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Emre Kopanoglu

Dr Emre Kopanoglu

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Available for postgraduate supervision

Teams and roles for Emre Kopanoglu

Overview

Research summary

Magnetic Resonance Imaging is a powerful imaging modality with high soft-tissue contrast, inherent safety due to the lack of ionizing radiation, and diagnostically sufficient signal-to-noise ratio. My research aims to improve diagnostic image quality as well as patient comfort and safety in MRI, and involves signal/image processing, computer modelling, and novel imaging hardware.

With many MRI scans lasting several minutes, patient motion is a severe problem. If uncorrected in real-time, many motion patterns change the imaged volume, and therefore make imaging data inconsistent and necessitate re-scanning the patient. On the one hand, at lower field strengths, real-time (prospective) motion correction techniques can adapt the imaging volume in real-time. However, lower field strengths mean lower signal-to-noise ratio and contrast-to-noise ratio, i.e. lower image quality. On the other hand, ultra-high field (UHF, >3T) MRI offers many benefits in terms of image quality and contrast. Unfortunately, UHF MRI suffers from undesired contrast variations across the image. While such variations can be compensated for using tailored radiofrequency pulses and multi-channel transmit (parallel-transmit) systems, designing such pulses takes from upwards of several seconds to a few minutes with many algorithms. Therefore, real-time motion correction has not been possible yet with such pulses. My current research focuses on designing parallel-transmit pulses in real-time.

Publication

2026

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

Articles

Conferences

Research

Current Research Interests 

My research focuses on Magnetic Resonance Imaging (MRI). More specifically, I am interested in safety and image quality in MRI.

 

Subject motion can cause subject heating to increase by more than 3-fold

An MRI scan causes tissue heating. This heating is minimal and precautions are taken to ensure it stays below strict safety limits. Because actual tissue heating cannot be quickly measured in vivo, computational modelling is utilized. To limit tissue heating, a proxy parameter, called the Specific Absorption Rate (SAR) is used. The distribution of SAR in space and the maximum value are called local SAR, and peak local SAR, respectively. 

When the subject moves during the scan, SAR may increase considerably. Our investigations showed more than 3-fold increase in peak local SAR due to subject motion. Example case: Figure 1. More detail: https://doi.org/10.1002/mrm.28276

 

Figure 1: Subject motion during the scan (20 mm rightward) caused peak local SAR to increase more than 3-fold. Results shown for a computational 8-channel parallel-transmit array tuned for 7T.

 

This is not a problem isolated to cases when the subject cannot remain still. The initial positioning of the subject also has a considerable effect on peak local SAR. When the subject is assumed to be at the centre but is positioned elsewhere, SAR may be underestimated by more than five-fold. Example case: Figure 2. More details: https://doi.org/10.1002/nbm.4876.

 

Figure 2: Even with perfect knowledge of the tissue content, a mismatch between assumed and actual subject position can cause substantial SAR underestimation. Results shown for a computational 8-channel parallel-transmit array tuned for 7T.

 

Preventing motion-related SAR increases require very large safety margins, which reduce imaging performance substantially, making MRI scans much longer. Alternatively, calculations can be adapted to subject motion in real-time. This relies on two conditions:

1- The change in how coil elements interact with tissues is known. This interaction leads to SAR.

2- Changes to the radiofrequency pulse can be performed in real-time.

 

We have demonstrated that Artificial Neural Networks (here, U-Nets) can be used to estimate how SAR changes reliably, in under 0.2 seconds of computation time. Example case: Figure 3. More detail: https://doi.org/10.1002/mrm.70363.

Figure 3: When the subject moves away from their initial position, the peak local SAR is underestimated by 31% (ground-truth: actual peak, initial: estimated using safety model located at centre). U-Nets can recover the actual peak local SAR with less than 2% error. Results shown for a realistic pulse that excites a homogeneous slice, using a computational 8-channel parallel-transmit array tuned for 7T.

 

Subject motion can cause excitation related data inconsistencies

Subject motion also affects the coil sensitivities inside the tissues. This leads to degradation of excitation homogeneity, creating artificial contrast variations on the image. These variations are unrelated to the tissue, and therefore, reduce diagnostic value. We have also used Artificial Neural Networks (here, cGANs) to estimate the changes in coil sensitivities, which enables improving excitation homogeneity as subject motion happens. Example case: Figure 4. More detail: https://doi.org/10.1002/mrm.29132.

 

Figure 4: The effect of motion on coil sensitivities is shown. The networks can reliably estimated the effect of motion on coil sensitivities. Results shown for a computational 8-channel parallel-transmit array tuned for 7T.

 

 

 

Shorter scans can yield high quality images when images are processed together

In clinical settings, multiple imaging protocols are used to image a subject. These imaging protocols are adjusted such that each image set is under the influence of a different contrast mechanism (Figure 5). These images provide complementary information, and therefore, maximize diagnostic value.

 

Figure 5: Images acquired under the influence of different contrast mechanisms provide complementary diagnostic information.

 

To reduce scan time, MRI protocols can be accelerated by acquiring less data. If certain conditions are satisfied, the effect of this data reduction can be compensated for via image processing. When we are processing acquired data, we can process different contrasts together. This allows information sharing, and improves image quality (Figure 7). However, this joint processing may also cause detrimental effects, such as the leakage of features that are unique to an image to the other images (leakage-of-features, Figure 6).

 

Figure 6: Processing images together (b) improves image quality compared to each image going through nonlinear reconstruction separately (a). However, this leads to leaking of features that are unique to one image to the other images (red arrows). Our proposed reconstruction method suppresses such leakage artefacts and yields artefact-free high-quality images (c). Please note that the image contrast was adjusted to maximize visibility of artefacts.

 

We proposed an image reconstruction algorithm that processes images both together and separately. Processing images together improves quality while processing images separately ensures that each image is faithful to its data. Therefore, the method yields high-quality images free of leakage-of-features (Figure 6). In-vivo images where the scan was accelerated by 87.5% show that high quality images can be acquired at 12.5% of the duration of a standard protocol (Figure 7).

 

Figure 7: Proton-density weighted, T1-weighted and T2-weighted images were processed together to reconstruct high quality images. All imaging protocols were 87.5% accelerated compared to their standard versions (acceleration factor R=8). The proposed method (SIMIT) showed the Lentiform Nucleus (pink arrows) and the frontal opercular cortex (yellow arrow) more clearly. SIMIT also depicted the gray-matter boundaries in the sulci more clearly in the T1-weighted images.

 

Blinded and random-order neuroradiologist scores highlight the superior performance of SIMIT in terms of diagnostic value (Figure 8).

 

Figure 8: Neuroradiologist scores highlight the improved image reconstruction performance of SIMIT. The neuroradiologist was blinded to method names and images were presented in randomized order.

 

Funding

 Wellcome Trust Discovery Award (2025 – 2033) –   ~ £4.9M

Democratising Neuroimaging Research with MRI

Derek Jones, Marco Palombo, Johnes Obungoloch, Emre Kopanoglu, Daniel Alexander, Andrew Webb, Mara Cercignani, Mark Griswold

Role: Co-I

Status: Active

EPSRC Doctoral Training Partnership – PhD Studentship (2024 – 2028) - £ 85,301

The Beat Goes On

Ian Driver, Kevin Murphy, Emre Kopanoglu

Role: Co-I

PhD Studentship; 2024 – 2028

Status: Active

Cardiff University – PhD Studentship (2024 – 2028) - £ 85,301

Make Yourself (MY-) Magnetic Resonance Imaging (MRI) Scanners: Designing Very Low Cost MRI Scanners to Make Medical Imaging Available in Underfunded Settings

Emre Kopanoglu, Derek K. Jones, Mara Cercignani

Role: PI

PhD Studentship; 2024 – 2028

Status: Active

SPF Research Grant (2023 – 2028) - £ 29,810,359

National facility for ultra-high field (11.7T) human MRI scanning

PI: Richard Bowtell. Co-I: Karin Shmueli, Shajan Gunamony, Jurgen Schneider, James Wild, Andrew Peet, Laura Parkes, Christopher Rodgers, Paul Glover, Ian Hall, Emre Kopanoglu, Zoe Kourtzi, Dorothee Auer, Harish Poptani, Penny Gowland, Shaihan Malik, Andrew Blamire, Damian Tyler, Andrew Bagshaw, Neal Bangerter, Geoff Parker, Derek Jones, Susan Francis, Paul Armitage, Jozien Goense, Peter Jezzard, Adam Berrington, Mara Cercignani, Ozlem Ipek, Steven Williams, Karen Mullinger, Rimona Weil, James Rowe, Daniel Alexander, Steven Sourbron, Peter Thelwall, Stuart Clare, Claudia Wheeler-Kingshott, Andrew Peters , Itamar Ronen

Role: Co-I

Status: Active

BBSRC Mid range equipment Initiative (2023) - £ 860,000

Upgrading our view of Growing Older: Mapping Brain Changes across the Lifespan with Ultra High Field Multi-Spectral MR

Mara Cercignani, John Evans, Derek Jones, Emre Kopanoglu, Michael Germuska, Daniel Gallichan, Kevin Murphy, Robert Turner

Role: Co-I

Status: Active

EPSRC Doctoral Training Partnership – PhD Studentship (2021 – 2025) - £ 81,528

New methods to quantify axonal magnetic properties and myelin integrity using MRI

Marco Palombo, Emre Kopanoglu, Robert Turner

Role: Co-I

PhD Studentship; 2023 – 2027

Status: Active

Cardiff University Neuroscience and Mental Health Innovation Institute – Future Leaders in Neuroscience Research Award (2023) - £ 1,410

Conference travel support

Status: Complete

Welsh Government Data Nation Accelerator Award (2022) - £ 8,836

Improving image quality and safety of ultra-high field magnetic resonance imaging using deep learning-based electromagnetic field prediction

Emre Kopanoglu, Alix Jean Deeley Plumley, Kevin Murphy

Role: PI

Status: Complete

EPSRC Doctoral Training Partnership – PhD Studentship (2021 – 2025) - £ 72,404

Using machine learning to ensure safety of patients who cannot remain still during magnetic resonance imaging       

Emre Kopanoglu, Kevin Murphy

Role: PI

PhD Studentship; 2021 – 2025 

Status: Active

Wellcome Trust Seed for Seed Award (2018) - £ 20,000

Magnetic resonance imaging of moving patients at ultra-high field: motion exacerbates the homogeneity artefacts due to wavelength effects

Emre Kopanoglu

Role: PI

Status: Complete

EPSRC Doctoral Training Partnership – PhD Studentship (2018 – 2022) - £ 71,101

Patient-motion tolerant functional Magnetic Resonance Imaging at the Ultra-high Field

Emre Kopanoglu, Kevin Murphy, Richard G. Wise.

Role: PI

PhD Studentship; 2018 – 2022

Status: Complete

EPSRC Doctoral Training Partnership – PhD Studentship (2018 – 2022) - £ 71,101

Magnetic Resonance Imaging of Moving Patients at Ultra-high Field: Real-time Motion Corrected Parallel-transmit Pulse Design

Emre Kopanoglu, Kevin Murphy

Role: PI

PhD Studentship; 2018 – 2022

Status: Complete

 

Research group

CUBRIC

 

 

Teaching

Qualifications

Fellow

Higher Education Academy, UK

2023

Scientific Teaching Fellow

Yale University, New Haven, CT, USA

2014

 

Modules taught

          PST 518 In-vivo Human Imaging

PS 3214: Neuroimaging in Health and Disease

PS 1018: Research Methods in Psychology

PS 3003: Occupational Placement

PST 510: Neuroimaging Research Project

PST 512: Introduction to Neuroimaging Methods

PST 513: Research Design and Analysis in Neuroimaging

PST 514: Introduction to Statistics and Matlab Programming

PST 515: Neuroimaging Research Proposal

 

Other Roles

Guest Lecturer, Cardiff University School of Engineering, 2022 – 2024

CUBRIC Health and Wellbeing contact, 2024 

Deputy Lead for Extenuating Circumstances, Cardiff University School of Psychology, 2022

Disability Officer, Cardiff University School of Psychology, 2022

Ethics Committee member, Cardiff University School of Psychology, 2022

MSc Programme Deputy Lead & Acting Co-Lead, Cardiff University School of Psychology, 2021 – 2022

Biography

Education

  • 2012: PhD in Electrical and Electronics  Engineering. Bilkent University, Ankara, Turkey. Novel Techniques Regarding Specific Absorption Rate and Field of View  Reduction in Magnetic Resonance Imaging
  • 2006: BSc in Electrical and Electronics  Engineering. Bilkent University, Ankara, Turkey.

Employment

  • 2017 – present: Lecturer / Senior Lecturer in Psychology. Cardiff University, Cardiff, UK.
  • 2015 – 2017: Senior Research Scientist. Aselsan Research Center, Ankara, Turkey.
  • 2012 – 2015: Post-Doctoral Associate. Radiology and Biomedical Imaging. Yale University, New Haven, CT, USA.
  • 2006 – 2012: Research and Teaching Assistant. Electrical and Electronics Engineering. Bilkent University, Ankara, Turkey.
  • 2006 – 2006: Undergraduate Teaching Assistant. Electrical and Electronics Engineering. Bilkent University, Ankara, Turkey.

Speaking engagements

Lecturer

ISMRT, Special ISMRM-ISMRT Forum, Annual Meeting of the ISMRM & ISMRT

ISMRM, Weekend Educational, Annual Meeting of the ISMRM & ISMRT

ESMRMB, Lectures on MR, Diffusion MRI and Spectroscopy

2024

 

2024

2023

Committees and reviewing

Committee Experience

Current

ISMRM Annual Meeting Programming Committee Member 2025 – present
ISMRM Sustainability Advisory Committee Member 2024 – present
ISMRM Turkish Chapter Board Member 2023 – present
ISMRM MRI Safety Committee Member 2020 – present
  Chair 2021 – 2025
ISMRM Web Development Committee Member 2021 – 2025

 

Organisation

ISMRM – RadAid International Masterclass Series on MRI Safety for Low- and Middle-Income Countries Organising Committee Chair 2026
ISMRT Future Leaders Program Workshop on MRI Safety in collaboration with ISMRM Safety Committee and Rad-Aid International Organizing Committee Member 2025
ESMRMB Lectures on MR, Diffusion MRI and Spectroscopy Organizing Committee Member 2023
ISMRM British & Irish Chapter Annual Meeting Organizing Committee Vice-Chair 2022

Supervisions

Current supervision

Past projects

Previous PhD students

  • Alix Plumley
  • Luke Watkins
  • Bleddyn Owen Woodward
  • Katherine Anna Blanter

Contact Details

Email [email protected]
Telephone +44 29225 10256
Campuses Cardiff University Brain Research Imaging Centre, Floor 1, Room 1.016, Maindy Road, Cardiff, CF24 4HQ

Specialisms

  • Simulation, modelling and programming of medical imaging
  • Magnetic Resonance Imaging
  • Patient safety
  • Signal and Image Processing
  • Compressed Sensing