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Dr Wayne Nishio
(e/fe)
BEng (Hons) PhD SFHEA
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Wayne Nishio
Uwch-ddarlithydd mewn Biomaterials
Trosolwyg
Fy uchelgais yw dod yn academydd sefydledig ym maes bioddeunyddiau, trwy ddarparu rhagoriaeth ymchwil ac addysgu effaith uchel. Fi yw arweinydd y Grŵp Ymchwil Biomaterials yn yr Ysgol Deintyddiaeth, Prifysgol Caerdydd a chyfarwyddwr y rhaglen MSc Peirianneg Meinweoedd a Meddygaeth Adfywiol. Mae fy niddordebau ymchwil yn cynnwys: dylunio, datblygu a phrofi dyfeisiau meddygol a bioddeunyddiau; mabwysiadu dull rhyngddisgyblaethol o ymchwilio drwy gydweithio gwyddonol academaidd a diwydiannol; deall a gwella darpariaeth cyffuriau ac agweddau gwrthficrobaidd ar fioddeunyddiau; deall a gwella'r rhyngweithio rhwng dyfeisiau meddygol, meinweoedd a chelloedd. Mae fy meysydd diddordeb penodol yn troi o gwmpas defnyddio haenau lipid a systemau cyflwyno i wella osseointegration ac atal heintiau deunyddiau orthopedig a deintyddol.
Arbenigedd
- Cyflenwi cyffuriau o fiomaterials
- Systemau cyflenwi liposomaidd
- Caenau mewnblaniad orthopedig a deintyddol a thopograffïau
- Prince2 Rheoli Prosiect Ystwyth: Sylfaen ac Ymarferydd
Cyhoeddiad
2026
- Davies-Jones, J. A. et al., 2026. Unravelling nanoscale chemistries in complex biological systems using photoinduced force microscopy (PiFM). Faraday Discussions 265 , pp.56-75. (10.1039/d5fd00141b)
- Bolzoni, L. et al., 2026. Low-cost Ti alloys: assessment of their microstructure, mechanical properties, corrosion behaviour, and biological response. Journal of the Mechanical Behavior of Biomedical Materials 178 107411. (10.1016/j.jmbbm.2026.107411)
2025
- Hawia, S. et al., 2025. Antibacterial and osseointegration evaluation of silver ion implanted orthopaedic implants. Journal of Micromanufacturing (10.1177/25165984251382378)
- Li, J. et al., 2025. AMY-101 as complement C3 inhibitor for periodontitis therapy: Mechanisms, efficacy, and clinical translation. Frontiers in Immunology 16 1587126. (10.3389/fimmu.2025.1587126)
- Tao, Y. et al., 2025. Enhanced functionalities of biomaterials through metal ion surface modification. Frontiers in Bioengineering and Biotechnology 13 1522442. (10.3389/fbioe.2025.1522442)
- Hawi, S. et al., 2025. Precision laser manufacturing and metrology of nature-inspired bioactive surfaces for antibacterial medical implants. Surfaces and Interfaces 62 106267. (10.1016/j.surfin.2025.106267)
2024
- Green, T. et al. 2024. Laser surface texturing of bulk metallic glass for orthopaedic application. Presented at: School of Engineering Research Conference 2024 Cardiff, UK 12-14 June 2024. Published in: Spezi, E. and Bray, M. eds. Proceedings of the Cardiff University School of Engineering Research Conference 2024.. Cardiff, Wales: Cardiff University Press. (10.18573/conf3.b)
- Azizova, L. et al. 2024. Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science 665 160337. (10.1016/j.apsusc.2024.160337)
- Jagannathan, C. , Waddington, R. and Nishio Ayre, W. 2024. Nanoparticle and nanotopography-induced activation of the Wnt pathway in bone regeneration. Tissue Engineering Part B: Reviews 30 (2), pp.270-283. (10.1089/ten.TEB.2023.0108)
2023
- Mason, B. et al. 2023. Development of a novel laser polishing strategy for additively manufactured AlSi10Mg alloy parts. Presented at: 9th International Conference on Sustainable Design and Manufacturing - SDM 2022 Split, Croatia 16-17 September 2022. Published in: Scholz, S. , Howlett, R. and Setchi, R. eds. Sustainable Design and Manufacturing. Vol. 338.Smart Innovation, Systems and Technologies Singapore: Springer. , pp.272-282. (10.1007/978-981-19-9205-6_26)
2022
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604 154462. (10.1016/j.apsusc.2022.154462)
- Britton, S. et al., 2022. Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus. Scientific Reports 12 (1) 16661. (10.1038/s41598-022-20310-8)
- Sadaghiani, L. et al. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S. et al., 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5 (1), pp.1-17. (10.1021/acsanm.1c03045)
2021
- Larrañaga-Altuna, M. et al., 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8 (2) 021303. (10.1063/5.0028844)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547 149194. (10.1016/j.apsusc.2021.149194)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35 (10), pp.1235-1252. (10.1177/0885328220983797)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11 111. (10.1186/s13578-021-00580-x)
2020
- Jiang, L. et al., 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J. et al. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6 (10) 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al., 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23 , pp.140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J. et al. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26 (3), pp.217-229. (10.1089/ten.teb.2019.0312)
2019
- Beamish, R. , Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress London, England 10-13 October 2018. Vol. 101-B.Vol. S5. British Editorial Society of Bone and Joint Surgery. , pp.111.
2018
- Blaikie, P. et al. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR London, UK 25-28 Jul 2018.
- Melling, G. et al. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24 (13-14), pp.1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86 (5) e00871-17. (10.1128/IAI.00871-17)
- Williams, R. et al., 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting Estoril, Portugal 10-12 September 2015. Vol. 97-B.Vol. SUPP_1. (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
2017
- Quiney, D. , Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62 , pp.64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L. et al., 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32 (3), pp.953-957. (10.1016/j.arth.2016.09.010)
2016
- Nishio Ayre, W. et al. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104 (8), pp.1510-1524. (10.1002/jbm.b.33488)
- Sloan, A. et al. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons. , pp.96-109. (10.1002/9781119282181.ch5)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53 , pp.64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W. et al. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27 36. (10.1007/s10856-015-5644-7)
2015
- Lee, C. P. et al., 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6 , pp.1-13. (10.1177/2041731415586318)
2014
- Nishio Ayre, W. , Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32 , pp.76-88. (10.1016/j.jmbbm.2013.12.010)
2013
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis , Cardiff University.
2012
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B (SXVIII), pp.63-63.
2010
- Ayre, W. et al. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering Valencia, Spain
Adrannau llyfrau
- Sloan, A. et al. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons. , pp.96-109. (10.1002/9781119282181.ch5)
Cynadleddau
- Green, T. et al. 2024. Laser surface texturing of bulk metallic glass for orthopaedic application. Presented at: School of Engineering Research Conference 2024 Cardiff, UK 12-14 June 2024. Published in: Spezi, E. and Bray, M. eds. Proceedings of the Cardiff University School of Engineering Research Conference 2024.. Cardiff, Wales: Cardiff University Press. (10.18573/conf3.b)
- Mason, B. et al. 2023. Development of a novel laser polishing strategy for additively manufactured AlSi10Mg alloy parts. Presented at: 9th International Conference on Sustainable Design and Manufacturing - SDM 2022 Split, Croatia 16-17 September 2022. Published in: Scholz, S. , Howlett, R. and Setchi, R. eds. Sustainable Design and Manufacturing. Vol. 338.Smart Innovation, Systems and Technologies Singapore: Springer. , pp.272-282. (10.1007/978-981-19-9205-6_26)
- Beamish, R. , Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress London, England 10-13 October 2018. Vol. 101-B.Vol. S5. British Editorial Society of Bone and Joint Surgery. , pp.111.
- Blaikie, P. et al. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR London, UK 25-28 Jul 2018.
- Williams, R. et al., 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting Estoril, Portugal 10-12 September 2015. Vol. 97-B.Vol. SUPP_1. (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
- Ayre, W. et al. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering Valencia, Spain
Erthyglau
- Davies-Jones, J. A. et al., 2026. Unravelling nanoscale chemistries in complex biological systems using photoinduced force microscopy (PiFM). Faraday Discussions 265 , pp.56-75. (10.1039/d5fd00141b)
- Bolzoni, L. et al., 2026. Low-cost Ti alloys: assessment of their microstructure, mechanical properties, corrosion behaviour, and biological response. Journal of the Mechanical Behavior of Biomedical Materials 178 107411. (10.1016/j.jmbbm.2026.107411)
- Hawia, S. et al., 2025. Antibacterial and osseointegration evaluation of silver ion implanted orthopaedic implants. Journal of Micromanufacturing (10.1177/25165984251382378)
- Li, J. et al., 2025. AMY-101 as complement C3 inhibitor for periodontitis therapy: Mechanisms, efficacy, and clinical translation. Frontiers in Immunology 16 1587126. (10.3389/fimmu.2025.1587126)
- Tao, Y. et al., 2025. Enhanced functionalities of biomaterials through metal ion surface modification. Frontiers in Bioengineering and Biotechnology 13 1522442. (10.3389/fbioe.2025.1522442)
- Hawi, S. et al., 2025. Precision laser manufacturing and metrology of nature-inspired bioactive surfaces for antibacterial medical implants. Surfaces and Interfaces 62 106267. (10.1016/j.surfin.2025.106267)
- Azizova, L. et al. 2024. Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science 665 160337. (10.1016/j.apsusc.2024.160337)
- Jagannathan, C. , Waddington, R. and Nishio Ayre, W. 2024. Nanoparticle and nanotopography-induced activation of the Wnt pathway in bone regeneration. Tissue Engineering Part B: Reviews 30 (2), pp.270-283. (10.1089/ten.TEB.2023.0108)
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604 154462. (10.1016/j.apsusc.2022.154462)
- Britton, S. et al., 2022. Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus. Scientific Reports 12 (1) 16661. (10.1038/s41598-022-20310-8)
- Sadaghiani, L. et al. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S. et al., 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5 (1), pp.1-17. (10.1021/acsanm.1c03045)
- Larrañaga-Altuna, M. et al., 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8 (2) 021303. (10.1063/5.0028844)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547 149194. (10.1016/j.apsusc.2021.149194)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35 (10), pp.1235-1252. (10.1177/0885328220983797)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11 111. (10.1186/s13578-021-00580-x)
- Jiang, L. et al., 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J. et al. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6 (10) 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al., 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23 , pp.140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J. et al. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26 (3), pp.217-229. (10.1089/ten.teb.2019.0312)
- Melling, G. et al. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24 (13-14), pp.1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86 (5) e00871-17. (10.1128/IAI.00871-17)
- Quiney, D. , Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62 , pp.64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L. et al., 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32 (3), pp.953-957. (10.1016/j.arth.2016.09.010)
- Nishio Ayre, W. et al. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104 (8), pp.1510-1524. (10.1002/jbm.b.33488)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53 , pp.64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W. et al. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27 36. (10.1007/s10856-015-5644-7)
- Lee, C. P. et al., 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6 , pp.1-13. (10.1177/2041731415586318)
- Nishio Ayre, W. , Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32 , pp.76-88. (10.1016/j.jmbbm.2013.12.010)
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B (SXVIII), pp.63-63.
Gosodiad
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis , Cardiff University.
Ymchwil
Cyllid ymchwil
2024 - Cronfa Sbarduno Cydweithredol Partneriaeth Ryngwladol Strategol Prifysgol Caerdydd a Phrifysgol Waikato" - £6,000. Gorffennaf 2024. Prif ymgeisydd.
2023 - Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "ExoView R200 – Nodweddu a dadansoddi'r genhedlaeth nesaf o fesiglau a nanoronynnau allgellog. £107,249. Mai 2023. Cyd-ymgeisydd.
2023 - Galwad Offer Craidd EPSRC "Galwad Offer EPSRC 2022 - Prifysgol Caerdydd". £757,080. Ionawr 2023. Cyd-ymgeisydd.
2023 – Ysgoloriaeth EPSRC DTP "Arwynebau mewnblaniad gwydr metelaidd swmp gwrthficrobaidd ac adfywiol laser". £81,924. Hydref 2023. Prif ymgeisydd.
2022 – Rhaglen Sêr Cymru – Gwobr Offer Gwella Cystadleurwydd. "Circular Hybrid Manufacturing (CHM) of sustainable powders for powder-bed-fusion additive manufacturing (AM) processes through recycling of machining scraps". £54,136. Ionawr 2023. Cyd-ymgeisydd.
2022 - Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Peiriant gweithgynhyrchu ychwanegion jetio rhwymwr metel". £350,400. Mai 2022. Cyd-ymgeisydd
2022 - BBSRC Datblygu technolegau sylfaenol mewn synhwyro a delweddu. "Datblygu offeryn delweddu sbectrosgopeg nanoraddfa, agos at is-goch ar gyfer dadansoddiad in situ, cyflym a heb label o fesiglau allgellog sengl". £226,242. Ebrill 2023. Prif ymgeisydd.
2021 – Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Spectroscopy of interfaces". £455,000. Ebrill 2022. Cyd-ymgeisydd
2021 - Offer Strategol EPSRC. "Microsgopeg Grym a achosir gan ffotograffau (PiFM): Topograffeg Nanoscale a Sbectrosgopeg Dirgrynol". £1,013,903. Ebrill 2022. Cyd-ymgeisydd.
2021 – Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Labordy Gwydnwch a Nodweddu". £383,000. Medi 2021. Cyd-ymgeisydd
2021 – GlaxoSmithKline. "Comparative evaluation of toothpaste/brushing efficacy in a relevant model system". £29,788. Gorffennaf 2021. Cyd-ymgeisydd
2020 – Gwobr Ymchwilydd Newydd EPSRC. ↑ "Exploiting bacterial virulence to trigger antimicrobial release from orthopaedic implants". £264,217. Ebrill 2021. Prif ymgeisydd.
2019 - Offer Sefydliadol EPSRC ECR. £ 48,000. Ionawr 2019. Prif ymgeisydd.
2018 – Yn erbyn Ysgoloriaeth PhD Arthritis . ↑ "A novel antibacterial titanium implant technology for total joint arthroplasty". £111,085. January 2019. Co-applicant.
2018 – Ymddiriedolaeth Wellcome ISSF3 – "Arwynebau mewnblaniad gwrthficrobaidd ac osteogenig newydd wedi'u sinterio â laser gan ddefnyddio micro/nano-topograffeg wedi'u ablated â laser ultra byr". £49,933. Ebrill 2018. Prif ymgeisydd.
2017 – Hyder MRC mewn Cysyniad - "Gorchudd lipid cadarn a hawdd i wella iro a lleihau ffurfio bioffilm ar catheters wrinol". £62,427. Awst 2017. Prif ymgeisydd.
2017 – Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Spark Plasma Sintering (SPS) system". £179,000. Ebrill 2017. Cyd-ymgeisydd
2016 – Cais Offer Ymchwil a Datblygu y GIG "Argraffydd 3D". £8,000 Chwefror 2016. Prif ymgeisydd.
2016 – Cronfa Bontio Gwyddorau Bywyd "Optimisation and toxicity testing of the liposomal drug delivery system for orthopaedic bone cement". £71,114. Ionawr 2017. Prif ymgeisydd.
2016 – ISSF Ymddiriedolaeth Wellcome "Gwella priodweddau gwisgo cwpanau acetabular CRF-PEEK a UHMWPE gan ddefnyddio swyddogaethu arwyneb dwyhaen lipid newydd." £23,067 Gorffennaf 2016. Prif ymgeisydd.
2016 – Cais Offer Ymchwil a Datblygu y GIG "Anweddydd Rotari". £5,738 Chwefror 2017. Prif ymgeisydd.
2015 – Ymddiriedolaeth Feddygol Dunhill – "Atal llacio aseptig o amnewidiadau cymalau smentiedig mewn oedolion hŷn: cyflwyno moleciwlau osteogenig o sment esgyrn PMMA i annog atgyweirio esgyrn a mewnblaniad osseointegration". £86,104 Chwefror 2015 – Awst 2016. Cyd-ymgeisydd.
2015 – NIHR i4i – "Biofunctionalization fluorophosphonate of biomaterials for orthopaedic applications". £372,480 Medi 2015 – Awst 2017. Cyd-ymgeisydd.
2015 – Cynllun Agosrwydd at Ddarganfod MRC – "Sgaffaldiau dentine biomimetig, gwrthficrobaidd a bioactif newydd ar gyfer therapïau mwydion hanfodol". £20,000 Hydref 2015 – Rhagfyr 2015. Prif ymgeisydd.
2014 - Ysgoloriaeth PhD Renishaw – "Adlyniad ac ataliad bacteriol ar arwynebau mewnblaniad deintyddol ac abutment". £50,000 Hydref 2015 – 2018. Cyd-ymgeisydd.
2014 - Prosiect Ymchwil Rhwydwaith Ymchwil Gwyddorau Bywyd Cymru – "Cyflenwi moleciwlau osteogenig o sment esgyrn acrylig i annog atgyweirio esgyrn adfywiol o amgylch amnewidiadau cymalau wedi'u smentio". £49,929 Chwefror 2015 – 2016. Prif ymgeisydd.
2014 - Cynllun Her Technoleg Iechyd SARTRE – "System gyflenwi gwrthficrobaidd liposomaidd ar gyfer sment esgyrn PMMA". £19,635 Gorffennaf – Medi 2014. Prif ymgeisydd.
Patentau
- Denyer S, Evans S, Ayre W. System cyflenwi cyffuriau liposomaidd ar gyfer smentiau esgyrn. Rhif Patent Rhyngwladol: WO 2015004450 A1.
Mynediad at gyfleusterau
- Profion mecanyddol a blinder (profwr caledwch Lloyd LR10K, LRX, LFPlus, Mitutoyo MVK-G1)
- Rheoleg (Bohlin C-VOR200, viscomedr cylchdro Cole-Parmer)
- Proffilometreg (Mitutoyo Surftest SV-2000, Taicaan XYRIS)
- Colorimetreg (Konica Minolta CM-700D, Dr Lange Micro Lliw II)
- Ongl gyswllt (Cahn DCA-312, Attension Theta Lite)
- Microbalance grisial chwarts (MicroVacuum QCM-I)
- Fformiwla liposom (Buchi Rotavapor R-300, Allwthiwr Lipex)
- Dadansoddiad thermol mecanyddol deinamig (DMTA Gwyddonol Rheometrig Mk III)
- Argraffu 3D (Asiga Pico 2, Motionview iPrint 3D)
- FTIR (Nicolet 380 FT-IR)
- Torri sampl (Logitech AXL1 Annular Saw, South Bay 650)
- qRT-PCR (QuantStudio 6)
- Microsgopeg electron sganio (Tescan VEGA SEM-XRMA)
- Microsgopeg Confocal (Leica TCS SP5)
- Microbioleg
- Diwylliant meinwe
- Histoleg
- MicroCT (Bruker Skyscan 1272 - MSKBRF, Ysgol Peirianneg)
Addysgu
Addysgu israddedig
Llawfeddygaeth Ddeintyddol (BDS), Therapi Deintyddol a Hylendid Deintyddol (BSc) - Deunyddiau Deintyddol Blwyddyn 2
- Arweinydd pwnc ar gyfer Bioddeunyddiau Deintyddol
- Cyflwyno darlithoedd ar biogydnawsedd, priodweddau deunyddiau, polymerau a meteleg.
- Arwain ar sesiynau ymarferol deunydd cyfansawdd a deintyddol.
- Gosod/asesu arholiadau BDS Cynradd, BDS Canolradd a BDS Terfynol.
- Gosod/asesu posteri Blwyddyn 2, cyflwyniadau llafar a thraethodau estynedig
- Tiwtor academaidd a phersonol.
Llawfeddygaeth Ddeintyddol (BDS) - Prosiectau Blwyddyn Olaf Blwyddyn 4/5
- Goruchwylio prosiectau labordy.
- Asesu adroddiadau prosiect blwyddyn olaf.
Addysgu ôl-raddedig
Peirianneg Meinweoedd a Meddygaeth Adfywiol (MSc)
- Cyfarwyddwr Peirianneg Meinwe a Meddygaeth Adfywiol MSc.
- Goruchwylio prosiectau myfyrwyr MSc.
- Asesu traethodau ymchwil prosiect MSc a chyflwyniadau llafar/posteri.
Bioleg y Geneuol (MSc)
- Cyflwyno darlithoedd ar fioleg celloedd a matrics, grymoedd biomecanyddol ac ymateb meinweoedd i fiodeunyddiau.
- Gosod/asesu cyflwyniadau llafar, traethodau estynedig a chwestiynau arholiad.
- Goruchwylio prosiectau myfyrwyr MSc.
Myfyrwyr PhD
- Goruchwylio myfyrwyr PhD ar draws yr Ysgolion Deintyddiaeth, Fferylliaeth a Gwyddorau Fferyllol a Pheirianneg.
Cymwysterau
Uwch Gymrawd yr Academi Addysg Uwch (SFHEA)
Bywgraffiad
Trosolwg gyrfa
- Medi 2021 - Yn bresennol: Uwch Ddarlithydd mewn Biomaterials – Ysgol Deintyddiaeth Caerdydd.
- Medi 2016 – Awst 2021: Darlithydd mewn Biomaterials – Ysgol Deintyddiaeth Caerdydd.
- Tachwedd 2014 – Medi 2016: Cymrawd ymchwil – Ysgol Deintyddiaeth Caerdydd, Peirianneg Meinwe a Deintyddiaeth Adferol. Rhwydwaith Ymchwil Gwyddorau Bywyd Cymru: Cyflwyno moleciwlau osteogenig o sment esgyrn acrylig i annog atgyweirio esgyrn atgynhyrchiol o amgylch amnewidiadau ar y cyd wedi'u smentio.
- Medi 2014 – Tachwedd 2014: Cydymaith ymchwil – Ysgol Fferylliaeth Caerdydd a'r Gwyddorau Fferyllol. Prosiect Peilot Bio-E SATRTE: Titaniwm sy'n swyddogaethol asid lysophosphatidic wedi'i deipio ffosffonate: gorffeniad wyneb newydd ar gyfer cymwysiadau adfywiol esgyrn.
- Mehefin 2014 – Awst 2014: Cyswllt ymchwil – Ysgol Fferylliaeth a Gwyddorau Fferyllol Caerdydd. Prosiect Peilot Her Technoleg Iechyd SATRTE: System gyflenwi gwrthficrobaidd liposomal ar gyfer sment esgyrn PMMA
- Rhagfyr 2013 – Mai 2014: Cydymaith ymchwil – Ysgol Deintyddiaeth, Peirianneg Meinwe a Deintyddiaeth Atgyweiriol. Ymddiriedolaeth Feddygol Dunhill: Atal poen deintyddol, crawniadau a cholli dannedd mewn oedolion hŷn: datblygu deunyddiau adferol gwrthficrobaidd i reoli clefyd deintyddol mewn oedolion hŷn
- Medi 2013 – Tachwedd 2013: Cynorthwy-ydd Ymchwil – Ysgol Peirianneg Caerdydd, Sefydliad Peirianneg Fecanyddol a Gweithgynhyrchu. Comisiwn Sky / UE Glân: Datblygu, gweithgynhyrchu a phrofi deunyddiau cyfansawdd ar gyfer cymwysiadau awyrofod.
Addysg a chymhwyster
- 2009 – 2013: Doethur mewn Athroniaeth (PhD) mewn Peirianneg Fecanyddol, Prifysgol Caerdydd/Arthritis Research UK Biomechanics and Bioengineering Centre. Prosiect ymchwil rhyngddisgyblaethol rhwng ysgolion Peirianneg a Fferylliaeth, gan ddatblygu a phrofi fformwleiddiadau newydd o sment esgyrn PMMA i wella priodweddau mecanyddol, cyffuriau ac osseointegrative.
- 2006 – 2009: Baglor Peirianneg (B.Eng. Dosbarth Cyntaf Anrh) mewn Peirianneg Feddygol, Ysgol Peirianneg, Prifysgol Caerdydd
Anrhydeddau a dyfarniadau
- 2017 - Crucible Cymru - Rhaglen Arweinwyr Ymchwil Cymru y Dyfodol
- 2016 – Cymdeithas Ymchwil Orthopedig Prydain – Cymrodoriaeth Teithio Rhyngwladol
- 2015 – Rhwydwaith Ymchwil Gwyddorau Bywyd Cymru: 2il Gyngres Darganfod Cyffuriau – Cyflwyniad Ôl-ddoethurol Gorau
- 2015 – Gwobr Ymchwilydd Ifanc Sefydliad y Meinwe a Thrwsio
- 2014 – Gwobr IADR-PER GSK-MINERALISED TISSUE GROUP.
- 2014 – Gwobr Anrhydeddus Cwmni Peirianwyr Mercia mewn Peirianneg Feddygol.
- 2014 – Bwrsariaeth Teithio Sefydliad Meinweoedd a Pheirianneg Meinweoedd Caerdydd.
- 2013 – Gwobr Poster Academy of Pharmaceutical Sciences (PharmSci) a noddir gan GlaxoSmithKline (GSK).
- 2010 a 2013 – Gwobr Teithio William Norman Thomas Sefydliad Peirianneg De Cymru (SWIEET).
- 2006 – Gwobr Prosiect 3edd flwyddyn y Sefydliad Peirianneg Fecanyddol (IMechE).
- 2006 – Gwobr Ysgol Beirianneg Caerdydd Ysgol MMM School.
Aelodaethau proffesiynol
- Aelod o'r Gymdeithas Ryngwladol ar gyfer Ymchwil Ddeintyddol/Cymdeithas Brydeinig ar gyfer Ymchwil Llafar a Deintyddol.
- Aelod o Gymdeithas Ymchwil Orthopedig Prydain.
- Aelod o Sefydliad Peirianneg ac Atgyweirio Meinwe Caerdydd.
Pwyllgorau ac adolygu
- Golygydd Arbenigol ar gyfer Ymchwil Esgyrn a Chydweithredol
- Adolygydd Meddygaeth Ddeintyddol Frontiers a Frontiers Technoleg Meddygol
- Adolygydd grant ar gyfer EPSRC/BBSRC/MRC
- Pwyllgor Gwaith Peirianneg a Thrwsio Meinwe Caerdydd
- Gweithredwr Rhwydwaith Ymchwil Deunyddiau Caerdydd
- Biomecaneg a'r Ganolfan Biobeirianneg yn erbyn Pwyllgor Gweithredol Arthritis
- Arweinydd Gyrfaoedd a Chyflogadwyedd yr Ysgol Deintyddiaeth
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PhD ym meysydd:
- Modelau in vitro o'r ymateb imiwnedd gwesteiwr i fiomaterials
- Cyflwyno gwrthficrobaidd liposomaidd i atal a thrin clefydau heintus
- Cyflwyno ffactor twf liposomaidd i annog osteogenesis
- Haenau mewnblaniad lipid gwrthficrobaidd seiliedig ar lipid
- Topograffïau mewnblaniad osteogenig a gwrthficrobaidd
- Cyflwyno cyffuriau o sment asgwrn PMMA
Cyfleoedd PhD cyfredol:
- Datblygu model in vitro o'r ymateb imiwnedd gwesteiwr i fiomaterials
- Gwneud esgyrn wedi torri yn wrthficrobaidd: Atal osteomyelitis gan ddefnyddio system gyflenwi liposomaidd wedi'i thargedu a'i fwynhau
- Laser newydd ablated arwynebau mewnblannu micro / nano ar gyfer cyflwyno therapiwteg gwrthficrobaidd ac osteogenig
- Datblygu fformwleiddiadau liposomaidd i oresgyn mecanweithiau ymwrthedd gwrthfiotig
Goruchwyliaeth gyfredol
Prosiectau'r gorffennol
Myfyrwyr PhD
- Savannah Britton - technoleg mewnblannu titaniwm gwrthfacterol newydd ar gyfer cyfanswm arthroplasti ar y cyd (parhaus)
- Peter Hansal - Optimeiddio a gwella system gyflenwi liposomaidd (gwobrwywyd 2022)
- Clotilde Haury - Ymlyniad pathogenau peri-mewnblannu i ategion toddi laser a datblygu cotio gwrthficrobaidd newydd (gwobrwywyd 2019)
- Madhan Natarajan - Nodweddu ymatebion mwydion i her bacteriol a gwrthficroborau newydd ar gyfer rheoli halogiad bacteriol o fwydion heintiedig (gwobrwywyd 2018)
Myfyrwyr MSc
- Yimin Ge - Effaith phosphatidylserine, phosphatidylethalonamine a liposomau phosphatidylcholine ar wahaniaethu osteogenig celloedd strêr esgyrn dynol (gwobrwywyd 2023)
- Gisselle Montenegro - mynegiant derbynnydd Phosphatidylserine, lleoleiddio ac actifadu mewn celloedd strêr mêr esgyrn dynol (gwobrwywyd 2022)
- Thomas Green - Modiwleiddio'r ymateb gwesteiwr i fewnblaniadau orthopedig gan ddefnyddio laser pwls ultra-fer blated micro/nano-topograffïau (gwobrwywyd 2022)
- James Adams - Gwrthweithyddion derbynyddion glwtamad ar gyfer trin clefyd periodontal (gwobrwywyd 2022)
- Marella Cuevas - mynegiant derbynnydd Phosphatidylserine, lleoleiddio ac actifadu mewn celloedd MG-63 wedi'u trin â liposomau (gwobrwywyd 2021)
- Sarah Jefferies - Gwrthweithyddion derbynnydd glwtamad ar gyfer trin clefyd periodontal (gwobrwywyd 2021)
- Chitra Jagannathan - actifadu Nanoparticle a nanotopograffi ar lwybr signalau Wnt wrth adfywio esgyrn: Adolygiad o'r llenyddiaeth (gwobrwywyd 2020)
- Lujien Dribika - Cyflwyno liposomaidd o ffactorau twf ar gyfer atgyweirio meinwe mwynol gwell (gwobrwywyd 2020)
- Rawan Abu Dagga - Swyddogaethau biolegol a mecanweithiau gweithredu phosphatidylserine mewn atgyweirio esgyrn (dyfarnwyd 2020)
- Yumeng Guo - Modelau in vitro i astudio'r ymateb imiwnedd gwesteiwr i heintiau bioddeunydd (dyfarnwyd 2020)
- Abdullah Alshumrani - Ymddygiad celloedd progenitor mwydion deintyddol wedi'u diwyllo ar arwynebau dentin cyflyredig (gwobrwywyd 2019)
- Liam O'Brien - Eludicating mecanweithiau gweithredu gwrth-lynol cotio mewnblaniad orthopedig FHBP yn erbyn ynysigau clinigol Staphylococcus aureus (gwobrwywyd 2019)
- Maria Suarez Arocena - Ymateb mwydion deintyddol i hydrogen perocsid a'i botensial wrth drin caris deintyddol (gwobrwywyd 2018)
- Yingke Cai - Gwrthweithyddion cludwr glutamad ar gyfer trin clefyd periodontal (gwobrwywyd 2018)
- Ana Springall de Pablo - Datblygu model ar y cyd ex vivo i astudio heintiau prosthetig sy'n gysylltiedig â bioffilm (gwobrwywyd 2017)
- Miles Thompson - Effaith zoledronate liposomal ar bolareiddio macrophage a phagocytosis haint sy'n gysylltiedig â mewnblaniad Staphylococcus aureus (gwobrwywyd 2017)
- Rebecca Beamish - Cyflwyno gwrthfiotigau o sment esgyrn liposomal ostegenig (gwobrwywyd 2016)
Contact Details
[email protected]
+44 29225 10660
Ysbyty Deintyddol y Brifysgol, Ystafell 5F.06 Swyddfa Ymchwil Ôl-raddedig, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
+44 29225 10660
Ysbyty Deintyddol y Brifysgol, Ystafell 5F.06 Swyddfa Ymchwil Ôl-raddedig, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
Themâu ymchwil
Arbenigeddau
- Biomaterialau
- Orthopedeg
- Cyflwyno cyffuriau
- Topograffïau mewnblannu
- Lipids