Professor Peter Watson

(he/him)

2024

• Majer, J. et al. 2024. Multimodal imaging of a liver-on-a-chip model using labelled and label-free optical microscopy techniques †. Lab on a Chip 24(19), pp. 4594-4608. (10.1039/d4lc00504j)

2023

• Slesiona, N., Payne, L., Pope, I., Borri, P., Langbein, W. and Watson, P. 2023. Correlative extinction and single fluorophore bleaching microscopy for ligand quantification on gold nanoparticles. Advanced Materials Interfaces 10(24), article number: 2300568. (10.1002/admi.202300568)
• Recchia, M. E. et al. 2023. Multiphoton microscopy and ultrafast spectroscopy: Imaging meets quantum (MUSIQ) roadmap.

2022

• Sayers, E. J., Palmer, I., Hope, L., Hope, P., Watson, P. and Jones, A. T. 2022. Fluid-phase endocytosis and lysosomal degradation of bovine lactoferrin in lung cells. Pharmaceutics 14(4), article number: 855. (10.3390/pharmaceutics14040855)

2021

• Boorman, D., Pope, I., Masia, F., Langbein, W., Hood, S., Borri, P. and Watson, P. 2021. Hyperspectral CARS microscopy and quantitative unsupervised analysis of deuterated and non-deuterated fatty acid storage in human cells. The Journal of Chemical Physics 155(22), article number: 224202. (10.1063/5.0065950)
• Boorman, D., Pope, I., Masia, F., Watson, P., Borri, P. and Langbein, W. 2021. Quantification of the nonlinear susceptibility of the hydrogen and deuterium stretch vibration for biomolecules in coherent Raman microspectroscopy. Journal of Raman Spectroscopy 52(9), pp. 1540-1551. (10.1002/jrs.6164)
• Herkert, E. et al. 2021. Roadmap on bio-nano-photonics. Journal of Optics 23(7), article number: 73001. (10.1088/2040-8986/abff94)

2020

• Giannakopoulou, N. et al. 2020. Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells. Nanoscale 12(7), pp. 4622-4635. (10.1039/C9NR08512B)

2019

• Lorenzer, C. et al. 2019. Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics 141, pp. 37-50. (10.1016/j.ejpb.2019.05.015)
• Jones, S., Caws, T., Hayes, A., Marsh Durban, V., Corteling, R. and Watson, P. 2019. Characterizing the cellular uptake of neural stem-cell derived exosomes using live-cell imaging techniques. Presented at: ISEV2019 Annual Meeting, Kyoto, Japan, 24-28 April 2019, Vol. 8. Vol. sup1. Wiley pp. IP12., (10.1080/20013078.2019.1593587)
• Borri, P., Giannakopoulou, N., Zoriniants, G., Pope, I., Masia, F., Watson, P. and Langbein, W. 2019. Imaging and tracking single plasmonic nanoparticles in 3D background-free with four-wave mixing interferometry. Presented at: SPIE BIOS, San Francisco, CA, USA, 2-7 February 2019Proceedings Volume 10894, Plasmonics in Biology and Medicine XVI, Vol. 108940. Society of Photo-Optical Instrumentation Engineers (SPIE) pp. 34., (10.1117/12.2507618)
• Boorman, D., Pope, I., Langbein, W., Hood, S., Borri, P. and Watson, P. 2019. Optimisation of multimodal coherent anti-Stokes Raman scattering microscopy for the detection of isotope-labelled molecules. Presented at: SPIE BIOS, San Francisco, CA, USA, 2-7 February 2019Proceedings Volume 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, Vol. 108900. Society of Photo-Optical Instrumentation Engineers (SPIE) pp. 4., (10.1117/12.2509280)

2018

• Pope, I. et al. 2018. Coherent Raman Scattering microscopy: technology developments and biological applications. Presented at: 20th International Conference on Transparent Optical Networks (ICTON), Bucharest, Romania, 1-5 Jul 201820th International Conference on Transparent Optical Networks (ICTON). IEEE, (10.1109/ICTON.2018.8473706)
• He, L., Sayers, E. J., Watson, P. and Jones, A. T. 2018. Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates. Scientific Reports 8(1), article number: 7318. (10.1038/s41598-018-25600-8)
• Masia, F., Pope, I., Watson, P., Langbein, W. and Borri, P. 2018. Bessel-beam hyperspectral CARS microscopy with sparse sampling: enabling high-content high-throughput label-free quantitative chemical imaging. Analytical Chemistry 90(6), pp. 3775-3785. (10.1021/acs.analchem.7b04039)
• Sayers, E. J. et al. 2018. Switching of macromolecular ligand display by thermoresponsive polymers mediates endocytosis of multi-conjugate nanoparticles. Bioconjugate Chemistry 29(4), pp. 1030-1046. (10.1021/acs.bioconjchem.7b00704)
• Zaki, A. et al. 2018. Defined covalent assembly of protein molecules on graphene using a genetically encoded photochemical reaction handle. RSC Advances 8, pp. 5768-5775. (10.1039/c7ra11166e)

2017

• Roberts-Dalton, H. D. et al. 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9(36), pp. 13693-13706. (10.1039/C7NR04128D)
• Brazzale, C. et al. 2017. Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells. Nanoscale 9(31), pp. 11137-11147. (10.1039/C7NR02595E)
• Perry, I. et al. 2017. Production of 3D printed scale models from microscope volume datasets for use in STEM education. EMS Engineering Science Journal 1(1), article number: 2.

2016

• Di Napoli, C., Pope, I., Masia, F., Langbein, W., Watson, P. and Borri, P. 2016. Quantitative spatiotemporal chemical profiling of individual lipid droplets by hyperspectral CARS microscopy in living human adipose-derived stem cells. Analytical Chemistry 88(7), pp. 3677-3685. (10.1021/acs.analchem.5b04468)

2015

• Moody, P. R., Sayers, E. J., Magnusson, J. P., Alexander, C., Borri, P., Watson, P. and Jones, A. T. 2015. Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy 23(12), pp. 1888-1898. (10.1038/mt.2015.178)
• Reddington, S. C., Driezis, S., Hartley, A. M., Watson, P. D., Rizkallah, P. J. and Jones, D. D. 2015. Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein. RSC Advances 5(95), pp. 77734-77738. (10.1039/C5RA13552D)
• He, L., Watson, P. D. and Jones, A. T. 2015. Visualizing actin architectures in cells incubated with cell-penetrating peptides. In: Langel, U. ed. Cell-Penetrating Peptides: Methods and Protocols., Vol. 1324. Methods in Molecular Biology Vol. 1324. Springer, pp. 247-259., (10.1007/978-1-4939-2806-4_16)

2014

• Sayers, E. J., Cleal, K., Eissa, N. G., Watson, P. D. and Jones, A. T. 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195, pp. 55-62. (10.1016/j.jconrel.2014.07.055)
• Pope, I. et al. 2014. Coherent anti-Stokes Raman scattering microscopy of single nanodiamonds. Nature Nanotechnology 9(11), pp. 940-946. (10.1038/nnano.2014.210)
• Di Napoli, C., Pope, I., Masia, F., Watson, P. D., Langbein, W. W. and Borri, P. 2014. Hyperspectral and differential CARS microscopy for quantitative chemical imaging in human adipocytes. Biomedical Optics Express 5(5), pp. 1378-1390. (10.1364/BOE.5.001378)

2013

• Reddington, S. C., Rizkallah, P., Watson, P. D., Pearson, R., Tippmann, E. M. and Jones, D. D. 2013. Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence. Angewandte Chemie - International Edition 52(23), pp. 5974-5977. (10.1002/anie.201301490)
• Pope, I., Langbein, W. W., Watson, P. D. and Borri, P. 2013. Simultaneous hyperspectral differential-CARS, TPF and SHG microscopy with a single 5 fs Ti:Sa laser. Optics Express 21(6), pp. 7096-7106. (10.1364/OE.21.007096)
• Reddington, S. C., Watson, P. D., Rizkallah, P., Tippmann, E. M. and Jones, D. D. 2013. Genetically encoding phenyl azide chemistry: new uses and ideas for classical biochemistry. Biochemical Society Transactions 41(5), pp. 1177-1182. (10.1042/BST20130094)
• Cleal, K., He, L., Watson, P. D. and Jones, A. T. 2013. Endocytosis, intracellular traffic and fate of cell penetrating peptide based conjugates and nanoparticles. Current Pharmaceutical Design 19(16), pp. 2878-2894. (10.2174/13816128113199990297)

2012

• Pope, I., Langbein, W. W., Borri, P. and Watson, P. D. 2012. Live cell imaging with chemical specificity using dual frequency CARS microscopy. In: Conn, P. M. ed. Imaging and Spectroscopic Analysis of Living Cells — Optical and Spectroscopic Techniques. Methods in Enzymology Vol. 504. Amsterdam: Elsevier, pp. 273-291., (10.1016/B978-0-12-391857-4.00014-8)

2011

• Langbein, W. W., Rocha-Mendoza, I., Masia, F., Di Napoli, C., Pope, I., Watson, P. D. and Borri, P. 2011. Differential CARS microscopy with linearly chirped femtosecond laser pulses. Presented at: Multiphoton Microscopy in the Biomedical Sciences XI, San Francisco, CA, USA, 23-25 January 2011 Presented at Periasamy, A., König, K. and So, P. T. C. eds.Multiphoton Microscopy in the Biomedical Sciences XI, Vol. 7903. SPIE Proceedings SPIE pp. 79031I., (10.1117/12.873872)
• Masia, F., Langbein, W. W., Watson, P. D. and Borri, P. 2011. Triply surface-plasmon resonant four-wave mixing imaging of gold nanoparticles. Presented at: Plasmonics in Biology and Medicine VIII, San Francisco, CA, USA, 23-24 January 2011 Presented at Vo-Dinh, T. and Lakowicz, J. R. eds.Plasmonics in Biology and Medicine VIII, Vol. 7911. Proceedings of SPIE S P I E - International Society for Optical Engineering pp. 79110Y., (10.1117/12.873883)
• Pope, I., Langbein, W. W., Borri, P. and Watson, P. D. 2011. CARS imaging for high throughput microscopy. Biotech International 23(Apr/Ma), pp. 11-13.

2010

• Masia, F., Langbein, W. W., Borri, P. and Watson, P. D. 2010. Four-wave mixing imaging to study protein entry and release in mammalian cells [Abstract]. Drug Discovery Today 15(23-24), pp. 1089. (10.1016/j.drudis.2010.09.377)
• Spooner, R. A. and Watson, P. D. 2010. Drug targeting: Learning from toxin entry and trafficking in mammalian cells. Current Opinion in Drug Discovery & Development 13(1), pp. 86-95.

2009

• Hughes, H. et al. 2009. Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER. Journal of Cell Science 122(16), pp. 2924-2934. (10.1242/jcs.044032)
• Langbein, W. W., Watson, P. D. and Borri, P. 2009. Four-wave mixing of gold nanoparticles for three-dimensional cell microscopy. Presented at: Lasers and Electro-Optics 2009 and the European Quantum Electronics Conference. CLEO Europe - EQEC 2009. European Conference on, Munich, Germany, 14-19 June 2009 Presented at Masia, F. et al. eds.2009 Conference on Lasers & Electro-Optics Europe & 11th European Quantum Electronics Conference (CLEO EUROPE/EQEC 2009). Institute of Electrical and Electronics Engineers ( IEEE ), (10.1109/CLEOE-EQEC.2009.5191714)
• Masia, F., Langbein, W. W., Watson, P. D. and Borri, P. 2009. Resonant four-wave mixing of gold nanoparticles for three-dimensional cell microscopy. Optics Letters 34(12), pp. 1816-1818. (10.1364/OL.34.001816)
• Watson, P. D. 2009. Live cell imaging for target and drug discovery. Drug News and Perspectives 22(2), pp. 69-79.
• Shimshoni, J. A., Dalton, E. C., Watson, P. D., Yagen, B., Bialer, M. and Harwood, A. J. 2009. Evaluation of the effects of propylisopropylacetic acid (PIA) on neuronal growth cone morphology. Neuropharmacology 56(4), pp. 831-837. (10.1016/j.neuropharm.2009.01.014)
• Rocha-Mendoza, I., Langbein, W. W., Watson, P. D. and Borri, P. 2009. Differential coherent anti-Stokes Raman scattering microscopy with linearly chirped femtosecond laser pulses. Optics Letters 34(15), pp. 2258-2260. (10.1364/OL.34.002258)

2008

• Wakana, Y. et al. 2008. Bap31 Is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated degradation. Molecular Biology of the Cell 19(5), pp. 1825-1836. (10.1091/mbc.E07-08-0781)
• Spooner, R. A. et al. 2008. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochemical Journal 414(3), pp. 471-484. (10.1042/BJ20080149)
• Wakana, Y. et al. 2008. Bap31 is an itinerant protein that moves between the peripheral ER and a juxtanuclear compartment related to ER-associated degradation. Molecular Biology of the Cell 19(5), pp. 1825-1836. (10.1091/mbc.E07-08-0781)

2006

• Watson, P. D. and Stephens, D. J. 2006. Microtubule plus-end loading of p150Glued is mediated by EB1 and Clip-170 but is not required for intracellular membrane traffic in mammalian cells. Journal Cell Science 119(Pt 13), pp. 2758-67. (10.1242/jcs.02999)
• Watson, P. D., Townley, A. K., Koka, P., Palmer, K. J. and Stephens, D. J. 2006. Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells. Traffic 7(12), pp. 1678-1687. (10.1111/j.1600-0854.2006.00493.x)

2005

• Watson, P. D., Jones, A. T. and Stephens, D. J. 2005. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Advanced Drug Delivery Reviews 57(1), pp. 43-61. (10.1016/j.addr.2004.05.003)

2004

• Watson, P. D., Forster, R., Palmer, K. J., Pepperkok, R. and Stephens, D. J. 2004. Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nature Cell Biology 7, pp. 48-55. (10.1038/ncb1206)
• Spooner, R. A. et al. 2004. Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum. Biochemical Journal 383(Pt 2), pp. 285-293. (10.1042/BJ20040742)

2003

• Lord, J. M. et al. 2003. Retrograde transport of toxins across the endoplasmic reticulum membrane. Biochemical Society Transactions 31, pp. 1260-1262.