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Dr Wayne Nishio
(he/him)
BEng (Hons) PhD FHEA
- Available for postgraduate supervision
Teams and roles for Wayne Nishio
Senior Lecturer in Biomaterials
Overview
My ambition is to become an established academic in the field of biomaterials, by delivering high impact research and teaching excellence. I am the lead for the Biomaterials Research Group at the School of Dentistry, Cardiff University and director of the Tissue Engineering and Regenerative Medicine MSc programme. My research interests include: the design, development and testing of medical devices and biomaterials; adopting an inter-disciplinary approach to research through academic and industrial scientific collaborations; understanding and improving drug delivery and antimicrobial aspects of biomaterials; and understanding and enhancing the interactions between medical devices, tissues and cells. My particular areas of interest revolve around using lipid coatings and delivery systems to enhance osseointegration and prevent infections of orthopaedic and dental materials.
Expertise
- Drug delivery from biomaterials
- Liposomal delivery systems
- Orthopaedic and dental implant coatings and topographies
- Prince2 Agile Project Management: Foundation and Practitioner
Publication
2024
- Green, T., Nishio, W., Bigot, S., Brousseau, E. and Bhaduri, D. 2024. Laser surface texturing of bulk metallic glass for orthopaedic application. Presented at: School of Engineering Research Conference 2024, Cardiff, UK, 12-14 June 2024 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardiff University School of Engineering Research Conference 2024.. Cardiff, Wales: Cardiff University Press, (10.18573/conf3.b)
- Azizova, L., Al Dalaty, A., Brousseau, E., Birchall, J., Wilkinson, T., Sloane, A. and Nishio Ayre, W. 2024. Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science 665, article number: 160337. (10.1016/j.apsusc.2024.160337)
- Jagannathan, C., Waddington, R. and Nishio Ayre, W. 2024. Nanoparticle and nanotopography-induced activation of the Wnt pathway in bone regeneration. Tissue Engineering Part B: Reviews 30(2), pp. 270-283. (10.1089/ten.TEB.2023.0108)
2022
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604, article number: 154462. (10.1016/j.apsusc.2022.154462)
- Britton, S., Lee, K., Azizova, L., Shaw, G., Nishio Ayre, W. and Mansell, J. P. 2022. Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus. Scientific Reports 12(1), article number: 16661. (10.1038/s41598-022-20310-8)
- Sadaghiani, L., Alshumrani, A. M., Gleeson, H., Nishio Ayre, W. and Sloan, A. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S., Goel, S., Kumar, V., Pearce, O., Nishio Ayre, W. and Ivanova, E. P. 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5(1), pp. 1-17. (10.1021/acsanm.1c03045)
- Mason, B., Ryan, M., Setchi, R., Kundu, A., Nishio Ayre, W. and Bhaduri, D. 2022. Development of a novel laser polishing strategy for additively manufactured AlSi10Mg alloy parts. Presented at: 9th International Conference on Sustainable Design and Manufacturing - SDM 2022, Split, Croatia, 16-17 September 2022.
2021
- Larrañaga-Altuna, M. et al. 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8(2), article number: 21303. (10.1063/5.0028844)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547, article number: 149194. (10.1016/j.apsusc.2021.149194)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35(10), pp. 1235-1252. (10.1177/0885328220983797)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11, article number: 111. (10.1186/s13578-021-00580-x)
2020
- Jiang, L., Nishio Ayre, W., Melling, G. E., Song, B., Wei, X., Sloan, A. and Chen, X. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J., Khor, C., Nishio Ayre, W., Doyle, Z. and Chadwick, E. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6(10), article number: 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al. 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23, pp. 140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J., Ayre, W. N., Sloan, A. J. and Waddington, R. J. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26(3), pp. 217-229. (10.1089/ten.teb.2019.0312)
2019
- Beamish, R., Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress, London, England, 10-13 October 2018, Vol. 101-B. Vol. Supple. British Editorial Society of Bone and Joint Surgery, (10.1302/1358-992X.2019.5.111)
2018
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
- Melling, G., Colombo, J. S., Avery, S., Nishio Ayre, W., Evans, S. L., Waddington, R. and Sloan, A. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24(13-14), pp. 1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86(5), article number: e00871-17. (10.1128/IAI.00871-17)
- Williams, R., Khan, W., Williams, H., Abbas, A., Mehta, A., Ayre, W. and Morgan-Jones, R. 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting, Estoril, Portugal, 10-12 September 2015, Vol. 97-B. Vol. SUPP_1., (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
2017
- Quiney, D., Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62, pp. 64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L., Nishio Ayre, W., Khan, W. S., Mehta, A. and Morgan-Jones, R. 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32(3), pp. 953-957. (10.1016/j.arth.2016.09.010)
2016
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Sloan, A., Colombo, J., Roberts, J., Waddington, R. and Nishio Ayre, W. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons, pp. 96-109., (10.1002/9781119282181.ch5)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53, pp. 64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
2015
- Lee, C. P., Colombo, J. S., Nishio Ayre, W., Sloan, A. J. and Waddington, R. J. 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6, pp. 1-13. (10.1177/2041731415586318)
2014
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
2013
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
2012
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
2010
- Ayre, W., Howell, M., Madete, J. K., Jones, D. K. and Holt, C. A. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Adrannau llyfrau
- Sloan, A., Colombo, J., Roberts, J., Waddington, R. and Nishio Ayre, W. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons, pp. 96-109., (10.1002/9781119282181.ch5)
Cynadleddau
- Green, T., Nishio, W., Bigot, S., Brousseau, E. and Bhaduri, D. 2024. Laser surface texturing of bulk metallic glass for orthopaedic application. Presented at: School of Engineering Research Conference 2024, Cardiff, UK, 12-14 June 2024 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardiff University School of Engineering Research Conference 2024.. Cardiff, Wales: Cardiff University Press, (10.18573/conf3.b)
- Mason, B., Ryan, M., Setchi, R., Kundu, A., Nishio Ayre, W. and Bhaduri, D. 2022. Development of a novel laser polishing strategy for additively manufactured AlSi10Mg alloy parts. Presented at: 9th International Conference on Sustainable Design and Manufacturing - SDM 2022, Split, Croatia, 16-17 September 2022.
- Beamish, R., Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress, London, England, 10-13 October 2018, Vol. 101-B. Vol. Supple. British Editorial Society of Bone and Joint Surgery, (10.1302/1358-992X.2019.5.111)
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
- Williams, R., Khan, W., Williams, H., Abbas, A., Mehta, A., Ayre, W. and Morgan-Jones, R. 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting, Estoril, Portugal, 10-12 September 2015, Vol. 97-B. Vol. SUPP_1., (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
- Ayre, W., Howell, M., Madete, J. K., Jones, D. K. and Holt, C. A. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Erthyglau
- Azizova, L., Al Dalaty, A., Brousseau, E., Birchall, J., Wilkinson, T., Sloane, A. and Nishio Ayre, W. 2024. Antimicrobial release from a lipid bilayer titanium implant coating is triggered by Staphylococcus aureus alpha-haemolysin. Applied Surface Science 665, article number: 160337. (10.1016/j.apsusc.2024.160337)
- Jagannathan, C., Waddington, R. and Nishio Ayre, W. 2024. Nanoparticle and nanotopography-induced activation of the Wnt pathway in bone regeneration. Tissue Engineering Part B: Reviews 30(2), pp. 270-283. (10.1089/ten.TEB.2023.0108)
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604, article number: 154462. (10.1016/j.apsusc.2022.154462)
- Britton, S., Lee, K., Azizova, L., Shaw, G., Nishio Ayre, W. and Mansell, J. P. 2022. Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus. Scientific Reports 12(1), article number: 16661. (10.1038/s41598-022-20310-8)
- Sadaghiani, L., Alshumrani, A. M., Gleeson, H., Nishio Ayre, W. and Sloan, A. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S., Goel, S., Kumar, V., Pearce, O., Nishio Ayre, W. and Ivanova, E. P. 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5(1), pp. 1-17. (10.1021/acsanm.1c03045)
- Larrañaga-Altuna, M. et al. 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8(2), article number: 21303. (10.1063/5.0028844)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547, article number: 149194. (10.1016/j.apsusc.2021.149194)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35(10), pp. 1235-1252. (10.1177/0885328220983797)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11, article number: 111. (10.1186/s13578-021-00580-x)
- Jiang, L., Nishio Ayre, W., Melling, G. E., Song, B., Wei, X., Sloan, A. and Chen, X. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J., Khor, C., Nishio Ayre, W., Doyle, Z. and Chadwick, E. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6(10), article number: 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al. 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23, pp. 140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J., Ayre, W. N., Sloan, A. J. and Waddington, R. J. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26(3), pp. 217-229. (10.1089/ten.teb.2019.0312)
- Melling, G., Colombo, J. S., Avery, S., Nishio Ayre, W., Evans, S. L., Waddington, R. and Sloan, A. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24(13-14), pp. 1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86(5), article number: e00871-17. (10.1128/IAI.00871-17)
- Quiney, D., Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62, pp. 64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L., Nishio Ayre, W., Khan, W. S., Mehta, A. and Morgan-Jones, R. 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32(3), pp. 953-957. (10.1016/j.arth.2016.09.010)
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53, pp. 64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
- Lee, C. P., Colombo, J. S., Nishio Ayre, W., Sloan, A. J. and Waddington, R. J. 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6, pp. 1-13. (10.1177/2041731415586318)
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
Gosodiad
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
Research
Research funding
2023 - Cardiff University Research Infrastructure Fund “ExoView R200 – Next-generation characterization and analysis of extracellular vesicles and nanoparticles. £107,249. May 2023. Co-applicant.
2023 - EPSRC Core Equipment Call "EPSRC Equipment Call 2022 - Cardiff University ". £757,080. January 2023. Co-applicant.
2023 – EPSRC DTP Studentship "Novel antimicrobial and regenerative laser-textured bulk metallic glass implant surfaces". £81,924. October 2023. Principal applicant.
2022 – Sêr Cymru programme – Enhancing Competitiveness Equipment Award. "Circular Hybrid Manufacturing (CHM) of sustainable powders for powder-bed-fusion additive manufacturing (AM) processes via recycling of machining scraps". £54,136. January 2023. Co-applicant.
2022 - Cardiff University Research Infrastructure Fund “A metal binder jetting additive manufacturing machine”. £350,400. May 2022. Co-applicant
2022 – BBSRC Develop basic technologies in sensing and imaging. "Development of a nanoscale, near-infrared spectroscopy imaging tool for in situ, rapid and label-free analysis of single extracellular vesicles". £226,242. April 2023. Principal applicant.
2021 – Cardiff University Research Infrastructure Fund “Spectroscopy of interfaces”. £455,000. April 2022. Co-applicant
2021 – EPSRC Strategic Equipment. "Photo induced Force Microscopy (PiFM): Nanoscale Topography and Vibrational Spectroscopy". £1,013,903. April 2022. Co-applicant.
2021 – Cardiff University Research Infrastructure Fund “Durability and Characterisation Laboratory”. £383,000. September 2021. Co-applicant
2021 – GlaxoSmithKline. "Comparative evaluation of toothpaste/brushing efficacy in a relevant model system". £29,788. July 2021. Co-Applicant
2020 – EPSRC New Investigator Award. “Exploiting bacterial virulence to trigger antimicrobial release from orthopaedic implants”. £264,217. April 2021. Principal applicant.
2019 – EPSRC ECR Institutional Equipment. “Contact angle goniometer and quartz crystal microbalance”. £48,000. January 2019. Principal applicant.
2018 – Versus Arthritis PhD Studentship. “A novel antibacterial titanium implant technology for total joint arthroplasty”. £111,085. January 2019. Co-applicant.
2018 – Wellcome Trust ISSF3 – “Novel antimicrobial and osteogenic laser-sintered implant surfaces using ultra short-pulsed laser ablated micro/nano-topographies”. £49,933. April 2018. Principal applicant.
2017 – MRC Confidence in Concept- “Robust and facile lipid coating to enhance lubrication and reduce biofilm formation on urinary catheters”. £62,427. August 2017. Principal applicant.
2017 – Cardiff University Research Infrastructure Fund “Spark Plasma Sintering (SPS) system”. £179,000. April 2017. Co-applicant
2016 – NHS R&D Equipment bid “3D Printer”. £8,000 February 2016. Principal applicant.
2016 – Life Sciences Bridging Fund “Optimisation and toxicity testing of the liposomal drug delivery system for orthopaedic bone cement”. £71,114. January 2017. Principal applicant.
2016 – Wellcome Trust ISSF “Enhancing wear properties of CRF-PEEK and UHMWPE acetabular cups using a novel lipid bilayer surface functionalization.” £23,067 July 2016. Principal applicant.
2016 – NHS R&D Equipment bid “Rotary evaporator”. £5,738 February 2017. Principal applicant.
2015 – Dunhill Medical Trust – “Preventing aseptic loosening of cemented joint replacements in older adults: delivery of osteogenic molecules from PMMA bone cement to encourage bone repair and implant osseointegration”. £86,104 February 2015 – August 2016. Co-applicant.
2015 – NIHR i4i – “Fluorophosphonate biofunctionalisation of biomaterials for orthopaedic applications”. £372,480 September 2015 – August 2017. Co-applicant.
2015 – MRC Proximity to Discover Scheme – “Novel biomimetic, antimicrobial and bioactive dentine scaffolds for vital pulp therapies”. £20,000 October 2015 – December 2015. Principal applicant.
2014 – Renishaw PhD Studentship – “Bacterial adhesion and inhibition at dental implant and abutment surfaces”. £50,000 October 2015 – 2018. Co-applicant.
2014 – Life Sciences Research Network Wales Research Project – “Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements”. £49,929 February 2015 – 2016. Principal applicant.
2014 – SARTRE Health Technology Challenge Scheme – “Liposomal antimicrobial delivery system for PMMA bone cement”. £19,635 July – September 2014. Principal applicant.
Patents
- Denyer S, Evans S, Ayre W. Liposomal drug delivery system for bone cements. International Patent number: WO 2015004450 A1.
Access to facilities
- Mechanical and fatigue testing (Lloyd LR10K, LRX, LFPlus, Mitutoyo MVK-G1 hardness tester)
- Rheology (Bohlin C-VOR200, Cole-Parmer rotational viscometer)
- Profilometry (Mitutoyo Surftest SV-2000, Taicaan XYRIS)
- Colorimetry (Konica Minolta CM-700d, Dr Lange Micro Color II)
- Contact angle (Cahn DCA-312, Attension Theta Lite)
- Quartz Crystal Microbalance (MicroVacuum QCM-I)
- Liposome formulation (Buchi Rotavapor R-300, Lipex Extruder)
- Dynamic mechanical thermal analysis (Rheometric Scientific DMTA Mk III)
- 3D printing (Asiga Pico 2, Motionview iPrint 3D)
- FTIR (Nicolet 380 FT-IR)
- Sample cutting (Logitech AXL1 Annular Saw, South Bay 650)
- qRT-PCR (QuantStudio 6)
- Scanning electron microscopy (Tescan VEGA SEM-XRMA)
- Confocal microscopy (Leica TCS SP5)
- Microbiology
- Tissue culture
- Histology
- MicroCT (Bruker Skyscan 1272 - MSKBRF, School of Engineering)
Teaching
Undergraduate teaching
Dental Surgery (BDS), Dental Therapy and Dental Hygiene (BSc) - Year 2 Dental Materials
- Topic lead for Dental Biomaterials
- Deliver lectures on biocompatibility, material properties, polymers and metallurgy.
- Lead on composite and dental material practical sessions.
- Setting/assessing Primary BDS, Intermediate BDS and Final BDS examinations.
- Setting/assessing Year 2 posters, oral presentations and extended essays
- Academic and personal tutor.
Dental Surgery (BDS) - Year 4/5 Final Year Projects
- Supervision of laboratory-based projects.
- Assessing final year project reports.
Postgraduate teaching
Tissue Engineering and Regenerative Medicine (MSc)
- Director of Tissue Engineering and Regenerative Medicine MSc.
- Supervision of MSc student projects.
- Assessing MSc project dissertations and oral/poster presentations.
Oral Biology (MSc)
- Deliver lectures on cell and matrix biology, biomechanical forces and response of tissues to biomaterials.
- Setting/assessing oral presentations, extended essays and exam questions.
- Supervision of MSc student projects.
PhD Students
- Supervision of PhD students across the Schools of Dentistry, Pharmacy and Pharmaceutical Sciences and Engineering.
Qualifications
Fellow of the Higher Education Academy (FHEA)
Biography
Career overview
- September 2021 - Present: Senior Lecturer in Biomaterials – Cardiff School of Dentistry.
- September 2016 – August 2021: Lecturer in Biomaterials – Cardiff School of Dentistry.
- November 2014 – September 2016: Research fellow – Cardiff School of Dentistry, Tissue Engineering & Reparative Dentistry. Life Sciences Research Network Wales: Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements.
- September 2014 – November 2014: Research associate – Cardiff School of Pharmacy and Pharmaceutical Sciences. SATRTE Bio-E Pilot Project: Phosphonate-tethered lysophosphatidic acid-functionalised titanium: a novel surface finish for bone regenerative applications.
- June 2014 – August 2014: Research associate – Cardiff School of Pharmacy and Pharmaceutical Sciences. SATRTE Health Technology Challenge Pilot Project: Liposomal antimicrobial delivery system for PMMA bone cement
- December 2013 – May 2014: Research associate – Cardiff School of Dentistry, Tissue Engineering & Reparative Dentistry. Dunhill Medical Trust: Preventing dental pain, abscess and tooth loss in older adults: development of antimicrobial restorative materials to manage dental disease in older adults
- September 2013 – November 2013: Research assistant – Cardiff School of Engineering, Institute of Mechanical and Manufacturing Engineering. Clean Sky/EU Commission: Developing, manufacturing and testing composite materials for aerospace applications.
Education and qualification
- 2009 – 2013: Doctor of Philosophy (Ph.D.) in Mechanical Engineering, Cardiff University/Arthritis Research UK Biomechanics and Bioengineering Centre. Inter-disciplinary research project between the schools of Engineering and Pharmacy, developing and testing novel formulations of PMMA bone cements to enhance mechanical, drug delivery and osseointegrative properties.
- 2006 – 2009: Bachelor of Engineering (B.Eng. First Class Hons) in Medical Engineering, School of Engineering, Cardiff University
Honours and awards
- 2017 - Welsh Crucible - Future Research Leaders of Wales Programme
- 2016 – British Orthopaedic Research Society – International Travelling Fellowship
- 2015 – Life Sciences Research Network Wales: 2nd Drug Discovery Congress – Best Post-doctoral presentation
- 2015 – Cardiff Institute of Tissue Engineering and Repair Young Investigator Award
- 2014 – IADR-PER GSK-Mineralised tissue group prize.
- 2014 – The Worshipful Company of Engineers Mercia Award in Medical Engineering.
- 2014 – Cardiff Institute of Tissue Engineering and Repair Travel Bursary.
- 2013 – Academy of Pharmaceutical Sciences (PharmSci) Poster Award sponsored by GlaxoSmithKline (GSK).
- 2010 & 2013 – South Wales Institute of Engineering Educational Trust (SWIEET) William Norman Thomas Travel Award.
- 2006 – Institute of Mechanical Engineering (IMechE) 3rd Year Project Prize.
- 2006 – Cardiff School of Engineering MMM School Prize.
Professional memberships
- Member of the International Association for Dental Research/British Society for Oral and Dental Research.
- Member of British Orthopaedics Research Society.
- Member of the Cardiff Institute of Tissue Engineering and Repair.
Committees and reviewing
- Specialty Editor for Bone and Joint Research
- Reviewer for Frontiers Dental Medicine and Frontiers Medical Technology
- Grant reviewer for EPSRC/BBSRC/MRC
- Cardiff Institute of Tissue Engineering and Repair Executive Committee
- Cardiff Materials Research Network Executive Commitee
- Biomechanics and Bioengineering Centre Versus Arthritis Executive Committee
- Careers and Employability lead for School of Dentistry
Supervisions
I am interested in supervising PhD students in the areas of:
- In vitro models of the host immune response to biomaterials
- Liposomal antimicrobial delivery to prevent and treat infectious diseases
- Liposomal growth factor delivery to encourage osteogenesis
- Antimicrobial lipid-based implant coatings
- Osteogenic and antimicrobial implant topographies
- Drug delivery from PMMA bone cements
Current PhD Opportunities:
- The development of an in vitro model of the host immune response to biomaterials
- Making broken bones antimicrobial: Preventing osteomyelitis using a targeted and mineralising liposomal delivery system
- Novel laser ablated micro/nano implant surfaces for the delivery of antimicrobial and osteogenic therapeutics
- Developing liposomal formulations to overcome mechanisms of antibiotic resistance
Current supervision
Past projects
PhD Students
- Savannah Britton - A novel antibacterial titanium implant technology for total joint arthroplasty (ongoing)
- Peter Hansal - Optimisation and enhancement of a liposomal delivery system (awarded 2022)
- Clotilde Haury - Attachment of peri-implant pathogens to laser melted abutments and the development of a novel antimicrobial coating (awarded 2019)
- Madhan Natarajan - Characterisation of pulpal responses to bacterial challenge and novel antimicrobails for management of bacterial contamination of infected pulps (awarded 2018)
MSc Students
- Yimin Ge - The effect of phosphatidylserine, phosphatidylethalonamine and phosphatidylcholine liposomes on the osteogenic differentiation of human bone marrow stromal cells (awarded 2023)
- Gisselle Montenegro - Phosphatidylserine receptor expression, localisation and activation in human bone marrow stromal cells (awarded 2022)
- Thomas Green - Modulating the host response to orthopaedic implants using ultra-short pulsed laser ablated micro/nano-topographies (awarded 2022)
- James Adams - Glutamate receptor antagonists for the treatment of periodontal disease (awarded 2022)
- Marella Cuevas - Phosphatidylserine receptor expression, localisation and activation in MG-63 cells treated with liposomes (awarded 2021)
- Sarah Jefferies - Glutamate receptor antagonists for the treatment of periodontal disease (awarded 2021)
- Chitra Jagannathan - Nanoparticle and nanotopography-induced activation of the Wnt signalling pathway in bone regeneration: A review of the literature (awarded 2020)
- Lujien Dribika - Liposomal delivery of growth factors for enhanced mineralised tissue repair (awarded 2020)
- Rawan Abu Dagga - Biological functions and mechanisms of action of phosphatidylserine in bone repair (awarded 2020)
- Yumeng Guo - In vitro models to study the host immune response to biomaterial infections (awarded 2020)
- Abdullah Alshumrani - The behaviour of dental pulp progenitor cells cultured on conditioned dentine surfaces (awarded 2019)
- Liam O'Brien - Eludicating the anti-adherent mechanisms of action of an FHBP orthopaedic implant coating against clinical isolates of Staphylococcus aureus (awarded 2019)
- Maria Suarez Arocena - Dental pulp response to hydrogen peroxide and its potential in the treatment of dental caries (awarded 2018)
- Yingke Cai - Glutamate transporter antagonists for the treatment of periodontal disease (awarded 2018)
- Ana Springall de Pablo - Development of an ex vivo joint model to study biofilm-related prosthetic infections (awarded 2017)
- Miles Thompson - The effect of liposomal zoledronate on macrophage polarisation and phagocytosis of Staphylococcus aureus implant-related infection (awarded 2017)
- Rebecca Beamish - Delivery of antibiotics from osteogenic liposomal bone cement (awarded 2016)
Contact Details
AyreWN@cardiff.ac.uk
+44 29225 10660
University Dental Hospital, Room 5F.06 Postgraduate Research Office, Heath Park, Cardiff, CF14 4XY
+44 29225 10660
University Dental Hospital, Room 5F.06 Postgraduate Research Office, Heath Park, Cardiff, CF14 4XY
Research themes
Specialisms
- Biomaterials
- Orthopaedics
- Drug delivery
- Implant topographies
- Lipids