![Matthew Ivory](https://profiles-cardiff.imgix.net/attachments/2925?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Matthew Ivory
Lecturer
Overview
Qualifications
- PhD: School of Pharmacy and Pharmaceutical Sciences, Cardiff University (2016)
- GPhC: Professional registration (2012)
- Pharmacy degree (MPharm): First Class Honours, Cardiff University (2011)
Publication
2019
- Maarifi, G. et al. 2019. Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cellular and Molecular Immunology 17, pp. 547-549. (10.1038/s41423-019-0302-5)
2016
- Czubala, M. A. et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123)
- Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033)
- Ivory, M. O. 2016. Characterising skin immune cells to inform development of intradermal vaccines and therapeutics. PhD Thesis, Cardiff University.
2015
- Ivory, M. O., Birchall, J. C. and Piguet, V. 2015. Early dengue virus infection in human skin: a cycle of inflammation and infectivity [Commentary]. Journal of Investigative Dermatology 135(7), pp. 1711-1712. (10.1038/jid.2014.544)
2010
- Pearton, M. et al. 2010. Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin. Vaccine 28(37), pp. 6104-6113. (10.1016/j.vaccine.2010.05.055)
- Pearton, M., Kang, S. M., Song, J. M., Anstey, A. V., Ivory, M. O., Compans, R. W. and Birchall, J. C. 2010. Changes in human Langerhans cells following intradermal injection of influenza virus-like particle vaccines. PLoS ONE 5(8), article number: e12410. (10.1371/journal.pone.0012410)
Articles
- Maarifi, G. et al. 2019. Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cellular and Molecular Immunology 17, pp. 547-549. (10.1038/s41423-019-0302-5)
- Czubala, M. A. et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123)
- Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033)
- Ivory, M. O., Birchall, J. C. and Piguet, V. 2015. Early dengue virus infection in human skin: a cycle of inflammation and infectivity [Commentary]. Journal of Investigative Dermatology 135(7), pp. 1711-1712. (10.1038/jid.2014.544)
- Pearton, M. et al. 2010. Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin. Vaccine 28(37), pp. 6104-6113. (10.1016/j.vaccine.2010.05.055)
- Pearton, M., Kang, S. M., Song, J. M., Anstey, A. V., Ivory, M. O., Compans, R. W. and Birchall, J. C. 2010. Changes in human Langerhans cells following intradermal injection of influenza virus-like particle vaccines. PLoS ONE 5(8), article number: e12410. (10.1371/journal.pone.0012410)
Thesis
- Ivory, M. O. 2016. Characterising skin immune cells to inform development of intradermal vaccines and therapeutics. PhD Thesis, Cardiff University.
Research
Research interests
Delivery of vaccines and therapeutics into the skin
Human skin represents an ideal target for the delivery of therapeutics due to its accessibility and avoidance of first pass metabolism. In particular, the delivery of vaccines intradermally can take advantage of the diverse populations of immune cells present to allow for immunisation with reduced antigen doses compared to the practiced intramuscular injection route. The multiple subsets of human dermal dendritic cells and their roles in the uptake, processing and presentation of vaccine antigen to elicit immune responses alongside epidermal Langerhans cells are still under debate and so research in this area is vital to inform future vaccine design.
Teaching
MPharm undergraduate teaching
- PH1122 - The Role of The Pharmacist in Professional Practice (module leader)
- PH1123 - Structure and Function of Cells and Microbes
- PH2107 - Formulation Science I
- PH3114 - Design, Formulation and Quality Assurance of Medicinal Products
- PH4116 - Pharmacy Research or Scholarship Project
- PH4118 - Pharmaceutical Sciences, Pharmacy Practice and the Patient
Biography
Career profile
- July 2016 - Present Lecturer, School of Pharmacy and Pharmaceutical Sciences, Cardiff University.
- September 2015 - October 2015 Visiting Researcher, Department of Immunology and Cell Biology, Osaka University, Japan.
- October 2012 - September 2016 Postgraduate Research Student, School of Pharmacy and Pharmaceutical Sciences, Cardiff University.
- Aug 2012 - Present Locum Pharmacist, various locations.
- Aug 2011 - Jul 2012 Pre-Registration Pharmacist, Bristol-Myers Squibb and St Helens and Knowsley Teaching Hospitals NHS Trust, Merseyside.
- September 2007 - July 2011 Undergraduate Student (MPharm), School of Pharmacy and Pharmaceutical Sciences, Cardiff University.
Key Expertise
- Ex vivo human skin organ culture and histology (immunohistochemistry and immunofluorescence)
- Human skin immune cell extraction and culture
- Flow cytometry
- Pharmaceutical formulation
