Dr Katja Hill

Articles

• Davies-Jones, J., Davies, P. R., Graf, A., Hewes, D., Hill, K. E. and Pascoe, M. 2024. Photoinduced force microscopy as a novel method for the study of microbial nanostructures. Nanoscale 16(1), pp. 223-236. (10.1039/D3NR03499B)
• Pritchard, M. F. et al. 2023. Structure–activity relationships of low molecular weight alginate oligosaccharide therapy against Pseudomonas aeruginosa. Biomolecules 13(9), article number: 1366. (10.3390/biom13091366)
• Xue, W. et al. 2023. Defining in vitro topical antimicrobial and antibiofilm activity of epoxy-tigliane structures against oral pathogens. Journal of Oral Microbiology 15(1), article number: 2241326. (10.1080/20002297.2023.2241326)
• Powell, L. C. et al. 2023. Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms. Frontiers in Cellular and Infection Microbiology 13, article number: 1122340. (10.3389/fcimb.2023.1122340)
• Powell, L. C. et al. 2022. Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine 14(662) (10.1126/scitranslmed.abn3758)
• Stokniene, J., Varache, M., Rye, P. D., Hill, K. E., Thomas, D. W. and Ferguson, E. L. 2022. Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment. Scientific Reports 12, article number: 4986. (10.1038/s41598-022-08927-1)
• Oakley, J. L. et al. 2021. Phenotypic and genotypic adaptations in Pseudomonas aeruginosa biofilms following long-term exposure to an alginate oligomer therapy. mSphere 6(1), pp. e01216-20. (10.1128/mSphere.01216-20)
• Powell, L. C. et al. 2021. Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. npj Biofilms and Microbiomes 7, article number: 13. (10.1038/s41522-020-00172-6)
• Incledion, A. et al. 2021. A new look at the purported health benefits of commercial and natural clays. Biomolecules 11(1), article number: 58. (10.3390/biom11010058)
• Stokniene, J. et al. 2020. Bi-functional alginate oligosaccharide–polymyxin conjugates for improved treatment of multidrug-resistant gram-negative bacterial infections. Pharmaceutics 12(11), article number: 1080. (10.3390/pharmaceutics12111080)
• Jack, A. A. et al. 2019. Cellulose nanofibril formulations incorporating a low molecular weight alginate oligosaccharide modify bacterial biofilm development. Biomacromolecules 20(8), pp. 2953-2961. (10.1021/acs.biomac.9b00522)
• Pritchard, M. F. et al. 2019. Mucin structural interactions with an alginate oligomer mucolytic in cystic fibrosis sputum. Vibrational Spectroscopy 103, article number: 102932. (10.1016/j.vibspec.2019.102932)
• Powell, L. C. et al. 2018. Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes 4, article number: 13. (10.1038/s41522-018-0056-3)
• Jack, A. A. et al. 2018. Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum Sensing Systems in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 62(5), article number: e02318-17. (10.1128/AAC.02318-17)
• Pritchard, M., Jack, A., Powell, L., Sadh, H., Hill, K. E., Thomas, D. W. and Rye, P. D. 2017. Alginate Oligosaccharides modify hyphal infiltration of Candida albicans in an in vitro model of invasive Human Candidosis. Journal of Applied Microbiology 123(3), pp. 625-636. (10.1111/jam.13516)
• Pritchard, M. F. et al. 2017. A low-molecular-weight alginate oligosaccharide disrupts pseudomonal microcolony formation and enhances antibiotic effectiveness. Antimicrobial Agents and Chemotherapy 61(9), article number: e00762-17. (10.1128/AAC.00762-17)
• Pritchard, M. F. et al. 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports 7, article number: 44731. (10.1038/srep44731)
• Jack, A. A. et al. 2017. The interaction of wood nanocellulose dressings and the wound pathogen P. aeruginosa. Carbohydrate Polymers 157, pp. 1955-1962. (10.1016/j.carbpol.2016.11.080)
• Pritchard, M. F. et al. 2016. A new class of safe oligosaccharide polymer therapy to modify the mucus barrier of chronic respiratory disease. Molecular Pharmaceutics 13(3), pp. 863-872. (10.1021/acs.molpharmaceut.5b00794)
• Powell, L. C., Khan, S., Chinga-Carrasco, G., Wright, C. J., Hill, K. E. and Thomas, D. W. 2016. An investigation of Pseudomonas aeruginosa biofilm growth on novel nanocellulose fiber dressings. Carbohydrate Polymers 137, pp. 191-197. (10.1016/j.carbpol.2015.10.024)
• Rees, A., Powell, L. C., Chinga-Carrasco, G., Gethin, D. T., Syverud, K., Hill, K. E. and Thomas, D. W. 2015. 3D bioprinting of carboxymethylated-periodate oxidized nanocellulose constructs for wound dressing applications. BioMedical Research International 2015, pp. 1-7., article number: 925757. (10.1155/2015/925757)
• Tondervik, A. et al. 2014. Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of anti-fungals against Candida and Aspergillus spp. PLoS ONE, article number: e112518. (10.1371/journal.pone.0112518)
• Powell, L. C. et al. 2014. A nanoscale characterization of the interaction of a novel alginate oligomer with the cell surface and motility of pseudomonas aeruginosa. American Journal of Respiratory Cell and Molecular Biology 50(3), pp. 483-492. (10.1165/rcmb.2013-0287OC)
• McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
• Gethin, D. T. et al. 2014. Studies on the 3D printing of nanocellulose structures. Advances in Printing and Media Technology XLI(1 A2), pp. 91-95.
• Roberts, J. L. et al. 2013. An in vitro study of alginate oligomer therapies on oral biofilms. Journal of Dentistry 41(10), pp. 892-899. (10.1016/j.jdent.2013.07.011)
• Powell, L. C. et al. 2013. The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling 29(4), pp. 413-421. (10.1080/08927014.2013.777954)
• Hooper, S. J., Percival, S. L., Hill, K. E., Thomas, D. W., Hayes, A. J. and Williams, D. W. 2012. The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal 9(6), pp. 633-642. (10.1111/j.1742-481X.2012.00927.x)
• Khan, S. et al. 2012. Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics. Antimicrobial Agents and Chemotherapy 56(10), pp. 5134-5141. (10.1128/AAC.00525-12)
• Percival, S. L., Hill, K. E., Williams, D. W., Hooper, S. J., Thomas, D. W. and Costerton, J. W. 2012. A review of the scientific evidence for biofilms in wounds. Wound Repair and Regeneration 20(5), pp. 647-657. (10.1111/j.1524-475X.2012.00836.x)
• Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
• Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
• Hooper, S. J., Williams, D. W., Thomas, D. W., Hill, K. E. and Percival, S. L. 2012. An in vitro comparison of two silver- containing antimicrobial wound dressings. Ostomy Wound Management 58(1), pp. 16-22.
• Percival, S. L., Hill, K. E., Malic, S., Thomas, D. W. and Williams, D. W. 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19(1), pp. 1-9. (10.1111/j.1524-475X.2010.00651.x)
• Malic, S., Hill, K. E., Playle, R. A., Thomas, D. W. and Williams, D. W. 2011. In vitro interaction of chronic wound bacteria in biofilms. Journal of Wound Care 20(12), pp. 569-577.
• Hill, K. E., Malic, S., McKee, R., Rennison, T., Harding, K. G., Williams, D. W. and Thomas, D. W. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65(6), pp. 1195-1206. (10.1093/jac/dkq105)
• Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)
• Malic, S., Hill, K. E., Ralphs, J. R., Hayes, A. J., Thomas, D. W., Potts, A. J. C. and Williams, D. W. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22(3), pp. 188-194. (10.1111/j.1399-302X.2007.00344.x)
• Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
• Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
• Howell-Jones, R. S., Wilson, M., Hill, K. E., Howard, A. J., Price, P. E. and Thomas, D. W. 2005. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. Journal of Antimicrobial Chemotherapy 55(2), pp. 143-149. (10.1093/jac/dkh513)
• Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
• Hill, K. E. and Weightman, A. J. 2003. Horizontal transfer of dehalogenase genes on IncP1[beta] plasmids during bacterial adaptation to degrade [alpha]-halocarboxylic acids. FEMS Microbiology Ecology 45(3), pp. 273-282. (10.1016/S0168-6496(03)00158-2)
• Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
• Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
• Weightman, A. J., Topping, A. W., Hill, K. E., Lee, L. L., Sakai, K., Slater, J. H. and Thomas, A. W. 2002. Transposition of DEH, a broad-host-range transposon flanked by ISPpu12, in Pseudomonas putida is associated with genomic rearrangements and dehalogenase gene silencing. Journal of Bacteriology 184(23), pp. 6581-6591. (10.1128/JB.184.23.6581-6591.2002)
• Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
• Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
• Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
• Hill, K. E., Marchesi, J. R. and Weightman, A. J. 1999. Investigation of two evolutionarily unrelated halocarboxylic acid dehalogenase gene families. Journal of Bacteriology 181(9), pp. 2535-2547. (10.1128/JB.181.8.2535-2547.1999)
• Hill, K. E. and Top, E. M. 1998. Gene transfer in soil systems using microcosms. FEMS Microbiology Ecology 25(4), pp. 319-329. (10.1111/j.1574-6941.1998.tb00483.x)
• Ashelford, K. E. et al. 1997. Using microcosms to study gene transfer in aquatic habitats. FEMS Microbiology Ecology 23(2), pp. 81-94. (10.1111/j.1574-6941.1997.tb00393.x)
• Hill, K. E., Fry, J. C., Weightman, A. J., Day, M. J., Bradley, D. J. and Cousland, B. 1995. Retrotransfer of IncP1-like plasmids from aquatic bacteria. Letters in Applied Microbiology 20(5), pp. 317-322. (10.1111/j.1472-765X.1995.tb00454.x)
• Hill, K. E., Fry, J. C. and Weightman, A. J. 1994. Gene transfer in the aquatic environment: persistence and mobilization of the catabolic recombinant plasmid pD10 in the epilithon. Microbiology 140(7), pp. 1555-1563. (10.1099/13500872-140-7-1555)
• Hill, K. E., Weightman, A. J. and Fry, J. C. 1992. Isolation and screening of plasmids from the epilithon which mobilize recombinant plasmid pD10. Applied and Environmental Microbiology 58, pp. 1292-1300.
• Glenister, D. A., Salamon, K. E., Smith, K., Beighton, D. and Keevil, C. W. 1988. Enhanced growth of complex communities of dental plaque bacteria in mucin-limited continuous culture. Microbial Ecology in Health and Disease 1(1), pp. 31-38. (10.3109/08910608809140176)

Book sections

• Hill, K. E., Marchesi, J. R. and Fry, J. C. 1996. Conjugation in the epilithon. In: Akkermans, A. D. L., Van Elsas, J. D. and de Bruijn, F. J. eds. Molecular Microbial Ecology Manual. Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 125-152., (10.1007/978-94-009-0215-2_9)

Conferences

• Sharma, P. et al. 2023. In vitro antibiofilm activity of hexylresorcinol lozenges against oropharyngeal pathogens. Presented at: 2023 ERS International Congress, Milan, Italy, 9-13 September 2023. European Respiratory Society, (10.1183/13993003.congress-2023.PA603)

• Khan, S. et al. 2012. Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics. Antimicrobial Agents and Chemotherapy 56(10), pp. 5134-5141. (10.1128/AAC.00525-12)
• Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
• Hill, K. E., Malic, S., McKee, R., Rennison, T., Harding, K. G., Williams, D. W. and Thomas, D. W. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65(6), pp. 1195-1206. (10.1093/jac/dkq105)
• Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)
• Howell-Jones, R. S., Wilson, M., Hill, K. E., Howard, A. J., Price, P. E. and Thomas, D. W. 2005. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. Journal of Antimicrobial Chemotherapy 55(2), pp. 143-149. (10.1093/jac/dkh513)
• Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)