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Georgina Menzies

Dr Georgina Menzies


School of Biosciences

+44 29206 88463
Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Available for postgraduate supervision


Structural and functional investigations using molecular modelling and molecular simulations

My current role is a lecturer with a research portfolio in understanding DNA-repair and disease modifying coding mutations. Prior to this appointment I held a Ser Cyrmu II Fellowship in the Dementia Research Institute at Cardiff. 

My research focuses on using structural modelling and protein dynamics (via simulation) to understand the impact of coding changes or specific structural features on disease. I am interested in the impact of DNA structure and mutations in the repair machinery on DNA repair rates and how this affects age at onset or dementia risk as well as development or progression of mutations in cancer.

I also work on many collaborative projects. For example, protein variants, such as those in PLCG2, TREM2 and ATP8B4. The long-term goal here is to characterise coding mutations in neurodegenerative disease. This will be achieved by creating protein models which contain the amino acid changes of novel genetic variants and using these to make functional predictions. Outcomes from this research will provide new insights on the impact of mutations associated with neurodegenerative diseases and accelerate the path towards translation. 

Most of my research involves techniques including molecular dynamics, coarse grain modelling and mathematical modelling. I use these models resulting from these studies to elucidate information as to how structural changes may be affecting the function of the biological system. A large part of this is data analysis. All model systems produce 'large data' sets and I utilise multivariate analysis tools to decipher patterns and correlate this back to biological answers. I collaborate with a number of other researchers and research groups to provide structural and functional information for their biological structure of interest. This ranges from drugs to anti-bodies and proteins.

I am involved in the Alzheimer's Research U.K. network in South Wales, and helped drive the ECR steering committee for the UKDRI cross-centre theme on DNA repair and neurodegeneration into existence.

I have always been interested in how structure relates to function and am always interested in studying something new. Please contact me with collaboration ideas. 


















  • BIT107 Module Lead
  • BIT106 Module Lead
  • Big Data Biology Deputy Course Lead
  • Lecturer - BI3255 - Synthetic Biology and Protein Engineering.
  • Lecturer - CM2203 - Informatics.
  • Lecturer and Supervisor - BI3008 - Advanced Research Techniques
  • Supervisor - BI4001 - Advanced Reserach Project (Integrated Masters)
  • Supervisor - BI3001 - Rearch Project (BSc)
  • Contributor - BI1001 - Skills for Science 



I gained my BSc(Hons) in Forensic Science from the Uniersity of Glamorgan, studied for a MSc in Molecular Modelling from Cardiff University and for my PhD focused on the structure of DNA in cancer hotspot sites at Swansea University under the supervision of Prof Paul Lewis. 

After a Ser Cymru II fellowship to study the functional outcomes of dementia genetics, I took up a lectureship at the School of Biosciences in Cardiff University.

My main research interests involve studying DNA repair pathways and in particular the protein and DNA strcutral interactions using molecular modelling techniques. I also collaborates with a number of other researchers and reserach groups to provide strucural and functional information for their biological strucutre of interest. This ranges from drugs to anti-boides and proteins. Most of my reserach involves modelling techniques including molecular dynamics, coarse grain and mathematical modelling.

Honours and awards

Welsh Crucible 2021

CLIRSPC attendance and travel bursary for SPEC2016

SDMF seed corn grant 2015 (£2,500)

UKEMS conference attendance bursary for EEMS 2014 and UKEMS 2013

EuroTox bursary for conference fees 2014

Professional memberships

  • Royal Society of Chemistry (RSC)
  • United Kingdom Environmental Mutagenesis Society (UKEMS)
  • Molecular Graphics and Modelling Society (MGMS)
  • The International Society for Clinical Spectroscopy (CLIRSPEC)

Network Memberships and committees 

  • ARUK South Wales ECR REP
  • ARUK ECR working group invited member
  • DNA Repair in Neurodegeneration, member and ECR committee lead
  • School of Biosciences  EDI committee member

Academic positions

April 2020 -
Lecturer Cardiff University School of Biosciences
June 2018 -
April 2020
Ser Cymru II Fellow Dementia Research Institute at Cardiff University
December 2016 - June 2018 Post-Doctoral Research Associate Cardiff University. MRC Centre for Neuropsychiatric Genetics & Genomics
July 2014 - December 2016 Post-Doctoral Research Assistant Swansea University - Tailored OligoG Project - funded by Norwegian Research Council
January 2015 -
January 2016

MutAIT project (

June 2012 -
June 2014
Research Assistant

Swansea University - Celtic Alliance for NanoHealth Project - funded by INTERREG IVA Ireland Wales Program

Committees and reviewing

  • ECR Representative (ARUK Network & DNA repair theme, Dementia Research Institute)
  • Athena Swan Community Committee
  • Dementia Research Institute executive committee member 2018 - present
  • Alzheimer’s Research UK (ARUK) South Wales Network ECR Rep.
  • Organiser - ARUK Public engagement events - 2019, 2021, 2023
  • Co-organiser - ARUK open day 2018, Hadyn Ellis Building

Grant Reviewer

  • Alzheimer's Society

Journal Reviewer

  • Structure
  • Translational Neuroscience

Journal Editor

  • Frontiers in Dementia



I am interested in supervising students in the areas of;

  • Development of Molecular Modelling platforms for DNA strucural analysis
  • Molecular Dynamics simulations of CRISPR systems
  • Molecular Dyanamics simulations of protein mutations
  • Simulations and analysis of DNA strucutre in relation to repair pathways

Current supervision or co-supervision:

  • Antione Mangin; Optimizing Cas9 delivery as a gene editing treatment in expanded CAG/CTG repeats. - PhD, second supervisor 
  • James Davies; carcinogens and their interactions with DNA/repair machineary. - PhD, primary supervisor
  • Rebekah Cooke; Using antibodies as templates to develop small molecule anti- complement drugs to deliver to Alzheimer’s brain. - PhD, second supervisor
  • Edward Birt; A combination of in silico and in vitro studies to understand the regulation of microglia by the novel Alzheimer’s disease risk gene ATP8B4. - PhD, second supervisor

Past projects

  • Elisa Salis - PhD awarded 2022
  • James Davies - Integrated Masters - 2021/2



ARUK Inspire Fund - Brain health £4,150 PI


ARUK Network Event at the Swalec Stadium


ARUK South Wales Network Cheese and Wine evening. Organiser


ARUK South Wales Network Afternoon Tea and Talks. Organiser


Pint of Science. Speaker


DRI Opening Event. Soap Box Science. Speaker


ARUK South Wales Network Afternoon Open Day. Co-Organiser