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Dr Wayne Nishio
(e/fe)
BEng (Hons) PhD FHEA
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Wayne Nishio
Uwch-ddarlithydd mewn Biomaterials
Trosolwyg
Fy uchelgais yw dod yn academydd sefydledig ym maes bioddeunyddiau, trwy ddarparu rhagoriaeth ymchwil ac addysgu effaith uchel. Fi yw arweinydd y Grŵp Ymchwil Biomaterials yn yr Ysgol Deintyddiaeth, Prifysgol Caerdydd a chyfarwyddwr y rhaglen MSc Peirianneg Meinweoedd a Meddygaeth Adfywiol. Mae fy niddordebau ymchwil yn cynnwys: dylunio, datblygu a phrofi dyfeisiau meddygol a bioddeunyddiau; mabwysiadu dull rhyngddisgyblaethol o ymchwilio drwy gydweithio gwyddonol academaidd a diwydiannol; deall a gwella darpariaeth cyffuriau ac agweddau gwrthficrobaidd ar fioddeunyddiau; deall a gwella'r rhyngweithio rhwng dyfeisiau meddygol, meinweoedd a chelloedd. Mae fy meysydd diddordeb penodol yn troi o gwmpas defnyddio haenau lipid a systemau cyflwyno i wella osseointegration ac atal heintiau deunyddiau orthopedig a deintyddol.
Arbenigedd
- Cyflenwi cyffuriau o fiomaterials
- Systemau cyflenwi liposomaidd
- Caenau mewnblaniad orthopedig a deintyddol a thopograffïau
- Prince2 Rheoli Prosiect Ystwyth: Sylfaen ac Ymarferydd
Cyhoeddiad
2024
- Green, T., Nishio, W., Bigot, S., Brousseau, E. and Bhaduri, D. 2024. Laser surface texturing of bulk metallic glass for orthopaedic application. Presented at: School of Engineering Research Conference 2024, Cardiff, UK, 12-14 June 2024 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardiff University School of Engineering Research Conference 2024.. Cardiff, Wales: Cardiff University Press, (10.18573/conf3.b)
- Azizova, L., Al Dalaty, A., Brousseau, E., Birchall, J., Wilkinson, T., Sloane, A. and Nishio Ayre, W. 2024. Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science 665, article number: 160337. (10.1016/j.apsusc.2024.160337)
- Jagannathan, C., Waddington, R. and Nishio Ayre, W. 2024. Nanoparticle and nanotopography-induced activation of the Wnt pathway in bone regeneration. Tissue Engineering Part B: Reviews 30(2), pp. 270-283. (10.1089/ten.TEB.2023.0108)
2022
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604, article number: 154462. (10.1016/j.apsusc.2022.154462)
- Britton, S., Lee, K., Azizova, L., Shaw, G., Nishio Ayre, W. and Mansell, J. P. 2022. Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus. Scientific Reports 12(1), article number: 16661. (10.1038/s41598-022-20310-8)
- Sadaghiani, L., Alshumrani, A. M., Gleeson, H., Nishio Ayre, W. and Sloan, A. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S., Goel, S., Kumar, V., Pearce, O., Nishio Ayre, W. and Ivanova, E. P. 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5(1), pp. 1-17. (10.1021/acsanm.1c03045)
- Mason, B., Ryan, M., Setchi, R., Kundu, A., Nishio Ayre, W. and Bhaduri, D. 2022. Development of a novel laser polishing strategy for additively manufactured AlSi10Mg alloy parts. Presented at: 9th International Conference on Sustainable Design and Manufacturing - SDM 2022, Split, Croatia, 16-17 September 2022.
2021
- Larrañaga-Altuna, M. et al. 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8(2), article number: 21303. (10.1063/5.0028844)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547, article number: 149194. (10.1016/j.apsusc.2021.149194)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35(10), pp. 1235-1252. (10.1177/0885328220983797)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11, article number: 111. (10.1186/s13578-021-00580-x)
2020
- Jiang, L., Nishio Ayre, W., Melling, G. E., Song, B., Wei, X., Sloan, A. and Chen, X. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J., Khor, C., Nishio Ayre, W., Doyle, Z. and Chadwick, E. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6(10), article number: 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al. 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23, pp. 140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J., Ayre, W. N., Sloan, A. J. and Waddington, R. J. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26(3), pp. 217-229. (10.1089/ten.teb.2019.0312)
2019
- Beamish, R., Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress, London, England, 10-13 October 2018, Vol. 101-B. Vol. Supple. British Editorial Society of Bone and Joint Surgery, (10.1302/1358-992X.2019.5.111)
2018
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
- Melling, G., Colombo, J. S., Avery, S., Nishio Ayre, W., Evans, S. L., Waddington, R. and Sloan, A. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24(13-14), pp. 1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86(5), article number: e00871-17. (10.1128/IAI.00871-17)
- Williams, R., Khan, W., Williams, H., Abbas, A., Mehta, A., Ayre, W. and Morgan-Jones, R. 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting, Estoril, Portugal, 10-12 September 2015, Vol. 97-B. Vol. SUPP_1., (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
2017
- Quiney, D., Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62, pp. 64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L., Nishio Ayre, W., Khan, W. S., Mehta, A. and Morgan-Jones, R. 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32(3), pp. 953-957. (10.1016/j.arth.2016.09.010)
2016
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Sloan, A., Colombo, J., Roberts, J., Waddington, R. and Nishio Ayre, W. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons, pp. 96-109., (10.1002/9781119282181.ch5)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53, pp. 64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
2015
- Lee, C. P., Colombo, J. S., Nishio Ayre, W., Sloan, A. J. and Waddington, R. J. 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6, pp. 1-13. (10.1177/2041731415586318)
2014
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
2013
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
2012
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
2010
- Ayre, W., Howell, M., Madete, J. K., Jones, D. K. and Holt, C. A. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Adrannau llyfrau
- Sloan, A., Colombo, J., Roberts, J., Waddington, R. and Nishio Ayre, W. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons, pp. 96-109., (10.1002/9781119282181.ch5)
Cynadleddau
- Green, T., Nishio, W., Bigot, S., Brousseau, E. and Bhaduri, D. 2024. Laser surface texturing of bulk metallic glass for orthopaedic application. Presented at: School of Engineering Research Conference 2024, Cardiff, UK, 12-14 June 2024 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardiff University School of Engineering Research Conference 2024.. Cardiff, Wales: Cardiff University Press, (10.18573/conf3.b)
- Mason, B., Ryan, M., Setchi, R., Kundu, A., Nishio Ayre, W. and Bhaduri, D. 2022. Development of a novel laser polishing strategy for additively manufactured AlSi10Mg alloy parts. Presented at: 9th International Conference on Sustainable Design and Manufacturing - SDM 2022, Split, Croatia, 16-17 September 2022.
- Beamish, R., Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress, London, England, 10-13 October 2018, Vol. 101-B. Vol. Supple. British Editorial Society of Bone and Joint Surgery, (10.1302/1358-992X.2019.5.111)
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
- Williams, R., Khan, W., Williams, H., Abbas, A., Mehta, A., Ayre, W. and Morgan-Jones, R. 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting, Estoril, Portugal, 10-12 September 2015, Vol. 97-B. Vol. SUPP_1., (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
- Ayre, W., Howell, M., Madete, J. K., Jones, D. K. and Holt, C. A. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Erthyglau
- Azizova, L., Al Dalaty, A., Brousseau, E., Birchall, J., Wilkinson, T., Sloane, A. and Nishio Ayre, W. 2024. Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science 665, article number: 160337. (10.1016/j.apsusc.2024.160337)
- Jagannathan, C., Waddington, R. and Nishio Ayre, W. 2024. Nanoparticle and nanotopography-induced activation of the Wnt pathway in bone regeneration. Tissue Engineering Part B: Reviews 30(2), pp. 270-283. (10.1089/ten.TEB.2023.0108)
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604, article number: 154462. (10.1016/j.apsusc.2022.154462)
- Britton, S., Lee, K., Azizova, L., Shaw, G., Nishio Ayre, W. and Mansell, J. P. 2022. Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus. Scientific Reports 12(1), article number: 16661. (10.1038/s41598-022-20310-8)
- Sadaghiani, L., Alshumrani, A. M., Gleeson, H., Nishio Ayre, W. and Sloan, A. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S., Goel, S., Kumar, V., Pearce, O., Nishio Ayre, W. and Ivanova, E. P. 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5(1), pp. 1-17. (10.1021/acsanm.1c03045)
- Larrañaga-Altuna, M. et al. 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8(2), article number: 21303. (10.1063/5.0028844)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547, article number: 149194. (10.1016/j.apsusc.2021.149194)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35(10), pp. 1235-1252. (10.1177/0885328220983797)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11, article number: 111. (10.1186/s13578-021-00580-x)
- Jiang, L., Nishio Ayre, W., Melling, G. E., Song, B., Wei, X., Sloan, A. and Chen, X. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J., Khor, C., Nishio Ayre, W., Doyle, Z. and Chadwick, E. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6(10), article number: 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al. 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23, pp. 140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J., Ayre, W. N., Sloan, A. J. and Waddington, R. J. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26(3), pp. 217-229. (10.1089/ten.teb.2019.0312)
- Melling, G., Colombo, J. S., Avery, S., Nishio Ayre, W., Evans, S. L., Waddington, R. and Sloan, A. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24(13-14), pp. 1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86(5), article number: e00871-17. (10.1128/IAI.00871-17)
- Quiney, D., Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62, pp. 64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L., Nishio Ayre, W., Khan, W. S., Mehta, A. and Morgan-Jones, R. 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32(3), pp. 953-957. (10.1016/j.arth.2016.09.010)
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53, pp. 64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
- Lee, C. P., Colombo, J. S., Nishio Ayre, W., Sloan, A. J. and Waddington, R. J. 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6, pp. 1-13. (10.1177/2041731415586318)
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
Gosodiad
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
Ymchwil
Cyllid ymchwil
2023 - Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "ExoView R200 – Nodweddu a dadansoddi'r genhedlaeth nesaf o fesiglau allgellog a nanoronynnau. £107,249. Mai 2023. Cyd-ymgeisydd.
2023 - Mae offer craidd EPSRC yn galw "Galwad Offer EPSRC 2022 - Prifysgol Caerdydd". £757,080. Ionawr 2023. Cyd-ymgeisydd.
2023 – Efrydiaeth EPSRC DTP "Arwynebau mewnblannu gwydr metalig swmp gwrthficrobaidd ac adfywiol laser swmp-gweadog". £81,924. Hydref 2023. Prif ymgeisydd.
2022 – Rhaglen Sêr Cymru – Gwobr Gwella Offer Cystadleurwydd. "Gweithgynhyrchu Hybrid Cylchlythyr (CHM) o bowdrau cynaliadwy ar gyfer prosesau gweithgynhyrchu ychwanegion ymlediad gwely powdr (AM) trwy ailgylchu sgrapiau peiriannu". £54,136. Ionawr 2023. Cyd-ymgeisydd.
2022 - Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Peiriant gweithgynhyrchu ychwanegion golchi rhwymwr metel". £350,400. Mai 2022. Cyd-ymgeisydd
2022 – BBSRC Datblygu technolegau sylfaenol wrth synhwyro a delweddu. "Datblygu offeryn delweddu sbectrosgopeg nanoraddfa, sydd bron yn is-goch ar gyfer dadansoddiad mewn lleoliad, cyflym a di-label o fesiglau allgellog sengl". £226,242. Ebrill 2023. Prif ymgeisydd.
2021 – Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Sbectrosgopeg rhyngwynebau". £455,000. Ebrill 2022. Cyd-ymgeisydd
2021 – Offer Strategol EPSRC. "Microsgopeg Llu a ysgogwyd gan y llun (PiFM): Topograffeg Nanoscale a Sbectrosgopeg Dirgryniadol". £1,013,903. Ebrill 2022. Cyd-ymgeisydd.
2021 – Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "Labordy Gwydnwch a Chymeriadu". £383,000. Medi 2021. Cyd-ymgeisydd
2021 – GlaxoSmithKline "Gwerthusiad cymharol o effeithiolrwydd past dannedd/brwsio mewn system fodel berthnasol". £29,788. Gorffennaf 2021. Cyd-ymgeisydd
2020 – Gwobr Ymchwilydd Newydd EPSRC. "Manteisio ar ffyrnigrwydd bacteriol i sbarduno rhyddhau gwrthficrobaidd o fewnblaniadau orthopedig". £264,217. Ebrill 2021. Prif ymgeisydd.
2019 – Offer Sefydliadol EPSRC ECR. "Cysylltwch ag ongl goniometer a microbalans grisial cwarts". £48,000. Ionawr 2019. Prif ymgeisydd.
2018 – Yn erbyn Arthritis PhD Studenthip. "Technoleg mewnblannu titaniwm gwrthfacterol newydd ar gyfer cyfanswm arthroplasti ar y cyd". £111,085. Ionawr 2019. Cyd-ymgeisydd.
2018 – Ymddiriedolaeth Wellcome ISSF3 - "Arwynebau mewnblannu mewnblaniad laser-sintered gwrthficrobaidd ac osteogenig newydd gan ddefnyddio laser ultra byr-pwls ablated micro / nano-topograffïau". £49,933. Ebrill 2018. Prif ymgeisydd.
2017 – MRC Hyder mewn Cysyniad- "Gorchudd lipid cadarn a facile i wella iro a lleihau ffurfiant bioffilm ar cathetrau wrinol". £62,427. Awst 2017. Prif ymgeisydd.
2017 – Cronfa Seilwaith Ymchwil Prifysgol Caerdydd "System Sintering Plasma Spark (SPS)". £179,000. Ebrill 2017. Cyd-ymgeisydd
2016 – CYNNIG OFFER R&D Y GIG "ARGRAFFYDD 3D". £8,000 Chwefror 2016. Prif ymgeisydd.
2016 – Cronfa Bontio Gwyddorau Bywyd "Optimeiddio a phrofi gwenwyndra o'r system cyflenwi cyffuriau liposomaidd ar gyfer sment esgyrn orthopedig". £71,114. Ionawr 2017. Prif ymgeisydd.
2016 – Wellcome Trust ISSF "Gwella priodweddau gwisgo cwpanau acetabular CRF-PEEK a UHMWPE gan ddefnyddio swyddogaeth arwyneb dwylayer lipid newydd." £23,067 Gorffennaf 2016. Prif ymgeisydd.
2016 – CYNNIG OFFER R&D Y GIG "ANWEDDYDD Rotari". £5,738 Chwefror 2017. Prif ymgeisydd.
2015 – Ymddiriedolaeth Feddygol Dunhill – "Atal llacio aseptig o amnewidiadau sment ar y cyd mewn oedolion hŷn: cyflwyno moleciwlau osteogenig o sment esgyrn PMMA i annog atgyweirio esgyrn ac osseointegration mewnblannu". £86,104 Chwefror 2015 – Awst 2016. Cyd-ymgeisydd.
2015 – NIHR i4i – "Biofunctionalization fflworophosphonate o fioddeunyddiau ar gyfer ceisiadau orthopedig". £372,480 Medi 2015 – Awst 2017. Cyd-ymgeisydd.
2015 – Cynllun Agosrwydd at Ddarganfod MRC – "Sgaffaldiau dannedd dannedd biomimetig, gwrthficrobaidd a bioactif newydd ar gyfer therapïau mwydion hanfodol". £20,000 Hydref 2015 – Rhagfyr 2015. Prif ymgeisydd.
2014 – Efrydiaeth PhD Renishaw – "Gludiad bacteriol ac ataliad mewn mewnblaniad deintyddol ac arwynebau abutment". £50,000 Hydref 2015 – 2018. Cyd-ymgeisydd.
2014 – Prosiect Ymchwil Rhwydwaith Gwyddorau Bywyd Cymru – "Cyflwyno moleciwlau osteogenig o sment esgyrn acrylig i annog atgyweiriad asgwrn atgynhyrchiol o amgylch amnewidiadau ar y cyd wedi'u smentio". £49,929 Chwefror 2015 – 2016. Prif ymgeisydd.
2014 – Cynllun Her Technoleg Iechyd SARTRE – "System gyflenwi gwrthficrobaidd liposomal ar gyfer sment esgyrn PMMA". £19,635 Gorffennaf - Medi 2014. Prif ymgeisydd.
Patentau
- Denyer S, Evans S, Ayre W. System cyflenwi cyffuriau liposomaidd ar gyfer sment esgyrn. Rhif patent rhyngwladol: WO 2015004450 A1.
Mynediad i gyfleusterau
- Profion mecanyddol a blinder (Lloyd LR10K, LRX, LFPlus, Mitutoyo MVK-G1 profwr caledwch)
- Rheoleg (Bohlin C-VOR200, Cole-Parmer viscometer)
- Profilometreg (Mitutoyo Surftest SV-2000, Taicaan XYRIS)
- Colorimetry (Konica Minolta CM-700d, Dr Lange Micro Lliw II)
- ongl cyswllt (Cahn DCA-312, Attension Theta Lite)
- Microbalans Crystal Quartz (MicroVacuum QCM-I)
- Ffurfio liposome (Buchi Rotavapor R-300, Lipex allwthiwr)
- Dadansoddiad thermol mecanyddol deinamig (Rheometric Gwyddonol DMTA Mk III)
- Argraffu 3D (Asiga Pico 2, Motionview iPrint 3D)
- FTIR (Nicolet 380 FT-IR)
- Torri sampl (Logitech AXL1 Gwelodd Annular, Bae De 650)
- qRT-PCR (QuantStudio 6)
- Microsgopeg electron sganio (Tescan VEGA SEM-XRMA)
- Microsgopeg Confocal (Leica TCS SP5)
- Microbioleg
- Diwylliant meinwe
- Histoleg
- MicroCT (Bruker Skyscan 1272 - MSKBRF, Ysgol Peirianneg)
Addysgu
Addysgu israddedig
Deintyddfa (BDS), Therapi Deintyddol a Hylendid Deintyddol (BSc) - Deunyddiau Deintyddol Blwyddyn 2
- Arweinydd Pwnc ar gyfer Biomaterials Deintyddol
- Cyflwyno darlithoedd ar biocompatibility, priodweddau materol, polymerau a meteleg.
- Arwain sesiynau ymarferol deunydd cyfansawdd a deintyddol.
- Lleoliad/asesu BDS Cynradd, BDS Canolradd ac arholiadau BDS Terfynol.
- Lleoliad/asesu posteri Blwyddyn 2, cyflwyniadau llafar a thraethodau estynedig
- Tiwtor academaidd a phersonol.
Deintyddfa (BDS) - Prosiectau Blwyddyn Olaf Blwyddyn 4/5
- Goruchwylio prosiectau mewn labordy.
- Asesu adroddiadau prosiect blwyddyn olaf.
Addysgu ôl-raddedig
Peirianneg feinwe a Meddygaeth Adfywiol (MSc)
- Cyfarwyddwr Peirianneg Meinwe a Meddygaeth Adfywiol MSc.
- Goruchwylio prosiectau myfyrwyr MSc.
- Asesu traethodau hir prosiect MSc a chyflwyniadau llafar/poster.
Bioleg Lafar (MSc)
- Cyflwyno darlithoedd ar fioleg celloedd a matrics, grymoedd biofecanyddol ac ymateb meinweoedd i fioddeunyddiau.
- Gosod/asesu cyflwyniadau llafar, traethodau estynedig a chwestiynau arholiad.
- Goruchwylio prosiectau myfyrwyr MSc.
Myfyrwyr PhD
- Goruchwylio myfyrwyr PhD ar draws yr Ysgolion Deintyddiaeth, Fferylliaeth a Gwyddorau Fferyllol a Pheirianneg.
Cymwysterau
Cymrawd yr Academi Addysg Uwch (FHEA)
Bywgraffiad
Trosolwg gyrfa
- Medi 2021 - Yn bresennol: Uwch Ddarlithydd mewn Biomaterials – Ysgol Deintyddiaeth Caerdydd.
- Medi 2016 – Awst 2021: Darlithydd mewn Biomaterials – Ysgol Deintyddiaeth Caerdydd.
- Tachwedd 2014 – Medi 2016: Cymrawd ymchwil – Ysgol Deintyddiaeth Caerdydd, Peirianneg Meinwe a Deintyddiaeth Adferol. Rhwydwaith Ymchwil Gwyddorau Bywyd Cymru: Cyflwyno moleciwlau osteogenig o sment esgyrn acrylig i annog atgyweirio esgyrn atgynhyrchiol o amgylch amnewidiadau ar y cyd wedi'u smentio.
- Medi 2014 – Tachwedd 2014: Cydymaith ymchwil – Ysgol Fferylliaeth Caerdydd a'r Gwyddorau Fferyllol. Prosiect Peilot Bio-E SATRTE: Titaniwm sy'n swyddogaethol asid lysophosphatidic wedi'i deipio ffosffonate: gorffeniad wyneb newydd ar gyfer cymwysiadau adfywiol esgyrn.
- Mehefin 2014 – Awst 2014: Cyswllt ymchwil – Ysgol Fferylliaeth a Gwyddorau Fferyllol Caerdydd. Prosiect Peilot Her Technoleg Iechyd SATRTE: System gyflenwi gwrthficrobaidd liposomal ar gyfer sment esgyrn PMMA
- Rhagfyr 2013 – Mai 2014: Cydymaith ymchwil – Ysgol Deintyddiaeth, Peirianneg Meinwe a Deintyddiaeth Atgyweiriol. Ymddiriedolaeth Feddygol Dunhill: Atal poen deintyddol, crawniadau a cholli dannedd mewn oedolion hŷn: datblygu deunyddiau adferol gwrthficrobaidd i reoli clefyd deintyddol mewn oedolion hŷn
- Medi 2013 – Tachwedd 2013: Cynorthwy-ydd Ymchwil – Ysgol Peirianneg Caerdydd, Sefydliad Peirianneg Fecanyddol a Gweithgynhyrchu. Comisiwn Sky / UE Glân: Datblygu, gweithgynhyrchu a phrofi deunyddiau cyfansawdd ar gyfer cymwysiadau awyrofod.
Addysg a chymhwyster
- 2009 – 2013: Doethur mewn Athroniaeth (PhD) mewn Peirianneg Fecanyddol, Prifysgol Caerdydd/Arthritis Research UK Biomechanics and Bioengineering Centre. Prosiect ymchwil rhyngddisgyblaethol rhwng ysgolion Peirianneg a Fferylliaeth, gan ddatblygu a phrofi fformwleiddiadau newydd o sment esgyrn PMMA i wella priodweddau mecanyddol, cyffuriau ac osseointegrative.
- 2006 – 2009: Baglor Peirianneg (B.Eng. Dosbarth Cyntaf Anrh) mewn Peirianneg Feddygol, Ysgol Peirianneg, Prifysgol Caerdydd
Anrhydeddau a dyfarniadau
- 2017 - Crucible Cymru - Rhaglen Arweinwyr Ymchwil Cymru y Dyfodol
- 2016 – Cymdeithas Ymchwil Orthopedig Prydain – Cymrodoriaeth Teithio Rhyngwladol
- 2015 – Rhwydwaith Ymchwil Gwyddorau Bywyd Cymru: 2il Gyngres Darganfod Cyffuriau – Cyflwyniad Ôl-ddoethurol Gorau
- 2015 – Gwobr Ymchwilydd Ifanc Sefydliad y Meinwe a Thrwsio
- 2014 – Gwobr IADR-PER GSK-MINERALISED TISSUE GROUP.
- 2014 – Gwobr Anrhydeddus Cwmni Peirianwyr Mercia mewn Peirianneg Feddygol.
- 2014 – Bwrsariaeth Teithio Sefydliad Meinweoedd a Pheirianneg Meinweoedd Caerdydd.
- 2013 – Gwobr Poster Academy of Pharmaceutical Sciences (PharmSci) a noddir gan GlaxoSmithKline (GSK).
- 2010 a 2013 – Gwobr Teithio William Norman Thomas Sefydliad Peirianneg De Cymru (SWIEET).
- 2006 – Gwobr Prosiect 3edd flwyddyn y Sefydliad Peirianneg Fecanyddol (IMechE).
- 2006 – Gwobr Ysgol Beirianneg Caerdydd Ysgol MMM School.
Aelodaethau proffesiynol
- Aelod o'r Gymdeithas Ryngwladol ar gyfer Ymchwil Ddeintyddol/Cymdeithas Brydeinig ar gyfer Ymchwil Llafar a Deintyddol.
- Aelod o Gymdeithas Ymchwil Orthopedig Prydain.
- Aelod o Sefydliad Peirianneg ac Atgyweirio Meinwe Caerdydd.
Pwyllgorau ac adolygu
- Golygydd Arbenigol ar gyfer Ymchwil Esgyrn a Chydweithredol
- Adolygydd Meddygaeth Ddeintyddol Frontiers a Frontiers Technoleg Meddygol
- Adolygydd grant ar gyfer EPSRC/BBSRC/MRC
- Pwyllgor Gwaith Peirianneg a Thrwsio Meinwe Caerdydd
- Gweithredwr Rhwydwaith Ymchwil Deunyddiau Caerdydd
- Biomecaneg a'r Ganolfan Biobeirianneg yn erbyn Pwyllgor Gweithredol Arthritis
- Arweinydd Gyrfaoedd a Chyflogadwyedd yr Ysgol Deintyddiaeth
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PhD ym meysydd:
- Modelau in vitro o'r ymateb imiwnedd gwesteiwr i fiomaterials
- Cyflwyno gwrthficrobaidd liposomaidd i atal a thrin clefydau heintus
- Cyflwyno ffactor twf liposomaidd i annog osteogenesis
- Haenau mewnblaniad lipid gwrthficrobaidd seiliedig ar lipid
- Topograffïau mewnblaniad osteogenig a gwrthficrobaidd
- Cyflwyno cyffuriau o sment asgwrn PMMA
Cyfleoedd PhD cyfredol:
- Datblygu model in vitro o'r ymateb imiwnedd gwesteiwr i fiomaterials
- Gwneud esgyrn wedi torri yn wrthficrobaidd: Atal osteomyelitis gan ddefnyddio system gyflenwi liposomaidd wedi'i thargedu a'i fwynhau
- Laser newydd ablated arwynebau mewnblannu micro / nano ar gyfer cyflwyno therapiwteg gwrthficrobaidd ac osteogenig
- Datblygu fformwleiddiadau liposomaidd i oresgyn mecanweithiau ymwrthedd gwrthfiotig
Goruchwyliaeth gyfredol
Prosiectau'r gorffennol
Myfyrwyr PhD
- Savannah Britton - technoleg mewnblannu titaniwm gwrthfacterol newydd ar gyfer cyfanswm arthroplasti ar y cyd (parhaus)
- Peter Hansal - Optimeiddio a gwella system gyflenwi liposomaidd (gwobrwywyd 2022)
- Clotilde Haury - Ymlyniad pathogenau peri-mewnblannu i ategion toddi laser a datblygu cotio gwrthficrobaidd newydd (gwobrwywyd 2019)
- Madhan Natarajan - Nodweddu ymatebion mwydion i her bacteriol a gwrthficroborau newydd ar gyfer rheoli halogiad bacteriol o fwydion heintiedig (gwobrwywyd 2018)
Myfyrwyr MSc
- Yimin Ge - Effaith phosphatidylserine, phosphatidylethalonamine a liposomau phosphatidylcholine ar wahaniaethu osteogenig celloedd strêr esgyrn dynol (gwobrwywyd 2023)
- Gisselle Montenegro - mynegiant derbynnydd Phosphatidylserine, lleoleiddio ac actifadu mewn celloedd strêr mêr esgyrn dynol (gwobrwywyd 2022)
- Thomas Green - Modiwleiddio'r ymateb gwesteiwr i fewnblaniadau orthopedig gan ddefnyddio laser pwls ultra-fer blated micro/nano-topograffïau (gwobrwywyd 2022)
- James Adams - Gwrthweithyddion derbynyddion glwtamad ar gyfer trin clefyd periodontal (gwobrwywyd 2022)
- Marella Cuevas - mynegiant derbynnydd Phosphatidylserine, lleoleiddio ac actifadu mewn celloedd MG-63 wedi'u trin â liposomau (gwobrwywyd 2021)
- Sarah Jefferies - Gwrthweithyddion derbynnydd glwtamad ar gyfer trin clefyd periodontal (gwobrwywyd 2021)
- Chitra Jagannathan - actifadu Nanoparticle a nanotopograffi ar lwybr signalau Wnt wrth adfywio esgyrn: Adolygiad o'r llenyddiaeth (gwobrwywyd 2020)
- Lujien Dribika - Cyflwyno liposomaidd o ffactorau twf ar gyfer atgyweirio meinwe mwynol gwell (gwobrwywyd 2020)
- Rawan Abu Dagga - Swyddogaethau biolegol a mecanweithiau gweithredu phosphatidylserine mewn atgyweirio esgyrn (dyfarnwyd 2020)
- Yumeng Guo - Modelau in vitro i astudio'r ymateb imiwnedd gwesteiwr i heintiau bioddeunydd (dyfarnwyd 2020)
- Abdullah Alshumrani - Ymddygiad celloedd progenitor mwydion deintyddol wedi'u diwyllo ar arwynebau dentin cyflyredig (gwobrwywyd 2019)
- Liam O'Brien - Eludicating mecanweithiau gweithredu gwrth-lynol cotio mewnblaniad orthopedig FHBP yn erbyn ynysigau clinigol Staphylococcus aureus (gwobrwywyd 2019)
- Maria Suarez Arocena - Ymateb mwydion deintyddol i hydrogen perocsid a'i botensial wrth drin caris deintyddol (gwobrwywyd 2018)
- Yingke Cai - Gwrthweithyddion cludwr glutamad ar gyfer trin clefyd periodontal (gwobrwywyd 2018)
- Ana Springall de Pablo - Datblygu model ar y cyd ex vivo i astudio heintiau prosthetig sy'n gysylltiedig â bioffilm (gwobrwywyd 2017)
- Miles Thompson - Effaith zoledronate liposomal ar bolareiddio macrophage a phagocytosis haint sy'n gysylltiedig â mewnblaniad Staphylococcus aureus (gwobrwywyd 2017)
- Rebecca Beamish - Cyflwyno gwrthfiotigau o sment esgyrn liposomal ostegenig (gwobrwywyd 2016)
Contact Details
AyreWN@caerdydd.ac.uk
+44 29225 10660
Ysbyty Deintyddol y Brifysgol, Ystafell 5F.06 Swyddfa Ymchwil Ôl-raddedig, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
+44 29225 10660
Ysbyty Deintyddol y Brifysgol, Ystafell 5F.06 Swyddfa Ymchwil Ôl-raddedig, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
Themâu ymchwil
Arbenigeddau
- Biomaterialau
- Orthopedeg
- Cyflwyno cyffuriau
- Topograffïau mewnblannu
- Lipids