![Simon Noble](https://profiles-cardiff.imgix.net/attachments/2524?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
I hold a Marie Curie Chair in Supportive and Palliative Medicine and am co-director of the Marie Curie Palliative Care Reserch Group, which sits in the Division of Population Medicine. I am also an honorary consultant in Palliative Medicine at Aneurin Bevan Universirty Health Board
My research and clinical interests lie with cancer associated thrombosis with particular emphasis on management in advanced cancer and where the evidence is lacking. I have collaborated with international researchers to explore the impact of cancer associated thrombosis on the lives of patients with cancer associated thrombosis and am a strong advocate for patient partner working in all apsect of thrombosis research.
I believe the management of conditions affecting palliative care patients should be evidenced based and that it is essential for good patient care that we challenge dogma which is based on poor evidence. Dying is the one clinical process that every patient will experience. We owe it to our patients (and ourselves) to ensure the evidence base of end of life care is held to the same scrutiny as newly marketed pharmaceuticals.
I have lectured in over 40 countries across five continents. My hobbies include trekking, the history of cinema and hip-hop.
Publication
2024
- Ording, A. G. et al. 2024. Time toxicity of systemic anticancer therapy for metastatic lung cancer in routine clinical practice: A nationwide cohort study. JCO Oncology Practice (10.1200/op-24-00526)
- Edwards, M. et al. 2024. Involving patients and the public in cancer associated thrombosis research: a strategy for success.. Thrombosis Update, article number: 100196. (10.1016/j.tru.2024.100196)
- Martens, E. et al. 2024. Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis 245, article number: 109205. (10.1016/j.thromres.2024.109205)
- Ahmed, H., Davies, A., Daniel, R., Noble, S. and Farewell, D. 2024. Antibiotic prescribing patterns and risk of antibiotic-resistant infections and clostridium difficile in Warfarin and direct oral anticoagulant users: matched population-based cohort study. Discover Public Health 21(1), article number: 132. (10.1186/s12982-024-00263-1)
- Søgaard, M. et al. 2024. Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: A Danish nationwide cohort study. Journal of Thrombosis and Haemostasis (10.1016/j.jtha.2024.09.023)
- Ording, A. G. et al. 2024. Risk of venous thromboembolism in patients with stage III and IV non-small cell lung cancer: Nationwide descriptive cohort study. Clinical Lung Cancer 25(5), pp. 407-416. (10.1016/j.cllc.2024.04.004)
- Alikhan, R., Gomez, K., Maraveyas, A., Noble, S., Young, A. and Thomas, M. 2024. Cancer‐associated venous thrombosis in adults (second edition): A British Society for Haematology Guideline. British Journal of Haematology 205(1), pp. 71-87. (10.1111/bjh.19414)
- Nelson, A. et al. 2024. Chemotherapy decision-making in advanced lung cancer: a prospective qualitative study. BMJ Supportive & Palliative Care 14(1), pp. e758-e764. (10.1136/bmjspcare-2020-002395)
- Noble, S. 2024. Patient and public involvement in cancer-associated thrombosis research: necessary or glorified tokenism?. Bleeding, Thrombosis and Vascular Biology 3(s1) (10.4081/btvb.2024.125)
- Haire, E., Mann, M., Yeoman, A., Atkinson, C., Wright, M. and Noble, S. 2024. Supportive and palliative care needs in advanced non-malignant liver disease: systematic review. BMJ Supportive & Palliative Care (10.1136/spcare-2024-004785)
- Ahmed, H., Reeve, N., Farewell, D., Hamilton, F., Ponsford, M., Hippisley‐Cox, J. and Noble, S. 2024. Risk of bleeding amongst warfarin and direct oral anticoagulant users prescribed immediate antibiotics for respiratory tract infection: cohort study. Pharmacoepidemiology & Drug Safety 33(5), article number: e5794. (10.1002/pds.5794)
- Mørkved, A. L. et al. 2024. Risk and timing of venous thromboembolism after surgery for lung cancer: a nationwide cohort study. The Annals of Thoracic Surgery 117(2), pp. 289-296. (10.1016/j.athoracsur.2023.10.015)
- Ahmed, H., Davies, A., Daniel, R., Noble, S. and Farewell, D. 2024. Antibiotic prescribing patterns and risk of antibiotic-resistant infections and Clostridium difficile in Warfarin and Direct Oral Anticoagulant users: matched population-based cohort study. Discover Public Health 21(1), article number: 132. (10.1186/s12982-024-00263-1)
2023
- Ording, A. G. et al. 2023. Risk of recurrent cancer-associated venous thromboembolism: A Danish nationwide cohort study. International Journal of Cardiology 390, article number: 131271. (10.1016/j.ijcard.2023.131271)
- Kitson, T. et al. 2023. HIDDEN2: Study protocol for the hospital deep vein thrombosis detection study in patients with cancer receiving palliative care. BMJ Open 13(9), article number: e073049. (10.1136/bmjopen-2023-073049)
- Goedegebuur, J. et al. 2023. Towards optimal use of antithrombotic therapy of people with cancer at the end of life: a research protocol for the development and implementation of the SERENITY shared decision support tool. Thrombosis Research 228, pp. 54-60. (10.1016/j.thromres.2023.05.008)
- Bravington, A. et al. 2023. Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction. PLoS ONE 18(8), article number: e0289501. (10.1371/journal.pone.0289501)
- Berman, R. et al. 2023. The rise of supportive oncology: a revolution in cancer care. Clinical Oncology 35(4), pp. 213-215. (10.1016/j.clon.2023.01.015)
- Crabtree, A. et al. 2023. Right needle, right patient, right time? A national flash-mob audit of thromboprophylaxis in palliative care. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis 223, pp. 95-101. (10.1016/j.thromres.2023.01.021)
- Barry, C., Paes, P., Noble, S. and Davies, A. 2023. Challenges to delivering evidence-based palliative medicine. Clinical Medicine 23(2), pp. 182-184. (10.7861/clinmed.2022-0336)
2022
- Clare, W. et al. 2022. Hospice inpatient deep vein thrombosis detection (HIDDen) in advanced non-malignant diseases: a longitudinal pilot study. BMJ Supportive and Palliative Care 12(e6), pp. e767-e770. (10.1136/bmjspcare-2019-002039)
- Overvad, T. F., Skjøth, F., Piazza, G., Noble, S., Ording, A. G., Larsen, T. B. and Nielsen, P. B. 2022. The Khorana score and venous and arterial thrombosis in patients with cancer treated with immune checkpoint inhibitors: a Danish cohort study. Journal of Thrombosis and Haemostasis 20(12), pp. 2921-2929. (10.1111/jth.15883)
- Bravington, A. et al. 2022. The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: a systematic review. Palliative Medicine 36(9), pp. 1336-1350. (10.1177/02692163221122352)
- Dinnen, T. et al. 2022. Patient safety incidents in advance care planning for serious illness: a mixed-methods analysis. BMJ Supportive and Palliative Care 12(e3), pp. e403-e410. (10.1136/bmjspcare-2019-001824)
- Baddeley, E. et al. 2022. Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review. Palliative Medicine 36(6), pp. 895-911. (10.1177/02692163221081331)
- Seddon, K., Elliott, J., Johnson, M., White, C., Watson, M., Nelson, A. and Noble, S. 2022. Using the United Kingdom standards for public involvement to evaluate the impact of public involvement in a multinational clinical study. Research Involvement and Engagement 7(1), article number: 22. (10.1186/s40900-021-00264-3)
2021
- Baddeley, E., Torrens-Burton, A., Newman, A., Nelson, A., Pease, N., Nelson, R. and Noble, S. 2021. A mixed-methods study to evaluate a patient-designed tool to reduce harm from cancer-associated thrombosis: The EMPOWER study. Research and Practice in Thrombosis and Haemostasis 5(5), article number: e12545. (10.1002/rth2.12545)
- Ording, A. G. et al. 2021. Increasing incidence and declining mortality after cancer-associated venous thromboembolism: a nationwide cohort study. American Journal of Medicine 134(7), pp. 868-876., article number: e5. (10.1016/j.amjmed.2021.01.031)
- Gleeson, A., Noble, S. and Mann, M. 2021. Advance care planning for home health staff: a systematic review. BMJ Supportive and Palliative Care 11(1), pp. 209-216. (10.1136/bmjspcare-2018-001680)
- Lyman, G. H. et al. 2021. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Advances 5(4), pp. 927-974. (10.1182/bloodadvances.2020003442)
- Højen, A. A., Søgaard, M., Seddon, K. and Noble, S. 2021. Patient public involvement and engagement in thrombosis research: not just for the intrepid. Research and Practice in Thrombosis and Haemostasis 5(1), pp. 245-246. (10.1002/rth2.12451)
- Ahmed, H., Whitaker, H., Farewell, D., Hippisley-Cox, J. and Noble, S. 2021. Respiratory tract infection and risk of bleeding in oral anticoagulant users: self-controlled case series. British Medical Journal 2021, article number: 375. (10.1136/bmj-2021-068037)
2020
- Bennett, P., Noble, S., Johnston, S., Jones, D. and Hunter, R. 2020. Covid confessions: a qualitative exploration of health care workers experiences of working with covid-19. BMJ Open 10(12), article number: e043949. (10.1136/bmjopen-2020-043949)
- Schunemann, H. J. et al. 2020. Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis. Lancet Haematology 7(10), pp. e746-e755. (10.1016/S2352-3026(20)30293-3)
- Longo, M. et al. 2020. Holistic care: the clinical nurse specialist’s role in advanced lung cancer patients. Palliative Medicine 34(Supple), pp. 79-79. (10.1177/0269216320958098)
- Es, N. et al. 2020. The Khorana score for prediction of venous thromboembolism in cancer patients: An individual patient data meta-analysis. Journal of Thrombosis and Haemostasis 18(8), pp. 1940-1951. (10.1111/jth.14824)
- Baddeley, E. et al. 2020. Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study. BMJ Open 10(6), article number: e039154. (10.1136/bmjopen-2020-039154)
- Ventresca, M. et al. 2020. Obtaining and managing data sets for individual participant data meta-analysis: scoping review and practical guide. BMC Medical Research Methodology 20, article number: 113. (10.1186/s12874-020-00964-6)
- Noble, S., Nelson, A., Scott, J., Berger, A., Schmidt, K., Swarnkar, P. and Lee, A. 2020. Patient experience of living with cancer-associated thrombosis in Canada (PELICANADA). Research and Practice in Thrombosis and Haemostasis 4(1), pp. 154-160. (10.1002/rth2.12274)
2019
- Watts, T., Willis, D., Noble, S. and Johnston, B. 2019. Death Rattle: reassuring harbinger of imminent death or a perfect example of inadequacies in evidence-based practice. Current Opinion in Supportive and Palliative Care 13(4), pp. 380-383. (10.1097/SPC.0000000000000463)
- Sivell, S. et al. 2019. Considerations and recommendations for conducting qualitative research interviews with palliative and end-of-life care patients in the home setting: a consensus paper. BMJ Supportive & Palliative Care 9, article number: e14. (10.1136/bmjspcare-2015-000892)
- Williams, H. et al. 2019. Quality improvement identifying priorities for safer out- of- hours palliative care: lessons from a mixed methods analysis of a national incident reporting database. Palliative Medicine 33(3), pp. 346-356. (10.1177/0269216318817692)
- White, C. et al. 2019. Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study. Lancet Haematology 6(2), pp. e79-e88. (10.1016/S2352-3026(18)30215-1)
2018
- Noble, S. 2018. Patient relevant bleeding complications; it's bleeding complicated. Thrombosis Research 172, pp. 179-180. (10.1016/j.thromres.2018.10.032)
- Samuelson Bannow, B. R., Lee, A. Y. Y., Khorana, A. A., Zwicker, J. I., Noble, S., Ay, C. and Carrier, M. 2018. Management of anticoagulation for cancer-associated thrombosis in patients with thrombocytopenia: A systematic review. Research and Practice in Thrombosis and Haemostasis 2(4), pp. 664-669. (10.1002/rth2.12111)
- Harrop, E., Nelson, A., Rees, H., Harris, D. and Noble, S. 2018. The challenge pathway: a mixed methods evaluation of an innovative care model for the palliative and end-of-life care of people with dementia (innovative practice). Dementia 17(2), pp. 252-257. (10.1177/1471301217729532)
- Collins, J. T. et al. 2018. The value of physical performance measurements alongside assessment of sarcopenia in predicting receipt and completion of planned treatment in non-small cell lung cancer: an observational exploratory study. Supportive Care in Cancer 26, pp. 119-127. (10.1007/s00520-017-3821-6)
2017
- Harrop, E., Noble, S., Edwards, M., Sivell, S., Moore, B. and Nelson, A. 2017. Managing, making sense of and finding meaning in advanced illness: a qualitative exploration of the coping and wellbeing experiences of patients with lung cancer. Sociology of Health & Illness 39(8), pp. 1448-1464.
- Bhatnagar, S., Gielen, J., Satija, A., Singh, S. P., Noble, S. and Chaturvedi, S. K. 2017. Signs of spiritual distress and its implications for practice in Indian palliative care. Indian Journal of Palliative Care 23(3), pp. 306-311. (10.4103/IJPC.IJPC_24_17)
- Anagnostou, D. et al. 2017. Development of an intervention to support patients and clinicians with advanced lung cancer when considering systematic anticancer therapy: protocol for the PACT study. BMJ Open 7(7), article number: e015277. (10.1136/bmjopen-2016-015277)
- Hunter, R., Lewis, S., Noble, S., Rance, J. and Bennett, P. D. 2017. "Post-thrombotic panic syndrome": a thematic analysis of the experience of venous thromboembolism. British Journal of Health Psychology 22(1), pp. 8-25. (10.1111/bjhp.12213)
2016
- Noble, S. et al. 2016. Impact of a dedicated cancer-associated thrombosis service on clinical outcomes: a mixed-methods evaluation of a clinical improvement exercise. BMJ Open 6(11), article number: e013321. (10.1136/bmjopen-2016-013321)
- Noble, S. 2016. Thromboembolic disease and breathlessness. Current Opinion in Supportive and Palliative Care 10(3), pp. 249-255. (10.1097/SPC.0000000000000228)
- Mahé, I., Chidiac, J., Helfer, H. and Noble, S. 2016. Factors influencing adherence to clinical guidelines in the management of cancer-associated thrombosis. Journal of Thrombosis and Haemostatis 14(11), pp. 2107-2113. (10.1111/jth.13483)
- Harrop, E., Noble, S., Edwards, M., Sivell, S., Moore, B. and Nelson, A. 2016. 'I didn't really understand it, I just thought it'd help': exploring the motivations, understandings and experiences of patients with advanced lung cancer participating in a non-placebo clinical IMP trial. Trials 17(1), article number: 329. (10.1186/s13063-016-1460-8)
- Bennett, P., Patterson, K. and Noble, S. I. R. 2016. Predicting post-traumatic stress and health anxiety following a venous thrombotic embolism. Journal of Health Psychology 21(5), pp. 863-871. (10.1177/1359105314540965)
- Font, C., Garcia-Fernandez, T., Nelson, A., Prout, H. and Noble, S. 2016. Patients' Experiences of LIving with CANcer associated thrOmbosis in Spain (PELICANOS). Thrombosis Research 140(S1), pp. S199-S199. (10.1016/S0049-3848(16)30194-3)
- Schünemann, H. J. et al. 2016. Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol. BMJ Open 6(4), article number: e010569. (10.1136/bmjopen-2015-010569)
- Noble, S. and Sui, J. 2016. The treatment of cancer associated thrombosis: does one size fit all? Who should get LMWH/warfarin/DOACs?. Thrombosis Research 140(S1), pp. S154-S159. (10.1016/S0049-3848(16)30115-3)
- Macbeth, F. et al. 2016. Randomized phase III trial of standard therapy plus low molecular weight heparin in patients with lung cancer: FRAGMATIC trial. Journal of Clinical Oncology 34(5), pp. 488-494. (10.1200/JCO.2015.64.0268)
- Gielen, J., Bhatnagar, S., Noble, S. I. R. and Chaturvedi, S. K. 2016. Development and psychometric assessment of a spirituality questionnaire for Indian palliative care patients. Indian Journal of Palliative Care 22(1), pp. 9. (10.4103/0973-1075.173939)
2015
- Noble, S. I. et al. 2015. A feasibility study to inform the design of a randomised controlled trial to identify the most clinically effective and cost-effective length of Anticoagulation with Low-molecular-weight heparin In the treatment of Cancer-Associated Thrombosis (ALICAT). Health Technology Assessment 19(83), pp. 1-94. (10.3310/hta19830)
- Noble, S. I. R. 2015. Palliation for haematological and solid tumours: what difference?. The Lancet Haematology 2(8), pp. e309-e310. (10.1016/S2352-3026(15)00128-3)
- Collins, J. et al. 2015. Association of sarcopenia and observed physical performance with attainment of multidisciplinary team planned treatment in non-small cell lung cancer: an observational study protocol. BMC Cancer 15, pp. 401-413., article number: 544. (10.1186/s12885-015-1565-6)
- Prout, H., Nelson, A. and Noble, S. 2015. The utility of PEmb-QoL and VEINES-QoL/Sym questionnaires in evaluating quality of life in the cancer associated thrombosis patient. Journal of Thrombosis and Haemostatis 13(S2), pp. 548., article number: PO109-TUE. (10.1111/jth.12993)
- Noble, S., Prout, H. and Nelson, A. 2015. Patients experiences of living with cancer associated thrombosis: the PELICAN study [Abstract]. Journal of Thrombosis and Haemostasis 13(S2), pp. 543-543. (10.1111/jth.12993)
- Davies, N. et al. 2015. Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thrombosis Research 135(6), pp. 1075-1080. (10.1016/j.thromres.2015.03.021)
- Noble, S., Prout, H. and Nelson, A. 2015. Patients' Experiences of LIving with CANcer-associated thrombosis: the PELICAN study. Patient Preference and Adherence 9, pp. 337-345. (10.2147/PPA.S79373)
- Watts, G. J., Nelson, A., Lester, J. S. and Noble, S. I. 2015. Quality of life measures relating to the skin toxicities of tyrosine kinase inhibitor (TKI) use in lung cancer what is in current use in the literature?. Lung Cancer 87(S1), pp. S33., article number: 84. (10.1016/S0169-5002(15)50083-4)
- Sivell, S. et al. 2015. Conducting qualitative research interviews with palliative and end of life care patients in the home setting: reflections and recommendations from an academic palliative care research centre [Conference Abstract]. BMJ Supportive and Palliative Care 5, article number: 117. (10.1136/bmjspcare-2014-000838.40)
- Mitchell, H., Noble, S. I. R., Finlay, I. G. and Nelson, A. 2015. Defining the palliative care patient: its challenges and implications for service delivery. BMJ Supportive & Palliative Care 5(4), pp. 46-52. (10.1136/bmjspcare-2012-000220rep)
2014
- Prentice, J., Nelson, A., Baillie, J., Osborn, H. and Noble, S. I. R. 2014. 'Don't blame the middle man': an exploratory qualitative study to explore the experiences of translators breaking bad news. Journal of the Royal Society of Medicine 107(7), pp. 271-276. (10.1177/0141076814527275)
- Noble, S. et al. 2014. ALICAT: Anticoagulation length in cancer associated thrombosis - a mixed-methods feasibility study. Thrombosis Research 133(Supp 2), pp. S220-S220. (10.1016/S0049-3848(14)50032-1)
- Noble, S., Seaman, S. and Nelson, A. 2014. Attitudes of cancer associated thrombosis patients to the novel oral anticoagulants: insights from qualitative interviews. Thrombosis Research 133, pp. S219-S219.
- Noble, S., Lewis, R., Whithers, J., Lewis, S. and Bennett, P. 2014. Long-term psychological consequences of symptomatic pulmonary embolism: a qualitative study. BMJ Open 4(4), article number: e004561. (10.1136/bmjopen-2013-004561)
- Seaman, S., Nelson, A. and Noble, S. I. R. 2014. Is long-term low-molecular-weight heparin still acceptable to palliative care patients in the treatment of cancer-associated thrombosis? A qualitative study revisited. BMJ Supportive & Palliative Care 4, pp. A25., article number: P 028. (10.1136/bmjspcare-2014-000654.69)
- Carrier, M., Khorana, A. A., Zwicker, J. I., Noble, S. and Lee, A. Y. Y. 2014. Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH: a reply to a rebuttal. Journal of Thrombosis and Haemostatis 12(1), pp. 116-117. (10.1111/jth.12444)
- Collins, J., Noble, S. I. R., Chester, J. D., Coles, B. M. and Byrne, A. 2014. The assessment and impact of sarcopenia in lung cancer: a systematic literature review. BMJ Open 4(1), article number: e003697. (10.1136/bmjopen-2013-003697)
- Smith, J. D. et al. 2014. A feasibility study to inform the design of a randomized controlled trial to identify the most clinically and cost effective Anticoagulation Length with low molecular weight heparin In the treatment of Cancer Associated Thrombosis (ALICAT): study protocol for a mixed-methods study. Trials 15(1), article number: 122. (10.1186/1745-6215-15-122)
- Noble, S. I. R. et al. 2014. Anticoagulation length in cancer associated thrombosis: a mixed-methods feasibility study. Presented at: International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, Italy, 9-11 May 2014.
2013
- Sheard, L., Prout, H., Dowding, D., Noble, S., Watt, I., Maraveyas, A. and Johnson, M. 2013. Barriers to the diagnosis and treatment of venous thromboembolism in advanced cancer patients: a qualitative study. Palliative Medicine 27(4), pp. 339-348.
2012
- Johnson, M. J., Sheard, L., Maraveyas, A., Noble, S. I. R., Prout, H. C., Watt, I. and Dowding, D. 2012. Diagnosis and management of people with venous thromboembolism and advanced cancer: how do doctors decide? A qualitative study. BMC Medical Informatics and Decision Making 12(1), pp. 75-88. (10.1186/1472-6947-12-75)
- Smith, J. et al. 2012. Improving outcomes for palliative lung cancer patients: experience of a multiprofessional parallel clinic model in a district general hospital [Abstract]. Lung Cancer 75(Supp 1), pp. S32. (10.1016/S0169-5002(12)70098-3)
- Noble, S. I. R. et al. 2012. Addressing the lung cancer research agenda through user partnership working: the Stepping Stones experience. Lung Cancer 75(Supp 1), pp. S25. (10.1016/S0169-5002(12)70076-4)
- Howison, H. et al. 2012. A survey of patient attitudes to attending a lung cancer nurse specialist (LCNS) follow up clinic. Lung Cancer 75(Supp 1), pp. S32.
- Edwards, M. et al. 2012. 110 Motivations of palliative lung cancer patients to participate in a non-placebo clinical trial (QualFRAG). Lung Cancer 75(s1), pp. s36.
- Noble, S. I. R. 2012. Low-molecular-weight heparin and survival in lung cancer. Thrombosis Research 129(S1), pp. S114-S118. (10.1016/S0049-3848(12)70029-4)
2011
- Gillon, S., Noble, S. I. R., Ward, J., Lodge, K., Nunn, A., Koon, S. and Johnson, M. 2011. Primary thromboprophylaxis for hospice inpatients: who needs it?. Palliative Medicine 25(7), pp. 701-705. (10.1177/0269216310397567)
- Harris, D. G., Flowers, S. and Noble, S. I. R. 2011. Nurses' views of the coping and support mechanisms experienced in managing terminal haemorrhage. International Journal of Palliative Nursing 17(1), pp. 7-13.
- Harris, D. G., Finlay, I. G., Flowers, S. and Noble, S. I. R. 2011. The use of crisis medication in the management of terminal haemorrhage due to incurable cancer: a qualitative study. Palliative Medicine 25(7), pp. 691-700. (10.1177/0269216311401464)
- Taubert, M., Noble, S. I. and Nelson, A. 2011. What challenges good palliative care provision out-of-hours? A qualitative interview study of out-of-hours general practitioners. BMJ Supportive & Palliative Care 1(1), pp. 13-18. (10.1136/bmjspcare-2011-000015)
2010
- Noble, S. I. R. and Johnson, M. 2010. Finding the evidence for thromboprophylaxis in palliative care: first let us agree on the question [Editorial]. Palliative Medicine 24(4), pp. 359-361. (10.1177/0269216310366389)
- Smith, C. et al. 2010. Maximising recruitment to lung cancer trials, a single centre experience of the FRAGMATIC trial [Abstract]. Lung Cancer 67(s1), pp. S22. (10.1016/S0169-5002(10)70064-7)
- Maraveyas, A., Johnson, M. J., Xiao, Y. P. and Noble, S. I. R. 2010. Malignant melanoma as a target malignancy for the study of the anti-metastatic properties of the heparins. Cancer and Metastasis Reviews 29(4), pp. 777-784. (10.1007/s10555-010-9263-y)
- Noble, S. I. R. and Pasi, J. 2010. Epidemiology and pathophysiology of cancer-associated thrombosis. British Journal of Cancer 102, pp. S2-S9. (10.1038/sj.bjc.6605599)
- Stansby, G., Noble, S. I. R. and Howes, O. 2010. The importance of venous thromboembolism - a physical consequence of psychiatric treatments [Editorial]. International Journal of Clinical Practice 64(8), pp. 1005-1006. (10.1111/j.1742-1241.2010.02435.x)
2009
- Noble, S. I. R., Parr, C., Yee, L. and Jiang, W. G. 2009. The effects of metastasis supressor-1 gene on the migratory properties of non small cell lung cancer [Abstract]. Lung Cancer 63(S1), pp. S3. (10.1016/S0169-5002(09)70007-8)
- Noble, S. I. R. and Jenkins, D. A. 2009. Management of venous thromboembolism in patients with cancer.. British Journal of Hospital Medicine 70(7), pp. 380-385.
- Macbeth, F. R., Griffiths, G. O., Noble, S. I. R., Burns, S. and Maughan, T. S. 2009. Interim safety data on the FRAGMATIC trial: a randomised phase III clinical trial investigating the effect of FRAGMin® added to standard therapy in patients with lung cancer [Abstract]. Journal of Thoraric Oncology 4(9), pp. S5-S968. (10.1097/JTO.0b013e3181b9c77e)
- Noble, S. I. R., Parr, C., Ye, L., Zhang, L. and Jiang, W. G. 2009. The impact of metastasis tumour supressor-1 (MTSS1) on the metastatic characteristics of non small cell lung cancer and its association with smoking history [Abstract]. Journal of Thoracic Oncology 4(9), pp. S630. (10.1097/JTO.0b013e3181b9c77e)
- Harris, D. G. and Noble, S. I. R. 2009. Management of terminal hemorrhage in patients with advanced cancer: a systematic literature review. Journal of Pain and Symptom Management 38(6), pp. 913-927. (10.1016/j.jpainsymman.2009.04.027)
- Griffiths, G. O., Burns, S., Noble, S. I. R., Macbeth, F. R., Cohen, D. and Maughan, T. S. 2009. Fragmatic: a randomised phase III clinical trial investigating the effect of fragmin® added to standard therapy in patients with lung cancer. BMC Cancer 9, pp. 355-363. (10.1186/1471-2407-9-355)
2008
- Noble, S. I. R., Nelson, A. and Finlay, I. G. 2008. Factors influencing hospice thromboprophylaxis policy: a qualitative study. Palliative Medicine 22(7), pp. 808-813. (10.1177/0269216308096723)
- Rowlands, J. and Noble, S. I. R. 2008. How does the environment impact on the quality of life of advanced cancer patients? A qualitative study with implications for ward design. Palliative Medicine 22(6), pp. 768-774. (10.1177/0269216308093839)
- Noble, S. I. R., Nelson, A. and Finlay, I. G. 2008. Challenges faced by palliative care physicians when caring for doctors with advanced cancer. Palliative Medicine 22(1), pp. 71-76. (10.1177/0269216307084607)
- Noble, S. I. R., Shelley, M. D., Coles, B. M., Williams, S. M., Wilcock, A. and Johnson, M. J. 2008. Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis. The Lancet Oncology 9(6), pp. 577-584. (10.1016/S1470-2045(08)70149-9)
2006
- Harris, D. and Noble, S. 2006. A practical approach to symptom management in palliative care. British Journal of Hospital Medicine 67(8), pp. 404-408. (10.12968/hmed.2006.67.8.21957)
- Noble, S. I. R. 2006. Acceptability of low molecular weight heparin thromboprophylaxis for inpatients receiving palliative care: qualitative study. British Medical Journal (BMJ) 332(7541), article number: 577. (10.1136/bmj.38733.616065.802)
Articles
- Ording, A. G. et al. 2024. Time toxicity of systemic anticancer therapy for metastatic lung cancer in routine clinical practice: A nationwide cohort study. JCO Oncology Practice (10.1200/op-24-00526)
- Edwards, M. et al. 2024. Involving patients and the public in cancer associated thrombosis research: a strategy for success.. Thrombosis Update, article number: 100196. (10.1016/j.tru.2024.100196)
- Martens, E. et al. 2024. Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis 245, article number: 109205. (10.1016/j.thromres.2024.109205)
- Ahmed, H., Davies, A., Daniel, R., Noble, S. and Farewell, D. 2024. Antibiotic prescribing patterns and risk of antibiotic-resistant infections and clostridium difficile in Warfarin and direct oral anticoagulant users: matched population-based cohort study. Discover Public Health 21(1), article number: 132. (10.1186/s12982-024-00263-1)
- Søgaard, M. et al. 2024. Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: A Danish nationwide cohort study. Journal of Thrombosis and Haemostasis (10.1016/j.jtha.2024.09.023)
- Ording, A. G. et al. 2024. Risk of venous thromboembolism in patients with stage III and IV non-small cell lung cancer: Nationwide descriptive cohort study. Clinical Lung Cancer 25(5), pp. 407-416. (10.1016/j.cllc.2024.04.004)
- Alikhan, R., Gomez, K., Maraveyas, A., Noble, S., Young, A. and Thomas, M. 2024. Cancer‐associated venous thrombosis in adults (second edition): A British Society for Haematology Guideline. British Journal of Haematology 205(1), pp. 71-87. (10.1111/bjh.19414)
- Nelson, A. et al. 2024. Chemotherapy decision-making in advanced lung cancer: a prospective qualitative study. BMJ Supportive & Palliative Care 14(1), pp. e758-e764. (10.1136/bmjspcare-2020-002395)
- Noble, S. 2024. Patient and public involvement in cancer-associated thrombosis research: necessary or glorified tokenism?. Bleeding, Thrombosis and Vascular Biology 3(s1) (10.4081/btvb.2024.125)
- Haire, E., Mann, M., Yeoman, A., Atkinson, C., Wright, M. and Noble, S. 2024. Supportive and palliative care needs in advanced non-malignant liver disease: systematic review. BMJ Supportive & Palliative Care (10.1136/spcare-2024-004785)
- Ahmed, H., Reeve, N., Farewell, D., Hamilton, F., Ponsford, M., Hippisley‐Cox, J. and Noble, S. 2024. Risk of bleeding amongst warfarin and direct oral anticoagulant users prescribed immediate antibiotics for respiratory tract infection: cohort study. Pharmacoepidemiology & Drug Safety 33(5), article number: e5794. (10.1002/pds.5794)
- Mørkved, A. L. et al. 2024. Risk and timing of venous thromboembolism after surgery for lung cancer: a nationwide cohort study. The Annals of Thoracic Surgery 117(2), pp. 289-296. (10.1016/j.athoracsur.2023.10.015)
- Ahmed, H., Davies, A., Daniel, R., Noble, S. and Farewell, D. 2024. Antibiotic prescribing patterns and risk of antibiotic-resistant infections and Clostridium difficile in Warfarin and Direct Oral Anticoagulant users: matched population-based cohort study. Discover Public Health 21(1), article number: 132. (10.1186/s12982-024-00263-1)
- Ording, A. G. et al. 2023. Risk of recurrent cancer-associated venous thromboembolism: A Danish nationwide cohort study. International Journal of Cardiology 390, article number: 131271. (10.1016/j.ijcard.2023.131271)
- Kitson, T. et al. 2023. HIDDEN2: Study protocol for the hospital deep vein thrombosis detection study in patients with cancer receiving palliative care. BMJ Open 13(9), article number: e073049. (10.1136/bmjopen-2023-073049)
- Goedegebuur, J. et al. 2023. Towards optimal use of antithrombotic therapy of people with cancer at the end of life: a research protocol for the development and implementation of the SERENITY shared decision support tool. Thrombosis Research 228, pp. 54-60. (10.1016/j.thromres.2023.05.008)
- Bravington, A. et al. 2023. Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction. PLoS ONE 18(8), article number: e0289501. (10.1371/journal.pone.0289501)
- Berman, R. et al. 2023. The rise of supportive oncology: a revolution in cancer care. Clinical Oncology 35(4), pp. 213-215. (10.1016/j.clon.2023.01.015)
- Crabtree, A. et al. 2023. Right needle, right patient, right time? A national flash-mob audit of thromboprophylaxis in palliative care. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis 223, pp. 95-101. (10.1016/j.thromres.2023.01.021)
- Barry, C., Paes, P., Noble, S. and Davies, A. 2023. Challenges to delivering evidence-based palliative medicine. Clinical Medicine 23(2), pp. 182-184. (10.7861/clinmed.2022-0336)
- Clare, W. et al. 2022. Hospice inpatient deep vein thrombosis detection (HIDDen) in advanced non-malignant diseases: a longitudinal pilot study. BMJ Supportive and Palliative Care 12(e6), pp. e767-e770. (10.1136/bmjspcare-2019-002039)
- Overvad, T. F., Skjøth, F., Piazza, G., Noble, S., Ording, A. G., Larsen, T. B. and Nielsen, P. B. 2022. The Khorana score and venous and arterial thrombosis in patients with cancer treated with immune checkpoint inhibitors: a Danish cohort study. Journal of Thrombosis and Haemostasis 20(12), pp. 2921-2929. (10.1111/jth.15883)
- Bravington, A. et al. 2022. The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: a systematic review. Palliative Medicine 36(9), pp. 1336-1350. (10.1177/02692163221122352)
- Dinnen, T. et al. 2022. Patient safety incidents in advance care planning for serious illness: a mixed-methods analysis. BMJ Supportive and Palliative Care 12(e3), pp. e403-e410. (10.1136/bmjspcare-2019-001824)
- Baddeley, E. et al. 2022. Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review. Palliative Medicine 36(6), pp. 895-911. (10.1177/02692163221081331)
- Seddon, K., Elliott, J., Johnson, M., White, C., Watson, M., Nelson, A. and Noble, S. 2022. Using the United Kingdom standards for public involvement to evaluate the impact of public involvement in a multinational clinical study. Research Involvement and Engagement 7(1), article number: 22. (10.1186/s40900-021-00264-3)
- Baddeley, E., Torrens-Burton, A., Newman, A., Nelson, A., Pease, N., Nelson, R. and Noble, S. 2021. A mixed-methods study to evaluate a patient-designed tool to reduce harm from cancer-associated thrombosis: The EMPOWER study. Research and Practice in Thrombosis and Haemostasis 5(5), article number: e12545. (10.1002/rth2.12545)
- Ording, A. G. et al. 2021. Increasing incidence and declining mortality after cancer-associated venous thromboembolism: a nationwide cohort study. American Journal of Medicine 134(7), pp. 868-876., article number: e5. (10.1016/j.amjmed.2021.01.031)
- Gleeson, A., Noble, S. and Mann, M. 2021. Advance care planning for home health staff: a systematic review. BMJ Supportive and Palliative Care 11(1), pp. 209-216. (10.1136/bmjspcare-2018-001680)
- Lyman, G. H. et al. 2021. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Advances 5(4), pp. 927-974. (10.1182/bloodadvances.2020003442)
- Højen, A. A., Søgaard, M., Seddon, K. and Noble, S. 2021. Patient public involvement and engagement in thrombosis research: not just for the intrepid. Research and Practice in Thrombosis and Haemostasis 5(1), pp. 245-246. (10.1002/rth2.12451)
- Ahmed, H., Whitaker, H., Farewell, D., Hippisley-Cox, J. and Noble, S. 2021. Respiratory tract infection and risk of bleeding in oral anticoagulant users: self-controlled case series. British Medical Journal 2021, article number: 375. (10.1136/bmj-2021-068037)
- Bennett, P., Noble, S., Johnston, S., Jones, D. and Hunter, R. 2020. Covid confessions: a qualitative exploration of health care workers experiences of working with covid-19. BMJ Open 10(12), article number: e043949. (10.1136/bmjopen-2020-043949)
- Schunemann, H. J. et al. 2020. Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis. Lancet Haematology 7(10), pp. e746-e755. (10.1016/S2352-3026(20)30293-3)
- Longo, M. et al. 2020. Holistic care: the clinical nurse specialist’s role in advanced lung cancer patients. Palliative Medicine 34(Supple), pp. 79-79. (10.1177/0269216320958098)
- Es, N. et al. 2020. The Khorana score for prediction of venous thromboembolism in cancer patients: An individual patient data meta-analysis. Journal of Thrombosis and Haemostasis 18(8), pp. 1940-1951. (10.1111/jth.14824)
- Baddeley, E. et al. 2020. Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study. BMJ Open 10(6), article number: e039154. (10.1136/bmjopen-2020-039154)
- Ventresca, M. et al. 2020. Obtaining and managing data sets for individual participant data meta-analysis: scoping review and practical guide. BMC Medical Research Methodology 20, article number: 113. (10.1186/s12874-020-00964-6)
- Noble, S., Nelson, A., Scott, J., Berger, A., Schmidt, K., Swarnkar, P. and Lee, A. 2020. Patient experience of living with cancer-associated thrombosis in Canada (PELICANADA). Research and Practice in Thrombosis and Haemostasis 4(1), pp. 154-160. (10.1002/rth2.12274)
- Watts, T., Willis, D., Noble, S. and Johnston, B. 2019. Death Rattle: reassuring harbinger of imminent death or a perfect example of inadequacies in evidence-based practice. Current Opinion in Supportive and Palliative Care 13(4), pp. 380-383. (10.1097/SPC.0000000000000463)
- Sivell, S. et al. 2019. Considerations and recommendations for conducting qualitative research interviews with palliative and end-of-life care patients in the home setting: a consensus paper. BMJ Supportive & Palliative Care 9, article number: e14. (10.1136/bmjspcare-2015-000892)
- Williams, H. et al. 2019. Quality improvement identifying priorities for safer out- of- hours palliative care: lessons from a mixed methods analysis of a national incident reporting database. Palliative Medicine 33(3), pp. 346-356. (10.1177/0269216318817692)
- White, C. et al. 2019. Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study. Lancet Haematology 6(2), pp. e79-e88. (10.1016/S2352-3026(18)30215-1)
- Noble, S. 2018. Patient relevant bleeding complications; it's bleeding complicated. Thrombosis Research 172, pp. 179-180. (10.1016/j.thromres.2018.10.032)
- Samuelson Bannow, B. R., Lee, A. Y. Y., Khorana, A. A., Zwicker, J. I., Noble, S., Ay, C. and Carrier, M. 2018. Management of anticoagulation for cancer-associated thrombosis in patients with thrombocytopenia: A systematic review. Research and Practice in Thrombosis and Haemostasis 2(4), pp. 664-669. (10.1002/rth2.12111)
- Harrop, E., Nelson, A., Rees, H., Harris, D. and Noble, S. 2018. The challenge pathway: a mixed methods evaluation of an innovative care model for the palliative and end-of-life care of people with dementia (innovative practice). Dementia 17(2), pp. 252-257. (10.1177/1471301217729532)
- Collins, J. T. et al. 2018. The value of physical performance measurements alongside assessment of sarcopenia in predicting receipt and completion of planned treatment in non-small cell lung cancer: an observational exploratory study. Supportive Care in Cancer 26, pp. 119-127. (10.1007/s00520-017-3821-6)
- Harrop, E., Noble, S., Edwards, M., Sivell, S., Moore, B. and Nelson, A. 2017. Managing, making sense of and finding meaning in advanced illness: a qualitative exploration of the coping and wellbeing experiences of patients with lung cancer. Sociology of Health & Illness 39(8), pp. 1448-1464.
- Bhatnagar, S., Gielen, J., Satija, A., Singh, S. P., Noble, S. and Chaturvedi, S. K. 2017. Signs of spiritual distress and its implications for practice in Indian palliative care. Indian Journal of Palliative Care 23(3), pp. 306-311. (10.4103/IJPC.IJPC_24_17)
- Anagnostou, D. et al. 2017. Development of an intervention to support patients and clinicians with advanced lung cancer when considering systematic anticancer therapy: protocol for the PACT study. BMJ Open 7(7), article number: e015277. (10.1136/bmjopen-2016-015277)
- Hunter, R., Lewis, S., Noble, S., Rance, J. and Bennett, P. D. 2017. "Post-thrombotic panic syndrome": a thematic analysis of the experience of venous thromboembolism. British Journal of Health Psychology 22(1), pp. 8-25. (10.1111/bjhp.12213)
- Noble, S. et al. 2016. Impact of a dedicated cancer-associated thrombosis service on clinical outcomes: a mixed-methods evaluation of a clinical improvement exercise. BMJ Open 6(11), article number: e013321. (10.1136/bmjopen-2016-013321)
- Noble, S. 2016. Thromboembolic disease and breathlessness. Current Opinion in Supportive and Palliative Care 10(3), pp. 249-255. (10.1097/SPC.0000000000000228)
- Mahé, I., Chidiac, J., Helfer, H. and Noble, S. 2016. Factors influencing adherence to clinical guidelines in the management of cancer-associated thrombosis. Journal of Thrombosis and Haemostatis 14(11), pp. 2107-2113. (10.1111/jth.13483)
- Harrop, E., Noble, S., Edwards, M., Sivell, S., Moore, B. and Nelson, A. 2016. 'I didn't really understand it, I just thought it'd help': exploring the motivations, understandings and experiences of patients with advanced lung cancer participating in a non-placebo clinical IMP trial. Trials 17(1), article number: 329. (10.1186/s13063-016-1460-8)
- Bennett, P., Patterson, K. and Noble, S. I. R. 2016. Predicting post-traumatic stress and health anxiety following a venous thrombotic embolism. Journal of Health Psychology 21(5), pp. 863-871. (10.1177/1359105314540965)
- Font, C., Garcia-Fernandez, T., Nelson, A., Prout, H. and Noble, S. 2016. Patients' Experiences of LIving with CANcer associated thrOmbosis in Spain (PELICANOS). Thrombosis Research 140(S1), pp. S199-S199. (10.1016/S0049-3848(16)30194-3)
- Schünemann, H. J. et al. 2016. Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol. BMJ Open 6(4), article number: e010569. (10.1136/bmjopen-2015-010569)
- Noble, S. and Sui, J. 2016. The treatment of cancer associated thrombosis: does one size fit all? Who should get LMWH/warfarin/DOACs?. Thrombosis Research 140(S1), pp. S154-S159. (10.1016/S0049-3848(16)30115-3)
- Macbeth, F. et al. 2016. Randomized phase III trial of standard therapy plus low molecular weight heparin in patients with lung cancer: FRAGMATIC trial. Journal of Clinical Oncology 34(5), pp. 488-494. (10.1200/JCO.2015.64.0268)
- Gielen, J., Bhatnagar, S., Noble, S. I. R. and Chaturvedi, S. K. 2016. Development and psychometric assessment of a spirituality questionnaire for Indian palliative care patients. Indian Journal of Palliative Care 22(1), pp. 9. (10.4103/0973-1075.173939)
- Noble, S. I. et al. 2015. A feasibility study to inform the design of a randomised controlled trial to identify the most clinically effective and cost-effective length of Anticoagulation with Low-molecular-weight heparin In the treatment of Cancer-Associated Thrombosis (ALICAT). Health Technology Assessment 19(83), pp. 1-94. (10.3310/hta19830)
- Noble, S. I. R. 2015. Palliation for haematological and solid tumours: what difference?. The Lancet Haematology 2(8), pp. e309-e310. (10.1016/S2352-3026(15)00128-3)
- Collins, J. et al. 2015. Association of sarcopenia and observed physical performance with attainment of multidisciplinary team planned treatment in non-small cell lung cancer: an observational study protocol. BMC Cancer 15, pp. 401-413., article number: 544. (10.1186/s12885-015-1565-6)
- Prout, H., Nelson, A. and Noble, S. 2015. The utility of PEmb-QoL and VEINES-QoL/Sym questionnaires in evaluating quality of life in the cancer associated thrombosis patient. Journal of Thrombosis and Haemostatis 13(S2), pp. 548., article number: PO109-TUE. (10.1111/jth.12993)
- Noble, S., Prout, H. and Nelson, A. 2015. Patients experiences of living with cancer associated thrombosis: the PELICAN study [Abstract]. Journal of Thrombosis and Haemostasis 13(S2), pp. 543-543. (10.1111/jth.12993)
- Davies, N. et al. 2015. Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thrombosis Research 135(6), pp. 1075-1080. (10.1016/j.thromres.2015.03.021)
- Noble, S., Prout, H. and Nelson, A. 2015. Patients' Experiences of LIving with CANcer-associated thrombosis: the PELICAN study. Patient Preference and Adherence 9, pp. 337-345. (10.2147/PPA.S79373)
- Watts, G. J., Nelson, A., Lester, J. S. and Noble, S. I. 2015. Quality of life measures relating to the skin toxicities of tyrosine kinase inhibitor (TKI) use in lung cancer what is in current use in the literature?. Lung Cancer 87(S1), pp. S33., article number: 84. (10.1016/S0169-5002(15)50083-4)
- Sivell, S. et al. 2015. Conducting qualitative research interviews with palliative and end of life care patients in the home setting: reflections and recommendations from an academic palliative care research centre [Conference Abstract]. BMJ Supportive and Palliative Care 5, article number: 117. (10.1136/bmjspcare-2014-000838.40)
- Mitchell, H., Noble, S. I. R., Finlay, I. G. and Nelson, A. 2015. Defining the palliative care patient: its challenges and implications for service delivery. BMJ Supportive & Palliative Care 5(4), pp. 46-52. (10.1136/bmjspcare-2012-000220rep)
- Prentice, J., Nelson, A., Baillie, J., Osborn, H. and Noble, S. I. R. 2014. 'Don't blame the middle man': an exploratory qualitative study to explore the experiences of translators breaking bad news. Journal of the Royal Society of Medicine 107(7), pp. 271-276. (10.1177/0141076814527275)
- Noble, S. et al. 2014. ALICAT: Anticoagulation length in cancer associated thrombosis - a mixed-methods feasibility study. Thrombosis Research 133(Supp 2), pp. S220-S220. (10.1016/S0049-3848(14)50032-1)
- Noble, S., Seaman, S. and Nelson, A. 2014. Attitudes of cancer associated thrombosis patients to the novel oral anticoagulants: insights from qualitative interviews. Thrombosis Research 133, pp. S219-S219.
- Noble, S., Lewis, R., Whithers, J., Lewis, S. and Bennett, P. 2014. Long-term psychological consequences of symptomatic pulmonary embolism: a qualitative study. BMJ Open 4(4), article number: e004561. (10.1136/bmjopen-2013-004561)
- Seaman, S., Nelson, A. and Noble, S. I. R. 2014. Is long-term low-molecular-weight heparin still acceptable to palliative care patients in the treatment of cancer-associated thrombosis? A qualitative study revisited. BMJ Supportive & Palliative Care 4, pp. A25., article number: P 028. (10.1136/bmjspcare-2014-000654.69)
- Carrier, M., Khorana, A. A., Zwicker, J. I., Noble, S. and Lee, A. Y. Y. 2014. Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH: a reply to a rebuttal. Journal of Thrombosis and Haemostatis 12(1), pp. 116-117. (10.1111/jth.12444)
- Collins, J., Noble, S. I. R., Chester, J. D., Coles, B. M. and Byrne, A. 2014. The assessment and impact of sarcopenia in lung cancer: a systematic literature review. BMJ Open 4(1), article number: e003697. (10.1136/bmjopen-2013-003697)
- Smith, J. D. et al. 2014. A feasibility study to inform the design of a randomized controlled trial to identify the most clinically and cost effective Anticoagulation Length with low molecular weight heparin In the treatment of Cancer Associated Thrombosis (ALICAT): study protocol for a mixed-methods study. Trials 15(1), article number: 122. (10.1186/1745-6215-15-122)
- Sheard, L., Prout, H., Dowding, D., Noble, S., Watt, I., Maraveyas, A. and Johnson, M. 2013. Barriers to the diagnosis and treatment of venous thromboembolism in advanced cancer patients: a qualitative study. Palliative Medicine 27(4), pp. 339-348.
- Johnson, M. J., Sheard, L., Maraveyas, A., Noble, S. I. R., Prout, H. C., Watt, I. and Dowding, D. 2012. Diagnosis and management of people with venous thromboembolism and advanced cancer: how do doctors decide? A qualitative study. BMC Medical Informatics and Decision Making 12(1), pp. 75-88. (10.1186/1472-6947-12-75)
- Smith, J. et al. 2012. Improving outcomes for palliative lung cancer patients: experience of a multiprofessional parallel clinic model in a district general hospital [Abstract]. Lung Cancer 75(Supp 1), pp. S32. (10.1016/S0169-5002(12)70098-3)
- Noble, S. I. R. et al. 2012. Addressing the lung cancer research agenda through user partnership working: the Stepping Stones experience. Lung Cancer 75(Supp 1), pp. S25. (10.1016/S0169-5002(12)70076-4)
- Howison, H. et al. 2012. A survey of patient attitudes to attending a lung cancer nurse specialist (LCNS) follow up clinic. Lung Cancer 75(Supp 1), pp. S32.
- Edwards, M. et al. 2012. 110 Motivations of palliative lung cancer patients to participate in a non-placebo clinical trial (QualFRAG). Lung Cancer 75(s1), pp. s36.
- Noble, S. I. R. 2012. Low-molecular-weight heparin and survival in lung cancer. Thrombosis Research 129(S1), pp. S114-S118. (10.1016/S0049-3848(12)70029-4)
- Gillon, S., Noble, S. I. R., Ward, J., Lodge, K., Nunn, A., Koon, S. and Johnson, M. 2011. Primary thromboprophylaxis for hospice inpatients: who needs it?. Palliative Medicine 25(7), pp. 701-705. (10.1177/0269216310397567)
- Harris, D. G., Flowers, S. and Noble, S. I. R. 2011. Nurses' views of the coping and support mechanisms experienced in managing terminal haemorrhage. International Journal of Palliative Nursing 17(1), pp. 7-13.
- Harris, D. G., Finlay, I. G., Flowers, S. and Noble, S. I. R. 2011. The use of crisis medication in the management of terminal haemorrhage due to incurable cancer: a qualitative study. Palliative Medicine 25(7), pp. 691-700. (10.1177/0269216311401464)
- Taubert, M., Noble, S. I. and Nelson, A. 2011. What challenges good palliative care provision out-of-hours? A qualitative interview study of out-of-hours general practitioners. BMJ Supportive & Palliative Care 1(1), pp. 13-18. (10.1136/bmjspcare-2011-000015)
- Noble, S. I. R. and Johnson, M. 2010. Finding the evidence for thromboprophylaxis in palliative care: first let us agree on the question [Editorial]. Palliative Medicine 24(4), pp. 359-361. (10.1177/0269216310366389)
- Smith, C. et al. 2010. Maximising recruitment to lung cancer trials, a single centre experience of the FRAGMATIC trial [Abstract]. Lung Cancer 67(s1), pp. S22. (10.1016/S0169-5002(10)70064-7)
- Maraveyas, A., Johnson, M. J., Xiao, Y. P. and Noble, S. I. R. 2010. Malignant melanoma as a target malignancy for the study of the anti-metastatic properties of the heparins. Cancer and Metastasis Reviews 29(4), pp. 777-784. (10.1007/s10555-010-9263-y)
- Noble, S. I. R. and Pasi, J. 2010. Epidemiology and pathophysiology of cancer-associated thrombosis. British Journal of Cancer 102, pp. S2-S9. (10.1038/sj.bjc.6605599)
- Stansby, G., Noble, S. I. R. and Howes, O. 2010. The importance of venous thromboembolism - a physical consequence of psychiatric treatments [Editorial]. International Journal of Clinical Practice 64(8), pp. 1005-1006. (10.1111/j.1742-1241.2010.02435.x)
- Noble, S. I. R., Parr, C., Yee, L. and Jiang, W. G. 2009. The effects of metastasis supressor-1 gene on the migratory properties of non small cell lung cancer [Abstract]. Lung Cancer 63(S1), pp. S3. (10.1016/S0169-5002(09)70007-8)
- Noble, S. I. R. and Jenkins, D. A. 2009. Management of venous thromboembolism in patients with cancer.. British Journal of Hospital Medicine 70(7), pp. 380-385.
- Macbeth, F. R., Griffiths, G. O., Noble, S. I. R., Burns, S. and Maughan, T. S. 2009. Interim safety data on the FRAGMATIC trial: a randomised phase III clinical trial investigating the effect of FRAGMin® added to standard therapy in patients with lung cancer [Abstract]. Journal of Thoraric Oncology 4(9), pp. S5-S968. (10.1097/JTO.0b013e3181b9c77e)
- Noble, S. I. R., Parr, C., Ye, L., Zhang, L. and Jiang, W. G. 2009. The impact of metastasis tumour supressor-1 (MTSS1) on the metastatic characteristics of non small cell lung cancer and its association with smoking history [Abstract]. Journal of Thoracic Oncology 4(9), pp. S630. (10.1097/JTO.0b013e3181b9c77e)
- Harris, D. G. and Noble, S. I. R. 2009. Management of terminal hemorrhage in patients with advanced cancer: a systematic literature review. Journal of Pain and Symptom Management 38(6), pp. 913-927. (10.1016/j.jpainsymman.2009.04.027)
- Griffiths, G. O., Burns, S., Noble, S. I. R., Macbeth, F. R., Cohen, D. and Maughan, T. S. 2009. Fragmatic: a randomised phase III clinical trial investigating the effect of fragmin® added to standard therapy in patients with lung cancer. BMC Cancer 9, pp. 355-363. (10.1186/1471-2407-9-355)
- Noble, S. I. R., Nelson, A. and Finlay, I. G. 2008. Factors influencing hospice thromboprophylaxis policy: a qualitative study. Palliative Medicine 22(7), pp. 808-813. (10.1177/0269216308096723)
- Rowlands, J. and Noble, S. I. R. 2008. How does the environment impact on the quality of life of advanced cancer patients? A qualitative study with implications for ward design. Palliative Medicine 22(6), pp. 768-774. (10.1177/0269216308093839)
- Noble, S. I. R., Nelson, A. and Finlay, I. G. 2008. Challenges faced by palliative care physicians when caring for doctors with advanced cancer. Palliative Medicine 22(1), pp. 71-76. (10.1177/0269216307084607)
- Noble, S. I. R., Shelley, M. D., Coles, B. M., Williams, S. M., Wilcock, A. and Johnson, M. J. 2008. Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis. The Lancet Oncology 9(6), pp. 577-584. (10.1016/S1470-2045(08)70149-9)
- Harris, D. and Noble, S. 2006. A practical approach to symptom management in palliative care. British Journal of Hospital Medicine 67(8), pp. 404-408. (10.12968/hmed.2006.67.8.21957)
- Noble, S. I. R. 2006. Acceptability of low molecular weight heparin thromboprophylaxis for inpatients receiving palliative care: qualitative study. British Medical Journal (BMJ) 332(7541), article number: 577. (10.1136/bmj.38733.616065.802)
Conferences
- Noble, S. I. R. et al. 2014. Anticoagulation length in cancer associated thrombosis: a mixed-methods feasibility study. Presented at: International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, Italy, 9-11 May 2014.
Research
I am involved in the following research projects and collaborations:
Research Assessment for Malignant Bowel Obstruction (RAMBO) (CI Noble S, Boland J). This is a collaboration with Hull York Medical School to develop a core outcome set for malignant bowel obstruction based on COMET methodology. Funded by Marie Curie.
Patient Experence of LIving with CANcer associted thrombosis (PELICAN) (CI Noble S). This International collaboration is a qualitative study to explore the commonalities and differences different healthcare systems and cultures have on the quality of life of cancer patients who have been diagnosed with venous thromboembolism. To date we have interveiwed 20 patients from each of the following countries: United Kingdom, France (PI Mahe I), Spain (PI Font C), Canada (PI Lee AYY), New Zealand (PI Woulfe T), Singapore (PI Yap ES).
Lung Cancer Bio Clot: (CI Evans P, Noble S). This work is a collaboration between the Haemostasis Biomedical Research Unit within the Welsh Centre for Emergency Medicine at Swansea University and the MCPCRC within the Division of Population Medicine. We are looking at changes in the clot microstructure of lng cancer patients receiving systemic anti cancer therapies with correlation to radiological outcomes. Funded by VElindre Stepping Stoones Charitable Funds.
Stopping Anticoagulation for isolated or incidental subsegmental pulmonary embolism (STOPAPE) (CI Lasserson) This NIHR multicentre study aims to recruit 1466 patients withisolated or incidental SSPE to explore whether the best management is to continue or stop anticoagulation at diagnosis. Co-ordinated through Warwick University. Funded by NIHR.
Biography
Committees and reviewing
“Quality of Life and Cancer Associated Thrombosis” Scandinavian Thrombosis Conference Online November 2020
“Cancer Associated Thrombosis at the End of Life”, Scandinavian Thrombosis Conference, Online November 2020
“Cancer Associated Thrombosis: what’s old and what’s new?” Nordic Conference on Thrombosis and Haemostasis, Billund, Denmark, September 2019
“The truth is out there: untangling the association of heparins with cancer survival” Multi-professional Association Supportive Care in Cancer (MASCC), San Francisco, USA, June 2019
“Update on venous thromboembolism at end of life”, Multi-professional Association Supportive Care in Cancer (MASCC), San Francisco, USA, June 2019
Contact Details
NobleSI1@cardiff.ac.uk
+44 29206 87245
Neuadd Meirionnydd, Room 6th Floor, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
+44 29206 87245
Neuadd Meirionnydd, Room 6th Floor, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS