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Claudia Metzler-Baddeley

Dr Claudia Metzler-Baddeley

Reader, NIHR/HCRW Advanced Research Fellow, Lead of Cognitive Neuroscience

School of Psychology

Email
Metzler-BaddeleyC@cardiff.ac.uk
Telephone
+44 29208 70705
Campuses
Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ
Users
Available for postgraduate supervision

Overview

Research summary

I am a cognitive neuroscientist interested in: 

  • translating findings from cognitive psychology and neuroscience to clinical application (complex interventions) for people with brain disease/injury

I have led the development of a tablet-based rhythmic movement (drumming) training application (HD-DRUM) to stimulate cognitive and motor functions in people with movement disorders such as Huntington's disease (HD). My research team (Vasilis Ioakeimidis, Lucy Layland, Fionnuala Rogers, Amy Dangerfield) studies feasibility,  clinical effects and their underpinning brain mechanisms (with MRI) of HD-DRUM and other music-based interventions (learning to play the piano) in people with HD and in older adults.

  • understanding the cognitive and brain phenotypes of healthy versus pathological ageing (associated with dementia risk factors) to identify early disease biomarkers

I have led the Cardiff Ageing and Risk of Dementia Study (CARDS) that has discovered novel interactions between genetic (APOE4 carrier status) and lifestyle (obesity) risk factors of dementia on brain matter in limbic regions suggestive of tissue damage due to inflammation and hypertension. 

 

 

Publication

2024

2023

2022

2021

2020

2019

2018

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2016

2015

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2012

2011

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2009

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1996

Cynadleddau

Erthyglau

Gwefannau

Research

Research topics and related papers

HD-DRUM: cognitive and motor training, brain plasticity, Huntington's disease

CARDS: Healthy and pathological ageing/ risk factors of dementia

Neurodegenerative diseases (Alzheimer's disease, Lewy body disease, Huntington's disease)

Neuroglia models of ageing and neurodegeneration

Anatomy of limbic white matter pathways

Funding

Metzler-Baddeley, C (PI) (2022-2026) Development and feasibility randomised controlled pilot study of HD-DRUM – a novel motor sequence training app for people with Huntington’s disease. National Institute for Health Research (NIHR)/ Health Care and Research Wales (HCRW) Advanced Research Fellowship. £917,217.

Duckers, J et al (CoA) (2019) Cystic Fibrosis - Memory assessment and MRI screening. Health & Care Research Wales. £19,200.

Rosser, A, Busse, M & Metzler-Baddeley (2016) Exploring cognitive training as a non-pharmaceutical intervention for people with Huntington's disease. Jaque and Gloria Gossweiler Foundation. £94,714.

Metzler-Baddeley  C (PI) (2014) How do individual differences in midlife adiposity and APOE genotype as risk factors for dementia affect brain structure and cognition? A cross-sectional MRI study. Alzheimer’s Society and BRACE Fellowship. £305,161.

Metzler-Baddeley, C (PI), Jones, DK, Rosser AE. (2014) Effects of a novel intervention on white matter microstructure and cognition in Huntington’s disease. NISCHR and Welcome Trust ISSF project grant. £69,769.

Research group

CUBRIC
Cognitive Neuroscience
Imaging Science

Research collaborators

  • Professor Derek Jones (Cardiff)
  • Professor David Linden (Cardiff)
  • Professor Anne Rosser (Cardiff)
  • Professor John Aggleton (Cardiff)
  • Dr Seralynne Vann (Cardiff)
  • Professor Monica Busse (Cardiff)
  • Dr John Evans (Cardiff)
  • Dr Rebecca Sims (Cardiff)
  • Dr Emma Kidd (Cardiff)
  • Fabrizio Fasano (Siemens)
  • Dr Elizabeth Coulthard (Bristol)
  • Dr Roland J Baddeley (Bristol)
  • Professor Karen Caeyenberghs (Deakin University, Australia)
  • Professor Michael O'Sullivan (University of Queensland, Australia)
  • Professor Fernando Maestu (University of Madrid, Spain)
  • Dr Michael Funke (University of Texas, USA)
  • Professor Derek Hamilton (University of New Mexico, USA)

Media

  • What does CUBRIC mean to you? https://youtu.be/1OB2krtm434
  • Good evening Wales, BBC Radio Wales (11/12/2018)
  • ITV Wales (23/04/18).
  • BBC Wales  http://www.bbc.co.uk/news/uk-wales-36286847,
  • Guardian  - https://www.theguardian.com/science/2016/aug/04/brains-of-overweight-people-look-ten-years-older-than-those-of-lean-peers (4/08/16)
  • Panorama programme “Living with Dementia – Chris’ story broadcasted on BBC One (2/06/16).
  • Pint of Science Event Cardiff on brain plasticity (11/05/18)
  • BBC documentation on Terry Pratchett Living with Alzheimer’s, broadcast February 2009 https://www.bbc.co.uk/programmes/b00hhgsb
  • BBC Radio 4 Memory Experience.

Teaching

I lecture on the BSc Psychology Year 1 modules Introduction to Psychology (PS1016), the Year 3 module Memory Processes and Disorders (PS3208), and MSc Topics in Psychology (PST720).

Biography

Undergraduate education

Psychology at Bonn University, Germany

Postgraduate education

D.Phil work on frontal attention deficits at Sussex University

Employment

NIHR/HCRW Advanced Research Fellow (2022-2025)

Reader in Cognitive Neuroscience, Cardiff University (2020-present)

Senior Lecturer, Cardiff University (2016-2020)

Alzheimer’s Society and BRACE Research Fellow (2014-2018)

Research Associate, Cardiff University (2009-2014)

Neuropsychologist at the Research Institute for the Care of Older People (RICE) in Bath (2005-2009)

Lectureship in Psychology at Manchester University and postdoctoral work at the Institute of Psychiatry, King’s College London

Honours and awards

Awards/External Committees

Chartered Psychologist (CPsychol) and Associate Fellow of British Psychological Society (AFBPsS).

Member of Scientific Advisory Board, BRACE Alzheimer's charity

Member of UKRI BBSRC Ageing Across the Lifecourse Working Group

Member of editorial board for Scientific Reports (NPG)

Professional memberships

Society for Neuroscience (SfN)

Cognitive Neuroscience Society (CNS)

Organisation of Human Brain Mapping (OHBM)

International Society for Magnetic Resonance in Medicine (ISMRM)

Supervisions

Post-doctoral research associate: Vasilis Ioakeimidis (funded by NIHR/HCRW Advanced Fellowship)

Current PhD students research brain plasticity in ageing: Lucy Layland (School of Psychology Open PhD studentship 2022-2025), Fionnuala Rogers (School of Psychology Open PhD studentship 2021-2024)

Previous PhD students: Chiara Casella, Lauren Revie, Jilu Mole, Kat Christiansen