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Dr Claudia Metzler-Baddeley
Darllenydd mewn Niwrowyddoniaeth Wybyddol a Delweddu Ymennydd Cymhwysol, Cymrawd Ymchwil Uwch NIHR/HCRW, Arweinydd ar gyfer Niwrowyddoniaeth Wybyddol
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Crynodeb ymchwil
Mae fy ymchwil yn canolbwyntio ar fecanweithiau gwybyddol a niwral heneiddio a niwroddirywiol (clefyd Alzheimer, clefyd corff Lewy, clefyd Huntington) ac ar gyfieithu canfyddiadau ar niwroplastigrwydd, dysgu a chof yn ymyriadau cymhleth i helpu i atal a rheoli heneiddio gwybyddol a dementia. Mae fy ngrŵp ymchwil yn defnyddio technegau MRI aml-barametrig meintiol datblygedig i archwilio microstrwythur meinwe'r ymennydd gyda'r nod o nodi biofarcwyr cynnar a marciwr delweddu surrogate ar gyfer treialon clinigol.
Mae fy ngrŵp ymchwil yn archwilio ymyriadau sy'n seiliedig ar gerddoriaeth, sy'n cynnwys caffael sgiliau synhwyraidd echddygol cymhleth fel dull hyfforddi ar gyfer swyddogaethau gwybyddol a motor wrth heneiddio a niwroddirywio. Rydym wedi cyd-ddylunio cais hyfforddi symudiadau rhythmig ar gyfer tabledi (HD-DRUM) i ysgogi swyddogaethau gwybyddol a modurol mewn pobl ag anhwylderau symud oherwydd clefyd Huntington (HD) neu glefyd Parkinson (prosiect DRUM) yn ogystal â hyfforddiant piano o bell (PIANO-Cog) ar gyfer oedolion hŷn. Mae'r ddau yn cael eu hasesu ar hyn o bryd mewn treialon dichonoldeb gan gynnwys asesiadau clinigol ac MRI.
Er mwyn astudio ffenoteipiau ymennydd o heneiddio a dementia risg mewn oedolion asymptomatig, rwyf wedi arwain Astudiaeth Heneiddio a Risg Dementia Caerdydd (CARDS) sydd wedi darganfod rhyngweithiadau newydd rhwng statws cludwr APOE4 a gordewdra ar ranbarthau limbig mater gwyn a llwyd sy'n awgrymu difrod meinwe oherwydd llid a symptomau cardiofasgwlaidd.
Cyhoeddiad
2024
- Short, E. et al. 2024. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. GeroScience (10.1007/s11357-024-01315-9)
- Ioakeimidis, V. et al. 2024. Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease. BMJ Open 14(7), article number: e082161. (10.1136/bmjopen-2023-082161)
- Rogers, F. and Metzler-Baddeley, C. 2024. The effects of musical instrument training on fluid intelligence and executive functions in healthy older adults: A systematic review and meta-analysis. Brain and Cognition 175, article number: 106137. (10.1016/j.bandc.2024.106137)
- Revie, L. and Metzler-Baddeley, C. 2024. Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making. Aging Brain 5, article number: 100106. (10.1016/j.nbas.2024.100106)
2023
- Revie, L. and Metzler-Baddeley, C. 2023. Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making. [Online]. bioRXiv. Available at: https://doi.org/10.1101/2023.11.15.567204
- Ioakeimidis, V. et al. 2023. Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington's disease. [Online]. medRxiv: medRxiv. (10.1101/2023.11.15.23298581) Available at: https://doi.org/10.1101/2023.11.15.23298581
- Metzler-Baddeley, C., Busse-Morris, M., Drew, C., Pallmann, P., Cantera Gomez, J., Ioakeimidis, V. and Rosser, A. 2023. HD-DRUM, a tablet-based drumming training App intervention for people with Huntington Disease: App development study. Journal of Medical Internet Research 2023(7), article number: e48395. (10.2196/48395)
- Casella, C. et al. 2023. Differences in white matter detected by ex vivo 9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease. [Online]. BioRXiv: BioRXiv. (10.1101/2023.10.02.560424) Available at: https://doi.org/10.1101/2023.10.02.560424
- Metzler-Baddeley, C., Busse, M., Drew, C., Pallmann, P., Cantera Gomez, J., Ioakeimidis, V. and Rosser, A. E. 2023. Applying an integrated knowledge translation framework approach to develop a tablet-based rhythmic movement training intervention for people with Huntington’s disease. [Online]. JMIR Preprints. (10.2196/preprints.48395) Available at: https://preprints.jmir.org/preprint/48395
2022
- Metzler-Baddeley, C., Busse, M. E., Drew, C. J., Pallmann, P., Jones, D. K. and Rosser, A. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September 2022, Vol. 93. Vol. S1. pp. A100-A101., (10.1136/jnnp-2022-ehdn.267)
- Casella, C. et al. 2022. Mutation-related magnetization-transfer, not axon density, drives white matter differences in premanifest Huntington's disease: Evidence from in vivo ultra-strong gradient MRI. Human Brain Mapping 43(11), pp. 3439-3460. (10.1002/hbm.25859)
- Coad, B., Ghomroudi, P. A., Sims, R., Aggleton, J., Vann, S. D. and Metzler-Baddeley, C. 2022. Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults. Neurobiology of Aging 113, pp. 39-54. (10.1016/j.neurobiolaging.2022.02.004)
- Lipp, I., Mole, J. P., Subramanian, L., Linden, D. E. J. and Metzler-Baddeley, C. 2022. Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease. Frontiers in Neurology 13, article number: 793693. (10.3389/fneur.2022.793693)
- Clarke, H., Messaritaki, E., Dimitriadis, S. and Metzler-Baddeley, C. 2022. Dementia risk factors modify hubs but leave other connectivity measures unchanged in asymptomatic individuals: a graph theoretical analysis. Brain Connectivity 12(1), pp. 26-40. (10.1089/brain.2020.0935)
2021
- Casella, C. et al. 2021. Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington's disease: evidence from in vivo ultra-strong gradient MRI. [Online]. bioRxiv. (10.1101/2021.11.29.469517) Available at: https://doi.org/10.1101/2021.11.29.469517
- Coad, B. M., Ghomroudi, P. A., Sims, R., Aggleton, J. P., Vann, S. D. and Metzler-Baddeley, C. 2021. Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.11.12.468385
- Casella, C. et al. 2021. Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease. NeuroImage: Clinical 30, article number: 102658. (10.1016/j.nicl.2021.102658)
2020
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Hamilton, D. A., Kidd, E. and Metzler-Baddeley, C. 2020. Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults. Neurobiology of Aging 94, pp. 298-310. (10.1016/j.neurobiolaging.2020.06.014)
- Casella, C. et al. 2020. Drumming motor sequence training induces apparent myelin remodelling in Huntington’s disease: a longitudinal diffusion MRI and quantitative magnetization transfer study. Journal of Huntington's Disease 9(3), pp. 303-320. (10.3233/JHD-200424)
- Casella, C., Rosser, A., Lipp, I., Jones, D. and Metzler-Baddeley, C. 2020. A critical review of white matter changes in Huntington’s disease. Movement Disorders 35(8), pp. 1302-1311. (10.1002/mds.28109)
- Revie, L., Hamilton, C., Ciafone, J., Donaghy, P. C., Thomas, A. and Metzler-Baddeley, C. 2020. Visuo-perceptual and decision-making contributions to visual hallucinations in mild cognitive impairment in Lewy body disease: insights from a drift diffusion analysis. Brain Sciences 10(8), article number: 540. (10.3390/brainsci10080540)
- Yhnell, E. et al. 2020. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD). Pilot and Feasibility Studies 6, article number: 88. (10.1186/s40814-020-00623-z)
- Coad, B., Craig, E., Louch, R., Aggleton, J., Vann, S. and Metzler-Baddeley, C. 2020. Precommissural and postcommissural fornix microstructure in healthy aging and cognition. Brain and Neuroscience Advances 4, pp. 1-12. (10.1177/2398212819899316)
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Kidd, E., Aggleton, J. and Metzler-Baddeley, C. 2020. APOE-e4-related differences in left thalamic microstructure in cognitively healthy adults. Scientific Reports 10, article number: 19787. (10.1038/s41598-020-75992-9)
- Revie, L., Bayer, A., Teufel, C. and Metzler-Baddeley, C. 2020. A review of the perceptual and attentional-executive characteristics of dementia with Lewy bodies relative to Alzheimer's and Parkinson's disease. PsyArXiv
2019
- Metzler-Baddeley, C. et al. 2019. Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure. NeuroImage 189, pp. 793-803. (10.1016/j.neuroimage.2019.02.007)
- Bourbon Teles, J., Bells, S., Jones, D. K., Coulthard, E., Rosser, A. and Metzler-Baddeley, C. 2019. Myelin breakdown in human Huntington's disease: multi-modal evidence from diffusion MRI and quantitative magnetization transfer. Neuroscience 403, pp. 79-92. (10.1016/j.neuroscience.2017.05.042)
- Metzler-Baddeley, C. et al. 2019. Fornix white matter glia damage causes hippocampal gray matter damage during age-dependent limbic decline. Scientific Reports 9, article number: 1060. (10.1038/s41598-018-37658-5)
- Hartopp, N., Wright, P., Ray, N., Evans, T., Metzler-Baddeley, C., Aggleton, J. and O'Sullivan, M. 2019. A key role for subiculum-fornix connectivity in recollection in older age. Frontiers in Systems Neuroscience 12, article number: 70. (10.3389/fnsys.2018.00070)
2018
- Furby, H., Yhnell, E., Mazzaschi, F., Mole, J., Busse, M., Rosser, A. E. and Metzler-Baddeley, C. 2018. Using 3T MRI to explore myelin break-down in pre-symptomatic huntington’s disease. Journal of Neurology, Neurosurgery and Psychiatry 89(S1), pp. A37-A38., article number: E06. (10.1136/jnnp-2018-EHDN.100)
- Bubb, E., Metzler-Baddeley, C. and Aggleton, J. 2018. The cingulum bundle: anatomy, function, and dysfunction. Neuroscience and Biobehavioral Reviews 92, pp. 104-127. (10.1016/j.neubiorev.2018.05.008)
- Yhnell, E. et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4, article number: 45. (10.1186/s40814-018-0237-0)
- Caeyenberghs, K. et al. 2018. Evidence for training-dependent structural neuroplasticity in brain-injured patients: A critical review. Neurorehabilitation and Neural Repair 32(2), pp. 99-114. (10.1177/1545968317753076)
2017
- Gan, C. L., O'Sullivan, M. J., Metzler-Baddeley, C. and Halpin, S. 2017. Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment. Clinical Radiology 72(11), pp. 915-922. (10.1016/j.crad.2017.04.021)
- Metzler-Baddeley, C., Foley, S., De Santis, S., Charron, C., Hampshire, A., Caeyenberghs, K. and Jones, D. 2017. Dynamics of white matter plasticity underlying working memory training: Multi-modal evidence from diffusion MRI and relaxometry. Journal of Cognitive Neuroscience 29(9), pp. 1509-1520. (10.1162/jocn_a_01127)
2016
- Christiansen, K., Metzler-Baddeley, C., Parker, G., Muhlert, N., Jones, D. K., Aggleton, J. P. and Vann, S. D. 2016. Topographic separation of fornical fibers associated with the anterior and posterior hippocampus in the human brain: an MRI-diffusion study. Brain and Behavior 7(1) (10.1002/brb3.604)
- Rok, B., Metzler-Baddeley, C., Arfan, I. M., Jones, D. and O'Sullivan, M. 2016. Global efficiency of structural networks mediates cognitive control in Mild Cognitive Impairment. Frontiers in Aging Neuroscience 8, article number: 292. (10.3389/fnagi.2016.00292)
- Mole, J. P., Subramanian, L., Bracht, T., Morris, H., Metzler-Baddeley, C. and Linden, D. E. J. 2016. Increased fractional anisotropy in the motor tracts of Parkinson's disease suggests compensatory neuroplasticity or selective neurodegeneration. European Radiology 26(10), pp. 3327-3335. (10.1007/s00330-015-4178-1)
- Metzler-Baddeley, C., Caeyenberghs, K., Foley, S. and Jones, D. K. 2016. Longitudinal data on cortical thickness before and after working memory training. Data in Brief 7, pp. 1143-1147. (10.1016/j.dib.2016.03.090)
- Metzler-Baddeley, C., Caeyenberghs, K., Foley, S. and Jones, D. K. 2016. Task complexity and location specific changes of cortical thickness in executive and salience networks after working memory training. NeuroImage 130, pp. 48-62. (10.1016/j.neuroimage.2016.01.007)
- Christiansen, K., Aggleton, J. P., Parker, G. D., O'Sullivan, M. J., Vann, S. D. and Metzler-Baddeley, C. 2016. The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study. NeuroImage 130, pp. 35-47. (10.1016/j.neuroimage.2015.12.055)
- Caeyenberghs, K., Metzler-Baddeley, C., Foley, S. and Jones, D. K. 2016. Dynamics of the human structural connectome underlying working memory training. Journal of Neuroscience 36(14), pp. 4056-4066. (10.1523/JNEUROSCI.1973-15.2016)
2015
- Kehoe, E. G. et al. 2015. Fornix white matter is correlated with resting state functional connectivity of the thalamus and hippocampus in healthy aging but not in mild cognitive impairment- a preliminary study. Frontiers in Aging Neuroscience 7, article number: 10. (10.3389/fnagi.2015.00010)
- Ray, N. J. et al. 2015. Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience 35(2), pp. 739-747. (10.1523/JNEUROSCI.3617-14.2015)
- Gomez, P. A., Sperl, J. I., Sprenger, T., Metzler-Baddeley, C., Jones, D. K. and Saemann, P. 2015. Joint reconstruction of multi-contrast MRI for Multiple Sclerosis lesion segmentation. Bildverarbeitung fuer die Medizin 2015, pp. 155-160. (10.1007/978-3-662-46224-9_28)
2014
- Berlot, R., Metzler-Baddeley, C., Jones, D. K. and O'Sullivan, M. J. 2014. CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment. NeuroImage 92, pp. 27-35. (10.1016/j.neuroimage.2014.01.031)
- Metzler-Baddeley, C., Cantera, J., Coulthard, E., Rosser, A. E., Jones, D. K. and Baddeley, R. J. 2014. Improved executive function and callosal white matter microstructure after rhythmn exercise in Huntington's disease. Journal of Huntington's Disease 3(3), pp. 273-283. (10.3233/JHD-140113)
2013
- Metzler-Baddeley, C., Baddeley, R. J., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. 2013. Individual differences in fornix microstructure and body mass index. PLoS ONE 8(3), article number: e59849. (10.1371/journal.pone.0059849)
2012
- Metzler-Baddeley, C., Jones, D. K., Steventon, J., Westacott, L., Aggleton, J. P. and O'Sullivan, M. 2012. Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience 32(49), pp. 17612-17619. (10.1523/JNEUROSCI.3299-12.2012)
- Metzler-Baddeley, C., Hunt, S., Jones, D. K., Leemans, A., Aggleton, J. P. and O'Sullivan, M. 2012. Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology 79(23), pp. 2233-2240. (10.1212/WNL.0b013e31827689e8)
- Metzler-Baddeley, C., O'Sullivan, M., Bells, S., Pasternak, O. and Jones, D. K. 2012. How and how not to correct for CSF-contamination in diffusion MRI. Neuroimage 59(2), pp. 1394-1403. (10.1016/j.neuroimage.2011.08.043)
2011
- Metzler-Baddeley, C., Jones, D. K., Belaroussi, B., Aggleton, J. P. and O'Sullivan, M. 2011. Frontotemporal connections in episodic memory and aging: A diffusion MRI tractography study. The Journal of Neuroscience 31(37), pp. 13236-13245. (10.1523/JNEUROSCI.2317-11.2011)
- Metzler-Baddeley, C., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. 2011. The fornix in ageing and memory decline: a diffusion MRI tractography study. Journal of Neurology 258(S1), pp. 18-18. (10.1007/s00415-011-6026-9)
2010
- Metzler-Baddeley, C., Baddeley, R. J., Lovell, P. G., Laffan, A. and Jones, R. W. 2010. Visual impairments in dementia with Lewy bodies and posterior cortical atrophy.. Neuropsychology 24(1), pp. 35-48. (10.1037/a0016834)
- Metzler-Baddeley, C. and Jones, R. W. 2010. Brief Communication: Cognitive Rehabilitation of Executive Functioning in a Case of Craniopharyngioma. Applied Neuropsychology 17(4), pp. 299-304. (10.1080/09084282.2010.523394)
- Laffan, A. J., Metzler-Baddeley, C., Walker, I. and Jones, R. W. 2010. Making errorless learning more active: Self-generation in an error free learning context is superior to standard errorless learning of face-name associations in people with Alzheimer's disease. Neuropsychological Rehabilitation 20(2), pp. 197-211. (10.1080/09602010903202432)
2009
- Metzler-Baddeley, C., Baddeley, R. J., Lovell, P. G. and Jones, R. W. 2009. Visual impairment in posterior cortical atrophy and dementia with lewy bodies [Abstract]. Alzheimer's and Dementia 5(4), pp. P458. (10.1016/j.jalz.2009.04.862)
- Metzler-Baddeley, C. and Baddeley, R. J. 2009. Does adaptive training work?. Applied Cognitive Psychology 23(2), pp. 254-266. (10.1002/acp.1454)
2008
- Metzler-Baddeley, C., Salter, A. and Jones, R. W. 2008. The significance of dyslexia screening for the assessment of dementia in older people. International Journal of Geriatric Psychiatry 23(7), pp. 766-768. (10.1002/gps.1957)
2007
- Metzler-Baddeley, C. 2007. A Review of Cognitive Impairments in Dementia with Lewy Bodies Relative to Alzheimer's Disease and Parkinson's Disease with Dementia. Cortex 43(5), pp. 583-600. (10.1016/S0010-9452(08)70489-1)
2005
- Metzler-Baddeley, C. and Snowden, J. S. 2005. Brief Report: Errorless versus Errorful Learning as a Memory Rehabilitation Approach in Alzheimer's Disease. Journal of Clinical and Experimental Neuropsychology 27(8), pp. 1070-1079. (10.1080/13803390490919164)
2001
- Metzler-Baddeley, C. 2001. Location negative priming may be abolished in older age. Zeitschrift für Gerontopsychologie & -psychiatrie 14(4), pp. 187-202. (10.1024//1011-6877.14.4.187)
- Metzler-Baddeley, C. 2001. Effects of left frontal lesions on the selection of context-appropriate meanings. Neuropsychology 15(3), pp. 315-328. (10.1037/0894-4105.15.3.315)
2000
- Metzler-Baddeley, C. and Parkin, A. J. 2000. Reversed negative priming following frontal lobe lesions. Neuropsychologia 38(4), pp. 363-379. (10.1016/S0028-3932(99)00097-4)
1996
- Parkin, A. J., Bindschaedler, C., Harsent, L. and Metzler-Baddeley, C. 1996. Pathological false alarm rates following damage to the left frontal cortex. Brain and Cognition 32(1), pp. 14-27. (10.1006/brcg.1996.0055)
Articles
- Short, E. et al. 2024. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. GeroScience (10.1007/s11357-024-01315-9)
- Ioakeimidis, V. et al. 2024. Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease. BMJ Open 14(7), article number: e082161. (10.1136/bmjopen-2023-082161)
- Rogers, F. and Metzler-Baddeley, C. 2024. The effects of musical instrument training on fluid intelligence and executive functions in healthy older adults: A systematic review and meta-analysis. Brain and Cognition 175, article number: 106137. (10.1016/j.bandc.2024.106137)
- Revie, L. and Metzler-Baddeley, C. 2024. Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making. Aging Brain 5, article number: 100106. (10.1016/j.nbas.2024.100106)
- Metzler-Baddeley, C., Busse-Morris, M., Drew, C., Pallmann, P., Cantera Gomez, J., Ioakeimidis, V. and Rosser, A. 2023. HD-DRUM, a tablet-based drumming training App intervention for people with Huntington Disease: App development study. Journal of Medical Internet Research 2023(7), article number: e48395. (10.2196/48395)
- Casella, C. et al. 2022. Mutation-related magnetization-transfer, not axon density, drives white matter differences in premanifest Huntington's disease: Evidence from in vivo ultra-strong gradient MRI. Human Brain Mapping 43(11), pp. 3439-3460. (10.1002/hbm.25859)
- Coad, B., Ghomroudi, P. A., Sims, R., Aggleton, J., Vann, S. D. and Metzler-Baddeley, C. 2022. Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults. Neurobiology of Aging 113, pp. 39-54. (10.1016/j.neurobiolaging.2022.02.004)
- Lipp, I., Mole, J. P., Subramanian, L., Linden, D. E. J. and Metzler-Baddeley, C. 2022. Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease. Frontiers in Neurology 13, article number: 793693. (10.3389/fneur.2022.793693)
- Clarke, H., Messaritaki, E., Dimitriadis, S. and Metzler-Baddeley, C. 2022. Dementia risk factors modify hubs but leave other connectivity measures unchanged in asymptomatic individuals: a graph theoretical analysis. Brain Connectivity 12(1), pp. 26-40. (10.1089/brain.2020.0935)
- Casella, C. et al. 2021. Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease. NeuroImage: Clinical 30, article number: 102658. (10.1016/j.nicl.2021.102658)
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Hamilton, D. A., Kidd, E. and Metzler-Baddeley, C. 2020. Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults. Neurobiology of Aging 94, pp. 298-310. (10.1016/j.neurobiolaging.2020.06.014)
- Casella, C. et al. 2020. Drumming motor sequence training induces apparent myelin remodelling in Huntington’s disease: a longitudinal diffusion MRI and quantitative magnetization transfer study. Journal of Huntington's Disease 9(3), pp. 303-320. (10.3233/JHD-200424)
- Casella, C., Rosser, A., Lipp, I., Jones, D. and Metzler-Baddeley, C. 2020. A critical review of white matter changes in Huntington’s disease. Movement Disorders 35(8), pp. 1302-1311. (10.1002/mds.28109)
- Revie, L., Hamilton, C., Ciafone, J., Donaghy, P. C., Thomas, A. and Metzler-Baddeley, C. 2020. Visuo-perceptual and decision-making contributions to visual hallucinations in mild cognitive impairment in Lewy body disease: insights from a drift diffusion analysis. Brain Sciences 10(8), article number: 540. (10.3390/brainsci10080540)
- Yhnell, E. et al. 2020. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD). Pilot and Feasibility Studies 6, article number: 88. (10.1186/s40814-020-00623-z)
- Coad, B., Craig, E., Louch, R., Aggleton, J., Vann, S. and Metzler-Baddeley, C. 2020. Precommissural and postcommissural fornix microstructure in healthy aging and cognition. Brain and Neuroscience Advances 4, pp. 1-12. (10.1177/2398212819899316)
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Kidd, E., Aggleton, J. and Metzler-Baddeley, C. 2020. APOE-e4-related differences in left thalamic microstructure in cognitively healthy adults. Scientific Reports 10, article number: 19787. (10.1038/s41598-020-75992-9)
- Revie, L., Bayer, A., Teufel, C. and Metzler-Baddeley, C. 2020. A review of the perceptual and attentional-executive characteristics of dementia with Lewy bodies relative to Alzheimer's and Parkinson's disease. PsyArXiv
- Metzler-Baddeley, C. et al. 2019. Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure. NeuroImage 189, pp. 793-803. (10.1016/j.neuroimage.2019.02.007)
- Bourbon Teles, J., Bells, S., Jones, D. K., Coulthard, E., Rosser, A. and Metzler-Baddeley, C. 2019. Myelin breakdown in human Huntington's disease: multi-modal evidence from diffusion MRI and quantitative magnetization transfer. Neuroscience 403, pp. 79-92. (10.1016/j.neuroscience.2017.05.042)
- Metzler-Baddeley, C. et al. 2019. Fornix white matter glia damage causes hippocampal gray matter damage during age-dependent limbic decline. Scientific Reports 9, article number: 1060. (10.1038/s41598-018-37658-5)
- Hartopp, N., Wright, P., Ray, N., Evans, T., Metzler-Baddeley, C., Aggleton, J. and O'Sullivan, M. 2019. A key role for subiculum-fornix connectivity in recollection in older age. Frontiers in Systems Neuroscience 12, article number: 70. (10.3389/fnsys.2018.00070)
- Furby, H., Yhnell, E., Mazzaschi, F., Mole, J., Busse, M., Rosser, A. E. and Metzler-Baddeley, C. 2018. Using 3T MRI to explore myelin break-down in pre-symptomatic huntington’s disease. Journal of Neurology, Neurosurgery and Psychiatry 89(S1), pp. A37-A38., article number: E06. (10.1136/jnnp-2018-EHDN.100)
- Bubb, E., Metzler-Baddeley, C. and Aggleton, J. 2018. The cingulum bundle: anatomy, function, and dysfunction. Neuroscience and Biobehavioral Reviews 92, pp. 104-127. (10.1016/j.neubiorev.2018.05.008)
- Yhnell, E. et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4, article number: 45. (10.1186/s40814-018-0237-0)
- Caeyenberghs, K. et al. 2018. Evidence for training-dependent structural neuroplasticity in brain-injured patients: A critical review. Neurorehabilitation and Neural Repair 32(2), pp. 99-114. (10.1177/1545968317753076)
- Gan, C. L., O'Sullivan, M. J., Metzler-Baddeley, C. and Halpin, S. 2017. Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment. Clinical Radiology 72(11), pp. 915-922. (10.1016/j.crad.2017.04.021)
- Metzler-Baddeley, C., Foley, S., De Santis, S., Charron, C., Hampshire, A., Caeyenberghs, K. and Jones, D. 2017. Dynamics of white matter plasticity underlying working memory training: Multi-modal evidence from diffusion MRI and relaxometry. Journal of Cognitive Neuroscience 29(9), pp. 1509-1520. (10.1162/jocn_a_01127)
- Christiansen, K., Metzler-Baddeley, C., Parker, G., Muhlert, N., Jones, D. K., Aggleton, J. P. and Vann, S. D. 2016. Topographic separation of fornical fibers associated with the anterior and posterior hippocampus in the human brain: an MRI-diffusion study. Brain and Behavior 7(1) (10.1002/brb3.604)
- Rok, B., Metzler-Baddeley, C., Arfan, I. M., Jones, D. and O'Sullivan, M. 2016. Global efficiency of structural networks mediates cognitive control in Mild Cognitive Impairment. Frontiers in Aging Neuroscience 8, article number: 292. (10.3389/fnagi.2016.00292)
- Mole, J. P., Subramanian, L., Bracht, T., Morris, H., Metzler-Baddeley, C. and Linden, D. E. J. 2016. Increased fractional anisotropy in the motor tracts of Parkinson's disease suggests compensatory neuroplasticity or selective neurodegeneration. European Radiology 26(10), pp. 3327-3335. (10.1007/s00330-015-4178-1)
- Metzler-Baddeley, C., Caeyenberghs, K., Foley, S. and Jones, D. K. 2016. Longitudinal data on cortical thickness before and after working memory training. Data in Brief 7, pp. 1143-1147. (10.1016/j.dib.2016.03.090)
- Metzler-Baddeley, C., Caeyenberghs, K., Foley, S. and Jones, D. K. 2016. Task complexity and location specific changes of cortical thickness in executive and salience networks after working memory training. NeuroImage 130, pp. 48-62. (10.1016/j.neuroimage.2016.01.007)
- Christiansen, K., Aggleton, J. P., Parker, G. D., O'Sullivan, M. J., Vann, S. D. and Metzler-Baddeley, C. 2016. The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study. NeuroImage 130, pp. 35-47. (10.1016/j.neuroimage.2015.12.055)
- Caeyenberghs, K., Metzler-Baddeley, C., Foley, S. and Jones, D. K. 2016. Dynamics of the human structural connectome underlying working memory training. Journal of Neuroscience 36(14), pp. 4056-4066. (10.1523/JNEUROSCI.1973-15.2016)
- Kehoe, E. G. et al. 2015. Fornix white matter is correlated with resting state functional connectivity of the thalamus and hippocampus in healthy aging but not in mild cognitive impairment- a preliminary study. Frontiers in Aging Neuroscience 7, article number: 10. (10.3389/fnagi.2015.00010)
- Ray, N. J. et al. 2015. Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience 35(2), pp. 739-747. (10.1523/JNEUROSCI.3617-14.2015)
- Gomez, P. A., Sperl, J. I., Sprenger, T., Metzler-Baddeley, C., Jones, D. K. and Saemann, P. 2015. Joint reconstruction of multi-contrast MRI for Multiple Sclerosis lesion segmentation. Bildverarbeitung fuer die Medizin 2015, pp. 155-160. (10.1007/978-3-662-46224-9_28)
- Berlot, R., Metzler-Baddeley, C., Jones, D. K. and O'Sullivan, M. J. 2014. CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment. NeuroImage 92, pp. 27-35. (10.1016/j.neuroimage.2014.01.031)
- Metzler-Baddeley, C., Cantera, J., Coulthard, E., Rosser, A. E., Jones, D. K. and Baddeley, R. J. 2014. Improved executive function and callosal white matter microstructure after rhythmn exercise in Huntington's disease. Journal of Huntington's Disease 3(3), pp. 273-283. (10.3233/JHD-140113)
- Metzler-Baddeley, C., Baddeley, R. J., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. 2013. Individual differences in fornix microstructure and body mass index. PLoS ONE 8(3), article number: e59849. (10.1371/journal.pone.0059849)
- Metzler-Baddeley, C., Jones, D. K., Steventon, J., Westacott, L., Aggleton, J. P. and O'Sullivan, M. 2012. Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience 32(49), pp. 17612-17619. (10.1523/JNEUROSCI.3299-12.2012)
- Metzler-Baddeley, C., Hunt, S., Jones, D. K., Leemans, A., Aggleton, J. P. and O'Sullivan, M. 2012. Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology 79(23), pp. 2233-2240. (10.1212/WNL.0b013e31827689e8)
- Metzler-Baddeley, C., O'Sullivan, M., Bells, S., Pasternak, O. and Jones, D. K. 2012. How and how not to correct for CSF-contamination in diffusion MRI. Neuroimage 59(2), pp. 1394-1403. (10.1016/j.neuroimage.2011.08.043)
- Metzler-Baddeley, C., Jones, D. K., Belaroussi, B., Aggleton, J. P. and O'Sullivan, M. 2011. Frontotemporal connections in episodic memory and aging: A diffusion MRI tractography study. The Journal of Neuroscience 31(37), pp. 13236-13245. (10.1523/JNEUROSCI.2317-11.2011)
- Metzler-Baddeley, C., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. 2011. The fornix in ageing and memory decline: a diffusion MRI tractography study. Journal of Neurology 258(S1), pp. 18-18. (10.1007/s00415-011-6026-9)
- Metzler-Baddeley, C., Baddeley, R. J., Lovell, P. G., Laffan, A. and Jones, R. W. 2010. Visual impairments in dementia with Lewy bodies and posterior cortical atrophy.. Neuropsychology 24(1), pp. 35-48. (10.1037/a0016834)
- Metzler-Baddeley, C. and Jones, R. W. 2010. Brief Communication: Cognitive Rehabilitation of Executive Functioning in a Case of Craniopharyngioma. Applied Neuropsychology 17(4), pp. 299-304. (10.1080/09084282.2010.523394)
- Laffan, A. J., Metzler-Baddeley, C., Walker, I. and Jones, R. W. 2010. Making errorless learning more active: Self-generation in an error free learning context is superior to standard errorless learning of face-name associations in people with Alzheimer's disease. Neuropsychological Rehabilitation 20(2), pp. 197-211. (10.1080/09602010903202432)
- Metzler-Baddeley, C., Baddeley, R. J., Lovell, P. G. and Jones, R. W. 2009. Visual impairment in posterior cortical atrophy and dementia with lewy bodies [Abstract]. Alzheimer's and Dementia 5(4), pp. P458. (10.1016/j.jalz.2009.04.862)
- Metzler-Baddeley, C. and Baddeley, R. J. 2009. Does adaptive training work?. Applied Cognitive Psychology 23(2), pp. 254-266. (10.1002/acp.1454)
- Metzler-Baddeley, C., Salter, A. and Jones, R. W. 2008. The significance of dyslexia screening for the assessment of dementia in older people. International Journal of Geriatric Psychiatry 23(7), pp. 766-768. (10.1002/gps.1957)
- Metzler-Baddeley, C. 2007. A Review of Cognitive Impairments in Dementia with Lewy Bodies Relative to Alzheimer's Disease and Parkinson's Disease with Dementia. Cortex 43(5), pp. 583-600. (10.1016/S0010-9452(08)70489-1)
- Metzler-Baddeley, C. and Snowden, J. S. 2005. Brief Report: Errorless versus Errorful Learning as a Memory Rehabilitation Approach in Alzheimer's Disease. Journal of Clinical and Experimental Neuropsychology 27(8), pp. 1070-1079. (10.1080/13803390490919164)
- Metzler-Baddeley, C. 2001. Location negative priming may be abolished in older age. Zeitschrift für Gerontopsychologie & -psychiatrie 14(4), pp. 187-202. (10.1024//1011-6877.14.4.187)
- Metzler-Baddeley, C. 2001. Effects of left frontal lesions on the selection of context-appropriate meanings. Neuropsychology 15(3), pp. 315-328. (10.1037/0894-4105.15.3.315)
- Metzler-Baddeley, C. and Parkin, A. J. 2000. Reversed negative priming following frontal lobe lesions. Neuropsychologia 38(4), pp. 363-379. (10.1016/S0028-3932(99)00097-4)
- Parkin, A. J., Bindschaedler, C., Harsent, L. and Metzler-Baddeley, C. 1996. Pathological false alarm rates following damage to the left frontal cortex. Brain and Cognition 32(1), pp. 14-27. (10.1006/brcg.1996.0055)
Conferences
- Metzler-Baddeley, C., Busse, M. E., Drew, C. J., Pallmann, P., Jones, D. K. and Rosser, A. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September 2022, Vol. 93. Vol. S1. pp. A100-A101., (10.1136/jnnp-2022-ehdn.267)
Websites
- Revie, L. and Metzler-Baddeley, C. 2023. Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making. [Online]. bioRXiv. Available at: https://doi.org/10.1101/2023.11.15.567204
- Ioakeimidis, V. et al. 2023. Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington's disease. [Online]. medRxiv: medRxiv. (10.1101/2023.11.15.23298581) Available at: https://doi.org/10.1101/2023.11.15.23298581
- Casella, C. et al. 2023. Differences in white matter detected by ex vivo 9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease. [Online]. BioRXiv: BioRXiv. (10.1101/2023.10.02.560424) Available at: https://doi.org/10.1101/2023.10.02.560424
- Metzler-Baddeley, C., Busse, M., Drew, C., Pallmann, P., Cantera Gomez, J., Ioakeimidis, V. and Rosser, A. E. 2023. Applying an integrated knowledge translation framework approach to develop a tablet-based rhythmic movement training intervention for people with Huntington’s disease. [Online]. JMIR Preprints. (10.2196/preprints.48395) Available at: https://preprints.jmir.org/preprint/48395
- Casella, C. et al. 2021. Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington's disease: evidence from in vivo ultra-strong gradient MRI. [Online]. bioRxiv. (10.1101/2021.11.29.469517) Available at: https://doi.org/10.1101/2021.11.29.469517
- Coad, B. M., Ghomroudi, P. A., Sims, R., Aggleton, J. P., Vann, S. D. and Metzler-Baddeley, C. 2021. Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.11.12.468385
Ymchwil
Pynciau ymchwil a phapurau cysylltiedig
HD-DRUM: hyfforddiant gwybyddol a modur, plastigrwydd yr ymennydd, clefyd Huntington
CARDIAU: Ffactorau heneiddio / risg iach a phathologaidd dementia
Clefydau niwroddirywiol (clefyd Alzheimer, clefyd corff Lewy, clefyd Huntington)
Modelau niwroglia o heneiddio a niwroddirywiol
Anatomeg llwybrau mater gwyn limbig
Cyllid
Metzler-Baddeley, C (PI) (2022-2026) Datblygu a dichonoldeb astudiaeth beilot rheoledig ar hap o HD-DRUM - ap hyfforddi dilyniant modur newydd ar gyfer pobl â chlefyd Huntington. Cymrodoriaeth Ymchwil Uwch y Sefydliad Cenedlaethol ar gyfer Ymchwil Iechyd (NIHR) / Cymrodoriaeth Ymchwil Uwch Gofal ac Ymchwil Iechyd Cymru (HCRW). £917,217.
Drew, C, Hamana, K, McLauchlan, D, Lewis, A, Pallmann, P, Jacob, N & Metzler-Baddeley, C (2024-2026). Gwerthuso dichonoldeb anadlais taro'r samba ar gyfer pobl â chlefyd Parkinson (SParky Samba). Sefydliad Jacques & Gloria Gossweiler, £520,705.
Duckers, J et al (CoA) (2019) Ffibrosis Systig - Asesiad cof a sgrinio MRI. Ymchwil Iechyd a Gofal Cymru. £19,200.
Rosser, A, Busse, M & Metzler-Baddeley (2016) Archwilio hyfforddiant gwybyddol fel ymyrraeth anfferyllol i bobl â chlefyd Huntington. Sefydliad Jaque a Gloria Gossweiler £94,714.
Metzler-Baddeley C (PI) (2014) Sut mae gwahaniaethau unigol mewn adiposity canol oed a genoteip APOE fel ffactorau risg ar gyfer dementia yn effeithio ar strwythur a gwybyddiaeth? Astudiaeth MRI trawstoriadol Cymdeithas Alzheimer a Chymrodoriaeth BRACE £305,161.
Metzler-Baddeley, C (PI), Jones, DK, Rosser AE. (2014) Effeithiau ymyrraeth newydd ar ficrostrwythur a gwybyddiaeth mater gwyn yng nghlwy'r Huntington. Grant prosiect ISSF NISCHR ac Ymddiriedolaeth Croeso. £69,769.
Grŵp ymchwil
CUBRIC
Niwrowyddoniaeth Gwybyddol
Delweddu Gwyddoniaeth
Cydweithredwyr ymchwil
- Yr Athro Derek Jones (Caerdydd)
- Yr Athro David Linden (Caerdydd)
- Yr Athro Anne Rosser (Caerdydd)
- Yr Athro John Aggleton (Caerdydd)
- Dr Seralynne Vann (Caerdydd)
- Yr Athro Monica Busse (Caerdydd)
- Dr John Evans (Caerdydd)
- Dr Rebecca Sims (Caerdydd)
- Dr Emma Kidd (Caerdydd)
- Fabrizio Fasano (Siemens)
- Dr Elizabeth Coulthard (Bryste)
- Dr Roland J Baddeley (Bryste)
- Yr Athro Karen Caeyenberghs (Prifysgol Deakin, Awstralia)
- Yr Athro Michael O'Sullivan (Prifysgol Queensland, Awstralia)
- Yr Athro Fernando Maestu (Prifysgol Madrid, Sbaen)
- Dr Michael Funke (Prifysgol Texas, UDA)
- Yr Athro Derek Hamilton (Prifysgol New Mexico, UDA)
Cyfryngau
- Beth mae CUBRIC yn ei olygu i chi? https://youtu.be/1OB2krtm434
- Good Night Wales, BBC Radio Wales (11/12/2018)
- ITV Cymru (23/04/18).
- BBC Cymru http://www.bbc.co.uk/news/uk-wales-36286847,
- Gwarcheidwad - https://www.theguardian.com/science/2016/aug/04/brains-of-overweight-people-look-ten-years-older-than-those-of-lean-peers (4/08/16)
- Rhaglen Panorama "Byw gyda Dementia – Stori Chris yn cael ei darlledu ar BBC One (2/06/16).
- Digwyddiad Pint of Science Caerdydd ar blastigrwydd yr ymennydd (11/05/18)
- Dogfennaeth y BBC ar Terry Pratchett Living with Alzheimer's, darlledwyd Chwefror 2009 https://www.bbc.co.uk/programmes/b00hhgsb
- Profiad Coffa BBC Radio 4
Addysgu
Rwy'n darlithio ar fodiwlau BSc Seicoleg Blwyddyn 1 Cyflwyniad i Seicoleg (PS1016), Prosesau ac Anhwylderau Cof modiwl Blwyddyn 3 (PS3208), a MSc Pynciau mewn Seicoleg (PST720).
Bywgraffiad
Addysg israddedig
Seicoleg ym Mhrifysgol Bonn, yr Almaen
Addysg ôl-raddedig
D.Phil yn gweithio ar ddiffygion sylw blaen ym Mhrifysgol Sussex
Cyflogaeth
Cymrawd Ymchwil Uwch NIHR/HCRW (2022-2025)
Darllenydd mewn Niwrowyddoniaeth Wybyddol, Prifysgol Caerdydd (2020-presennol)
Uwch Ddarlithydd, Prifysgol Caerdydd (2016-2020)
Cymdeithas Alzheimer a Chymrawd Ymchwil BRACE (2014-2018)
Cydymaith Ymchwil, Prifysgol Caerdydd (2009-2014)
Niwroseicolegydd yn y Sefydliad Ymchwil ar gyfer Gofal Pobl Hŷn (RICE) yng Nghaerfaddon (2005-2009)
Darlithyddiaeth mewn Seicoleg ym Mhrifysgol Manceinion a gwaith ôl-ddoethurol yn y Sefydliad Seiciatreg, King's College Llundain
Anrhydeddau a dyfarniadau
Gwobrau/Pwyllgorau Allanol
Seicolegydd Siartredig (CPsychol) a Chymrawd Cyswllt Cymdeithas Seicolegol Prydain (AFBPsS).
Aelod o'r Bwrdd Cynghori Gwyddonol, elusen BRACE Alzheimer
Aelod o UKRI BBSRC Aging Across the Lifecourse Working Group
Aelod o'r bwrdd golygyddol ar gyfer Adroddiadau Gwyddonol (NPG)
Aelodaethau proffesiynol
Cymdeithas Niwrowyddoniaeth (SfN)
Cymdeithas Niwrowyddoniaeth Wybyddol (CNS)
Sefydliad Mapio Ymennydd Dynol (OHBM)
Cymdeithas Ryngwladol ar gyfer Cyseiniant Magnetig mewn Meddygaeth (ISMRM)
Meysydd goruchwyliaeth
Cyswllt ymchwil ôl-ddoethurol: Dr Pedro Luque-Laguna (ariannwyd gan NIHR/HCRW Uwch Gymrodoriaeth)
Myfyrwyr PhD cyfredol yn ymchwilio plastigrwydd yr ymennydd wrth heneiddio: Lucy Layland (Ysgol Seicoleg Efrydiaeth PhD Agored 2022-2025), Fionnuala Rogers (Ysgol Seicoleg Efrydiaeth PhD Agored 2021-2024)
Cynorthwywyr Seicoleg: Annabel Geddes a Beate Galoburda
Myfyrwyr PhD blaenorol: Chiara Casella, Lauren Revie, Jilu Mole, Kat Christiansen
Contact Details
Metzler-BaddeleyC@caerdydd.ac.uk
+44 29208 70705
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
+44 29208 70705
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
