![Arwyn Jones](https://profiles-cardiff.imgix.net/attachments/2933?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Arwyn Jones
(he/him)
- Welsh speaking
- Media commentator
- Available for postgraduate supervision
Teams and roles for Arwyn Jones
Professor of Membrane Traffic and Drug Delivery and Deputy Head Research Innovation and Engagement
Overview
I joined the School of Pharmacy and Pharmaceutical Sciences at Cardiff University as a lecturer in 2001 and now serve as Professor of Membrane Traffic and Drug Delivery and in 2018 I became the Director of Research Innovation and Engagement for the School. Previously I gained my PhD in protein biochemistry and crystallography at Birkbeck College, University of London, and undertook postdoctoral positions investigating membrane traffic on the endocytic pathway at the Physiological Laboratory, University of Liverpool and the Harvard School of Public Health, Harvard University, USA.
In 2000 I was awarded a European Molecular Biology Organisation Fellowship to work at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany and continued at the EMBL when I was awarded an Alexander von Humboldt Foundation Scholarship.
I have a keen interest in the public understanding of science, especially through the medium of Welsh, and in 2001 was awarded a Diploma in Journalism from the University of Wales Bangor. Since then I have been very active in science outreach activities and have organised several large science exhibitions at the National Eisteddfod of Wales - see below for Public Engagement with Science.
I am a member of the School's research themes:
- Drug Discovery, Pharmaceutical Sciences and Experimental Therapeutics
- Medicines Optimisation & Healthcare Outcomes
I have a major interest in endocytosis and cellular delivery of therapeutic macromolecules. My current projects fall under the overall themes of regulation of endocytosis and endocytic pathways:
- Targeting and endocytosis of plasma membrane receptors
- Polymeric conjugates as drug delivery vectors
- Cell penetrating peptides as drug delivery vectors
- Breast cancer cell biology
Public engagement with science
I am very active in public engagement in science, and have gained funding from both the Wellcome Trust and EPSRC to set up large public engagement activities. I regularly contribute to BBC, S4C and Radio Cymru news programmes and am also engaged in discussing other aspects of science on TV and radio. I also visit local schools and colleges to showcase science. Here are some outreach highlights:
- Marvellous kidneys: How kidneys clean our blood and keep us healthy at the Urdd Eisteddfod in Margam, May 2025
- Pharmabees, drug design from bench to bedside at the National Eisteddfod in Pontypridd, August 2024
- Pharmabees, from bench to bedside at the Urdd Eisteddfod in Meifod, June 2024
- Carbon capture and photosynthesis display at the National Eisteddfod in Llyn, August 2023
- Carbon capture at the Urdd Eisteddfod in Llandovery, May 2023
- Bioaccumulation display launched at National Eisteddfod in Tregaron, August 2022
- New public engagement project travels to the Urdd Eisteddfod in Dinbych, May 2022
- School of Pharmacy brings The Science of Medicines to the National Eisteddfod in Llanrwst, August 2019
- Cardiff School of Pharmacy bring science education to the National Eisteddfod of Wales, August 2018
- Life Science Research Network and Cardiff University take science to the Urdd Eisteddfod, May 2017
- Bouncing brain at the National Eisteddfod of Wales, August 2016
- STEM day students visit Pharmacy, May 2016
- Cancer Research Open Day, Cardiff University, October 2015
- Working Polymers exhibition at the National Eisteddfod of Wales Meifod, August 2015
- STEM day, Cardiff University, June 2015
- Cancer Research Open Day, 2014
- Science and technology pavilion at the National Eisteddfod of Wales in Llanelli, August 2014
In 2010 and 2011 I led a Public Engagement project sponsored by the EPSRC to highlight the multidisciplinary science involved in, and potential of, tissue engineering. This £55K Partnership for Public Engagement Award "Tissue Engineering for Human Healing" was obtained with Dr Bob Steadman (MEDIC) and Dr Pete Griffiths (CHEMY) and involved setting up tissue engineering exhibits and activities at various locations in Wales and was launched at the 2010 National Eisteddfod of Wales in Ebbw Vale. Included there, and in the following year at the National Eisteddfod in Wrexham, were a wide range of interactive and educational activities housed in the Eisteddfod Science Pavilion. These included a life sized Operation game, maggot races and a Stem Cell puzzle. The Stem Cell puzzle will now be a regular feature at the Techniquest science centre in Cardiff Bay.
Publication
2026
- Newman, C. et al., 2026. Mechanism of uptake and toxicity of a BCMA antibody drug conjugate with a MMAF payload by nonantigen expressing cells. Cell Biology and Toxicology 42 86. (10.1007/s10565-026-10183-2)
- Hughes, C. S. et al. 2026. Rapid plasma membrane reorganisation and endocytosis in HER2 breast cancer cells incubated with trastuzumab decorated polymer nanoparticles. RSC Pharmaceutics 3 (2), pp.390-400. (10.1039/d5pm00168d)
2025
- Almehdi, A. M. et al., 2025. Next-generation Bcl-2 inhibitors: design and evaluation of indolyl-triazole derivatives with anticancer potential. ChemMedChem 20 e202500265. (10.1002/cmdc.202500265)
- Alsulaimany, M. et al. 2025. Exploring long arm amide-linked side chains in the design of antifungal azole inhibitors of sterol 14α-demethylase (CYP51). Journal of Medicinal Chemistry 68 (11), pp.10781-10799. (10.1021/acs.jmedchem.4c02922)
2024
- Truyts, A. et al., 2024. Application of monoclonal anti-mycolate antibodies in serological diagnosis of tuberculosis. Tropical Medicine and Infectious Disease 9 (11), pp.269. (10.3390/tropicalmed9110269)
- Rizzo, S. et al. 2024. Modification of the antibiotic, colistin, with dextrin causes enhanced cytotoxicity and triggers apoptosis in myeloid leukemia. International Journal of Nanomedicine 19 , pp.5419-5437. (10.2147/IJN.S449185)
- Varache, M. et al. 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics 1 , pp.68-79. (10.1039/D3PM00014A)
2023
- Hunter, M. R. et al., 2023. Understanding Intracellular Biology to Improve mRNA Delivery by Lipid Nanoparticles. small methods 2201695. (10.1002/smtd.202201695)
- Lambourne, O. A. et al. 2023. PINK1-Dependent mitophagy inhibits elevated ubiquitin phosphorylation caused by mitochondrial damage. Journal of Medicinal Chemistry 66 (11), pp.7645-7656. (10.1021/acs.jmedchem.3c00555)
- Birch, D. et al., 2023. Stereoisomer-dependent membrane association and capacity for insulin delivery facilitated by Penetratin. Pharmaceutics 15 (6) 1672. (10.3390/pharmaceutics15061672)
- Daniele, R. et al., 2023. Influence of folate-targeted gold nanoparticles on subcellular localization and distribution into lysosomes. Pharmaceutics 15 (3) 864. (10.3390/pharmaceutics15030864)
2022
- Griffiths, G. et al., 2022. Nanoparticle entry into cells; the cell biology weak link. Advanced Drug Delivery Reviews 188 114403. (10.1016/j.addr.2022.114403)
- Allemann, R. K. et al. 2022. Spatio-temporal control of cell death by selective delivery of photo-activatable proteins. ChemBioChem 23 (12) e202200115. (10.1002/cbic.202200115)
- Aikman, B. et al., 2022. Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies. Dalton Transactions 51 (19), pp.7476-7490. (10.1039/D2DT00337F)
- Sayers, E. J. et al. 2022. Fluid-phase endocytosis and lysosomal degradation of bovine lactoferrin in lung cells. Pharmaceutics 14 (4) 855. (10.3390/pharmaceutics14040855)
- Gurney, L. et al., 2022. Strategies for peptide-mediated cargo delivery to human smooth muscle cells. In: Langel, U. ed. Cell Penetrating Peptides. Vol. 2383, Methods in Molecular Biology book series Springer. , pp.459-471. (10.1007/978-1-0716-1752-6_29)
- Sayers, E. J. et al. 2022. Quantitative subcellular analysis of cyclic cell-penetrating peptide EJP18 in nonadherent cells. In: Cell Penetrating Peptides. Vol. 2383, Methods in Molecular Biology book series Springer. , pp.211-228. (10.1007/978-1-0716-1752-6_14)
2021
- Padalino, G. et al. 2021. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry 226 113823. (10.1016/j.ejmech.2021.113823)
- Hamdy, R. et al., 2021. New bioactive fused triazolothiadiazoles as Bcl-2-targeted anticancer agents. International Journal of Molecular Sciences 22 (22) 12272. (10.3390/ijms222212272)
- Mills, E. M. et al. 2021. Development of mammalian cell logic gates controlled by unnatural amino acids. Cell Reports Methods 1 (6) 100073. (10.1016/j.crmeth.2021.100073)
- Herkert, E. et al., 2021. Roadmap on bio-nano-photonics. Journal of Optics 23 (7) 073001. (10.1088/2040-8986/abff94)
2020
- Hamdy, R. et al., 2020. Design, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting Bcl-2. International Journal of Molecular Sciences 21 (23) 8980. (10.3390/ijms21238980)
- Nödling, A. et al. 2020. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chemical Communications 56 (34), pp.4672-4675. (10.1039/C9CC07931A)
- Wymant, J. M. et al., 2020. Strategic trastuzumab mediated crosslinking driving concomitant HER2 and HER3 endocytosis and degradation in breast cancer. Journal of Cancer 11 (11), pp.3288-3302. (10.7150/jca.32470)
- Giannakopoulou, N. et al. 2020. Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells. Nanoscale 12 (7), pp.4622-4635. (10.1039/C9NR08512B)
- Eissa, N. et al. 2020. EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide. Biochemical Journal 477 (1), pp.45-60. (10.1042/BCJ20190452)
2019
- Sayers, E. J. et al. 2019. Endocytic profiling of cancer cell models reveals critical factors influencing lipid nanoparticle mediated mRNA delivery and protein expression. Molecular Therapy 27 (11), pp.1950-1962. (10.1016/j.ymthe.2019.07.018)
- Woods, B. et al. 2019. Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells. Journal of Inorganic Biochemistry 199 110781. (10.1016/j.jinorgbio.2019.110781)
- Lorenzer, C. et al., 2019. Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics 141 , pp.37-50. (10.1016/j.ejpb.2019.05.015)
- Wahlich, J. et al., 2019. Nanomedicines for the delivery of biologics. Pharmaceutics 11 (5) 210. (10.3390/pharmaceutics11050210)
- Patel, S. G. et al. 2019. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Scientific Reports 9 (1), pp.-. 6298. (10.1038/s41598-019-42456-8)
- Hamdy, R. et al., 2019. New quinoline-based heterocycles as anticancer agents targeting Bcl-2. Molecules 24 (7), pp.1274. (10.3390/molecules24071274)
2018
- Gurney, L. R. I. et al., 2018. Inhibition of inflammatory changes in human myometrial cells by cell penetrating peptide and small molecule inhibitors of NFκB. Frontiers in Immunology 9 2966. (10.3389/fimmu.2018.02966)
- Sasso, L. et al., 2018. Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials. Journal of Interdisciplinary Nanomedicine 3 (2), pp.67-81. (10.1002/jin2.39)
- He, L. et al. 2018. Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates. Scientific Reports 8 (1) 7318. (10.1038/s41598-018-25600-8)
- Sayers, E. J. et al. 2018. Switching of macromolecular ligand display by thermoresponsive polymers mediates endocytosis of multi-conjugate nanoparticles. Bioconjugate Chemistry 29 (4), pp.1030-1046. (10.1021/acs.bioconjchem.7b00704)
2017
- Kjos, I. et al., 2017. Rab7b modulates autophagic flux by interacting with Atg4B. EMBO reports 18 (10), pp.1727-1739. (10.15252/embr.201744069)
- Roberts-Dalton, H. D. et al. 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9 (36), pp.13693-13706. (10.1039/C7NR04128D)
- Brazzale, C. et al., 2017. Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells. Nanoscale 9 (31), pp.11137-11147. (10.1039/C7NR02595E)
- Hamdy, R. et al., 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27 (4), pp.1037-1040. (10.1016/j.bmcl.2016.12.061)
- Ziedan, N. I. et al., 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design (10.1111/cbdd.12936)
- Wymant, J. et al. 2017. Poster 433: Receptor-antibody clustering induced endocytosis of HER2 has therapeutic potential in breast cancer. Presented at: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimising Immuno and Targeted Therapies From Cancer Biology to the Clinic Florence, Italy 24-27 June 2017.
2016
- Wymant, J. et al. 2016. The Role of BCA2 in the endocytic trafficking of EGFR and significance as a prognostic biomarker in cancer. Journal of Cancer 7 (15), pp.2388-2407. (10.7150/jca.15055)
- Kandil, S. et al. 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110 , pp.311-325. (10.1016/j.ejmech.2015.12.037)
- Gurney, L. R. I. et al., 2016. Use of cell penetrating peptides to treat inflammatory responses in human uterine cells. Reproductive Sciences 23 , pp.292A-292A. S-073. (10.1177/1933719116641257)
2015
- Moody, P. R. et al. 2015. Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy 23 (12), pp.1888-1898. (10.1038/mt.2015.178)
- Lemmer, Y. et al., 2015. Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis. Journal of Controlled Release 211 , pp.94-104. (10.1016/j.jconrel.2015.06.005)
- Cilibrasi, V. et al. 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20), pp.2583-2585. (10.1016/j.tetlet.2015.03.132)
- Pereira, P. et al., 2015. siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate functionalized glycol chitosan nanogels. Molecular Pharmaceutics 12 (6), pp.1970-1979. 150416105321008. (10.1021/mp500785t)
- Wiggins, H. L. et al. 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93 (3), pp.332-342. (10.1016/j.bcp.2014.12.014)
- Webber, J. P. et al. 2015. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 (3), pp.290-302. (10.1038/onc.2013.560)
- Bahnsen, J. S. et al., 2015. Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. Pharmaceutical Research 32 (5), pp.1546-1556. (10.1007/s11095-014-1550-9)
- He, L. , Watson, P. D. and Jones, A. T. 2015. Visualizing actin architectures in cells incubated with cell-penetrating peptides. In: Langel, U. ed. Cell-Penetrating Peptides: Methods and Protocols. Vol. 1324, Methods in Molecular Biology Vol. 1324.Springer. , pp.247-259. (10.1007/978-1-4939-2806-4_16)
2014
- Sayers, E. J. et al. 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195 , pp.55-62. (10.1016/j.jconrel.2014.07.055)
2013
- Cleal, K. et al. 2013. Endocytosis, intracellular traffic and fate of cell penetrating peptide based conjugates and nanoparticles. Current Pharmaceutical Design 19 (16), pp.2878-2894. (10.2174/13816128113199990297)
- Hamdy, R. et al., 2013. Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. Biorganic and Medicinal Chemistry Letters 23 (8), pp.2391-2394. (10.1016/j.bmcl.2013.02.029)
- Kothayer, H. et al., 2013. Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Biorganic and Medicinal Chemistry Letters 23 (24), pp.6886-6889. (10.1016/j.bmcl.2013.09.087)
- Mart, R. J. et al. 2013. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells. Molecular BioSystems 9 (11), pp.2597-2603. (10.1039/c3mb70246d)
2012
- Al Soraj, M. et al., 2012. siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat. Journal of Controlled Release 161 (1), pp.132-141. (10.1016/j.jconrel.2012.03.015)
- Bailey, D. et al., 2012. An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases. Acta Crystallographica Section D: Biological Crystallography 68 (5), pp.541-552. (10.1107/S0907444912004817)
- Jones, A. T. and Sayers, E. J. 2012. Cell entry of cell penetrating peptides and tales of tails wagging dogs. Journal of Controlled Release 161 (2), pp.582-591. (10.1016/j.jconrel.2012.04.003)
2011
- Watkins, C. L. et al., 2011. Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular Therapy 19 (12), pp.2124-2132. (10.1038/mt.2011.175)
- Vercauteren, D. et al., 2011. Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines. ACS Nano 5 (10), pp.7874-7884. (10.1021/nn2020858)
- Fricke, T. et al. 2011. Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins. Bioconjugate Chemistry 22 (9), pp.1763-1767. (10.1021/bc200338u)
- Vercauteren, D. et al., 2011. Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes. Biomaterials 32 (11), pp.3072-3084. (10.1016/j.biomaterials.2010.12.045)
2010
- Al-Soraj, M. H. et al., 2010. siRNA versus pharmacological inhibition of endocytic pathways for studying cellular uptake of cell penetrating peptides and other drug delivery vectors. Drug Discovery Today 15 (23-24), pp.1103-1103. (10.1016/j.drudis.2010.09.411)
- Bruyere, H. , Westwell, A. and Jones, A. T. 2010. Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorganic & Medicinal Chemistry Letters 20 (7), pp.2200-2203. (10.1016/j.bmcl.2010.02.035)
- Fricke, T. et al. 2010. Click chemistry for the generation of cell permeable apoptotic peptides. Drug Discovery Today 15 (23-24), pp.1088-1088. (10.1016/j.drudis.2010.09.375)
- Gumbleton, M. and Jones, A. T. 2010. Cellular delivery of therapeutic macromolecules (CDTM) international Symposium 2010: lessons and progress from inter-disciplinary science. Drug Discovery Today 15 (23-24), pp.1079-180. (10.1016/j.drudis.2010.10.010)
- Jones, A. T. 2010. Uptake and intracellular dynamics of proteins internalized by cell-penetrating peptides. In: Weissig, V. and D'Souza, G. G. M. eds. Organelle-Specific Pharmaceutical Nanotechnology. Hoboken, NJ.: John Wiley & Sons. , pp.263-288. (10.1002/9780470875780.ch15)
- Sweeney, M. et al., 2010. Octaarginine mediated delivery of fluorescent cargo to human smooth muscle cells. Drug Discovery Today 15 (23-24), pp.1085-1085. (10.1016/j.drudis.2010.09.367)
- Vercauteren, D. et al., 2010. The use of inhibitors to study endocytic pathways of gene carriers: Optimization and pitfalls. Molecular Therapy 18 (3), pp.561-569. (10.1038/mt.2009.281)
2009
- Watkins, C. L. et al. 2009. Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. Journal of Controlled Release 140 (3), pp.237-244. (10.1016/j.jconrel.2009.04.028)
- Watkins, C. L. et al. 2009. Low concentration thresholds of plasma membranes for rapid energy-independent translocation of a cell-penetrating peptide. Biochemical Journal 420 (2), pp.179-189. (10.1042/BJ20090042)
- Hughes, M. L. , John, D. N. and Jones, A. T. 2009. Information provided with dispensed medicines: What role does language choice play? A perspective from Wales [Abstract]. International Journal of Pharmacy Practice 17 (S2), pp.B44-B45. (10.1211/096176709789037128)
- Hughes, M. L. et al. 2009. Language issues in the community pharmacy: a perspective from Wales. International Journal of Pharmacy Practice 17 (3), pp.157-163. (10.1211/ijpp.17.03.0006)
- Hughes, M. L. , John, D. N. and Jones, A. T. 2009. Medicines use reviews and language choice. International Journal of Pharmacy Practice 17 (s1), pp.A41. (10.1211/096176709787640689)
- Jin, J. and Jones, A. T. 2009. The pH sensitive probe 5-(and-6)-carboxyl seminaphthorhodafluor is a substrate for the multidrug resistance-related protein MRP1. International Journal of Cancer 124 (1), pp.233-238. (10.1002/ijc.23892)
2008
- Hughes, M. L. , John, D. N. and Jones, A. T. 2008. The role of the Welsh language in community pharmacy service provision in Wales. London: Pharmacy Practice Research Trust.
- Jin, J. et al., 2008. Clustering of endocytic organelles in parental and drug-resistant myeloid leukaemia cell lines lacking centrosomally organised microtubule arrays. The International Journal of Biochemistry & Cell Biology 40 (10), pp.2240-2252. (10.1016/j.bioce1.2008.03.004)
- Jones, A. T. 2008. Gateways and tools for drug delivery: Endocytic pathways and the cellular dynamics of cell penetrating peptides. International Journal of Pharmaceutics 354 (1-2), pp.34-38. (10.1016/j.ijpharm.2007.10.046)
- Kosuge, M. et al., 2008. Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans. Bioconjugate Chemistry 19 (3), pp.656-664. (10.1021/bc700289w)
2007
- McGuigan, C. et al. 2007. Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus. Journal of Antimicrobial Chemotherapy 60 (6), pp.1316-1330. (10.1093/jac/dkm376)
- Fretz, M. M. et al., 2007. Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells. Biochemical Journal 403 (2), pp.335-342. (10.1042/BJ20061808)
- Futaki, S. et al., 2007. Arginine-rich peptides and their internalization mechanisms. Biochemical Society Transactions 35 (4), pp.784-787.
- Greco, F. et al., 2007. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. Journal of Controlled Release 117 (1), pp.28-39. (10.1016/j.jconrel.2006.10.012)
- Jones, A. T. 2007. Enclocytic pathways: gateways for intracellular drug delivery [Abstract]. Journal of Pharmacy and Pharmacology 59 (S1), pp.A72. 195. (10.1211/002235707781850023)
- Jones, A. T. 2007. Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptides. Journal of Cellular and Molecular Medicine 11 (4), pp.670-684. (10.1111/j.1582-4934.2007.00062.x)
- Maiti, K. K. et al., 2007. Guanidine-containing molecular transporters: Sorbitol-based transporters show high intracellular selectivity toward mitochondria. Angewandte Chemie International Edition 46 (31), pp.5880-5884. (10.1002/anie.200701346)
- Manunta, M. et al., 2007. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging. Journal of Drug Targeting 15 (1), pp.37-50. (10.1080/10611860601010330)
- Peeters, L. et al., 2007. Post-PEGylated lipoplexes are promising vehicles for gene delivery in RPE cells. Human Gene Therapy 18 (10), pp.1046-1047.
- Peeters, L. et al., 2007. Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells. Journal of Controlled Release 121 (3), pp.208-217. (10.1016/j.jconrel.2007.05.033)
2006
- Berna, M. et al., 2006. Novel monodisperse PEG-dendrons as new tools for targeted drug delivery: Synthesis, characterisation and cellular uptake. Biomacromolecules 7 (1), pp.146-153. (10.1021/bm050480s)
- Al-Taei, S. et al. 2006. Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors. Bioconjugate Chemistry 17 (1), pp.90-100. (10.1021/bc050274h)
- Fretz, M. M. et al. 2006. Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine. Journal of Controlled Release 116 (2), pp.247-254. (10.1016/j.jconrel.2006.07.009)
- Seib, F. P. , Jones, A. T. and Duncan, R. 2006. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer-doxorubicin. Journal of drug targeting 14 (6), pp.375-390. (10.1080/10611860600833955)
2005
- Hughes, M. L. , John, D. N. and Jones, A. T. 2005. Exploring the role of the Welsh language in community pharmacy: the professionals' views. International Journal of Pharmacy Practice 13 (s1), pp.R94. (10.1211/096176705777341217/pdf)
- Hughes, M. L. et al. 2005. Patients' views on use of the Welsh language in community pharmacy: an exploratory study. International Journal of Pharmacy Practice 13 (s1), pp.R93. (10.1211/096176705777341217/pdf)
- Simpson, J. C. and Jones, A. T. 2005. Early endocytic Rabs: functional prediction to functional characterization. In: McIlhinney, J. and Hooper, N. eds. Biochemical Society Symposia Volume 72: Lipids, Rafts and Traffic. Portland Press. , pp.99-108.
- Watson, P. D. , Jones, A. T. and Stephens, D. J. 2005. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Advanced Drug Delivery Reviews 57 (1), pp.43-61. (10.1016/j.addr.2004.05.003)
2004
- Nakase, I. et al., 2004. Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Molecular Therapy 10 (6), pp.1011-22. (10.1016/j.ymthe.2004.08.010)
- Simpson, J. C. et al., 2004. A role for the small GTPase Rab21 in the early endocytic pathway. Journal of cell science 117 (26), pp.6297-6311. (10.1242/jcs.01560)
2003
- Jones, A. T. , Gumbleton, M. and Duncan, R. 2003. Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems. Advanced Drug Delivery Reviews 55 (11), pp.1353-1367. (10.1016/j.addr.2003.07.002)
2001
- Jones, A. T. 2001. Intracellular drug delivery. Workshop teport from the 28th International Symposium on Controlled Release of Bioactive Materials, San Diego, 23-24 June 2001. Traffic 2 (12), pp.917-920. (10.1034/j.1600-0854.2001.21207.x)
1998
- Jones, A. T. et al. 1998. Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. Molecular Biology of the Cell 9 (2), pp.323-332. (10.1091/mbc.9.2.323)
- Jones, A. T. and Wessling-Resnick, M. 1998. Inhibition of in vitro endosomal vesicle fusion activity by aminoglycoside antibiotics. Journal of Biological Chemistry 273 (39), pp.25301-25309. (10.1074/jbc.273.39.25301)
1997
- Jones, A. T. and Clague, M. J. 1997. Regulation of early endosome fusion by phospholipase D activity. Biochemical and Biophysical Research Communications 236 (2), pp.285-288. (10.1006/bbrc.1997.6962)
- Gaffet, P. , Jones, A. T. and Clague, M. J. 1997. Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin. Journal of Biological Chemistry 272 (39), pp.24170-24175. (10.1074/jbc.272.39.24170)
Articles
- Newman, C. et al., 2026. Mechanism of uptake and toxicity of a BCMA antibody drug conjugate with a MMAF payload by nonantigen expressing cells. Cell Biology and Toxicology 42 86. (10.1007/s10565-026-10183-2)
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- Ziedan, N. I. et al., 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design (10.1111/cbdd.12936)
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- Gurney, L. R. I. et al., 2016. Use of cell penetrating peptides to treat inflammatory responses in human uterine cells. Reproductive Sciences 23 , pp.292A-292A. S-073. (10.1177/1933719116641257)
- Moody, P. R. et al. 2015. Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy 23 (12), pp.1888-1898. (10.1038/mt.2015.178)
- Lemmer, Y. et al., 2015. Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis. Journal of Controlled Release 211 , pp.94-104. (10.1016/j.jconrel.2015.06.005)
- Cilibrasi, V. et al. 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20), pp.2583-2585. (10.1016/j.tetlet.2015.03.132)
- Pereira, P. et al., 2015. siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate functionalized glycol chitosan nanogels. Molecular Pharmaceutics 12 (6), pp.1970-1979. 150416105321008. (10.1021/mp500785t)
- Wiggins, H. L. et al. 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93 (3), pp.332-342. (10.1016/j.bcp.2014.12.014)
- Webber, J. P. et al. 2015. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 (3), pp.290-302. (10.1038/onc.2013.560)
- Bahnsen, J. S. et al., 2015. Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. Pharmaceutical Research 32 (5), pp.1546-1556. (10.1007/s11095-014-1550-9)
- Sayers, E. J. et al. 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195 , pp.55-62. (10.1016/j.jconrel.2014.07.055)
- Cleal, K. et al. 2013. Endocytosis, intracellular traffic and fate of cell penetrating peptide based conjugates and nanoparticles. Current Pharmaceutical Design 19 (16), pp.2878-2894. (10.2174/13816128113199990297)
- Hamdy, R. et al., 2013. Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. Biorganic and Medicinal Chemistry Letters 23 (8), pp.2391-2394. (10.1016/j.bmcl.2013.02.029)
- Kothayer, H. et al., 2013. Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Biorganic and Medicinal Chemistry Letters 23 (24), pp.6886-6889. (10.1016/j.bmcl.2013.09.087)
- Mart, R. J. et al. 2013. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells. Molecular BioSystems 9 (11), pp.2597-2603. (10.1039/c3mb70246d)
- Al Soraj, M. et al., 2012. siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat. Journal of Controlled Release 161 (1), pp.132-141. (10.1016/j.jconrel.2012.03.015)
- Bailey, D. et al., 2012. An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases. Acta Crystallographica Section D: Biological Crystallography 68 (5), pp.541-552. (10.1107/S0907444912004817)
- Jones, A. T. and Sayers, E. J. 2012. Cell entry of cell penetrating peptides and tales of tails wagging dogs. Journal of Controlled Release 161 (2), pp.582-591. (10.1016/j.jconrel.2012.04.003)
- Watkins, C. L. et al., 2011. Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular Therapy 19 (12), pp.2124-2132. (10.1038/mt.2011.175)
- Vercauteren, D. et al., 2011. Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines. ACS Nano 5 (10), pp.7874-7884. (10.1021/nn2020858)
- Fricke, T. et al. 2011. Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins. Bioconjugate Chemistry 22 (9), pp.1763-1767. (10.1021/bc200338u)
- Vercauteren, D. et al., 2011. Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes. Biomaterials 32 (11), pp.3072-3084. (10.1016/j.biomaterials.2010.12.045)
- Al-Soraj, M. H. et al., 2010. siRNA versus pharmacological inhibition of endocytic pathways for studying cellular uptake of cell penetrating peptides and other drug delivery vectors. Drug Discovery Today 15 (23-24), pp.1103-1103. (10.1016/j.drudis.2010.09.411)
- Bruyere, H. , Westwell, A. and Jones, A. T. 2010. Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorganic & Medicinal Chemistry Letters 20 (7), pp.2200-2203. (10.1016/j.bmcl.2010.02.035)
- Fricke, T. et al. 2010. Click chemistry for the generation of cell permeable apoptotic peptides. Drug Discovery Today 15 (23-24), pp.1088-1088. (10.1016/j.drudis.2010.09.375)
- Gumbleton, M. and Jones, A. T. 2010. Cellular delivery of therapeutic macromolecules (CDTM) international Symposium 2010: lessons and progress from inter-disciplinary science. Drug Discovery Today 15 (23-24), pp.1079-180. (10.1016/j.drudis.2010.10.010)
- Sweeney, M. et al., 2010. Octaarginine mediated delivery of fluorescent cargo to human smooth muscle cells. Drug Discovery Today 15 (23-24), pp.1085-1085. (10.1016/j.drudis.2010.09.367)
- Vercauteren, D. et al., 2010. The use of inhibitors to study endocytic pathways of gene carriers: Optimization and pitfalls. Molecular Therapy 18 (3), pp.561-569. (10.1038/mt.2009.281)
- Watkins, C. L. et al. 2009. Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. Journal of Controlled Release 140 (3), pp.237-244. (10.1016/j.jconrel.2009.04.028)
- Watkins, C. L. et al. 2009. Low concentration thresholds of plasma membranes for rapid energy-independent translocation of a cell-penetrating peptide. Biochemical Journal 420 (2), pp.179-189. (10.1042/BJ20090042)
- Hughes, M. L. , John, D. N. and Jones, A. T. 2009. Information provided with dispensed medicines: What role does language choice play? A perspective from Wales [Abstract]. International Journal of Pharmacy Practice 17 (S2), pp.B44-B45. (10.1211/096176709789037128)
- Hughes, M. L. et al. 2009. Language issues in the community pharmacy: a perspective from Wales. International Journal of Pharmacy Practice 17 (3), pp.157-163. (10.1211/ijpp.17.03.0006)
- Hughes, M. L. , John, D. N. and Jones, A. T. 2009. Medicines use reviews and language choice. International Journal of Pharmacy Practice 17 (s1), pp.A41. (10.1211/096176709787640689)
- Jin, J. and Jones, A. T. 2009. The pH sensitive probe 5-(and-6)-carboxyl seminaphthorhodafluor is a substrate for the multidrug resistance-related protein MRP1. International Journal of Cancer 124 (1), pp.233-238. (10.1002/ijc.23892)
- Jin, J. et al., 2008. Clustering of endocytic organelles in parental and drug-resistant myeloid leukaemia cell lines lacking centrosomally organised microtubule arrays. The International Journal of Biochemistry & Cell Biology 40 (10), pp.2240-2252. (10.1016/j.bioce1.2008.03.004)
- Jones, A. T. 2008. Gateways and tools for drug delivery: Endocytic pathways and the cellular dynamics of cell penetrating peptides. International Journal of Pharmaceutics 354 (1-2), pp.34-38. (10.1016/j.ijpharm.2007.10.046)
- Kosuge, M. et al., 2008. Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans. Bioconjugate Chemistry 19 (3), pp.656-664. (10.1021/bc700289w)
- McGuigan, C. et al. 2007. Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus. Journal of Antimicrobial Chemotherapy 60 (6), pp.1316-1330. (10.1093/jac/dkm376)
- Fretz, M. M. et al., 2007. Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells. Biochemical Journal 403 (2), pp.335-342. (10.1042/BJ20061808)
- Futaki, S. et al., 2007. Arginine-rich peptides and their internalization mechanisms. Biochemical Society Transactions 35 (4), pp.784-787.
- Greco, F. et al., 2007. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. Journal of Controlled Release 117 (1), pp.28-39. (10.1016/j.jconrel.2006.10.012)
- Jones, A. T. 2007. Enclocytic pathways: gateways for intracellular drug delivery [Abstract]. Journal of Pharmacy and Pharmacology 59 (S1), pp.A72. 195. (10.1211/002235707781850023)
- Jones, A. T. 2007. Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptides. Journal of Cellular and Molecular Medicine 11 (4), pp.670-684. (10.1111/j.1582-4934.2007.00062.x)
- Maiti, K. K. et al., 2007. Guanidine-containing molecular transporters: Sorbitol-based transporters show high intracellular selectivity toward mitochondria. Angewandte Chemie International Edition 46 (31), pp.5880-5884. (10.1002/anie.200701346)
- Manunta, M. et al., 2007. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging. Journal of Drug Targeting 15 (1), pp.37-50. (10.1080/10611860601010330)
- Peeters, L. et al., 2007. Post-PEGylated lipoplexes are promising vehicles for gene delivery in RPE cells. Human Gene Therapy 18 (10), pp.1046-1047.
- Peeters, L. et al., 2007. Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells. Journal of Controlled Release 121 (3), pp.208-217. (10.1016/j.jconrel.2007.05.033)
- Berna, M. et al., 2006. Novel monodisperse PEG-dendrons as new tools for targeted drug delivery: Synthesis, characterisation and cellular uptake. Biomacromolecules 7 (1), pp.146-153. (10.1021/bm050480s)
- Al-Taei, S. et al. 2006. Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors. Bioconjugate Chemistry 17 (1), pp.90-100. (10.1021/bc050274h)
- Fretz, M. M. et al. 2006. Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine. Journal of Controlled Release 116 (2), pp.247-254. (10.1016/j.jconrel.2006.07.009)
- Seib, F. P. , Jones, A. T. and Duncan, R. 2006. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer-doxorubicin. Journal of drug targeting 14 (6), pp.375-390. (10.1080/10611860600833955)
- Hughes, M. L. , John, D. N. and Jones, A. T. 2005. Exploring the role of the Welsh language in community pharmacy: the professionals' views. International Journal of Pharmacy Practice 13 (s1), pp.R94. (10.1211/096176705777341217/pdf)
- Hughes, M. L. et al. 2005. Patients' views on use of the Welsh language in community pharmacy: an exploratory study. International Journal of Pharmacy Practice 13 (s1), pp.R93. (10.1211/096176705777341217/pdf)
- Watson, P. D. , Jones, A. T. and Stephens, D. J. 2005. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Advanced Drug Delivery Reviews 57 (1), pp.43-61. (10.1016/j.addr.2004.05.003)
- Nakase, I. et al., 2004. Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Molecular Therapy 10 (6), pp.1011-22. (10.1016/j.ymthe.2004.08.010)
- Simpson, J. C. et al., 2004. A role for the small GTPase Rab21 in the early endocytic pathway. Journal of cell science 117 (26), pp.6297-6311. (10.1242/jcs.01560)
- Jones, A. T. , Gumbleton, M. and Duncan, R. 2003. Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems. Advanced Drug Delivery Reviews 55 (11), pp.1353-1367. (10.1016/j.addr.2003.07.002)
- Jones, A. T. 2001. Intracellular drug delivery. Workshop teport from the 28th International Symposium on Controlled Release of Bioactive Materials, San Diego, 23-24 June 2001. Traffic 2 (12), pp.917-920. (10.1034/j.1600-0854.2001.21207.x)
- Jones, A. T. et al. 1998. Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. Molecular Biology of the Cell 9 (2), pp.323-332. (10.1091/mbc.9.2.323)
- Jones, A. T. and Wessling-Resnick, M. 1998. Inhibition of in vitro endosomal vesicle fusion activity by aminoglycoside antibiotics. Journal of Biological Chemistry 273 (39), pp.25301-25309. (10.1074/jbc.273.39.25301)
- Jones, A. T. and Clague, M. J. 1997. Regulation of early endosome fusion by phospholipase D activity. Biochemical and Biophysical Research Communications 236 (2), pp.285-288. (10.1006/bbrc.1997.6962)
- Gaffet, P. , Jones, A. T. and Clague, M. J. 1997. Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin. Journal of Biological Chemistry 272 (39), pp.24170-24175. (10.1074/jbc.272.39.24170)
Book sections
- Gurney, L. et al., 2022. Strategies for peptide-mediated cargo delivery to human smooth muscle cells. In: Langel, U. ed. Cell Penetrating Peptides. Vol. 2383, Methods in Molecular Biology book series Springer. , pp.459-471. (10.1007/978-1-0716-1752-6_29)
- Sayers, E. J. et al. 2022. Quantitative subcellular analysis of cyclic cell-penetrating peptide EJP18 in nonadherent cells. In: Cell Penetrating Peptides. Vol. 2383, Methods in Molecular Biology book series Springer. , pp.211-228. (10.1007/978-1-0716-1752-6_14)
- He, L. , Watson, P. D. and Jones, A. T. 2015. Visualizing actin architectures in cells incubated with cell-penetrating peptides. In: Langel, U. ed. Cell-Penetrating Peptides: Methods and Protocols. Vol. 1324, Methods in Molecular Biology Vol. 1324.Springer. , pp.247-259. (10.1007/978-1-4939-2806-4_16)
- Jones, A. T. 2010. Uptake and intracellular dynamics of proteins internalized by cell-penetrating peptides. In: Weissig, V. and D'Souza, G. G. M. eds. Organelle-Specific Pharmaceutical Nanotechnology. Hoboken, NJ.: John Wiley & Sons. , pp.263-288. (10.1002/9780470875780.ch15)
- Simpson, J. C. and Jones, A. T. 2005. Early endocytic Rabs: functional prediction to functional characterization. In: McIlhinney, J. and Hooper, N. eds. Biochemical Society Symposia Volume 72: Lipids, Rafts and Traffic. Portland Press. , pp.99-108.
Books
- Hughes, M. L. , John, D. N. and Jones, A. T. 2008. The role of the Welsh language in community pharmacy service provision in Wales. London: Pharmacy Practice Research Trust.
Conferences
- Wymant, J. et al. 2017. Poster 433: Receptor-antibody clustering induced endocytosis of HER2 has therapeutic potential in breast cancer. Presented at: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimising Immuno and Targeted Therapies From Cancer Biology to the Clinic Florence, Italy 24-27 June 2017.
Research
Latest research and engagement news from lab 1.14 and collaborators
April 2026: Delighted to see the fruits of our ADC work in collaboration with GSK bear fruit in a publication in Cell Biology and Toxicology: Mechanism of uptake and toxicity of a BCMA antibody drug conjugate with a MMAF payload by nonantigen expressing cells: doi: 10.1007/s10565-026-10183-2.
March 2026: See our paper published on St Davids Day on Trastuzumab decorated Nanoparticles in RSC Pharmaceutics
(1) Rapid plasma membrane reorganisation and endocytosis in HER2 breast cancer cells incubated with trastuzumab decorated polymer nanoparticles https://doi.org/10.1039/D5PM00168D
Teaching
- PH1121 Molecule to patient
- PH1122 The role of the pharmacist in professional practice
- PH2110 Clinical & professional pharmacy
- PH3110 Optimisation of pharmaceutical care
- PH3202 Research methodology
- PH4116 Pharmacy research or scholarship project
- PH4118 Pharmaceutical sciences, pharmacy practice and the patient
External
Lectures on Module PHT202 on MSc/Diploma in Clinical Research course
Biography
Career profile
Arwyn gained his PhD in protein crystallography at Birkbeck College, University of London and undertook postdoctoral positions investigating membrane traffic on the endocytic pathway at the University of Liverpool and Harvard University. In 2000 he was awarded a European Molecular Biology Organization fellowship to work at the European Molecular Biology Laboratory (EMBL), Heidelberg Germany and continued at the EMBL via an Alexander von Humboldt Foundation Scholarship.
In 2001 he was appointed as lecturer in the Cardiff School of Pharmacy and Pharmaceutical Sciences at Cardiff University where he is now Professor in Membrane Traffic and Drug Delivery. In 2018 he became the School of Pharmacy & Pharmaceutical Sciences Director of Research, Innovation and Engagement
Research projects in his lab fall under themes of cancer cell biology, endocytosis and drug delivery. A major scientific objective is linking fundamental endocytosis research to better understand the cellular delivery of drug delivery vectors including antibodies targeting plasma membrane receptors and cell penetrating peptides. He actively collaborates with a number of national and international groups including his recent strong involvement with CALIN, an €11.96 million, 4-year, Ireland-Wales funded programme bringing innovation, jobs and growth to Ireland and Wales, and COMPACT (2012-2017), an academic/industrial drug delivery consortium collaborating on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets.
He has a keen interest in the public understanding of science and in 2001 was awarded a BBC sponsored Diploma in Journalism from Bangor University. Since then he has been very active in public engagement with science at local and national levels and has organised several large Science exhibitions at the National Eisteddfod of Wales.
Professional memberships
- Editorial board of the Journal of Controlled Release, Membranes and Gwerddon
- Member of Cardiff Institute for Tissue Engineering and Repair (CITER).
- Member of the UK Biochemical Society and the American Society for Gene and Cell Therapy (ASGCB)
Committees and reviewing
Research Innovation and Engagement Committee
