![Dimitris Parthimos](https://profiles-cardiff.imgix.net/attachments/7083?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
I am a bio-mathematician based at the Division of Cancer and Genetics. Over the past two decades I have been working closely with lab biologists and clinical academics, developing novel tools and approaches to understand cellular mechanisms of physiology and disease. I have been heading the mathematical/computational component in several collaborative projects, while leading a number of multi-disciplinary initiatives.
Publication
2021
- de Almeida, A., Parthimos, D., Dew, H., Smart, O., Wiltshire, M. and Errington, R. J. 2021. Aquaglyceroporin-3’s expression and cellular localization is differentially modulated by hypoxia in prostate cancer cell lines. Cells 10(4), article number: 838. (10.3390/cells10040838)
- Seidel, M. et al. 2021. Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. Cardiovascular Research 117(3), pp. 780-791., article number: cvaa043. (10.1093/cvr/cvaa043)
2018
- Coccarelli, A., Hasan, H. M., Carson, J., Parthimos, D. and Nithiarasu, P. 2018. Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study. International Journal for Numerical Methods in Biomedical Engineering e3120 (10.1002/cnm.3120)
- Coccarelli, A., Edwards, D. H., Aggarwal, A., Nithiarasu, P. and Parthimos, D. 2018. A multiscale active structural model of the arterial wall accounting for smooth muscle dynamics. Journal of the Royal Society Interface 15(139), article number: 20170732. (10.1098/rsif.2017.0732)
2017
- Coccarelli, A., Boileau, E., Parthimos, D. and Nithiarasu, P. 2017. Modelling accidental hypothermia effects on a human body under different pathophysiological conditions. Medical and Biological Engineering and Computing 55, pp. 2155-2167. (10.1007/s11517-017-1657-3)
2016
- Coccarelli, A., Boileau, E., Parthimos, D. and Nithiarasu, P. 2016. An advanced computational bioheat transfer model for a human body with an embedded systemic circulation. Biomechanics and Modeling in Mechanobiology 15(5), pp. 1173-1190. (10.1007/s10237-015-0751-4)
2015
- Nomikos, M. et al. 2015. Essential role of the EF-hand domain in targeting sperm phospholipase Cζ to membrane phosphatidylinositol 4,5-bisphosphate (PIP2). Journal of Biological Chemistry 290(49), pp. 29519-29530. (10.1074/jbc.M115.658443)
- Boileau, E., George, C. H., Parthimos, D., Mitchell, A. N., Aziz, S. and Nithiarasu, P. 2015. Synergy between intercellular communication and intracellular Ca2+ handling in arrhythmogenesis. Annals of Biomedical Engineering 43, pp. 1614-1625. (10.1007/s10439-014-1243-x)
2014
- Nomikos, M. et al. 2014. Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca2+ oscillations required for mammalian oocyte activation. Molecular Human Reproduction 20(6), pp. 489-498. (10.1093/molehr/gau011)
2013
- Theodoridou, M. et al. 2013. Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization. Molecular Human Reproduction 19(12), pp. 852-864. (10.1093/molehr/gat070)
2012
- George, C., Parthimos, D. and Silvester, N. C. 2012. A network-oriented perspective on cardiac calcium signaling. American Journal of Physiology - Cell Physiology 303(9), pp. C897-C910. (10.1152/ajpcell.00388.2011)
2007
- Parthimos, D., Haddock, R. E., Hill, C. E. and Griffith, T. M. 2007. Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment. Biophysical Journal 93(5), pp. 1534-1556. (10.1529/biophysj.107.106278)
2004
- Parthimos, D., Osterloh, K., Pries, A. R. and Griffith, T. M. 2004. Deterministic nonlinear characteristics of in vivo blood flow velocity and arteriolar diameter fluctuations. Physics in medicine and biology 49(9), pp. 1789-1802. (10.1088/0031-9155/49/9/014)
2003
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 2003. Shil'nikov homoclinic chaos is intimately related to type-III intermittency in isolated rabbit arteries: role of nitric oxide. Phys Rev E Stat Nonlin Soft Matter Phys 67(5), article number: 51922. (10.1103/PhysRevE.67.051922)
2001
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 2001. Universal scaling properties of type-I intermittent chaos in isolated resistance arteries are unaffected by endogenous nitric oxide synthesis. Phys Rev E Stat Nonlin Soft Matter Phys 64(6), article number: 61906. (10.1103/PhysRevE.64.061906)
1999
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 1999. Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+oscillators. American Journal of Physiology - Heart and Circulatory Physiology 277(3 pt 2), pp. H1119-H1144.
1997
- Griffith, T. M., Parthimos, D., Crombie, J. and Edwards, D. H. 1997. Critical scaling and type-III intermittent chaos in isolated rabbit resistance arteries [Rapid communication]. Physical Review E 56(6), pp. R6287-R6290. (10.1103/PhysRevE.56.R6287)
1996
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 1996. Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow. Cardiovascular Research 31(3), pp. 388-399. (10.1016/S0008-6363(95)00123-9)
Articles
- de Almeida, A., Parthimos, D., Dew, H., Smart, O., Wiltshire, M. and Errington, R. J. 2021. Aquaglyceroporin-3’s expression and cellular localization is differentially modulated by hypoxia in prostate cancer cell lines. Cells 10(4), article number: 838. (10.3390/cells10040838)
- Seidel, M. et al. 2021. Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. Cardiovascular Research 117(3), pp. 780-791., article number: cvaa043. (10.1093/cvr/cvaa043)
- Coccarelli, A., Hasan, H. M., Carson, J., Parthimos, D. and Nithiarasu, P. 2018. Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study. International Journal for Numerical Methods in Biomedical Engineering e3120 (10.1002/cnm.3120)
- Coccarelli, A., Edwards, D. H., Aggarwal, A., Nithiarasu, P. and Parthimos, D. 2018. A multiscale active structural model of the arterial wall accounting for smooth muscle dynamics. Journal of the Royal Society Interface 15(139), article number: 20170732. (10.1098/rsif.2017.0732)
- Coccarelli, A., Boileau, E., Parthimos, D. and Nithiarasu, P. 2017. Modelling accidental hypothermia effects on a human body under different pathophysiological conditions. Medical and Biological Engineering and Computing 55, pp. 2155-2167. (10.1007/s11517-017-1657-3)
- Coccarelli, A., Boileau, E., Parthimos, D. and Nithiarasu, P. 2016. An advanced computational bioheat transfer model for a human body with an embedded systemic circulation. Biomechanics and Modeling in Mechanobiology 15(5), pp. 1173-1190. (10.1007/s10237-015-0751-4)
- Nomikos, M. et al. 2015. Essential role of the EF-hand domain in targeting sperm phospholipase Cζ to membrane phosphatidylinositol 4,5-bisphosphate (PIP2). Journal of Biological Chemistry 290(49), pp. 29519-29530. (10.1074/jbc.M115.658443)
- Boileau, E., George, C. H., Parthimos, D., Mitchell, A. N., Aziz, S. and Nithiarasu, P. 2015. Synergy between intercellular communication and intracellular Ca2+ handling in arrhythmogenesis. Annals of Biomedical Engineering 43, pp. 1614-1625. (10.1007/s10439-014-1243-x)
- Nomikos, M. et al. 2014. Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca2+ oscillations required for mammalian oocyte activation. Molecular Human Reproduction 20(6), pp. 489-498. (10.1093/molehr/gau011)
- Theodoridou, M. et al. 2013. Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization. Molecular Human Reproduction 19(12), pp. 852-864. (10.1093/molehr/gat070)
- George, C., Parthimos, D. and Silvester, N. C. 2012. A network-oriented perspective on cardiac calcium signaling. American Journal of Physiology - Cell Physiology 303(9), pp. C897-C910. (10.1152/ajpcell.00388.2011)
- Parthimos, D., Haddock, R. E., Hill, C. E. and Griffith, T. M. 2007. Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment. Biophysical Journal 93(5), pp. 1534-1556. (10.1529/biophysj.107.106278)
- Parthimos, D., Osterloh, K., Pries, A. R. and Griffith, T. M. 2004. Deterministic nonlinear characteristics of in vivo blood flow velocity and arteriolar diameter fluctuations. Physics in medicine and biology 49(9), pp. 1789-1802. (10.1088/0031-9155/49/9/014)
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 2003. Shil'nikov homoclinic chaos is intimately related to type-III intermittency in isolated rabbit arteries: role of nitric oxide. Phys Rev E Stat Nonlin Soft Matter Phys 67(5), article number: 51922. (10.1103/PhysRevE.67.051922)
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 2001. Universal scaling properties of type-I intermittent chaos in isolated resistance arteries are unaffected by endogenous nitric oxide synthesis. Phys Rev E Stat Nonlin Soft Matter Phys 64(6), article number: 61906. (10.1103/PhysRevE.64.061906)
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 1999. Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+oscillators. American Journal of Physiology - Heart and Circulatory Physiology 277(3 pt 2), pp. H1119-H1144.
- Griffith, T. M., Parthimos, D., Crombie, J. and Edwards, D. H. 1997. Critical scaling and type-III intermittent chaos in isolated rabbit resistance arteries [Rapid communication]. Physical Review E 56(6), pp. R6287-R6290. (10.1103/PhysRevE.56.R6287)
- Parthimos, D., Edwards, D. H. and Griffith, T. M. 1996. Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow. Cardiovascular Research 31(3), pp. 388-399. (10.1016/S0008-6363(95)00123-9)
Research
My recent work at the Division of Cancer and Genetics (DCG) employs bio-mathematical techniques we previously developed, towards the study of complex tissue microenvironment signalling in tumours. This involves studying the cellular origins of cancer, and disease manifestation at the organ and system levels. Research, closely aligned with the Tissue Microenvironment Group (TMEG), includes models of tumour vascularization as a conduit for tissue oxygenation and metabolic homeostasis. To facilitate this and related work on cancer cell division dynamics, we established international collaborations between US and UK partners.
I am also closely involved in prostate cancer research employing novel molecular biomarkers (associated with extracellular vesicle-mediated signalling) for the accurate characterisation of disease progression. Work involves machine learning classification technology that significantly improves prostate cancer diagnosis.
Work within DCG is underpinned by state-of-the-art bioimaging. I have been coordinating the image analysis sector of TMEG research, while leading initiatives towards standardization and provenance of experimental/analytical protocols. Work has led to an ongoing close cooperation with the US National Institute of Standards and Technology (NIST). We have installed pioneering NIST image analysis technology in Cardiffa and establish a consortium involving NIST, the University of Illinois and CompSci at Cardiff to develop artificial intelligence-assisted frameworks for bio-data analytics, towards future diagnostic modalities.
Within DCG, we work on mTOR pathways in cancer progression, and modelling telomere length changes in cancer cells.
