![Arianna Di Florio](https://profiles-cardiff.imgix.net/attachments/671?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Arianna Di Florio
Professor, Division of Psychological Medicine and Clinical Neurosciences
Overview
I am a researcher and clinical psychiatrist.
Psychiatric disorders associated with changes in female sex hormones, such as those associated with the menstrual cycle, childbirth and transition to menopause, are a major public health issue and represent a unique opportunity to study the complex interplay between gender, sex and mental states. In my role at Cardiff University, I have set up the Reproductive Mental Health Clinical and Research Programme to study how genetic and environmental markers can help identify women at risk of psychiatric disorders in relation to changes in sex hormones and improve the current approach to diagnosis, prevention and treatment. The programme includes the European Research Council funded project "Genetic Architecture Of Sex Steroid-related Psychiatric Disorders" (GASSP), the first molecular genetic study of the psychiatric sensitivity to sex hormone changes.
At the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University I lead the bipolar disorder genomics research group. Together with the Bipolar Disorder Research Network, the centre has collected the largest cohort of people with bipolar disorder in the world and has made important contributions to the understanding of the genetic susceptibility underpinning the disorder.
Publication
2024
- Gordon-Smith, K., Perry, A., Di Florio, A., Craddock, N., Jones, I. and Jones, L. 2024. Associations between lifetime reproductive events among postmenopausal women with bipolar disorder. Archives of Women's Mental Health (10.1007/s00737-024-01533-2)
- Apsey, C., Di Florio, A. and Stawarz, K. 2024. Developing a mood and menstrual tracking app for people with Premenstrual Dysphoric Disorder: A user-centered design study. JMIR Formative Research (10.2196/59333)
- Gordon, J. et al. 2024. Suicidality should be considered for inclusion in the diagnostic criteria for PMDD. The Lancet Psychiatry (10.1016/S2215-0366(24)00288-8)
- Shitomi-Jones, L. M., Dolman, C., Jones, I., Kirov, G., Escott-Price, V., Legge, S. E. and Di Florio, A. 2024. Exploration of first onsets of mania, schizophrenia spectrum disorders and major depressive disorder in perimenopause. nature mental health 2(10), pp. 1161-1168. (10.1038/s44220-024-00292-4)
- Song, J. et al. 2024. Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder. Molecular Psychiatry 29, pp. 1941-1950. (10.1038/s41380-024-02448-1)
- Jonsson, L. et al. 2024. Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder. The American Journal of Psychiatry 181(7), pp. 620-629. (10.1176/appi.ajp.20230073)
- Dolman, C. et al. 2024. Hypersexuality in bipolar disorder: an overlooked symptom. The Lancet Psychiatry 11(6), pp. 405-406. (10.1016/S2215-0366(24)00093-2)
- Perry, A., Gordon-Smith, K., Lewis, K., Di Florio, A., Craddock, N., Jones, L. and Jones, I. 2024. Perinatal sleep disruption and postpartum psychosis in bipolar disorder: Findings from the UK BDRN Pregnancy Study. Journal of affective disorders 346, pp. 21-27. (10.1016/j.jad.2023.11.005)
2023
- Yang, J. M. K. et al. 2023. Postpartum psychosis: a public involvement perspective across three continents. Archives of Women's Mental Health 26, pp. 831-837. (10.1007/s00737-023-01347-8)
- Bramante, A. and Di Florio, A. 2023. A case – Control study of filicide/infanticide in 90 mothers. Archives of Women's Mental Health (10.1007/s00737-023-01401-5)
- Carr, C. et al. 2023. Sleep and postpartum psychosis: a narrative review of the existing literature. Journal of Clinical Medicine 12(24), article number: 7550. (10.3390/jcm12247550)
- Guintivano, J. et al. 2023. Meta-analyses of genome-wide association studies for postpartum depression. The American Journal of Psychiatry 180(12), pp. 884-895. (10.1176/appi.ajp.20230053)
- Di Florio, A., Apsey, C. and Eisenlohr-Moul, T. 2023. Etiologic studies of premenstrual disorders require prospective confirmation of affective cyclicity. JAMA Psychiatry 80(11), article number: 1175. (10.1001/jamapsychiatry.2023.3287)
- Munk-Olsen, T. et al. 2023. Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. Translational Psychiatry 13, article number: 346. (10.1038/s41398-023-02649-2)
- Munk-Olsen, T., Di Florio, A., Bergink, V., Agerbo, E., Madsen, K. B., Petersen, L. V. and Liu, X. 2023. Genetic liability to bipolar disorder and onset of postpartum mental disorders. BMJ Mental Health 26(1), article number: e300835. (10.1136/bmjment-2023-300835)
- Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
- Vaiphei, K., Yaresheemi, S., Yang, J. M. K., Di Florio, A., Chandra, P. S. and Thippeswamy, H. 2023. Formation of a stakeholder group of women with a lived experience of Post-partum Psychoses (PP) – Experience from a perinatal psychiatry service in India. Asian Journal of Psychiatry 84, article number: 103592. (10.1016/j.ajp.2023.103592)
- Lewis, K. et al. 2023. The dynamic interplay between sleep and mood: an intensive longitudinal study of individuals with bipolar disorder. Psychological Medicine 53(8), pp. 3345-3354. (10.1017/S0033291721005377)
- Casanova Dias, M. et al. 2023. Borderline personality traits are differently associated with postpartum psychosis and postpartum depression episodes in women with bipolar disorder. Journal of Affective Disorders 328, pp. 81-86. (10.1016/j.jad.2023.01.124)
2022
- Lewis, K. J. et al. 2022. Mental health prior to and during the COVID-19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data. Bipolar Disorders 24(6), pp. 658-666. (10.1111/bdi.13204)
- Richards, A. et al. 2022. Genetic liabilities differentiating bipolar disorder, schizophrenia and major depression and phenotypic heterogeneity in bipolar disorder. JAMA Psychiatry 79(10), pp. 1032-1039. (10.1001/jamapsychiatry.2022.2594)
- Palmer, D. et al. 2022. Exome sequencing in bipolar disorder reveals AKAP11 as a risk gene shared with schizophrenia. Nature Genetics (10.1038/s41588-022-01034-x)
2021
- Kalman, J. L. et al. 2021. Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry 219(6), pp. 659-669. (10.1192/bjp.2021.102)
- Di Florio, A. et al. 2021. Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores. The Lancet Psychiatry 8(12), pp. 1045-1052. (10.1016/S2215-0366(21)00253-4)
- Perry, A., Gordon-Smith, K., Di Florio, A., Craddock, N., Jones, L. and Jones, I. 2021. Mood episodes in pregnancy and risk of postpartum recurrence in bipolar disorder: The Bipolar Disorder Research Network Pregnancy Study. Journal of Affective Disorders 294, pp. 714-722. (10.1016/j.jad.2021.07.067)
- Jia, X. et al. 2021. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Molecular Psychiatry 26, pp. 5239-5250. (10.1038/s41380-020-01006-9)
- Clifton, N. E. et al. 2021. Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry 90(6) (10.1016/j.biopsych.2021.03.009)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Clifton, N. E. et al. 2021. Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry 26, pp. 2977-2990. (10.1038/s41380-020-00912-2)
- Mullins, N. et al. 2021. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics 53, pp. 817-829. (10.1038/s41588-021-00857-4)
- Saunders, K. E. A. et al. 2021. The influence of borderline personality traits on clinical outcomes in bipolar disorder. Bipolar Disorders 23(4), pp. 368-375. (10.1111/bdi.12978)
2020
- Gordon-Smith, K. et al. 2020. Patterns and clinical correlates of lifetime alcohol consumption in women and men with bipolar disorder: Findings from the UK Bipolar Disorder Research Network. Bipolar Disorders 22(7), pp. 731-738. (10.1111/bdi.12905)
- Soda, T. et al. 2020. International consortium on the genetics of electroconvulsive therapy and severe depressive disorders (Gen-ECT-ic). European Archives of Psychiatry and Clinical Neuroscience 270, pp. 921-932. (10.1007/s00406-019-01087-w)
- Marwaha, S. et al. 2020. Explaining why childhood abuse is a risk factor for poorer clinical course in bipolar disorder: a path analysis of 923 people with bipolar I disorder. Psychological Medicine 50(14), pp. 2346-2354. (10.1017/S0033291719002411)
- Sharma, V. et al. 2020. Primacy of (hypo) mania in the postpartum period: a concept worth considering. Bipolar Disorders 22(6), pp. 553-555. (10.1111/bdi.12988)
- Akingbuwa, W. A. et al. 2020. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals. JAMA Psychiatry 77(7), pp. 715-728. (10.1001/jamapsychiatry.2020.0527)
- Lewis, K. J. et al. 2020. Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants. JAMA Psychiatry 77(3), pp. 303-310. (10.1001/jamapsychiatry.2019.4079)
- Gordon-Smith, K. et al. 2020. Symptom profile of postpartum and non-postpartum manic episodes in bipolar I disorder: a within-subjects study. Psychiatry Research 284, article number: 112748. (10.1016/j.psychres.2020.112748)
- Perry, A., Gordon-Smith, K., Di Florio, A., Fraser, C., Craddock, N., Jones, L. and Jones, I. 2020. Adverse childhood experiences and postpartum depression in bipolar disorder. Journal of Affective Disorders 263, pp. 661-666. (10.1016/j.jad.2019.11.042)
2019
- Luykx, J., Di Florio, A. and Bergink, V. 2019. Prevention of infanticide and suicide in the postpartum period: the importance of emergency care. JAMA Psychiatry 76(12), pp. 1221-1222. (10.1001/jamapsychiatry.2019.1929)
- Perry, A. et al. 2019. Postpartum psychosis in bipolar disorder: no evidence of association with personality traits, cognitive style or affective temperaments. BMC Psychiatry 19(1), article number: 395. (10.1186/s12888-019-2392-0)
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Mistry, S., Escott-Price, V., Di Florio, A., Smith, D. and Zammit, S. 2019. Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood. Journal of Affective Disorders 259, pp. 112-120. (10.1016/j.jad.2019.08.040)
- Serra, F. et al. 2019. Agitated depression in bipolar disorder. Bipolar Disorders 21(6), pp. 547-555. (10.1111/bdi.12778)
- Di Florio, A. et al. 2019. Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum. British Journal of Psychiatry 213(3), pp. 542-547. (10.1192/bjp.2018.92)
- Charney, A. W. et al. 2019. Contribution of rare copy number variants to bipolar disorder risk Is limited to schizoaffective cases. Biological Psychiatry 86(2), pp. 110-119. (10.1016/j.biopsych.2018.12.009)
- Stahl, E. A. et al. 2019. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics 51, pp. 793-803. (10.1038/s41588-019-0397-8)
- Mistry, S., Escott-Price, V., Di Florio, A., Smith, D. J. and Zammit, S. 2019. Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood. Journal of Affective Disorders 246, pp. 633-639. (10.1016/j.jad.2018.12.091)
- Yu, H., Chapman, B., Di Florio, A., Eischen, E., Gotz, D., Jacob, M. and Blair, R. H. 2019. Bootstrapping estimates of stability for clusters, observations and model selection. Computational Statistics 34(1), pp. 349-372. (10.1007/s00180-018-0830-y)
- Clifton, N. E. et al. 2019. Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry 9, article number: 74. (10.1038/s41398-019-0405-x)
2018
- Hidalgo-Mazzei, D. et al. 2018. Treatment-resistant and Multi-therapy resistant criteria for bipolar depression: consensus definition. British Journal of Psychiatry (10.1192/bjp.2018.257)
- Di Florio, A., Alexander, D., Schmidt, P. J. and Rubinow, D. R. 2018. Progesterone and plasma metabolites in women with and in those without premenstrual dysphoric disorder. Depression and Anxiety 35(12), pp. 1168-1177. (10.1002/da.22827)
- Munk-Olsen, T. et al. 2018. Maternal and infant outcomes associated with lithium use in pregnancy. Lancet Psychiatry 5(8), pp. 644-652. (10.1016/S2215-0366(18)30180-9)
- Ruderfer, D. M. et al. 2018. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173(7), pp. 1705-1715.e16. (10.1016/j.cell.2018.05.046)
- Leonenko, G. et al. 2018. A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(4), pp. 468-475. (10.1002/ajmg.b.32635)
- Meltzer-Brody, S. et al. 2018. Adverse life events increase risk for postpartum psychiatric episodes: a population based epidemiologic study. Depression and Anxiety 35(2), pp. 160-167. (10.1002/da.22697)
- Allardyce, J. et al. 2018. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75(1), pp. 28-35. (10.1001/jamapsychiatry.2017.3485)
- Lewis, K. et al. 2018. Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. Journal of Affective Disorders 225, pp. 624-629. (10.1016/j.jad.2017.08.054)
2017
- Green, E. K. et al. 2017. Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(8), pp. 767-771. (10.1002/ajmg.b.32572)
- Lewis, K., Gordon-Smith, K., Forty, L., Di Florio, A., Craddock, N., Jones, L. and Jones, I. 2017. Sleep loss as a trigger of mood episodes in bipolar disorder: individual differences based on diagnostic subtype and gender. British Journal of Psychiatry 211(3), pp. 169-174. (10.1192/bjp.bp.117.202259)
- Lara-Cinisomo, S., McKenney, K., Di Florio, A. and Meltzer-Brody, S. 2017. Associations between postpartum depression, breastfeeding, and oxytocin levels in Latina mothers. Breastfeeding Medicine 12(7), pp. 436-442. (10.1089/bfm.2016.0213)
- Allardyce, J. et al. 2017. Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia. [Online]. bioRxiv. Available at: http://dx.doi.org/10.1101/160119
- Witt, S. H. et al. 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression. Translational Psychiatry 7, article number: e1155.
- Putnam, K. T. et al. 2017. Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium. The Lancet Psychiatry 4(6), pp. 477-485. (10.1016/S2215-0366(17)30136-0)
- Ferguson, E. H., Di Florio, A., Pearson, B., Putnam, K. T., Girdler, S., Rubinow, D. R. and Meltzer-Brody, S. 2017. HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression. Archives of Women's Mental Health 20(3), pp. 411-420. (10.1007/s00737-017-0716-y)
- Di Florio, A. et al. 2017. The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale. Psychological Medicine 47(5), pp. 787-799. (10.1017/S0033291716002087)
- Charney, A. W. et al. 2017. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Translational Psychiatry 7(1), pp. e993. (10.1038/tp.2016.242)
2016
- Perry, A., Gordon-Smith, K., Di Florio, A., Forty, E., Craddock, N. J., Jones, L. and Jones, I. R. 2016. Adverse childhood life events and postpartum psychosis in bipolar disorder. Journal of affective disorders 205, pp. 69-72. (10.1016/j.jad.2016.06.061)
- Munk-Olsen, T. et al. 2016. Perinatal psychiatric episodes: a population-based study on treatment incidence and prevalence. Translational Psychiatry 6, article number: e919. (10.1038/tp.2016.190)
- Song, J. et al. 2016. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Molecular Psychiatry 2016, pp. 1290-1297. (10.1038/mp.2015.165)
- Kimmel, M. C., Lara-Cinisomo, S., Melvin, K., Di Florio, A., Brandon, A. and Meltzer-Brody, S. 2016. Treatment of severe perinatal mood disorders on a specialized perinatal psychiatry inpatient unit. Archives of Women's Mental Health 19, article number: 645. (10.1007/s00737-016-0599-3)
- Di Florio, A., Munk-Olsen, T. and Bergink, V. 2016. The birth of a psychiatric orphan disorder: postpartum psychosis [Correspondence]. The Lancet Psychiatry 3(6), pp. 502. (10.1016/S2215-0366(16)30037-2)
2015
- Singh, S. et al. 2015. Affective temperaments and concomitant alcohol use disorders in bipolar disorder. Journal of affective disorders 186, pp. 226-231. (10.1016/j.jad.2015.07.027)
- Di Florio, A. and Meltzer-Brody, S. 2015. Is postpartum depression a distinct disorder?. Current Psychiatry Reports 17(10), article number: 76. (10.1007/s11920-015-0617-6)
- Di Florio, A., Morgan, H., Jones, L., Forty, E., Gordon-Smith, K., Craddock, N. J. and Jones, I. R. 2015. Smoking and postpartum psychosis. Bipolar Disorders 17(5), pp. 572-573. (10.1111/bdi.12314)
- Castro, V. M. et al. 2015. Validation of electronic health record phenotyping of bipolar disorder cases and controls. American Journal of Psychiatry 172(4), pp. 363-372. (10.1176/appi.ajp.2014.14030423)
- Di Florio, A., Jones, L., Forty, E., Gordon-Smith, K., Craddock, N. J. and Jones, I. R. 2015. Bipolar disorder, miscarriage, and termination. Bipolar Disorders 17(1), pp. 102-105. (10.1111/bdi.12217)
- Pigato, G., Piazzon, G. V. M., Di Florio, A., Ermani, M., Toffanin, T. and Perini, G. I. 2015. Early hyperprolactinaemia in acute psychiatric inpatients: a cross-sectional study. Journal of Psychopathology 21(3), pp. 226-230.
2014
- Di Florio, A., Jones, L., Forty, E., Gordon-Smith, K., Craddock, N. J. and Jones, I. R. 2014. Postpartum bipolar depression in a clinical sample of 1721 parous women with mood disorders [Conference Abstract]. Bipolar Disorders 16(S1), pp. 62-62. (10.1111/bdi.12188)
- Di Florio, A., Craddock, N. J. and van den Bree, M. B. 2014. Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates. European Psychiatry 29(3), pp. 117-24. (10.1016/j.eurpsy.2013.07.004)
- Di Florio, A. et al. 2014. Mood disorders and parity - A clue to the aetiology of the postpartum trigger. Journal of affective disorders 152-15, pp. 334-339. (10.1016/j.jad.2013.09.034)
2013
- Di Florio, A. et al. 2013. Perinatal episodes across the mood disorder spectrum. JAMA Psychiatry 70(2), pp. 168-175. (10.1001/jamapsychiatry.2013.279)
- Di Florio, A., Smith, S. and Jones, I. R. 2013. Postpartum psychosis. The Obstetrician & Gynaecologist 15(3), pp. 145-150. (10.1111/tog.12041)
- Di Florio, A. and Craddock, N. J. 2013. The genomics revolution in psychiatry: a lesson from bipolar disorder. Dusunen Adam 26(2), pp. 119-121. (10.5350/DAJPN20132602001)
2012
- Di Florio, A. 2012. Bipolar disorder in pregnancy and the postpartum. PhD Thesis, Cardiff University.
2011
- Smith, D. J. et al. 2011. Beating bipolar: exploratory trial of a novel internet-based psychoeducational treatment for bipolar disorder. Bipolar Disorders 13(5-6), pp. 571-577. (10.1111/j.1399-5618.2011.00949.x)
2010
- Di Florio, A. and Jones, I. R. 2010. Is sex important? Gender differences in bipolar disorder. International Review of Psychiatry 22(5), pp. 437-452. (10.3109/09540261.2010.514601)
- Di Florio, A. et al. 2010. Affective temperaments across the bipolar-unipolar spectrum: examination of the TEMPS-A in 927 patients and controls. Journal of affective disorders 123(1-3), pp. 42-51. (10.1016/j.jad.2009.09.020)
2009
- Pigato, G., Toffanin, T., Ferri, G., Di Florio, A., Giannunzio, V. and Perini, G. 2009. Studio naturalistico di confronto tra due strategie di dosaggio iniziale di duloxetina in un contesto clinico “real world". Rivista di Psichiatria 44(6), pp. 1-9. (10.1708/468.5538)
2008
- Perini, G. I., Di Florio, A. and Pavan, C. 2008. Major depressive disorders and coronary artery disease: a review on common pathophysiological pathways. Clinical Neuropsychiatry 5(3), pp. 151-161.
Articles
- Gordon-Smith, K., Perry, A., Di Florio, A., Craddock, N., Jones, I. and Jones, L. 2024. Associations between lifetime reproductive events among postmenopausal women with bipolar disorder. Archives of Women's Mental Health (10.1007/s00737-024-01533-2)
- Apsey, C., Di Florio, A. and Stawarz, K. 2024. Developing a mood and menstrual tracking app for people with Premenstrual Dysphoric Disorder: A user-centered design study. JMIR Formative Research (10.2196/59333)
- Gordon, J. et al. 2024. Suicidality should be considered for inclusion in the diagnostic criteria for PMDD. The Lancet Psychiatry (10.1016/S2215-0366(24)00288-8)
- Shitomi-Jones, L. M., Dolman, C., Jones, I., Kirov, G., Escott-Price, V., Legge, S. E. and Di Florio, A. 2024. Exploration of first onsets of mania, schizophrenia spectrum disorders and major depressive disorder in perimenopause. nature mental health 2(10), pp. 1161-1168. (10.1038/s44220-024-00292-4)
- Song, J. et al. 2024. Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder. Molecular Psychiatry 29, pp. 1941-1950. (10.1038/s41380-024-02448-1)
- Jonsson, L. et al. 2024. Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder. The American Journal of Psychiatry 181(7), pp. 620-629. (10.1176/appi.ajp.20230073)
- Dolman, C. et al. 2024. Hypersexuality in bipolar disorder: an overlooked symptom. The Lancet Psychiatry 11(6), pp. 405-406. (10.1016/S2215-0366(24)00093-2)
- Perry, A., Gordon-Smith, K., Lewis, K., Di Florio, A., Craddock, N., Jones, L. and Jones, I. 2024. Perinatal sleep disruption and postpartum psychosis in bipolar disorder: Findings from the UK BDRN Pregnancy Study. Journal of affective disorders 346, pp. 21-27. (10.1016/j.jad.2023.11.005)
- Yang, J. M. K. et al. 2023. Postpartum psychosis: a public involvement perspective across three continents. Archives of Women's Mental Health 26, pp. 831-837. (10.1007/s00737-023-01347-8)
- Bramante, A. and Di Florio, A. 2023. A case – Control study of filicide/infanticide in 90 mothers. Archives of Women's Mental Health (10.1007/s00737-023-01401-5)
- Carr, C. et al. 2023. Sleep and postpartum psychosis: a narrative review of the existing literature. Journal of Clinical Medicine 12(24), article number: 7550. (10.3390/jcm12247550)
- Guintivano, J. et al. 2023. Meta-analyses of genome-wide association studies for postpartum depression. The American Journal of Psychiatry 180(12), pp. 884-895. (10.1176/appi.ajp.20230053)
- Di Florio, A., Apsey, C. and Eisenlohr-Moul, T. 2023. Etiologic studies of premenstrual disorders require prospective confirmation of affective cyclicity. JAMA Psychiatry 80(11), article number: 1175. (10.1001/jamapsychiatry.2023.3287)
- Munk-Olsen, T. et al. 2023. Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. Translational Psychiatry 13, article number: 346. (10.1038/s41398-023-02649-2)
- Munk-Olsen, T., Di Florio, A., Bergink, V., Agerbo, E., Madsen, K. B., Petersen, L. V. and Liu, X. 2023. Genetic liability to bipolar disorder and onset of postpartum mental disorders. BMJ Mental Health 26(1), article number: e300835. (10.1136/bmjment-2023-300835)
- Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
- Vaiphei, K., Yaresheemi, S., Yang, J. M. K., Di Florio, A., Chandra, P. S. and Thippeswamy, H. 2023. Formation of a stakeholder group of women with a lived experience of Post-partum Psychoses (PP) – Experience from a perinatal psychiatry service in India. Asian Journal of Psychiatry 84, article number: 103592. (10.1016/j.ajp.2023.103592)
- Lewis, K. et al. 2023. The dynamic interplay between sleep and mood: an intensive longitudinal study of individuals with bipolar disorder. Psychological Medicine 53(8), pp. 3345-3354. (10.1017/S0033291721005377)
- Casanova Dias, M. et al. 2023. Borderline personality traits are differently associated with postpartum psychosis and postpartum depression episodes in women with bipolar disorder. Journal of Affective Disorders 328, pp. 81-86. (10.1016/j.jad.2023.01.124)
- Lewis, K. J. et al. 2022. Mental health prior to and during the COVID-19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data. Bipolar Disorders 24(6), pp. 658-666. (10.1111/bdi.13204)
- Richards, A. et al. 2022. Genetic liabilities differentiating bipolar disorder, schizophrenia and major depression and phenotypic heterogeneity in bipolar disorder. JAMA Psychiatry 79(10), pp. 1032-1039. (10.1001/jamapsychiatry.2022.2594)
- Palmer, D. et al. 2022. Exome sequencing in bipolar disorder reveals AKAP11 as a risk gene shared with schizophrenia. Nature Genetics (10.1038/s41588-022-01034-x)
- Kalman, J. L. et al. 2021. Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry 219(6), pp. 659-669. (10.1192/bjp.2021.102)
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- Luykx, J., Di Florio, A. and Bergink, V. 2019. Prevention of infanticide and suicide in the postpartum period: the importance of emergency care. JAMA Psychiatry 76(12), pp. 1221-1222. (10.1001/jamapsychiatry.2019.1929)
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- Mistry, S., Escott-Price, V., Di Florio, A., Smith, D. and Zammit, S. 2019. Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood. Journal of Affective Disorders 259, pp. 112-120. (10.1016/j.jad.2019.08.040)
- Serra, F. et al. 2019. Agitated depression in bipolar disorder. Bipolar Disorders 21(6), pp. 547-555. (10.1111/bdi.12778)
- Di Florio, A. et al. 2019. Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum. British Journal of Psychiatry 213(3), pp. 542-547. (10.1192/bjp.2018.92)
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- Mistry, S., Escott-Price, V., Di Florio, A., Smith, D. J. and Zammit, S. 2019. Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood. Journal of Affective Disorders 246, pp. 633-639. (10.1016/j.jad.2018.12.091)
- Yu, H., Chapman, B., Di Florio, A., Eischen, E., Gotz, D., Jacob, M. and Blair, R. H. 2019. Bootstrapping estimates of stability for clusters, observations and model selection. Computational Statistics 34(1), pp. 349-372. (10.1007/s00180-018-0830-y)
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- Hidalgo-Mazzei, D. et al. 2018. Treatment-resistant and Multi-therapy resistant criteria for bipolar depression: consensus definition. British Journal of Psychiatry (10.1192/bjp.2018.257)
- Di Florio, A., Alexander, D., Schmidt, P. J. and Rubinow, D. R. 2018. Progesterone and plasma metabolites in women with and in those without premenstrual dysphoric disorder. Depression and Anxiety 35(12), pp. 1168-1177. (10.1002/da.22827)
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- Lewis, K. et al. 2018. Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. Journal of Affective Disorders 225, pp. 624-629. (10.1016/j.jad.2017.08.054)
- Green, E. K. et al. 2017. Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(8), pp. 767-771. (10.1002/ajmg.b.32572)
- Lewis, K., Gordon-Smith, K., Forty, L., Di Florio, A., Craddock, N., Jones, L. and Jones, I. 2017. Sleep loss as a trigger of mood episodes in bipolar disorder: individual differences based on diagnostic subtype and gender. British Journal of Psychiatry 211(3), pp. 169-174. (10.1192/bjp.bp.117.202259)
- Lara-Cinisomo, S., McKenney, K., Di Florio, A. and Meltzer-Brody, S. 2017. Associations between postpartum depression, breastfeeding, and oxytocin levels in Latina mothers. Breastfeeding Medicine 12(7), pp. 436-442. (10.1089/bfm.2016.0213)
- Witt, S. H. et al. 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression. Translational Psychiatry 7, article number: e1155.
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- Ferguson, E. H., Di Florio, A., Pearson, B., Putnam, K. T., Girdler, S., Rubinow, D. R. and Meltzer-Brody, S. 2017. HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression. Archives of Women's Mental Health 20(3), pp. 411-420. (10.1007/s00737-017-0716-y)
- Di Florio, A. et al. 2017. The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale. Psychological Medicine 47(5), pp. 787-799. (10.1017/S0033291716002087)
- Charney, A. W. et al. 2017. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Translational Psychiatry 7(1), pp. e993. (10.1038/tp.2016.242)
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- Song, J. et al. 2016. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Molecular Psychiatry 2016, pp. 1290-1297. (10.1038/mp.2015.165)
- Kimmel, M. C., Lara-Cinisomo, S., Melvin, K., Di Florio, A., Brandon, A. and Meltzer-Brody, S. 2016. Treatment of severe perinatal mood disorders on a specialized perinatal psychiatry inpatient unit. Archives of Women's Mental Health 19, article number: 645. (10.1007/s00737-016-0599-3)
- Di Florio, A., Munk-Olsen, T. and Bergink, V. 2016. The birth of a psychiatric orphan disorder: postpartum psychosis [Correspondence]. The Lancet Psychiatry 3(6), pp. 502. (10.1016/S2215-0366(16)30037-2)
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- Di Florio, A., Morgan, H., Jones, L., Forty, E., Gordon-Smith, K., Craddock, N. J. and Jones, I. R. 2015. Smoking and postpartum psychosis. Bipolar Disorders 17(5), pp. 572-573. (10.1111/bdi.12314)
- Castro, V. M. et al. 2015. Validation of electronic health record phenotyping of bipolar disorder cases and controls. American Journal of Psychiatry 172(4), pp. 363-372. (10.1176/appi.ajp.2014.14030423)
- Di Florio, A., Jones, L., Forty, E., Gordon-Smith, K., Craddock, N. J. and Jones, I. R. 2015. Bipolar disorder, miscarriage, and termination. Bipolar Disorders 17(1), pp. 102-105. (10.1111/bdi.12217)
- Pigato, G., Piazzon, G. V. M., Di Florio, A., Ermani, M., Toffanin, T. and Perini, G. I. 2015. Early hyperprolactinaemia in acute psychiatric inpatients: a cross-sectional study. Journal of Psychopathology 21(3), pp. 226-230.
- Di Florio, A., Jones, L., Forty, E., Gordon-Smith, K., Craddock, N. J. and Jones, I. R. 2014. Postpartum bipolar depression in a clinical sample of 1721 parous women with mood disorders [Conference Abstract]. Bipolar Disorders 16(S1), pp. 62-62. (10.1111/bdi.12188)
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- Di Florio, A. et al. 2014. Mood disorders and parity - A clue to the aetiology of the postpartum trigger. Journal of affective disorders 152-15, pp. 334-339. (10.1016/j.jad.2013.09.034)
- Di Florio, A. et al. 2013. Perinatal episodes across the mood disorder spectrum. JAMA Psychiatry 70(2), pp. 168-175. (10.1001/jamapsychiatry.2013.279)
- Di Florio, A., Smith, S. and Jones, I. R. 2013. Postpartum psychosis. The Obstetrician & Gynaecologist 15(3), pp. 145-150. (10.1111/tog.12041)
- Di Florio, A. and Craddock, N. J. 2013. The genomics revolution in psychiatry: a lesson from bipolar disorder. Dusunen Adam 26(2), pp. 119-121. (10.5350/DAJPN20132602001)
- Smith, D. J. et al. 2011. Beating bipolar: exploratory trial of a novel internet-based psychoeducational treatment for bipolar disorder. Bipolar Disorders 13(5-6), pp. 571-577. (10.1111/j.1399-5618.2011.00949.x)
- Di Florio, A. and Jones, I. R. 2010. Is sex important? Gender differences in bipolar disorder. International Review of Psychiatry 22(5), pp. 437-452. (10.3109/09540261.2010.514601)
- Di Florio, A. et al. 2010. Affective temperaments across the bipolar-unipolar spectrum: examination of the TEMPS-A in 927 patients and controls. Journal of affective disorders 123(1-3), pp. 42-51. (10.1016/j.jad.2009.09.020)
- Pigato, G., Toffanin, T., Ferri, G., Di Florio, A., Giannunzio, V. and Perini, G. 2009. Studio naturalistico di confronto tra due strategie di dosaggio iniziale di duloxetina in un contesto clinico “real world". Rivista di Psichiatria 44(6), pp. 1-9. (10.1708/468.5538)
- Perini, G. I., Di Florio, A. and Pavan, C. 2008. Major depressive disorders and coronary artery disease: a review on common pathophysiological pathways. Clinical Neuropsychiatry 5(3), pp. 151-161.
Thesis
- Di Florio, A. 2012. Bipolar disorder in pregnancy and the postpartum. PhD Thesis, Cardiff University.
Websites
- Allardyce, J. et al. 2017. Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia. [Online]. bioRxiv. Available at: http://dx.doi.org/10.1101/160119
Research
Research Grants and Fellowships
2021-2026 European Research Council Starting Grant, ”Genetic Architecture of Sex Steroid-related Psychiatric disorders”, (PI) 1,500,000 Euro
2021-2024 Medical Research Council, "Perimenopause and risk of psychiatric disorders: a longitudinal, population-based study”, (PI), 534,657.23 GBP
2021 Global Challenge Research Fund, Small Projects, ”A Cross Cultural study of Motherhood and Mental health”, (PI) 37,734 GBP
2020-2025 Health and Care Research Wales, ”The National Centre for Mental Health”, (co-I) 4,950,000 GBP
2019-2022 Wellcome Trust, ”Feasibility of a large-scale, international, clinical-genetic study of postpartum psychosis”, (PI) 89,126 GBP
2019-2021 Brain & Behavior Research Foundation NARSAD Young Investigator Award, ”Systematic investigation of the ge- netic susceptibility to sleep disturbance in bipolar disorder”, (PI) 70,000 USD
2018-2021 Medical Research Council Project Grant; ”Individualising the risk of re- currence for women with bipolar disorder in the perinatal period”, (co-I) 264,655 GBP
2014-2017 European Commission Marie Curie Actions International Outgoing Fellow- ships; ”Postpartum BiD - Improving prediction of the triggering of bipolar disorder episodes by childbirth”, (PI) 282,109 Euro
2015-2016 United States National Science Foundation - Division Of Mathematical Sciences; ”Interactive Ensemble clustering for mixed data with application to mood disorders”, (co-I) 99,998 USD
2010-2012 Health and Care Research Wales, Welsh Assembly Government Health Studentship Award; ”A prospective study of bipolar disorder in pregnancy and the postpartum”, (co-PI) 58,585 GBP
Biography
Current posts
2021- Professor of Psychiatry, Division of Psychological Medicine and Clinical Neuroscience, Cardiff University, United Kingdom
2017- Consultant Psychiatrist, Cardiff and Vale University Health Board, Cardiff
2016- Adjunct Assistant Professor, University of North Carolina at Chapel Hill, United States
Other Roles and Responsibilities
2019- Chair, International Postpartum Psychosis Consortium
2019- Clinical Lead and Outreach officer, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
2019- Steering committee member, Bipolar Disorder Sequencing Consortium
2017- Clinical Lead for Undergraduate Psychiatry, Cardiff University Medical School
Previous posts
2017- CLINICAL SENIOR LECTURER, Division of Psychological Medicine and Clinical Neuroscience, Cardiff University
2014-2016 MARIE SKŁODOWSKA-CURIE FELLOW, University of North Carolina at Chapel Hill, United States
2014 SPECIALIST IN PSYCHIATRY, Cardiff & Vale University Health Board
2013-2014 CLINICAL RESEARCH FELLOW, MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences
2010-2012 PHD STUDENT, Cardiff University
2009 VISITING CLINICAL RESEARCHER, MRC Centre for Neuropsychiatric Genetics and Genomics
2006-2010 RESIDENT IN PSYCHIATRY, Clinica Psichiatrica-Azienda Ospedaliera, Padova, Italy
2005 VISITING RESEARCH STUDENT, Max Delbrück Centre for Molecular Medicine Berlin-Buch, Neuronal Stem Cells group, Germany
Education
2013 Doctor of Philosophy, Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, United Kingdom
2010 Specialist in Psychiatry, Clinica Psichiatrica- Azienda Ospedaliera USLL 16, Padua, Italy
2005 Doctor of Medicine, Clinica Psichiatrica- Azienda Ospedaliera USLL 16, Padua, Italy
Contact Details
DiFlorioA@cardiff.ac.uk
+44 29206 88382
Hadyn Ellis Building, Room 2.12, Maindy Road, Cardiff, CF24 4HQ
+44 29206 88382
Hadyn Ellis Building, Room 2.12, Maindy Road, Cardiff, CF24 4HQ
