development.
Dr Dewitt is deputy leader of the MSc Oral Biology course, and leads one of the modules, 'Stem cells, Regenerative Medicine & Scientific Methods'. This module covers the cellular biology of stem cells from various sources, and their application for tissue repair and regeneration purposes, as well the laboratory techniques that are typically used to investigate such processes.
Biography
Career profile
1999: First degree in Pharmacology, UWCM
2003: PhD from the University of Wales College of Medicine, Cardiff (Phagocytosis by Neutrophils: The Roles of Ca2+)
2004; 2010: Wellcome Trust funded Postdoctoral role in the Neutrophil Signalling Group, Cardiff University to investigate the mechanisms of neutrophil function; Awarded a Wellcome Trust VIP award to further research in neutrophil phagocytosis. Successful co-applicant of a Wellcome Trust grant, investigating the role of calpain in the control of phagocytosis by neutrophils (with Prof. MB Hallett).
Successful co-applicant for a PhD studentship awarded by the MRC and British Lung Foundation as part of the MRC Capacity Building Studentship Competition (with Prof. MB Hallett).
2010: ARC Cardiff Academic Fellowship (Cardiff University, School of Dentistry) working with Prof Aeschlimann and the ARCBBC (now the 'Biomechanics and Bioengineering Research Centre Versus Arthritis') team, to develop biomarker assays that predict pathology, pain, inflammation and changes in joint function in musculoskeletal diseases
2015: Appointment to Lecturer in School of Dentistry, Cardiff University
Teaching profile
Postgraduate supervision:
PhD Supervision:
- Validation of a stem cell derived cartilage model for osteoarthritis research and drug screening
- Role of sensor protein in development of osteoarthritis
- Investigating a candidate biomarker of osteoarthritis: Role in pathogenesis and efficacy to diagnose disease
- Novel cancer drug regulates disintegrin and metalloproteinase (ADAM) activity in Head and Neck cancer
- Determining the role of ADAM15 in Head and Neck and other cancers
Undergraduate teaching:
Yr 2 BDS: Oral Ecosystems
Deputy course leader, lectures/practicals in:
Tooth Development
Dentine Structure
Dentine physiology and sensitivity
Dentine Structure & Dentine Pulp Complex (practical)
Amelogenesis (practical)
Enamel Structure
Postgraduate teaching:
MSc Oral Biology, DET066:Tissue Repair, Regeneration and Scientific Methods
Module leader, lectures, practical in:
Analysis of a Research Paper
Use of Antibodies in Research
Principles of Microscopy
Confocal microscopy (practical)
Supervisions
I am interested in supervising research students in the following areas:
- Novel biomarkers for arthritis
- In vitro cartilage tissue engineering to model arthritis
- Modulation of neutrophil signalling and behaviour
Current supervision
