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Mr Ian Boostrom
Timau a rolau for Ian Boostrom
Rheolwr Labordy, Ymchwil Microbioleg Meddygol
Trosolwyg
Rwy'n Rheolwr Labordy yn yr Ysgol Feddygaeth sydd hefyd yn arbenigo mewn genomeg microbaidd, dilyniannu nanopore, a llifoedd gwaith labordy-i-gyfrifiadurol ar gyfer ymchwil microbioleg feddygol. Rwy'n cefnogi seilwaith labordy a rennir, caffael, contractau, hyfforddiant, ymgysylltu, cysylltu â thimau ystadau/rheoli GIG a Phrifysgol Caerdydd, a datrys problemau arbrofol ar draws amgylchedd ymchwil microbioleg feddygol prysur.
Un o themâu canolog fy ngwaith presennol yw pontio'r bwlch rhwng offer biowybodeg cymhleth ac anghenion ymarferol ymchwilwyr labordy, ymchwil cyfagos i wasanaethau, a chydweithwyr amlddisgyblaethol a ddaeth ynghyd gan yr Athro Brad Spiller. Mae gennyf ddiddordeb arbennig mewn helpu cydweithwyr i wneud defnydd effeithiol o adnoddau uwchgyfrifiadura ardderchog Prifysgol Caerdydd drwy ARCCA, gan gynnwys trwy fy nghyswllt fel aelod o Grŵp Defnyddwyr Gweithredol ARCCA.
Rwy'n gallu ymgysylltu ag ystod eang o gydweithwyr trwy dynnu ar brofiad mewn lleoliadau labordy clinigol, cyd-destunau rhyngwladol ac adnoddau isel, a gwaith sy'n cynnwys micro-organebau rheoledig, arwyddocaol yn glinigol ac uwch-gyfyngiad. Er nad yw'n berthnasol i labordai'r DU, rwyf wedi cynnal achrediad Technolegwyr Meddygol Americanaidd ers amser maith ac yn cefnogi'n gryf eu hymdrechion i alluogi llwybrau ardystio ymarferol a gwydn ar gyfer Gweithwyr Iechyd Proffesiynol Allied.
Mae fy niddordebau ehangach yn cynnwys ymwrthedd gwrthficrobaidd, microbioleg ddiagnostig (aelod ESGMD), Legionella (aelod ESGLI), genomeg pathogen, dilyniannu hir-ddarllen, arferion data FAIR ac atgynhyrchadwy (gweler Dr. Robert Andrews), hyrwyddo treialon gwydn ac effeithiol (gweler Dr. Lucy Jones), seilwaith ymchwil, a chyflwyno dulliau dilyniannu uwch yn ymarferol mewn amgylcheddau labordy a rennir. Rwyf hefyd wedi dod â diddordeb cynyddol mewn mycoleg feddygol drwy'r fraint o groesawu'r Athro Lewis White a'i dîm ymchwil ar ein llawr yn Ysbyty Athrofaol Cymru.
Cyhoeddiad
2026
- Saud, Z. et al. 2026. Discovery of a fungal Tc toxin complex and functional mycoserpin through a novel two-by-two comparative genomics approach. Frontiers in Cellular and Infection Microbiology 16 1800461. (10.3389/fcimb.2026.1800461)
2025
- Sands, K. et al. 2025. Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger. Nature Communications 16 (1) 6751. (10.1038/s41467-025-61718-w)
2024
- Nieto-Rosado, M. et al. 2024. Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria. Nature Communications 15 2758. (10.1038/s41467-024-46684-z)
- Portal, E. A. R. et al. 2024. Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria. Nature Communications 15 (1) 2302. (10.1038/s41467-024-45673-6)
2023
- Farzana, R. et al. 2023. Genomic insights into the mechanism of carbapenem resistance dissemination in Enterobacterales from a tertiary public heath setting in South Asia. Clinical Infectious Diseases 76 (1), pp.119-133. (10.1093/cid/ciac287)
2022
- Carvalho, M. J. et al., 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7 , pp.1337-1347. (10.1038/s41564-022-01184-y)
- Acolatse, J. E. E. et al., 2022. Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital. Antimicrobial Resistance and Infection Control 11 (1) 49. (10.1186/s13756-022-01090-2)
- Boostrom, I. et al. 2022. Comparing long-read assemblers to explore the potential of a sustainable low-cost, low-infrastructure approach to sequence antimicrobial resistant bacteria with Oxford nanopore sequencing. Frontiers in Microbiology 13 796465. (10.3389/fmicb.2022.796465)
2021
- Boostrom, I. et al. 2021. Evaluation of the MYCOPLASMA IST3 urogenital mycoplasma assay in an international multicentre trial. Journal of Antimicrobial Chemotherapy 76 (12), pp.3175-3182. (10.1093/jac/dkab320)
- Sharratt, M. et al. 2021. Defining fluoroquinolone resistance-mediating mutations from non-resistance polymorphisms in Mycoplasma hominis Topoisomerases. Antibiotics 10 (11) 1379. (10.3390/antibiotics10111379)
- Spiller-Boulter, O. et al., 2021. Determination of in vitro antimicrobial susceptibility for Lefamulin (Pleuromutilin) for Ureaplasma Spp. and Mycoplasma hominis. Antibiotics 10 (11) 1370. (10.3390/antibiotics10111370)
2020
- Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25 (21) 4904. (10.3390/molecules25214904)
- Farzana, R. et al. 2020. Molecular and epidemiological analysis of a Burkholderia cepacia sepsis outbreak from a tertiary care hospital in Bangladesh. PLoS Neglected Tropical Diseases 14 (4) e0008200. (10.1371/journal.pntd.0008200)
2019
- Farzana, R. et al. 2019. Emergence of mcr-1 mediated colistin resistant Escherichia coli from a hospitalized patient in Bangladesh. Journal of Infection in Developing Countries 13 (08), pp.773-776. (10.3855/jidc.11541)
Erthyglau
- Saud, Z. et al. 2026. Discovery of a fungal Tc toxin complex and functional mycoserpin through a novel two-by-two comparative genomics approach. Frontiers in Cellular and Infection Microbiology 16 1800461. (10.3389/fcimb.2026.1800461)
- Sands, K. et al. 2025. Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger. Nature Communications 16 (1) 6751. (10.1038/s41467-025-61718-w)
- Nieto-Rosado, M. et al. 2024. Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria. Nature Communications 15 2758. (10.1038/s41467-024-46684-z)
- Portal, E. A. R. et al. 2024. Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria. Nature Communications 15 (1) 2302. (10.1038/s41467-024-45673-6)
- Farzana, R. et al. 2023. Genomic insights into the mechanism of carbapenem resistance dissemination in Enterobacterales from a tertiary public heath setting in South Asia. Clinical Infectious Diseases 76 (1), pp.119-133. (10.1093/cid/ciac287)
- Carvalho, M. J. et al., 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7 , pp.1337-1347. (10.1038/s41564-022-01184-y)
- Acolatse, J. E. E. et al., 2022. Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital. Antimicrobial Resistance and Infection Control 11 (1) 49. (10.1186/s13756-022-01090-2)
- Boostrom, I. et al. 2022. Comparing long-read assemblers to explore the potential of a sustainable low-cost, low-infrastructure approach to sequence antimicrobial resistant bacteria with Oxford nanopore sequencing. Frontiers in Microbiology 13 796465. (10.3389/fmicb.2022.796465)
- Boostrom, I. et al. 2021. Evaluation of the MYCOPLASMA IST3 urogenital mycoplasma assay in an international multicentre trial. Journal of Antimicrobial Chemotherapy 76 (12), pp.3175-3182. (10.1093/jac/dkab320)
- Sharratt, M. et al. 2021. Defining fluoroquinolone resistance-mediating mutations from non-resistance polymorphisms in Mycoplasma hominis Topoisomerases. Antibiotics 10 (11) 1379. (10.3390/antibiotics10111379)
- Spiller-Boulter, O. et al., 2021. Determination of in vitro antimicrobial susceptibility for Lefamulin (Pleuromutilin) for Ureaplasma Spp. and Mycoplasma hominis. Antibiotics 10 (11) 1370. (10.3390/antibiotics10111370)
- Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25 (21) 4904. (10.3390/molecules25214904)
- Farzana, R. et al. 2020. Molecular and epidemiological analysis of a Burkholderia cepacia sepsis outbreak from a tertiary care hospital in Bangladesh. PLoS Neglected Tropical Diseases 14 (4) e0008200. (10.1371/journal.pntd.0008200)
- Farzana, R. et al. 2019. Emergence of mcr-1 mediated colistin resistant Escherichia coli from a hospitalized patient in Bangladesh. Journal of Infection in Developing Countries 13 (08), pp.773-776. (10.3855/jidc.11541)