Professor Sir Michael Owen
BSc, MB ChB, PhD, FRCPsych, FMedSci, FLSW
Professor, Division of Psychological Medicine and Clinical Neurosciences; Emeritus Director of the Neuroscience and Mental Health Innovation Institute
- OwenMJ@cardiff.ac.uk
- +44 29206 87062
- Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
- Media commentator
Overview
I am Professor of Psychological Medicine (Psychiatry) in the School of Medicine and Emeritus Director of the Neuroscience and Mental Health Research Institute.
I have worked on the genetics of psychiatric and neurodegenerative disorders for over 25 years have extensive research expertise in the genetic aspects of schizophrenia, bipolar disorder, Alzheimer's disease, depression and attention deficit hyperactivity disorder (ADHD). For the past 10 years, I have also worked on psychiatric and cognitive outcomes in children at high genetic risk, particularly those carrying structural chromosomal abnormalities.
I have studied the impact of genetic risk factors across diagnostic boundaries and developed a theoretical framework to understand the relationship between different neurodevelopmental disorders. I have has also identified specific genes and sets of proteins involved in the pathogenesis of schizophrenia and Alzheimer’s disease, which are potential therapeutic targets.
As well as continuing my work on psychiatric genetics, I am currently undertaking research aimed at translating recent genetic findings into a greater understanding of disease mechanisms and into the development of novel biomarkers to aid classification and diagnosis.
Publication
2024
- Legge, S. E. et al. 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 81, pp. 681-690. (10.1001/jamapsychiatry.2024.0200)
- Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)
- Owen, M. and O'Donovan, M. 2024. The genetics of cognition in schizophrenia.. Brain Medicine
- Hall, J. H. et al. 2024. Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs). Translational Psychiatry 14(1), article number: 259. (10.1038/s41398-024-02975-z)
- Stevenson-Hoare, J. et al. 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27(1), article number: e301097. (10.1136/bmjment-2024-301097)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14(1), article number: 256. (10.1038/s41398-024-02969-x)
- Cabezas De La Fuente, D. et al. 2024. Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a human stem cell model of neurodevelopmental disorder. Cell Reports 43(3), article number: 113946. (10.1016/j.celrep.2024.113946)
- Kopal, J. et al. 2024. Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 15(1), article number: 2639. (10.1038/s41467-024-46784-w)
- Kappel, D. et al. 2024. Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia. European Neuropsychopharmacology 80, pp. 47-54. (10.1016/j.euroneuro.2023.12.007)
- Tandon, R. et al. 2024. The schizophrenia syndrome, circa 2024: What we know and how that informs its nature. Schizophrenia Research 264, pp. 1-28. (10.1016/j.schres.2023.11.015)
- Doherty, J. L. et al. 2024. Atypical cortical networks in children at high-genetic risk of psychiatric and eurodevelopmental disorders. Neuropsychopharmacology 49, pp. 368-376. (10.1038/s41386-023-01628-x)
- Boen, R. et al. 2024. Beyond the global brain differences: Intra-individual variability differences in 1q21.1 distal and 15q11.2 BP1-BP2 deletion carriers. Biological Psychiatry 95(2), pp. 147-160. (10.1016/j.biopsych.2023.08.018)
- Peall, K. J., Owen, M. J. and Hall, J. 2024. Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes. Nature Reviews Neurology 20(1), pp. 7-21. (10.1038/s41582-023-00896-x)
- Ge, R. et al. 2024. Source‐based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome. Human Brain Mapping 45(1), article number: e26553. (10.1002/hbm.26553)
2023
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Chilvers, C. and Owen, M. J. 2023. Mental Health Research, shared goals. Journal of Mental Health 32, article number: 1017. (10.1080/09638237.2021.1898562)
- Caseras, X., Legge, S., Bracher-Smith, M., Anney, R., Owen, M., Escott-Price, V. and Kirov, G. 2023. Copy Number Variants increasing risk for schizophrenia: shared and distinct effects on brain morphometry and cognitive performance. Biological Psychiatry: Global Open Science 3(4), pp. 902-911. (10.1016/j.bpsgos.2022.10.006)
- Lock, S. K. et al. 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9, article number: 74. (10.1038/s41537-023-00404-6)
- Doherty, A., O'Donovan, M., Hamshere, M., Jones, I., Owen, M. and Walters, J. 2023. Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors. The American Journal of Psychiatry 180(10), pp. 723-738. (10.1176/appi.ajp.21121266)
- Owen, M., Legge, S., Rees, E., Walters, J. and O'Donovan, M. 2023. Genomic findings in schizophrenia and their implications. Molecular Psychiatry 28, pp. 3638-3647. (10.1038/s41380-023-02293-8)
- Kumar, K. et al. 2023. Subcortical brain alterations in carriers of genomic copy number variants. The American Journal of Psychiatry 180(9), pp. 685-698. (10.1176/appi.ajp.20220304)
- Le Guen, Y. et al. 2023. Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences 120(36), article number: e2302720120. (10.1073/pnas.2302720120)
- Ollà, I. et al. 2023. Pathogenic mis-splicing of CPEB4 in schizophrenia. Biological Psychiatry 94(4), pp. 341-351. (10.1016/j.biopsych.2023.03.010)
- Zhao, Y. et al. 2023. Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS. npj Genomic Medicine 8(1), article number: 17. (10.1038/s41525-023-00363-y)
- Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
- Kopal, J. et al. 2023. Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence. Nature Human Behaviour 7, pp. 1001-1007. (10.1038/s41562-023-01541-9)
- Chawner, S. J. et al. 2023. Neurodevelopmental dimensional assessment of young children at high genomic risk of neuropsychiatric conditions. JCPP Advances 3(2), article number: e12162. (10.1002/jcv2.12162)
- Niarchou, M. et al. 2023. Psychopathology in mothers of children with pathogenic copy number variants. Journal of Medical Genetics 60, pp. 706-711. (10.1136/jmg-2022-108752)
- Rogdaki, M. et al. 2023. Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study. Molecular Psychiatry 28, pp. 1995-2006. (10.1038/s41380-021-01108-y)
- Adams, R. L. et al. 2023. Psychopathology in adults with copy number variants. Psychological Medicine 53(7), pp. 3142-3149. (10.1017/S0033291721005201)
- Lin, J. et al. 2023. Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia. Molecular Psychiatry 28, pp. 2071-2080. (10.1038/s41380-023-02009-y)
- Chen, Z. et al. 2023. The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases. Neurobiology of Disease 180, article number: 106082. (10.1016/j.nbd.2023.106082)
- Moreau, C. A. et al. 2023. Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions. Brain 146(4), pp. 1686-1696. (10.1093/brain/awac315)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Pardinas, A. F. et al. 2023. Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data. The Lancet Psychiatry 10(3), pp. 209-219. (10.1016/S2215-0366(23)00002-0)
- Rammos, A., Kirov, G., Hubbard, L., Walters, J., Holmans, P., Owen, M. and Rees, E. 2023. Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia. Molecular Psychiatry 28, pp. 2081-2087. (10.1038/s41380-023-02013-2)
- Dimitriadis, S. I. et al. 2023. Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk. Cerebral Cortex 33(6), pp. 2997-3011. (10.1093/cercor/bhac256)
- Liu, D. et al. 2023. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics 55, pp. 369-376. (10.1038/s41588-023-01305-1)
- Owen, M. J. 2023. Genomic insights into schizophrenia. Royal Society Open Science 10(2), article number: 230125. (10.1098/rsos.230125)
- Moreau, C. A. et al. 2023. Genetic heterogeneity shapes brain connectivity in psychiatry. Biological Psychiatry 93(1), pp. 45-58. (10.1016/j.biopsych.2022.08.024)
- Kappel, D. B. et al. 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93, pp. 149-156. (10.1016/j.biopsych.2022.07.014)
- Wolstencroft, J. et al. 2023. Mental health impact of autism on families of children with intellectual and developmental disabilities of genetic origin. JCPP Advances, article number: e12128. (10.1002/jcv2.12128)
- Chawner, S. J. R. A., Evans, A., IMAGINE-ID consortium, ., Williams, N., Owen, M. J., Hall, J. and van den Bree, M. B. M. 2023. Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions. Translational Psychiatry 13, article number: 7. (10.1038/s41398-022-02296-z)
2022
- Owen, M. J. 2022. The contribution of the Rüdin school to psychiatric genetics: the light and the darkness. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders 48(Supple), pp. S1-S3. (10.1093/schbul/sbac119)
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12, article number: 438. (10.1038/s41398-022-02199-z)
- Woolway, G. et al. 2022. Schizophrenia polygenic risk and experiences of childhood adversity: a systematic review and meta-analysis. Schizophrenia Bulletin 48(5), pp. 967-980. (10.1093/schbul/sbac049)
- Chawner, S. and Owen, M. 2022. Autism: a model of neurodevelopmental diversity informed by genomics. Frontiers in Psychiatry 13, article number: 981691. (10.3389/fpsyt.2022.981691)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE, a UK national cohort study. The Lancet Psychiatry 9(9), pp. 715-724. (10.1016/S2215-0366(22)00207-3)
- Bracher-Smith, M. et al. 2022. Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK Biobank. Schizophrenia Research 246, pp. 156-164. (10.1016/j.schres.2022.06.006)
- Richards, A. et al. 2022. Genetic liabilities differentiating bipolar disorder, schizophrenia and major depression and phenotypic heterogeneity in bipolar disorder. JAMA Psychiatry 79(10), pp. 1032-1039. (10.1001/jamapsychiatry.2022.2594)
- Donnelly, N. A. et al. 2022. Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms. eLife 11, article number: e75482. (10.7554/elife.75482)
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79(10), pp. 963-970. (10.1001/jamapsychiatry.2022.2289)
- Fiksinski, A. M. et al. 2022. A normative chart for cognitive development in a genetically selected population. Neuropsychopharmacology 47(7), pp. 1379–1386. (10.1038/s41386-021-00988-6)
- Palmer, D. et al. 2022. Exome sequencing in bipolar disorder reveals AKAP11 as a risk gene shared with schizophrenia. Nature Genetics (10.1038/s41588-022-01034-x)
- Owen, M. and Legge, S. 2022. The nature of schizophrenia: as broad as it is long. Schizophrenia Research 242, pp. 109-112. (10.1016/j.schres.2021.10.012)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Singh, T., Schizophrenia Exome Meta-Analysis (SCHEMA) Consortium, ., Kirov, G., Rees, E., Walters, J., Owen, M. and O'Donovan, M. 2022. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature 604, pp. 509-516. (10.1038/s41586-022-04556-w)
- Cunningham, A. C., Hall, J., Owen, M. and van den Bree, M. B. M. 2022. Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs. Psychological Medicine 52(3), pp. 574-586. (10.1017/S0033291720002330)
- Chapman, G. et al. 2022. Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome. Molecular Psychiatry 27, pp. 819-830. (10.1038/s41380-021-01182-2)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE - The UK National Cohort Study. [Online]. papers.SSRN.com: Elsevier. (10.2139/ssrn.4028542) Available at: http://dx.doi.org/10.2139/ssrn.4028542
- Mullins, N. et al. 2022. Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors. Biological Psychiatry 91(3), pp. 313-327. (10.1016/j.biopsych.2021.05.029)
- Jones, H. J. et al. 2022. Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence. Psychological Medicine 52(1), pp. 132-139. (10.1017/S0033291720001798)
- Vassos, E. et al. 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48(1), pp. 20-26. (10.1093/schbul/sbab052)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
- Sanders, B. et al. 2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications 13(1), article number: 27. (10.1038/s41467-021-27601-0)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
2021
- Dimitriadis, S. I. et al. 2021. Global brain flexibility during working memory is reduced in a high genetic risk group for schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 6(12), pp. 1176-1184. (10.1016/j.bpsc.2021.01.007)
- Di Florio, A. et al. 2021. Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores. The Lancet Psychiatry 8(12), pp. 1045-1052. (10.1016/S2215-0366(21)00253-4)
- Kalman, J. L. et al. 2021. Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry 219(6), pp. 659-669. (10.1192/bjp.2021.102)
- Pardinas, A. F., Owen, M. J. and Walters, J. T. 2021. Pharmacogenomics: A road ahead for precision medicine in psychiatry. Neuron 109(24), pp. 3914-3929. (10.1016/j.neuron.2021.09.011)
- Dimitriadis, S. I. et al. 2021. Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk. Translational Psychiatry 11, article number: 592. (10.1038/s41398-021-01678-z)
- Jia, X. et al. 2021. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Molecular Psychiatry 26, pp. 5239-5250. (10.1038/s41380-020-01006-9)
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47(5), pp. 1375-1384. (10.1093/schbul/sbab036)
- Clifton, N. E. et al. 2021. Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry 90(6) (10.1016/j.biopsych.2021.03.009)
- Rees, E. et al. 2021. Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations. Nature Communications 12, article number: 5353. (10.1038/s41467-021-25532-4)
- Cleynen, I. et al. 2021. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Molecular Psychiatry, pp. 4496-4510. (10.1038/s41380-020-0654-3)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Clifton, N. E. et al. 2021. Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry 26, pp. 2977-2990. (10.1038/s41380-020-00912-2)
- Forsyth, J. K. et al. 2021. Prioritizing genetic contributors to cortical alterations in 22q11.2 deletion syndrome using imaging transcriptomics. Cerebral Cortex 31(7), pp. 3285-3298. (10.1093/cercor/bhab008)
- Modenato, C. et al. 2021. Effects of eight neuropsychiatric copy number variants on human brain structure. Translational Psychiatry 11(1), article number: 399. (10.1038/s41398-021-01490-9)
- Hubbard, L. et al. 2021. Rare copy number variations are associated with poorer cognition in schizophrenia. Biological Psychiatry 90(1), pp. 28-34. (10.1016/j.biopsych.2020.11.025)
- Byrne, E. et al. 2021. Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. Molecular Psychiatry 26, pp. 2070-2081. (10.1038/s41380-020-0705-9)
- Hall, L. S. et al. 2021. Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders. Molecular Psychiatry 26, pp. 2082-2088. (10.1038/s41380-020-0743-3)
- Amare, A. T. et al. 2021. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry 26, pp. 2457-2470. (10.1038/s41380-020-0689-5)
- Tigaret, C. M. et al. 2021. Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c. Molecular Psychiatry 26, pp. 1748-1760. (10.1038/s41380-020-01001-0)
- Mullins, N. et al. 2021. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics 53, pp. 817-829. (10.1038/s41588-021-00857-4)
- Owen, M. J. and Williams, N. M. 2021. Explaining the missing heritability of psychiatric disorders. World Psychiatry 20(2), pp. 294-295. (10.1002/wps.20870)
- Peterson, R. E. et al. 2021. Genome-wide analyses of smoking behaviors in schizophrenia: findings from the Psychiatric Genomics Consortium. Journal of Psychiatric Research 137, pp. 215-225. (10.1016/j.jpsychires.2021.02.027)
- Haan, N., Westacott, L. J., Carter, J., Owen, M. J., Gray, W. P., Hall, J. and Wilkinson, L. S. 2021. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational Psychiatry 11(1), article number: 313. (10.1038/s41398-021-01415-6)
- Willcocks, I. et al. 2021. Clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. Frontiers in Pharmacology 12, article number: 658734. (10.3389/fphar.2021.658734)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16(3), article number: e0249189. (10.1371/journal.pone.0249189)
- Linden, S. C. et al. 2021. The psychiatric phenotypes of 1q21 distal deletion and duplication. Translational Psychiatry 11, article number: 105. (10.1038/s41398-021-01226-9)
- Cunningham, A., Hall, J., Owen, M. and Van den Bree, M. 2021. Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants. Psychological Medicine 51(2), pp. 290-299. (10.1017/S0033291719003210)
- Owen, M. J. and O'Donovan, M. C. 2021. Large-scale genomics: a paradigm shift in psychiatry?. Biological Psychiatry 89, pp. 5-7. (10.1016/j.biopsych.2020.01.017)
- Chawner, S. et al. 2021. A genetics-first approach to dissecting the heterogeneity of autism: phenotypic comparison of autism risk copy number variants. American Journal of Psychiatry 178(1), pp. 77-86. (10.1176/appi.ajp.2020.20010015)
- Sønderby, I. E., Hall, J., Owen, M., Van Den Bree, M., Linden, D., Silva, A. and Doherty, J. 2021. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry 11, article number: 182. (10.1038/s41398-021-01213-0)
2020
- Davies, R. et al. 2020. Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 Deletion Syndrome. Nature Medicine 26, pp. 1912-1918. (10.1038/s41591-020-1103-1)
- Villalon-Reina, J. et al. 2020. Altered white matter microstructure in 22q11.2 deletion syndrome: a multi-site diffusion tensor imaging study. Molecular Psychiatry 25, pp. 2818-2831. (10.1038/s41380-019-0450-0)
- Kendall, K. M. et al. 2020. Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: a data linkage study. BJPsych Open 6(6), article number: e139. (10.1192/bjo.2020.42)
- Legge, S. E. et al. 2020. The Duffy-null genotype and risk of infection. Human Molecular Genetics 29(20), pp. 3341-3349. (10.1093/hmg/ddaa208)
- Jones, H. J. et al. 2020. A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 183(6), pp. 360-369. (10.1002/ajmg.b.32808)
- Dima, D. C. et al. 2020. Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk. Translational Psychiatry 10, article number: 324. (10.1038/s41398-020-00998-w)
- Sun, D. et al. 2020. Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry 25, pp. 1822-1834. (10.1038/s41380-018-0078-5)
- Coleman, J. R. I. et al. 2020. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry 25, pp. 1430-1446. (10.1038/s41380-019-0546-6)
- Cunningham, A., Fung, W., Massey, T., Hall, J., Owen, M., Van Den Bree, M. and Peall, K. 2020. Movement disorder phenotypes in children with 22q11.2 deletion syndrome. Movement Disorders 35(7), pp. 1272-1274. (10.1002/mds.28078)
- Akingbuwa, W. A. et al. 2020. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals. JAMA Psychiatry 77(7), pp. 715-728. (10.1001/jamapsychiatry.2020.0527)
- Ching, C. R. et al. 2020. Mapping subcortical brain alterations in 22q11.2 deletion syndrome: effects of seletion size and convergence with idiopathic neuropsychiatric illness. American Journal of Psychiatry 177(7), pp. 589-600. (10.1176/appi.ajp.2019.19060583)
- Lee, S. C. et al. 2020. Area deprivation, urbanicity, severe mental illness and social drift — a population-based linkage study using routinely collected primary and secondary care data. Schizophrenia Research 220, pp. 130-140. (10.1016/j.schres.2020.03.044)
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216(5), pp. 259-266. (10.1192/bjp.2019.120)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Moulding, H., Bartsch, U., Hall, J., Jones, M., Linden, D., Owen, M. and Van Den Bree, M. 2020. Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS). Psychological Medicine 50, pp. 1191-1202. (10.1017/S0033291719001119)
- Foley, C. et al. 2020. Identifying schizophrenia patients who carry pathogenic genetic copy number variants using standard clinical assessment: retrospective cohort study. British Journal of Psychiatry 216(5), pp. 275-279. (10.1192/bjp.2019.262)
- van der Meer, D. et al. 2020. Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA Psychiatry 77(4), pp. 420-430. (10.1001/jamapsychiatry.2019.3779)
- Rees, E. and Owen, M. J. 2020. Translating insights from neuropsychiatric genetics and genomics for precision psychiatry. Genome Medicine 12(1), article number: 43. (10.1186/s13073-020-00734-5)
- Eaton, C. B. et al. 2020. Response to letter to editor: 'Knowing when and how to use epilepsy screening questionnaires'. Epilepsia 61(4), pp. 826-827. (10.1111/epi.16463)
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2013
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2011
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2010
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2009
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2008
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2007
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2006
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2005
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2004
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2003
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2002
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2001
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- Rees, M. I., Lewis, T. M., Mortier, G., Snell, R. G., Schofield, P. R. and Owen, M. J. 2000. A transient hyperekplexia phenotype associated with compound heterozygote mutations in the human beta-subunit of the inhibitory glycine receptor (GLRB). American Journal of Human Genetics 67(4), pp. 391-391.
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- van Amelsvoort, T. et al. 2000. Brain abnormalities associated with deletions at 22q11: Implications for psychosis. Journal of Medical Genetics 37, pp. S26-S26.
- Williams, H., Murphy, K., Spurlock, G., O'Donovan, M. and Owen, M. 2000. No association of the -277A variant allele of the UFD1L promoter polymorphism and schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 533-534.
- Fitzpatrick, E., Spurlock, G., Coleman, S. L., Owen, M. J. and Buckland, P. R. 2000. Association studies of polymorphisms in the promoter region of the dopamine D4 receptor and the D2 receptor [Abstract]. American Journal of Medical Genetics 96(4), pp. 530-530. (10.1002/1096-8628(20000807)96:4<515::AID-AJMG6>3.0.CO;2-U)
- Van Amelsvoort, T. et al. 2000. Brain abnormalities associated with deletions at 22q11: Implicatons for psychosis. American Journal of Medical Genetics 96(4), pp. 551-551.
- Kirov, G., Stephens, M. and Owen, M. J. 2000. Examining the 4p16 region for association with bipolar disorder using DNA pooling. American Journal of Medical Genetics 96(4), pp. 548-548.
- Walters, S. E., Williams, N. M., Spurlock, G., Sanders, R. D., McCarthy, G. M., Cardno, A. G. and Owen, M. J. 2000. Identification of a polymorphism in the human NURR1 gene and investigation of an association with schizophrenia. American Journal of Medical Genetics 96(4), pp. 535-535.
- Payton, A. et al. 2000. A family based candidate gene association study of Attention Deficit Hyperactivity Disorder. American Journal of Medical Genetics 96(4), pp. 489-489.
- Murphy, K. C. and Owen, M. J. 2000. Evidence for association between polymorphisms of the catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) genes and schizophrenia in adults with velo-cardio-facial syndrome.. American Journal of Medical Genetics 96(4), pp. 476-476.
- Henry, J. C., van Amelsvoort, T., Morris, R. G., Owen, M. J., Murphy, K. C. and Murphy, D. G. M. 2000. The neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS).. American Journal of Medical Genetics 96(4), pp. 474-474.
- McCarthy, G. M. et al. 2000. Investigating familiality of subtypes in schizophrenia. American Journal of Medical Genetics 96(4), pp. 473-474.
- Bray, N. J., Jacobsen, N., Spurlock, G., Austin, J., Williams, H. and Owen, M. J. 2000. A functional and positional candidate gene for schizophrenia. American Journal of Medical Genetics 96(4), pp. 461-462.
- Elvidge, G. P., Owen, M. J. and Craddock, N. J. 2000. Mutational analysis of purinergic receptor, P2X4: A positional candidate susceptibility gene for bipolar disorder.. American Journal of Medical Genetics 96(4), pp. 493-493.
- Jacobsen, N. J., Franks, E. K., Craddock, N. J. and Owen, M. J. 2000. Genomic characterisation and mutational analysis of CUX2, a potential regulator of NCAM expression, mapping to chromosome 12q23-q24.1.. American Journal of Medical Genetics 96(4), pp. 493-494.
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10(2), pp. 83-86. (10.1097/00041444-200010020-00005)
- Jonsson, E. G., Norton, N., Gustavsson, J. P., Oreland, L., Owen, M. J. and Sedvall, G. C. 2000. A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Journal of Psychiatric Research 34(3), pp. 239-244. (10.1016/S0022-3956(00)00013-3)
- Deb, S., Braganza, J., Norton, N., Williams, H., Kehoe, P. G., Williams, J. and Owen, M. J. 2000. APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome. British Journal of Psychiatry 176, pp. 468-472. (10.1192/bjp.176.5.468)
- Middle, F. et al. 2000. Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene. American Journal of Medical Genetics 96(2), pp. 154-157. (10.1002/(sici)1096-8628(20000403)96:2%3C154::aid-ajmg5%3E3.0.co;2-f)
- Morris, D. W. et al. 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9(5), pp. 843-848. (10.1093/hmg/9.5.843)
- Owen, M. J. 2000. Molecular genetic studies of schizophrenia. Brain research. Brain research reviews 31(2-3), pp. 179-186. (10.1016/S0165-0173(99)00035-1)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Bowen, T. et al. 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10(1), pp. 33-37. (10.1097/00041444-200010010-00006)
- Farmer, A. E., Owen, M. J. and McGuffin, P. 2000. Bioethics and genetic research in psychiatry. British Journal of Psychiatry 176, pp. 105-108. (10.1192/bjp.176.2.105)
- Rees, M. I., Watts, P., Fenton, I., Clarke, A., Snell, R. G., Owen, M. J. and Gray, J. 2000. Further evidence of autosomal dominant congenital zonular pulverulent cataracts linked to 13q11 (CZP3) and a novel mutation in connexin 46 (GJA3).. Human Genetics 106(2), pp. 206-209. (10.1007/s004390051029)
- Tunstall, N. et al. 2000. Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease. British Journal of Psychiatry 176, pp. 156-159. (10.1192/bjp.176.2.156)
- Buckland, J., Pennington, D. J., Bruno, L. and Owen, M. J. 2000. Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development. European Journal of Immunology 30(1), pp. 8-18. (10.1002/1521-4141(200001)30:1<8::AID-IMMU8>3.0.CO;2-8)
- Owen, M. J., Cardno, A. G. and O'Donovan, M. C. 2000. Psychiatric genetics: back to the future. Molecular Psychiatry 5(1), pp. 22-31. (10.1038/sj.mp.4000702)
- Kirov, G., Stephens, M., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2000. Automated genotyping of single-nucleotide polymorphisms by extension of fluorescently labelled primers: analysis of individual and pooled DNA samples. Balkan Journal of Medical Genetics 3, pp. 23-28.
- Cardno, A. G., O'Donovan, M. C. and Owen, M. J. 2000. Genetic risk factors for schizophrenia. International Journal of Mental Health 29(3), pp. 13-38.
- Deb, S., Braganza, J., Norton, N., Williams, H., Kehoe, P. G., Williams, J. and Owen, M. J. 2000. Presence of the Apolipoprotein E e4 allele is associated with the manifestation of Alzheimer dementia in adults with Down syndrome. Journal of Intellectual Disability Research 44, pp. 259-259.
- Murphy, K. and Owen, M. J. 2000. No association between polymorphisms of catechol-o-methyltransferase (COMT) or monoamine oxidase (MAO) genes and schizophrenia in adults with velo-cardio-facial syndrome. Schizophrenia Research 41(1), pp. 96. (10.1016/S0920-9964(00)90531-0)
- Murphy, K., Jones, L. and Owen, M. J. 2000. High rates of schizophrenia in adults with velo-cardio-facial syndrome (VCFS). Schizophrenia Research 41(1), pp. 29-29. (10.1016/S0920-9964(00)90364-5)
- Kirov, G., Williams, N. M., Sham, P., Craddock, N. J. and Owen, M. J. 2000. Pooled genotyping of microsatellite markers in parent-offspring trios. Genome Research 10(1), pp. 105-115.
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- Watts, P., Rees, M. I., Clarke, A. J., Beck, L., Lane, C. M., Owen, M. J. and Gray, J. 2000. Linkage analysis in an autosomal dominant 'zonular nuclear pulverulent' congenital cataract, mapped to chromosome 13q11-13. Eye 14(2), pp. 172-175. (10.1038/eye.2000.48)
- Williams, N. et al. 2000. Identification and characterisation of SNPs in candidate genes for schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 462.
- Williams, N. et al. 2000. Linkage disequilibrium mapping and candidate gene screening of the VCFS deleted region for mutations associated with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 475.
1999
- Kirov, G., Norton, N., Jones, I. R., McCandless, F., Craddock, N. J. and Owen, M. J. 1999. A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder. International Journal of Neuropsychopharmacology 2(4), pp. 293-298. (10.1017/s1461145799001601)
- Kirov, G., Jones, I. R., McCandless, F., Craddock, N. J. and Owen, M. J. 1999. Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5. Molecular Psychiatry 4(6), pp. 558-565.
- Willliams, H., Bray, N. J., Murphy, K. C., Cardno, A. G., Jones, L. A. and Owen, M. J. 1999. No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).. American Journal Of Medical Genetics Part A 88(5), pp. 557-559. (10.1002/(SICI)1096-8628(19991015)88:5<557::AID-AJMG22>3.0.CO;2-F)
- Murphy, K. C., Jones, L. A. and Owen, M. J. 1999. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Archives of General Psychiatry 56(10), pp. 940-945. (10.1001/archpsyc.56.10.940)
- Kirov, G. and Owen, M. J. 1999. Identification of new microsatellite markers on chromosome 4p16. American Journal of Human Genetics 65(4), pp. A257-A257.
- Murphy, K. C., Jones, L. A. and Owen, M. J. 1999. High rates of schizophrenia in velo-cardio-facial syndrome. American Journal of Human Genetics 65(4), pp. A336-A336.
- Bowen, T. et al. 1999. Linkage studies of bipolar disorder with chromosome 18 markers. American Journal of Medical Genetics 15(88), pp. 503-509. (10.1002/(SICI)1096-8628(19991015)88:5<503::AID-AJMG13>3.0.CO;2-U)
- Williams, N. M. et al. 1999. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Human Molecular Genetics 8(9), pp. 1729-1739. (10.1093/hmg/8.9.1729)
- O'Donovan, M. C. and Owen, M. J. 1999. Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65(3), pp. 587-592. (10.1086/302560)
- McCarthy, G. et al. 1999. Intra-pair correlations of symptom dimensions in a sibling pair study of schizophrenia. Molecular Psychiatry 4, pp. S26-S27.
- Fisher, P. J. et al. 1999. A high resolution genome scan made possible with DNA pooling. Molecular Psychiatry 4(1), pp. S10-S10.
- Owen, M. J. 1999. Evidence of novel loci in late onset Alzheimer's disease. Molecular Psychiatry 4(1), pp. S9-S9.
- Murphy, K. C. and Owen, M. J. 1999. No association between polymorphisms of catechol-O-methyltransferase (COMT) or monoamine oxidase (MAO) genes and schizophrenia in adults with velo-cardio-facial syndrome. Journal of Medical Genetics 36, pp. S78-S78.
- Murphy, K., Thompson, P. W., Davies, S. J., Groves, P., Owen, M. J. and Stuart, G. 1999. The prevalence of chromosome 22q11 deletions in an adult congenital heart disease population. Journal of Medical Genetics 36, pp. S59-S59.
- Jones, L. A., Sanders, R. D., Cardno, A. G., Owen, M. J. and Williams, J. 1999. Sustained and selective attention as quantitative measures of schizophrenia liability. Molecular Psychiatry 4, pp. S117-S117.
- Emilien, G., Maloteaux, J., Geurts, M. and Owen, M. J. 1999. Dopamine receptors and schizophrenia: contribution of molecular genetics and clinical neuropsychology. The International Journal of Neuropsychopharmacology 2(3), pp. 197. (10.1017/S1461145799001479)
- Williams, H. J. et al. 1999. Characterization, mutational analysis, and association of the human proline oxidase gene: A candidate gene for schizophrenia.. Molecular Psychiatry 4, pp. S115-S115.
- Sanders, R. D., Norton, N., Williams, J. and Owen, M. J. 1999. Pre-pulse inhibition in the functional psychoses. Molecular Psychiatry 4, pp. S121-S121.
- Hill, L. et al. 1999. IGF2R and cognitive ability. Molecular Psychiatry 4, pp. S108-S108.
- Jonsson, E. G., Norton, N., Gustavsson, J. P., Oreland, L., Owen, M. J. and Sedvall, G. C. 1999. Monoamine oxidase a promoter polymorphism and relationships to monoamine metabolite concentrations in CSF. Molecular Psychiatry 4, pp. S97-S98.
- Norton, N. et al. 1999. No evidence for association between schizophrenia and MAO-A promoter polymorphism. Molecular Psychiatry 4, pp. S96-S96.
- Middle, F. A. et al. 1999. Association studies between bipolar disorder and a polymorphism in the Wolfram gene. Molecular Psychiatry 4, pp. S76-S76.
- Jones, I. R., Owen, M. J. and Craddock, N. J. 1999. Further evidence of familial cosegregation of major affective disorder and Darier's disease. Molecular Psychiatry 4, pp. S73-S73.
- Thapar, A. et al. 1999. A quantitative trait loci study of attention deficit hyperactivity disorder. Molecular Psychiatry 4, pp. S52-S53.
- McCarthy, G. et al. 1999. Familial aggregation of clinical variables in a sibling pair study of schizophrenia. Molecular Psychiatry 4, pp. S121-S121.
- Bray, N. J., Cardno, A. G., Fitzpatrick, E. R., Buckland, P. R. and Owen, M. J. 1999. Embryonic NCAM and schizophrenia: Genetic analysis of regulatory enzymes. Molecular Psychiatry 4, pp. S32-S32.
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Kirov, G., Rees, M., Jones, I. R., McCandless, F., Owen, M. J. and Craddock, N. J. 1999. Bipolar disorder and the serotonin transporter gene: a family-based association study. Psychological Medicine -London- 29(5), pp. 1249-1254. (10.1017/s003329179900882x)
- Williams, N. M., Bowen, T., Kirov, G., Williams, H., Hoogendorn, B., Asherson, P. and Owen, M. J. 1999. Polymorphism screening and association studies of the Wolfram syndrome gene in schizophrenia. Molecular Psychiatry 4(supp1), pp. S42-S42.
- Guy, C., Bowen, T., Jones, I. R., McCandless, F., Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 1999. CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder. Neurobiology of Disease 6(4), pp. 302-307. (10.1006/nbdi.1999.0249)
- Wavrant-De Vrieze, F. et al. 1999. Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease. Neuroscience Letters 269(2), pp. 67-70.
- Owen, M. J. and Cardno, A. G. 1999. Psychiatric genetics: progress, problems, and potential. The Lancet 354(1), pp. SI11-SI14. (10.1016/S0140-6736(99)90242-8)
- Rees, M. I. et al. 1999. Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry 4(4), pp. 353-359. (10.1038/sj.mp.4000521)
- Cardno, A. G. et al. 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45(12), pp. 1592-1596. (10.1016/s0006-3223(99)00033-5)
- Williams, J., Kehoe, P. G. and Owen, M. J. 1999. Case-control study of presenelin-1 intronic polymorphism. Journal of Neurology, Neurosurgery & Psychiatry 66(6), pp. 702. (10.1136/jnnp.66.6.702)
- Fisher, P. J. et al. 1999. DNA pooling identifies QTLs on chromosome 4 for general cognitive ability in children. Human Molecular Genetics 8(5), pp. 915-922. (10.1093/hmg/8.5.915)
- Jacobsen, N. J., Franks, E. K., Owen, M. J. and Craddock, N. J. 1999. Mutational analysis of phospholipase A2A: a positional candidate susceptibility gene for bipolar disorder. Molecular Psychiatry 4(3), pp. 274-279. (10.1038/sj.mp.4000476)
- Amelsvoort, T. V. et al. 1999. An MRI and fMRI study on the effect of deletions on chromosome 22 on brain. Biological psychiatry 45(8), pp. 110S-111S.
- Hill, L. et al. 1999. DNA pooling and dense marker maps: a systematic search for genes for cognitive ability. NeuroReport 10(4), pp. 843-848. (10.1097/00001756-199903170-00032)
- Wavrant-DeVrieze, F. et al. 1999. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters 262(2), pp. 137-139. (10.1016/S0304-3940(99)00035-X)
- Sakuntabhai, A. et al. 1999. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nature Genetics 21(3), pp. 271-277.
- Franks, E., Guy, C., Jacobsen, N., Bowen, T., Owen, M. J., O'Donovan, M. C. and Craddock, N. J. 1999. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics 88(1), pp. 67-70. (10.1002/(SICI)1096-8628(19990205)88:1<67::AID-AJMG12>3.0.CO;2-#)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88(1), pp. 57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Kehoe, P. et al. 1999. A full genome scan for late onset Alzheimer's disease. Human Molecular Genetics 8(2), pp. 237-245. (10.1093/hmg/8.2.237)
- Kehoe, P., Krawczak, M., Harper, P. S., Owen, M. J. and Jones, L. 1999. Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length. Journal of Medical Genetics 36(2), pp. 108-111. (10.1136/jmg.36.2.108)
- Kehoe, P. G. et al. 1999. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nature Genetics 21(1), pp. 71-72. (10.1038/5009)
- Kerwin, R. and Owen, M. J. 1999. Genetics of novel therapeutic targets in schizophrenia. The British journal of psychiatry. Supplement. 38, pp. 1-4.
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
- Cardno, A. G., Jones, L. A., Murphy, K. C., Sanders, R. D., Asherson, P., Owen, M. J. and McGuffin, P. 1999. Dimensions of psychosis in affected sibling pairs. Schizophrenia Bulletin 25(4), pp. 841-850.
- Kirov, G., Owen, M. J., Jones, I., McCandless, F. and Craddock, N. J. 1999. Tryptophan hydroxylase gene and manic-depressive illness [letter]. Archives of General Psychiatry 56(1), pp. 98-99. (10.1001/archpsyc.56.1.98)
1998
- Kehoe, P. G., Williams, H., Holmans, P. A., Wilcock, G., Cairns, N. J., Neal, J. and Owen, M. J. 1998. The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. Journal of Medical Genetics 35(12), pp. 1034-1035. (10.1136/jmg.35.12.1034)
- Spurlock, G., Williams, N. M., Williams, H. and Owen, M. J. 1998. Polymorphism screening of the human type 1 sigma (sigma) receptor (a candidate gene for schizophrenia) using a modified dideoxy fingerprinting technique.. American Journal of Medical Genetics 81(6), pp. 525-526.
- Poulton, K. et al. 1998. A molecular genetic study of hyperkinetic disorder/attention deficit hyperactivity disorder. American Journal of Medical Genetics 81(6), pp. 458-458.
- Williams, N. M., Fenton, I. and Owen, M. J. 1998. PsycheMap - An interactive Internet-based database of psychiatric genetics linkage, association, and genome mapping projects. American Journal of Medical Genetics 81(6), pp. 463-464.
- Fisher, P. J. et al. 1998. DNA pooling for genomic scanning - Application to an association study. American Journal of Medical Genetics 81(6), pp. 469-469.
- Kirov, G., Jones, I. R., McCandless, F., Craddock, N. J. and Owen, M. J. 1998. Family-based association studies of candidate genes in bipolar disorder. American Journal of Medical Genetics 81(6), pp. 476-477.
- Williams, N. M., Kirov, G., Craddock, N. J. and Owen, M. J. 1998. Screening the critical region on chromosome 4p with DNA pooling for association with bipolar disorder. American Journal of Medical Genetics 81(6), pp. 486-486.
- Bennett, P., Mulcahy, T., Owen, M. J., Craddock, N. J. and Gill, M. 1998. The Wellcome Trust UK-Irish Bipolar Sib-pair Study: Chromosome 21. American Journal of Medical Genetics 81(6), pp. 541-541.
- Hill, L. et al. 1998. QTLs for general cognitive ability in children: DNA pooling for chromosome 22. American Journal of Medical Genetics 81(6), pp. 486-486.
- Spurlock, G., Williams, N., Williams, H. and Owen, M. 1998. Polymorphism screening of the human type 1 Sigma (σ) receptor (a candidate gene for schizophrenia) using a modified dideoxy fingerprinting technique. American Journal of Medical Genetics - Neuropsychiatric Genetics 81(6), pp. 525-526.
- Deb, S., Braganza, J., Owen, M. J., Kehoe, P., Williams, H. and Norton, N. 1998. No significant association between a PS-1 intronic polymorphism and dementia in Down's syndrome. Alzheimers Reports 1(6), pp. 365-368.
- Murphy, K. C. and Owen, M. J. 1998. Chromosome 22qII deletions and aggressive behaviour. British Journal of Psychiatry 173, pp. 353-354. (10.1192/bjp.173.4.353b)
- Wu, W. S. et al. 1998. Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA - The Journal of the American Medical Association 280(7), pp. 619-622. (10.1001/jama.280.7.619)
- Straub, R. E. et al. 1998. A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further support for a susceptibility locus for schizophrenia at 22q12. Schizophrenia Collaborative Linkage Group for Chromosome 22. Schizophrenia Research 32(2), pp. 115-121. (10.1016/S0920-9964(98)00048-6)
- Wright, P. et al. 1998. A transmission/disequilibrium study of the DRB1*04 gene locus on chromosome 6p21.3 with schizophrenia. Schizophrenia Research 32(2), pp. 75-80. (10.1016/S0920-9964(98)00050-4)
- Cardno, A. G., Jones, L. A., Murphy, K. C., Sanders, R. D., Asherson, P., Owen, M. J. and McGuffin, P. 1998. Sibling pairs with schizophrenia or schizoaffective disorder: associations of subtypes, symptoms and demographic variables. Psychological Medicine 28(4), pp. 815-823. (10.1017/S0033291798006783)
- Owen, M. J. and Craddock, N. J. 1998. Chromosome 11 workshop. Psychiatric Genetics 8(2), pp. 89-92.
- Owen, M. J. and McGuffin, P. 1998. The programmed alliance of two disciplines. La Recherche 311, pp. 38-39.
- Asherson, P. et al. 1998. A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder. Molecular Psychiatry 3(4), pp. 310-320. (10.1038/sj.mp.4000399)
- Kirov, G. et al. 1998. Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder. Molecular Psychiatry 3(4), pp. 342-345. (10.1038/sj.mp.4000385)
- Daniels, J., Holmans, P. A., Williams, N. M., Turic, D., McGuffin, P., Plomin, R. and Owen, M. J. 1998. A simple method for analyzing microsatellite allele image patterns generated from DNA pools and its application to allelic association studies. American Journal of Human Genetics 62(5), pp. 1189-1197. (10.1086/301816)
- Chorney, M. et al. 1998. A Quantitative Trait Locus Associated With Cognitive Ability in Children. Psychological Science 9(3), pp. 159-166. (10.1111/1467-9280.00032)
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1997
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1996
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1995
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1994
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1993
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- Saudino, K. J. et al. 1993. Applying a QTL association approach to temperament. Behavior Genetics 23(6), pp. 564-564.
- Asherson, P. et al. 1993. Failure to find linkage between schizophrenia and genetic markers on chromosome 21. American Journal of Medical Genetics 48(3), pp. 161-165. (10.1002/ajmg.1320480310)
- Mant, R., Williams, J., Asherson, P., Parfitt, E., McGuffin, P. and Owen, M. J. 1993. Susceptibility to schizophrenia and the dopamine d3 receptor gene. American Journal of Human Genetics 53(3), pp. 1654-1654.
- Owen, M. J. and McGuffin, P. 1993. Association and linkage: complementary strategies for complex disorders.. Journal of Medical Genetics 30(8), pp. 638-639. (10.1136/jmg.30.8.638)
- Shaikh, S. et al. 1993. The dopamine D3 receptor gene: no association with bipolar affective disorder. Journal of Medical Genetics 30(4), pp. 308-309. (10.1136/jmg.30.4.308)
- Gill, M. et al. 1993. A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychological Medicine 23(1), pp. 27-44. (10.1017/S0033291700038824)
- Jones, P. B., Owen, M. J., Lewis, S. W. and Murray, R. M. 1993. A case-control study of family history and cerebral cortical abnormalities in schizophrenia. Acta Psychiatrica Scandinavica 87(1), pp. 6-12. (10.1111/j.1600-0447.1993.tb03322.x)
- Craddock, N. J., Burge, S., Parfitt, L. and Owen, M. J. 1993. Linkage is excluded between Darier's disease and the Duffy blood group locus in five British families. Annales de Genetique 36(4), pp. 211-213.
1992
- Owen, M. J. and Liddell, M. 1992. Role of amyloid beta-protein in Alzheimer's disease. The Lancet 340(8823), pp. 851-851.
- Owen, M. J. and McGuffin, P. 1992. The molecular genetics of schizophrenia.. British Medical Journal (BMJ) 305(6855), pp. 664-665. (10.1136/bmj.305.6855.664)
- Mant, R., Asherson, P., Gill, M., McGuffin, P. and Owen, M. J. 1992. Schizophrenia scepticism. Nature Genetics 2(1), pp. 12-12. (10.1038/ng0992-12)
- Owen, M. J. et al. 1992. No association between RFLPs at the porphobilinogen deaminase gene and schizophrenia. Human Genetics 90(1-2), pp. 131-132. (10.1007/BF00210756)
- Vallada, H., Collier, D., Dawson, E., Owen, M. J., Nanko, S., Murray, R. and Gill, M. 1992. Debrisoquine 4-hydroxylase (CYP2D) locus and possible susceptibility to schizophrenia. The Lancet 340(8812), pp. 181-182. (10.1016/0140-6736(92)93266-P)
- Asherson, P. et al. 1992. No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families. British Journal of Psychiatry 161(1), pp. 63-68. (10.1192/bjp.161.1.63)
- O'Donovan, M. C. and Owen, M. J. 1992. Advances and Retreats in the Molecular Genetics of Major Mental Illness. Annals of Medicine 24(3), pp. 171-177. (10.3109/07853899209147816)
- Craddock, N. J. and Owen, M. J. 1992. Christmas disease and major affective disorder [letter]. British Journal of Psychiatry 160, pp. 715-715. (10.1192/bjp.160.5.715a)
- Nanko, S., Gill, M., Owen, M. J., Takazawa, N., Moridaira, J. and Kazamatsuri, H. 1992. Linkage Study of Schizophrenia with Markers on Chromosome 11 in Two Japanese Pedigrees. Psychiatry and Clinical Neurosciences 46(1), pp. 155-159. (10.1111/j.1440-1819.1992.tb00828.x)
- Shaikh, S., Owen, M. J. and Gill, M. 1992. DRD2 (TGn) repeat polymorphism in a large family data set. Schizophrenia Research 6(2), pp. 91-91. (10.1016/0920-9964(92)90088-M)
- Dawson, E. et al. 1992. Genetic linkage analysis of schizophrenia using microsatellite repeat polymorphisms on chromosome 12. Schizophrenia Research 6(2), pp. 90-90. (10.1016/0920-9964(92)90086-K)
- Collier, D., Gill, M., Nanko, S., Owen, M. J. and Vallada, H. 1992. Linkage analysis of schizophrenia on chromosome 22. Schizophrenia Research 6(2), pp. 89-90. (10.1016/0920-9964(92)90085-J)
- Owen, M. J. and GILL, M. 1992. Looking for genes in schizophrenia. Clinical Neuropharmacology 15(Suppl1), pp. 222A-223A. (10.1097/00002826-199201001-00116)
1991
- Upadhyaya, M., Lunt, P. W., Sarfarazi, M., Broadhead, W., Daniels, J., Owen, M. J. and Harper, P. S. 1991. A closely linked DNA marker for facioscapulohumeral disease on chromosome 4q.. Journal of Medical Genetics 28(10), pp. 665-671. (10.1136/jmg.28.10.665)
- Owen, M. J. et al. 1991. Linkage studies of schizophrenia with markers of chromosome-11q. American Journal of Human Genetics 49(4), pp. 354-354.
- Mant, R., Parfitt, E., Hardy, J. and Owen, M. J. 1991. Mononucleotide repeat polymorphism in the APP gene. Nucleic Acids Research 19(16), pp. 4572-4572. (10.1093/nar/19.16.4572-a)
- Owen, M. J., Goate, A. and Hardy, J. 1991. A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80). Nucleic Acids Research 19(16), pp. 4574-4571. (10.1093/nar/19.16.4574)
- Foerster, A., Lewis, S. W., Owen, M. J. and Murray, R. M. 1991. Low birth weight and a family history of schizophrenia predict poor premorbid functioning in psychosis. Schizophrenia Research 5(1), pp. 13-20. (10.1016/0920-9964(91)90049-W)
- Goate, A. et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349(6311), pp. 704-706. (10.1038/349704a0)
- Foerster, A., Lewis, S., Owen, M. J. and Murray, R. 1991. Pre-morbid adjustment and personality in psychosis. Effects of sex and diagnosis. British Journal of Psychiatry 158(2), pp. 171-176. (10.1192/bjp.158.2.171)
- Owen, M. J. and McGuffin, P. 1991. DNA-and classical genetic markers in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 240(3), pp. 197-203. (10.1007/BF02190764)
- McGuffin, P. and Owen, M. J. 1991. The molecular genetics of schizophrenia: An overview and forward view. European Archives of Psychiatry and Clinical Neuroscience 240(3), pp. 169-173. (10.1007/BF02190759)
- Mant, R. et al. 1991. Exclusion of close linkage between GABA a receptor subunit 1a gene and schizophrenia using a microsatellite repeat marker. Cytogenetics and Cell Genetics 58(3-4), pp. 1900-1991.
1990
- Upadhyaya, M., Lunt, P., Sarfarazi, M., Broadhead, W., Daniels, J., Owen, M. J. and Harper, P. 1990. DNA marker applicable to presymptomatic and prenatal diagnosis of facioscapulohumeral disease. The Lancet 336(8726), pp. 1320-1321. (10.1016/0140-6736(90)93005-A)
- St George-Hyslop, P. H. et al. 1990. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 347(6289), pp. 194-197. (10.1038/347194a0)
- Owen, M. J., McGuffin, P. and Andrews, R. 1990. Obstetric complications and schizophrenia. The Lancet 336(8707), pp. 122-122. (10.1016/0140-6736(90)91643-O)
- Owen, M. J., Craufurd, D. and St Clair, D. 1990. Localisation of a susceptibility locus for schizophrenia on chromosome 5. British Journal of Psychiatry 157(1), pp. 123-127. (10.1192/bjp.157.1.123)
- Owen, M. J., James, L., Hardy, J., Williamson, R. and Goate, A. 1990. Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.. American Journal of Human Genetics 46(2), pp. 316-322.
- Owen, M. J. and Mullan, M. J. 1990. Molecular genetic studies of manic-depression and schizophrenia. Trends in Neurosciences 13(1), pp. 29-31. (10.1016/0166-2236(90)90059-J)
- Goate, A. et al. 1990. Genetics of Alzheimer's disease. Advances in Neurology -New York- Raven Press- 51, pp. 197-198.
1989
- Hardy, J., Goate, A., Owen, M. J. and Rossor, M. 1989. Presenile dementia associated with mosaic trisomy 21 in a patient with a down syndrome child. The Lancet 334(8665), pp. 743-743. (10.1016/S0140-6736(89)90805-2)
- Hardy, J., Goate, A., Owen, M. J., Mullan, M., Rossor, M. and Pearson, R. 1989. Modelling the occurrence and pathology of Alzheimer's disease. Neurobiology of Aging 10(5), pp. 429-431. (10.1016/0197-4580(89)90084-5)
- Owen, M. J., Lewis, S. W. and Murray, R. M. 1989. Family history and cerebral ventricular enlargement in schizophrenia. A case control study. British Journal of Psychiatry 154(5), pp. 629-634. (10.1192/bjp.154.5.629)
- Goate, A. et al. 1989. Predisposing locus for Alzheimer's disease on chromosome 21. The Lancet 333(8634), pp. 352-355. (10.1016/S0140-6736(89)91725-X)
- HARDY, J. A. et al. 1989. Molecular genetics of Alzheimer's disease. Biochemical Society Transactions 17(1), pp. 75-76. (10.1042/bst0170075)
1988
- Owen, M. J. and Murray, R. 1988. Blue genes. British Medical Journal (BMJ) 297(6653), pp. 871-872.
- Owen, M. J. and Lewis, S. W. 1988. Risk factors in schizophrenia. British Journal of Psychiatry 153(3), pp. 407-407. (10.1192/bjp.153.3.407a)
- Owen, M. J. and Whatley, S. 1988. Polymorphic DNA markers and mental disease. Psychological Medicine 18(3), pp. 529-533.
- Owen, M. J., Lewis, S. W. and Murray, R. M. 1988. Obstetric complications and schizophrenia: a computed tomographic study. Psychological Medicine 18(2), pp. 331-339. (10.1017/S003329170000787X)
1987
- Owen, M. J. and Nimgaonkar, V. 1987. The continuum of psychosis and the gene. British Journal of Psychiatry 150, pp. 566-567.
1986
- Owen, M. J. and Lweis, S. 1986. Lateral ventricular size in schizophrenia. The Lancet 2(8500), pp. 223-224.
1984
- Owen, M. J. and Butler, S. 1984. Does amnesia after transection of the fornix in monkeys reflect abnormal sensitivity to proactive interference?. Behavioural Brain Research 14(3), pp. 183-192.
- Gaffan, D., Saunders, R., Gaffan, E., Harrison, S., Shields, C. and Owen, M. J. 1984. Effects of fornix transection upon associative memory in monkeys: role of the hippocampus in learned action. Quarterly Journal of Experimental Psychology 36(3), pp. 173-221.
1981
- Owen, M. J. and Butler, S. 1981. Amnesia after transection of the fornix in monkeys: Long-term memory impaired, short-term memory intact. Behavioural Brain Research 3(1), pp. 115-123. (10.1016/0166-4328(81)90032-2)
1980
- Owen, M. J. and Butler, S. 1980. Effects of fornix lesions on recognition memory in the monkey. Journal of Anatomy 131(DEC), pp. 771-771.
- Owen, M. J. and Butler, S. 1980. The effects of fornix lesions on latent learning in the rat. Physiology & Behavior 24(5), pp. 817-822. (10.1016/0031-9384(80)90133-X)
Articles
- Legge, S. E. et al. 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 81, pp. 681-690. (10.1001/jamapsychiatry.2024.0200)
- Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)
- Owen, M. and O'Donovan, M. 2024. The genetics of cognition in schizophrenia.. Brain Medicine
- Hall, J. H. et al. 2024. Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs). Translational Psychiatry 14(1), article number: 259. (10.1038/s41398-024-02975-z)
- Stevenson-Hoare, J. et al. 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27(1), article number: e301097. (10.1136/bmjment-2024-301097)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14(1), article number: 256. (10.1038/s41398-024-02969-x)
- Cabezas De La Fuente, D. et al. 2024. Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a human stem cell model of neurodevelopmental disorder. Cell Reports 43(3), article number: 113946. (10.1016/j.celrep.2024.113946)
- Kopal, J. et al. 2024. Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 15(1), article number: 2639. (10.1038/s41467-024-46784-w)
- Kappel, D. et al. 2024. Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia. European Neuropsychopharmacology 80, pp. 47-54. (10.1016/j.euroneuro.2023.12.007)
- Tandon, R. et al. 2024. The schizophrenia syndrome, circa 2024: What we know and how that informs its nature. Schizophrenia Research 264, pp. 1-28. (10.1016/j.schres.2023.11.015)
- Doherty, J. L. et al. 2024. Atypical cortical networks in children at high-genetic risk of psychiatric and eurodevelopmental disorders. Neuropsychopharmacology 49, pp. 368-376. (10.1038/s41386-023-01628-x)
- Boen, R. et al. 2024. Beyond the global brain differences: Intra-individual variability differences in 1q21.1 distal and 15q11.2 BP1-BP2 deletion carriers. Biological Psychiatry 95(2), pp. 147-160. (10.1016/j.biopsych.2023.08.018)
- Peall, K. J., Owen, M. J. and Hall, J. 2024. Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes. Nature Reviews Neurology 20(1), pp. 7-21. (10.1038/s41582-023-00896-x)
- Ge, R. et al. 2024. Source‐based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome. Human Brain Mapping 45(1), article number: e26553. (10.1002/hbm.26553)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Chilvers, C. and Owen, M. J. 2023. Mental Health Research, shared goals. Journal of Mental Health 32, article number: 1017. (10.1080/09638237.2021.1898562)
- Caseras, X., Legge, S., Bracher-Smith, M., Anney, R., Owen, M., Escott-Price, V. and Kirov, G. 2023. Copy Number Variants increasing risk for schizophrenia: shared and distinct effects on brain morphometry and cognitive performance. Biological Psychiatry: Global Open Science 3(4), pp. 902-911. (10.1016/j.bpsgos.2022.10.006)
- Lock, S. K. et al. 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9, article number: 74. (10.1038/s41537-023-00404-6)
- Doherty, A., O'Donovan, M., Hamshere, M., Jones, I., Owen, M. and Walters, J. 2023. Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors. The American Journal of Psychiatry 180(10), pp. 723-738. (10.1176/appi.ajp.21121266)
- Owen, M., Legge, S., Rees, E., Walters, J. and O'Donovan, M. 2023. Genomic findings in schizophrenia and their implications. Molecular Psychiatry 28, pp. 3638-3647. (10.1038/s41380-023-02293-8)
- Kumar, K. et al. 2023. Subcortical brain alterations in carriers of genomic copy number variants. The American Journal of Psychiatry 180(9), pp. 685-698. (10.1176/appi.ajp.20220304)
- Le Guen, Y. et al. 2023. Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences 120(36), article number: e2302720120. (10.1073/pnas.2302720120)
- Ollà, I. et al. 2023. Pathogenic mis-splicing of CPEB4 in schizophrenia. Biological Psychiatry 94(4), pp. 341-351. (10.1016/j.biopsych.2023.03.010)
- Zhao, Y. et al. 2023. Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS. npj Genomic Medicine 8(1), article number: 17. (10.1038/s41525-023-00363-y)
- Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
- Kopal, J. et al. 2023. Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence. Nature Human Behaviour 7, pp. 1001-1007. (10.1038/s41562-023-01541-9)
- Chawner, S. J. et al. 2023. Neurodevelopmental dimensional assessment of young children at high genomic risk of neuropsychiatric conditions. JCPP Advances 3(2), article number: e12162. (10.1002/jcv2.12162)
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- Lin, J. et al. 2023. Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia. Molecular Psychiatry 28, pp. 2071-2080. (10.1038/s41380-023-02009-y)
- Chen, Z. et al. 2023. The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases. Neurobiology of Disease 180, article number: 106082. (10.1016/j.nbd.2023.106082)
- Moreau, C. A. et al. 2023. Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions. Brain 146(4), pp. 1686-1696. (10.1093/brain/awac315)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
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- Rammos, A., Kirov, G., Hubbard, L., Walters, J., Holmans, P., Owen, M. and Rees, E. 2023. Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia. Molecular Psychiatry 28, pp. 2081-2087. (10.1038/s41380-023-02013-2)
- Dimitriadis, S. I. et al. 2023. Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk. Cerebral Cortex 33(6), pp. 2997-3011. (10.1093/cercor/bhac256)
- Liu, D. et al. 2023. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics 55, pp. 369-376. (10.1038/s41588-023-01305-1)
- Owen, M. J. 2023. Genomic insights into schizophrenia. Royal Society Open Science 10(2), article number: 230125. (10.1098/rsos.230125)
- Moreau, C. A. et al. 2023. Genetic heterogeneity shapes brain connectivity in psychiatry. Biological Psychiatry 93(1), pp. 45-58. (10.1016/j.biopsych.2022.08.024)
- Kappel, D. B. et al. 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93, pp. 149-156. (10.1016/j.biopsych.2022.07.014)
- Wolstencroft, J. et al. 2023. Mental health impact of autism on families of children with intellectual and developmental disabilities of genetic origin. JCPP Advances, article number: e12128. (10.1002/jcv2.12128)
- Chawner, S. J. R. A., Evans, A., IMAGINE-ID consortium, ., Williams, N., Owen, M. J., Hall, J. and van den Bree, M. B. M. 2023. Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions. Translational Psychiatry 13, article number: 7. (10.1038/s41398-022-02296-z)
- Owen, M. J. 2022. The contribution of the Rüdin school to psychiatric genetics: the light and the darkness. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders 48(Supple), pp. S1-S3. (10.1093/schbul/sbac119)
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- Chawner, S. and Owen, M. 2022. Autism: a model of neurodevelopmental diversity informed by genomics. Frontiers in Psychiatry 13, article number: 981691. (10.3389/fpsyt.2022.981691)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE, a UK national cohort study. The Lancet Psychiatry 9(9), pp. 715-724. (10.1016/S2215-0366(22)00207-3)
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- Palmer, D. et al. 2022. Exome sequencing in bipolar disorder reveals AKAP11 as a risk gene shared with schizophrenia. Nature Genetics (10.1038/s41588-022-01034-x)
- Owen, M. and Legge, S. 2022. The nature of schizophrenia: as broad as it is long. Schizophrenia Research 242, pp. 109-112. (10.1016/j.schres.2021.10.012)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
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- Singh, T., Schizophrenia Exome Meta-Analysis (SCHEMA) Consortium, ., Kirov, G., Rees, E., Walters, J., Owen, M. and O'Donovan, M. 2022. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature 604, pp. 509-516. (10.1038/s41586-022-04556-w)
- Cunningham, A. C., Hall, J., Owen, M. and van den Bree, M. B. M. 2022. Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs. Psychological Medicine 52(3), pp. 574-586. (10.1017/S0033291720002330)
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- Vassos, E. et al. 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48(1), pp. 20-26. (10.1093/schbul/sbab052)
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- Plomin, R. et al. 1995. Allelic associations between 100 DNA markers and high versus low IQ. Intelligence 21(1), pp. 31. (10.1016/0160-2896(95)90037-3)
- Rees, M. I., Andrew, M., Jawad, S. and Owen, M. J. 1994. Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the alpha 1 subunit of the inhibitory glycine receptor. Human Molecular Genetics 3(12), pp. 2175-2179. (10.1093/hmg/3.12.2175)
- Craddock, N. J. and Owen, M. J. 1994. Is there an inverse relationship between Down's syndrome and bipolar affective disorder? literature review and genetic implications [Review]. Journal of Intellectual Disability Research 38(6), pp. 613-620. (10.1111/j.1365-2788.1994.tb00462.x)
- McGuffin, P., Owen, M. J., Asherson, P. and Farmer, A. E. 1994. Genetics, chance and dysmorphogenesis in schizophrenia. British Journal of Psychiatry 165, pp. 694-695. (10.1192/bjp.165.5.693b)
- Daniels, J., Williams, J., Mant, R., Asherson, P., McGuffin, P. and Owen, M. J. 1994. Repeat length variation in the dopamine D4 receptor gene shows no evidence of association with schizophrenia. American Journal of Medical Genetics 54(3), pp. 256-258. (10.1002/ajmg.1320540313)
- Craddock, N. J., McGuffin, P. and Owen, M. J. 1994. Darier's disease cosegregating with affective disorder [letter]. British Journal of Psychiatry 165(2), pp. 272-272. (10.1192/bjp.165.2.272a)
- Plomin, R., Owen, M. J. and McGuffin, P. 1994. The genetic basis of complex human behaviors. Science 264(5166), pp. 1733-1739. (10.1126/science.8209254)
- Craddock, N. J., Daniels, J., McGuffin, P. and Owen, M. J. 1994. Variation at the fragile X locus does not influence susceptibility to bipolar disorder. American Journal of Medical Genetics 54(2), pp. 141-143. (10.1002/ajmg.1320540209)
- Thapar, A., Gottesman, I. I., Owen, M. J., O'Donovan, M. C. and McGuffin, P. 1994. The genetics of mental retardation. The British Journal of Psychiatry 164(6), pp. 747. (10.1192/bjp.164.6.747)
- James, C. M., Daniels, J., Wiles, C. M. and Owen, M. J. 1994. Debrisoquine hydroxylase gene polymorphism in motor-neuron disease. Neurodegeneration 3(2), pp. 149-152.
- McGuffin, P., Asherson, P., Owen, M. J. and Farmer, A. 1994. The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia?. British Journal of Psychiatry 164(5), pp. 593-599. (10.1192/bjp.164.5.593)
- Asherson, P. et al. 1994. Imprinting and anticipation. Are they relevant to genetic studies of schizophrenia?. The British Journal of Psychiatry 164(5), pp. 619-624. (10.1192/bjp.164.5.619)
- Craddock, N. J. and Owen, M. J. 1994. Chromosomal aberrations and bipolar affective disorder [review]. British Journal of Psychiatry 164(4), pp. 507-512. (10.1192/bjp.164.4.507)
- Asherson, P., Williams, N. M., Roberts, E., McGuffin, M. and Owen, M. J. 1994. DRD2 Ser311/Cys311 polymorphism in schizophrenia. The Lancet 343(8904), pp. 1045-1045.
- Liddell, M. B., Williams, J., Bayer, A. J., Kaiser, F. and Owen, M. J. 1994. Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease. Journal of Medical Genetics 31(3), pp. 197-200. (10.1136/jmg.31.3.197)
- Craddock, N. J., Brockington, I., Mant, R., Parfitt, E., McGuffin, P. and Owen, M. J. 1994. Bipolar affective puerperal psychosis associated with consanguinity. British Journal of Psychiatry 164(3), pp. 359-364. (10.1192/bjp.164.3.359)
- Craddock, N. J., Owen, M. J., Burge, S., Kurian, B., Thomas, P. and McGuffin, P. 1994. Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis). British Journal of Psychiatry 164(3), pp. 355-358. (10.1192/bjp.164.3.355)
- Pulver, A. E. et al. 1994. Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. American Journal of Medical Genetics 54(1), pp. 44-50. (10.1002/ajmg.1320540109)
- Shaikh, S. et al. 1994. Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia. American Journal of Medical Genetics 54(1), pp. 8-11. (10.1002/ajmg.1320540104)
- Mant, R., Williams, J., Asherson, P., Parfitt, E., McGuffin, P. and Owen, M. J. 1994. Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. American Journal of Medical Genetics 54(1), pp. 21-26. (10.1002/ajmg.1320540106)
- Owen, M. J., Liddell, M. and McGuffin, P. 1994. Alzheimer's disease. British Medical Journal (BMJ) 308(6930), pp. 672-673. (10.1136/bmj.308.6930.672)
- Plomin, R. et al. 1994. DNA markers associated with high versus low IQ: The IQ quantitative trait loci (QTL) project. Behavior Genetics 24(2), pp. 107-118. (10.1007/BF01067815)
- Asherson, P. and Owen, M. J. 1994. Anticipation in mental illness. The American Journal of Human Genetics 54(2), pp. 386-387.
- Parfitt, E. et al. 1994. The gene for Darier's disease maps between D12S78 and D12S79. Human Molecular Genetics 3(1), pp. 35-38. (10.1093/hmg/3.1.35)
- Vallada, H., Gill, M., Nanko, S., Owen, M. J., Murray, R. and Collier, C. 1994. Is there a major gene for schizophrenia on chromosome-22. Schizophrenia Research 11(2), pp. 147-147.
- Korner, J. et al. 1994. Association and haplotype analysis at the tyrosine hydroxylase locus in a combined German-British sample of manic depressive patients and controls. Psychiatric Genetics 4(3), pp. 167-175. (10.1097/00041444-199400430-00007)
- Owen, M. J. 1994. The molecular genetics of Alzheimer's disease. Molecular and Cell Biology of Human Diseases Series 1994(4), pp. 92-109.
- Daniels, J. et al. 1994. IQ and variation in the number of fragile X CGG repeats: No association in a normal sample. Intelligence 19(1), pp. 45-50. (10.1016/0160-2896(94)90052-3)
- Craddock, N. J. et al. 1993. The gene for Darier's disease maps to chromosome 12q23-q24.1. Human Molecular Genetics 2(11), pp. 1941-1943. (10.1093/hmg/2.11.1941)
- McGuffin, P. and Owen, M. J. 1993. Molecular-genetics and schizophrenia - the current picture. Behavior Genetics 23(6), pp. 558-558.
- Saudino, K. J. et al. 1993. Applying a QTL association approach to temperament. Behavior Genetics 23(6), pp. 564-564.
- Asherson, P. et al. 1993. Failure to find linkage between schizophrenia and genetic markers on chromosome 21. American Journal of Medical Genetics 48(3), pp. 161-165. (10.1002/ajmg.1320480310)
- Mant, R., Williams, J., Asherson, P., Parfitt, E., McGuffin, P. and Owen, M. J. 1993. Susceptibility to schizophrenia and the dopamine d3 receptor gene. American Journal of Human Genetics 53(3), pp. 1654-1654.
- Owen, M. J. and McGuffin, P. 1993. Association and linkage: complementary strategies for complex disorders.. Journal of Medical Genetics 30(8), pp. 638-639. (10.1136/jmg.30.8.638)
- Shaikh, S. et al. 1993. The dopamine D3 receptor gene: no association with bipolar affective disorder. Journal of Medical Genetics 30(4), pp. 308-309. (10.1136/jmg.30.4.308)
- Gill, M. et al. 1993. A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychological Medicine 23(1), pp. 27-44. (10.1017/S0033291700038824)
- Jones, P. B., Owen, M. J., Lewis, S. W. and Murray, R. M. 1993. A case-control study of family history and cerebral cortical abnormalities in schizophrenia. Acta Psychiatrica Scandinavica 87(1), pp. 6-12. (10.1111/j.1600-0447.1993.tb03322.x)
- Craddock, N. J., Burge, S., Parfitt, L. and Owen, M. J. 1993. Linkage is excluded between Darier's disease and the Duffy blood group locus in five British families. Annales de Genetique 36(4), pp. 211-213.
- Owen, M. J. and Liddell, M. 1992. Role of amyloid beta-protein in Alzheimer's disease. The Lancet 340(8823), pp. 851-851.
- Owen, M. J. and McGuffin, P. 1992. The molecular genetics of schizophrenia.. British Medical Journal (BMJ) 305(6855), pp. 664-665. (10.1136/bmj.305.6855.664)
- Mant, R., Asherson, P., Gill, M., McGuffin, P. and Owen, M. J. 1992. Schizophrenia scepticism. Nature Genetics 2(1), pp. 12-12. (10.1038/ng0992-12)
- Owen, M. J. et al. 1992. No association between RFLPs at the porphobilinogen deaminase gene and schizophrenia. Human Genetics 90(1-2), pp. 131-132. (10.1007/BF00210756)
- Vallada, H., Collier, D., Dawson, E., Owen, M. J., Nanko, S., Murray, R. and Gill, M. 1992. Debrisoquine 4-hydroxylase (CYP2D) locus and possible susceptibility to schizophrenia. The Lancet 340(8812), pp. 181-182. (10.1016/0140-6736(92)93266-P)
- Asherson, P. et al. 1992. No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families. British Journal of Psychiatry 161(1), pp. 63-68. (10.1192/bjp.161.1.63)
- O'Donovan, M. C. and Owen, M. J. 1992. Advances and Retreats in the Molecular Genetics of Major Mental Illness. Annals of Medicine 24(3), pp. 171-177. (10.3109/07853899209147816)
- Craddock, N. J. and Owen, M. J. 1992. Christmas disease and major affective disorder [letter]. British Journal of Psychiatry 160, pp. 715-715. (10.1192/bjp.160.5.715a)
- Nanko, S., Gill, M., Owen, M. J., Takazawa, N., Moridaira, J. and Kazamatsuri, H. 1992. Linkage Study of Schizophrenia with Markers on Chromosome 11 in Two Japanese Pedigrees. Psychiatry and Clinical Neurosciences 46(1), pp. 155-159. (10.1111/j.1440-1819.1992.tb00828.x)
- Shaikh, S., Owen, M. J. and Gill, M. 1992. DRD2 (TGn) repeat polymorphism in a large family data set. Schizophrenia Research 6(2), pp. 91-91. (10.1016/0920-9964(92)90088-M)
- Dawson, E. et al. 1992. Genetic linkage analysis of schizophrenia using microsatellite repeat polymorphisms on chromosome 12. Schizophrenia Research 6(2), pp. 90-90. (10.1016/0920-9964(92)90086-K)
- Collier, D., Gill, M., Nanko, S., Owen, M. J. and Vallada, H. 1992. Linkage analysis of schizophrenia on chromosome 22. Schizophrenia Research 6(2), pp. 89-90. (10.1016/0920-9964(92)90085-J)
- Owen, M. J. and GILL, M. 1992. Looking for genes in schizophrenia. Clinical Neuropharmacology 15(Suppl1), pp. 222A-223A. (10.1097/00002826-199201001-00116)
- Upadhyaya, M., Lunt, P. W., Sarfarazi, M., Broadhead, W., Daniels, J., Owen, M. J. and Harper, P. S. 1991. A closely linked DNA marker for facioscapulohumeral disease on chromosome 4q.. Journal of Medical Genetics 28(10), pp. 665-671. (10.1136/jmg.28.10.665)
- Owen, M. J. et al. 1991. Linkage studies of schizophrenia with markers of chromosome-11q. American Journal of Human Genetics 49(4), pp. 354-354.
- Mant, R., Parfitt, E., Hardy, J. and Owen, M. J. 1991. Mononucleotide repeat polymorphism in the APP gene. Nucleic Acids Research 19(16), pp. 4572-4572. (10.1093/nar/19.16.4572-a)
- Owen, M. J., Goate, A. and Hardy, J. 1991. A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80). Nucleic Acids Research 19(16), pp. 4574-4571. (10.1093/nar/19.16.4574)
- Foerster, A., Lewis, S. W., Owen, M. J. and Murray, R. M. 1991. Low birth weight and a family history of schizophrenia predict poor premorbid functioning in psychosis. Schizophrenia Research 5(1), pp. 13-20. (10.1016/0920-9964(91)90049-W)
- Goate, A. et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349(6311), pp. 704-706. (10.1038/349704a0)
- Foerster, A., Lewis, S., Owen, M. J. and Murray, R. 1991. Pre-morbid adjustment and personality in psychosis. Effects of sex and diagnosis. British Journal of Psychiatry 158(2), pp. 171-176. (10.1192/bjp.158.2.171)
- Owen, M. J. and McGuffin, P. 1991. DNA-and classical genetic markers in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 240(3), pp. 197-203. (10.1007/BF02190764)
- McGuffin, P. and Owen, M. J. 1991. The molecular genetics of schizophrenia: An overview and forward view. European Archives of Psychiatry and Clinical Neuroscience 240(3), pp. 169-173. (10.1007/BF02190759)
- Mant, R. et al. 1991. Exclusion of close linkage between GABA a receptor subunit 1a gene and schizophrenia using a microsatellite repeat marker. Cytogenetics and Cell Genetics 58(3-4), pp. 1900-1991.
- Upadhyaya, M., Lunt, P., Sarfarazi, M., Broadhead, W., Daniels, J., Owen, M. J. and Harper, P. 1990. DNA marker applicable to presymptomatic and prenatal diagnosis of facioscapulohumeral disease. The Lancet 336(8726), pp. 1320-1321. (10.1016/0140-6736(90)93005-A)
- St George-Hyslop, P. H. et al. 1990. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 347(6289), pp. 194-197. (10.1038/347194a0)
- Owen, M. J., McGuffin, P. and Andrews, R. 1990. Obstetric complications and schizophrenia. The Lancet 336(8707), pp. 122-122. (10.1016/0140-6736(90)91643-O)
- Owen, M. J., Craufurd, D. and St Clair, D. 1990. Localisation of a susceptibility locus for schizophrenia on chromosome 5. British Journal of Psychiatry 157(1), pp. 123-127. (10.1192/bjp.157.1.123)
- Owen, M. J., James, L., Hardy, J., Williamson, R. and Goate, A. 1990. Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.. American Journal of Human Genetics 46(2), pp. 316-322.
- Owen, M. J. and Mullan, M. J. 1990. Molecular genetic studies of manic-depression and schizophrenia. Trends in Neurosciences 13(1), pp. 29-31. (10.1016/0166-2236(90)90059-J)
- Goate, A. et al. 1990. Genetics of Alzheimer's disease. Advances in Neurology -New York- Raven Press- 51, pp. 197-198.
- Hardy, J., Goate, A., Owen, M. J. and Rossor, M. 1989. Presenile dementia associated with mosaic trisomy 21 in a patient with a down syndrome child. The Lancet 334(8665), pp. 743-743. (10.1016/S0140-6736(89)90805-2)
- Hardy, J., Goate, A., Owen, M. J., Mullan, M., Rossor, M. and Pearson, R. 1989. Modelling the occurrence and pathology of Alzheimer's disease. Neurobiology of Aging 10(5), pp. 429-431. (10.1016/0197-4580(89)90084-5)
- Owen, M. J., Lewis, S. W. and Murray, R. M. 1989. Family history and cerebral ventricular enlargement in schizophrenia. A case control study. British Journal of Psychiatry 154(5), pp. 629-634. (10.1192/bjp.154.5.629)
- Goate, A. et al. 1989. Predisposing locus for Alzheimer's disease on chromosome 21. The Lancet 333(8634), pp. 352-355. (10.1016/S0140-6736(89)91725-X)
- HARDY, J. A. et al. 1989. Molecular genetics of Alzheimer's disease. Biochemical Society Transactions 17(1), pp. 75-76. (10.1042/bst0170075)
- Owen, M. J. and Murray, R. 1988. Blue genes. British Medical Journal (BMJ) 297(6653), pp. 871-872.
- Owen, M. J. and Lewis, S. W. 1988. Risk factors in schizophrenia. British Journal of Psychiatry 153(3), pp. 407-407. (10.1192/bjp.153.3.407a)
- Owen, M. J. and Whatley, S. 1988. Polymorphic DNA markers and mental disease. Psychological Medicine 18(3), pp. 529-533.
- Owen, M. J., Lewis, S. W. and Murray, R. M. 1988. Obstetric complications and schizophrenia: a computed tomographic study. Psychological Medicine 18(2), pp. 331-339. (10.1017/S003329170000787X)
- Owen, M. J. and Nimgaonkar, V. 1987. The continuum of psychosis and the gene. British Journal of Psychiatry 150, pp. 566-567.
- Owen, M. J. and Lweis, S. 1986. Lateral ventricular size in schizophrenia. The Lancet 2(8500), pp. 223-224.
- Owen, M. J. and Butler, S. 1984. Does amnesia after transection of the fornix in monkeys reflect abnormal sensitivity to proactive interference?. Behavioural Brain Research 14(3), pp. 183-192.
- Gaffan, D., Saunders, R., Gaffan, E., Harrison, S., Shields, C. and Owen, M. J. 1984. Effects of fornix transection upon associative memory in monkeys: role of the hippocampus in learned action. Quarterly Journal of Experimental Psychology 36(3), pp. 173-221.
- Owen, M. J. and Butler, S. 1981. Amnesia after transection of the fornix in monkeys: Long-term memory impaired, short-term memory intact. Behavioural Brain Research 3(1), pp. 115-123. (10.1016/0166-4328(81)90032-2)
- Owen, M. J. and Butler, S. 1980. Effects of fornix lesions on recognition memory in the monkey. Journal of Anatomy 131(DEC), pp. 771-771.
- Owen, M. J. and Butler, S. 1980. The effects of fornix lesions on latent learning in the rat. Physiology & Behavior 24(5), pp. 817-822. (10.1016/0031-9384(80)90133-X)
Book sections
- Kendall, K., Kirov, G. and Owen, M. 2017. Schizophrenia Genetics. In: Benjamin, S., Virginia, S. and Pedro, R. eds. Kaplan and Sadock?s Comprehensive Textbook of Psychiatry. Wolters Kluwer
- Smith, D. J., Owen, M. J. and Craddock, N. J. 2009. Bipolar disorder and unipolar depression: what is the genetic relationship?. In: Pariante, C. M. et al. eds. Understanding Depression: a Translational Approach. Oxford: Oxford University Press, pp. 67-76.
- Kirov, G. and Owen, M. J. 2009. Genetics of schizophrenia. In: Sadock, B. J., Sadock, V. A. and Ruiz, P. eds. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry. 9th ed.., Vol. 1. Philadelphia: Lippincott Williams and Wilkins, pp. 1462-1474.
- O'Donovan, M. C. and Owen, M. J. 2003. Genetic findings in psychotic disorders. In: Soares, J. C. and Gershon, S. eds. Handbook of Medical Psychiatry. New York: Marcel Dekker, pp. 417-432.
- Owen, M. J. and O'Donovan, M. C. 2003. Schizophrenia and genetics. In: Plomin, R. et al. eds. Behavioral Genetics in the Postgenomic Era. Washington, DC: APA Books, pp. 463-480., (10.1037/10480-023)
- Thapar, A. and Scourfield, J. 2002. Childhood disorders. In: McGuffin, P., Owen, M. J. and Gottesman, I. I. eds. Psychiatric Genetics and Genomics. Oxford Medical Publications Oxford: Oxford University Press, pp. 147-181.
- Scourfield, J. and Owen, M. J. 2002. Genetic counselling. In: McGuffin, P., Owen, M. J. and Gottesman, I. I. eds. Psychiatric Genetics and Genomics. Oxford Medical Publications Oxford: Oxford University Press, pp. 415-424.
- Zammit, S., O'Donovan, M. C. and Owen, M. J. 2002. Neurogenetics of schizophrenia. In: D'haenen, H., den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley, pp. 663-671., (10.1002/0470854871.chxvii9)
- Tsuang, M. T. and Owen, M. J. 2002. Molecular and population genetics of schizophrenia. In: Davis, K. L. et al. eds. Neuropsychopharmacology - 5th Generation of Progress. Philadelphia, PA: Lippincott, Williams and Wilkins, pp. 671-687.
Books
- McGuffin, P., Owen, M. J., O'Donovan, M. C., Thapar, A. and Gottesman, I. I. 1994. Seminars in psychiatric genetics. Gaskell, Royal College of Psychiatrists.
Conferences
- Eaton, C. B. et al. 2019. Prevalence and aetiology of epileptic seizures in young people with 22Q11.2 Deletion syndrome and relationships with other neurodevelopmental disorders. Presented at: SSBP 22nd Educational Day and Research Symposium 2019, Birmingham, England, 4-6 September 2019, Vol. 63. Vol. 9. Wiley pp. 1080., (10.1111/jir.12676)
- Brieva, J. et al. 2018. Alternative diffusion anisotropy measures for the investigation of white matter alterations in 22q11.2 deletion syndrome. Presented at: 14th International Symposium on Medical Information Processing and Analysis,, Mazatlán, Mexico, 24-26 October 2018 Presented at Romero, E., Lepore, N. and Brieva, J. eds.14th International Symposium on Medical Information Processing and Analysis, Vol. 10975. Proceedings of SPIE Bellingham, Washington: SPIE pp. 51., (10.1117/12.2513788)
- 2001. Evidence of association between DRD4 and ADHD with conduct disturbance. Presented at: Behavior Genetics Association Meeting, Cambridge, 11 July 2001 Presented at Thapar, A. et al. eds.Behavior Genetics, Vol. 31. Behavior Genetics Association Meeting Abstracts Vol. 5. Springer Verlag pp. 470-471.
Websites
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE - The UK National Cohort Study. [Online]. papers.SSRN.com: Elsevier. (10.2139/ssrn.4028542) Available at: http://dx.doi.org/10.2139/ssrn.4028542
- Chawner, S., Owen, M. J., Holmans, P., Raymond, L., Skuse, D., Hall, J. and van den Bree, M. 2019. Genotype-phenotype relationships in children with copy number variants associated with high neuropsychiatric risk: Findings from the Intellectual Disability & Mental Health: Assessing the Genomic Impact on Neurodevelopment (IMAGINE-ID) study.. [Online]. BioRxiv. (10.1101/535708) Available at: https://doi.org/10.1101/535708
- Allardyce, J. et al. 2017. Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia. [Online]. bioRxiv. Available at: http://dx.doi.org/10.1101/160119
- Pardinas, A. et al. 2016. Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection. [Online]. bioRxiv. (10.1101/068593) Available at: http://dx.doi.org/10.1101/068593
Research
My work uses a combination of molecular genetic approaches including genome-wide association, copy number variant analysis and next generation sequencing to identify the specific genetic variants that confer risk to psychiatric and neurodegenerative disorders. For the past 10 years I have also been studying psychopathological and cognitive outcomes in high-risk children.
I am increasingly interested in the impact of genetic discoveries on the understanding of disease mechanisms and classification. My genetics work has implicated specific sets of postsynaptic proteins in psychiatric disorders particularly schizophrenia but also autism and intellectual disability. I am PI of the DEFINE programme (funded by a Wellcome Trust Strategic Award) which aims to understand how mutations in the genes encoding postsynaptic proteins impact brain function and behaviour using a combination of human brain imaging, animal models and stem cell research.
Current grants
- October 2018 – October 2022, £ 2,960,749. To establish a scalable set of assay platforms against which the phenotype consequences of manipulating the identified exclusive targets can be screened and effects the drug compounds assessed to develop therapeutics for schizophrenia. Wilkinson L, Humby T, Bray N, Gray W, Hall J, Jones I, Li M, Owen M, Van Den Bree M, Walters J, Harwood A, Thomas K. Takeda Pharmaceutical Company Ltd.
- October 2018 – October 2022, £1,021,691. Identify new potential cellular targets (pathways, molecules, genes) for therapeutic intervention in schizophrenia. Wilkinson L, Hall J, O'Donovan M, Owen M, Pocklington A, Walters J, Williams N, Harwood A, Thomas K. Takeda Pharmaceutical Company Ltd.
- January 2018 – December 2021, £310,234. Stratification of bipolar disorder: harnessing clinical heterogeneity and genetics shared with other disorders. (Career Re-Entry Fellowship, J Allardyce). Allardyce J, Escott-Price V, Jones IR, Owen MJ, O'Donovan MC. Wellcome Trust.
- December 2016 – November 2021, £3,008,874. Molecular genetic studies of schizophrenia. Owen M, O'Donovan M, Holmans P, Walters J, Pocklington A, Escott-Price V. Medical Research Council.
- January 2016 – December 2020, €224,500. Comorbidity and synapse biology in clinically overlapping psychiatric disorders (COSYN). Owen MJ, O’Donovan MC. European Commission (Horizon 2020).
- March 2018 – March 2020, £971,676. Integrating genetic, clinical and phenotypic data to advance stratification, prediction and treatment in mental health. Hall J, Walters J, Owen M, Thapar A, Rice F, O'Donovan M, Jones I, Collishaw S, Holmans P, Singh K, Van Goozen S, Langley K, Murphy S, Moore G, Atack J, Harwood A. Medical Research Council.
- February 2016 – January 2020, £250,000. Attention Deficit Hyperactivity Disorder (ADHD) inattention symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome and the contribution of genetic risk. Niarchou M, Owen MJ. Wellcome Trust.
- January 2016 – December 2019, £452,826. HiSeq 4000 Sequencing System. Owen MJ, O'Donovan MC, Williams NM, Mantripragada KK. Welsh Government.
- November 2014 – November 2019, £2,359,893, MRC Centre for Neuropsychiatric Genetics and Genomics (renewal) Owen MJ, O’Donovan MC. Medical Research Council.
- February 2015 – July 2019, £1,063,062. Intellectual disability and mental health: Assessing genomic impact on neurodevelopment (IMAGINE). Hall J, Kerr M, Owen M, van den Bree M. Medical Research Council.
Teaching
As Head of the Division of Psycological Medicine and Neurosciences, I am responsible for UG teaching in psychiatry and neurology.
Biography
Honours and awards
I was elected to Fellowship of the Royal College of Psychiatrists in 1997, Fellowship of the Academy of Medical Sciences in 1999 and Fellowship of the Learned Society of Wales in 2012.
In 2011, I was awarded the Stromgren Medal for psychiatric research, in 2012 the Lieber Prize for schizophrenia research and in 2013 the William K Warren Distinguished Investigator Award for schizophrenia research, the Lifetime Achievement Award of the International Society of Psychiatric Genetics in 2015, and the British Neuroscience Association Award for Outstanding Contribution to Neuroscience in 2017. I was awarded MD (honoris causa) by the University of Birmingham in 2018.
In 2014 I was knighted for services to Neuroscience and Mental Health. In 2016, the MRC Centre fro Neuropsychiatric Genetics and Genomics was awarded the Queen’s Anniversary Prize.
Professional memberships
- Academy of Medical Sciences
- Learned Society of Wales
- Royal College of Psychiatrists
- British Neuroscience Association
- International Society of Psychiatric Genetics