![David McGonigle](https://profiles-cardiff.imgix.net/attachments/1128?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr David McGonigle
Lecturer
School of Biosciences
Overview
Research summary
Studying sensory processing means focusing on the rules and mechanisms that the brain uses to make sense of the world. I use the somatosensory system – the sense of touch – as a gateway to uncover some of the fundamental principles that govern neuronal communication in the human brain. I am particularly interested in the dynamic, plastic nature of sensory processing: how our perceptions are critically dependent on the waxing and waning of millisecond to millisecond changes in brain activity.
Using functional neuroimaging (fMRI, MEG and EEG) and behavioural techniques I focus on three main areas:
i) Where, when and how are tactile stimuli processed in the human brain?
ii) The principles underlying short-term changes in perception (adaptation) and longer-term changes (learning).
iii) How alterations in sensory processing contribute to brain conditions, such as Autism Spectrum Disorder (ASD).
I have also recently become interested in using brain stimulation to explore these questions, using a novel technique called trans-Cranial Direct Stimulation (tDCS). Finally, I have an active interest in the methods an reliability of non-invasive neuroimaging.
Teaching summary
Level 1 Psychology: PS1107 'Introduction to cognitive and biological psychology’ FSM
Level 3 Psychology PS3209 'Structural and functional neuroimaging’
MSc Neuroimaging: Methods and Applications
Publication
2019
- Puts, N., Edden, R. A., Muthukumaraswamy, S., Singh, K. and McGonigle, D. 2019. Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex. Neural Plasticity 2019, article number: 5464096. (10.1155/2019/5464096)
2018
- Puts, N. A. J. et al. 2018. GABA levels in left and right sensorimotor cortex correlate across individuals. Biomedicines 6(3), article number: 80. (10.3390/biomedicines6030080)
2016
- Hanley, C. J., Singh, K. D. and McGonigle, D. J. 2016. Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation. NeuroImage 140, pp. 20-32. (10.1016/j.neuroimage.2015.12.021)
- Soekadar, S. R., Herring, J. D. and McGonigle, D. 2016. Transcranial electric stimulation (tES) and Neurolmaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience. NeuroImage 140, pp. 1-3. (10.1016/j.neuroimage.2016.08.020)
2015
- Hanley, C. J., Tommerdahl, M. and McGonigle, D. 2015. Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS. Frontiers in Cellular Neuroscience 9, article number: 400. (10.3389/fncel.2015.00400)
2014
- Mullins, P. G., McGonigle, D., O'Gorman, R. L., Puts, N., Vidyasagar, R., Evans, C. J. and Edden, R. A. E. 2014. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. NeuroImage 86, pp. 43-52. (10.1016/j.neuroimage.2012.12.004)
2013
- Evans, C. J. et al. 2013. Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing. Journal of Magnetic Resonance Imaging 38(4), pp. 970-975. (10.1002/jmri.23923)
2012
- McGonigle, D. 2012. Test-retest reliability in fMRI: Or how I learned to stop worrying and love the variability. NeuroImage 62(2), pp. 1116-1120. (10.1016/j.neuroimage.2012.01.023)
2011
- Puts, N., Edden, R. A. E., Evans, C. J., McGlone, F. and McGonigle, D. 2011. Regionally specific human GABA concentration correlates with tactile discrimination thresholds. Journal of Neuroscience 31(46), pp. 16556-16560. (10.1523/JNEUROSCI.4489-11.2011)
- Wiestler, T., McGonigle, D. and Diedrichsen, J. 2011. Integration of sensory and motor representations of single fingers in the human cerebellum. Journal of Neurophysiology 105(6), pp. 3042-3053. (10.1152/jn.00106.2011)
2010
- Gradin, V. et al. 2010. Between- and within-scanner variability in the CaliBrain study n-back cognitive task. Psychiatry Research: Neuroimaging 184(2), pp. 86-95. (10.1016/j.pscychresns.2010.08.010)
- Hall, J. et al. 2010. A common neural system mediating two different forms of social judgement. Psychological Medicine 40(7), pp. 1183-1192. (10.1017/S0033291709991395)
- Evans, C. J., McGonigle, D. and Edden, R. A. E. 2010. Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex. Journal of Magnetic Resonance Imaging 31(1), pp. 204-209. (10.1002/jmri.21996)
- Zeman, A., Della Sala, S., Torrnes, L., Gountouna, V. E., McGonigle, D. and Logie, R. 2010. Loss of imagery phenomenology with intact visuo-spatial task performance: a case of 'blind imagination'. Neuropsychologia 48(1), pp. 145-155. (10.1016/j.neuropsychologia.2009.08.024)
- Gountouna, V. E. et al. 2010. Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. NeuroImage 49(1), pp. 552-560. (10.1016/j.neuroimage.2009.07.026)
2008
- Hall, J. et al. 2008. Overactivation of fear systems to neutral faces in schizophrenia. Biological Psychiatry 64(1), pp. 70-73. (10.1016/j.biopsych.2007.12.014)
- Erchova, I. and McGonigle, D. 2008. Rhythms of the brain: An examination of mixed mode oscillation approaches to the analysis of neurophysiological data. Chaos 18(1), article number: 15115. (10.1063/1.2900015)
2007
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2007. Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging study. Neuroimage 34(2), pp. 724-732. (10.1016/j.neuroimage.2006.07.033)
- Zhu, Z., Disbrow, E. A., Zumer, J. M., McGonigle, D. and Nagarajan, S. S. 2007. Spatiotemporal integration of tactile information in human somatosensory cortex. BMC Neuroscience 8(1), article number: 21. (10.1186/1471-2202-8-21)
2005
- Shehab, S., McGonigle, D., Hughes, D. I., Todd, A. J. and Redgrave, P. 2005. Anatomical evidence for an anticonvulsant relay in the rat ventromedial medulla. European Journal of Neuroscience 22(6), pp. 1431-1444. (10.1111/j.1460-9568.2005.04326.x)
- Smith, S. M. et al. 2005. Variability in fMRI: A re-examination of intersession Differences. Human Brain Mapping 24(3), pp. 248-257. (10.1002/hbm.20080)
2004
- Matharu, M. S., Cohen, A. S., McGonigle, D., Ward, N., Frackowiak, R. S. and Goadsby, P. J. 2004. Posterior Hypothalamic and Brainstem Activation in Hemicrania Continua. Headache: The Journal of Head and Face Pain 44(8), pp. 747-761. (10.1111/j.1526-4610.2004.04141.x)
2003
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2003. Gastric fundic distension activates fronto-limbic structures but not somatosensory cortex: A functional MRI (fMRI) study [Abstract]. Gastroenterology 124(4 (S1)), pp. A253. (10.1016/S0016-5085(03)81268-4)
2002
- McGonigle, D., Hanninen, R., Hari, R. and Salenius, S. 2002. Whose arm is it anyway? An fMRI case study od supernumerary phantom limb. Brain 125(6), pp. 1265-1274. (10.1093/brain/awf139)
2000
- McGonigle, D., Howseman, A. M., Athwal, B. S., Friston, K. J., Frackowiak, R. S. J. and Holmes, A. P. 2000. Variability in fMRI: an examination of intersession differences. NeuroImage 11(6), pp. 708-734. (10.1006/nimg.2000.0562)
1999
- May, A., Ashburner, J., Buchel, C., McGonigle, D., Friston, K. J., Frackowiak, R. S. J. and Goadsby, P. J. 1999. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nature Medicine 5(7), pp. 836-838. (10.1038/10561)
1996
- McGonigle, D., Maxwell, D. J., Shehab, S. A. S. and Kerr, R. 1996. Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat. Brain Research 742(1-2), pp. 1-9. (10.1016/S0006-8993(96)00942-0)
Articles
- Puts, N., Edden, R. A., Muthukumaraswamy, S., Singh, K. and McGonigle, D. 2019. Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex. Neural Plasticity 2019, article number: 5464096. (10.1155/2019/5464096)
- Puts, N. A. J. et al. 2018. GABA levels in left and right sensorimotor cortex correlate across individuals. Biomedicines 6(3), article number: 80. (10.3390/biomedicines6030080)
- Hanley, C. J., Singh, K. D. and McGonigle, D. J. 2016. Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation. NeuroImage 140, pp. 20-32. (10.1016/j.neuroimage.2015.12.021)
- Soekadar, S. R., Herring, J. D. and McGonigle, D. 2016. Transcranial electric stimulation (tES) and Neurolmaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience. NeuroImage 140, pp. 1-3. (10.1016/j.neuroimage.2016.08.020)
- Hanley, C. J., Tommerdahl, M. and McGonigle, D. 2015. Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS. Frontiers in Cellular Neuroscience 9, article number: 400. (10.3389/fncel.2015.00400)
- Mullins, P. G., McGonigle, D., O'Gorman, R. L., Puts, N., Vidyasagar, R., Evans, C. J. and Edden, R. A. E. 2014. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. NeuroImage 86, pp. 43-52. (10.1016/j.neuroimage.2012.12.004)
- Evans, C. J. et al. 2013. Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing. Journal of Magnetic Resonance Imaging 38(4), pp. 970-975. (10.1002/jmri.23923)
- McGonigle, D. 2012. Test-retest reliability in fMRI: Or how I learned to stop worrying and love the variability. NeuroImage 62(2), pp. 1116-1120. (10.1016/j.neuroimage.2012.01.023)
- Puts, N., Edden, R. A. E., Evans, C. J., McGlone, F. and McGonigle, D. 2011. Regionally specific human GABA concentration correlates with tactile discrimination thresholds. Journal of Neuroscience 31(46), pp. 16556-16560. (10.1523/JNEUROSCI.4489-11.2011)
- Wiestler, T., McGonigle, D. and Diedrichsen, J. 2011. Integration of sensory and motor representations of single fingers in the human cerebellum. Journal of Neurophysiology 105(6), pp. 3042-3053. (10.1152/jn.00106.2011)
- Gradin, V. et al. 2010. Between- and within-scanner variability in the CaliBrain study n-back cognitive task. Psychiatry Research: Neuroimaging 184(2), pp. 86-95. (10.1016/j.pscychresns.2010.08.010)
- Hall, J. et al. 2010. A common neural system mediating two different forms of social judgement. Psychological Medicine 40(7), pp. 1183-1192. (10.1017/S0033291709991395)
- Evans, C. J., McGonigle, D. and Edden, R. A. E. 2010. Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex. Journal of Magnetic Resonance Imaging 31(1), pp. 204-209. (10.1002/jmri.21996)
- Zeman, A., Della Sala, S., Torrnes, L., Gountouna, V. E., McGonigle, D. and Logie, R. 2010. Loss of imagery phenomenology with intact visuo-spatial task performance: a case of 'blind imagination'. Neuropsychologia 48(1), pp. 145-155. (10.1016/j.neuropsychologia.2009.08.024)
- Gountouna, V. E. et al. 2010. Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. NeuroImage 49(1), pp. 552-560. (10.1016/j.neuroimage.2009.07.026)
- Hall, J. et al. 2008. Overactivation of fear systems to neutral faces in schizophrenia. Biological Psychiatry 64(1), pp. 70-73. (10.1016/j.biopsych.2007.12.014)
- Erchova, I. and McGonigle, D. 2008. Rhythms of the brain: An examination of mixed mode oscillation approaches to the analysis of neurophysiological data. Chaos 18(1), article number: 15115. (10.1063/1.2900015)
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2007. Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging study. Neuroimage 34(2), pp. 724-732. (10.1016/j.neuroimage.2006.07.033)
- Zhu, Z., Disbrow, E. A., Zumer, J. M., McGonigle, D. and Nagarajan, S. S. 2007. Spatiotemporal integration of tactile information in human somatosensory cortex. BMC Neuroscience 8(1), article number: 21. (10.1186/1471-2202-8-21)
- Shehab, S., McGonigle, D., Hughes, D. I., Todd, A. J. and Redgrave, P. 2005. Anatomical evidence for an anticonvulsant relay in the rat ventromedial medulla. European Journal of Neuroscience 22(6), pp. 1431-1444. (10.1111/j.1460-9568.2005.04326.x)
- Smith, S. M. et al. 2005. Variability in fMRI: A re-examination of intersession Differences. Human Brain Mapping 24(3), pp. 248-257. (10.1002/hbm.20080)
- Matharu, M. S., Cohen, A. S., McGonigle, D., Ward, N., Frackowiak, R. S. and Goadsby, P. J. 2004. Posterior Hypothalamic and Brainstem Activation in Hemicrania Continua. Headache: The Journal of Head and Face Pain 44(8), pp. 747-761. (10.1111/j.1526-4610.2004.04141.x)
- Ladabaum, U., Roberts, T. P. and McGonigle, D. 2003. Gastric fundic distension activates fronto-limbic structures but not somatosensory cortex: A functional MRI (fMRI) study [Abstract]. Gastroenterology 124(4 (S1)), pp. A253. (10.1016/S0016-5085(03)81268-4)
- McGonigle, D., Hanninen, R., Hari, R. and Salenius, S. 2002. Whose arm is it anyway? An fMRI case study od supernumerary phantom limb. Brain 125(6), pp. 1265-1274. (10.1093/brain/awf139)
- McGonigle, D., Howseman, A. M., Athwal, B. S., Friston, K. J., Frackowiak, R. S. J. and Holmes, A. P. 2000. Variability in fMRI: an examination of intersession differences. NeuroImage 11(6), pp. 708-734. (10.1006/nimg.2000.0562)
- May, A., Ashburner, J., Buchel, C., McGonigle, D., Friston, K. J., Frackowiak, R. S. J. and Goadsby, P. J. 1999. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nature Medicine 5(7), pp. 836-838. (10.1038/10561)
- McGonigle, D., Maxwell, D. J., Shehab, S. A. S. and Kerr, R. 1996. Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat. Brain Research 742(1-2), pp. 1-9. (10.1016/S0006-8993(96)00942-0)
Research
Funding
Autism Speaks
Susanne and Bob Wright Trailblazer Award
(2012-2013; Costs $100,000)
NIHR Fellowship
A Pilot Neuroimaging Study of Chronic Regional Pain Syndrome (CRPS)
(2010-2015; Costs £154,345)
The Waterloo Foundation
Advanced Neuroimagingin BECTS
(2010-2012; Costs £113,039)
The Waterloo Foundation
Autistic Spectrum Disorder (ASD) and the neurobiology of sensory symptoms
(19/04/10-18/04/12; Costs £53,473)
TheWaterlooFoundation
Travel Grant to Attend IMFAR 2010
(2010; Costs £1550)
Royal Society Research Grant
An Investigation of the Spatiotemporal Integration of Tactile Information in Somatosensory Cortex using Magnetoencephalography (MEG)
(01/04/08-31/03/09; Costs £14,898)
Contact Details
McGonigleD@cardiff.ac.uk
+44 29208 70353
Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ
+44 29208 70353
Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ