Miss Fiona Ruge

2025

• Ji, W. et al. 2025. Knockdown of claudin-8 (CLDN8) indicates a link between breast cancer cell sensitivity to chemotherapeutics and reveals a potential use of CLDN8 as a molecular diagnostic and target for therapy. International Journal of Molecular Sciences 26 (11) 5412. (10.3390/ijms26115412)
• Liu, M. et al. 2025. Noggin promotes cell proliferation through up-regulating EGFR/HER2 in pancreatic cancer cells. Cancer Genomics & Proteomics 22 (4), pp.564-574. (10.21873/cgp.20522)
• McKenna, M. et al. 2025. Human equilibrative nucleoside transporter 1 and concentrative nucleoside transporter 1 in colorectal cancer: What do we know? A systematic review. Histology and Histopathology 40 , pp.1153-1162. (10.14670/HH-18-881)

2024

• Bosanquet, D. C. et al. 2024. Sensitivity of the wound edge gene signature "WD14" in responding to clinical change: a longitudinal cohort study. International Journal of Lower Extremity Wounds 23 (3), pp.390-396. (10.1177/15347346211056786)
• Fang, Z. et al., 2024. Implication of capillary morphogenesis gene 2 (CMG2) in the disease progression and peritoneal metastasis of pancreatic cancer. Cancers 16 (16) 2893. (10.3390/cancers16162893)
• Li, A. X. et al. 2024. Metastatic Lymph Node 64 (MLN64) expression in gastric cancer, the clinical and molecular implications in drug resistance. Cancer Genomics & Proteomics 21 (1), pp.30-40. (10.21873/cgp.20427)
• Zeng, J. et al. 2024. EPLIN, a prospective oncogenic molecule with contribution to growth, migration and drug resistance in pancreatic cancer. Scientific Reports 14 (1) 30850. (10.1038/s41598-024-81485-w)

2023

• Cai, S. et al. 2023. Kinase D-interacting substrate of 220kDa is overexpressed in gastric cancer and associated with local invasion. Cancer Genomics & Proteomics 20 (6suppl), pp.735-743. (10.21873/cgp.20420)
• Fang, Z. et al. 2023. Expression of ALCAM in clinical colon cancer and relationship with patients' treatment responses. In Vivo 37 (3), pp.1117-1128. (10.21873/invivo.13187)
• Frugtniet, B. A. et al. 2023. nWASP inhibition increases wound healing via TrKb/PLCγ signalling. Biomolecules 13 (2) 379. (10.3390/biom13020379)
• Li, A. X. et al. 2023. Striatins and the STRIPAK complex partners in the clinical outcome of patients with breast cancer and responses to drug treatment. Chinese Journal of Cancer Research 35 , pp.365-385. (10.21147/j.issn.1000-9604.2023.04.04)
• Lohana, P. et al., 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12 (7) 1374. (10.3390/antiox12071374)
• Ming Yang, Y. et al., 2023. ALCAM, Activated leukocyte cell adhesion molecule, in clinical gastric cancer and patient's response to chemotherapies. Anticancer Research 43 (4), pp.1463-1475. (10.21873/anticanres.16295)
• Yang, Y. M. et al., 2023. Activated leukocyte cell adhesion molecule (alcam), a potential 'seed' and 'soil' receptor in the peritoneal metastasis of gastrointestinal cancers. International Journal of Molecular Sciences 24 (1) 876. (10.3390/ijms24010876)
• Zhuang, X. et al. 2023. Claudin-10 in the blood brain barrier function of cerebral endothelial cells and transendothelial invasion of breast cancer cells. Anticancer Research 43 (9), pp.3923-3934. (10.21873/anticanres.16580)
• Zhuang, X. et al., 2023. Expression of Claudin-9 (CLDN9) in breast cancer, the clinical significance in connection with its subcoat anchorage proteins ZO-1 and ZO-3 and impact on drug resistance. Biomedicines 11 (12) 3136. (10.3390/biomedicines11123136)

2022

• Fang, Z. et al. 2022. Sex hormone-regulated CMG2 is involved in breast and prostate cancer progression. Cancer Genomics & Proteomics 19 , pp.703-710. (10.21873/cgp.20353)
• Sui, L. et al. 2022. Death associated protein-3 (DAP3) and DAP3 binding cell death enhancer-1 (DELE1) in human colorectal cancer, and their impacts on clinical outcome and chemoresistance. International Journal of Oncology 62 (1) 7. (10.3892/ijo.2022.5455)
• Telford, E. A. et al. 2022. Hepatitis A virus cellular receptor 1 (HAVcr-1) initiates prostate cancer progression in human cells via hepatocyte growth factor (HGF)-induced changes in junctional integrity. Biomolecules 12 (2) 338. (10.3390/biom12020338)
• Zeng, J. et al. 2022. EPLIN, a putative tumour suppressor in colorectal cancer, implications in drug resistance. International Journal of Molecular Sciences 23 (23) 15232. (10.3390/ijms232315232)

2021

• Cui, Y. et al. 2021. Lead DEAD/H box helicase biomarkers with the therapeutic potential identified by integrated bioinformatic approaches in lung cancer. Computational and Structural Biotechnology Journal 19 , pp.261-278. (10.1016/j.csbj.2020.12.007)
• Xin, L. et al., 2021. SIKs suppress tumor function and regulate drug resistance in breast cancer. American Journal of Cancer Research 11 (7), pp.3537-3557.
• Yang, Y. et al. 2021. Activated leukocyte cell adhesion molecule (ALCAM)/CD166 in pancreatic cancer, a pivotal link to clinical outcome and vascular embolism. American Journal of Cancer Research 11 (12), pp.5917-5932.

2020

• Cong, Y. et al., 2020. Calcium-binding protein S100P promotes tumor progression but enhances chemosensitivity in breast cancer. Frontiers in Oncology 10 566302. (10.3389/fonc.2020.566302)
• Liu, J. et al. 2020. Increased expression of Psoriasin is correlated with poor prognosis of bladder transitional cell carcinoma by promoting invasion and proliferation. Oncology Reports 43 (2), pp.562-570. (10.3892/or.2019.7445)
• Sun, Z. et al. 2020. Noggin is associated with a poor prognosis of gastric cancer by promoting the proliferation of gastric cancer cells via the upregulation of EGFR. International Journal of Oncology 57 (3), pp.813-824. (10.3892/ijo.2020.5081)

2019

• Bosanquet, D. C. et al. 2019. Development and validation of a gene expression test to identify hard-to-heal chronic venous leg ulcers. British Journal of Surgery 106 (8), pp.1035-1042. (10.1002/bjs.11161)
• Sanders, A. et al. 2019. Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination. Oncotarget 10 (59), pp.6362-6377. (10.18632/oncotarget.27279)

2018

• Collins, R. et al. 2018. Mechanistic insights of epithelial protein lost in neoplasm in prostate cancer metastasis. International Journal of Cancer 143 (10), pp.2537-2550. (10.1002/ijc.31786)
• Harries, R. L. et al. 2018. Impact of pigment epithelium-derived factor on colorectal cancer in vitro and in vivo. Oncotarget 9 (27), pp.19192-19202. (10.18632/oncotarget.24953)

2017

• Cai, S. et al. 2017. Expression of phospholipase C isozymes in human breast cancer and their clinical significance. Oncology Reports 37 (3), pp.1707-1715. (10.3892/or.2017.5394)
• Feng, Y. et al. 2017. In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing. Scientific Reports 7 (1) 6715. (10.1038/s41598-017-06886-6)
• Li, J. et al., 2017. Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells. Oncotarget (10.18632/oncotarget.15439)
• Lopes-Bastos, B. et al., 2017. Association of breast carcinoma growth with a non-canonical axis of IFNγ/IDO1/TSP1. Oncotarget (10.18632/oncotarget.18781)
• Owen, S. et al. 2017. ShenLingLan influences the attachment and migration of ovarian cancer cells potentially through the GSK3 pathway. Medicines 7 , pp.1-11.
• Owen, S. et al. 2017. The clinical and biological implications of the focal adhesion kinase pathway in ShenLingLan mediated suppression of cellular migration of ovarian cancer cells. Journal of Cancer Research & Therapy 5 , pp.24-31. (10.14312/2052-4994.2017-5)
• Yang, W. et al., 2017. The effects of anesthetics on recurrence and metastasis of cancer, and clinical implications. World Journal of Oncology 8 (3), pp.63-70. (10.14740/wjon1031e)

2016

• Bartlett, A. et al., 2016. Potential implications of interleukin-7 in chronic wound healing. Experimental and Therapeutic Medicine 12 (1), pp.33-40. (10.3892/etm.2016.3263)
• Feng, Y. et al. 2016. Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing. International Journal of Molecular Medicine 38 (5), pp.1349-1358. (10.3892/ijmm.2016.2733)
• Jiang, W. G. et al. 2016. Effects of YangZheng XiaoJi on the migration and growth of lung cancer cells, by targeting the Hepatocyte Growth Factor Receptor-Epidermal Growth Factor Receptor (HGFR-EGFR) transactivation [Abstract]. European Journal of Cancer 51 (S3), pp.S642-S642. 3117. (10.1016/S0959-8049(16)31758-0)
• Jones, A. M. et al., 2016. The clinical significance and impact of interleukin 15 on keratinocyte cell growth and migration. International Journal of Molecular Medicine 38 , pp.679-686. (10.3892/ijmm.2016.2687)
• Liu, R. et al., 2016. Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer. International Journal of Oncology 48 (6), pp.2488-2496. (10.3892/ijo.2016.3462)
• Owen, S. et al. 2016. Heat shock protein 27 is a potential indicator for response to YangZheng XiaoJi and chemotherapy agents in cancer cells. International Journal of Oncology 49 , pp.1839-1847. (10.3892/ijo.2016.3685)
• Wang, S. et al., 2016. Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes. International Journal of Molecular Medicine 37 (2), pp.293-298. (10.3892/ijmm.2015.2434)
• Zhao, H. et al. 2016. The clinical implications of RSK1-3 in human breast cancer. Anticancer Research 36 (3), pp.1267-1274.

2015

• Glasbey, J. et al. 2015. Expression of hepatocyte growth factor-like protein in human wound tissue and its biological functionality in human keratinocytes. Biomedicines 3 (1), pp.110-123. (10.3390/biomedicines3010110)
• Jiang, W. et al. 2015. Expression of Sonic Hedgehog (SHH) in human lung cancer and the impact of YangZheng XiaoJi on SHH-mediated biological function of lung cancer cells and tumor growth.. Anticancer Research 35 (3), pp.1321-1331.
• Jiang, W. G. et al. 2015. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. Journal of Translational Medicine 13 280. (10.1186/s12967-015-0639-1)
• Jiang, W. G. et al. 2015. 3117 Effects of YangZheng XiaoJi on the migration and growth of lung cancer cells, by targeting the Hepatocyte Growth Factor Receptor-Epidermal Growth Factor Receptor (HGFR-EGFR) transactivation. European Journal of Cancer 51 (Supp 1), pp.S642. (10.1016/S0959-8049(16)31758-0)
• Liu, R. et al., 2015. Metastasis suppressor 1 (MTSS1) expression in human ovarian cancer; the impact on cellular migration and metastasis [Abstract]. Anticancer Research 35 (7), pp.4342-4342.
• Liu, R. et al., 2015. Metastasis suppressor 1 expression in human ovarian cancer: the impact on cellular migration and metastasis. International Journal of Oncology 47 (4), pp.1429-1439. (10.3892/ijo.2015.3121)
• Men, W. et al., 2015. Expression of claudins in human clear cell renal cell carcinoma. Cancer Genomics and Proteomics 12 (1), pp.1-8.
• Tan, Y. et al., 2015. Interleukin-24 (IL-24) expression and biological impact on HECV endothelial cells.. Cancer Genomics and Proteomics 12 (5), pp.243-250.
• Wang, L. et al., 2015. Interleukin 21 and its receptor play a role in proliferation, migration and invasion of breast cancer cells. Cancer Genomics and Proteomics 12 (5), pp.211-221.
• Zhang, L. et al. 2015. Reversal of pathological features of Graves' orbitopathy by activation of forkhead transcription factors, FOXOs. Journal of Clinical Endocrinology & Metabolism 101 (1), pp.114-122. (10.1210/jc.2015-2932)

2014

• Feng, Y. et al., 2014. Expression of the suppressor of cytokine signalling (SOCS) family members in chronic wound tissue. Wound Repair and Regeneration 22 (5), pp.A79-A79. (10.1111/wrr.12218)
• Ji, K. et al. 2014. Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. BMC Cancer 14 723. (10.1186/1471-2407-14-723)
• Jia, S. et al., 2014. Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration.. Anticancer Research 34 (5), pp.2185-2194.
• Jia, Y. et al., 2014. Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death. Oncology Reports 31 (1), pp.175-182. (10.3892/or.2013.2866)
• Jiang, W. G. et al. 2014. A gene expression signature that predicted the clinical outcome of chronic wounds [Abstract]. Wound Repair and Regeneration 22 (5), pp.A84-A84. (10.1111/wrr.12218)
• Jones, A. M. et al., 2014. The effect of interleukin 15 on an in vitro model of human keratinocyte cell migration in wound healing. British Journal of Surgery 101 (S4), pp.25. O86. (10.1002/bjs.9508)
• Jones, A. M. et al., 2014. The expression of interleukin 17c (IL-17c) in chronic wounds and its effect on an in vitro model of keratinocyte cell migration [Abstract]. Wound Repair and Regeneration 22 (5), pp.A85-A85. (10.1111/wrr.12218)
• Jones, A. M. et al. 2014. The effect of interleukin-17B on an in vitro model of human keratinocyte cell migration during wound healing. British Journal of Surgery 101 (s4), pp.28. O97. (10.1002/bjs.9508)
• Martin, T. A. et al. 2014. Brain-derived neurotrophic factor (bdnf) is a novel therapeutic agent in human wound healing [Abstract]. Wound Repair and Regeneration 22 (5), pp.A91. (10.1111/wrr.12218)

2013

• Jiang, W. G. et al. 2013. Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling. Oncology Reports 30 (3), pp.1405-1413. (10.3892/or.2013.2586)
• Jiang, W. G. et al. 2013. Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain. Journal of Translational Medicine 11 269. (10.1186/1479-5876-11-269)
• Sobkowicz, A. et al., 2013. Expression profile of amphyphysin I in normal and breast cancer specimens. European Journal of Cancer 49 , pp.S198-S198.

2012

• Bosanquet, D. C. et al. 2012. Expression of IL-24 and IL-24 receptors in human wound tissues and the biological implications of IL-24 on keratinocytes. Wound Repair and Regeneration 20 (6), pp.896-903. (10.1111/j.1524-475X.2012.00840.x)
• Du, P. et al., 2012. Loss of expression of growth differentiation factor-9 (GDF9) in human kidney cancer and regulation of growth and migration of kidney cancer cells by GDF9. Anticancer Research 32 (10), pp.4375-4383.
• Du, P. et al., 2012. Growth differentiation factor-9 expression is inversely correlated with an aggressive behaviour in human bladder cancer cells. International Journal of Molecular Medicine 29 (3), pp.428-434. (10.3892/ijmm.2011.858)
• Ji, K. et al. 2012. Expression of signal-induced proliferation-associated gene 1 (SIPA1), a rapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells. Cancer Genomics and Proteomics 9 (5), pp.321-327.
• Jiang, W. G. et al. 2012. Influence of interleukin-8 (IL-8) and IL-8 receptors on the migration of human keratinocytes, the role of PLC-γ and potential clinical implications. Experimental and Therapeutic Medicine 3 (2), pp.231-236. (10.3892/etm.2011.402)

2011

• Du, P. et al., 2011. Metastasis suppressor-1, MTSS1, acts as a putative tumour suppressor in human bladder cancer. Anticancer Research 31 (10), pp.3205-3212.
• Minhas, U. et al. 2011. Pattern of expression of CCN family members Cyr61, CTGF and NOV in human acute and chronic wounds. Experimental and Therapeutic Medicine 2 (4), pp.641-645. (10.3892/etm.2011.256)
• Ruge, F. et al. 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131 (3), pp.572-579. (10.1038/jid.2010.379)

2007

• Conway, K. P. et al. 2007. Hepatocyte growth factor regulation: an integral part of why wounds become chronic. Wound Repair and Regeneration 15 (5), pp.683-692. (10.1111/j.1524-475X.2007.00296.x)