![Emma Thomas-Jones](https://profiles-cardiff.imgix.net/attachments/8139?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Emma Thomas-Jones
(she/her)
- Welsh speaking
- Available for postgraduate supervision
Teams and roles for Emma Thomas-Jones
Principal Research Fellow and Deputy Director Infections Inflammation and Immunity Division
Overview
I am a Principal Research Fellow and Deputy Director for Infections, Inflammation & Immunity Research Division at the Centre for Trials Research .
My research areas are in common infections in primary care (e.g. UTI), biomarkers for infections and sepsis. I conduct evidence-based research testing the effectiveness of interventions with the aim of reducing antibiotic resistance.
I have extensive knowledge and experience in clinical trial methodology, trial conduct and research governance.
Publication
2025
- Edwards, A. et al. 2025. Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study. Health Technology Assessment 29 (1)(10.3310/RGTW5711)
- Euden, J. et al. 2025. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients: the PEACH mixed methods study. Health Technology Assessment 29 (52), pp.1-32. (10.3310/GGFF9393)
- Henley, J. et al. 2025. Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sources. BMJ Open 15 e093210. (10.1136/bmjopen-2024-093210)
- Kalra, A. et al., 2025. Does the use of intravenous immunoglobulin improve clinical outcomes in adults with autoimmune encephalitis? A systematic review. Brain and Behavior 15 (5) e70491. (10.1002/brb3.70491)
- Varley, M. et al. 2025. Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a multicentre, interventional open-label, randomised controlled trial.. BMJ Open 15 (1) e084345. (10.1136/bmjopen-2024-084345)
- Waldron, C. et al. 2025. Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT. Health Technology Assessment 29 (16)(10.3310/MBVA3675)
- Waldron, C. et al. 2025. Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. The Lancet Child & Adolescent Health 9 (2), pp.121-130. (10.1016/S2352-4642(24)00306-7)
2024
- Abel, K. et al., 2024. System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework. The Lancet Microbe 5 (5), pp.e500-e507. (10.1016/S2666-5247(24)00003-X)
- Barry, T. D. et al. 2024. The role of nurses in national TB control programs: qualitative insights from TB cohort review in Wales. Medical Research Archives 12 (12)(10.18103/mra.v12i12.6063)
- Clark, A. et al., 2024. Assessing acutely ill children in general practice using the National PEWS and LqSOFA clinical scores: a retrospective cohort study. British Journal of General Practice (10.3399/BJGP.2023.0638)
- Gwilym, B. L. et al. 2024. Long-term risk prediction after major lower limb amputation: 1-year results of the PERCEIVE study. BJS Open 8 (1) zrad135. (10.1093/bjsopen/zrad135)
- Ingram, J. R. et al. 2024. Treatment of hidradenitis suppurativa evaluation study (THESEUS): a prospective cohort study. British Journal of Dermatology 190 (3), pp.382-391. (10.1093/bjd/ljad388)
- Lowe, J. et al. 2024. Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial. The Lancet Respiratory Medicine 12 (8), pp.608-618. (10.1016/S2213-2600(24)00079-1)
- Milosevic, S. et al. 2024. Rehabilitation experiences following major lower limb amputation due to complications of vascular disease: a UK qualitative study. Disability and Rehabilitation 46 (26), pp.6477-6486. (10.1080/09638288.2024.2329747)
- Sandoe, J. A. T. et al., 2024. A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19. Journal of Antimicrobial Chemotherapy 79 (11), pp.2792-2800. dkae246. (10.1093/jac/dkae246)
- Webb, E. J. D. et al., 2024. The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study. Journal of Antimicrobial Chemotherapy 79 (8), pp.1831-1842. dkae167. (10.1093/jac/dkae167)
- Webb, E. J. D. et al., 2024. Evidence of quality of life for hospitalised patients with COVID-19: a scoping review. Health Technology Assessment 29 (52), pp.33-56. (10.3310/ATPR4281)
2023
- Henley, J. et al. 2023. Developing a model for decision-making around antibiotic prescribing for patients with COVID-19 pneumonia in acute NHS hospitals during the first wave of the COVID-19 pandemic: Qualitative results from the Procalcitonin Evaluation of Antibiotic use in COVID-19 Hospitalised patients (PEACH Study). BMJ Open 13 (12) e077117. (10.1136/bmjopen-2023-077117)
- Ingram, J. R. et al. 2023. Treatment of hidradenitis suppurativa evaluation study: the THESEUS prospective cohort study. Health Technology Assessment 27 30. (10.3310/HWNM2189)
- Leighton, P. et al., 2023. Research priorities in the management of Hidradenitis Suppurativa [Research Letter]. British Journal of Dermatology 189 (3), pp.343-345. (10.1093/bjd/ljad152)
- Schoenbuchner, S. M. et al. 2023. Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials 24 (1) 364. (10.1186/s13063-022-06956-9)
2022
- Abbott, R. A. et al., 2022. Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study). Clinical and Experimental Dermatology 47 (5), pp.882-888. (10.1111/ced.15037)
- Allen, D. et al. 2022. Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study. Health and Social Care Delivery Research 10 (1)(10.3310/CHCK4556)
- Chatoo, S. A. et al., 2022. Antibiotic prescribing in hospitalized patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review. Presented at: BSAC Spring Conference 2022 10 - 11 May 2022. Vol. 4.Vol. S.2. (10.1093/jacamr/dlac053.012)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study. Presented at: Infection 2021: BSAC Winter Conference Virtual 9-10 December 2021. Vol. 4.Vol. 1. (10.1093/jacamr/dlac004.013)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH): protocol for a retrospective observational study. Methods and Protocols 5 (6) 95. (10.3390/mps5060095)
- Euden, J. et al. 2022. PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open 12 (6) e063424. (10.1136/bmjopen-2022-063424)
- Gillespie, D. et al. 2022. Associations with post-consultation health-status in primary care managed acute exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2022 (17), pp.383-394. (10.2147/COPD.S340710)
- Gwilym, B. L. et al., 2022. Short-term risk prediction after major lower limb amputation: PERCEIVE study. BJS Open 109 (12), pp.1300-1311. (10.1093/bjs/znac309)
- Lenihan, R. A. F. et al., 2022. Mid-regional pro-adrenomedullin in combination with pediatric early warning scores for risk stratification of febrile children presenting to the emergency department: secondary analysis of a nonprespecified United Kingdom cohort study. Pediatric Critical Care Medicine 23 (12), pp.980-989. (10.1097/PCC.0000000000003075)
- Milosevic, S. et al. 2022. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation: a collaboratiVE study (PERCEIVE)—protocol for the PERCEIVE qualitative study. BMJ Open 12 (1) e053159. (10.1136/bmjopen-2021-053159)
- Totty, J. P. et al., 2022. Use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK: a national, multispeciality survey of clinicians. Clinical and Experimental Dermatology 47 (5), pp.957-959. (10.1111/ced.15075)
- Waldron, C. et al. 2022. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial. BMJ Open 12 (1) e047490. (10.1136/bmjopen-2020-047490)
2021
- Gwilym, B. et al., 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study. Presented at: National Research Collaborative Meeting 2020 (NRCM 2020) Virtual 19 November - 10 December 2020. Vol. 5.Vol. Supple. Wiley(10.1093/bjsopen/zrab032.089)
- Gwilym, B. L. et al., 2021. The PERCEIVE quantitative study: PrEdiction of Risk and Communication of outcome following major lower-limb amputation: protocol for a collaboratiVE study. BJS Open 5 (6) zrab118. (10.1093/bjsopen/zrab118)
- Milosevic, S. et al. 2021. Conducting invasive urodynamics in primary care: Qualitative interview study examining experiences of patients and healthcare professionals. Diagnostic and Prognostic Research 5 10. (10.1186/s41512-021-00100-y)
- Milosevic, S. et al. 2021. Managing LUTS in primary care: qualitative study of GPs’ and patients’ experiences. British Journal of General Practice 71 (710), pp.e685-e692. (10.3399/BJGP.2020.1043)
- Milosevic, S. et al. 2021. Exploring patients’ experiences of analgesia after major lower limb amputation: A qualitative study. BMJ Open 11 e054618. (10.1136/bmjopen-2021-054618)
- Phillips, R. et al., 2021. Cohort profile: The UK COVID-19 Public Experiences (COPE) prospective longitudinal mixed-methods study of health and well-being during the SARSCoV2 coronavirus pandemic. PLoS ONE 16 (10) e0258484. (10.1371/journal.pone.0258484)
- Powell, N. et al., 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10 (5) 516. (10.3390/antibiotics10050516)
- Preece, R. et al., 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62 (1), pp.127-135. (10.1016/j.ejvs.2021.02.038)
- Richards, O. et al., 2021. Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS. Antibiotics 10 (11) 1425. (10.3390/antibiotics10111425)
2020
- Ambler, G. K. et al., 2020. Prognostic risk modelling for patients undergoing major lower limb amputation: an analysis of the UK National Vascular Registry. European Journal of Vascular and Endovascular Surgery 59 (4), pp.606-613. (10.1016/j.ejvs.2019.12.006)
- Pell, B. et al. 2020. PRImary care Management of lower Urinary tract Symptoms in men: protocol for development and validation of a diagnostic and clinical decision support tool (the PriMUS study). BMJ 10 (6) e037634. (10.1136/bmjopen-2020-037634)
2019
- Brookes-Howell, L. et al. 2019. Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study. BJGP Open 3 (2) 18X101630. (10.3399/bjgpopen18X101630)
2018
- Bosanquet, D. C. et al. 2018. Major lower limb amputation audit – introduction and implementation of a multimodal perioperative pain management guideline. British Journal of Pain 12 (4), pp.257-258. (10.1177/2049463718800736)
- Butler, C. C. et al. 2018. Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness. British Journal of General Practice 68 (669), pp.e268-e278. (10.3399/bjgp18X695285)
- Francis, N. A. et al. 2018. Oral steroids for hearing loss associated with otitis media with effusion in children aged 2 8 years: the OSTRICH RCT. Health Technology Assessment 22 (61)(10.3310/hta22610)
- Francis, N. A. et al. 2018. Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial. Lancet 392 (10147), pp.557-568. (10.1016/S0140-6736(18)31490-9)
- Gillespie, D. et al. 2018. Use of co-primary outcomes for trials of antimicrobial stewardship interventions. Lancet Infectious Diseases 18 (6), pp.595-597. (10.1016/S1473-3099(18)30289-5)
- Ingram, J. et al. 2018. Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study). Diabetic Medicine 35 (2), pp.255-261. (10.1111/dme.13431)
- Prout, H. C. et al. 2018. Patient understanding and acceptability of an early lung cancer diagnosis trial: a qualitative study. Trials 19 419. (10.1186/s13063-018-2803-4)
- Santer, M. et al., 2018. Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT. Health Technology Assessment 22 (57)(10.3310/hta22570)
- Santer, M. et al., 2018. Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness. BMJ 361 k1332. (10.1136/bmj.k1332)
- Stuart, B. et al., 2018. Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: Experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema). Trials 19 582.
2017
- Ambler, G. K. et al. 2017. Development of a core outcome set for studies involving patients undergoing major lower limb amputation for peripheral arterial disease: study protocol for a systematic review and identification of a core outcome set using a Delphi survey. Trials 18 (1) 628. (10.1186/s13063-017-2358-9)
- Bosanquet, D. C. et al., 2017. Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): study protocol for a randomised controlled pilot study. Trials 18 629. (10.1186/s13063-017-2357-x)
- Butler, C. C. et al. 2017. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. British Journal of General Practice 67 (665), pp.e830-e841. (10.3399/bjgp17X693641)
- Francis, N. A. et al. 2017. Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine 15 (2), pp.124-130. (10.1370/afm.2038)
- Hollingworth, W. et al., 2017. The diagnosis of urinary tract infection in young children (DUTY) study clinical rule: economic evaluation. Value in Health 20 (4), pp.556-566. (10.1016/j.jval.2017.01.003)
- Shepherd, V. et al. 2017. Impact of a deferred recruitment model in a randomised controlled trial in primary care (CREAM study). Trials 18 (1) 533. (10.1186/s13063-017-2284-x)
2016
- Francis, N. A. et al. 2016. A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study. Health Technology Assessment 20 (19), pp.1-84. (10.3310/hta20190)
- Glover, G. W. et al., 2016. Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest - an analysis of the TTM trial data. Critical care (London, England) 20 (1) 381. (10.1186/s13054-016-1552-6)
- Waldron, C. et al. 2016. Oral Steroids for the Resolution of Otitis Media with Effusion (OME) in Children (OSTRICH): study protocol for a randomised controlled trial. Trials 17 115. (10.1186/s13063-016-1236-1)
2015
- Butler, C. C. et al. 2015. Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery. British Journal of General Practice 65 (633), pp.e217-e223. (10.3399/bjgp15X684361)
- Gillespie, D. et al. 2015. Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents. Age and Ageing 44 (5), pp.853-860. (10.1093/ageing/afv072)
2014
- Bates, J. et al., 2014. Point of care testing for urinary tract infection in primary care (POETIC): protocol for a randomised controlled trial of the clinical and cost effectiveness of FLEXICULT (TM) informed management of uncomplicated UTI in primary care. BMC Family Practice 15 , pp.-. 187. (10.1186/s12875-014-0187-4)
2013
- Bates, J. et al., 2013. Effects of an optimised POCT guided diagnostic and treatment strategy for symptoms of uncomplicated UTI on use of appropriate antibiotics and uptake into primary care practice. [Abstract]. Trials 14 (S1), pp.-. P10. (10.1186/1745-6215-14-S1-P10)
- Waldron, C. et al. 2013. Recruitment to diagnosis of urinary tract infections in young children (DUTY) study: an evaluation of the successful methods used in a primary care, prospective cohort study. [Abstract]. Trials 14 (S1), pp.-. P37. (10.1186/1745-6215-14-S1-P37)
2012
- Robling, M. R. et al. 2012. The effect of the Talking Diabetes consulting skills intervention on glycaemic control and quality of life in children with type 1 diabetes: cluster randomised controlled trial (DEPICTED study). British Medical Journal 344 e2359. (10.1136/bmj.e2359)
2011
- Gregory, J. W. et al. 2011. Development and evaluation by a cluster randomised trial of a psychosocial intervention in children and teenagers experiencing diabetes: The DEPICTED study. Health Technology Assessment 15 (29), pp.1-202. (10.3310/hta15290)
Articles
- Abbott, R. A. et al., 2022. Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study). Clinical and Experimental Dermatology 47 (5), pp.882-888. (10.1111/ced.15037)
- Abel, K. et al., 2024. System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework. The Lancet Microbe 5 (5), pp.e500-e507. (10.1016/S2666-5247(24)00003-X)
- Allen, D. et al. 2022. Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study. Health and Social Care Delivery Research 10 (1)(10.3310/CHCK4556)
- Ambler, G. K. et al. 2017. Development of a core outcome set for studies involving patients undergoing major lower limb amputation for peripheral arterial disease: study protocol for a systematic review and identification of a core outcome set using a Delphi survey. Trials 18 (1) 628. (10.1186/s13063-017-2358-9)
- Ambler, G. K. et al., 2020. Prognostic risk modelling for patients undergoing major lower limb amputation: an analysis of the UK National Vascular Registry. European Journal of Vascular and Endovascular Surgery 59 (4), pp.606-613. (10.1016/j.ejvs.2019.12.006)
- Barry, T. D. et al. 2024. The role of nurses in national TB control programs: qualitative insights from TB cohort review in Wales. Medical Research Archives 12 (12)(10.18103/mra.v12i12.6063)
- Bates, J. et al., 2013. Effects of an optimised POCT guided diagnostic and treatment strategy for symptoms of uncomplicated UTI on use of appropriate antibiotics and uptake into primary care practice. [Abstract]. Trials 14 (S1), pp.-. P10. (10.1186/1745-6215-14-S1-P10)
- Bates, J. et al., 2014. Point of care testing for urinary tract infection in primary care (POETIC): protocol for a randomised controlled trial of the clinical and cost effectiveness of FLEXICULT (TM) informed management of uncomplicated UTI in primary care. BMC Family Practice 15 , pp.-. 187. (10.1186/s12875-014-0187-4)
- Bosanquet, D. C. et al. 2018. Major lower limb amputation audit – introduction and implementation of a multimodal perioperative pain management guideline. British Journal of Pain 12 (4), pp.257-258. (10.1177/2049463718800736)
- Bosanquet, D. C. et al., 2017. Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): study protocol for a randomised controlled pilot study. Trials 18 629. (10.1186/s13063-017-2357-x)
- Brookes-Howell, L. et al. 2019. Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study. BJGP Open 3 (2) 18X101630. (10.3399/bjgpopen18X101630)
- Butler, C. C. et al. 2017. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. British Journal of General Practice 67 (665), pp.e830-e841. (10.3399/bjgp17X693641)
- Butler, C. C. et al. 2018. Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness. British Journal of General Practice 68 (669), pp.e268-e278. (10.3399/bjgp18X695285)
- Butler, C. C. et al. 2015. Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery. British Journal of General Practice 65 (633), pp.e217-e223. (10.3399/bjgp15X684361)
- Clark, A. et al., 2024. Assessing acutely ill children in general practice using the National PEWS and LqSOFA clinical scores: a retrospective cohort study. British Journal of General Practice (10.3399/BJGP.2023.0638)
- Edwards, A. et al. 2025. Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study. Health Technology Assessment 29 (1)(10.3310/RGTW5711)
- Euden, J. et al. 2025. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients: the PEACH mixed methods study. Health Technology Assessment 29 (52), pp.1-32. (10.3310/GGFF9393)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH): protocol for a retrospective observational study. Methods and Protocols 5 (6) 95. (10.3390/mps5060095)
- Euden, J. et al. 2022. PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open 12 (6) e063424. (10.1136/bmjopen-2022-063424)
- Francis, N. A. et al. 2016. A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study. Health Technology Assessment 20 (19), pp.1-84. (10.3310/hta20190)
- Francis, N. A. et al. 2018. Oral steroids for hearing loss associated with otitis media with effusion in children aged 2 8 years: the OSTRICH RCT. Health Technology Assessment 22 (61)(10.3310/hta22610)
- Francis, N. A. et al. 2018. Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial. Lancet 392 (10147), pp.557-568. (10.1016/S0140-6736(18)31490-9)
- Francis, N. A. et al. 2017. Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine 15 (2), pp.124-130. (10.1370/afm.2038)
- Gillespie, D. et al. 2022. Associations with post-consultation health-status in primary care managed acute exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2022 (17), pp.383-394. (10.2147/COPD.S340710)
- Gillespie, D. et al. 2018. Use of co-primary outcomes for trials of antimicrobial stewardship interventions. Lancet Infectious Diseases 18 (6), pp.595-597. (10.1016/S1473-3099(18)30289-5)
- Gillespie, D. et al. 2015. Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents. Age and Ageing 44 (5), pp.853-860. (10.1093/ageing/afv072)
- Glover, G. W. et al., 2016. Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest - an analysis of the TTM trial data. Critical care (London, England) 20 (1) 381. (10.1186/s13054-016-1552-6)
- Gregory, J. W. et al. 2011. Development and evaluation by a cluster randomised trial of a psychosocial intervention in children and teenagers experiencing diabetes: The DEPICTED study. Health Technology Assessment 15 (29), pp.1-202. (10.3310/hta15290)
- Gwilym, B. L. et al. 2024. Long-term risk prediction after major lower limb amputation: 1-year results of the PERCEIVE study. BJS Open 8 (1) zrad135. (10.1093/bjsopen/zrad135)
- Gwilym, B. L. et al., 2022. Short-term risk prediction after major lower limb amputation: PERCEIVE study. BJS Open 109 (12), pp.1300-1311. (10.1093/bjs/znac309)
- Gwilym, B. L. et al., 2021. The PERCEIVE quantitative study: PrEdiction of Risk and Communication of outcome following major lower-limb amputation: protocol for a collaboratiVE study. BJS Open 5 (6) zrab118. (10.1093/bjsopen/zrab118)
- Henley, J. et al. 2025. Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sources. BMJ Open 15 e093210. (10.1136/bmjopen-2024-093210)
- Henley, J. et al. 2023. Developing a model for decision-making around antibiotic prescribing for patients with COVID-19 pneumonia in acute NHS hospitals during the first wave of the COVID-19 pandemic: Qualitative results from the Procalcitonin Evaluation of Antibiotic use in COVID-19 Hospitalised patients (PEACH Study). BMJ Open 13 (12) e077117. (10.1136/bmjopen-2023-077117)
- Hollingworth, W. et al., 2017. The diagnosis of urinary tract infection in young children (DUTY) study clinical rule: economic evaluation. Value in Health 20 (4), pp.556-566. (10.1016/j.jval.2017.01.003)
- Ingram, J. et al. 2018. Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study). Diabetic Medicine 35 (2), pp.255-261. (10.1111/dme.13431)
- Ingram, J. R. et al. 2023. Treatment of hidradenitis suppurativa evaluation study: the THESEUS prospective cohort study. Health Technology Assessment 27 30. (10.3310/HWNM2189)
- Ingram, J. R. et al. 2024. Treatment of hidradenitis suppurativa evaluation study (THESEUS): a prospective cohort study. British Journal of Dermatology 190 (3), pp.382-391. (10.1093/bjd/ljad388)
- Kalra, A. et al., 2025. Does the use of intravenous immunoglobulin improve clinical outcomes in adults with autoimmune encephalitis? A systematic review. Brain and Behavior 15 (5) e70491. (10.1002/brb3.70491)
- Leighton, P. et al., 2023. Research priorities in the management of Hidradenitis Suppurativa [Research Letter]. British Journal of Dermatology 189 (3), pp.343-345. (10.1093/bjd/ljad152)
- Lenihan, R. A. F. et al., 2022. Mid-regional pro-adrenomedullin in combination with pediatric early warning scores for risk stratification of febrile children presenting to the emergency department: secondary analysis of a nonprespecified United Kingdom cohort study. Pediatric Critical Care Medicine 23 (12), pp.980-989. (10.1097/PCC.0000000000003075)
- Lowe, J. et al. 2024. Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial. The Lancet Respiratory Medicine 12 (8), pp.608-618. (10.1016/S2213-2600(24)00079-1)
- Milosevic, S. et al. 2022. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation: a collaboratiVE study (PERCEIVE)—protocol for the PERCEIVE qualitative study. BMJ Open 12 (1) e053159. (10.1136/bmjopen-2021-053159)
- Milosevic, S. et al. 2021. Conducting invasive urodynamics in primary care: Qualitative interview study examining experiences of patients and healthcare professionals. Diagnostic and Prognostic Research 5 10. (10.1186/s41512-021-00100-y)
- Milosevic, S. et al. 2021. Managing LUTS in primary care: qualitative study of GPs’ and patients’ experiences. British Journal of General Practice 71 (710), pp.e685-e692. (10.3399/BJGP.2020.1043)
- Milosevic, S. et al. 2021. Exploring patients’ experiences of analgesia after major lower limb amputation: A qualitative study. BMJ Open 11 e054618. (10.1136/bmjopen-2021-054618)
- Milosevic, S. et al. 2024. Rehabilitation experiences following major lower limb amputation due to complications of vascular disease: a UK qualitative study. Disability and Rehabilitation 46 (26), pp.6477-6486. (10.1080/09638288.2024.2329747)
- Pell, B. et al. 2020. PRImary care Management of lower Urinary tract Symptoms in men: protocol for development and validation of a diagnostic and clinical decision support tool (the PriMUS study). BMJ 10 (6) e037634. (10.1136/bmjopen-2020-037634)
- Phillips, R. et al., 2021. Cohort profile: The UK COVID-19 Public Experiences (COPE) prospective longitudinal mixed-methods study of health and well-being during the SARSCoV2 coronavirus pandemic. PLoS ONE 16 (10) e0258484. (10.1371/journal.pone.0258484)
- Powell, N. et al., 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10 (5) 516. (10.3390/antibiotics10050516)
- Preece, R. et al., 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62 (1), pp.127-135. (10.1016/j.ejvs.2021.02.038)
- Prout, H. C. et al. 2018. Patient understanding and acceptability of an early lung cancer diagnosis trial: a qualitative study. Trials 19 419. (10.1186/s13063-018-2803-4)
- Richards, O. et al., 2021. Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS. Antibiotics 10 (11) 1425. (10.3390/antibiotics10111425)
- Robling, M. R. et al. 2012. The effect of the Talking Diabetes consulting skills intervention on glycaemic control and quality of life in children with type 1 diabetes: cluster randomised controlled trial (DEPICTED study). British Medical Journal 344 e2359. (10.1136/bmj.e2359)
- Sandoe, J. A. T. et al., 2024. A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19. Journal of Antimicrobial Chemotherapy 79 (11), pp.2792-2800. dkae246. (10.1093/jac/dkae246)
- Santer, M. et al., 2018. Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT. Health Technology Assessment 22 (57)(10.3310/hta22570)
- Santer, M. et al., 2018. Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness. BMJ 361 k1332. (10.1136/bmj.k1332)
- Schoenbuchner, S. M. et al. 2023. Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials 24 (1) 364. (10.1186/s13063-022-06956-9)
- Shepherd, V. et al. 2017. Impact of a deferred recruitment model in a randomised controlled trial in primary care (CREAM study). Trials 18 (1) 533. (10.1186/s13063-017-2284-x)
- Stuart, B. et al., 2018. Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: Experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema). Trials 19 582.
- Totty, J. P. et al., 2022. Use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK: a national, multispeciality survey of clinicians. Clinical and Experimental Dermatology 47 (5), pp.957-959. (10.1111/ced.15075)
- Varley, M. et al. 2025. Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a multicentre, interventional open-label, randomised controlled trial.. BMJ Open 15 (1) e084345. (10.1136/bmjopen-2024-084345)
- Waldron, C. et al. 2025. Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT. Health Technology Assessment 29 (16)(10.3310/MBVA3675)
- Waldron, C. et al. 2025. Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. The Lancet Child & Adolescent Health 9 (2), pp.121-130. (10.1016/S2352-4642(24)00306-7)
- Waldron, C. et al. 2013. Recruitment to diagnosis of urinary tract infections in young children (DUTY) study: an evaluation of the successful methods used in a primary care, prospective cohort study. [Abstract]. Trials 14 (S1), pp.-. P37. (10.1186/1745-6215-14-S1-P37)
- Waldron, C. et al. 2022. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial. BMJ Open 12 (1) e047490. (10.1136/bmjopen-2020-047490)
- Waldron, C. et al. 2016. Oral Steroids for the Resolution of Otitis Media with Effusion (OME) in Children (OSTRICH): study protocol for a randomised controlled trial. Trials 17 115. (10.1186/s13063-016-1236-1)
- Webb, E. J. D. et al., 2024. The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study. Journal of Antimicrobial Chemotherapy 79 (8), pp.1831-1842. dkae167. (10.1093/jac/dkae167)
- Webb, E. J. D. et al., 2024. Evidence of quality of life for hospitalised patients with COVID-19: a scoping review. Health Technology Assessment 29 (52), pp.33-56. (10.3310/ATPR4281)
Conferences
- Chatoo, S. A. et al., 2022. Antibiotic prescribing in hospitalized patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review. Presented at: BSAC Spring Conference 2022 10 - 11 May 2022. Vol. 4.Vol. S.2. (10.1093/jacamr/dlac053.012)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study. Presented at: Infection 2021: BSAC Winter Conference Virtual 9-10 December 2021. Vol. 4.Vol. 1. (10.1093/jacamr/dlac004.013)
- Gwilym, B. et al., 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study. Presented at: National Research Collaborative Meeting 2020 (NRCM 2020) Virtual 19 November - 10 December 2020. Vol. 5.Vol. Supple. Wiley(10.1093/bjsopen/zrab032.089)
Research
Research Interests
- Infections, Inflammation and Immunity
- Biomarkers and Point of Care Devices
- Sepsis
- Antimicrobial stewardship
Grants
I have been awarded >£32m in grant funding across 24 grants, including £2m as co-chief investigator.
Research grants (most recent first), with my specific role in bold:
2024
- Abbott and Thomas-Jones, et al. EXamining antibiotics for ulCerated skIn cancer Surgical Excision (EXCISE). NIHR HTA. £1.5M (Co-Chief Investigator).
- Roberts, Roland, and Cathie et al. A randomised trial of aminophylline, magnesium sulfate or salbutamol intravenous therapy for acute severe asthma in children and young people. NIHR HTA. £2.3M (Co-applicant, Lead for Trial Management).
2023
- Harding, et al. IntraVESical Preparations for Recurrent Urinary TrAct Infection Prevention (The VESPER Trial): a multi-arm, multi-site open label randomised superiority trial. NIHR HTA. £2.1M (CTR Principal Investigator)
- Kotecha, et al. Bacterial mucosal immunotherapy for prevention of wheeze in preterm born infants (BALLOON Trial). NIHR/MRC EME. £2.7M (Co-applicant).
- Pallmann P and Carrol E, et al. Platform randomised evaluation of clinical outcomes using novel technologies to optimise antimicrobial therapy (PROTECT). NIHR HTA. £205K (CTR Principal Investigator).
2021
- Mark Tuthill et al. RAPID PROTECTION: an adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus AztraZeneca, £3.1M (CTR principal investigator).
2020
- Sandoe J and Carrol ED, et al. Procalcitonin: Evaluation of Antibiotic use in COVID-19 Hospitalised patients (The PEACH Study). NIHR COVID Rapid Recovery Call. £731,859. (CTR Principal Investigator)
- Phillips R, Thomas-Jones E, et al. COVID-19 public experiences in Wales: A longitudinal mixed-methods study of attitudes, beliefs, and behaviour in response to the coronavirus pandemic (COPE Cymru). Ser Cymru Call for COVID-19 Research. £130K. (Co-chief Investigator).
- Bosanquet D, et al. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation- a collaboratiVE study (PERCEIVE). Health and Care Research Wales (Research for Patient and Public Benefit RfPPB), £229,225 (Co-applicant).
- Carrol ED, Thomas-Jones E, et al. - MR-Pro-adrenomedullin (MR-proADM) and ImmunoExpert Evaluation of procalcitonin-guided antibiotic duration in Children with Infection for Stratification of Effectiveness (PRECISE). NIHR Efficacy and Mechanism Evaluation (EME). £385,451. (Co-Chief Investigator).
- Edwards AE, et al. Health Care Research Wales (Welsh Government Infrastructure Funding). PRIME Centre Infrastructure renewal. £4.8M (Co-Applicant).
2019
- Hood K, et al. Health and Care Research Wales. Centre for Trials Research Infrastructure renewal. £2.5M (Co-applicant).
- Solomon T, et al. Enceph-IG - Intravenous Immunoglobulin in Autoimmune Encephalitis in Adults: A Randomised Double-Blind Placebo-Controlled Trial. NIHR/MRC EME. £2.4M (CTR Principal Investigator).
- Kotecha S, et al. AZithromycin ThErapy for Chronic lung disease (AZTEC): A randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. NIHR HTA. £2,518,929. (Co-applicant).
- French N, et al. PROcalcitonin and NEWS evaluation for Timely identification of sepsis and Optimal use of antibiotics in the Emergency Department (PRONTO). NIHR HTA. £1,964,286. (CTR Principal Investigator).
2018
- Ingram J, et al. Management of Hidrandenitis Suppurativa (THESEUS). NIHR HTA. £629,000. (CTR Principal Investigator).
2017
- Carrol ED, et al. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH). NIHR HTA. £1.5M. (CTR Principal Investigator).
- Edwards AE, Harding C. et al. Primary care management of lower urinary tract symptoms in men: Development and validation of a diagnostic and decision-making aid (PRIMUS). NIHR HTA. £1.6M. (CTR Principal Investigator).
2016
- Twine C, Bosanquet, D, et al. A phase II clinical trial examining the use of perineural catheters after major lower limb amputation in adults with critical limb ischaemia (PLACEMENT Feasibility Study). Health and Care Research Wales (RfPPB). £210,552 (CTR Principal Investigator).
2015
· Clinical Trials Unit Infrastructure funding. Health and Care Research Wales. £2.9 M. (Co-applicant).
2014
· Powell C, et al. Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance (PUMA). NIHR Health Service & Delivery Research (HS&DR) £1.9 M. (Co-applicant).
2013
· Ingram J, et al. Supporting antibiotic prescribing decisions for diabetic foot ulcer infections: an investigation of the diagnostic accuracy of inflammatory biomarkers. Health and Care Research Wales RfPPB £195,920. (Co-applicant).
2011
· Butler C, et al. Oral Steroids for the Resolution of otitis media with effusion (OME) In Children (OSTRICH) NIHR HTA£1.3 M. (Co-applicant).
Biography
Education and qualifications
- 1997: PhD "The estimation of circulating plasma volume using fluorescently labelled hydroxyethyl starch”. School of Molecular and Medical Biosciences, University of Wales, Cardiff.
- 1993: BSc in Biochemistry and Physiology (Joint Honours), University of Wales, College of Cardiff.
Career overview
- 2022 - present: Principal Research Fellow, Centre for Trials Research, Cardiff University.
- 2020 - present: Deputy Director of Infections, Inflammation and Immunity Trials, Centre for Trials Research, Cardiff University.
- 2019 - 2022: Senior Research Fellow, Centre for Trials Research, Cardiff University.
- 2011 - 2019: Research Fellow (Senior Trial Manager), Centre for Trials Research, Cardiff University.
- 2010 – 2011: Acting Research Fellow (Senior Trial Manager), South East Wales Trials Unit, Cardiff University
- 2009 – 2010: Research Associate (Trial Manager), South East Wales Trials Unit, Cardiff University.
- 1999 – 2008: Senior Scientist, Molecular Light Technology (GenProbe Inc.), Cardiff
- 1997 – 1999: Research Associate, School of Biosciences, University of Wales, Cardiff.
External Committees
- Current board member for NIHR Programme Grant for Applied Research Committee
- Previous board member for the Health and Care Research Wales Research for Patient and Public Benefit (RfPPB) panel (2018 to 2024)
- Previous associate board member for NIHR HTA Commissioning Committee (2023-2024)
- Previous independent member for several TSCs
Professional memberships
- Member of the Society for Academic Primary Care (SAPC).
- Member of BSAC
Committees and reviewing
- Grant reviewer for the Health and Care Research Wales Research for Patient and Public Benefit (RfPPB), NIHR School of Primary Care Research
- Grant reviewer for Cardiff Univeristy MRC Confidence in Concept and MRC Proximity to Discovery funding awards
- Member of Cwm Taf Research and Development Committee
- Member of HCRW Primary Care Research Strategy Committee
- Steering committee member for South West Hub Research Forum
- Journal reviewer for the BMJ, BMJ Open, British Journal of General Practice, Trials, and BMC Series (Infectious Diseases, Family Practice).
Supervisions
I am interested in supervising PhD students in the areas of:
- Biomarker guided antimicrobial decision making
- Antimicrobial resistance
- Clinical trials methodology
Contact Details
[email protected]
+44 29206 87520
Neuadd Meirionnydd, Floor 7th Floor, Room 708F, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
+44 29206 87520
Neuadd Meirionnydd, Floor 7th Floor, Room 708F, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
