Professor Peter Holmans

2024

• Tume, C. E., Chick, S. L., Holmans, P. A., Rees, E., O'Donovan, M. C., Cameron, D. and Bray, N. J. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4(5), article number: 100345. (10.1016/j.bpsgos.2024.100345)
• Legge, S. E. et al. 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 81, pp. 681-690. (10.1001/jamapsychiatry.2024.0200)
• Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)
• Uzochukwu, E. C. et al. 2024. Modelling disease progression of Multiple Sclerosis in a South Wales cohort. Neuroepidemiology 58(3), pp. 218-226. (10.1159/000536427)
• Hall, J. H. et al. 2024. Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs). Translational Psychiatry 14(1), article number: 259. (10.1038/s41398-024-02975-z)
• Kim, K. et al. 2024. Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington's disease. Proceedings of the National Academy of Sciences 121(16), article number: e2322924121. (10.1073/pnas.2322924121)
• Hess, J. L. et al. 2024. A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 195(2), article number: e32957. (10.1002/ajmg.b.32957)
• Kreft, K. L. et al. 2024. Relevance of multiple sclerosis severity genotype in predicting disease course: A real-world cohort. Annals of Neurology 95(3), pp. 459-470. (10.1002/ana.26831)
• Hong, E. P. et al. 2024. Modification of Huntington's disease by short tandem repeats. Brain Communications 6(2), article number: fcae016. (10.1093/braincomms/fcae016)
• Cardno, A. G. et al. 2024. Associations of psychotic symptom dimensions with clinical and developmental variables in twin and general clinical samples.. The British Journal of Psychiatry, pp. 1-8. (10.1192/bjp.2024.129)

2023

• Clifton, N., Schulmann, A., Schizophrenia Working Group of the Psychiatric Genomics Consorti, ., Holmans, P., O'Donovan, M. and Vawter, M. 2023. The relationship between case-control differential gene expression from brain tissue and genetic associations in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 192(5-6), pp. 85-92. (10.1002/ajmg.b.32931)
• Harrison, J. R. et al. 2023. Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults. Brain Communications 5(5), article number: fcad229. (10.1093/braincomms/fcad229)
• Le Guen, Y. et al. 2023. Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences 120(36), article number: e2302720120. (10.1073/pnas.2302720120)
• Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
• Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
• Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse, M., Godley, M. D. and Griffin, B. A. 2023. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology 23, pp. 115-148. (10.1007/s10742-022-00280-0)
• Rammos, A., Kirov, G., Hubbard, L., Walters, J., Holmans, P., Owen, M. and Rees, E. 2023. Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia. Molecular Psychiatry 28, pp. 2081-2087. (10.1038/s41380-023-02013-2)
• Dimitriadis, S. I. et al. 2023. Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk. Cerebral Cortex 33(6), pp. 2997-3011. (10.1093/cercor/bhac256)

2022

• Crawford, K. et al. 2022. Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing. Molecular Psychiatry (10.1038/s41380-022-01926-8)
• Mirza-Davies, A. et al. 2022. The impact of genetic risk for Alzheimer’s disease on the structural brain networks of young adults. Frontiers in Neuroscience 16, article number: 987677. (10.3389/fnins.2022.987677)
• Clifton, N. et al. 2022. Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics 31(18), pp. 3095-3106. (10.1093/hmg/ddac105)
• Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93(S1), article number: A44. (10.1136/jnnp-2022-ehdn.114)
• Lobanov, S. et al. 2022. Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1. npj Genomic Medicine 7, article number: 53. (10.1038/s41525-022-00317-w)
• Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79(10), pp. 963-970. (10.1001/jamapsychiatry.2022.2289)
• Croft, J. et al. 2022. A computational analysis of abnormal belief-updating processes and their association with psychotic experiences and childhood trauma in a UK birth cohort. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 7(7), pp. 725-734. (10.1016/j.bpsc.2021.12.007)
• Hou, J. et al. 2022. Polygenic resilience scores capture protective genetic effects for Alzheimer’s disease. Translational Psychiatry 12(1), article number: 296. (10.1038/s41398-022-02055-0)
• Crawford, K. et al. 2022. Analysis of Alzheimer's disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathways. [Online]. medRxiv: Cold Spring Harbor Laboratory. (10.1101/2022.06.29.22276952) Available at: https://doi.org/10.1101/2022.06.29.22276952
• Hwang, Y. et al. 2022. Both cis and trans-acting genetic factors drive somatic instability in female carriers of the FMR1 premutation. Scientific Reports 12, article number: 10419. (10.1038/s41598-022-14183-0)
• Lee, J. et al. 2022. Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. American Journal of Human Genetics 109(5), pp. 885-899. (10.1016/j.ajhg.2022.03.004)
• McAllister, B. et al. 2022. Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset. Nature Neuroscience 25, pp. 446-457. (10.1038/s41593-022-01033-5)
• Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
• Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
• Jones, H. J. et al. 2022. Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence. Psychological Medicine 52(1), pp. 132-139. (10.1017/S0033291720001798)
• Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)

2021

• Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. CoBWeb: a user-friendly web application to estimate causal treatment effects from observational data using multiple algorithms. [Online]. Cornell University. Available at: https://arxiv.org/abs/2112.05035
• Dimitriadis, S. I. et al. 2021. Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk. Translational Psychiatry 11, article number: 592. (10.1038/s41398-021-01678-z)
• Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47(5), pp. 1375-1384. (10.1093/schbul/sbab036)
• Clifton, N. E. et al. 2021. Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry 90(6) (10.1016/j.biopsych.2021.03.009)
• Rees, E. et al. 2021. Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations. Nature Communications 12, article number: 5353. (10.1038/s41467-021-25532-4)
• Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. Examining the effect of exercise on the progression and severity of Huntington's disease using different covariate balancing methods and simulated data derived from the PACE-HD study. Presented at: Huntington Study Group 2020: HD in Focus, 29-31 October 2020, Vol. 92. Vol. 1. BMJ Publishing Group, (10.1136/jnnp-2021-EHDN.74)
• Cleynen, I. et al. 2021. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Molecular Psychiatry, pp. 4496-4510. (10.1038/s41380-020-0654-3)
• Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
• Clifton, N. E. et al. 2021. Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry 26, pp. 2977-2990. (10.1038/s41380-020-00912-2)
• Jones, R. E., Andrews, R., Holmans, P., Hill, M. and Taylor, P. R. 2021. Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease. Scientific Reports 11(1), article number: 14935. (10.1038/s41598-021-94324-z)
• Hubbard, L. et al. 2021. Rare copy number variations are associated with poorer cognition in schizophrenia. Biological Psychiatry 90(1), pp. 28-34. (10.1016/j.biopsych.2020.11.025)
• Mullins, N. et al. 2021. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics 53, pp. 817-829. (10.1038/s41588-021-00857-4)
• de Rojas, I. et al. 2021. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications 12(1), article number: 3417. (10.1038/s41467-021-22491-8)
• Harwood, J., Leonenko, G., Sims, R., Escott-Price, V., Williams, J. and Holmans, P. 2021. Defining functional variants associated with Alzheimer's disease in the induced immune response. Brain Communications 3(2), article number: fcab083. (10.1093/braincomms/fcab083)
• Chen, Z. et al. 2021. Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage. Nature Communications 12(1), article number: 2076. (10.1038/s41467-021-22262-5)
• Hess, J. L. et al. 2021. A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry 26(3), pp. 800-815. (10.1038/s41380-019-0463-8)
• McAllister, B. et al. 2021. Timing and impact of psychiatric, cognitive, and motor abnormalities in Huntington disease. Neurology 96(19), pp. e2395-e2406. (10.1212/WNL.0000000000011893)
• Hong, E. P. et al. 2021. Huntington's disease pathogenesis: two sequential components. Journal of Huntington's Disease 10(1), pp. 35-51. (10.3233/JHD-200427)
• Donaldson, J., Powell, S., Rickards, N., Holmans, P. and Jones, L. 2021. What is the pathogenic CAG expansion length in Huntington’s disease?. Journal of Huntington's Disease 10(1), pp. 175-202. (10.3233/JHD-200445)
• Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. How balance and sample size impact bias in the estimation of causal treatment effects: a simulation study. [Online]. Cornell University. Available at: https://arxiv.org/abs/2107.09009
• Katzourou, I. et al. 2021. Cognitive decline in Alzheimer’s disease is not associated with APOE. Journal of Alzheimer's Disease 84(1), pp. 141-149. (10.3233/jad-210685)
• Hong, E. P. et al. 2021. Association analysis of chromosome X to identify genetic modifiers of Huntington's disease. Journal of Huntington's Disease 10(3), pp. 367-375. (10.3233/JHD-210485)

2020

• Holmans, P. 2020. Using genetics to increase specificity of outcome prediction in psychiatric disorders: prospects for progression. American Journal of Psychiatry 177(10), pp. 884-887. (10.1176/appi.ajp.2020.20081181)
• Akingbuwa, W. A. et al. 2020. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals. JAMA Psychiatry 77(7), pp. 715-728. (10.1001/jamapsychiatry.2020.0527)
• Kim, K. et al. 2020. Genetic and functional analyses point to FAN1 as the source of multiple Huntington Disease modifier effects. American Journal of Human Genetics 107(1), pp. 96-110. (10.1016/j.ajhg.2020.05.012)
• Ellis, N. et al. 2020. Genetic risk underlying psychiatric and cognitive symptoms in Huntington’s Disease. Biological Psychiatry 87(9), pp. 857-865. (10.1016/j.biopsych.2019.12.010)
• Flower, M., Lomeikaite, V., Holmans, P., Jones, L., Tabrizi, S. J. and Monckton, D. G. 2020. Reply: The repeat variant in MSH3 is not a genetic modifier for spinocerebellar ataxia type 3 and Friedreich’s ataxia. Brain 143(4), article number: e26. (10.1093/brain/awaa044)
• Szatkiewicz, J. P. et al. 2020. Characterization of single gene copy number variants in schizophrenia. Biological Psychiatry 87(8), pp. 736-744. (10.1016/j.biopsych.2019.09.023)
• Sullivan, S. A. et al. 2020. A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder. American Journal of Psychiatry 177(4), pp. 308-317. (10.1176/appi.ajp.2019.19060654)
• Richards, A. et al. 2020. The relationship between polygenic risk scores and cognition in schizophrenia. Schizophrenia Bulletin 46(2), pp. -. (10.1093/schbul/sbz061)
• Rees, E. et al. 2020. De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nature Neuroscience 23(2), pp. 179-184. (10.1038/s41593-019-0565-2)
• Hall, L. S. et al. 2020. A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia. Human Molecular Genetics 29(1), pp. 159-167. (10.1093/hmg/ddz253)
• McAllister, B. et al. 2020. The onset and prevalence of motor and psychiatric symptoms in Huntington’s disease. [Online]. bioRxiv. (10.1101/2020.05.26.116798)
• Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse-Morris, M. and Griffin, B. A. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online]. arXiv. Available at: https://arxiv.org/abs/2010.09563

2019

• Legge, S. E. et al. 2019. Association of genetic liability to psychotic experiences with neuropsychotic disorders and traits. JAMA Psychiatry 76(12), pp. 1256-1265. (10.1001/jamapsychiatry.2019.2508)
• Lam, M. et al. 2019. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics 51, pp. 1670-1678. (10.1038/s41588-019-0512-x)
• Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
• Ciosi, M. et al. 2019. A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes. EBioMedicine 48, pp. 568-580. (10.1016/j.ebiom.2019.09.020)
• Pain, O. et al. 2019. Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics. Biological Psychiatry 86(4), pp. 265-273. (10.1016/j.biopsych.2019.04.034)
• Lee, J. et al. 2019. CAG repeat not polyglutamine length determines timing of Huntington’s disease onset. Cell 178(4), pp. 887-099.e14. (10.1016/j.cell.2019.06.036)
• Baker, E. et al. 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14(7), article number: e0218111. (10.1371/journal.pone.0218111)
• Flower, M. et al. 2019. MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1. Brain 142(7), pp. 1876-1886. (10.1093/brain/awz115)
• Chawner, S. J. R. A. et al. 2019. Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study. Lancet Psychiatry 6(6), pp. 493 - 505. (10.1016/S2215-0366(19)30123-3)
• Stahl, E. A. et al. 2019. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics 51, pp. 793-803. (10.1038/s41588-019-0397-8)
• Gorman, K. M. et al. 2019. Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia. American Journal of Human Genetics 104(5), pp. 948-956. (10.1016/j.ajhg.2019.03.005)
• Rees, E. et al. 2019. Targeted sequencing of 10,198 samples confirms abnormalities in neuronal activity and implicates voltage-gated sodium channels in schizophrenia pathogenesis. Biological Psychiatry 85(7), pp. 554-562. (10.1016/j.biopsych.2018.08.022)
• Lancaster, T. M. et al. 2019. Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype-based approach. Schizophrenia Bulletin 45(2), pp. 405-414. (10.1093/schbul/sby037)
• Kunkle, B. W. et al. 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51(3), pp. 414-430. (10.1038/s41588-019-0358-2)
• Chawner, S., Owen, M. J., Holmans, P., Raymond, L., Skuse, D., Hall, J. and van den Bree, M. 2019. Genotype-phenotype relationships in children with copy number variants associated with high neuropsychiatric risk: Findings from the Intellectual Disability & Mental Health: Assessing the Genomic Impact on Neurodevelopment (IMAGINE-ID) study.. [Online]. BioRxiv. (10.1101/535708) Available at: https://doi.org/10.1101/535708
• Goold, R. et al. 2019. FAN1 modifies Huntington's disease progression by stabilising the expanded HTT CAG repeat. Human Molecular Genetics 28(4), pp. 650-661., article number: ddy375. (10.1093/hmg/ddy375)
• Clifton, N. E. et al. 2019. Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry 9, article number: 74. (10.1038/s41398-019-0405-x)
• Vivian-Griffiths, T. et al. 2019. Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(1), pp. 80-85. (10.1002/ajmg.b.32705)

2018

• Beltrami, C. et al. 2018. Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. American Journal of Pathology 188(9), pp. 1982-1992. (10.1016/j.ajpath.2018.06.006)
• Jones, H. J. et al. 2018. Investigating the genetic architecture of general and specific psychopathology in adolescence. Translational Psychiatry 8(1), article number: 145. (10.1038/s41398-018-0204-9)
• Ahmad, S. et al. 2018. Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study. Alzheimer's and Dementia 14(7), pp. 848-857. (10.1016/j.jalz.2018.01.005)
• McNulty, P. et al. 2018. Reduced cancer incidence in Huntington's disease: analysis in the Registry study. Journal of Huntington's Disease 7(3), pp. 209-222. (10.3233/JHD-170263)
• Baker, E., Schmidt, K. M., Sims, R., O'Donovan, M. C., Williams, J., Holmans, P. and Escott-Price, V. 2018. POLARIS: polygenic LD-adjusted risk score approach for set-based analysis of GWAS data. Genetic Epidemiology 42(4), pp. 366-377. (10.1002/gepi.22117)
• Anttila, V. et al. 2018. Analysis of shared heritability in common disorders of the brain. Science 360(6395), article number: eaap8757. (10.1126/science.aap8757)
• Martin, J. et al. 2018. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry 83(12), pp. 1044-1053. (10.1016/j.biopsych.2017.11.026)
• Ruderfer, D. M. et al. 2018. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173(7), pp. 1705-1715.e16. (10.1016/j.cell.2018.05.046)
• Holmans, P. and Stone, T. 2018. Using genomic data to find disease-modifying loci in Huntington's Disease (HD). In: Precious, S. V., Rosser, A. E. and Dunnett, S. eds. Huntington’s Disease., Vol. 1780. Methods in Molecular Biology Humana Press, pp. 443-461., (10.1007/978-1-4939-7825-0_20)
• Chao, M. J. et al. 2018. Population-specific genetic modification of Huntington's disease in Venezuela. PLoS Genetics 14(5), article number: e1007274. (10.1371/journal.pgen.1007274)
• Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50, pp. 381-389. (10.1038/s41588-018-0059-2)
• McColgan, P. et al. 2018. Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes. Biological Psychiatry 83(5), pp. 456-465. (10.1016/j.biopsych.2017.10.019)
• Allardyce, J. et al. 2018. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75(1), pp. 28-35. (10.1001/jamapsychiatry.2017.3485)

2017

• Leonenko, G. et al. 2017. Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(7), pp. 724-731. (10.1002/ajmg.b.32560)
• Legge, S. E. et al. 2017. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry 22, pp. 1502-1508. (10.1038/mp.2016.97)
• Holmans, P. A., Massey, T. H. and Jones, L. 2017. Genetic modifiers of Mendelian disease: Huntington's disease and the trinucleotide repeat disorders. Human Molecular Genetics 26(R2), pp. R83-R90. (10.1093/hmg/ddx261)
• Lee, J. et al. 2017. A modifier of Huntington's disease onset at the MLH1 locus. Human Molecular Genetics 26(19), pp. 3859-3867. (10.1093/hmg/ddx286)
• Sims, R. et al. 2017. Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics 49, pp. 1373-1384. (10.1038/ng.3916)
• Hensman Moss, D. J. et al. 2017. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurology 16(9), pp. 701-711. (10.1016/S1474-4422(17)30161-8)
• Chao, M. J. et al. 2017. Haplotype-based stratification of Huntington's disease. European Journal of Human Genetics 25, pp. 1202-1209. (10.1038/ejhg.2017.125)
• Phillips, T. J. et al. 2017. Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Scientific Reports 7, pp. -., article number: 9079. (10.1038/s41598-017-06300-1)
• Allardyce, J. et al. 2017. Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia. [Online]. bioRxiv. Available at: http://dx.doi.org/10.1101/160119
• Weiner, D. J. et al. 2017. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nature Genetics 49(7), pp. 978-985. (10.1038/ng.3863)
• Hendricks, A. E. et al. 2017. Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity. Scientific Reports 7, article number: 4394. (10.1038/s41598-017-03054-8)
• Witt, S. H. et al. 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression. Translational Psychiatry 7, article number: e1155.
• The Autism Spectrum Disorders Working Group of The Psychiatric G, ., Anney, R. J. L. and Holmans, P. 2017. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Molecular Autism 8, article number: 21. (10.1186/s13229-017-0137-9)
• Hensman Moss, D. J. et al. 2017. Huntington's disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer's disease. Scientific Reports 7, pp. -., article number: 44849. (10.1038/srep44849)
• McLaughlin, R. L. et al. 2017. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications 8, article number: 14774. (10.1038/ncomms14774)
• Bowles, K. R., Stone, T. C., Holmans, P. A., Allen, N. D., Dunnett, S. B. and Jones, L. 2017. SMAD transcription factors are altered in cell models of HD and regulate HTT expression. Cellular Signalling 31, pp. 1-14. (10.1016/j.cellsig.2016.12.005)
• Marshall, C. R. et al. 2017. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 49, pp. 27-35. (10.1038/ng.3725)

2016

• Rees, E. et al. 2016. Analysis of intellectual disability copy number variants for association with schizophrenia. JAMA Psychiatry 73(9), pp. 963-969. (10.1001/jamapsychiatry.2016.1831)
• Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
• Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
• Tansey, K. E. et al. 2016. Common alleles contribute to schizophrenia in CNV carriers. Molecular Psychiatry 21, pp. 1085-1089. (10.1038/mp.2015.143)
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2015

• Escott-Price, V. et al. 2015. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain 138(12), pp. 3673-3684. (10.1093/brain/awv268)
• Bayram-Weston, Z. et al. 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16, pp. -., article number: 1079. (10.1186/s12864-015-2251-4)
• Tansey, K. E. et al. 2015. Common alleles contribute to schizophrenia in CNV carriers [Erratum]. Molecular Psychiatry 21, article number: 1153. (10.1038/mp.2015.170)
• Kun-Rodrigues, C. et al. 2015. A systematic screening to identifyde novomutations causing sporadic early-onset Parkinson's disease. Human Molecular Genetics 24(23), pp. 6711-20. (10.1093/hmg/ddv376)
• Walter, K. et al. 2015. The UK10K project identifies rare variants in health and disease. Nature 526, pp. 82-90. (10.1038/nature14962)
• Lee, S. H. et al. 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44(5), pp. 1706-1721. (10.1093/ije/dyv136)
• Vilhjálmsson, B. et al. 2015. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97(4), pp. 576-592. (10.1016/j.ajhg.2015.09.001)
• Huang, J. et al. 2015. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nature Communications 6, article number: 8111. (10.1038/ncomms9111)
• Leonpacher, A. K. et al. 2015. Distinguishing bipolar from unipolar depression: the importance of clinical symptoms and illness features. Psychological Medicine 45(11), pp. 2437-2446. (10.1017/S0033291715000446)
• Lee, J. M. et al. 2015. Identification of genetic factors that modify clinical onset of Huntington's disease. Cell 162(3), pp. 516-526. (10.1016/j.cell.2015.07.003)
• Jones, L. et al. 2015. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia 11(6), pp. 658-671. (10.1016/j.jalz.2014.05.1757)
• Østergaard, S. D. et al. 2015. Associations between potentially modifiable risk factors and Alzheimer disease: A mendelian randomization study. PLOS MEDICINE 12(6), pp. e1001841., article number: e1001841. (10.1371/journal.pmed.1001841)
• Schmidts, M. et al. 2015. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications 6, article number: 7074. (10.1038/ncomms8074)
• Pocklington, A. et al. 2015. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86(5), pp. 1203-1214. (10.1016/j.neuron.2015.04.022)
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• Bulik-Sullivan, B. K. et al. 2015. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature Genetics 47(3), pp. 291-295. (10.1038/ng.3211)
• Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6, article number: 5681. (10.1038/ncomms6681)
• O'Dushlaine, C. et al. 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18(2), pp. 199-209. (10.1038/nn.3922)
• Maier, R. et al. 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics 96(2), pp. 283-294. (10.1016/j.ajhg.2014.12.006)
• Ruderfer, D. et al. 2015. No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia. European Journal of Human Genetics 23(4), pp. 555. (10.1038/ejhg.2014.228)
• Correia, K. et al. 2015. The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease. Journal of Huntington's Disease 4(3), pp. 279-284. (10.3233/JHD-150169)
• Rees, E. et al. 2015. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Translational Psychiatry 5(7), article number: e607. (10.1038/tp.2015.99)

2014

• Georgieva, L. et al. 2014. De novo CNVs in bipolar affective disorder and schizophrenia. Human Molecular Genetics 23(24), pp. 6677-6683. (10.1093/hmg/ddu379)
• Gusev, A. et al. 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95(5), pp. 535-552. (10.1016/j.ajhg.2014.10.004)
• Ruderfer, D. M. et al. 2014. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Molecular Psychiatry 19(9), pp. 1017-1024. (10.1038/mp.2013.138)
• Timpson, N. J. et al. 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications 5, article number: 4871. (10.1038/ncomms5871)
• Munafò, M. et al. 2014. Scientific rigor and the art of motorcycle maintenance. Nature Biotechnology 32(9), pp. 871-873. (10.1038/nbt.3004)
• Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
• Ripke, S. et al. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511(7510), pp. 421-427. (10.1038/nature13595)
• Erk, S. et al. 2014. Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects. NeuroImage 94, pp. 147-154. (10.1016/j.neuroimage.2014.03.007)
• Craddock, N. J. et al. 2014. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin 40(4), pp. 729-736. (10.1093/schbul/sbu069)
• Escott-Price, V. et al. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLoS ONE 9(6), article number: e94661. (10.1371/journal.pone.0094661)
• Liu, G. et al. 2014. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiology of Aging 35(4), pp. 786-92. (10.1016/j.neurobiolaging.2013.10.084)
• Fromer, M. et al. 2014. De novo mutations in schizophrenia implicate synaptic networks. Nature 506, pp. 179-184. (10.1038/nature12929)
• Duncan, L. E. et al. 2014. Pathway analyses implicate glial cells in schizophrenia. PLoS ONE 9(2), pp. -., article number: e89441. (10.1371/journal.pone.0089441)

2013

• Green, E. K. et al. 2013. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Molecular Psychiatry 18(12), pp. 1302-1307. (10.1038/mp.2012.142)
• van Scheltinga, A. F. T. et al. 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43(12), pp. 2563-2570. (10.1017/S0033291713000196)
• Lambert, J. et al. 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]. Nature Genetics 45(12), pp. 1452-1458. (10.1038/ng.2802)
• Lee, S. et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9), pp. 984-994. (10.1038/ng.2711)
• Ripke, S. et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45(10), pp. 1150-1159. (10.1038/ng.2742)
• Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
• Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
• Yang, L. et al. 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(5), pp. 419-430. (10.1002/ajmg.b.32169)
• Hamshere, M. L. et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular Psychiatry 18(6), pp. 708-712. (10.1038/mp.2012.67)
• Zou, F. et al. 2013. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's Disease pathology. PLoS ONE 8(5), article number: e64802. (10.1371/journal.pone.0064802)
• Terwisscha van Scheltinga, A. F. et al. 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73(6), pp. 525-531. (10.1016/j.biopsych.2012.08.017)
• Holmans, P. A. et al. 2013. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Human Molecular Genetics 22(5), pp. 1039-1049. (10.1093/hmg/dds492)
• Chapman, J. et al. 2013. A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Human Molecular Genetics 22(4), pp. 816-824. (10.1093/hmg/dds476)
• Escott-Price, V. et al. 2013. Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. JAMA Neurology 70(10), pp. 1268-1276. (10.1001/jamaneurol.2013.448)

2012

• Hollingworth, P. et al. 2012. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular Psychiatry 17(12), pp. 1316-1327. (10.1038/mp.2011.125)
• Eyre, S. et al. 2012. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics 44(12), pp. 1336-1340. (10.1038/ng.2462)
• Keller, M. F. et al. 2012. Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Human Molecular Genetics 21(22), pp. 4996-5009. (10.1093/hmg/dds335)
• Goes, F. S. et al. 2012. Genome-wide association of mood-incongruent psychotic bipolar disorder. Translational Psychiatry 2(10), article number: e180. (10.1038/tp.2012.106)
• Tansey, K. E. et al. 2012. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. Plos Medicine 9(10), article number: e1001326. (10.1371/journal.pmed.1001326)
• Levinson, D. F. et al. 2012. Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry 169(9), pp. 963-973. (10.1176/appi.ajp.2012.11091423)
• Hamilton, G. et al. 2012. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(6), pp. 696-709. (10.1002/ajmg.b.32073)
• Shi, H. et al. 2012. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging 33(8), article number: 1849.e5. (10.1016/j.neurobiolaging.2012.02.014)
• Hamilton, G. et al. 2012. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging 33(8), article number: 1848.e1. (10.1016/j.neurobiolaging.2012.02.005)
• Escott-Price, V., Schmidt, K. M., Vedernikov, A., Owen, M. J., Craddock, N. J., Holmans, P. A. and O'Donovan, M. C. 2012. Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. European Journal of Human Genetics 20(8), pp. 890-896. (10.1038/ejhg.2012.8)
• Le Foll, B. et al. 2012. Correction: ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS ONE 7(8) (10.1371/annotation/071abcbd-6f0c-4c4b-9507-dae42450457e)
• Jia, P. et al. 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology 8(7), article number: e1002587. (10.1371/journal.pcbi.1002587)
• Goes, F. S. et al. 2012. Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. Psychological Medicine 42(7), pp. 1449-1459. (10.1017/S0033291711002637)
• Derks, E. M. et al. 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis. PLoS ONE 7(6), article number: e37852. (10.1371/journal.pone.0037852)
• Sabunciyan, S. et al. 2012. Genome-Wide DNA methylation scan in major depressive disorder. PLoS ONE 7(4), article number: e34451. (10.1371/journal.pone.0034451)
• Hudson, G. et al. 2012. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78(14), pp. 1038-1042. (10.1212/WNL.0b013e31824e8f1d)
• Keller, M. C. et al. 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. Plos Genetics 8(4), article number: e1002656. (10.1371/journal.pgen.1002656)
• Simón-Sánchez, J. et al. 2012. Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's Disease. PLoS ONE 7(3), article number: e28787. (10.1371/journal.pone.0028787)
• Kirov, G. et al. 2012. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular Psychiatry 17(2), pp. 142-153. (10.1038/mp.2011.154)
• Jia, P. et al. 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics 49(2), pp. 96-103. (10.1136/jmedgenet-2011-100397)
• Richards, A. et al. 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17(2), pp. 193-201. (10.1038/mp.2011.11)
• Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
• Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
• Gerrish, A. et al. 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28(2), pp. 377-387. (10.3233/JAD-2011-110824)

2011

• Chen, J. et al. 2011. ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS ONE 6(12), article number: e28790. (10.1371/journal.pone.0028790)
• Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
• Cardno, A. G. et al. 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(8), pp. 929-940. (10.1002/ajmg.1404)
• Sklar, P. et al. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [Letter]. Nature Genetics 43(10), pp. 977-983. (10.1038/ng.943)
• Ripke, S. et al. 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43(10), pp. 969-976. (10.1038/ng.940)
• Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51.
• Escott-Price, V. et al. 2011. An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. Biological Psychiatry 70(2), pp. 198-203. (10.1016/j.biopsych.2011.01.034)
• Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51. (10.1016/j.schres.2011.06.023)
• Hollingworth, P. et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43(5), pp. 429-435. (10.1038/ng.803)
• Williams, H. J. et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry 16(4), pp. 429-441. (10.1038/mp.2010.36)
• O'Dushlaine, C. et al. 2011. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Molecular Psychiatry 16(3), pp. 286-292. (10.1038/mp.2010.7)
• Peterson, R. E. et al. 2011. Genetic risk sum score comprised of common polygenic variation is associated with body mass index. Human Genetics 129(2), pp. 221-230. (10.1007/s00439-010-0917-1)
• Reilly, M. P. et al. 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377(9763), pp. 383-392. (10.1016/S0140-6736(10)61996-4)
• Williams, H. J. et al. 2011. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics 20(2), pp. 387-391. (10.1093/hmg/ddq471)
• Bridges, M. et al. 2011. Genetic classification of populations using supervised learning. PLoS ONE 6(5), article number: e14802. (10.1371/journal.pone.0014802)
• Hamshere, M. L. et al. 2011. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry 198(4), pp. 284-288. (10.1192/bjp.bp.110.087866)
• Sims, R. et al. 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 764-771. (10.1002/ajmg.b.31216)
• Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 929-940. (10.1002/ajmg.b.31240)
• Escott-Price, V., O'Dushlaine, C., Purcell, S., Craddock, N. J., Holmans, P. A. and O'Donovan, M. C. 2011. Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. Genetic Epidemiology 35(8), pp. 861-866. (10.1002/gepi.20636)
• Dudbridge, F., Holmans, P. A. and Wilson, S. G. 2011. A flexible model for association analysis in sibships with missing genotype data. Annals of Human Genetics 75(3), pp. 428-438. (10.1111/j.1469-1809.2010.00636.x)
• Kendler, K. S. et al. 2011. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcoholism-Clinical and Experimental Research 35(5), pp. 963-975. (10.1111/j.1530-0277.2010.01427.x)
• Levinson, D. F. et al. 2011. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. American Journal of Psychiatry 168(3), pp. 302-316. (10.1176/appi.ajp.2010.10060876)
• Lips, E. S. et al. 2011. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Molecular Psychiatry, pp. 1-11. (10.1038/mp.2011.117)
• Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.

2010

• Carroll, L. S. et al. 2010. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular Psychiatry 15(11), pp. 1101-1111. (10.1038/mp.2009.96)
• Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15(11), pp. 1121-1121. (10.1038/mp.2010.62)
• Jones, L. et al. 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5(11), article number: e13950. (10.1371/journal.pone.0013950)
• Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
• Green, E. K. et al. 2010. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular Psychiatry 15(10), pp. 1016-1022. (10.1038/mp.2009.49)
• Allison, D. B. et al. 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics 6(9), article number: e1001097. (10.1371/journal.pgen.1001097)
• Escott-Price, V. et al. 2010. Genetic differences between five European populations. Human Heredity 70(2), pp. 141-149. (10.1159/000313854)
• Grozeva, D. et al. 2010. Rare copy number variants: A point of rarity in genetic risk for bipolar disorder and schizophrenia. Archives of General Psychiatry 67(4), pp. 318-327. (10.1001/archgenpsychiatry.2010.25)
• Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 15(2), pp. 146-153. (10.1038/mp.2008.66)
• Green, E. K. et al. 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(7), pp. 1347-1349. (10.1002/ajmg.b.31108)
• Dwyer, S. L., Williams, H., Holmans, P. A., Escott-Price, V., Craddock, N. J., Owen, M. J. and O'Donovan, M. C. 2010. No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(8), pp. 1411-1416. (10.1002/ajmg.b.31117)
• Holmans, P. A. 2010. Statistical methods for pathway analysis of genome-wide data for association with complex genetic traits. In: Moore, J. H. and Dunlap, J. C. eds. Computational Methods for Genetics of Complex Traits. Advances in Genetics Vol. 72. San Diego, CA: Academic Press, pp. 141-179., (10.1016/B978-0-12-380862-2.00007-2)
• Neale, B. M. et al. 2010. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 906-920. (10.1016/j.jaac.2010.06.007)
• Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
• Liu, Y. et al. 2010. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder [Letter]. Molecular Psychiatry 16(1), pp. 2-4. (10.1038/mp.2009.107)
• Shi, J. et al. 2010. Genome-wide association study of recurrent early-onset major depressive disorder. Molecular Psychiatry 16(2), pp. 193-201. (10.1038/mp.2009.124)

2009

• Harold, D. et al. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Letter]. Nature Genetics 41(10), pp. 1088-1093. (10.1038/ng.440)
• Shi, J. et al. 2009. Common variants on chromosome 6p22.1 are associated with schizophrenia [Letter]. Nature 460(7256), pp. 753-757. (10.1038/nature08192)
• Ng, M. Y. M. et al. 2009. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Molecular Psychiatry 14(8), pp. 774-785. (10.1038/mp.2008.135)
• Holmans, P. A. et al. 2009. Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. Molecular Psychiatry 14(8), pp. 786-795. (10.1038/mp.2009.11)
• Orozco, G. et al. 2009. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 18(14), pp. 2693-2699. (10.1093/hmg/ddp193)
• Holmans, P. A. et al. 2009. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American Journal of Human Genetics 85(1), pp. 13-24. (10.1016/j.ajhg.2009.05.011)
• Kirov, G. et al. 2009. Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Human Molecular Genetics 18(8), pp. 1497-1503. (10.1093/hmg/ddp043)
• Webster, J. A. et al. 2009. Genetic control of human brain transcript expression in Alzheimer Disease. American Journal of Human Genetics 84(4), pp. 445-458. (10.1016/j.ajhg.2009.03.011)
• Escott-Price, V. et al. 2009. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Molecular Psychiatry 14(3), pp. 252-260. (10.1038/mp.2008.133)
• O'Donovan, M. C. et al. 2009. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry 14(1), pp. 30-36. (10.1038/mp.2008.108)
• Hamshere, M. L. et al. 2009. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 195(1), pp. 23-29. (10.1192/bjp.bp.108.061424)
• Harold, D. et al. 2009. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Corrigendum]. Nature Genetics 41(10), pp. 1156. (10.1038/ng1009-1156d)
• Purcell, S. M. et al. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256), pp. 748-752. (10.1038/nature08185)
• Glaser, B. and Holmans, P. A. 2009. Comparison of methods for combining case-control and family-based association studies. Human Heredity 68(2), pp. 106-116. (10.1159/000212503)
• Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
• Hamshere, M. L. et al. 2009. Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31. Bipolar Disorders 11(6), pp. 610-620. (10.1111/j.1399-5618.2009.00736.x)
• Shyn, S. I. et al. 2009. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Molecular Psychiatry 16(2), pp. 202-215. (10.1038/mp.2009.125)
• Mahon, P. B. et al. 2009. Genome-wide linkage and follow-up association study of postpartum mood symptoms. American Journal of Psychiatry 166(11), pp. 1229-1237. (10.1176/appi.ajp.2009.09030417)

2008

• Barton, A. et al. 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40(10), pp. 1156-1159. (10.1038/ng.218)
• Ferreira, M. A. R. et al. 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40(9), pp. 1056-1058. (10.1038/ng.209)
• Barton, A. et al. 2008. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 17(15), pp. 2274-2279. (10.1093/hmg/ddn128)
• Loos, R. J. F. et al. 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40(6), pp. 768-775. (10.1038/ng.140)
• Fisher, S. A. et al. 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40(6), pp. 710-712. (10.1038/ng.145)
• Verma, R. et al. 2008. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. Biological psychiatry 63(12), pp. 1185-1189. (10.1016/j.biopsych.2008.02.005)
• Hodges, A. K., Hughes, G., Brooks, S. P., Elliston, L. A., Holmans, P. A., Dunnett, S. B. and Jones, L. 2008. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes, Brain and Behavior 7(3), pp. 288-299. (10.1111/j.1601-183X.2007.00350.x)
• Stone, J. L. et al. 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455(7210), pp. 237-241. (10.1038/nature07239)
• Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
• Blom, E. S. et al. 2008. Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(6), pp. 778-783. (10.1002/ajmg.b.30681)
• Irmansyah, . et al. 2008. Genome-wide scan in 124 Indonesian sib-pair families with Schizophrenia reveals genome-wide significant linkage to a locus on chromosome 3p26-21. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(7), pp. 1245-1252. (10.1002/ajmg.b.30763)
• Li, Y. et al. 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17(5), pp. 759-767. (10.1093/hmg/ddm348)
• Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
• O'Donovan, M. C. et al. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40(9), pp. 1053-1055. (10.1038/ng.201)
• Richards, A. L., Holmans, P. A., O'Donovan, M. C., Owen, M. J. and Jones, L. 2008. A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 9, article number: 490. (10.1186/1471-2105-9-490)

2007

• Glaser, B., Nikolov, I., Chubb, D., Hamshere, M. L., Segurado, R., Escott-Price, V. and Holmans, P. A. 2007. Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests [Conference Proceedings]. BMC Proceedings 1(S1), pp. S54-S54.
• Segurado, R., Hamshere, M. L., Glaser, B., Nikolov, I., Escott-Price, V. and Holmans, P. A. 2007. Combining linkage data sets for meta-analysis and mega-analysis: the GAW15 rheumatoid arthritis data set [Conference Proceedings]. BMC Proceedings 1(S1), pp. S104-S104.
• Hamshere, M. L., Segurado, R., Escott-Price, V., Nikolov, I., Glaser, B. and Holmans, P. A. 2007. Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis [Conference Proceedings]. BMC Proceedings 1(S1), pp. S100-S100.
• Nejentsev, S. et al. 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450(7171), pp. 887-892. (10.1038/nature06406)
• Verma, R. et al. 2007. Investigating the role ofp11 (S100A10) sequence variation in susceptibility to major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(8), pp. 1079-1082. (10.1002/ajmg.b.30514)
• Thomson, W. et al. 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39(12), pp. 1431-1433. (10.1038/ng.2007.32)
• Myers, A. J. et al. 2007. A survey of genetic human cortical gene expression. Nature Genetics 39(12), pp. 1494-1499. (10.1038/ng.2007.16)
• Strand, A. D. et al. 2007. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. Journal of Neuroscience 27(43), pp. 11758-11768. (10.1523/JNEUROSCI.2461-07.2007)
• Hollingworth, P. et al. 2007. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(7), pp. 841-848. (10.1002/ajmg.b.30515)
• Hamshere, M. L. et al. 2007. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics Advanc, pp. 1-34. (10.1093/hmg/ddm224)
• Jones, I. R. et al. 2007. Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16. American journal of psychiatry 164(7), pp. 1099-1104. (10.1176/appi.ajp.164.7.1099)
• Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
• Burton, P. R. et al. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), pp. 661-678. (10.1038/nature05911)
• Strand, A. D. et al. 2007. Conservation of regional gene expression in mouse and human brain. PLOS Genetics 3(4), article number: e59. (10.1371/journal.pgen.0030059)
• O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33(2), pp. 311-312. (10.1093/schbul/sbm004)
• Holmans, P. A. et al. 2007. Genetics of recurrent early-onset major depression (GenRED): final genome scan report. American Journal of Psychiatry 164(2), pp. 248-258. (10.1176/appi.ajp.164.2.248)
• Grupe, A. et al. 2007. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics 16(8), pp. 865-873. (10.1093/hmg/ddm031)
• Levinson, D. F. et al. 2007. Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers. American Journal of Psychiatry 164(2), pp. 259-264.
• Holmans, P. A. et al. 2007. Genetics of recurrent early-onset major depression (GenRED): final genome scan report. American Journal of Psychiatry 164(2), pp. 248-258.
• Ghosh, S., Babron, M., Group 10, ., Hamshere, M. L. and Holmans, P. A. 2007. Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience. Genetic Epidemiology 31(S1), pp. S86-S95. (10.1002/gepi.20284)
• Martin, L. J., Woo, J. G., Avery, C. L., Chen, H., North, K. E., Group 15, . and Holmans, P. A. 2007. Multiple testing in the genomics era: Findings from Genetic Analysis Workshop 15, Group 15. Genetic Epidemiology 31(S1), pp. S124-S131. (10.1002/gepi.20289)
• Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
• Burton, P. R. et al. 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39(11), pp. 1329-1337. (10.1038/ng.2007.17)

2006

• Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
• Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103(33), pp. 12469-12474. (10.1073/pnas.0603029103)
• Escott-Price, V., Craddock, N. J., Holmans, P. A., Owen, M. J. and O'Donovan, M. C. 2006. Effects of differential genotyping error rate on the Type 1 error probability of case-control studies. Human heredity 61(1), pp. 55-64. (10.1159/000092553)
• Hodges, A. K. et al. 2006. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15(6), pp. 965-977. (10.1093/hmg/ddl013)
• Grupe, A. et al. 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78(1), pp. 78-88.
• Smemo, S. et al. 2006. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology 59(1), pp. 21-26. (10.1002/ana.20673)
• Hamshere, M. L. et al. 2006. Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics 43(7), pp. 563-567. (10.1136/jmg.2005.035345)
• Macgregor, S., Craddock, N. J. and Holmans, P. A. 2006. Use of phenotypic covariates in association analysis by sequential addition of cases. European Journal of Human Genetics 14(5), pp. 529-534. (10.1038/sj.ejhg.5201604)

2005

• Hamshere, M. L., MacGregor, S., Escott-Price, V., Nikolov, I. N. and Holmans, P. A. 2005. Covariate linkage analysis of GAW14 simulated data incorporating subclinical phenotype, sex, population, parent-of-origin, and interaction. BMC Genetics 6(1), pp. S45. (10.1186/1471-2156-6-S1-S45)
• Levinson, D. F. and Holmans, P. A. 2005. The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees. BMC Genetics 6(1), pp. S6-S6. (10.1186/1471-2156-6-S1-S6)
• Hamshere, M. L. et al. 2005. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Archives of general psychiatry 62(10), pp. 1081-1088. (10.1001/archpsyc.62.10.1081)
• Hodges, A. et al. 2005. Regional specificity of transcriptional changes in early grade Huntington's disease brain. Journal of Neurology, Neurosurgery and Psychiatry 76, pp. A16-A16.
• Hughes, G. P. et al. 2005. Integrating behaviour and brain gene expression in Huntington's disease transgenic mouse models. Journal of Neurology, Neurosurgery and Psychiatry 76, pp. A41-A41.
• Nowotny, P. et al. 2005. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136B(1), pp. 62-68. (10.1002/ajmg.b.30186)
• Holmans, P. A. et al. 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B(1), pp. 24-32. (10.1002/ajmg.b.30114)
• Lambert, D. et al. 2005. Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. Molecular psychiatry 10(9), pp. 831-841. (10.1038/sj.mp.4001684)
• Cope, N. A. et al. 2005. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. American Journal of Human Genetics 76(4), pp. 581-591. (10.1086/429131)
• Escott-Price, V., Norton, N., Williams, N. M., Holmans, P. A., Owen, M. J. and O'Donovan, M. C. 2005. Streamlined analysis of pooled genotype data in SNP-based association studies. Genetic Epidemiology 28(3), pp. 273-282. (10.1002/gepi.20062)
• Li, Y. et al. 2005. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation 25(3), pp. 270-277. (10.1002/humu.20138)
• Escott-Price, V., Holmans, P. A., Schmidt, K. M. and Craddock, N. J. 2005. Design of Case-controls Studies with Unscreened Controls. Annals of Human Genetics 69(5), pp. 566-576. (10.1111/j.1529-8817.2005.00175.x)
• Seaman, S. R. and Holmans, P. A. 2005. Effect of genotyping error on type-I error rate of affected sib pair studies with genotyped parents. Human Heredity 59(3), pp. 157-164. (10.1159/000085939)

2004

• Li, Y. et al. 2004. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proceedings of the National Academy of Sciences 101(44), pp. 15688-15693. (10.1073/pnas.0403535101)
• Li, Y. et al. 2004. Association of ABCA1 with late-onset Alzheimer?s disease is not observed in a case-control study. Neuroscience Letters 366(3), pp. 268-271. (10.1016/j.neulet.2004.05.047)
• Mowry, B. J. et al. 2004. Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry 9(8), pp. 784-795. (10.1038/sj.mp.4001481)
• Holmans, P. A. et al. 2004. Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q. The American Journal of Human Genetics 74(6), pp. 1154-1167. (10.1086/421333)
• Bernardinelli, L., Berzuini, C., Seaman, S. and Holmans, P. A. 2004. Bayesian trio models for association in the presence of genotyping errors. Genetic Epidemiology 26(1), pp. 70-80. (10.1002/gepi.10291)
• Myers, A. J. et al. 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B(1), pp. 29-37. (10.1002/ajmg.b.20036)
• Busby, V. et al. 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5(2), pp. 133-146. (10.1385/NMM:5:2:133)

2003

• Williams, N. M. et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73(6), pp. 1355-1367. (10.1086/380206)
• Hensiek, A. et al. 2003. Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis. Journal of Neuroimmunology 143(1-2), pp. 25-30. (10.1016/j.jneuroim.2003.08.007)
• Levinson, D. F. et al. 2003. Genetics of recurrent early-onset depression (GenRED): Design and preliminary clinical characteristics of a repository sample for genetic linkage studies. American Journal of Medical Genetics 119B(1), pp. 118-130. (10.1002/ajmg.b.20009)
• Rice, K. M. and Holmans, P. A. 2003. Allowing for Genotyping Error in Analysis of Unmatched Case-Control Studies. Annals of Human Genetics 67(2), pp. 165-174. (10.1046/j.1469-1809.2003.00020.x)
• McInnis, M. G. et al. 2003. Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. Molecular Psychiatry 8(3), pp. 288-298. (10.1038/sj.mp.4001277)

2002

• Levinson, D. et al. 2002. Is schizophrenia linked to chromosome 1q? Response. Science 298(5602), pp. 2277-2279.
• Richards, A. J. et al. 2002. Vitreoretinopathy with phalangeal epiphyseal dysplasia, a type II collagenopathy resulting from a novel mutation in the C-propeptide region of the molecule. Journal of Medical Genetics 39(9), pp. 661-665. (10.1136/jmg.39.9.661)
• Akesson, E. et al. 2002. A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes and Immunity 3(5), pp. 279-285. (10.1038/sj.gene.6363866)
• Levinson, D. F. et al. 2002. No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 296(5568), pp. 739-741. (10.1126/science.1069914)
• Myers, A. et al. 2002. Full genome screen for Alzheimer disease: Stage II analysis. American Journal Of Medical Genetics Part A 114(2), pp. 235-244. (10.1002/ajmg.10183)
• Holmans, P. A. 2002. Detecting gene-gene interactions using affected sib pair analysis with covariates. Human Heredity 53(2), pp. 92-102. (10.1159/000057987)
• Bennett, P. et al. 2002. The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Molecular Psychiatry 7(2), pp. 189-200. (10.1038/sj.mp.4000957)

2001

• Holmans, P. A. 2001. Likelihood-ratio affected sib-pair tests applied to multiply affected sibships: issues of power and type I error rate. Genetic Epidemiology 20(1), pp. 44-56. (10.1002/1098-2272(200101))

2000

• Myers, A. et al. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290(5500), pp. 2304-2305. (10.1126/science.290.5500.2304)
• Levinson, D. F. et al. 2000. Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. American Journal of Human Genetics 67(3), pp. 652-663. (10.1086/303041)
• Murphy, K. C. et al. 2000. Chromosome 22q, velo-cardio-facial syndrome (VCFS) and schizophrenia. Journal of Medical Genetics 37, pp. S58-S58.
• Bandmann, O., Vaughan, J. R., Holmans, P. A., Marsden, C. D. and Wood, N. W. 2000. Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease. Movement Disorders 15(1), pp. 30-35. (10.1002/1531-8257(200001)15:13.0.CO;2-V)
• Neuman, R. J., Saccone, N. L., Holmans, P. A., Rice, J. P. and Sun, L. 2000. Clustering methods applied to allele sharing data. Genetic Epidemiology 19(1), pp. 57-63. (10.1002/1098-2272(2000)19:1+<::AID-GEPI9>3.0.CO;2-D)

1999

• Williams, N. M. et al. 1999. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Human Molecular Genetics 8(9), pp. 1729-1739. (10.1093/hmg/8.9.1729)
• Wavrant-De Vrieze, F. et al. 1999. Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease. Neuroscience Letters 269(2), pp. 67-70.
• Hateboer, N., Lazarou, L. P., Williams, A. J., Holmans, P. A. and Ravine, D. 1999. Familial phenotype differences in PKD11. Kidney International 56(1), pp. 34-40. (10.1046/j.1523-1755.1999.00541.x)
• Rees, M. I. et al. 1999. Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry 4(4), pp. 353-359. (10.1038/sj.mp.4000521)
• Wavrant-DeVrieze, F. et al. 1999. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters 262(2), pp. 137-139. (10.1016/S0304-3940(99)00035-X)
• Kehoe, P. et al. 1999. A full genome scan for late onset Alzheimer's disease. Human Molecular Genetics 8(2), pp. 237-245. (10.1093/hmg/8.2.237)
• Bandmann, O., Vaughan, J., Holmans, P. A., Marsden, C. D. and Wood, N. W. 1999. Toxins, genetics, and Parkinson's disease: the role of N-acetyltransferase 2. Advances in Neurology -New York- Raven Press- 80, pp. 199-204.

1998

• Holmans, P. A. 1998. Affected sib-pair methods for detecting linkage to dichotomous traits: review of the methodology. Human biology 70(6), pp. 1025-1040.
• Kehoe, P. G., Williams, H., Holmans, P. A., Wilcock, G., Cairns, N. J., Neal, J. and Owen, M. J. 1998. The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. Journal of Medical Genetics 35(12), pp. 1034-1035. (10.1136/jmg.35.12.1034)
• Bandmann, O. et al. 1998. Dopa-responsive dystonia: a clinical and molecular genetic study. Annals of Neurology 44(4), pp. 649-656. (10.1002/ana.410440411)
• Wu, W. S. et al. 1998. Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA - The Journal of the American Medical Association 280(7), pp. 619-622. (10.1001/jama.280.7.619)
• Daniels, J., Holmans, P. A., Williams, N. M., Turic, D., McGuffin, P., Plomin, R. and Owen, M. J. 1998. A simple method for analyzing microsatellite allele image patterns generated from DNA pools and its application to allelic association studies. American Journal of Human Genetics 62(5), pp. 1189-1197. (10.1086/301816)
• Williams, J. et al. 1998. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Molecular Psychiatry 3(2), pp. 141-149.
• Holmans, P. A. and Craddock, N. J. 1998. Efficient strategies for genome scanning with affected sib pairs - Reply. American Journal of Human Genetics 62(1), pp. 205-207. (10.1086/301683)
• Hateboer, N., Lazarou, L., Holmans, P. A., Williams, A. J. and Ravine, D. 1998. Inter-family variability of phenotype in autosomal dominant polycystic kidney disease type 1. European Journal of Human Genetics 6(1), pp. 71-71.
• Murphy, K. C., Williams, N. M., Cardno, A. G., Jones, L. A., Holmans, P. A., McGuffin, P. and Owen, M. J. 1998. A linkage study of chromosome 22q in SIB-pairs with schizophrenia. Schizophrenia Research 29(1-2), pp. 131-132. (10.1016/S0920-9964(97)88632-X)
• Spurlock, G. et al. 1998. A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Molecular Psychiatry 3(1), pp. 42-49. (10.1038/sj.mp.4000342)

1997

• Bandmann, O., Vaughan, J., Holmans, P. A., Marsden, C. D. and Wood, N. W. 1997. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. The Lancet 350(9085), pp. 1136-1139. (10.1016/S0140-6736(97)03495-8)
• Hateboer, N. et al. 1997. PKD2: The phenotype defined. Kidney International 52(4), pp. 1122-1122.
• Baboolal, K., Ravine, D., Daniels, J., Williams, N. M., Holmans, P. A., Coles, G. A. and Williams, J. D. 1997. Association of the angiotensin I converting enzyme gene deletion polymorphism with early onset of ESRF in PKD1 adult polycystic kidney disease. Kidney International 52(3), pp. 607-613. (10.1038/ki.1997.373)
• Hateboer, N. et al. 1997. Phenotype PKD2 vs. PKD1; results from the European concerted action.. Journal of the American Society of Nephrology 8, pp. A1722-A1722.
• Rees, M. et al. 1997. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Molecular Psychiatry 2(5), pp. 398-402. (10.1038/sj.mp.4000256)
• Owen, M. J., Holmans, P. A. and McGuffin, P. 1997. Association studies in psychiatric genetics. Molecular Psychiatry 2(4), pp. 270-273. (10.1038/sj.mp.4000292)
• Daniels, J. K. et al. 1997. Linkage study of chromosome 6p in sib-pairs with schizophrenia. American Journal of Medical Genetics 74(3), pp. 319-323. (10.1002/(SICI)1096-8628(19970531)74:3<319::AID-AJMG14>3.0.CO;2-R)
• Holmans, P. A. and Craddock, N. J. 1997. Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis. American Journal of Human Genetics 60(3), pp. 657-666.

1996

• Levinson, D. F. et al. 1996. Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. American Journal of Medical Genetics 67(6), pp. 580-594. (10.1002/(SICI)1096-8628(19961122)67:6<580::AID-AJMG11>3.0.CO;2-P)
• Kehoe, P. et al. 1996. Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease. NeuroReport 7(13), pp. 2155-2158. (10.1097/00001756-199609020-00019)
• Asherson, P. et al. 1996. Linkage, association and mutational analysis of the dopamine D3 receptor gene in schizophrenia. Molecular Psychiatry 1(2), pp. 125-132.
• Craddock, N. J., Daniels, J., Holmans, P. A., Williams, N. M. and Owen, M. J. 1996. Increasing the efficiency of genomic searches for linkage in complex disorders by DNA pooling of affected sib-pairs. Molecular Psychiatry 1(1), pp. 59-64.
• Gill, M. et al. 1996. A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22).. American Journal of Medical Genetics 67(1), pp. 40-45. (10.1002/(SICI)1096-8628(19960216)67:1<40::AID-AJMG6>3.0.CO;2-W)
• Cardno, A., Holmans, P. A., Harvey, I., Williams, M. B., Owen, M. J. and McGuffin, P. 1996. Factor-derived subsyndromes of schizophrenia and familial morbid risks. Schizophrenia Research 18(2-3), pp. IVA2-IVA2.

1995

• Roberts, A. G. et al. 1995. Partial characterization and assignment of the gene for protoporphyrinogen oxidase and variegate porphyria to human chromosome 1q23. Human Molecular Genetics 4(12), pp. 2387-2390. (10.1093/hmg/4.12.2387)
• Holmans, P. A. and Clayton, D. 1995. Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers. American Journal of Human Genetics 57(5), pp. 1221-1232.
• Wood, N. W., Sawcer, S. J., Kellar-Wood, H. F., Holmans, P. A., Clayton, D., Robertson, N. and Compston, D. A. 1995. The T-cell receptor beta locus and susceptibility to multiple sclerosis. Neurology 45(10), pp. 1859-1863. (10.1212/WNL.45.10.1859)
• Wood, N. W., Sawcer, S. J., Kellar-Wood, H. F., Holmans, P. A., Clayton, D., Robertson, N. and Compston, D. A. 1995. Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region. Journal of Neurology 242(10), pp. 677-682. (10.1007/BF00866919)
• Kellar-Wood, H. F., Wood, N. W., Holmans, P. A., Clayton, D., Robertson, N. and Compston, D. A. 1995. Multiple sclerosis and the HLA-D region: linkage and association studies. Journal of Neuroimmunology 58(2), pp. 183-190. (10.1016/0165-5728(95)00015-T)
• Holmans, P. A., McGuffin, P. and Clayton, D. 1995. Genome scan for association and linkage. Genetic Epidemiology 12(6), pp. 613-618. (10.1002/gepi.1370120615)
• Robertson, N., Wood, N., Holmans, P. A., Kellar-Wood, H. F., Sawcer, S. and Wood, N. W. 1995. Strategies for the identification of susceptibility genes in multiple sclerosis [Editorial]. The International Ms Journal 2, pp. 19-28.

1994

• Wood, N. W., Holmans, P. A., Clayton, D., Robertson, N. P. and Compston, D. A. 1994. No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs. Journal of Neurology, Neurosurgery & Psychiatry 57(10), pp. 1191-1194. (10.1136/jnnp.57.10.1191)
• Eoli, M., Wood, N., Kellar-Wood, H., Holmans, P. A., Clayton, D. and Compston, D. 1994. No linkage between multiple sclerosis and the T cell receptor alpha chain locus. Journal of the Neurological Sciences 124(1), pp. 32. (10.1016/0022-510X(94)90007-8)

1993

• Holmans, P. A. 1993. Asymptotic properties of affected-sib-pair linkage analysis. American journal of human genetics 52(2), pp. 362-374.