![Lawrence Wilkinson](https://profiles-cardiff.imgix.net/attachments/3679?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Lawrence Wilkinson
Teams and roles for Lawrence Wilkinson
Co Director, Neuroscience and Mental Health Innovation Institute
Overview
Lawrence Wilkinson is Professor of Behavioural Genetics, a position he holds jointly in Cardiff University's Schools ofMedicine and Psychology.
Professor Wilkinson's research activities are focused on how genetic and epigenetic mechanisms influence the way the brain functions. He works closely with colleagues within the Behavioural Genetics Group (BGG) and the Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics in Cardiff and with academic and industrial colleagues nationally and internationally.
Professor Wilkinson and his colleagues in the BGG bring to the Research Institute particular expertise in pre-clinical genetic models, with a strong emphasis on moving findings from pre-clinical models into a better understanding of mental and neurological illness in people.
Working alongside colleagues from the School of Psychology and the MRC Centre for Neuropsychiatric Genetics and Genomics, Professor Wilkinson's current research focuses on: epigenetic effects on brain and behaviour; sex chromosome effects on behaviour and risk for mental disorder; the functional relevance of risk genes for schizophrenia and; familial forms of dementia.
Publication
2025
- Gasalla, P. et al. 2025. Reduced cacna1c expression produces anhedonic reactions to palatable sucrose in rats: No interactions with juvenile or adult stress. Genes, Brain and Behavior 24 (2) e70021. (10.1111/gbb.70021)
- Moon, A. et al. 2025. Reduced gene dosage of the psychiatric risk gene Cacna1c is associated with impairments in hypothalamic–pituitary–adrenal axis activity in rats. International Journal of Molecular Sciences 26 (12) 5547. (10.3390/ijms26125547)
- Smart, S. E. et al. 2025. The role of SLC39A8.p.( Ala391Thr ) in schizophrenia symptom severity and cognitive ability: cross‐sectional studies of schizophrenia and the general UK population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 198 (7), pp.135-146. (10.1002/ajmg.b.33037)
2024
- Bosworth, M. L. et al. 2024. Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. PLoS ONE (10.1371/journal.pone.0298717)
- Correa-da-Silva, F. et al., 2024. Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion. Acta Neuropathologica 147 64. (10.1007/s00401-024-02714-0)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14 (1) 256. (10.1038/s41398-024-02969-x)
2023
- Griesius, S. et al., 2023. A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 22 (6) e12865. (10.1111/gbb.12865)
2022
- Clifton, N. et al. 2022. Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics 31 (18), pp.3095-3106. (10.1093/hmg/ddac105)
- Griesius, S. et al., 2022. Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity. Neuropsychopharmacology 47 , pp.1367-1378. (10.1038/s41386-022-01277-6)
- Pass, R. et al. 2022. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior 21 (4) e12799. (10.1111/gbb.12799)
- Silva, A. I. et al. 2022. Neuroimaging findings in neurodevelopmental copy number variants: identifying molecular pathways to convergent phenotypes. Biological Psychiatry 92 (5), pp.341-361. (10.1016/j.biopsych.2022.03.018)
- Waldron, S. et al. 2022. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 21 (4) e12797. (10.1111/gbb.12797)
- Westacott, L. and Wilkinson, L. 2022. Complement dependent synaptic reorganisation during critical periods of brain development and risk for psychiatric disorder. Frontiers in Neuroscience 16 840266. (10.3389/fnins.2022.840266)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99 , pp.70-82. (10.1016/j.bbi.2021.09.005)
2021
- Haan, N. et al. 2021. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational Psychiatry 11 (1) 313. (10.1038/s41398-021-01415-6)
- Silva, A. I. et al. 2021. Analysis of diffusion tensor imaging data from the UK Biobank confirms dosage effect of 15q11.2 copy number variation on white matter and shows association with cognition. Biological Psychiatry 90 (5), pp.307-316. (10.1016/j.biopsych.2021.02.969)
- Tigaret, C. M. et al. 2021. Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c. Molecular Psychiatry 26 , pp.1748-1760. (10.1038/s41380-020-01001-0)
- Westacott, L. J. et al. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98 , pp.136-150. (10.1016/j.bbi.2021.08.215)
2020
- Clifton, N. E. et al. 2020. FMRP and CYFIP1 at the synapse and their role in psychiatric vulnerability. Complex Psychiatry (10.1159/000506858)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237 , pp.1745-1756. (10.1007/s00213-020-05496-x)
- Moon, A. L. et al. 2020. Cacna1c hemizygosity results in aberrant fear conditioning to neutral stimuli. Schizophrenia Bulletin 46 (5), pp.1231-1238. (10.1093/schbul/sbz127)
2019
- Chapman, R. M. et al., 2019. Convergent evidence that ZNF804A is a regulator of pre-messenger RNA processing and gene expression. Schizophrenia Bulletin 45 (6), pp.1267-1278. (10.1093/schbul/sby183)
- Davies, J. R. et al. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28 (18), pp.3013-3023. (10.1093/hmg/ddz100)
- Davies, W. and Wilkinson, L. 2019. Editorial overview: special issue on epigenetics and genomic imprinting. Current Opinion in Behavioral Sciences 25 , pp.iii-v. (10.1016/j.cobeha.2018.12.006)
- Humby, T. et al. 2019. Feeding behaviour, risk-sensitivity and response control: effects of 5-HT 2C receptor manipulations. Philosophical Transactions B: Biological Sciences 374 (1766) 20180144. (10.1098/rstb.2018.0144)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
- Silva, A. I. et al. 2019. Reciprocal white matter changes associated with copy number variation at 15q11.2 BP1-BP2: A diffusion tensor imaging study. Biological Psychiatry 85 (7), pp.563-572. (10.1016/j.biopsych.2018.11.004)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
2018
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209 (1), pp.233-239. (10.1534/genetics.118.300898)
- Iliescu, A. F. et al. 2018. The nature of phenotypic variation in Pavlovian conditioning. Journal of Experimental Psychology: Animal Learning and Cognition 44 (4), pp.358-369. (10.1037/xan0000177)
- Moon, A. L. et al. 2018. CACNA1C: Association with pychiatric disorders, behavior, and neurogenesis. Schizophrenia Bulletin 44 (5), pp.958-965. (10.1093/schbul/sby096)
2017
- Clifton, N. E. et al. 2017. Schizophrenia copy number variants and associative learning. Molecular Psychiatry 22 (2), pp.178-182. (10.1038/mp.2016.227)
- Liu, Y. , Wilkinson, L. S. and Robbins, T. W. 2017. ‘Waiting impulsivity’ in isolation-reared and socially-reared rats: effects of amphetamine. Psychopharmacology 234 (9-10), pp.1587-1601. (10.1007/s00213-017-4579-8)
2016
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15 (8), pp.693-701. (10.1111/gbb.12316)
- Garfield, A. S. et al., 2016. Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Molecular Brain 9 95. (10.1186/s13041-016-0277-4)
- Scholz, B. et al., 2016. The regulation of cytokine networks in hippocampal CA1 differentiates extinction from those required for the maintenance of contextual fear memory after recall. PLoS ONE 11 (5) e0153102. (10.1371/journal.pone.0153102)
2015
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4), pp.2105-2113. (10.1111/ejn.12972)
- Heckenast, J. R. , Wilkinson, L. S. and Jones, M. W. 2015. Decoding advances in psychiatric genetics: a focus on neural circuits in rodent models. Advances in Genetics 92 , pp.75-106. (10.1016/bs.adgen.2015.09.001)
- Hinton, R. et al., 2015. Preliminary evidence for aortopathy and an x-linked parent-of-origin effect on aortic valve malformation in a mouse model of Turner syndrome. Journal of Cardiovascular Development and Disease 2 (3), pp.190-199. (10.3390/jcdd2030190)
2014
- Davies, W. et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39 , pp.2622-2632. (10.1038/npp.2014.115)
2013
- Humby, T. et al. 2013. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology 38 (11), pp.2150-2159. (10.1038/npp.2013.112)
- Kopsida, E. et al., 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8 (8) e73699. (10.1371/journal.pone.0073699)
- Mikaelsson, M. A. et al. 2013. Placental programming of anxiety in adulthood revealed by lgf2-null models. Nature Communications 4 2311. (10.1038/ncomms3311)
- Reichelt, A. C. et al. 2013. Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory 104 , pp.73-81. (10.1016/j.nlm.2013.05.005)
- Schmechtig, A. et al., 2013. The effects of ketamine and risperidone on eye movement control in healthy volunteers. Translational Psychiatry 3 (12) e334. (10.1038/tp.2013.109)
- Schmechtig, A. et al., 2013. Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy. Psychopharmacology 227 (2), pp.331-345. (10.1007/s00213-013-2973-4)
2012
- Koychev, I. et al., 2012. A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: A three-center double-blind placebo-controlled study. European Neuropsychopharmacology 22 (7), pp.469-481. (10.1016/j.euroneuro.2011.10.005)
- Relkovic, D. et al. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126 (3), pp.488-492. (10.1037/a0028155)
2011
- Garfield, A. S. et al. 2011. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 469 (7331), pp.534-538. (10.1038/nature09651)
- Humby, T. and Wilkinson, L. S. 2011. Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology 11 (5), pp.534-539. (10.1016/j.coph.2011.06.006)
- Koychev, I. et al., 2011. Evaluation of state and trait biomarkers in healthy volunteers for the development of novel drug treatments in schizophrenia. Journal of Psychopharmacology 25 (9), pp.1207-1225. (10.1177/0269881111414450)
- Stergiakouli, E. et al., 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10 (3), pp.334-344. (10.1111/j.1601-183x.2010.00672.x)
2010
- Burne, T. H. .. et al., 2010. Effects of anesthetic agents on socially transmitted olfactory memories in mice. Neurobiology of Learning and Memory 93 (2), pp.268-274. (10.1016/j.nlm.2009.10.007)
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31 (1), pp.156-164. (10.1111/j.1460-9568.2009.07048.x)
- Wilkinson, L. S. 2010. Which parental gene gets the upper hand?. Science 329 (5992), pp.636-637. (10.1126/science.1194692)
2009
- Davies, W. et al. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66 (4), pp.360-367. (10.1016/j.biopsych.2009.01.001)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18 (12), pp.2140-2148. (10.1093/hmg/ddp137)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19 (6), pp.312-319. (10.1097/YPG.0b013e3283328df4)
- Kopsida, E. et al. 2009. The role of the Y chromosome in brain function. The Open Neuroendocrinology Journal 2 (1), pp.20-30. (10.2174/1876528900902010020)
2008
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
- Davies, W. et al. 2008. Imprinted genes and neuroendocrine function. Frontiers in Neuroendocrinology 29 (3), pp.413-427. (10.1016/j.yfrne.2007.12.001)
- Doe, C. et al., 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22 (s2), pp.125. (10.1111/j.1472-8206.2008.00601.x)
- Donald, S. et al., 2008. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America 105 (11), pp.4483-4488. (10.1073/pnas.0712324105)
- Isles, A. R. and Wilkinson, L. S. 2008. Epigenetics: what is it and why is it important to mental disease?. British Medical Bulletin 85 (1), pp.35-45. (10.1093/bmb/ldn004)
2007
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Lambourne, S. L. et al., 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16 (14), pp.1708-1719. (10.1093/hmg/ddm119)
- Wilkinson, L. S. , Davies, W. and Isles, A. R. 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11), pp.832-843. (10.1038/nrn2235)
2006
- Davies, W. et al. 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1), pp.35-44. (10.1002/bies.20341)
- Davies, W. and Wilkinson, L. S. 2006. It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Research 1126 (1), pp.36-45. (10.1016/j.brainres.2006.09.105)
- Humby, T. and Wilkinson, L. S. 2006. If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. S. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Contemporary Clinical Neuroscience Totowa, NJ: Humana Press. , pp.69-83. (10.1007/978-1-59745-058-4_4)
- Isles, A. R. , Davies, W. and Wilkinson, L. S. 2006. Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1476), pp.2229-2237. (10.1098/rstb.2006.1942)
- Talpos, J. C. , Wilkinson, L. S. and Robbins, T. W. 2006. A comparison of multiple 5-HT receptors in two tasks measuring impulsivity. Journal of Psychopharmacology 20 (1), pp.47-58. (10.1177/0269881105056639)
- Tofaris, G. K. et al., 2006. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience 26 (15), pp.3942-3950. (10.1523/JNEUROSCI.4965-05.2006)
2005
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2005. Imprinted gene expression in the brain. Neuroscience & Biobehavioral Reviews 29 (3), pp.421-430. (10.1016/j.neubiorev.2004.11.007)
- Humby, T. , Wilkinson, L. S. and Dawson, G. 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. In: Current Protocols in Neuroscience. Chichester: Wiley(10.1002/0471142301.ns0805hs31)
- Isles, A. R. et al. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22 (4), pp.997-1000. (10.1111/j.1460-9568.2005.04265.x)
- Lambourne, S. L. et al., 2005. Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Molecular and Cellular Biology 25 (1), pp.278-293. (10.1128/MCB.25.1.278-293.2005)
- Plagge, A. et al., 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25 (8), pp.3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
2004
- Davies, W. et al. 2004. Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain. Gene Expression Patterns 4 (6), pp.741-747. (10.1016/j.modgep.2004.03.008)
- Isles, A. R. et al. 2004. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Human Molecular Genetics 13 (17), pp.1849-1855. (10.1093/hmg/ddh203)
- Isles, A. R. et al. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24 (30), pp.6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
- Liu, Y. P. , Wilkinson, L. S. and Robbins, T. W. 2004. Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology 173 (1-2), pp.175-185. (10.1007/s00213-003-1726-1)
2003
- Allen, J. P. et al., 2003. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum. European Journal of Neuroscience 17 (9), pp.1881-1895. (10.1046/j.1460-9568.2003.02629.x)
- Davies, W. et al., 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17 (S), pp.A70.
- Isles, A. R. , Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170 (4), pp.376-382. (10.1007/s00213-003-1551-6)
2002
- Isles, A. R. and Wilkinson, L. S. 2002. Genomic imprinting, hormones and behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426.
- Isles, A. R. and Wilkinson, L. S. 2002. Neuroendocrinology Briefings 16: Genomic Imprinting, Hormones and Behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426. (10.1046/j.1365-2826.2002.00445.x)
2001
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2001. Imprinted genes and mental dysfunction. Annals of Medicine 33 (6), pp.428-436. (10.3109/07853890108995956)
- Mooslehner, K. A. et al., 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21 (16), pp.5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
- Ward, B. O. , Billinton, A. and Wilkinson, L. S. 2001. Learning, remembering and applying an arbitrary non-matching to position rule in mice. Behavioural Brain Research 125 (1-2), pp.229-236. (10.1016/S0166-4328(01)00304-7)
2000
- Collins, P. et al., 2000. The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function. Behavioral Neuroscience 114 (1), pp.3-17. (10.1037/0735-7044.114.1.3)
- Isles, A. R. and Wilkinson, L. S. 2000. Imprinted genes, cognition and behaviour. Trends in Cognitive Sciences 4 (8), pp.309-318. (10.1016/S1364-6613(00)01504-7)
1999
- Hall, F. S. et al., 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32 (1), pp.37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)
- Humby, T. et al. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11 (8), pp.2813-2823. (10.1046/j.1460-9568.1999.00701.x)
- Ward, B. et al., 1999. Forebrain serotonin depletion facilitates the acquisition and performance of a conditional visual discrimination task in rats. Behavioural Brain Research 100 (1-2), pp.51-65. (10.1016/S0166-4328(98)00112-0)
1998
- Hall, F. S. et al., 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59 (4), pp.859-872. (10.1016/S0091-3057(97)00510-8)
- Wilkinson, L. S. et al. 1998. Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience 10 (3), pp.1019-1026. (10.1046/j.1460-9568.1998.00119.x)
1997
- Hall, F. S. et al., 1997. The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior 62 (2), pp.281-290. (10.1016/S0031-9384(97)00115-7)
- Hall, F. S. et al., 1997. The effects of isolation-rearing on preference by rats for a novel environment. Physiology & Behavior 62 (2), pp.299-303. (10.1016/S0031-9384(97)00117-0)
- Hall, F. S. et al., 1997. The effects of isolation-rearing on sucrose consumption in rats. Physiology & Behavior 62 (2), pp.291-297. (10.1016/S0031-9384(97)00116-9)
- Wilkinson, L. S. 1997. The nature of interactions involving prefrontal and striatal dopamine systems. Journal of Psychopharmacology 11 (2), pp.143-150. (10.1177/026988119701100207)
- Wilkinson, L. S. et al. 1997. Contrasting effects of excitotoxic lesions of the prefrontal cortex on the behavioural response to d-amphetamine and presynaptic and postsynaptic measures of striatal dopamine function in monkeys. Neuroscience 80 (3), pp.717-730. (10.1016/S0306-4522(97)00075-4)
1996
- Humby, T. et al., 1996. Prepulses inhibit startle-induced reductions of extracellular dopamine in the nucleus accumbens of rat. Journal of Neuroscience 16 (6), pp.2149-2156.
- Matthews, K. et al., 1996. Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: Effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine. Psychopharmacology 126 (1), pp.75-84.
- Matthews, K. , Wilkinson, L. S. and Robbins, T. W. 1996. Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood. Physiology & Behavior 59 (1), pp.99-107. (10.1016/0031-9384(95)02069-1)
- Robbins, T. , Jones, G. and Wilkinson, L. S. 1996. Behavioural and neurochemical effects of early social deprivation in the rat. Journal of Psychopharmacology 10 (1), pp.39-47. (10.1177/026988119601000107)
1995
- Geyer, M. A. et al., 1995. Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]. Biological Psychiatry 37 (9), pp.634. (10.1016/0006-3223(95)94560-J)
- McAlonan, G. M. et al., 1995. The effects of AMPA-induced lesions of the septo-hippocampal cholinergic projection on aversive conditioning to explicit and contextual cues and spatial learning in the water maze. European Journal of Neuroscience 7 (2), pp.281-292. (10.1111/j.1460-9568.1995.tb01064.x)
- Wilkinson, L. S. et al. 1995. Differential Effects of Forebrain 5-Hydroxytryptamine Depletions on Pavlovian Aversive Conditioning to Discrete and Contextual Stimuli in the Rat. European Journal of Neuroscience 7 (10), pp.2042-2052. (10.1111/j.1460-9568.1995.tb00627.x)
1994
- Marston, H. M. et al., 1994. Effects of excitotoxic lesions of the septum and vertical limb nucleus of the diagonal band of Broca on conditional visual discrimination: relationship between performance and choline acetyltransferase activity in the cingulate cortex. Journal of Neuroscience 14 (4), pp.2009-2019.
- Phillips, G. D. et al., 1994. Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine. Psychopharmacology 115 (3), pp.407-418.
- Roberts, A. C. et al., 1994. 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine. Journal of Neuroscience 14 (5), pp.2531-2544.
- Torres, E. M. et al., 1994. Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 63 (1), pp.95-122. (10.1016/0306-4522(94)90010-8)
- Wilkinson, L. S. et al. 1994. Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology 10 (1), pp.61-72. (10.1038/npp.1994.8)
1993
- Geyer, M. A. et al., 1993. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biological psychiatry 34 (6), pp.361-372. (10.1016/0006-3223(93)90180-L)
- Wilkinson, L. S. et al. 1993. Enhancement of amphetamine-induced locomotor activity and dopamine release in nucleus accumbens following excitotoxic lesions of the hippocampus. Behavioural Brain Research 55 (2), pp.143-150.
1992
- Calamandrei, G. , Wilkinson, L. S. and Keverne, E. B. 1992. Olfactory recognition of infants in laboratory mice: Role of noradrenergic mechanisms. Physiology & Behavior 52 (5), pp.901-907. (10.1016/0031-9384(92)90369-D)
1991
- Page, K. J. et al., 1991. Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: Differential dependence on cholinergic neuronal loss. Neuroscience 43 (2-3), pp.457-472. (10.1016/0306-4522(91)90308-B)
1990
- Wilkinson, L. S. and Collard, K. J. 1990. Synaptosomal tryptophan uptake and efflux following lesion of central 5-hydroxytryptaminergic neurones. British Journal of Pharmacology 101 (4), pp.981-985. (10.1111/j.1476-5381.1990.tb14192.x)
1989
- Foster, G. A. et al., 1989. Structural and functional analysis of raphe neurone implants into denervated rat spinal cord. Brain Research Bulletin 22 (1), pp.131-137. (10.1016/0361-9230(89)90137-8)
1988
- Collard, K. , Wilkinson, L. S. and Lewis, D. 1988. Studies on the mechanism by which tryptophan efflux from isolated synaptosomes is stimulated by depolarization. British Journal of Pharmacology 93 (2), pp.341-348. (10.1111/j.1476-5381.1988.tb11440.x)
- Davies, M. , Wilkinson, L. S. and Roberts, M. H. 1988. Evidence for depressant 5-HT1-like receptors on rat brainstem neurones. British Journal of Pharmacology 94 (2), pp.492-499. (10.1111/j.1476-5381.1988.tb11552.x)
- Davies, M. , Wilkinson, L. S. and Roberts, M. H. 1988. Evidence for excitatory 5-HT2-receptors on rat brainstem neurones. British Journal of Pharmacology 94 (2), pp.483-491. (10.1111/j.1476-5381.1988.tb11551.x)
1984
- Wilkinson, L. S. and Collard, K. J. 1984. Opposite effects of extracellular sodium removal on the uptake of tryptophan into rat cortical slices and synaptosomes. Journal of Neuroscience 43 (1), pp.274-275. (10.1111/j.1471-4159.1984.tb06708.x)
1982
- Collard, K. J. et al., 1982. The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes. Journal of Neural Transmission 53 (2-3), pp.223-230. (10.1007/BF01243414)
Articles
- Allen, J. P. et al., 2003. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum. European Journal of Neuroscience 17 (9), pp.1881-1895. (10.1046/j.1460-9568.2003.02629.x)
- Bosworth, M. L. et al. 2024. Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. PLoS ONE (10.1371/journal.pone.0298717)
- Burne, T. H. .. et al., 2010. Effects of anesthetic agents on socially transmitted olfactory memories in mice. Neurobiology of Learning and Memory 93 (2), pp.268-274. (10.1016/j.nlm.2009.10.007)
- Calamandrei, G. , Wilkinson, L. S. and Keverne, E. B. 1992. Olfactory recognition of infants in laboratory mice: Role of noradrenergic mechanisms. Physiology & Behavior 52 (5), pp.901-907. (10.1016/0031-9384(92)90369-D)
- Chapman, R. M. et al., 2019. Convergent evidence that ZNF804A is a regulator of pre-messenger RNA processing and gene expression. Schizophrenia Bulletin 45 (6), pp.1267-1278. (10.1093/schbul/sby183)
- Clifton, N. E. et al. 2017. Schizophrenia copy number variants and associative learning. Molecular Psychiatry 22 (2), pp.178-182. (10.1038/mp.2016.227)
- Clifton, N. et al. 2022. Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics 31 (18), pp.3095-3106. (10.1093/hmg/ddac105)
- Clifton, N. E. et al. 2020. FMRP and CYFIP1 at the synapse and their role in psychiatric vulnerability. Complex Psychiatry (10.1159/000506858)
- Collard, K. J. et al., 1982. The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes. Journal of Neural Transmission 53 (2-3), pp.223-230. (10.1007/BF01243414)
- Collard, K. , Wilkinson, L. S. and Lewis, D. 1988. Studies on the mechanism by which tryptophan efflux from isolated synaptosomes is stimulated by depolarization. British Journal of Pharmacology 93 (2), pp.341-348. (10.1111/j.1476-5381.1988.tb11440.x)
- Collins, P. et al., 2000. The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function. Behavioral Neuroscience 114 (1), pp.3-17. (10.1037/0735-7044.114.1.3)
- Correa-da-Silva, F. et al., 2024. Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion. Acta Neuropathologica 147 64. (10.1007/s00401-024-02714-0)
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4), pp.2105-2113. (10.1111/ejn.12972)
- Davies, J. R. et al. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28 (18), pp.3013-3023. (10.1093/hmg/ddz100)
- Davies, M. , Wilkinson, L. S. and Roberts, M. H. 1988. Evidence for depressant 5-HT1-like receptors on rat brainstem neurones. British Journal of Pharmacology 94 (2), pp.492-499. (10.1111/j.1476-5381.1988.tb11552.x)
- Davies, M. , Wilkinson, L. S. and Roberts, M. H. 1988. Evidence for excitatory 5-HT2-receptors on rat brainstem neurones. British Journal of Pharmacology 94 (2), pp.483-491. (10.1111/j.1476-5381.1988.tb11551.x)
- Davies, W. et al., 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17 (S), pp.A70.
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66 (4), pp.360-367. (10.1016/j.biopsych.2009.01.001)
- Davies, W. et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39 , pp.2622-2632. (10.1038/npp.2014.115)
- Davies, W. et al. 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1), pp.35-44. (10.1002/bies.20341)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2005. Imprinted gene expression in the brain. Neuroscience & Biobehavioral Reviews 29 (3), pp.421-430. (10.1016/j.neubiorev.2004.11.007)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2001. Imprinted genes and mental dysfunction. Annals of Medicine 33 (6), pp.428-436. (10.3109/07853890108995956)
- Davies, W. et al. 2008. Imprinted genes and neuroendocrine function. Frontiers in Neuroendocrinology 29 (3), pp.413-427. (10.1016/j.yfrne.2007.12.001)
- Davies, W. et al. 2004. Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain. Gene Expression Patterns 4 (6), pp.741-747. (10.1016/j.modgep.2004.03.008)
- Davies, W. and Wilkinson, L. 2019. Editorial overview: special issue on epigenetics and genomic imprinting. Current Opinion in Behavioral Sciences 25 , pp.iii-v. (10.1016/j.cobeha.2018.12.006)
- Davies, W. and Wilkinson, L. S. 2006. It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Research 1126 (1), pp.36-45. (10.1016/j.brainres.2006.09.105)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15 (8), pp.693-701. (10.1111/gbb.12316)
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209 (1), pp.233-239. (10.1534/genetics.118.300898)
- Doe, C. et al., 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22 (s2), pp.125. (10.1111/j.1472-8206.2008.00601.x)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18 (12), pp.2140-2148. (10.1093/hmg/ddp137)
- Donald, S. et al., 2008. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America 105 (11), pp.4483-4488. (10.1073/pnas.0712324105)
- Foster, G. A. et al., 1989. Structural and functional analysis of raphe neurone implants into denervated rat spinal cord. Brain Research Bulletin 22 (1), pp.131-137. (10.1016/0361-9230(89)90137-8)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19 (6), pp.312-319. (10.1097/YPG.0b013e3283328df4)
- Garfield, A. S. et al. 2011. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 469 (7331), pp.534-538. (10.1038/nature09651)
- Garfield, A. S. et al., 2016. Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Molecular Brain 9 95. (10.1186/s13041-016-0277-4)
- Gasalla, P. et al. 2025. Reduced cacna1c expression produces anhedonic reactions to palatable sucrose in rats: No interactions with juvenile or adult stress. Genes, Brain and Behavior 24 (2) e70021. (10.1111/gbb.70021)
- Geyer, M. A. et al., 1995. Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]. Biological Psychiatry 37 (9), pp.634. (10.1016/0006-3223(95)94560-J)
- Geyer, M. A. et al., 1993. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biological psychiatry 34 (6), pp.361-372. (10.1016/0006-3223(93)90180-L)
- Griesius, S. et al., 2022. Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity. Neuropsychopharmacology 47 , pp.1367-1378. (10.1038/s41386-022-01277-6)
- Griesius, S. et al., 2023. A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 22 (6) e12865. (10.1111/gbb.12865)
- Haan, N. et al. 2021. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational Psychiatry 11 (1) 313. (10.1038/s41398-021-01415-6)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14 (1) 256. (10.1038/s41398-024-02969-x)
- Hall, F. S. et al., 1997. The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior 62 (2), pp.281-290. (10.1016/S0031-9384(97)00115-7)
- Hall, F. S. et al., 1997. The effects of isolation-rearing on preference by rats for a novel environment. Physiology & Behavior 62 (2), pp.299-303. (10.1016/S0031-9384(97)00117-0)
- Hall, F. S. et al., 1997. The effects of isolation-rearing on sucrose consumption in rats. Physiology & Behavior 62 (2), pp.291-297. (10.1016/S0031-9384(97)00116-9)
- Hall, F. S. et al., 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59 (4), pp.859-872. (10.1016/S0091-3057(97)00510-8)
- Hall, F. S. et al., 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32 (1), pp.37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)
- Heckenast, J. R. , Wilkinson, L. S. and Jones, M. W. 2015. Decoding advances in psychiatric genetics: a focus on neural circuits in rodent models. Advances in Genetics 92 , pp.75-106. (10.1016/bs.adgen.2015.09.001)
- Hinton, R. et al., 2015. Preliminary evidence for aortopathy and an x-linked parent-of-origin effect on aortic valve malformation in a mouse model of Turner syndrome. Journal of Cardiovascular Development and Disease 2 (3), pp.190-199. (10.3390/jcdd2030190)
- Humby, T. et al., 1996. Prepulses inhibit startle-induced reductions of extracellular dopamine in the nucleus accumbens of rat. Journal of Neuroscience 16 (6), pp.2149-2156.
- Humby, T. et al. 2013. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology 38 (11), pp.2150-2159. (10.1038/npp.2013.112)
- Humby, T. et al. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11 (8), pp.2813-2823. (10.1046/j.1460-9568.1999.00701.x)
- Humby, T. et al. 2019. Feeding behaviour, risk-sensitivity and response control: effects of 5-HT 2C receptor manipulations. Philosophical Transactions B: Biological Sciences 374 (1766) 20180144. (10.1098/rstb.2018.0144)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237 , pp.1745-1756. (10.1007/s00213-020-05496-x)
- Humby, T. and Wilkinson, L. S. 2011. Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology 11 (5), pp.534-539. (10.1016/j.coph.2011.06.006)
- Iliescu, A. F. et al. 2018. The nature of phenotypic variation in Pavlovian conditioning. Journal of Experimental Psychology: Animal Learning and Cognition 44 (4), pp.358-369. (10.1037/xan0000177)
- Isles, A. R. et al. 2004. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Human Molecular Genetics 13 (17), pp.1849-1855. (10.1093/hmg/ddh203)
- Isles, A. R. , Davies, W. and Wilkinson, L. S. 2006. Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1476), pp.2229-2237. (10.1098/rstb.2006.1942)
- Isles, A. R. et al. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22 (4), pp.997-1000. (10.1111/j.1460-9568.2005.04265.x)
- Isles, A. R. et al. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24 (30), pp.6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
- Isles, A. R. , Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170 (4), pp.376-382. (10.1007/s00213-003-1551-6)
- Isles, A. R. and Wilkinson, L. S. 2008. Epigenetics: what is it and why is it important to mental disease?. British Medical Bulletin 85 (1), pp.35-45. (10.1093/bmb/ldn004)
- Isles, A. R. and Wilkinson, L. S. 2002. Genomic imprinting, hormones and behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426.
- Isles, A. R. and Wilkinson, L. S. 2000. Imprinted genes, cognition and behaviour. Trends in Cognitive Sciences 4 (8), pp.309-318. (10.1016/S1364-6613(00)01504-7)
- Isles, A. R. and Wilkinson, L. S. 2002. Neuroendocrinology Briefings 16: Genomic Imprinting, Hormones and Behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426. (10.1046/j.1365-2826.2002.00445.x)
- Kopsida, E. et al., 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8 (8) e73699. (10.1371/journal.pone.0073699)
- Kopsida, E. et al. 2009. The role of the Y chromosome in brain function. The Open Neuroendocrinology Journal 2 (1), pp.20-30. (10.2174/1876528900902010020)
- Koychev, I. et al., 2011. Evaluation of state and trait biomarkers in healthy volunteers for the development of novel drug treatments in schizophrenia. Journal of Psychopharmacology 25 (9), pp.1207-1225. (10.1177/0269881111414450)
- Koychev, I. et al., 2012. A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: A three-center double-blind placebo-controlled study. European Neuropsychopharmacology 22 (7), pp.469-481. (10.1016/j.euroneuro.2011.10.005)
- Lambourne, S. L. et al., 2005. Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Molecular and Cellular Biology 25 (1), pp.278-293. (10.1128/MCB.25.1.278-293.2005)
- Lambourne, S. L. et al., 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16 (14), pp.1708-1719. (10.1093/hmg/ddm119)
- Liu, Y. P. , Wilkinson, L. S. and Robbins, T. W. 2004. Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology 173 (1-2), pp.175-185. (10.1007/s00213-003-1726-1)
- Liu, Y. , Wilkinson, L. S. and Robbins, T. W. 2017. ‘Waiting impulsivity’ in isolation-reared and socially-reared rats: effects of amphetamine. Psychopharmacology 234 (9-10), pp.1587-1601. (10.1007/s00213-017-4579-8)
- Marston, H. M. et al., 1994. Effects of excitotoxic lesions of the septum and vertical limb nucleus of the diagonal band of Broca on conditional visual discrimination: relationship between performance and choline acetyltransferase activity in the cingulate cortex. Journal of Neuroscience 14 (4), pp.2009-2019.
- Matthews, K. et al., 1996. Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: Effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine. Psychopharmacology 126 (1), pp.75-84.
- Matthews, K. , Wilkinson, L. S. and Robbins, T. W. 1996. Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood. Physiology & Behavior 59 (1), pp.99-107. (10.1016/0031-9384(95)02069-1)
- McAlonan, G. M. et al., 1995. The effects of AMPA-induced lesions of the septo-hippocampal cholinergic projection on aversive conditioning to explicit and contextual cues and spatial learning in the water maze. European Journal of Neuroscience 7 (2), pp.281-292. (10.1111/j.1460-9568.1995.tb01064.x)
- Mikaelsson, M. A. et al. 2013. Placental programming of anxiety in adulthood revealed by lgf2-null models. Nature Communications 4 2311. (10.1038/ncomms3311)
- Moon, A. et al. 2025. Reduced gene dosage of the psychiatric risk gene Cacna1c is associated with impairments in hypothalamic–pituitary–adrenal axis activity in rats. International Journal of Molecular Sciences 26 (12) 5547. (10.3390/ijms26125547)
- Moon, A. L. et al. 2020. Cacna1c hemizygosity results in aberrant fear conditioning to neutral stimuli. Schizophrenia Bulletin 46 (5), pp.1231-1238. (10.1093/schbul/sbz127)
- Moon, A. L. et al. 2018. CACNA1C: Association with pychiatric disorders, behavior, and neurogenesis. Schizophrenia Bulletin 44 (5), pp.958-965. (10.1093/schbul/sby096)
- Mooslehner, K. A. et al., 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21 (16), pp.5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
- Page, K. J. et al., 1991. Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: Differential dependence on cholinergic neuronal loss. Neuroscience 43 (2-3), pp.457-472. (10.1016/0306-4522(91)90308-B)
- Pass, R. et al. 2022. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior 21 (4) e12799. (10.1111/gbb.12799)
- Phillips, G. D. et al., 1994. Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine. Psychopharmacology 115 (3), pp.407-418.
- Plagge, A. et al., 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25 (8), pp.3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Reichelt, A. C. et al. 2013. Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory 104 , pp.73-81. (10.1016/j.nlm.2013.05.005)
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31 (1), pp.156-164. (10.1111/j.1460-9568.2009.07048.x)
- Relkovic, D. et al. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126 (3), pp.488-492. (10.1037/a0028155)
- Robbins, T. , Jones, G. and Wilkinson, L. S. 1996. Behavioural and neurochemical effects of early social deprivation in the rat. Journal of Psychopharmacology 10 (1), pp.39-47. (10.1177/026988119601000107)
- Roberts, A. C. et al., 1994. 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine. Journal of Neuroscience 14 (5), pp.2531-2544.
- Schmechtig, A. et al., 2013. The effects of ketamine and risperidone on eye movement control in healthy volunteers. Translational Psychiatry 3 (12) e334. (10.1038/tp.2013.109)
- Schmechtig, A. et al., 2013. Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy. Psychopharmacology 227 (2), pp.331-345. (10.1007/s00213-013-2973-4)
- Scholz, B. et al., 2016. The regulation of cytokine networks in hippocampal CA1 differentiates extinction from those required for the maintenance of contextual fear memory after recall. PLoS ONE 11 (5) e0153102. (10.1371/journal.pone.0153102)
- Silva, A. I. et al. 2022. Neuroimaging findings in neurodevelopmental copy number variants: identifying molecular pathways to convergent phenotypes. Biological Psychiatry 92 (5), pp.341-361. (10.1016/j.biopsych.2022.03.018)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
- Silva, A. I. et al. 2021. Analysis of diffusion tensor imaging data from the UK Biobank confirms dosage effect of 15q11.2 copy number variation on white matter and shows association with cognition. Biological Psychiatry 90 (5), pp.307-316. (10.1016/j.biopsych.2021.02.969)
- Silva, A. I. et al. 2019. Reciprocal white matter changes associated with copy number variation at 15q11.2 BP1-BP2: A diffusion tensor imaging study. Biological Psychiatry 85 (7), pp.563-572. (10.1016/j.biopsych.2018.11.004)
- Smart, S. E. et al. 2025. The role of SLC39A8.p.( Ala391Thr ) in schizophrenia symptom severity and cognitive ability: cross‐sectional studies of schizophrenia and the general UK population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 198 (7), pp.135-146. (10.1002/ajmg.b.33037)
- Stergiakouli, E. et al., 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10 (3), pp.334-344. (10.1111/j.1601-183x.2010.00672.x)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Talpos, J. C. , Wilkinson, L. S. and Robbins, T. W. 2006. A comparison of multiple 5-HT receptors in two tasks measuring impulsivity. Journal of Psychopharmacology 20 (1), pp.47-58. (10.1177/0269881105056639)
- Tigaret, C. M. et al. 2021. Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c. Molecular Psychiatry 26 , pp.1748-1760. (10.1038/s41380-020-01001-0)
- Tofaris, G. K. et al., 2006. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience 26 (15), pp.3942-3950. (10.1523/JNEUROSCI.4965-05.2006)
- Torres, E. M. et al., 1994. Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 63 (1), pp.95-122. (10.1016/0306-4522(94)90010-8)
- Waldron, S. et al. 2022. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 21 (4) e12797. (10.1111/gbb.12797)
- Ward, B. O. , Billinton, A. and Wilkinson, L. S. 2001. Learning, remembering and applying an arbitrary non-matching to position rule in mice. Behavioural Brain Research 125 (1-2), pp.229-236. (10.1016/S0166-4328(01)00304-7)
- Ward, B. et al., 1999. Forebrain serotonin depletion facilitates the acquisition and performance of a conditional visual discrimination task in rats. Behavioural Brain Research 100 (1-2), pp.51-65. (10.1016/S0166-4328(98)00112-0)
- Westacott, L. and Wilkinson, L. 2022. Complement dependent synaptic reorganisation during critical periods of brain development and risk for psychiatric disorder. Frontiers in Neuroscience 16 840266. (10.3389/fnins.2022.840266)
- Westacott, L. J. et al. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98 , pp.136-150. (10.1016/j.bbi.2021.08.215)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99 , pp.70-82. (10.1016/j.bbi.2021.09.005)
- Wilkinson, L. S. 1997. The nature of interactions involving prefrontal and striatal dopamine systems. Journal of Psychopharmacology 11 (2), pp.143-150. (10.1177/026988119701100207)
- Wilkinson, L. S. 2010. Which parental gene gets the upper hand?. Science 329 (5992), pp.636-637. (10.1126/science.1194692)
- Wilkinson, L. S. and Collard, K. J. 1984. Opposite effects of extracellular sodium removal on the uptake of tryptophan into rat cortical slices and synaptosomes. Journal of Neuroscience 43 (1), pp.274-275. (10.1111/j.1471-4159.1984.tb06708.x)
- Wilkinson, L. S. and Collard, K. J. 1990. Synaptosomal tryptophan uptake and efflux following lesion of central 5-hydroxytryptaminergic neurones. British Journal of Pharmacology 101 (4), pp.981-985. (10.1111/j.1476-5381.1990.tb14192.x)
- Wilkinson, L. S. , Davies, W. and Isles, A. R. 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11), pp.832-843. (10.1038/nrn2235)
- Wilkinson, L. S. et al. 1997. Contrasting effects of excitotoxic lesions of the prefrontal cortex on the behavioural response to d-amphetamine and presynaptic and postsynaptic measures of striatal dopamine function in monkeys. Neuroscience 80 (3), pp.717-730. (10.1016/S0306-4522(97)00075-4)
- Wilkinson, L. S. et al. 1998. Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience 10 (3), pp.1019-1026. (10.1046/j.1460-9568.1998.00119.x)
- Wilkinson, L. S. et al. 1995. Differential Effects of Forebrain 5-Hydroxytryptamine Depletions on Pavlovian Aversive Conditioning to Discrete and Contextual Stimuli in the Rat. European Journal of Neuroscience 7 (10), pp.2042-2052. (10.1111/j.1460-9568.1995.tb00627.x)
- Wilkinson, L. S. et al. 1994. Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology 10 (1), pp.61-72. (10.1038/npp.1994.8)
- Wilkinson, L. S. et al. 1993. Enhancement of amphetamine-induced locomotor activity and dopamine release in nucleus accumbens following excitotoxic lesions of the hippocampus. Behavioural Brain Research 55 (2), pp.143-150.
Book sections
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
- Humby, T. and Wilkinson, L. S. 2006. If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. S. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Contemporary Clinical Neuroscience Totowa, NJ: Humana Press. , pp.69-83. (10.1007/978-1-59745-058-4_4)
- Humby, T. , Wilkinson, L. S. and Dawson, G. 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. In: Current Protocols in Neuroscience. Chichester: Wiley(10.1002/0471142301.ns0805hs31)
Research
My research focus is on the rapidly evolving field of behavioural genetics/epigenetics, with an emphasis on cognition. Current main research interests include work on Alzheimer's disease and other dementias; gene variants influencing attention and impulsive responding; novel X-linked effects on behaviour; and genomic imprinting effects on cognition and behaviour.
Recent key findings includes evidence that tau irregularities in AD may be linked to abnormal processing of APP C-terminal fragments via specific effects on MAPK activation, evidence for tauopathy effects on frontal functioning mediated by changes in serotonin neurochemistry, new autosomal and X-linked genetic mechanisms influencing fear, attention and impulsive behaviour and the discovery of X-linked imprinted gene effects on cognitive function.
Supervisions
Postgraduate research interests
If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.
Contact Details
[email protected]
+44 29208 70357
Tower Building, 70 Park Place, Cardiff, CF10 3AT
Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
+44 29208 70357
Tower Building, 70 Park Place, Cardiff, CF10 3AT
Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
