Dr Ryan Moseley

Professor in Tissue Repair

: MoseleyR@cardiff.ac.uk
: +44 29225 10649
: University Dental Hospital, Room Room 413, 4th Floor, Heath Park, Cardiff, CF14 4XY

: Media commentator
: Available for postgraduate supervision

Research Group

My research specialises in the mechanisms underlying cellular wound healing responses in oral (bone, oral mucosa, dental pulp, gingiva) and dermal (normal skin, chronic skin wounds, fibrotic skin) tissues during health and disease. By understanding these mechanisms, my Research Group develops novel cellular, biomaterial, pharmaceutical and other strategies to promote normal tissue repair and improved wound management in these patients. Such research activities include the translational development of a novel class of natural and semi-synthetic compounds, termed epoxy-tiglianes, for the treatment of non-healing chronic skin wounds and dermal scarring/fibrosis, with industrial and academic collaborators based in Australia:

https://www.cardiff.ac.uk/research/impact-and-innovation/research-impact/rainforest-helps-treat-patients-chronic-wounds

I have successfully managed numerous projects in these research areas, supported by non-commercial and commercial funding sources worldwide (>£3.4M to date). These include the MRC, NHMRC (Australia), Wellcome Trust, Dunhill Medical Trust, Life Sciences Research Network Wales (Sêr Cymru), NISCHR, Knowledge Economy Skills Scholarships (KESS2) East Wales, Malaysian Government, Iraqi Government; and Kingdom of Saudi Arabia Government, in addition to industrial partners including Convatec Wound Care Ltd., Johnson and Johnson Wound Management Ltd. (now Systagenix Wound Management Ltd.), Peplin Inc. (now owned by LEO Pharma A/S), QBiotics Group, Phillips Research and Cultech Ltd.

My research has culminated in numerous published peer-reviewed papers, filed patents with industrial partners in the dermal wound healing sector; and many local, national and international conference prizes for staff and students under my supervision.

2023

Moses, R. L., Prescott, T. A., Mas-Claret, E., Steadman, R., Moseley, R. and Sloan, A. J. 2023. Evidence for natural products as alternative wound-healing therapies. Biomolecules 13(3), article number: 444. (10.3390/biom13030444)

2018

Yusop, N., Battersby, P., Alraies, A., Sloan, A. J., Moseley, R. and Waddington, R. J. 2018. Isolation and characterisation of mesenchymal stem cells from rat bone marrow and the endosteal niche: A comparative study. Stem Cells International, article number: 6869128. (10.1155/2018/6869128)

2017

Rokad, F., Moseley, R., Hardy, R. S., Chukkapalli, S., Crean, S., Kesavalu, L. and Singhrao, S. K. 2017. Cerebral oxidative stress and microvasculature defects in TNF-a expressing transgenic and Porphyromonas gingivalis-infected ApoE-/- mice. Journal of Alzheimer's Disease 60(2), pp. 359-369. (10.3233/JAD-170304)
Dally, J. et al. 2017. Hepatocyte growth factor mediates enhanced wound healing responses and resistance to transforming growth factor-β1-driven myofibroblast differentiation in oral mucosal fibroblasts. International Journal of Molecular Sciences 18, article number: 1843. (10.3390/ijms18091843)
Alraies, A., Alaidaroos, N. Y. A., Waddington, R. J., Moseley, R. and Sloan, A. J. 2017. Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities. BMC Cell Biology 18, article number: 12. (10.1186/s12860-017-0128-x)

2016

Waddington, R. J., Jones, Q. and Moseley, R. 2016. Assessing the potential of mesenchymal stem cells in craniofacial bone repair and regeneration. In: Waddington, R. J. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. Wiley Blackwell, pp. 69-95., (10.1002/9781119282181.ch4)

2014

McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
Antonarakis, G. S., Moseley, R. and Waddington, R. J. 2014. Differential influence of fluoride concentration on the synthesis of bone matrix glycoproteins within mineralizing bone cellsin vitro. Acta Odontologica Scandinavica 72(8), pp. 1066-1069. (10.3109/00016357.2014.882982)

2013

Daw, A. E. et al. 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28(1), pp. 144-160. (10.1177/0885328212441495)
Azzopardi, E. A., Camilleri, L., Moseley, R., Thomas, D. W. and Ferguson, E. L. 2013. Statistical characterization of succinoylated dextrin degradation behavior in human α-amylase. Journal of Carbohydrate Chemistry 32(7), pp. 438-449. (10.1080/07328303.2013.831434)

2011

Ferguson, E. L., Roberts, J. L., Moseley, R., Griffiths, P. C. and Thomas, D. W. 2011. Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments. International Journal of Pharmaceutics 420(1), pp. 84-92. (10.1016/j.ijpharm.2011.08.031)
Waddington, R. J., Alraies, A., Colombo, J. S., Sloan, A. J., Okazaki, J. and Moseley, R. 2011. Characterization of oxidative stress status during diabetic bone healing. Cells Tissues Organs 194(2-4), pp. 307-312. (10.1159/000324251)
Hardwicke, J., Hart, J., Bell, A., Duncan, R., Thomas, D. W. and Moseley, R. 2011. The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse. Journal of Controlled Release 152(3), pp. 411-417. (10.1016/j.jconrel.2011.03.016)

2010

Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
Pukstad, B. . S. et al. 2010. Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of Dermatological Science 59(2), pp. 115-122. (10.1016/j.jdermsci.2010.05.003)
Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
Hardwicke, J., Song, B., Moseley, R. and Thomas, D. W. 2010. Investigation of the potential of polymer therapeutics in corneal re-epithelialisation. British Journal of Ophthalmology 94(12), pp. 1566-1570. (10.1136/bjo.2009.177295)

2009

Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)

2008

Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
Roberts, H. C., Moseley, R., Sloan, A. J., Youde, S. J. and Waddington, R. J. 2008. Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: Consequences for bone repair during periodontal disease. European Journal of Oral Sciences 116(3), pp. 207-216. (10.1111/j.1600-0722.2008.00535.x)
Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
Nagassa, M. E., Daw, A. E., Rowe, W. G., Carley, A. F., Thomas, D. W. and Moseley, R. 2008. Optimisation of the hydrogen peroxide pre-treatment of titanium: surface characterisation and protein adsorption. Clinical Oral Implants Research 19(12), pp. 1317-1326. (10.1111/j.1600-0501.2008.01611.x)

2004

Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
Waddington, R. J., Moseley, R., Smith, A. J., Sloan, A. J. and Embery, G. 2004. Fluoride-induced changes to proteoglycan structure synthesised within the dentine-pulp complex in vitro. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1689(2), pp. 142-151. (10.1016/j.bbadis.2004.03.003)
Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)

2003

Moseley, R., Waddington, R. J., Sloan, A. J., Smith, A. J., Hall, R. and Embery, G. 2003. The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model. Calcified Tissue International 73(5), pp. 470-475. (10.1007/s00223-003-0022-8)
Moseley, R., Sloan, A. J., Waddington, R. J., Smith, A. J., Hall, R. and Embery, G. 2003. The influence of fluoride on the cellular morphology and synthetic activity of the rat dentine-pulp complex in vitro. Archives of Oral Biology 48(1), pp. 39-46. (10.1016/S0003-9969(02)00160-7)
Moseley, R., Walker, M., Waddington, R. J. and Chen, W. 2003. Comparison of the antioxidant properties of wound dressing materials-carboxymethylcellulose, hyaluronan benzyl ester and hyaluronan, towards polymorphonuclear leukocyte-derived reactive oxygen species. Biomaterials 24(9), pp. 1549-1557. (10.1016/S0142-9612(02)00540-9)

2002

Moseley, R., Leaver, M., Waddington, R. J., Walker, M., Parsons, D., Chen, W. and Embery, G. 2002. Comparison of the antioxidant properties of HYAFF-11p75, AQUACEL and hyaluronan towards reactive oxygen species in vitro. Biomaterials 23(10), pp. 2255-2264. (10.1016/S0142-9612(01)00360-X)
Sloan, A. J., Moseley, R., Dobie, K., Waddington, R. J. and Smith, A. J. 2002. TGF-beta latency-associated peptides (LAPs) in human dentin matrix and pulp. Connective Tissue Research 43(2-3), pp. 381-386. (10.1080/03008200290000916)
Moseley, R., Waddington, R. J. and Embery, G. 2002. Hyaluronan and its potential role in periodontal healing. Dental Update 29(3), pp. 144-148.
Moseley, R., Waddington, R. J. and Embery, G. 2002. The degradation of hyaluronan during periodontal diseases: A potential role for reactive oxygen species. In: Kennedy, J. F. et al. eds. Hyaluronan, Volume 2. Biomedical, Medical and Clinical Aspects. Cambridge: Woodhead Publishing Ltd, pp. 223-230.

2000

Waddington, R. J., Moseley, R. and Embery, G. 2000. Periodontal disease mechanisms - Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Diseases 6(3), pp. 138-151. (10.1111/j.1601-0825.2000.tb00325.x)

1998

Moseley, R., Waddington, R. J., Embery, G. and Rees, S. G. 1998. The modification of alveolar bone proteoglycans by reactive oxygen species in vitro. Connective Tissue Research 37(1-2), pp. 13-28. (10.3109/03008209809028897)

1997

Moseley, R., Waddington, R. J. and Embery, G. 1997. Degradation of glycosaminoglycans by reactive oxygen species derived from stimulated polymorphonuclear leukocytes. Biochimica et Biophysica Acta - Molecular Basis of Disease 1362(2-3), pp. 221-231. (10.1016/S0925-4439(97)00083-5)

1996

Taylor, G. C., Waddington, R. J., Moseley, R., Williams, K. R. and Embery, G. 1996. Influence of titanium oxide and titanium peroxy gel on the breakdown of hyaluronan by reactive oxygen species. Biomaterials 17(13), pp. 1313-1319. (10.1016/S0142-9612(96)80008-1)

1995

Moseley, R., Waddington, R. J., Evans, P., Halliwell, B. and Embery, G. 1995. The chemical modification of glycosaminoglycan structure by oxygen-derived species in vitro. Biochimica et Biophysica Acta (BBA) - General Subjects 1244(2-3), pp. 245-252. (10.1016/0304-4165(95)00010-9)

Recent Research Grant Awards

Wellcome Trust (2017-18). Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis. £49,995. Principle Investigator.
Medical Research Council (MRC) (2017-18). Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts. £49,993. Principle Investigator.
Royal Botanical Gardens Kew (2018-19). Evaluation of the modulatory effects of plant-derived saps on neutrophil and macrophage responses associated with impaired healing, tropical ulcers. £6,600. Principle Investigator.
QBiotics Group (2018-19). Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts. £127,762. Principle Investigator.
Cardiff University Vice-Chancellor’s International Scholarship for Research Excellence & the School of Dentistry, Cardiff University (2018-21). Novel cancer drugs, EBC-46 and IngM, regulate disintegrin and metaplloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer. £129,973. Co-Investigator.
QBiotics Group (2019-21). Elucidation of the downstream signalling mechanisms by which epoxy-tiglianes promote preferential dermal wound healing responses. £165,925. Principle Investigator.
Kingdom of Saudi Arabia Government, PhD Studentship (2019-21). Ophthalmic applications of pomegranate extracts. £105,970. Co-Investigator.
Kingdom of Saudi Arabia Government, PhD Studentship (2019-22). Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana). £107,850. Co-Investigator.
Phillips Research (2020-23). Investigating the effects of blue light on cells of the periodontium. £112,211. Co-Investigator.
Dunhill Medical Trust (2021-23). Development of epoxy-tiglianes as novel small molecule therapeutics for impaired re-epithelialisation associated with non-healing, chronic skin wounds in the aged. £298,338. Principle Investigator.
QBiotics Group (2021-23). Elucidation of the mechanisms by which epoxy-tiglianes promote preferential wound healing responses in dermal fibroblasts. £272,205. Principle Investigator.
Knowledge Economy Skills Scholarships (KESS2) East Wales and Cultech Ltd. (2022-23). The impact of probiotic bacteria on intestinal barrier function. £22,202. Principle Investigator.

Filed Patents

Convatec Wound Care Ltd. EP1245239A1 and US2003040690A1, relating to the antioxidant properties of wound dressing-based, biomaterials.
Johnson and Johnson Wound Management Ltd. (Systagenix Wound Management Ltd.). EP1889069A1, EP1889069B1, GB2426335A, US8491852B2, US2009299161A1 and WO2006123091A1, relating to the use of total antioxidant capacity as a prognostic/diagnostic biomarker of chronic wound infection and healing.
Johnson and Johnson Wound Management Ltd. (Systagenix Wound Management Ltd.). GB2447865A, US2010166694, US2012010099A1, US8012698B2 and WO2008119974A1, relating to the quantification of various cytokines and growth factors as prognostic/diagnostic biomarkers of diabetic foot ulcer wound infection and healing.
Peplin Inc. (LEO Pharma A/S). AU20050906601, AU2006317523A1, AU20100213362A1, AU20100213362B2, BRPI0618926A2, CA2629899A1, CA2752389A1, CA2752389C, CN101360506A, CN102316866A, DK2395993T3, EP1965818A1, EP1965818A4, EP2395993A1, EP2395993A4, EP2395993B1, ES2633755T3, IL214133A, JP2009517345A, JP2012517450A, JP5638008B2, KR20080077625A, NZ568168A, NZ594184A, PL2395993T3, PT2395993T, RU2011137530A, RU2491050C2, US10143638B2, US2009215884A1, US2012041064A1, US2016317486A1, WO2007059584A1; and WO2010091472A1, relating to the application of ingenol mebutate and related compounds in the promotion of dermal wound healing and reduced scarring.
QBiotics Group. AU2014253608A1, AU2014253608B2, BR112015026388A2, BR112015026388A8, CA2909653A1, CN105308052A, CN105308052B, CY1121515T1, DK2986615T3, EA032501B1, EA032501B9, EA201591996A1, EP2986615A1, EP2986615A4, EP2986615B1, ES2715105T3, HK1214256A1, HRP20190435T1, HUE043272T2, IL242137A, JP2016522801A, JP6415538B2, KR102147796B1, KR20160023651A, LT2986615T, MX2015014607A, MX365255B, NZ713954A, PH12015502405A1, PH12015502405B1, PL2986615T3, PT2986615T, RS58532B1, SG11201508588XA, SI2986615T1, TR201903565T4, UA118670C2, US10183921B2, US10183922B2, US10822317B2, US2016068499A1, US2017144981A1, US2019161462A1, WO2014169356A1; and ZA201508186B, relating to the application of epoxy-tigliane compounds, such as EBC-46, in the promotion of dermal wound healing and reduced scarring.

External Collaborators

Professor Glen Boyle. QIMR Berghofer Medical Research Institute, Australia.
Professor Alastair Sloan. University of Melbourne, Australia.
Dr Paul Reddell. QBiotics Group, Australia.
Dr Steven Ogbourne, Dr Fraser Russell. University of the Sunshine Coast, Australia.
Professor Matthias Born, Dr Monique Stoffels, Pieter Horstman. Phillips Research, The Netherlands.
Dr Tom Prescott. Royal Botanical Gardens Kew, UK.
Dr Daryn Michael, Dr Susan Plummer. Cultech Ltd., UK.

Cardiff University Collaborators

School of Biosciences: Dr Ahmed Ali.
School of Dentistry: Professor Rachel Waddington, Professor Daniel Aeschlimann, Dr Vera Knäuper, Dr Sharon Dewitt.
School of Medicine: Dr Robert Steadman.
School of Pharmacy and Pharmaceutical Sciences: Dr Charles Heard.

Current Postgraduate Students

Co-Supervisor

Frank Antwi (PhD student, Year 3). Novel cancer drugs, EBC-46 and IngM, regulate disintegrin and metaplloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer.
Ahmed Asiri (PhD student, Year 3). Ophthalmic applications of pomegranate extracts (in collaboration with the School of Pharmacy & Pharmaceutical Sciences and the School of Optometry & Vision Sciences, Cardiff University).
Abdulaziz Alqarni (PhD student, Year 3). Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana) (in collaboration with the School of Pharmacy & Pharmaceutical Sciences and the School of Biosciences, Cardiff University).
Edward Gait-Carr (PhD student, Year 3). Investigating the effects of blue light on cells of the periodontium.

Current Postdoctoral Research Staff

Dr Jordanna Dally. Development of epoxy-tiglianes as novel small molecule therapeutics for impaired re-epithelialisation associated with non-healing, chronic skin wounds in the aged (in collaboration with the School of Medicine, Cardiff University).
Dr Emma Woods. Elucidation of the mechanisms by which epoxy-tiglianes promote preferential wound healing responses in dermal fibroblasts (in collaboration with the School of Medicine, Cardiff University).

Undergraduate Teaching

BDS Dental Undergraduates

Lecture to Year 1 BDS students as part of the ‘Oral Ecosystems’ Theme, on (i) dental-pulp complex.
Lecture and provide revision tutorials to Year 2 BDS students as part of the ‘Oral Ecosystems’ Theme, including (i) prenatal jaw development, (ii) alveolar bone and cementum, and (iii) osseointegration.
Provide practical sessions to Year 1 BDS on (i) dental-pulp complex.
Provide practical sessions to Year 2 BDS on (i) dentinogenesis and (ii) prenatal jaw development.
Organize all Year 2 BDS revision tutorial sessions.
Setting/assessment of Year 2 BDS Teaching-Based Learning (TBL) Exercises.
Setting/marking of in-course assessments and examination papers for Year 2 BDS.
Supervision of Year 5 BDS research projects.
Academic and Personal Tutor to a number of Year 2 BDS students.

BSc Dental Therapy and Hygiene Undergraduates

Lecture to Year 1 BSc students as part of the ‘Biomedical Sciences’ Module, including (i) tissues and organs; and (ii) dental-pulp complex and dentine sensitivity.

MPharm Pharmacy Undergraduates

Lecture to Year 3 MPharm students as part of the 'Diseases and Drugs, 2' Module, on (i) mechanisms of dermal wound healing.
Setting/marking of examination papers for MPharm Programme.

Postgraduate Teaching

MSc in Tissue Engineering

Provide lectures on (i) impaired dermal wound healing, (ii) modelling of cell-extracellular matrix interactions in vitro; and (iii) large-scale tissue/organ engineering in vitro, for the ‘Tissue Engineering: Concept-Clinical Practice’ Module.
Provide lectures on (i) skin in health, for the ‘Cellular and Molecular Biology’ Module.
Setting/marking of in-course assessments and examination papers.
Supervision of laboratory-based, MSc research projects.

MSc in Implantology

Provide lectures and revision tutorials on (i) the principles of osseointegration; (ii) cytokines and growth factors in bone repair; and (iii) proteinase and bone repair; for the ‘Implantology’ and ‘Cellular and Molecular Biology’ Modules.
Setting/marking of in-course assessments and examination papers.

MSc in Clinical Dentistry

Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) proteinase and bone repair; as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Orthodontics

Provide lectures on (i) cytokines and growth factors in bone repair, as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Oral Biology

Provide lectures on (i) histology of healthy tissues, for the 'Cell Biology of Oral Tissues' Module.
Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) fibroblast heterogeneity and wound healing, for the 'Tissue Repair, Regeneration and Scientific Methods’ Module.
Setting/marking of in-course assessments and examination papers.
Supervision of laboratory-based, MSc research projects.

I graduated with a 2.1 BSc (Honours) degree in Biochemistry from Swansea University in 1991, before commencing an MRC-funded, PhD at the School of Dentistry, University of Wales College of Medicine (UWCM) in 1992. I completed my PhD in 1996, before embarking on Postdoctoral Researcher positions at UWCM/Cardiff University, funded by the British Heart Foundation (1996-98), Wellcome Trust (1998-00) and Johnson & Johnson Wound Management Ltd. (2002-08); in addition to being appointed as a Locum Lecturer in Oral Biochemistry within the School of Dentistry (2000-02). In 2008, I was appointed Lecturer in Tissue Repair within the School of Dentistry, being promoted to Senior Lecturer in 2012, Reader in 2017, and Professor in 2022.

Qualifications

2010: Postgraduate Certificate in University Teaching and Learning (PCUTL). Cardiff University, UK.
1996: PhD (Oral Biochemistry), Thesis entitled ‘Structural Changes in Periodontal Proteoglycans by Reactive Oxygen Species’. School of Dentistry, University of Wales College of Medicine, UK.
1993: Diploma in Biomedical Methods, University of Wales College of Medicine, UK.
1991: BSc (Honours) Degree in Biochemistry, Swansea University, UK.

Honours and awards

2022: Septodont poster prize. Pan European (PER)/International Association for Dental Research (IADR) Meeting, Marseille, France (PhD student, Edward Gait-Carr).
2021: Oral presentation prize, Cardiff University School of Dentistry Research Day. Cardiff, UK (PhD student, Edward Gait-Carr).
2020: Poster prize, Cardiff University Postgraduate Research Day. Cardiff, UK (PhD student, Vildan Celiksoy).
2019: Poster prize, Cardiff University School of Dentistry Research Day. Cardiff, UK (Postdoctoral Research Associate, Dr Jordanna Dally).
2018: Poster prize, Cardiff University Postgraduate Research Day. Cardiff, UK (PhD student, Nadia Alaidaroos).
2017: Poster prize, European Tissue Repair Society (ETRS) Meeting. Brussels, Belgium (PhD student, Glyn Morris).
2017: Oral presentation prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting. Cardiff, UK (PhD student, Glyn Morris).
2015: Oral presentation prize, Sêr Cymru (Life Sciences Research Network Wales) Meeting. Cardiff, UK (PhD student, Jordanna Dally).
2015: Poster prize, Cardiff University Postgraduate Research Day. Cardiff, UK (PhD student, Jordanna Dally).
2014: Poster prize, European Tissue Repair Society (ETRS) Meeting. Edinburgh, UK (PhD student, Rachael Moses).
2013: Poster prize, Cardiff University Postgraduate Research Day. Cardiff, UK (PhD student, Rachael Moses).
2012: British Society for Oral and Dental Research (BSODR) Unilever poster prize, Pan European (PER)/International Association for Dental Research (IADR) Meeting. Helsinki, Finland (PhD student, Amr Alraies).
2012: Poster prize, Cardiff University Stem Cell Research Day. Cardiff, UK (PhD student, Amr Alraies).
2010: Jackson Prize for Burns and Plastic Surgery Research, Society for Academic and Research Surgery Conference. London, UK (PhD student, Joseph Hardwicke).
2008: Poster prize, Cardiff University Metabolism, Regeneration and Repair Group Meeting. Cardiff, UK (PhD student, Joseph Hardwicke).
2007: Oral presentation prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting. Abergavenny, UK (PhD student, Joseph Hardwicke).
2007: Oral presentation prize, Cardiff University Metabolism, Regeneration and Repair Group Meeting. Cardiff, UK (PhD student, Joseph Hardwicke).
2007: Poster prize, International Symposium on Polymer Therapeutics Meeting. Berlin, Germany (PhD student, Joseph Hardwicke).
2006: Oral presentation prize, Cardiff University Postgraduate Research Day. Cardiff, UK (PhD student, Joseph Hardwicke).
2006: Poster prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting. Cardiff, UK (PhD student, Joseph Hardwicke).
2003: Oral presentation prize, European Tissue Repair Society (ETRS) Meeting. Cardiff, UK (MD student, Joanna Hilton).
1998-2000: Honorary Research Fellow. School of Dentistry, University of Birmingham. Birmingham, UK.

Professional memberships

Member of the Association of Science Educators in Dentistry (ASEiD).
Member of the British Society for Oral and Dental Research (BSODR).
Member of the Cardiff Institute for Tissue Engineering and Repair (CITER).
Member of the European Tissue Repair Society (ETRS).
Fellow of the Higher Education Academy (HEA).
Member of the International Association for Dental Research (IADR).
Member of STEM Learning.

Academic positions

2012-17: Senior Lecturer in Tissue Repair and Programme Director, CITER MSc in Tissue Engineering. Stem Cells, Wound Repair and Regeneration, Oral and Biomedical Sciences, School of Dentistry, Cardiff University, UK.
2008-12: Lecturer in Tissue Repair and Programme Director, CITER MSc in Tissue Engineering. Wound Biology Group, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, UK.
2002-08: Senior Postdoctoral Research Officer. Wound Biology Group, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, UK.
2000-02: Locum Lecturer in Oral Biochemistry. Matrix Biology and Tissue Repair Research Unit, Department of Dental Health and Biological Sciences, School of Dentistry, University of Wales College of Medicine, UK.
1998-00: Postdoctoral Research Fellow, funded by The Wellcome Trust. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, UK.
1996-98: Postdoctoral Research Fellow, funded by The British Heart Foundation. Department of Cardiology and the Institute of Nephrology, University of Wales College of Medicine, UK.

Committees and reviewing

Editorial Boards

Biomolecules.
Current Research in Regenerative Medicine.
Dermato.
Future Pharmacology.
Journal of Oral Biology.
Review Editor, Regenerative Dentistry Editorial Board, Frontiers in Dental Medicine.
Review Editor, Craniofacial Biology and Dental Research Editorial Board, Frontiers in Physiology.

Lead Guest Editorships for Journal Special Issues

2020-21: Cellular and Molecular Mechanisms of Wound Healing. Biomolecules. Dr R Moseley, Dr AC Midgley (Nankai University, China) and Dr R Steadman (Cardiff University, UK). https://www.mdpi.com/journal/biomolecules/special_issues/Wound_Healing_Biomolecules
2020-21: MSC Heterogeneity: Emerging Molecular Characteristics Distinguishing Superior Quality Sub-populations for Regenerative Medicine. Stem Cells International. Dr R Moseley, Professor AJ Sloan (University of Melbourne, Australia), Dr LC Davies (Karolinska Institute, Sweden) and Dr JS Colombo (University of Nevada Las Vegas, USA). https://www.hindawi.com/journals/sci/si/642162/
2022-: Impact of Uncontrolled Diabetes on Oral Disease Progression and Healing. Frontiers in Dental Medicine and Frontiers in Oral Health. Professor R Moseley and Professor RJ Waddington (Cardiff University, UK). https://www.frontiersin.org/research-topics/40393/impact-of-uncontrolled-diabetes-on-oral-disease-progression-and-healing
2022-: Naturally-Sourced Biomolecules, Their Regulatory Actions, and Applications in Chronic Disease Management. Biomolecules. Dr AC Midgley (Nankai University, China), Dr X Yao (Shaanxi University of Science and Technology, China) and Professor R Moseley. https://www.mdpi.com/journal/biomolecules/special_issues/S84F34G2KW

Grant and Manuscript Reviewer

Grant reviewer for funders, including BBSRC, EPSRC, MRC, National Institute for Health Research (NIHR), Marie Skłodowska-Curie COFUND Fellowship Programme, AO Foundation, Austrian Research Promotion Agency (FFG), Dunhill Medical Trust, Qatar National Research Fund, Kidney Research UK, and the International Rett Syndrome Foundation.

Manuscript reviewer for >70 different journals, including Biomaterials, Journal of Investigative Dermatology, Journal of Dental Research, Stem Cell Research and Therapy, ACS Applied Materials & Interfaces, Scientific Reports, Free Radicals in Biology and Medicine, Biochemical Pharmacology, Journal of Controlled Release, Acta Biomaterialia, Biomolecules, Antioxidants, and Pharmaceutics.

Conference Prize Reviewer

2022: Young Investigators’ Oral Presentation Reviewer. European Tissue Repair Society (ETRS) Conference (Lyon, France).
2022: Senior Colgate Prize Reviewer. Pan European (PER)/International Association for Dental Research (IADR) Meeting (Marseille, France).
2021: Senior Colgate Prize Reviewer. British Society for Oral and Dental (BSODR) Research Meeting (Birmingham, UK).
2020: Senior Colgate Prize Reviewer. British Society for Oral and Dental (BSODR) Research Meeting (Virtual).
2019: Senior Colgate Prize Reviewer. British Society for Oral and Dental Research (BSODR) Meeting (Leeds, UK).
2018: Mineralised Tissue (MINTIG) Prize Reviewer. Pan European (PER)/International Association for Dental Research (IADR) Meeting (London, UK).
2018: Senior Colgate Prize Reviewer. Pan European (PER)/International Association for Dental Research (IADR) Meeting (London, UK).
2016: Senior Colgate Prize Reviewer. Pan European (PER) Dental Research Meeting (Jerusalem, Israel).
2015: Mineralised Tissue (MINTIG) Prize Reviewer. British Society for Oral and Dental Research (BSODR) Meeting (Cardiff, UK).
2014: Young Investigators’ Oral Presentation Reviewer. European Tissue Repair Society (ETRS) Conference (Edinburgh, UK).
2013: Mineralised Tissue (MINTIG) Prize Reviewer. British Society for Oral and Dental Research (BSODR) Meeting (Bath, UK).
2012: Mineralised Tissue (MINTIG) Prize Reviewer. Pan European (PER)/International Association for Dental Research (IADR) Meeting (Helsinki, Finland).
2011: Senior Colgate Prize Reviewer. British Society for Oral and Dental Research (BSODR) Meeting (Sheffield, UK).
2010: Mineralised Tissue (MINTIG) Prize Reviewer. Pan European (PER)/International Association for Dental Research (IADR) Meeting (Barcelona, Spain).
2009: Mineralised Tissue (MINTIG) Prize Reviewer. British Society for Dental Research (BSDR) Meeting (Glasgow, UK).
2008: Senior Colgate Prize Reviewer. Pan European (PER) Dental Research Meeting (London, UK).
2007: Mineralised Tissue (MINTIG) Prize Reviewer. British Society for Dental Research (BSDR) Meeting (Durham, UK).

External Thesis Examiner

2021: PhD Examiner. King's College London, UK.
2019: PhD Examiner. King's College London, UK.
2018: PhD Examiner. Queen Mary University of London, UK.
2018: MRes Examiner. Swansea University, UK.
2015: PhD Examiner. Swansea University, UK.
2012: PhD Examiner. University of Birmingham, UK.
2009: MRes Examiner. Swansea University, UK.

Internal Thesis Examiner

2022: PhD Examiner. School of Pharmacy and Pharmaceutical Sciences.
2021: PhD Examiner. School of Dentistry.
2020: PhD Examiner. School of Dentistry.
2017: PhD Examiner. School of Medicine.
2016: PhD Examiner. School of Dentistry.
2016: PhD Examiner. School of Medicine.
2014: PhD Examiner. School of Dentistry.
2014: PhD Examiner. School of Medicine.
2012: PhD Examiner. School of Medicine.
2012: MD Examiner. School of Medicine.
2012: MScD Examiner. School of Dentistry.
2010: MScD Examiner. School of Dentistry.

External Committees and Responsibilities

2021-present: Elected Board Member. European Tissue Repair Society (ETRS).
2021-present: Chair of the Regenerative Dentistry Research Group. British Society for Oral and Dental Research (BSODR), UK.

University Committees and Responsibilities

2021-present: Lead Tutor for Postgraduate Taught (Non-Clinical) Student and Postgraduate Research Student Programmes. School of Dentistry, Cardiff University, UK.
2021-present: Member of the School Board. School of Dentistry, Cardiff University, UK.
2021-present: Member of the Cardiff University Biobank Review Committee. Cardiff University, UK.
2019-present: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Executive Board. Cardiff University, UK.
2018-present: Deputy Director of International. School of Dentistry, Cardiff University, UK.
2018-19: Deputy Chair of the Cardiff Institute for Tissue Engineering and Repair (CITER) Research Committee. Cardiff University, UK.
2016-present: Member of the Admissions and Monitoring Committee for Postgraduate Research Programmes. School of Dentistry, Cardiff University, UK.
2016-19: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Research Committee. Cardiff University, UK.
2015-present: International Student Mobility Exchange Coordinator. School of Dentistry, Cardiff University, UK.
2015-present: Member of the Student International Mobility Group and College Student International Committee. College of Life and Biomedical Sciences, Cardiff University, UK.
2015-17: Member of the Web Editorial Board. School of Dentistry, Cardiff UniversIty, UK.
2014-17: Member of the Research Ethics Committee. School of Dentistry, Cardiff University, UK.
2014-15: Member of the Programme Advisory Panel for the MRes Programme in 'Medical Research and Innovation'. School of Medicine, Cardiff University, UK.
2010-present: Member of the Staff-Student Panel for Undergraduate Programmes. School of Dentistry, Cardiff University, UK.
2009-18: Member of the Admissions and Monitoring Committee for Taught Programmes. School of Dentistry, Cardiff University, UK.
2008-18: Director for the Cardiff Institute for Tissue Engineering and Repair (CITER) MSc Programme in Tissue Engineering. Cardiff University, UK.
2008-16: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Learning, Teaching and Engagement Committee. Cardiff University, UK.
2008-13: Member of the Postgraduate Board of Studies Committee. School of Dentistry, Cardiff University, UK.
2008-11: Member of the Staff-Student Panel Committee for Taught Programmes. School of Dentistry, Cardiff University, UK.
2008-09: Member of the Postgraduate Suite Task Group Committee. School of Dentistry, Cardiff University, UK.
2007-08: Deputy Radiation Protection Supervisor. School of Dentistry, Cardiff University, UK.
2004-18: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) MSc Programme in Tissue Engineering Board of Studies Committee. Cardiff University, UK.
2001-04: Member of the Year 4 BDS Dental Undergraduate Elective Committee. School of Dentistry, Cardiff University, UK.
1993-95: Secretary of the Postgraduate Society. University of Wales College of Medicine, Cardiff, UK.

I am currently interested in supervising PhD students in the following areas:

Mechanisms underlying oral mucosal and dermal wound healing responses.
Drug development for enhanced wound healing outcomes in skin.
Dental pulp stem cell (DPSC) heterogeneity.
Oxidative stress and impaired diabetic bone healing.