Mr Darius Pease
(he/him)
MSci (Biochemistry)
PhD Researcher in Lung Epigenetics
School of Biosciences
Overview
As a PhD research candidate in the Lung Epigenetics group at Cardiff University, I am investigating the role of aberrant epigenetic modifications, namely DNA methylation changes, that have been observed in the lungs of patients with Chronic Lung disorders (e.g. COPD, IPF). To achieve this, I am establishing molecular toolset that allow the targeted introduction of epigenetic modifications into primary and immortalised human lung cell models, and exploring how these changes affect key disease pathways, such as capacity for repair and cell signalling.
Publication
2023
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
2022
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
Articles
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
Websites
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
Biography
Honours and awards
K.S. Dodgson Memorial Prize, 2018
Speaking engagements
"Establishing a toolset for epigenetic editing in human lung cells", Clinical Epigenetics International Conference (CLEPIC), Warsaw, Poland (2024)
Contact Details
Research themes
Specialisms
- Synthetic biology
- Epigenetics
- Molecular biology
- Biochemistry