Dr Irina Guschina

2025

• Smith, K. A. et al. 2025. Helminth-induced prostaglandin signalling and dietary shifts in PUFA metabolism promote colitis-associated cancer. Journal of Lipid Research 66(7), article number: 100837. (10.1016/j.jlr.2025.100837)

2023

• Richter, F. C. et al. 2023. Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL‐10. The EMBO Journal, pp. e112202. (10.15252/embj.2022112202)

2022

• Palyzová, A., Guschina, I. A. and Řezanka, T. 2022. Chiral analysis of glycerol phosphates - Can bacteria biosynthesize heterochiral phospholipid membranes?. Journal of Chromatography A 1676, article number: 463267. (10.1016/j.chroma.2022.463267)

2021

• Guschina, I. A. and Harwood, J. L. 2021. Chemical diversity of lipids. In: Encyclopedia of Biophysics. Springer, (10.1007/978-3-642-35943-9_526-1)
• Guschina, I. A., Ninkina, N., Roman, A., Pokrovskiy, M. V. and Buchman, V. L. 2021. Triple-knockout, synuclein-free mice display compromised lipid pattern. Molecules 26(11), article number: 3078. (10.3390/molecules26113078)

2020

• Guschina, I. A., Hayes, A. J. and Ormerod, S. J. 2020. Polystyrene microplastics decrease accumulation of essential fatty acids in common freshwater algae. Environmental Pollution 263(PartB), article number: 114425. (10.1016/j.envpol.2020.114425)

2019

• Woodfield, H. K. et al. 2019. Increase in lysophosphatidate acyltransferase activity in oilseed rape (Brassica napus) increases seed triacylglycerol content despite its low intrinsic flux control coefficient. New Phytologist 224(2), pp. 700-711. (10.1111/nph.16100)
• Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)

2018

• Guschina, I. A. and Harwood, J. L. 2018. Strategies for the analysis of plant lipids. In: Encyclopedia of Analytical Chemistry. John Wiley & Sons, Ltd., (10.1002/9780470027318.a9920.pub2)
• Pope, I. et al. 2018. Coherent Raman Scattering microscopy: technology developments and biological applications. Presented at: 20th International Conference on Transparent Optical Networks (ICTON), Bucharest, Romania, 1-5 Jul 201820th International Conference on Transparent Optical Networks (ICTON). IEEE, (10.1109/ICTON.2018.8473706)
• Woodfield, H. K., Cazenave-Gassiot, A., Haslam, R. P., Guschina, I. A., Wenk, M. R. and Harwood, J. L. 2018. Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.). Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(3) (10.1016/j.bbalip.2017.12.010)

2017

• Woodfield, H. K., Sturtevant, D., Borisjuk, L., Munz, E., Guschina, I. A., Chapman, K. and Harwood, J. L. 2017. Spatial and temporal mapping of key lipid species in Brassica napus seeds. Plant Physiology 173(4), pp. 1998-2009. (10.1104/pp.16.01705)
• Hopkins, A. L. et al. 2017. Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target-cell-induced acylation. Scientific Reports 7, article number: 45541. (10.1038/srep45541)
• Golding, D. M. et al. 2017. Paradoxical leanness in the imprinting-centre deletion mouse model for Prader–Willi syndrome. Journal of Endocrinology 232(1), pp. 123-135. (10.1530/JOE-16-0367)

2016

• Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
• Wacker, A., Piepho, M., Harwood, J. L., Guschina, I. and Arts, M. T. 2016. Light-induced changes in fatty acid profiles of specific lipid classes in several freshwater phytoplankton species. Frontiers in Plant Science 7, article number: 264. (10.3389/fpls.2016.00264)

2015

• Guschina, I., Everard, J. D., Kinney, A. J., Quant, P. A. and Harwood, J. L. 2015. Erratum to ‘Studies on the regulation of lipid biosynthesis in plants: Application of control analysis to soybean’ [Biochim. Biophys. Acta 1838 (2014) 1488–1500]. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848(1), pp. 104. (10.1016/j.bbamem.2014.10.011)
• Tsurkan, Y., Karpenyuk, T., Guschina, I., Orazova, S., Goncharova, A. and Beisembaeva, R. 2015. Identification of newly-isolated microorganisms containing valuable polyunsaturated fatty acids. Journal of Biotech Research 6, pp. 14-20.

2014

• Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29(12), pp. 2756-2763. (10.1093/humrep/deu281)
• Connolly, K. D. et al. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55, pp. 2064-2072. (10.1194/jlr.M049726)
• Berube, K. A. et al. 2014. Exposure and harm to combustion-derived particles: Searching for biomarkers. Presented at: European Aerosol Conference 2013, Prague, Czech Republic, 1-6 September 2013.
• Guschina, I., Everard, J. D., Kinney, A. J., Quant, P. A. and Harwood, J. 2014. Studies on the regulation of lipid biosynthesis in plants: application of control analysis to soybean. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(6), pp. 1488-1500. (10.1016/j.bbamem.2014.02.008)
• Koussoroplis, A., Nussbaumer, J., Arts, M. T., Guschina, I. and Kainz, M. J. 2014. Famine and feast in a common freshwater calanoid: effects of diet and temperature on fatty acid dynamics of Eudiaptomus gracilis. Limnology and Oceanography 59(3), pp. 947-958. (10.4319/lo.2014.59.3.0947)
• Ramli, U. S., Tang, M., Quant, P. A., Guschina, I., Fawcett, T. and Harwood, J. L. 2014. Informed metabolic engineering of oil crops using control analysis. Biocatalysis and Agricultural Biotechnology 3(1), pp. 49-52. (10.1016/j.bcab.2013.12.001)
• Steiner, T. et al. 2014. Protective role for properdin in progression of experimental murine atherosclerosis. PLoS ONE 9(3), article number: e92404. (10.1371/journal.pone.0092404)

2013

• Harwood, J. L., Ramli, U. S., Tang, M., Quant, P. A., Weselake, R. J., Fawcett, T. and Guschina, I. 2013. Regulation and enhancement of lipid accumulation in oil crops: The use of metabolic control analysis for informed genetic manipulation. European Journal of Lipid Science and Technology 115(11), pp. 1239-1246. (10.1002/ejlt.201300257)
• Randall, J., Cable, J., Guschina, I., Harwood, J. L. and Lello, J. 2013. Endemic infection reduces transmission potential of an epidemic parasite during co-infection. Proceedings of the Royal Society B: Biological Sciences 280(1769), article number: 20131500. (10.1098/rspb.2013.1500)
• Harwood, J. L. and Guschina, I. 2013. Regulation of lipid synthesis in oil crops. FEBS Letters 587(13), pp. 2079-2081. (10.1016/j.febslet.2013.05.018)
• Millership, S. et al. 2013. Correction for Millership et al., Increased lipolysis and altered lipid homeostasis protect  -synuclein-null mutant mice from diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 110(13), pp. 5269. (10.1073/pnas.1302920110)

2012

• Millership, S. et al. 2012. Increased lipolysis and altered lipid homeostasis protect γ-synuclein–null mutant mice from diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 109(51), pp. 20943-20948. (10.1073/pnas.1210022110)
• Wells, T. et al. 2012. Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome. Human Molecular Genetics 21(22), pp. 4836-4844. (10.1093/hmg/dds315)
• Tang, M., Guschina, I., O'Hara, P., Slabas, A. R., Quant, P. A., Fawcett, T. and Harwood, J. L. 2012. Metabolic control analysis of developing oilseed rape (Brassica napus cv Westar) embryos shows that lipid assembly exerts significant control over oil accumulation. New Phytologist 196(2), pp. 414-426. (10.1111/j.1469-8137.2012.04262.x)
• Elphick, L. M. et al. 2012. Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease Models & Mechanisms 5(2), pp. 231-240. (10.1242/dmm.008391)
• Falinska, A. M., Bascoul-Colombo, C., Guschina, I., Good, M. A. and Harwood, J. L. 2012. The role of n-3 dietary polyunsaturated fatty acids in brain function and ameliorating Alzheimer's disease: Opportunities for biotechnology in the development of nutraceuticals. Biocatalysis and Agricultural Biotechnology 1(2), pp. 159-166. (10.1016/j.bcab.2011.09.001)

2011

• McLaren, J. E., Michael, D. R., Guschina, I., Harwood, J. L. and Ramji, D. P. 2011. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46(11), pp. 1053-1061.
• Fuschino, J., Guschina, I., Dobson, G., Yan, N., Harwood, J. L. and Arts, M. 2011. Rising water temperatures alter lipid dynamics and reduce n-3 essential fatty acid concerntrations in Scenedesmus obliquus (chlorophyta). Journal of Phycology 47(4), pp. 763-774. (10.1111/j.1529-8817.2011.01024.x)
• Guschina, I., Millership, S., O'Donnell, V. B., Ninkina, N., Harwood, J. and Buchman, V. L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46(2), pp. 121-130. (10.1007/s11745-010-3486-0)
• Lewis, R. D., Perry, M. J., Guschina, I., Jackson, C. L., Morgan, B. P. and Hughes, T. R. 2011. CD55 deficiency protects against atherosclerosis in ApoE-deficient mice via C3a modulation of lipid metabolism. American Journal of Pathology 179(4), pp. 1601-1607. (10.1016/j.ajpath.2011.06.015)

2010

• Yang, X., Guschina, I., Hurst, S., Wood, S., Langford, M., Hawkes, T. and Harwood, J. 2010. The action of herbicides on fatty acid biosynthesis and elongation in barley and cucumber. Pest management Science 66(7), pp. 794-800. (10.1002/ps.1944)

2009

• Davies, J. S. et al. 2009. Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Molecular Endocrinology 23(6), pp. 914-924. (10.1210/me.2008-0432)
• Harwood, J. L. and Guschina, I. 2009. The versatility of algae and their lipid metabolism. Biochimie 91(6), pp. 679-684. (10.1016/j.biochi.2008.11.004)
• Guschina, I., Harris, K. M., Maskrey, B., Goldberg, B., Lloyd, D. and Harwood, J. 2009. The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. Journal of Eukaryotic Microbiology 56(1), pp. 52-57. (10.1111/j.1550-7408.2008.00365.x)

2008

• Hernandez, M. L., Guschina, I., Martinez-Rivas, J. M., Mancha, M. and Harwood, J. L. 2008. The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. Journal of Experimental Botany 59(9), pp. 2425-2435. (10.1093/jxb/ern121)

2007

• Markman, S., Guschina, I., Barnsley, S., Buchanan, K. L., Pascoe, D. and Muller, C. T. 2007. Endocrine disrupting chemicals accumulate in earthworms exposed to sewage effluent. Chemosphere 70(1), pp. 119-125. (10.1016/j.chemosphere.2007.06.045)

2006

• Sayanova, O., Haslam, R., Guschina, I., Lloyd, D., Christie, W. W., Harwood, J. L. and Napier, J. A. 2006. A bifunctional Δ12,Δ15-Desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n-1 series unsaturated fatty acids. Journal of Biological Chemistry 281(48), pp. 36533-36541. (10.1074/jbc.M605158200)