Ewch i’r prif gynnwys
Jeremy Guggenheim

Dr Jeremy Guggenheim


Yr Ysgol Optometreg a Gwyddorau'r Golwg

Ar gael fel goruchwyliwr ôl-raddedig


Research Overview

My research is aimed at discovering the causes of short-sightedness (myopia). Approximately 1 in 3 people in the United Kingdom suffer from myopia, and the condition increases the risk of a number of serious eye disorders. I have contributed to collaborative efforts with researchers from across the world, leading to the discovery of more than a hundred genetic variants that increase susceptibility to myopia. Nobody yet knows how most of these genetic variants play a role in myopia development, nor how best they can be used to target and improve treatment.

Teaching Overview

Currently I supervise final year students in the Cardiff University Eye Clinic.


























Research Topics and Related Projects

Genetic and environmental associations with refractive error in the Avon Longitudinal Study of Parents and Children (ALSPAC).

Collaborators: Cathy Williams, Beate St Pourcain, Kate Northstone.

The ALSPAC 'Children of the 90s' study is following the health and well-being of a group of UK children born in the early 1990's. The participants have taken part in a range of vision tests. In collaboration with researchers at the University of Bristol, I am trying to trace the causes of myopia development in this unique cohort.

The Consortium for Refractive Error and Myopia (CREAM)

Collaborators: More than 30 teams of researchers from across the world.

The CREAM consortium carry out collaborative projects designed to identify genetic risk factors for refractive errors. Projects are co-ordinated by working groups, involving teams of researchers with expertise in genetics, biostatistics and ophthalmology.   I co-Chair of the Astigmatism Working Group (with Joan Bailey-Wilson, NIH/NHGRI, USA) and the Longitudinal Studies Working Group (with Cathy Williams, Bristol, UK).  

Gene–Environment Interactions in Myopia

This project aims to discover gene variants that confer susceptibility to visually-induced myopia in an avian model.


JA Guggenheim(PI), PM Hocking, SP Yip, MR Frost, C Williams, HK$952,636, 'Gene–Environment Interactions in Myopia', GRF Project grant (PolyU 5610/13M) Hong Kong University Grants Council (UGC), 2014 – 2017.


Research Team   

Ms Rupal Shah, Postgraduate Student, 'Discovery of genetic determinants for refractive error', Cardiff University, 2014-2017


Research Collaborators

Dr Cathy Williams, Dr Beaté St Pourcain, Dr Kate Northstone, School of Social and Community Medicine, University of Bristol, 'Genetic and environmental associations with refractive error in the Avon Longitudinal Study of Parents and Children (ALSPAC)'.


Dr Paul Hocking, The Roslin Institute and Royal (Dick) School of Veterinary Science, University of Edinburgh, 'Gene–Environment Interactions in Myopia'.


Prof. Shea Ping Yip, Dr Chea-su Kee, Health Technology & Informatics, Hong Kong Polytechnic University, 'Gene–Environment Interactions in Myopia'.


Dr Michael R. Frost, School of Optometry, University of Alabama at Birmingham, 'Gene–Environment Interactions in Myopia'.


The UK Biobank Eye and Vision Consortium

The CREAM Consortium

Current Postgraduate Student (with degree and anticipated completion year)

Rupal Shah                    PhD                  2017

Yvonne Huang Yu MD    PhD                  2018 (Hong Kong)

Jeremy Kang Byung Soo  PhD                  2018 (Hong Kong)


Past Postgraduate Student (with degree and year submitted)

Michael Frost                 PhD                  2000

Natalie Davies               PhD                  2002

Jane Farbrother              PhD                  2003

Carolina Chan                PhD                  2005

Rosalind Creer               PhD                  2006

Lam Chuen                    PhD                  2007

Tetyana Zayats MD        PhD                  2009

Yen-Po (Paul) Chen MD   PhD                  2010

George McMahon          PhD                  2010

Chris Dillingham             PhD                  2012


Currently I supervise final year students in the Cardiff University Eye Clinic.


Educational and Professional Qualifications

1985-1988:      BSc (Hons) Optometry, UWIST (Cardiff University)

1988-1989:      PQE (Optometry)            , British College of Optometrists

1989-1992:      PhD, Cardiff University, UK

Anrhydeddau a dyfarniadau

2012/2013 College of Optometrists, Biennial Arthur Bennett Prize for Outstanding Research Anywhere in the World

Aelodaethau proffesiynol

2015 - present: Local Exhaust Ventilation Systems Working Group, Cardiff University

2013 - present:  Editorial Board Member for Investigative Ophthalmology and Visual Science (IOVS)

2013 - present:  Editorial Board Member, Biomedical Research International (BMRI)

2012 - present:  Associate Editor, Ophthalmic & Physiological Optics (OPO)

2012 - present:  Editorial Board Member, Translational Vision Science & Technology (TVST)

Safleoedd academaidd blaenorol

2013-2015       Assoc. Prof. & Assoc. Head, School of Optometry, Hong Kong Polytechnic University

2012-2013       Assoc. Prof., School of Optometry, Hong Kong Polytechnic University

2011-2012       Reader, School of Optometry & Vision Sciences, Cardiff University, UK.

2006-2011       Senior Lecturer, School of Optometry & Vision Sciences, Cardiff University, UK.

1994-2006       Lecturer, School of Optometry & Vision Sciences, Cardiff University, UK.

1992-1994       Wellcome Trust RA, Cardiff University, UK.

Pwyllgorau ac adolygu

2015 - present:  Research Committee

2015 - present:  Research Audit Ethics committee

2015 - present:  Safety, Health and Environment committee