![Meike Heurich-Sevcenco](https://profiles-cardiff.imgix.net/attachments/2919?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Meike Heurich-Sevcenco
Senior Lecturer
- Available for postgraduate supervision
Overview
I am a Senior Lecturer at the School of Pharmacy and Pharmaceutical Sciences after joining the School in January 2017.
A Biochemist by training (Germany, 2003), I specialised in Analytical Biochemistry as part of my master thesis, and I gained my PhD (UK, 2008) in Applied Biochemistry & Biophysics and Biosensor development.
When I moved to Cardiff as a post-doctoral researcher in 2008, I joined the Complement Biology group ed by Prof C. Harris and Prof P. Morgan at the School of Medicine, Cardiff University.
In 2012, I was awarded an independent career development research fellowship (NISCHR, now Health and Care Research Wales) investigating the cross-talk mechanisms of complement with the coagulation system, working with Prof P. Collins at the School of Medicine, Cardiff. There, I established an independent research group in the field of Complement and Coagulation research.
In 2017, I was appointed Lecturer at the School of Pharmacy and Pharmaceutical Sciences, where I lead a group that focuses on the discovery and functional characterization of molecular crosstalk of blood proteins: primarily of the innate immune complement with the coagulation pathways. I also investigate the pathophysiology of these pathways in disease, with a particular focus of the role of complement and coagulation in the development of psychosis and schizophrenia.
We are interested in discovering novel blood biomarkers that may predict the development of psychosis, and identifying potential therapeutic targets through the analysis of complement and coagulation components and their activation products in blood plasma in disease.
The lab also develops and undertakes screening assays for the characterisation of small molecule inhibitors of complement and coagulation serine proteases and protein-protein interactions.
Keywords: biochemistry; biosensor; blood; innate immune system, complement; coagulation; psychosis
Publication
2024
- Heurich, M., Föcking, M. and Cotter, D. 2024. Complement C4, C4A and C4a – what they do and how they differ. Brain, Behavior, & Immunity - Health 39, article number: 100809. (10.1016/j.bbih.2024.100809)
- Byrne, J. F. et al. 2024. Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies. Brain, Behavior, and Immunity 119, pp. 188-196. (10.1016/j.bbi.2024.03.049)
- Kodosaki, E. et al. 2024. Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, C3d, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis. Biomarkers in Neuropsychiatry 10, article number: 100097. (10.1016/j.bionps.2024.100097)
- Byrne, J. F. et al. 2024. Proteomic biomarkers for the prediction of transition to psychosis in individuals at clinical high risk: A multi-cohort model development study. Schizophrenia Bulletin 50(3), pp. 579-588. (10.1093/schbul/sbad184)
- Healy, C. et al. 2024. Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms. Brain, Behavior, and Immunity 117, pp. 175-180. (10.1016/j.bbi.2023.12.018)
2023
- Heurich, M. and McCluskey, G. 2023. Complement and coagulation crosstalk - Factor H in the spotlight. Immunobiology 228(6), article number: 152707. (10.1016/j.imbio.2023.152707)
- Cropley, V., Kittel, M., Heurich-Sevcenco, M., Föcking, M., Leweke, F. and Pantelis, C. 2023. Complement proteins are elevated in blood serum but not CSF in clinical high-risk and antipsychotic-naïve first-episode psychosis. Brain, Behavior, and Immunity 113, pp. 136-144. (10.1016/j.bbi.2023.07.004)
- Susai, S. R. et al. 2023. Association of complement and coagulation pathway proteins with treatment response in first-episode psychosis: a longitudinal analysis of the OPTiMiSE clinical trial. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders 49(4), pp. 893-902. (10.1093/schbul/sbac201)
2022
- Susai, S. R. et al. 2022. Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis. Translational Psychiatry 12, article number: 454. (10.1038/s41398-022-02217-0)
- Heurich, M., Föcking, M., Mongan, D., Cagney, G. and Cotter, D. R. 2022. Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis. Molecular Psychiatry 27, pp. 127-140. (10.1038/s41380-021-01197-9)
2021
- Baker, A. T. et al. 2021. ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome. Science Advances 7(49), article number: eabl8213. (10.1126/sciadv.abl8213)
- Pathare, N., Szakmany, T., Hall, J. E. and Heurich, M. 2021. Plasma IgM levels differentiate between survivors and non-survivors of culture-positive and culture-negative sepsis and SIRS: a pilot study. Journal of Clinical Medicine 10(22), article number: 5391. (10.3390/jcm10225391)
- Howes, O., Cummings, C. and Heurich, M. 2021. Translation from genes to mechanism in schizophrenia: are immune-synaptic interactions the missing link?. Biological Psychiatry 90(9), pp. 593-595. (10.1016/j.biopsych.2021.08.014)
- Flude, B. M. et al. 2021. Targeting the complement serine protease MASP-2 as a therapeutic strategy for coronavirus infections. Viruses 13(2), article number: 312. (10.3390/v13020312)
- Mongan, D. et al. 2021. Development of proteomic prediction models for transition to psychotic disorder in the clinical high-risk state and psychotic experiences in adolescence. JAMA Psychiatry 78(1), pp. 77-90. (10.1001/jamapsychiatry.2020.2459)
2019
- Madrid-Gambin, F. et al. 2019. Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children. Biological Psychiatry 86(1), pp. 25-34. (10.1016/j.biopsych.2019.01.018)
- Föcking, M. et al. 2019. Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress. Molecular Psychiatry 26, pp. 524-533. (10.1038/s41380-018-0306-z)
2016
- Heurich-Sevcenco, M., Preston, R., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017)
2015
- Martínez-Barricarte, R. et al. 2015. The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome. Molecular Immunology 66(2), pp. 263-273. (10.1016/j.molimm.2015.03.248)
- Szakmany, T. and Heurich-Sevcenco, M. 2015. Immunomodulation in sepsis - why blunting the response doesn't work?. Journal of Infection 71(2), pp. 147-149. (10.1016/j.jinf.2015.04.019)
2014
- Ruseva, M. and Heurich-Sevcenco, M. 2014. Purification and characterization of human and mouse complement C3. In: Gadjeva, M. ed. The Complement System: Methods and Protocols., Vol. 1100. Methods in Molecular Biology Humana Press, pp. 75-91., (10.1007/978-1-62703-724-2_6)
2013
- Heurich, M., Altintas, Z. and Tothill, I. 2013. Computational Design of Peptide Ligands for Ochratoxin A. Toxins 5(6), pp. 1202-1218. (10.3390/toxins5061202)
2012
- Harris, C. L., Heurich, M., Rodriguez de Cordoba, S. and Morgan, B. P. 2012. The complotype: dictating risk for inflammation and infection. Trends in Immunology 33(10), pp. 513-521. (10.1016/j.it.2012.06.001)
2011
- Heurich, M., Martinez-Barricarte, R., Francis, N., Roberts, D. L., Rodriguez de Cordoba, S., Morgan, B. P. and Harris, C. L. 2011. Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proceedings of the National Academy of Sciences of the United States of America 108(21), pp. 8761-8766. (10.1073/pnas.1019338108)
2010
- Martínez-Barricarte, R. et al. 2010. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. Journal of Clinical Investigation 120(10), pp. 3702-3712. (10.1172/JCI43343)
Adrannau llyfrau
- Ruseva, M. and Heurich-Sevcenco, M. 2014. Purification and characterization of human and mouse complement C3. In: Gadjeva, M. ed. The Complement System: Methods and Protocols., Vol. 1100. Methods in Molecular Biology Humana Press, pp. 75-91., (10.1007/978-1-62703-724-2_6)
Erthyglau
- Heurich, M., Föcking, M. and Cotter, D. 2024. Complement C4, C4A and C4a – what they do and how they differ. Brain, Behavior, & Immunity - Health 39, article number: 100809. (10.1016/j.bbih.2024.100809)
- Byrne, J. F. et al. 2024. Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies. Brain, Behavior, and Immunity 119, pp. 188-196. (10.1016/j.bbi.2024.03.049)
- Kodosaki, E. et al. 2024. Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, C3d, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis. Biomarkers in Neuropsychiatry 10, article number: 100097. (10.1016/j.bionps.2024.100097)
- Byrne, J. F. et al. 2024. Proteomic biomarkers for the prediction of transition to psychosis in individuals at clinical high risk: A multi-cohort model development study. Schizophrenia Bulletin 50(3), pp. 579-588. (10.1093/schbul/sbad184)
- Healy, C. et al. 2024. Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms. Brain, Behavior, and Immunity 117, pp. 175-180. (10.1016/j.bbi.2023.12.018)
- Heurich, M. and McCluskey, G. 2023. Complement and coagulation crosstalk - Factor H in the spotlight. Immunobiology 228(6), article number: 152707. (10.1016/j.imbio.2023.152707)
- Cropley, V., Kittel, M., Heurich-Sevcenco, M., Föcking, M., Leweke, F. and Pantelis, C. 2023. Complement proteins are elevated in blood serum but not CSF in clinical high-risk and antipsychotic-naïve first-episode psychosis. Brain, Behavior, and Immunity 113, pp. 136-144. (10.1016/j.bbi.2023.07.004)
- Susai, S. R. et al. 2023. Association of complement and coagulation pathway proteins with treatment response in first-episode psychosis: a longitudinal analysis of the OPTiMiSE clinical trial. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders 49(4), pp. 893-902. (10.1093/schbul/sbac201)
- Susai, S. R. et al. 2022. Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis. Translational Psychiatry 12, article number: 454. (10.1038/s41398-022-02217-0)
- Heurich, M., Föcking, M., Mongan, D., Cagney, G. and Cotter, D. R. 2022. Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis. Molecular Psychiatry 27, pp. 127-140. (10.1038/s41380-021-01197-9)
- Baker, A. T. et al. 2021. ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome. Science Advances 7(49), article number: eabl8213. (10.1126/sciadv.abl8213)
- Pathare, N., Szakmany, T., Hall, J. E. and Heurich, M. 2021. Plasma IgM levels differentiate between survivors and non-survivors of culture-positive and culture-negative sepsis and SIRS: a pilot study. Journal of Clinical Medicine 10(22), article number: 5391. (10.3390/jcm10225391)
- Howes, O., Cummings, C. and Heurich, M. 2021. Translation from genes to mechanism in schizophrenia: are immune-synaptic interactions the missing link?. Biological Psychiatry 90(9), pp. 593-595. (10.1016/j.biopsych.2021.08.014)
- Flude, B. M. et al. 2021. Targeting the complement serine protease MASP-2 as a therapeutic strategy for coronavirus infections. Viruses 13(2), article number: 312. (10.3390/v13020312)
- Mongan, D. et al. 2021. Development of proteomic prediction models for transition to psychotic disorder in the clinical high-risk state and psychotic experiences in adolescence. JAMA Psychiatry 78(1), pp. 77-90. (10.1001/jamapsychiatry.2020.2459)
- Madrid-Gambin, F. et al. 2019. Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children. Biological Psychiatry 86(1), pp. 25-34. (10.1016/j.biopsych.2019.01.018)
- Föcking, M. et al. 2019. Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress. Molecular Psychiatry 26, pp. 524-533. (10.1038/s41380-018-0306-z)
- Heurich-Sevcenco, M., Preston, R., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017)
- Martínez-Barricarte, R. et al. 2015. The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome. Molecular Immunology 66(2), pp. 263-273. (10.1016/j.molimm.2015.03.248)
- Szakmany, T. and Heurich-Sevcenco, M. 2015. Immunomodulation in sepsis - why blunting the response doesn't work?. Journal of Infection 71(2), pp. 147-149. (10.1016/j.jinf.2015.04.019)
- Heurich, M., Altintas, Z. and Tothill, I. 2013. Computational Design of Peptide Ligands for Ochratoxin A. Toxins 5(6), pp. 1202-1218. (10.3390/toxins5061202)
- Harris, C. L., Heurich, M., Rodriguez de Cordoba, S. and Morgan, B. P. 2012. The complotype: dictating risk for inflammation and infection. Trends in Immunology 33(10), pp. 513-521. (10.1016/j.it.2012.06.001)
- Heurich, M., Martinez-Barricarte, R., Francis, N., Roberts, D. L., Rodriguez de Cordoba, S., Morgan, B. P. and Harris, C. L. 2011. Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proceedings of the National Academy of Sciences of the United States of America 108(21), pp. 8761-8766. (10.1073/pnas.1019338108)
- Martínez-Barricarte, R. et al. 2010. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. Journal of Clinical Investigation 120(10), pp. 3702-3712. (10.1172/JCI43343)
- Heurich-Sevcenco, M., Preston, R., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017)
- Martínez-Barricarte, R. et al. 2015. The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome. Molecular Immunology 66(2), pp. 263-273. (10.1016/j.molimm.2015.03.248)
Research
Research areas
- Mechanisms of complement and coagulation molecular crosstalk in health and disease
- Role of altered complement and coagulation pathways in psychosis
- Blood biomarkers
- Complement therapeutics
My past research has largely focussed on the characterisation of protein structure-function analysis leading to dysregulation of the complement system, part of the innate immune defence, including the complotype.
https://doi.org/10.1016%2Fj.molimm.2015.03.248
https://doi.org/10.1016%2Fj.it.2012.06.001
https://doi.org/10.1073%2Fpnas.1019338108
https://doi.org/10.1172%2Fjci43343
My research lab at the School of Pharmacy investigates the molecular crosstalk between the two innate defence systems against i) pathogen invasion and ii) bleeding, namely complement and coagulation. Both complement and coagulation systems are structurally and organisationally similar protein cascades that are activated by defined triggers, often in parallel.
Dysregulation of these systems have been associated with many diseases with pro-inflammatory and pro-coagulant pathology.
We are currently studying complement and coagulation crosstalk on the protein and cellular level in vitro and investigating in vivo mechanisms.
Current projects include:
i) With clinical colleagues at the School of Medicine and UHW Cardiff we are analysing the impact of complement factor H on coagulation function building on past work characterising the crosstalk of coagulation regulator thrombomodulin with complement regulator factor H.
https://doi.org/10.1016%2Fj.thromres.2016.07.017
Our most recent work describing "Complement Regulator Factor H is a Cofactor for Thrombin in both Pro- and Anticoagulant Roles" can be viewed as full-text preprint: https://www.biorxiv.org/content/10.1101/2021.07.22.452893v1
ii) In collaboration with colleagues at RCSI Dublin and RSCI Dublin my lab is studying the impact of complement and coagulation activation in individuals who progress to psychotic experiences or psychotic disorders.
https://doi.org/10.1038/s41380-018-0306-z
https://doi.org/10.1016/j.biopsych.2019.01.018
https://doi:10.1001/jamapsychiatry.2020.245
My most recent review article "Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis" describing the integral roles of these blood-borne pathways in the development of psychosis. Access the review article here: https://www.nature.com/articles/s41380-021-01197-9
Postdoc opportunities
Dr Heurich was awarded Wellcome Trust funding for a postdoctoral position in her lab commencing in 2021.
Schizophrenia is among the most expensive disorders in terms of quality of life and societal cost and there is an urgent need to improve our understanding of the interplay between genetic and environmental factors is important in the disease. We are investigating the plasma protein biomarkers of psychosis using mass spectrometry-based and biochemistry methods. We are using internationally unique samples, which we will use for discovery and validation studies. The successful candidate will work in close collaboration with Dr Gerard Cagney's proteomics lab at University College Dublin and Prof David Cotter’s lab at RSCI Dublin (see above for collaboration and publications, ii)
We are currently seeking a postdoctoral research associate to join the project team led by Dr Meike Heurich at the Cardiff School of Pharmacy and Pharmaceutical Sciences studying functional blood plasma biomarkers to analyse the risk of transition from clinical high risk to psychotic disorder. This research project is funded by the Wellcome Trust Innovations Flagship Programme.
Starting date in Spring/Summer 2021 (job opening/advert TBA).
Please email heurichm@cardiff.ac.uk for further inquiries.
THIS POSITION HAS NOW BEEN FILLED.
PhD opportunities
(SELF-FUNDED ONLY)
Dr Heurich is offering several PhD student opportunities starting October 2023. Note, self-funded only.
Please email heurichm@cardiff.ac.uk for further inquiries.
What's going on in the Heurich lab:
Here is the link to the ISTH 2020 congress (https://www.isth2020.org/), where our abstract was selected for oral presentation, which was delivered by PhD student Genevieve McCluskey.
here is the link to the ISTH highlights interview:
Here is the link to the Complement UK meeting 2021, where our abstract was selected for both oral and poster presentation. PhD student Genevieve McCluskey presented and won the oral presentation price. Congratulations!
https://complement.org.uk/conference/
Upcoming events
Complement UK, April 2023
The lab will be attending the Complement Diagnostics and Therapeutics – 7th Complement UK Symposium and Training Course. Meike is leading a tutorial about complement in disease. https://complement.org.uk/conference/
------------------------------------------------------------------------------------------------------------------------------------
Events and NEWS
2022
November
The lab attending the annual Cardiff Infection & Immunity meeting. https://www.iandiannualmeeting.co.uk/ Dr E Kodosaki is presenting a poster showcasing her recent work in the IMPETUS study funded by the Wellcome Trust: " Dysregulation of the blood-based immune complement pathways: emerging mechanisms in the development of psychosis".
September
We attended the NOVEL MECHANISMS, TOOLS, AND THERAPIES IN NEURO INFLAMMATION meeting at at King’s College London and presented a poster about early results from the IMPETUS study funded by the Wellcome Trust.
2021
July
Pleased to provide a preview of our most recent exciting research "Complement Regulator Factor H is a Cofactor for Thrombin in both Pro- and Anticoagulant Roles" as full-text preprint: https://www.biorxiv.org/content/10.1101/2021.07.22.452893v1
Pleased to publish our review "Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis" describing the integral roles of these blood-borne pathways in the development of psychosis. Access the review article here: https://www.nature.com/articles/s41380-021-01197-9
Related NEWS can be viewed here:
https://www.sciencedaily.com/releases/2021/07/210716112446.htm
https://www.psychiatrictimes.com/view/blood-clotting-immune-system-psychosis
https://neurosciencenews.com/blood-immune-clotting-psychosis-18932/
April
Dr Meike Heurich giving an oral presentation in Session 5 on 1st April 3021 at the virtual Hemostasis Science Weeks 2021.
SPR Symposium 2021, our virtual Biacore SPR Symposium on the 20th April 2020 from 13.30pm is bringing together scientists to share and enhance their knowledge of Biacore Surface Plasmon Resonance (SPR) technology for the analysis of a range of biomolecular interactions.
For registration and details:
https://www.cardiff.ac.uk/events/view/2501591-biacore-spr-symposium-2021
organised by Central Biotechnology Services Cardiff and Dr Meike Heurich.
--------------------------------
We hope that you found the virtual SPR symposium on the 20th of April interesting - and are now inspired to start thinking about how you can use SPR-Biacore technology for your work!
CBS Cardiff is hosting another free, virtual event focussing on SPR/Biacore application and training presented by Biacore specialist John Sinfield:
'Biacore SPR Symposium Application Training Day by Cytiva (hosted by CBS)' on Tuesday 11th May.
Here is the link to register:
Please feel free to contact me if you have any questions or comments.
------------------------------
Expert Reviews in Molecular Medicine - Call for papers
Teaching
Courses
- MPharm
- MSc Cancer Biology
- MSc Clinical Research
Lectures
Module lead PH1123 module: Structure and function of cells and microbes
- PH1123 module: Structure and function of cells - Cell Biology, unit lead
- PH1124 module: Human body systems - Basic Immunology, unit lead
- PH2113 module: Drugs and Diseases 1 - Clinical Immunology, unit lead
- PH3113 module: Drugs and Diseases 2 - Rheumatology
- PHT801 Cellular and Molecular Biology of Cancer - Immunology
- PHT801 Cellular and Molecular Biology of Cancer - Immunotherapy
- PHT804 MSc Cancer Biology - Research Methods
- PHT202 MSc Clinical Research - Immunology
Practical
- PH1124 module: Basic Anatomy
- PH1124 module: Pharmacology
Workshops
- PH1124: Immunology in disease
- PHT801: Immunotherapy in Cancer
- PHT804: Research Methodology, biophysics, surface plasmon resonance
Other
Non-modular teaching and teaching support, postgraduate research student supervision (PhD, MSc)
Biography
08/2022 - present - Senior Lecturer
Research in Protein Biochemistry and Experimental Therapeutics, College of Biomedical and Life Sciences, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK.
01/2017 – Lecturer (Teaching & Research)
Research in Protein Biochemistry and Experimental Therapeutics, College of Biomedical and Life Sciences, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK.
06/2016 -12/2016 Senior Postdoc in Molecular Virology, College of Biomedical and Life Sciences, School of Medicine, Institute of Infection & Immunity, Cardiff University, UK, “Developing human cytomegalovirus (CMV) for expansion of CD8+ T Cells with improved in vivo lifespan for immunotherapy”.
09/2013 – 08/2014 Lecturer secondment (Clinical Medicine, part-time alongside career development fellowship), School of Medicine, Cardiff University, UK
03/2012 – 06/2016 Career Development Research Fellowship in Blood Protein Biochemistry, Institute of Infection & Immunity, School of Medicine, Cardiff University, UK. “Cross-interaction of the innate immune response (complement system) with coagulation proteins in blood disorders”.
09/2011 – 02/2012 Postdoc/Research Associate in Complement Biology, Institute of Psychological Medicine & Clinical Neurosciences and Institute of Infection & Immunity, School of Medicine, Cardiff University, UK. “The role of complement receptor CR1 in Alzheimer’s disease”.
09/2008 – 08/2011 Postdoc/Research Associate in Complement Biology, Department of Infection, Immunity & Biochemistry, School of Medicine, Cardiff University, UK. “The role of complement dysregulation in disease” & “The Complotype: dictating risk for inflammation and infection”.
04/2007-07/2008 Research Assistant in Complement Biology, Department of Medical Biochemistry, School of Medicine, Cardiff University, UK.
Education
04/2004 – 04/2008 PhD in Biochemical and Biophysical Research, Cranfield Biotechnology Centre, Cranfield University, UK. “Development of a screen-printed, voltammetric electrochemical biosensor for the immunosuppressant mycotoxin ochratoxin A”.
03/2003 – 09/2003 Master thesis, Institute of Biomedicine and Chemistry, Kalmar University, Sweden. “Development of a diagnostic tool for markers of ischemic heart disease for early diagnosis of acute myocardial infarction”.
10/1997 – 09/2003 Diploma in Biochemistry, Germany
Honours and awards
02/2012 Career Development Research Fellowship Award, NISCHR (now Health and Care Research Wales)
12/2010 Young Scientist of the Year Award, British Society for Immunology
Professional memberships
2017 – present European Haematology Association
2012 – present International Society on Thrombosis and Haemostasis
2009 – present British Society for Immunology
2008 – present International Complement Society
2005 – present Biochemical Society, UK
Supervisions
Protein Biochemistry
Protein-protein interaction
Complement Biology
Blood proteins of the immune and coagulation systems
Blood proteins in the pathophysiology of disease
Contact Details
+44 29208 76657
Redwood Building, Room 2.57B, King Edward VII Avenue, Cardiff, CF10 3NB
