![Jack Reddaway](https://profiles-cardiff.imgix.net/attachments/1185?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
I am currently a senior post-doctoral researcher in lab of Professor Paul Morgan and Dr Wioleta Zelek, research novel therapeutic avenues for the treatment of Alzheimer’s Disease.
I have expertise in high-throughput cellular imaging, cellular reconstruction and rodent cognitive assessment which I have put to good use throughout my PhD and subsequent post-doctoral research.
My research interests focus upon the role microglia play in modifying neuronal function and cognition. Understanding the complex relationship between microglia and neurons is of particular importance given that dysfunctional microglia-neuronal interactions are implicated in the aetiology of many neurodevelopmental and neurodegenerative disorders.
Publication
2023
- Reddaway, J., Richardson, P. E., Bevan, R. J., Stoneman, J. and Palombo, M. 2023. Microglial morphometric analysis: so many options, so little consistency. Frontiers in Neuroinformatics 17, article number: 1211188. (10.3389/fninf.2023.1211188)
2022
- Poppelaars, F., da Costa, M. G., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. Early-Career Complementologists (ECCO): past achievements and future directions. Molecular Immunology 151, pp. 158-165. (10.1016/j.molimm.2022.08.012)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
- Poppelaars, F., Gaya da Costa, M., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. ECCO - A new initiative to support early-career researchers in the complement field. Molecular Immunology 141, pp. 104-107. (10.1016/j.molimm.2021.11.018)
- Reddaway, J. 2022. The role of the complement system in associative learning and risk for schizophrenia. PhD Thesis, Cardiff University.
2020
- Reddaway, J. and Brydges, N. M. 2020. Enduring neuroimmunological consequences of developmental experiences: from vulnerability to resilience. Molecular and Cellular Neuroscience 109, article number: 103567. (10.1016/j.mcn.2020.103567)
- Brydges, N. and Reddaway, J. 2020. Neuroimmunological effects of early life experiences. Brain and Neuroscience Advances 4 (10.1177/2398212820953706)
2018
- Reddaway, J., Doherty, J. L., Lancaster, T., Linden, D., Walters, J. T. and Hall, J. 2018. Genomic and imaging biomarkers in schizophrenia. In: Current Topics in Behavioral Neurosciences. Berlin and Heidelberg: Springer, pp. 325-352., (10.1007/7854_2018_52)
Articles
- Reddaway, J., Richardson, P. E., Bevan, R. J., Stoneman, J. and Palombo, M. 2023. Microglial morphometric analysis: so many options, so little consistency. Frontiers in Neuroinformatics 17, article number: 1211188. (10.3389/fninf.2023.1211188)
- Poppelaars, F., da Costa, M. G., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. Early-Career Complementologists (ECCO): past achievements and future directions. Molecular Immunology 151, pp. 158-165. (10.1016/j.molimm.2022.08.012)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
- Poppelaars, F., Gaya da Costa, M., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. ECCO - A new initiative to support early-career researchers in the complement field. Molecular Immunology 141, pp. 104-107. (10.1016/j.molimm.2021.11.018)
- Reddaway, J. and Brydges, N. M. 2020. Enduring neuroimmunological consequences of developmental experiences: from vulnerability to resilience. Molecular and Cellular Neuroscience 109, article number: 103567. (10.1016/j.mcn.2020.103567)
- Brydges, N. and Reddaway, J. 2020. Neuroimmunological effects of early life experiences. Brain and Neuroscience Advances 4 (10.1177/2398212820953706)
Book sections
- Reddaway, J., Doherty, J. L., Lancaster, T., Linden, D., Walters, J. T. and Hall, J. 2018. Genomic and imaging biomarkers in schizophrenia. In: Current Topics in Behavioral Neurosciences. Berlin and Heidelberg: Springer, pp. 325-352., (10.1007/7854_2018_52)
Thesis
- Reddaway, J. 2022. The role of the complement system in associative learning and risk for schizophrenia. PhD Thesis, Cardiff University.
Biography
EDUCATION
Hodge Centre for Neuropsychiatric Immunology, Cardiff University, Cardiff, UK
PhD (Medicine) 2017 - 2021
Project title: The role of the complement system in associative leaning and risk for schizophrenia
Univeristy of Bath, Bath, UK
BSc Honors in Biochemistry 2012 – 2016
RESEARCH EXPERIENCE
School of Medicine, Cardiff University, Cardiff, UK
Senior post-doctoral research associate 2024 – present
Project investigating developing and testing novel therapeutics for the treatment of Alzheimer's disease
School of Biosciences, Cardiff University, Cardiff, UK
Post-doctoral research associate 2021 – 2024
Project investigating the impact of Prader-Willi syndrome associated gene non-coding RNA Snord116 deletion upon cortical and hippocampal neuronal development.
Embark Biotech, Copenhagen Denmark
Visiting researcher 2022 - 2022
Hodge Centre for Neuropsychiatric Immunology, Cardiff University, Cardiff, UK
Phd 2017 – 2021
Project investigating immune activation following the retrieval or extinction of contextual fear memories. Developed a novel platform to assess the morphology of >10,000 microglia and predict activation status of said microglia using machine learning.
Translational Neurotrauma, Child Health, University of Arizona College of Medicine, Phoenix, AZ
University of Bath Placement Student 2014 - 2015
Honours and awards
2023 Travel Award, Foundation for Prader-Willi Research
2023 Travel Award, Guarantors of Brain
2022 Grant Project, Embark Biotech
2022 Travel Award, Foundation for Prader-Willi Research
2022 Project Grant, Foundation for Prader-Willi Research
2021 Research Wales Innovation Grant, Welsh Government
2019 Travel Award, Hycult Biotech
2018 Travel Award, Cold Spring Harbor Laboratories