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Mr Jack Reddaway
Research Associate
- ReddawayJ@cardiff.ac.uk
- Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Overview
I am currently a post-doctoral researcher in the labs of Dr. Timothy Wells and Dr. Sean Wyatt, studying the impact of Snord116 deletion in neuronal development. Snord116 is a non-coding RNA not expressed by individuals with Prader-Willi syndrome, a disorder characterised by hyperphagia and mild cognitive impairment.
I have expertise in high-throughput cellular imaging, 3D neuron/glia reconstruction and automated morphometric analysis which I have put to good use throughout my PhD and subsequent post-doctoral research.
My research interests focus upon the role microglia play in modifying both neuronal architecture and activity. Understanding the complex relationship between microglia and neurons is of particular importance given that dysfunctional microglia-neuronal interactions are implicated in the aetiology of many neurodevelopmental and neurodegenerative disorders.
Publication
2022
- Poppelaars, F., da Costa, M. G., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. Early-Career Complementologists (ECCO): past achievements and future directions. Molecular Immunology 151, pp. 158-165. (10.1016/j.molimm.2022.08.012)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
- Poppelaars, F., Gaya da Costa, M., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. ECCO - A new initiative to support early-career researchers in the complement field. Molecular Immunology 141, pp. 104-107. (10.1016/j.molimm.2021.11.018)
- Reddaway, J. 2022. The role of the complement system in associative learning and risk for schizophrenia. PhD Thesis, Cardiff University.
2020
- Reddaway, J. and Brydges, N. M. 2020. Enduring neuroimmunological consequences of developmental experiences: from vulnerability to resilience. Molecular and Cellular Neuroscience 109, article number: 103567. (10.1016/j.mcn.2020.103567)
- Brydges, N. and Reddaway, J. 2020. Neuroimmunological effects of early life experiences. Brain and Neuroscience Advances 4 (10.1177/2398212820953706)
2018
- Reddaway, J., Doherty, J. L., Lancaster, T., Linden, D., Walters, J. T. and Hall, J. 2018. Genomic and imaging biomarkers in schizophrenia. In: Current Topics in Behavioral Neurosciences. Berlin and Heidelberg: Springer, pp. 325-352., (10.1007/7854_2018_52)
Articles
- Poppelaars, F., da Costa, M. G., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. Early-Career Complementologists (ECCO): past achievements and future directions. Molecular Immunology 151, pp. 158-165. (10.1016/j.molimm.2022.08.012)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
- Poppelaars, F., Gaya da Costa, M., Inkeri Lokki, A., Mallah, K., Nord, D., Reddaway, J. and Schäfer, N. 2022. ECCO - A new initiative to support early-career researchers in the complement field. Molecular Immunology 141, pp. 104-107. (10.1016/j.molimm.2021.11.018)
- Reddaway, J. and Brydges, N. M. 2020. Enduring neuroimmunological consequences of developmental experiences: from vulnerability to resilience. Molecular and Cellular Neuroscience 109, article number: 103567. (10.1016/j.mcn.2020.103567)
- Brydges, N. and Reddaway, J. 2020. Neuroimmunological effects of early life experiences. Brain and Neuroscience Advances 4 (10.1177/2398212820953706)
Book sections
- Reddaway, J., Doherty, J. L., Lancaster, T., Linden, D., Walters, J. T. and Hall, J. 2018. Genomic and imaging biomarkers in schizophrenia. In: Current Topics in Behavioral Neurosciences. Berlin and Heidelberg: Springer, pp. 325-352., (10.1007/7854_2018_52)
Thesis
- Reddaway, J. 2022. The role of the complement system in associative learning and risk for schizophrenia. PhD Thesis, Cardiff University.
Biography
EDUCATION
Hodge Centre for Neuropsychiatric Immunology, Cardiff University, Cardiff, UK
PhD (Medicine) 2017 - 2021
Project title: The role of the complement system in associative leaning and risk for schizophrenia
Univeristy of Bath, Bath, UK
BSc Honors in Biochemistry 2012 – 2016
RESEARCH EXPERIENCE
School of Biosciences, Cardiff University, Cardiff, UK
Post-doctoral research associate 2021 – present
Project investigating the impact of Prader-Willi syndrome associated gene non-coding RNA Snord116 deletion upon cortical and hippocampal neuronal development.
Embark Biotech, Copenhagen Denmark
Visiting researcher 2022 - 2022
Hodge Centre for Neuropsychiatric Immunology, Cardiff University, Cardiff, UK
Phd 2017 – 2021
Project investigating immune activation following the retrieval or extinction of contextual fear memories. Developed a novel platform to assess the morphology of >10,000 microglia and predict activation status of said microglia using machine learning.
Translational Neurotrauma, Child Health, University of Arizona College of Medicine, Phoenix, AZ
University of Bath Placement Student 2014 - 2015
Honours and awards
2022 Grant Project, Embark Biotech
2022 Travel Award, Foundation for Prader-Willi Research
2022 Project Grant, Foundation for Prader-Willi Research
2021 Research Wales Innovation Grant, Welsh Government
2019 Travel Award, Hycult Biotech
2018 Travel Award, Cold Spring Harbor Laboratories