![David McGonigle](https://profiles-cardiff.imgix.net/attachments/1128?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr David McGonigle
Lecturer
- McGonigleD@cardiff.ac.uk
- +44 29208 70353
- Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ
Overview
Research summary
Studying sensory processing means focusing on the rules and mechanisms that the brain uses to make sense of the world. I use the somatosensory system – the sense of touch – as a gateway to uncover some of the fundamental principles that govern neuronal communication in the human brain. I am particularly interested in the dynamic, plastic nature of sensory processing: how our perceptions are critically dependent on the waxing and waning of millisecond to millisecond changes in brain activity.
Using functional neuroimaging (fMRI, MEG and EEG) and behavioural techniques I focus on three main areas:
i) Where, when and how are tactile stimuli processed in the human brain?
ii) The principles underlying short-term changes in perception (adaptation) and longer-term changes (learning).
iii) How alterations in sensory processing contribute to brain conditions, such as Autism Spectrum Disorder (ASD).
I have also recently become interested in using brain stimulation to explore these questions, using a novel technique called trans-Cranial Direct Stimulation (tDCS). Finally, I have an active interest in the methods an reliability of non-invasive neuroimaging.
Teaching summary
Level 1 Psychology: PS1107 'Introduction to cognitive and biological psychology’ FSM
Level 3 Psychology PS3209 'Structural and functional neuroimaging’
MSc Neuroimaging: Methods and Applications
Publication
2019
- Puts, N., Edden, R. A., Muthukumaraswamy, S., Singh, K. and McGonigle, D. 2019. Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex. Neural Plasticity 2019, article number: 5464096. (10.1155/2019/5464096)
2018
- Puts, N. A. J. et al. 2018. GABA levels in left and right sensorimotor cortex correlate across individuals. Biomedicines 6(3), article number: 80. (10.3390/biomedicines6030080)
2016
- Hanley, C. J., Singh, K. D. and McGonigle, D. J. 2016. Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation. NeuroImage 140, pp. 20-32. (10.1016/j.neuroimage.2015.12.021)
- Soekadar, S. R., Herring, J. D. and McGonigle, D. 2016. Transcranial electric stimulation (tES) and Neurolmaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience. NeuroImage 140, pp. 1-3. (10.1016/j.neuroimage.2016.08.020)
2015
- Hanley, C. J., Tommerdahl, M. and McGonigle, D. 2015. Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS. Frontiers in Cellular Neuroscience 9, article number: 400. (10.3389/fncel.2015.00400)
2014
- Mullins, P. G., McGonigle, D., O'Gorman, R. L., Puts, N., Vidyasagar, R., Evans, C. J. and Edden, R. A. E. 2014. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. NeuroImage 86, pp. 43-52. (10.1016/j.neuroimage.2012.12.004)
2013
- Evans, C. J. et al. 2013. Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing. Journal of Magnetic Resonance Imaging 38(4), pp. 970-975. (10.1002/jmri.23923)
2012
- McGonigle, D. 2012. Test-retest reliability in fMRI: Or how I learned to stop worrying and love the variability. NeuroImage 62(2), pp. 1116-1120. (10.1016/j.neuroimage.2012.01.023)
2011
- Puts, N., Edden, R. A. E., Evans, C. J., McGlone, F. and McGonigle, D. 2011. Regionally specific human GABA concentration correlates with tactile discrimination thresholds. Journal of Neuroscience 31(46), pp. 16556-16560. (10.1523/JNEUROSCI.4489-11.2011)
- Wiestler, T., McGonigle, D. and Diedrichsen, J. 2011. Integration of sensory and motor representations of single fingers in the human cerebellum. Journal of Neurophysiology 105(6), pp. 3042-3053. (10.1152/jn.00106.2011)
2010
- Gradin, V. et al. 2010. Between- and within-scanner variability in the CaliBrain study n-back cognitive task. Psychiatry Research: Neuroimaging 184(2), pp. 86-95. (10.1016/j.pscychresns.2010.08.010)
- Hall, J. et al. 2010. A common neural system mediating two different forms of social judgement. Psychological Medicine 40(7), pp. 1183-1192. (10.1017/S0033291709991395)
- Evans, C. J., McGonigle, D. and Edden, R. A. E. 2010. Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex. Journal of Magnetic Resonance Imaging 31(1), pp. 204-209. (10.1002/jmri.21996)
- Zeman, A., Della Sala, S., Torrnes, L., Gountouna, V. E., McGonigle, D. and Logie, R. 2010. Loss of imagery phenomenology with intact visuo-spatial task performance: a case of 'blind imagination'. Neuropsychologia 48(1), pp. 145-155. (10.1016/j.neuropsychologia.2009.08.024)
- Gountouna, V. E. et al. 2010. Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. NeuroImage 49(1), pp. 552-560. (10.1016/j.neuroimage.2009.07.026)
2008
- Hall, J. et al. 2008. Overactivation of fear systems to neutral faces in schizophrenia. Biological Psychiatry 64(1), pp. 70-73. (10.1016/j.biopsych.2007.12.014)
- Erchova, I. and McGonigle, D. 2008. Rhythms of the brain: An examination of mixed mode oscillation approaches to the analysis of neurophysiological data. Chaos 18(1), article number: 15115. (10.1063/1.2900015)
2007
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2007. Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging study. Neuroimage 34(2), pp. 724-732. (10.1016/j.neuroimage.2006.07.033)
- Zhu, Z., Disbrow, E. A., Zumer, J. M., McGonigle, D. and Nagarajan, S. S. 2007. Spatiotemporal integration of tactile information in human somatosensory cortex. BMC Neuroscience 8(1), article number: 21. (10.1186/1471-2202-8-21)
2005
- Shehab, S., McGonigle, D., Hughes, D. I., Todd, A. J. and Redgrave, P. 2005. Anatomical evidence for an anticonvulsant relay in the rat ventromedial medulla. European Journal of Neuroscience 22(6), pp. 1431-1444. (10.1111/j.1460-9568.2005.04326.x)
- Smith, S. M. et al. 2005. Variability in fMRI: A re-examination of intersession Differences. Human Brain Mapping 24(3), pp. 248-257. (10.1002/hbm.20080)
2004
- Matharu, M. S., Cohen, A. S., McGonigle, D., Ward, N., Frackowiak, R. S. and Goadsby, P. J. 2004. Posterior Hypothalamic and Brainstem Activation in Hemicrania Continua. Headache: The Journal of Head and Face Pain 44(8), pp. 747-761. (10.1111/j.1526-4610.2004.04141.x)
2003
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2003. Gastric fundic distension activates fronto-limbic structures but not somatosensory cortex: A functional MRI (fMRI) study [Abstract]. Gastroenterology 124(4 (S1)), pp. A253. (10.1016/S0016-5085(03)81268-4)
2002
- McGonigle, D., Hanninen, R., Hari, R. and Salenius, S. 2002. Whose arm is it anyway? An fMRI case study od supernumerary phantom limb. Brain 125(6), pp. 1265-1274. (10.1093/brain/awf139)
2000
- McGonigle, D., Howseman, A. M., Athwal, B. S., Friston, K. J., Frackowiak, R. S. J. and Holmes, A. P. 2000. Variability in fMRI: an examination of intersession differences. NeuroImage 11(6), pp. 708-734. (10.1006/nimg.2000.0562)
1999
- May, A., Ashburner, J., Buchel, C., McGonigle, D., Friston, K. J., Frackowiak, R. S. J. and Goadsby, P. J. 1999. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nature Medicine 5(7), pp. 836-838. (10.1038/10561)
1996
- McGonigle, D., Maxwell, D. J., Shehab, S. A. S. and Kerr, R. 1996. Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat. Brain Research 742(1-2), pp. 1-9. (10.1016/S0006-8993(96)00942-0)
Articles
- Puts, N., Edden, R. A., Muthukumaraswamy, S., Singh, K. and McGonigle, D. 2019. Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex. Neural Plasticity 2019, article number: 5464096. (10.1155/2019/5464096)
- Puts, N. A. J. et al. 2018. GABA levels in left and right sensorimotor cortex correlate across individuals. Biomedicines 6(3), article number: 80. (10.3390/biomedicines6030080)
- Hanley, C. J., Singh, K. D. and McGonigle, D. J. 2016. Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation. NeuroImage 140, pp. 20-32. (10.1016/j.neuroimage.2015.12.021)
- Soekadar, S. R., Herring, J. D. and McGonigle, D. 2016. Transcranial electric stimulation (tES) and Neurolmaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience. NeuroImage 140, pp. 1-3. (10.1016/j.neuroimage.2016.08.020)
- Hanley, C. J., Tommerdahl, M. and McGonigle, D. 2015. Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS. Frontiers in Cellular Neuroscience 9, article number: 400. (10.3389/fncel.2015.00400)
- Mullins, P. G., McGonigle, D., O'Gorman, R. L., Puts, N., Vidyasagar, R., Evans, C. J. and Edden, R. A. E. 2014. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. NeuroImage 86, pp. 43-52. (10.1016/j.neuroimage.2012.12.004)
- Evans, C. J. et al. 2013. Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing. Journal of Magnetic Resonance Imaging 38(4), pp. 970-975. (10.1002/jmri.23923)
- McGonigle, D. 2012. Test-retest reliability in fMRI: Or how I learned to stop worrying and love the variability. NeuroImage 62(2), pp. 1116-1120. (10.1016/j.neuroimage.2012.01.023)
- Puts, N., Edden, R. A. E., Evans, C. J., McGlone, F. and McGonigle, D. 2011. Regionally specific human GABA concentration correlates with tactile discrimination thresholds. Journal of Neuroscience 31(46), pp. 16556-16560. (10.1523/JNEUROSCI.4489-11.2011)
- Wiestler, T., McGonigle, D. and Diedrichsen, J. 2011. Integration of sensory and motor representations of single fingers in the human cerebellum. Journal of Neurophysiology 105(6), pp. 3042-3053. (10.1152/jn.00106.2011)
- Gradin, V. et al. 2010. Between- and within-scanner variability in the CaliBrain study n-back cognitive task. Psychiatry Research: Neuroimaging 184(2), pp. 86-95. (10.1016/j.pscychresns.2010.08.010)
- Hall, J. et al. 2010. A common neural system mediating two different forms of social judgement. Psychological Medicine 40(7), pp. 1183-1192. (10.1017/S0033291709991395)
- Evans, C. J., McGonigle, D. and Edden, R. A. E. 2010. Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex. Journal of Magnetic Resonance Imaging 31(1), pp. 204-209. (10.1002/jmri.21996)
- Zeman, A., Della Sala, S., Torrnes, L., Gountouna, V. E., McGonigle, D. and Logie, R. 2010. Loss of imagery phenomenology with intact visuo-spatial task performance: a case of 'blind imagination'. Neuropsychologia 48(1), pp. 145-155. (10.1016/j.neuropsychologia.2009.08.024)
- Gountouna, V. E. et al. 2010. Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. NeuroImage 49(1), pp. 552-560. (10.1016/j.neuroimage.2009.07.026)
- Hall, J. et al. 2008. Overactivation of fear systems to neutral faces in schizophrenia. Biological Psychiatry 64(1), pp. 70-73. (10.1016/j.biopsych.2007.12.014)
- Erchova, I. and McGonigle, D. 2008. Rhythms of the brain: An examination of mixed mode oscillation approaches to the analysis of neurophysiological data. Chaos 18(1), article number: 15115. (10.1063/1.2900015)
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2007. Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging study. Neuroimage 34(2), pp. 724-732. (10.1016/j.neuroimage.2006.07.033)
- Zhu, Z., Disbrow, E. A., Zumer, J. M., McGonigle, D. and Nagarajan, S. S. 2007. Spatiotemporal integration of tactile information in human somatosensory cortex. BMC Neuroscience 8(1), article number: 21. (10.1186/1471-2202-8-21)
- Shehab, S., McGonigle, D., Hughes, D. I., Todd, A. J. and Redgrave, P. 2005. Anatomical evidence for an anticonvulsant relay in the rat ventromedial medulla. European Journal of Neuroscience 22(6), pp. 1431-1444. (10.1111/j.1460-9568.2005.04326.x)
- Smith, S. M. et al. 2005. Variability in fMRI: A re-examination of intersession Differences. Human Brain Mapping 24(3), pp. 248-257. (10.1002/hbm.20080)
- Matharu, M. S., Cohen, A. S., McGonigle, D., Ward, N., Frackowiak, R. S. and Goadsby, P. J. 2004. Posterior Hypothalamic and Brainstem Activation in Hemicrania Continua. Headache: The Journal of Head and Face Pain 44(8), pp. 747-761. (10.1111/j.1526-4610.2004.04141.x)
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2003. Gastric fundic distension activates fronto-limbic structures but not somatosensory cortex: A functional MRI (fMRI) study [Abstract]. Gastroenterology 124(4 (S1)), pp. A253. (10.1016/S0016-5085(03)81268-4)
- McGonigle, D., Hanninen, R., Hari, R. and Salenius, S. 2002. Whose arm is it anyway? An fMRI case study od supernumerary phantom limb. Brain 125(6), pp. 1265-1274. (10.1093/brain/awf139)
- McGonigle, D., Howseman, A. M., Athwal, B. S., Friston, K. J., Frackowiak, R. S. J. and Holmes, A. P. 2000. Variability in fMRI: an examination of intersession differences. NeuroImage 11(6), pp. 708-734. (10.1006/nimg.2000.0562)
- May, A., Ashburner, J., Buchel, C., McGonigle, D., Friston, K. J., Frackowiak, R. S. J. and Goadsby, P. J. 1999. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nature Medicine 5(7), pp. 836-838. (10.1038/10561)
- McGonigle, D., Maxwell, D. J., Shehab, S. A. S. and Kerr, R. 1996. Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat. Brain Research 742(1-2), pp. 1-9. (10.1016/S0006-8993(96)00942-0)
Research
Funding
Autism Speaks
Susanne and Bob Wright Trailblazer Award
(2012-2013; Costs $100,000)
NIHR Fellowship
A Pilot Neuroimaging Study of Chronic Regional Pain Syndrome (CRPS)
(2010-2015; Costs £154,345)
The Waterloo Foundation
Advanced Neuroimagingin BECTS
(2010-2012; Costs £113,039)
The Waterloo Foundation
Autistic Spectrum Disorder (ASD) and the neurobiology of sensory symptoms
(19/04/10-18/04/12; Costs £53,473)
TheWaterlooFoundation
Travel Grant to Attend IMFAR 2010
(2010; Costs £1550)
Royal Society Research Grant
An Investigation of the Spatiotemporal Integration of Tactile Information in Somatosensory Cortex using Magnetoencephalography (MEG)
(01/04/08-31/03/09; Costs £14,898)