Yr Athro Krish Singh
(e/fe)

BSc Dunelm, PhD Open

: Ar gael fel goruchwyliwr ôl-raddedig

Timau a rolau for Krish Singh

Athro, Pennaeth Electroffisioleg Dynol
Yr Ysgol Seicoleg

Ymchwil - Cliciwch ar y tab ymchwil uchod am fwy o fanylion!

Mae fy ymchwil yn defnyddio delweddu anfewnwthiol o'r ymennydd dynol gan ddefnyddio delweddu cyseiniant magnetig (MRI) a Magnetoencephalography (MEG).

Yn wreiddiol o gefndir Ffiseg, rydw i bellach yn Niwrowyddonydd - yn gweithio ar y rhyngwyneb rhwng datblygiad methodolegol a chymwysiadau niwrowyddoniaeth glinigol a gwybyddol.

Cyrhaeddais Gaerdydd yn 2005 i helpu i arwain Canolfan Delweddu Ymchwil yr Ymennydd newydd Prifysgol Caerdydd (CUBRIC). Yma, fy mhrif rôl yw hwyluso ymchwil niwrodelweddu amlfoddol mewn cymwysiadau gwybyddol a chlinigol, gyda chylch gwaith penodol i hyrwyddo ymchwil electroffisioleg ddynol anfewnwthiol gan ddefnyddio EEG a MEG. Fel rhan o hyn, rwyf wedi helpu i adeiladu cydweithrediadau ymchwil trawsddisgyblaethol ar draws Prifysgol Caerdydd, gan gynnwys gyda chydweithwyr yn yr Ysgolion Meddygaeth a Biowyddorau, o fewn Sefydliad Arloesi Niwrowyddoniaeth ac Iechyd Meddwl Caerdydd. Mae hyn wedi arwain at raglenni ymchwil ar y cyd mewn Epilepsi, Sgitsoffrenia a chlefyd Alzheimer, gan gynnwys astudiaethau o farcwyr electroffisiolegol risg genetig.

Rwyf hefyd yn helpu i adeiladu a chynnal cymuned wyddonol MEG cydweithredol iawn y DU, trwy ein Partneriaeth MEG-UK. Yn ddiweddar, arweiniais grant Partneriaeth a ariennir gan MRC a gysylltodd holl grwpiau ymchwil MEG y DU gyda'i gilydd wrth ddatblygu dulliau hyfforddi, caffael a dadansoddi cyffredin ar gyfer ymchwil MEG, yn ogystal â chreu cronfa ddata aml-blatfform aml-safle o ddata MEG.

Crynodeb addysgu

Rwy'n arweinydd Modiwl ar gyfer modiwl Israddedig blwyddyn olaf, PS3214: "Cyflwyniad i Dulliau a Chymwysiadau Niwroddelweddu". Mae hwn yn gwrs sydd wedi'i gynllunio i roi mewnwelediad i fyfyrwyr i'r egwyddorion y tu ôl i dechnegau niwrodelweddu anfewnwthiol modern a'u cymhwyso mewn niwrowyddoniaeth wybyddol a chlinigol. Mae'r pynciau a drafodir yn cynnwys: Egwyddorion MRI a delweddu strwythurol, DTI, fMRI, TMS, TDCS, niwroffisioleg, EEG a MEG, seicosis, iselder, dementia a niwroleg.

Date
Type

2025

Lucie-Read, M., Hodgetts, C. J., Lawrence, A. D., Evans, C. J., Singh, K. D., Umla-Runge, K. and Graham, K. S. 2025. Multimodal MEG and microstructure-MRI investigations of the human hippocampal scene network.. The Journal of Neuroscience, article number: e1700242025. (10.1523/JNEUROSCI.1700-24.2025)
Rhodes, N. et al. 2025. Measuring the neurodevelopmental trajectory of excitatory-inhibitory balance via visual gamma oscillations. Imaging Neuroscience 3, article number: 00527. (10.1162/imag_a_00527)

2020

Perry, G., Taylor, N. W., Bothwell, P. C. H., Milbourn, C. C., Powell, G. and Singh, K. D. 2020. The gamma response to colour hue in humans: evidence from MEG. PLoS ONE 15(12), article number: e0243237. (10.1371/journal.pone.0243237)
Alamian, G., Pascarella, A., Tarek, L., Knight, L., Walters, J., Singh, K. D. and Jerbi, K. 2020. Patient, interrupted: MEG oscillation dynamics reveal temporal dysconnectivity in schizophrenia. NeuroImage: Clinical 28, article number: 102485. (10.1016/j.nicl.2020.102485)
Shaw, A. D., Muthukumaraswamy, S. D., Saxena, N., Sumner, R. L., Adams, N., Moran, R. J. and Singh, K. D. 2020. Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. NeuroImage 221, article number: 117189. (10.1016/j.neuroimage.2020.117189)
Dima, D. C. et al. 2020. Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk. Translational Psychiatry 10, article number: 324. (10.1038/s41398-020-00998-w)
Routley, B., Shaw, A., Muthukumaraswamy, S., Singh, K. and Hamandi, K. 2020. Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity. Epilepsy Research 163, article number: 106324. (10.1016/j.eplepsyres.2020.106324)
Shaw, A. D., Chandler, H. L., Hamandi, K., Muthukumaraswamy, S. D., Hammers, A. and Singh, K. D. 2020. GABAA receptor mapping in human using non-invasive electrophysiology. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2020.05.11.087726
Krzeminski, D., Masuda, N., Hamandi, K., Singh, K. D., Routley, B. and Zhang, J. 2020. Energy landscape of resting magnetoencephalography reveals frontoparietal network impairments in epilepsy. Network Neuroscience 4(2), pp. 374-396. (10.1162/netn_a_00125)

2019

Shaw, A. D. et al. 2019. Oscillatory, computational and behavioural evidence for impaired GABAergic inhibition in schizophrenia. Schizophrenia Bulletin 46(2), pp. 345-353. (10.1093/schbul/sbz066)
Koelewijn, L. et al. 2019. Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer's disease. eLife 8, article number: e36011. (10.7554/eLife.36011)
Stickland, R., Allen, M., Magazzini, L., Singh, K. D., Wise, R. G. and Tomassini, V. 2019. Neurovascular coupling during visual stimulation in Multiple Sclerosis: a MEG-fMRI study. Neuroscience 403, pp. 54-69. (10.1016/j.neuroscience.2018.03.018)
Lancaster, T. M. et al. 2019. Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype-based approach. Schizophrenia Bulletin 45(2), pp. 405-414. (10.1093/schbul/sby037)
Puts, N., Edden, R. A., Muthukumaraswamy, S., Singh, K. and McGonigle, D. 2019. Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex. Neural Plasticity 2019, article number: 5464096. (10.1155/2019/5464096)

2018

Dimitriadis, S., Brindley, L., Evans, L., Linden, D. E. J. and Singh, K. D. 2018. A novel, fast, reliable and data-driven method for simultaneous single-trial mining and amplitude - latency estimation based on proximity graphs and network analysis. Frontiers in Neuroinformatics 12, article number: 59. (10.3389/fninf.2018.00059)
Dima, D. C., Perry, G., Messaritaki, E., Zhang, J. and Singh, K. D. 2018. Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces. Human Brain Mapping 39(10), pp. 3993-4006. (10.1002/hbm.24226)
Dima, D., Perry, G. and Singh, K. 2018. Spatial frequency supports the emergence of categorical representations in visual cortex during natural scene perception. NeuroImage 179, pp. 102-116. (10.1016/j.neuroimage.2018.06.033)
Dimitriadis, S., Routley, B., Linden, D. and Singh, K. 2018. Reliability of static and dynamic network metrics in the resting-state: a MEG-beamformed connectivity analysis. Frontiers in Neuroscience 12, article number: 506. (10.3389/fnins.2018.00506)
Sumner, R. L., McMilllan, R. L., Shaw, A. D., Singh, K. D., Sundram, F. and Muthukumaraswamy, S. D. 2018. Peak visual gamma frequency is modified across the healthy menstrual cycle. Human Brain Mapping 39(8), pp. 3187-3202. (10.1002/hbm.24069)
Allen, C., Singh, K. D., Verbruggen, F. and Chambers, C. D. 2018. Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study. Royal Society Open Science 5(2), article number: 171369. (10.1098/rsos.171369)
Magazzini, L. and Singh, K. . D. 2018. Spatial attention modulates visual gamma oscillations across the human ventral stream. NeuroImage 166, pp. 219-229. (10.1016/j.neuroimage.2017.10.069)

2017

Routley, B., Singh, K., Khalid, H. and Muthukumaraswamy, S. D. 2017. The effects of AMPA receptor blockade on resting magnetoencephalography recordings. Journal of Psychopharmacology 31(12), pp. 1527-1536. (10.1177/0269881117736915)
Koelewijn, L., Bompas, A., Tales, A., Brookes, M. J., Muthukumaraswamy, S. D., Bayer, A. and Singh, K. D. 2017. Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity. Clinical Neurophysiology 128(11), pp. 2347-2357. (10.1016/j.clinph.2017.04.018)
Shaw, A. D., Moran, R. J., Muthukumaraswamy, S. D., Brealy, J., Linden, D. E., Friston, K. J. and Singh, K. D. 2017. Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma. NeuroImage 161, pp. 19-31. (10.1016/j.neuroimage.2017.08.034)
Messaritaki, E., Koelewijn, L., Dima, D., Williams, G., Perry, G. and Singh, K. 2017. Assessment and elimination of the effects of head movement on MEG resting-state measures of oscillatory brain activity. NeuroImage 159, pp. 302-324. (10.1016/j.neuroimage.2017.07.038)
Kirby, A. et al. 2017. Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder. Epilepsy & Behavior 72, pp. 122-126. (10.1016/j.yebeh.2017.04.014)
Uhlhaas, P. J., Liddle, P., Linden, D. E. J., Nobre, A. C., Singh, K. D. and Gross, J. 2017. Magnetoencephalography as a tool in psychiatric research: current status and perspective. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2(3), pp. 235-244. (10.1016/j.bpsc.2017.01.005)

2016

Pinotsis, D. A., Perry, G., Litvak, V., Singh, K. D. and Firston, K. 2016. Intersubject variability and induced gamma in the visual cortex: DCM with empirical bayes and neural fields. Human Brain Mapping 37(12), pp. 4597-4614. (10.1002/hbm.23331)
Magazzini, L. et al. 2016. Significant reductions in human visual gamma frequency by the GABA reuptake inhibitor tiagabine revealed by robust peak frequency estimation. Human Brain Mapping 37(11), pp. 3882-3896. (10.1002/hbm.23283)
Hunt, B. A. E. et al. 2016. Relationships between cortical myeloarchitecture and electrophysiological networks. Proceedings of the National Academy of Sciences 113(47), pp. 13510-13515. (10.1073/pnas.1608587113)
Mikkelsen, M., Singh, K., Brealy, J., Linden, D. and Evans, C. J. 2016. Quantification of y-aminobutyric acid (GABA) in 1 H MRS volumes composed heterogeneously of grey and white matter. NMR in Biomedicine 29(11), pp. 1644-1655. (10.1002/nbm.3622)
Hanley, C. J., Singh, K. D. and McGonigle, D. J. 2016. Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation. NeuroImage 140, pp. 20-32. (10.1016/j.neuroimage.2015.12.021)
Hamandi, K., Robson, S. E., Zaben, M., Singh, K. D. and Gray, W. P. 2016. Retinotopic fMRI and tumour resection in a case with occipital lobe epilepsy. Seizure - European Journal of Epilepsy 41, pp. 175-178. (10.1016/j.seizure.2016.08.006)
Muthukumaraswamy, S. D., Routley, B., Droog, W., Singh, K. D. and Hamandi, K. 2016. The effects of AMPA blockade on the spectral profile of human early visual cortex recordings studied with non-invasive MEG. Cortex 81, pp. 266-275. (10.1016/j.cortex.2016.03.004)
Carhart-Harris, R. L. et al. 2016. Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences 113(17), pp. 4853-4858. (10.1073/pnas.1518377113)
Mikkelsen, M., Singh, K. D., Sumner, P. and Evans, C. J. 2016. Comparison of the repeatability of GABA-edited magnetic resonance spectroscopy with and without macromolecule suppression. Magnetic Resonance in Medicine 75(3), pp. 946-953. (10.1002/mrm.25699)
Hamandi, K., Routley, B. C., Koelewijn, L. and Singh, K. D. 2016. Non-invasive brain mapping in epilepsy: applications from magnetoencephalography. Journal of Neuroscience Methods 260, pp. 283-291. (10.1016/j.jneumeth.2015.11.012)
Brindley, L. et al. 2016. Ipsilateral cortical motor desynchronisation is reduced in benign epilepsy with centro-temporal spikes. Clinical Neurophysiology 127(2), pp. 1147-1159. (10.1016/j.clinph.2015.08.020)
Dimitriadis, S., Linden, D. E. J., Singh, K. D. and Jones, D. K. 2016. A prolonged maturational time course in brain development for cortical processing of temporal modulations. Clinical Neurophysiology 127(2), pp. 994-998. (10.1016/j.clinph.2015.09.001)

2015

Dunkley, B. T., Freeman, T. C. A., Muthukumaraswamy, S. D. and Singh, K. D. 2015. Evidence that smooth pursuit velocity, not eye position, modulates alpha and beta oscillations in human middle temporal cortex. Human Brain Mapping 36(12), pp. 5220-5232. (10.1002/hbm.23006)
Koelewijn, L. et al. 2015. Resting-state oscillatory dynamics in sensorimotor cortex in benign epilepsy with centro-temporal spikes and typical brain development. Human Brain Mapping 36(10), pp. 3935-3949. (10.1002/hbm.22888)
Robson, S. E. et al. 2015. Structural and neurochemical correlates of individual differences in gamma frequency oscillations in human visual cortex. Journal of Anatomy 227(4), pp. 409-417. (10.1111/joa.12339)
Shaw, A. D., Saxena, N., Jackson, L. E., Hall, J. E., Singh, K. D. and Muthukumaraswamy, S. D. 2015. Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology 25(8), pp. 1136-1146. (10.1016/j.euroneuro.2015.04.012)
Perry, G., Randle, J., Koelewijn, L., Routley, B. C. and Singh, K. D. 2015. Linear tuning of gamma amplitude and frequency to luminance contrast: evidence from a continuous mapping paradigm. PLoS ONE 10(4), article number: e0124798. (10.1371/journal.pone.0124798)
Brealy, J., Shaw, A., Richardson, H., Singh, K. D., Muthukumaraswamy, S. and Keedwell, P. A. 2015. Increased visual gamma power in schizoaffective bipolar disorder. Psychological Medicine -London- 45(4), pp. 783-794. (10.1017/S0033291714001846)
Bompas, A., Sumner, P., Muthumumaraswamy, S. D., Singh, K. D. and Gilchrist, I. D. 2015. The contribution of pre-stimulus neural oscillatory activity to spontaneous response time variability. NeuroImage 107, pp. 34-45. (10.1016/j.neuroimage.2014.11.057)
Hinton, E. C., Wise, R. G., Singh, K. D. and Von Hecker, U. 2015. Reasoning with linear orders: Differential parietal cortex activation in sub-clinical depression. An fMRI investigation in sub-clinical depression and controls. Frontiers in Human Neuroscience 8, article number: 1061. (10.3389/fnhum.2014.01061)

2014

Campbell, A., Sumner, P., Singh, K. D. and Muthukumaraswamy, S. D. 2014. Acute effects of alcohol on stimulus-induced gamma oscillations in human primary visual and motor cortices. Neuropsychopharmacology -New York- 39(9), pp. 2104-2113. (10.1038/npp.2014.58)
Perry, G., Brindley, L., Muthukumaraswamy, S. D., Singh, K. D. and Hamandi, K. 2014. Evidence for increased visual gamma responses in photosensitive epilepsy. Epilepsy Research 108(6), pp. 1076-1086. (10.1016/j.eplepsyres.2014.04.012)
Mundy, M. E., Downing, P. E., Honey, R. C., Singh, K. D., Graham, K. S. and Dwyer, D. M. 2014. Brain correlates of experience-dependent changes in stimulus discrimination based on the amount and schedule of exposure. PLoS ONE 9(6), article number: e101011. (10.1371/journal.pone.0101011)
Allen, C. et al. 2014. Enhanced awareness followed reversible inhibition of human visual cortex: a combined TMS, MRS and MEG study. PLoS ONE 9(6), pp. e100350. (10.1371/journal.pone.0100350)
Dymond, S. et al. 2014. Almost winning: Induced MEG theta power in insula and orbitofrontal cortex increases during gambling near-misses and is associated with BOLD signal and gambling severity. NeuroImage 91, pp. 210-219. (10.1016/j.neuroimage.2014.01.019)
Perry, G. and Singh, K. 2014. Localizing evoked and induced responses to faces using magnetoencephalography. European Journal of Neuroscience 39(9), pp. 1517-1527. (10.1111/ejn.12520)

2013

Koelewijn, L., Rich, A. N., Muthukumaraswamy, S. D. and Singh, K. D. 2013. Spatial attention increases high-frequency gamma synchronisation in human medial visual cortex. NeuroImage 79, pp. 295-303. (10.1016/j.neuroimage.2013.04.108)
Muthukumaraswamy, S. D. et al. 2013. Broadband cortical desynchronization underlies the human psychedelic state. Journal of Neuroscience 33(38), pp. 15171-15183. (10.1523/JNEUROSCI.2063-13.2013)
Muthukumaraswamy, S. D., Myers, J., Wilson, S. J., Nutt, D. J., Hamandi, K., Lingford-Hughes, A. and Singh, K. D. 2013. Elevating endogenous GABA levels with GAT-1 blockade modulates evoked but not induced responses in human visual cortex. Neuropsychopharmacology 38(6), pp. 1105-1112. (10.1038/npp.2013.9)
Dunkley, B. T., Freeman, T. C. A., Muthukumaraswamy, S. D. and Singh, K. D. 2013. Cortical oscillatory changes in human middle temporal cortex underlying smooth pursuit eye movements. Human Brain Mapping 34(4), pp. 837-851. (10.1002/hbm.21478)
Shaw, A. et al. 2013. Marked reductions in visual evoked responses but not y-aminobutyric acid concentrations or y-band measures in remitted depression. Biological Psychiatry 73(7), pp. 691-698. (10.1016/j.biopsych.2012.09.032)
Muthukumaraswamy, S. D. and Singh, K. D. 2013. Visual gamma oscillations: The effects of stimulus type, visual field coverage and stimulus motion on MEG and EEG recordings. NeuroImage 69, pp. 223-230. (10.1016/j.neuroimage.2012.12.038)
Perry, G., Hamandi, K., Brindley, L., Muthukumaraswamy, S. D. and Singh, K. D. 2013. The properties of induced gamma oscillations in human visual cortex show individual variability in their dependence on stimulus size. Neuroimage 68, pp. 83-92. (10.1016/j.neuroimage.2012.11.043)
Saxena, N., Muthukumaraswamy, S. D., Diukova, A., Singh, K. D., Hall, J. E. and Wise, R. G. 2013. Enhanced stimulus-induced gamma activity in humans during propofol-induced sedation. PLoS ONE 8(3), article number: e57685. (10.1371/journal.pone.0057685)
Muthukumaraswamy, S., Myers, J. F. M., Wilson, S. J., Nutt, D. J., Lingford-Hughes, A., Singh, K. D. and Hamandi, K. 2013. The effects of elevated endogenous GABA levels on movement-related network oscillations. Neuroimage 66, pp. 36-41. (10.1016/j.neuroimage.2012.10.054)
Evans, C. J. et al. 2013. Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing. Journal of Magnetic Resonance Imaging 38(4), pp. 970-975. (10.1002/jmri.23923)
Swettenham, J., Muthukumaraswamy, S. D. and Singh, K. D. 2013. BOLD responses in human primary visual cortex are insensitive to substantial changes in neural activity. Frontiers in Human Neuroscience 7, article number: 76. (10.3389/fnhum.2013.00076)

2012

Gaetz, W., Roberts, T. P., Singh, K. D. and Muthukumaraswamy, S. D. 2012. Functional and structural correlates of the aging brain: Relating visual cortex (V1) gamma band responses to age-related structural change. Human Brain Mapping 33(9), pp. 2035-2046. (10.1002/hbm.21339)
Fan, Z., Muthukumaraswamy, S. D., Singh, K. D. and Shapiro, K. 2012. The role of sustained posterior brain activity in the serial chaining of two cognitive operations: A MEG study. Psychophysiology 49(8), pp. 1133-1144. (10.1111/j.1469-8986.2012.01391.x)
Singh, K. D. 2012. Which "neural activity" do you mean? fMRI, MEG, oscillations and neurotransmitters. NeuroImage 62(2), pp. 1121-1130. (10.1016/j.neuroimage.2012.01.028)
Muthukumaraswamy, S. D., Evans, C. J., Edden, R. A. E., Wise, R. G. and Singh, K. D. 2012. Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition. Human Brain Mapping 33(2), pp. 455-465. (10.1002/hbm.21223)
Fan, Z., Singh, K. D., Muthukumaraswamy, S. D., Sigman, M., Dehaene, S. and Shapiro, K. 2012. The cost of serially chaining two cognitive operations. Psychological Research 76(5), pp. 566-578. (10.1007/s00426-011-0375-y)

2011

Morgan, H. M., Muthukumaraswamy, S. D., Hibbs, C. S., Shapiro, K. L., Bracewell, R. M., Singh, K. D. and Linden, D. E. J. 2011. Feature integration in visual working memory: parietal gamma activity is related to cognitive coordination. Journal of Neurophysiology 106(6), pp. 3185-3194. (10.1152/jn.00246.2011)
Kennedy, J. S., Singh, K. D. and Muthukumaraswamy, S. D. 2011. An MEG investigation of the neural mechanisms subserving complex visuomotor coordination. International Journal of Psychophysiology 79(2), pp. 296-304. (10.1016/j.ijpsycho.2010.11.003)
Hamandi, K., Singh, K. D. and Muthukumaraswamy, S. D. 2011. Reduced movement-related beta desynchronisation in juvenile myoclonic epilepsy: A MEG study of task specific cortical modulation. Clinical Neurophysiology 122(11), pp. 2128-2138. (10.1016/j.clinph.2011.04.017)
Koelewijn, L., Dumont, J. R., Muthukumaraswamy, S. D., Rich, A. N. and Singh, K. D. 2011. Induced and evoked neural correlates of orientation selectivity in human visual cortex. NeuroImage 54(4), pp. 2983-2993. (10.1016/j.neuroimage.2010.11.045)
Muthukumaraswamy, S. D. and Singh, K. D. 2011. A cautionary note on the interpretation of phase-locking estimates with concurrent changes in power. Clinical Neurophysiology 122(11), pp. 2324-2325. (10.1016/j.clinph.2011.04.003)
Boy, F., Evans, C. J., Edden, R. A. E., Lawrence, A. D., Husain, M., Singh, K. D. and Sumner, P. 2011. Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity. Biological Psychiatry 70(9), pp. 866-872. (10.1016/j.biopsych.2011.05.030)
Sheppard, A. L., Evans, C. J., Singh, K. D., Wolffsohn, J. S., Dunne, M. C. M. and Davies, L. N. 2011. Three-Dimensional Magnetic Resonance Imaging of the Phakic Crystalline Lens during Accommodation. Investigative Ophthalmology & Visual Science 52(6), pp. 3689-3697. (10.1167/iovs.10-6805)

2010

Boy, F., Evans, C. J., Edden, R. A. E., Singh, K. D., Husain, M. and Sumner, P. 2010. Individual differences in subconscious motor control predicted by GABA concentration in SMA. Current Biology 20(19), pp. 1779-1785. (10.1016/j.cub.2010.09.003)
Sumner, P., Edden, R. A. E., Bompas, A., Evans, C. J. and Singh, K. D. 2010. More GABA, less distraction: a neurochemical predictor of motor decision speed. Nature Neuroscience 13(7), pp. 825-827. (10.1038/nn.2559)
Muthukumaraswamy, S. D., Singh, K. D., Swettenham, J. B. and Jones, D. K. 2010. Visual gamma oscillations and evoked responses: Variability, repeatability and structural MRI correlates. NeuroImage 49(4), pp. 3349-3357. (10.1016/j.neuroimage.2009.11.045)
Tattersall, R. J., Prashar, A., Singh, K. D., Tokarczuk, P. F., Erichsen, J. T., Hocking, P. M. and Guggenheim, J. A. 2010. Ex vivo magnetic resonance imaging of crystalline lens dimensions in chicken. Molecular Vision 16(18), pp. 144-153.
Barnes, G. R., Li, X., Thompson, B., Singh, K. D., Dumoulin, S. O. and Hess, R. F. 2010. Decreased Gray Matter Concentration in the Lateral Geniculate Nuclei in Human Amblyopes. Investigative Ophthalmology & Visual Science 51(3), pp. 1432-1438. (10.1167/iovs.09-3931)
Boy, F., Husain, M., Singh, K. D. and Sumner, P. 2010. Supplementary motor area activations in unconscious inhibition of voluntary action. Experimental Brain Research 206(4), pp. 441-448. (10.1007/s00221-010-2417-x)

2009

Edden, R. A. E., Muthukumaraswamy, S. D., Freeman, T. C. A. and Singh, K. D. 2009. Orientation discrimination performance is predicted by GABA concentration and gamma oscillation frequency in human primary visual cortex. The Journal of Neuroscience 29(50), pp. 15721-15726. (10.1523/JNEUROSCI.4426-09.2009)
Swettenham, J. B., Muthukumaraswamy, S. D. and Singh, K. D. 2009. Spectral properties of induced and evoked gamma oscillations in human early visual cortex to moving and stationary stimuli. Journal of Neurophysiology 102(2), pp. 1241-1253. (10.1152/jn.91044.2008)
Muthukumaraswamy, S. D. and Singh, K. D. 2009. Functional decoupling of BOLD and gamma-band amplitudes in human primary visual cortex. Human Brain Mapping 30(7), pp. 2000-2007. (10.1002/hbm.20644)
Muthukumaraswamy, S. D., Edden, R. A. E., Jones, D. K., Swettenham, J. B. and Singh, K. D. 2009. Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Proceedings of the National Academy of Sciences of the United States of America 106(20), pp. 8356-8361. (10.1073/pnas.0900728106)
Goodall, N. et al. 2009. 3-Dimensional modelling of chick embryo eye development and growth using high resolution magnetic resonance imaging. Experimental Eye Research 89(4), pp. 511-521. (10.1016/j.exer.2009.05.014)
Bridson, N. C., Muthukumaraswamy, S. D., Singh, K. D. and Wilding, E. L. 2009. Magnetoencephalographic correlates of processes supporting long-term memory judgments. Brain Research 1283, pp. 73-83. (10.1016/j.brainres.2009.05.093)
Simpson, M. I. G., Barnes, G. R., Johnson, S. R., Hillebrand, A., Singh, K. D. and Green, G. G. R. 2009. MEG evidence that the central auditory system simultaneously encodes multiple temporal cues. European Journal of Neuroscience 30(6), pp. 1183-1191. (10.1111/j.1460-9568.2009.06900.x)

2008

Singh, K. D. and Fawcett, I. P. 2008. Transient and linearly graded deactivation of the human default-mode network by a visual detection task. NeuroImage 41(1), pp. 100-112. (10.1016/j.neuroimage.2008.01.051)
Muthukumaraswamy, S. D. and Singh, K. D. 2008. Spatiotemporal frequency tuning of BOLD and gamma band MEG responses compared in primary visual cortex. NeuroImage 40(4), pp. 1552-1560. (10.1016/j.neuroimage.2008.01.052)
Muthukumaraswamy, S. D. and Singh, K. D. 2008. Modulation of the human mirror neuron system during cognitive activity. Psychophysiology 45(6), pp. 896-905. (10.1111/j.1469-8986.2008.00711.x)

2007

Henson, R., Mattout, J., Singh, K. D., Barnes, G., Hillebrand, A. and Friston, K. 2007. Population-level inferences for distributed MEG source localization under multiple constraints: Application to face-evoked fields. Neuroimage 38(3), pp. 422-438. (10.1016/j.neuroimage.2007.07.026)
Maratos, F. A., Anderson, S. J., Hillebrand, A., Singh, K. D. and Barnes, G. R. 2007. The spatial distribution and temporal dynamics of brain regions activated during the perception of object and non-object patterns. Neuroimage 34(1), pp. 371-383. (10.1016/j.neuroimage.2006.09.017)
Fawcett, I. P., Hillebrand, A. and Singh, K. D. 2007. The temporal sequence of evoked and induced cortical responses to implied-motion processing in human motion area V5/MT+. European Journal of Neuroscience 26(3), pp. 775-783. (10.1111/j.1460-9568.2007.05707.x)
Herrington, J. D., Baron-Cohen, S., Wheelwright, S. J., Singh, K. D., Bullmore, E. T., Brammer, M. and Williams, S. C. R. 2007. The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study. Research in Autism Spectrum Disorders 1(1), pp. 14-27. (10.1016/j.rasd.2006.07.002)
Smith, A. T., Singh, K. D. and Balsters, J. H. 2007. A comment on the severity of the effects of non-white noise in fMRI time-series. NeuroImage 36(2), pp. 282-288. (10.1016/j.neuroimage.2006.09.044)
McNab, F., Rippon, G., Hillebrand, A., Singh, K. D. and Swithenby, S. J. 2007. Semantic and phonological task-set priming and stimulus processing investigated using magnetoencephalography (MEG). Neuropsychologia 45(5), pp. 1041-1054. (10.1016/j.neuropsychologia.2006.09.008)

2006

Barnes, G. R., Furlong, P. L., Singh, K. D. and Hillebrand, A. 2006. A verifiable solution to the MEG inverse problem. Neuroimage 31(2), pp. 623-626. (10.1016/j.neuroimage.2005.12.036)
Smith, A. T., Wall, M. B., Williams, A. L. and Singh, K. D. 2006. Sensitivity to optic flow in human cortical areas MT and MST. European Journal of Neuroscience 23(2), pp. 561-569. (10.1111/j.1460-9568.2005.04526.x)
Singh, K. D., Logan, N. S. and Gilmartin, B. 2006. Three-Dimensional Modeling of the Human Eye Based on Magnetic Resonance Imaging. Investigative Ophthalmology & Visual Science 47(6), pp. 2272-2279. (10.1167/iovs.05-0856)

2005

Hall, S. D., Holliday, I. E., Hillebrand, A., Furlong, P. L., Singh, K. D. and Barnes, G. R. 2005. Distinct contrast response functions in striate and extra-striate regions of visual cortex revealed with magnetoencephalography (MEG). Clinical Neurophysiology 116(7), pp. 1716-1722. (10.1016/j.clinph.2005.02.027)
Hadjipapas, A., Hillebrand, A., Holliday, I. E., Singh, K. D. and Barnes, G. R. 2005. Assessing interactions of linear and nonlinear neuronal sources using MEG beamformers: a proof of concept. Clinical Neurophysiology 116(6), pp. 1300-1313. (10.1016/j.clinph.2005.01.014)
Brookes, M. J. et al. 2005. GLM-beamformer method demonstrates stationary field, alpha ERD and gamma ERS co-localisation with fMRI BOLD response in visual cortex. NeuroImage 26(1), pp. 302-308. (10.1016/j.neuroimage.2005.01.050)
Hall, S. D., Holliday, I. E., Hillebrand, A., Singh, K. D., Furlong, P. L., Hadjipapas, A. and Barnes, G. R. 2005. The missing link: analogous human and primate cortical gamma oscillations. Neuroimage 26(1), pp. 13-17. (10.1016/j.neuroimage.2005.01.009)
Hillebrand, A., Singh, K. D., Holliday, I. E., Furlong, P. L. and Barnes, G. R. 2005. A new approach to neuroimaging with magnetoencephalography. Human Brain Mapping 25(2), pp. 199-211. (10.1002/hbm.20102)
Hobson, A. R., Furlong, P. L., Worthen, S. F., Hillebrand, A., Barnes, G. R., Singh, K. D. and Aziz, Q. 2005. Real-time imaging of human cortical activity evoked by painful esophageal stimulation. Gastroenterology 128(3), pp. 610-619. (10.1053/j.gastro.2004.12.033)

2004

Brookes, M. J. et al. 2004. A general linear model for MEG beamformer imaging. Neuroimage 23(3), pp. 936-946. (10.1016/j.neuroimage.2004.06.031)
Barnes, G. R., Hillebrand, A., Fawcett, I. P. and Singh, K. D. 2004. Realistic spatial sampling for MEG beamformer images. Human Brain Mapping 23(2), pp. 120-127. (10.1002/hbm.20047)
Pammer, K. et al. 2004. Visual word recognition: the first half second. Neuroimage 22(4), pp. 1819-1825. (10.1016/j.neuroimage.2004.05.004)
Furlong, P. L. et al. 2004. Dissociating the spatio-temporal characteristics of cortical neuronal activity associated with human volitional swallowing in the healthy adult brain. Neuroimage 22(4), pp. 1447-1455. (10.1016/j.neuroimage.2004.02.041)
Adjamian, P., Holliday, I. E., Barnes, G. R., Hillebrand, A., Hadjipapas, A. and Singh, K. D. 2004. Induced visual illusions and gamma oscillations in human primary visual cortex. European Journal of Neuroscience 20(2), pp. 587-592. (10.1111/j.1460-9568.2004.03495.x)
Fawcett, I. P., Barnes, G. R., Hillebrand, A. and Singh, K. D. 2004. The temporal frequency tuning of visual cortex investigated using synthetic aperture magnetometry. NeuroImage 21(4), pp. 1542-1553. (10.1016/j.neuroimage.2003.10.045)
Smith, A. T., Williams, A. L. and Singh, K. D. 2004. Negative BOLD in the visual cortex: Evidence against blood stealing. Human Brain Mapping 21(4), pp. 213-220. (10.1002/hbm.20017)
Hall, S. D., Barnes, G. R., Hillebrand, A., Furlong, P. L., Singh, K. D. and Holliday, I. E. 2004. Spatio-temporal imaging of cortical desynchronization in migraine visual aura: A magnetoencephalography case study. Headache 44(3), pp. 204-208. (10.1111/j.1526-4610.2004.04048.x)
Adjamian, P. et al. 2004. Co-registration of magnetoencephalography with magnetic resonance imaging using bite-bar-based fiducials and surface-matching. Clinical Neurophysiology 115(3), pp. 691-698. (10.1016/j.clinph.2003.10.023)

2003

Holliday, I. E., Barnes, G. R., Hillebrand, A. and Singh, K. D. 2003. Accuracy and applications of group MEG studies using cortical source locations estimated from participants' scalp surfaces. Human Brain Mapping 20(3), pp. 142-147. (10.1002/hbm.10133)
Singh, K. D., Barnes, G. R. and Hillebrand, A. 2003. Group Imaging of task-related changes in cortical synchronisation using non-parametric permutation testing. NeuroImage 19(4), pp. 1589-1601. (10.1016/S1053-8119(03)00249-0)
Williams, A. L., Singh, K. D. and Smith, A. T. 2003. Surround modulation measured with functional MRI in the human visual cortex. Journal of Neurophysiology 89(1), pp. 525-533. (10.1152/jn.00048.2002)

2002

Singh, K. D., Barnes, G. R., Hillebrand, A., Forde, E. M. and WIlliams, A. L. 2002. Task-related changes in cortical synchronisation are spatially coincident with the hemodynamic response. NeuroImage 16(1), pp. 103-114. (10.1006/nimg.2001.1050)
Brooks, J. C. W., Nurmikko, T. J., Bimson, W. E., Singh, K. D. and Roberts, N. 2002. fMRI of thermal pain: Effects of stimulus laterality and attention. Neuroimage 15(2), pp. 293-301. (10.1006/nimg.2001.0974)

2001

Smith, A. T., Singh, K. D., Williams, A. L. and Greenlee, M. W. 2001. Estimating receptive field size from fMRI data in human striate and extrastriate visual cortex. Cerebral Cortex 11(12), pp. 1182-1190. (10.1093/cercor/11.12.1182)
Dickins, D. W., Singh, K. D., Roberts, N., Burns, P., Downes, J. J., Jimmieson, P. and Bentall, R. P. 2001. An fMRI study of stimulus equivalence. Neuroreport 12(2), pp. 405-411.

2000

Singh, K. D., Smith, A. T. and Greenlee, M. W. 2000. Spatiotemporal frequency and direction sensitivities of human visual areas measured using fMRI. Neuroimage 12(5), pp. 550-564. (10.1006/nimg.2000.0642)
Smith, A., Scott-Samuel, N. E. and Singh, K. D. 2000. Global motion adaptation. Vision Research 40(9), pp. 1069-1075. (10.1016/S0042-6989(00)00014-6)
Smith, A. T., Singh, K. D. and Greenlee, M. W. 2000. Attentional suppression of activity in the human visual cortex. Neuroreport 11(2), pp. 271-277.

1999

Turnbull, G. K., Hamdy, S. E., Aziz, Q., Singh, K. D. and Thompson, D. G. 1999. The cortical topography of human anorectal musculature. Gastroenterology 117(1), pp. 32-39. (10.1016/S0016-5085(99)70547-0)

1998

Hamdy, S. et al. 1998. Recovery of swallowing after dysphagic stroke relates to functional reorganization in the intact motor cortex. Gastroenterology 115(5), pp. 1104-1112. (10.1016/S0016-5085(98)70081-2)
Bastings, E. P. et al. 1998. Co-registration of cortical magnetic stimulation and functional magnetic resonance imaging. Neuroreport 9(9), pp. 1941-1946.
Smith, A. T., Greenlee, M. W., Singh, K. D., Kraemer, F. M. and Hennig, J. 1998. The processing of first- and second-order motion in human visual cortex assessed by functional magnetic resonance imaging (fMRI). Journal of Neuroscience 18(10), pp. 3816-3830.
Hamdy, S., Rothwell, J. C., Aziz, Q., Singh, K. D. and Thompson, D. G. 1998. Long-term reorganization of human motor cortex driven by short-term sensory stimulation. Nature Neuroscience 1(1), pp. 64-68. (10.1038/264)
Furlong, P. L., Aziz, Q., Singh, K. D., Thompson, D. G., Hobson, A. and Harding, G. F. A. 1998. Cortical localisation of magnetic fields evoked by oesophageal distension. Electroencephalography and clinical neurophysiology. Evoked potentials 108(3), pp. 234-243. (10.1016/S0168-5597(98)00016-1)

1997

Singh, K. D., Hamdy, S., Aziz, Q. and Thompson, D. G. 1997. Topographic mapping of trans-cranial magnetic stimulation data on surface rendered MR images of the brain. Electroencephalography and clinical neurophysiology. Electromyography and motor control. 105(5), pp. 345-351. (10.1016/S0924-980X(97)96699-6)
Fylan, F., Holliday, I. E., Singh, K. D., Anderson, S. J. and Harding, G. F. A. 1997. Magnetoencephalographic investigation of human cortical area V1 using color stimuli. Neuroimage 6(1), pp. 47-57. (10.1006/nimg.1997.0273)
Singh, K. D., Holliday, I. E., Furlong, P. L. and Harding, G. F. A. 1997. Evaluation of MRI-MEG/EEG co-registration strategies using Monte Carlo simulation. Electroencephalography and clinical neurophysiology 102(2), pp. 81-85. (10.1016/S0921-884X(96)96570-4)

1996

Hamdy, S. et al. 1996. The cortical topography of human swallowing musculature in health and disease. Nature Medicine 2(11), pp. 1217-1224. (10.1038/nm1196-1217)
Anderson, S. J., Holliday, I. E., Singh, K. D. and Harding, G. F. A. 1996. Localization and functional analysis of human cortical area V5 using magneto-encephalography. Proceedings of the Royal Society: Series B Biological Sciences 263(1369), pp. 423-431. (10.1098/rspb.1996.0064)

1995

Singh, K. D. 1995. Functional imaging of the brain using superconducting magnetometry. Endeavour 19(1), pp. 39-44. (10.1016/0160-9327(95)98893-K)

1994

Singh, K. D. et al. 1994. Distributed current analyses of bi-hemispheric magnetic N1m responses to ipsi/contralateral monaural stimuli from a single subject. Electroencephalography and Clinical Neurophysiology/Evoked potentials 92(4), pp. 365-368. (10.1016/0168-5597(94)90104-X)

1993

Toannides, A. A., Singh, K. D., Hasson, R., Baumann, S. B., Rogers, R. L., Guinto, F. C. and Papanicolaou, A. C. 1993. Comparison of single current dipole and Magnetic Field Tomography analyses of the cortical response to auditory stimuli. Brain Topography 6(1), pp. 27-34. (10.1007/BF01234124)

1991

Ribary, U. et al. 1991. Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. Proceedings of the National Academy of Sciences of the United States of America 88(24), pp. 11037-11041.

Yn yr adrannau canlynol gallwch weld mwy o fanylion am fy ymchwil. Sgroliwch i lawr i weld:

Rhaglenni Ymchwil Cyfredol
Papurau Ymchwil Diweddar Allweddol
Dyfarniadau Cyllid, Ddoe a Heddiw

1. Rhaglenni Ymchwil Cyfredol

Astudiaethau sy'n dangos y gall Magnetoencephalography (MEG) ddarparu marcwyr sensitif a datrys amser o weithredu ffarmacolegol, gan alluogi mewnwelediadau mecanyddol a thystiolaeth electroffisiolegol o ymgysylltiad targed newydd mewn systemau derbynnydd lluosog: GABA (10.1002 / hbm.23283, 10.1016 / j.neuroimage.2017.08.034), AMPA (10.1177 / 0269881117736915, 10.1016 / j.cortex.2016.03.004) a NMDA (10.1016 / j.euroneuro.2015.04.012, 10.1016 / j.neuroimage.2020.117189).
Biomarcwyr osgiliadol mewn iechyd a chlefydau: Yn ddiweddar, rwyf wedi dod â diddordeb mewn defnyddio paramedrau osgiliadol wedi'u mesur gan MEG i helpu i nodweddu swyddogaeth synaptig mewn clefydau y credir eu bod yn dibynnu ar namau i'r systemau hyn, fel Sgitsoffrenia ac Epilepsi. Er enghraifft, ynghyd â chydweithwyr clinigol, fe wnaethom ddangos nam ar ddatsyncroneiddio beta arferol mewn cleifion ag epilepsi myoclonig ieuenctid (Hamandi et al., Niwroffisioleg Glinigol 2011, cyfrol 122(11)). Mewn astudiaeth MEG ddiweddar, dangoswyd bod cludwyr iach ifanc y genyn risg APOE4 yn dangos hyper-gysylltedd osgiliadol, a gor-weithgaredd ar draws y cortecs, mewn rhanbarthau tebyg i'r rhai a ddangosodd lai o gysylltedd mewn pobl hŷn â chlefyd Alzheimer sefydledig (eLife 2019; 8:e36011).
Yn ddiweddar, gyda chydweithwyr o'r Ysgol Feddygaeth, fe wnaethom ddangos sut roedd ymatebion gama gweledol yn cael eu gwahardd mewn Sgitsoffrenia cronig, ac y gallem gael mewnwelediad i sut y deilliodd y rhain o darfu ar y cyplu arferol o fewn / rhwng interneurons ataliol a chelloedd pyramidaidd - dulliau a fydd yn hanfodol bwysig yn y prosiect arfaethedig (Bwletin Sgitsoffrenia, SBZ066).
Astudiaethau fMRI a MEG o cortex gweledol dynol, gan gynnwys y berthynas rhwng yr ymateb haemodynamig a gweithgaredd osgiliadoliaeth cortical e.e. Singh et al., Neuroimage 2002, cyfrol 16.
Y defnydd o Sbectrosgopeg Cyseiniant Magnetig i asesu amrywioldeb mewn niwrodrosglwyddyddion (fel GABA) a sut mae hyn yn pennu dynameg a swyddogaeth osgiliadol (Muthukumaraswamy et al., PNAS 2009, cyfrol 106; Edden et al., J. Neurosci. 2009, cyfrol 29(50)).
Astudio sut mae amrywioldeb unigol yn strwythur a swyddogaeth yr ymennydd yn arwain at amrywioldeb mewn perfformiad canfyddiadol a gwybyddol: Er enghraifft, dangosom fod perfformiad ar wahaniaethu cyfeiriadedd gweledol yn gysylltiedig ag amrywioldeb unigol mewn crynodiad GABA ac amledd gama gweledol mewn bodau dynol iach. (Edden et al., J. Neurosci. 2009, cyfrol 29(50)).

2. Papurau Ymchwil Allweddol Diweddar

Dima DC, Adams R, Linden SC, Baird A, Smith J, Foley S, Perry G, Routley BC, Magazzini L, Drakesmith M, Williams N, Doherty J, van den Bree MBM, Owen MJ, Hall J, Linden DEJ, Singh KD (2020) Newidiadau rhwydwaith electroffisiolegol mewn oedolion ag amrywiadau rhif copi sy'n gysylltiedig â risg niwroddatblygiadol uchel. Seiciatreg Drosiadol10(1), 324 (PMCID: PMC7506525). Yn y papur MEG cyflwr gorffwys hwn, rydym yn dangos bod cysylltedd osgiliadol yn wahanol mewn pobl sy'n cario amrywiadau genetig prin, fel dileu 22q11, a bod dulliau dysgu peirianyddol yn caniatáu dosbarthu traws-grŵp. Mae'r canlyniadau'n dangos, er bod rhai nodweddion electroffisiolegol yn CNV-benodol, mae eraill yn adlewyrchu prosesau niwrobiolegol mwy cydgyfeiriol.
Shaw AD, Knight L, Freeman TCA, Williams GM, Moran, Friston KJ, Walters TR a Singh KD. (2020). Tystiolaeth osgiliadol, gyfrifiadurol ac ymddygiadol ar gyfer ataliad GABAergig nam mewn sgitsoffrenia, Bwletin Sgitsoffrenia, 46(2), 345-353. (PMCID: PMC7442335). Gan ddefnyddio MEG, sbectrosgopeg MR a seicoffiseg gweledol, rydym yn nodi sawl nodwedd ddata sy'n wahanol mewn sgitsoffrenia cronig, o'i gymharu â rheolaethau. Gall llawer o'r newidiadau hyn sy'n gysylltiedig â chlefydau mewn osgiliadau gama, GABA a gwahaniaethu cyfeiriadedd fod yn gysylltiedig â gostyngiadau mewn ataliad GABAergig - mae hyn yn cael ei wneud yn benodol trwy fodelu niwroffisiolegol (DCM).
Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD (2020). Modelu cynhyrchiol o'r mecanweithiau cylched thalamo-cortical sy'n sail i effeithiau niwroffisiolegol ketamine. Niwrodelwedd. 221:117189. (PMCID yn yr arfaeth). Rydym yn dangos sut y gall modelu DCM o ddata MEG lleol ffynhonnell, wedi'i fesur cyn ac yn ystod trwyth ketamine, ymchwilio i newidiadau cylched derbynnydd-benodol a achosir gan y gwrthwynebydd NMDA hwn. Gellir defnyddio ein model wedi'i optimeiddio mewn astudiaethau cyffuriau eraill a hefyd mewn astudiaethau carfan clefydau lle rhagdybir modiwliadau niwrodrosglwyddydd-benodol, megis namau NMDAR mewn Sgitsoffrenia neu risg genetig o Sgitsoffrenia.
Koelewijn L., Lancaster TM, Linden D., Dima DC, Routley BC, Magazzini L., Barawi K., Brindley L., Adams R., Tansey KE, Bompas A., Tales A., Bayer A., Singh KD (2019). Gorfywiogrwydd osgiliadol a gorgysylltedd mewn cludwyr APOE-e4 ifanc a hypoconnectivity mewn clefyd Alzheimer. eLife 2019; 8: e36011 (PMCID PMC6491037), 10.7554 / eLife.36011. Gan ddefnyddio MEG cyflwr gorffwys mewn cludwyr ifanc o APOE-e4, gwelsom orfywiogrwydd osgiliadol/hypergysylltedd o'i gymharu â di-gludwyr. Mae hyn yn gyson â data anifeiliaid sy'n dangos gorfywiogrwydd sy'n gysylltiedig ag amyloid-beta a throsglwyddo clefyd diweddarach. Mewn carfan hŷn, fe wnaethom hefyd nodi hypoconnectivity mewn pobl ag Alzheimer's. Mae hyn yn awgrymu marcwyr electroffisiolegol cynnar posibl o risg dementia a allai helpu i ddeall / rhagfynegi pontio diweddarach.
Shaw, AD, Moran, RJ, Muthukumaraswamy, SD, Brealy J., Linden DE, Friston, KJ, Singh, KD (2017). Marcwyr niwroffisiolegol o amrywioldeb unigol a thriniaeth ffarmacolegol gama cortical dynol. Niwro-ddelwedd. 161, tt. 19-31, (PMCID 5692925). Rydym yn dangos sut y gall modelu osgiliadau gamma cortecs gweledol wedi'u mesur gan MEG, gan ddefnyddio model cyfrifiadurol sy'n deillio o astudiaethau anifeiliaid o V1, ddarparu mewnwelediad i'r ffisioleg synaptig sy'n sail i amrywioldeb unigol dynol a tharged a dynameg cyffuriau sy'n targedu derbynyddion / niwrodrosglwyddyddion penodol.
Singh KD. Pa "weithgaredd niwral" ydych chi'n ei olygu? (2012) fMRI, MEG, osgiliadau a niwrodrosglwyddyddion. Niwrodelwedd, 62 (2): 1121-1130 (PMID 22248578). Yma, adolygais y berthynas rhwng fMRI-BOLD a mesurau electroffisiolegol uniongyrchol o MEG / EEG. Y syniad yw bod fMRI yn aml yn cael ei ddisgrifio fel mesur "gweithgaredd niwral" ond, mewn gwirionedd, mae'n gydberthynas o gymysgedd cymhleth o signalau electroffisiolegol sy'n gysylltiedig â chyffroi ac ataliad, sy'n cael ei ddeall yn wael a gall amrywio ar draws yr ymennydd a phobl.

3. Dyfarniadau Cyllido

$9.8M CAD (£865,000 i Gaerdydd) o Wellcome (2025-2030). DIALOG: Deall Disorganisation: Menter Fyd-eang sy'n canolbwyntio ar iaith mewn seicosis, (314138/Z/24/Z). Palaniyappan, Bambini, Harrison (cyd-PI Caerdydd), Kircher, Kuperberg, Rossell, Singh (cyd-PI Caerdydd), Sommer.
£500,000 (£245,000 i Gaerdydd) gan UKRI-STFC (2025-2027). Synwyryddion cwantwm ar gyfer modelu bioffisegol o swyddogaeth yr ymennydd (cwantwm DU-Canada ar gyfer cydweithredu ymchwil gwyddoniaeth). Brookes, Dunkley, Singh (Caerdydd PI), Taylor.
£2.5M gan UKRI-MRC (2022-2026). Effaith amrywiolion rhif copi sy'n gysylltiedig â sgitsoffrenia ar ddeinameg rhwydwaith cortical. Hall, Van den Bree, Singh, Wilkinson, Harwood, Jones, Friston.
£6.8M gan Ymddiriedolaeth Wellcome (2021-2024). Astudiaethau clinigol Cam 1 ar gyfer MDI-478: Modulator allosterig positif derbynnydd AMPA ar gyfer trin nam gwybyddol sy'n gysylltiedig â sgitsoffrenia. Ward, Singh, Atack, Harrison.
£572,131 gan Syndesi Therapeutics SA. (2021-2022). Grŵp cyfochrog Cam Ib, archwiliadol, dwbl ddall, a reolir gan placebo, o SDI-118 i werthuso diogelwch, goddefgarwch a ffarmacodynameg gan gynnwys swyddogaeth wybyddol mewn cyfranogwyr gwrywaidd a benywaidd mewn rhyddhad o iselder. Wilkinson, Singh, Drew, Murphy, Harrison.
£165,055, Grant Prosiect Endeavour gan Epilepsy Research UK. (2021-2024). Gweld y tu mewn: mapio ymennydd anfewnwthiol o weithgaredd epileptig (SINIMA). Hamandi, Singh, Murphy, Faulkner, Sieradzan.
£400,000 gan yr EPSRC. (2020-2021). Grant Offer Craidd. Graham, Singh (Cyd-PI), Murphy, Beltrachini, Holt, Lawrence, Charron.
£28678 gan yr EPSRC. (2017-2020). Ehangu cymwysiadau magnetoencephalograffeg gyda magnetomedrau wedi'u pwmpio optegol. Beltrachini, Singh.
£19,968 gan yr EPSRC. (2017-2020). Ap symudol dewin synhwyrydd. Beltrachini, Singh.
£47210 gan ISSF Ymddiriedolaeth Wellcome .( 2020-2021). Datblygu MEG gwisgadwy, tymheredd ystafell a symudiad ar gyfer oedolion a phlant ym Mhrifysgol Caerdydd. Singh, Beltrachini, Vanderwert.
£971,676 o'r MRC. (2018-2020). Integreiddio data genetig, clinigol a ffenoteipig i hyrwyddo haenu, rhagfynegi a thriniaeth mewn iechyd meddwl. Hall, Owen, Harwood, John, Murphy, Walters, O'Donovan, Atack, Jones, Rice, Holmans, Collishaw, Moore, Singh, Thapar.
£44,206 gan y Sefydliad Ymchwil i'r Ymennydd ac Ymddygiad. (2016-2019). Effaith amrywiolion prin sy'n effeithio ar GABA a setiau genynnau glutamad mewn sgitsoffrenia: Astudiaeth MEG, Walters, Singh, Williams.
£99,998 gan Fight For Sight. (2016-2021). Newidiadau yn y cortecs gweledol mewn glawcoma a'u rôl mewn adferiad gweledol: Astudiaeth seiliedig ar fMRI. Redmond a Singh.
£6.7miliwn o'r MRC. (2014-2016). Gwella Galluoedd a Thechnolegau Ymchwil Glinigol y DU 2014. MRI Maes Ultra-Uchel: Hyrwyddo Ymchwil Niwrowyddonol Clinigol mewn Meddygaeth Arbrofol. Wise, Jones, Singh, Linden, Kauppinen (Bryste), Graham.
£4.9miliwn gan Ymddiriedolaeth Wellcome. (2016-2021). Asesiad aml-raddfa ac aml-foddol o cyplu yn yr ymennydd iach a sâl. Jones, Assaf, Chambers, Graham, Jezzard (Rhydychen), Linden, Morris (Nottingham), Nutt (ICL), Sumner, Singh, Wise.
£2.9M gan yr EPSRC (2014-2019). Cyfleuster Cenedlaethol ar gyfer Delweddu MR In Vivo o Microstrwythur Meinwe Dynol. Jones, Alexander (UCL), Bowtell (Nottingham), Cercignani (Sussex), Dell'Acqua (KCL), Parker (Manceinion), Singh, Wise, Miller (Rhydychen), Thomas.
£1.0miliwn gan Sefydliad Wolfson (2014-2016). CUBRIC – Canolfan Delweddu Ymchwil yr Ymennydd Prifysgol Caerdydd. Singh, Price, Jones, Wise, Linden, Graham, Chambers, Sumner.
£4.9miliwn (FEC) (£654,159 i Gaerdydd) o'r MRC. (2014-2019). MICA: STRATA - Sgitsoffrenia: Ymwrthedd Triniaeth a Datblygiadau Therapiwtig. Kapur, McCabe, Murray, McGuire, Howes, Rose, McCrone, Pickles, Talbot, Williams, Matthews, Deakins, Lewis, Emsley, Stone, Walters, Owen, Pocklington, Singh, Lawrie, McIntosh, Egerton, Doody, O'Neill, O'Donovan.
£44569 gan ISSF Ymddiriedolaeth Wellcome (2017-2018). Nodweddu newidiadau o ddeinameg niwral mewn epilepsi anhygoel gan ddefnyddio modelau niwroffisiolegol gwybodus. Zhang, Singh, Hamandi, Cheng.
£38601 gan ISSF Ymddiriedolaeth Wellcome (2016-2016). Modelau niwroffisiolegol a dosbarthiad dysgu peirianyddol o ddeinameg osgiliadoliaeth cyflwr gorffwys a gorffwys mewn sgitsoffrenia. Singh, Walters, Freeman, Zhang.
£321,794 gan Ymddiriedolaeth Wellcome. (2013-2016). Cydbwysedd cyffrous-ataliol mewn pobl ifanc sydd â risg genetig uchel o anhwylder meddwl: Astudiaeth o osgiliadau gama cortical a chrynodiadau GABA o syndrom dileu 22q11.2. Doherty, Owen. Linden, Van den Bree, Singh.
£4.2miliwn (FEC) (£925,580 i Singh fel Prif Swyddog Gweithredol Caerdydd) o'r MRC. (2013-2018). Diffinio'r aflonyddwch mewn glutamad cortical a swyddogaeth GABA mewn seicosis, ei darddiad a'i ganlyniadau. Deakin, Talbot, Gerhard, Hinz, Williams, Singh, Wilkinson, Walters, Freeman, Morris, Liddle, Brookes, Palaniyappan, Macdonald.
£1.5miliwn (FEC) o'r MRC. (2013-2019). Adeiladu capasiti ymchwil glinigol aml-safle mewn Magnetoencephalography (MEG). Singh (PI), Hamandi, Gross, Kessler, Brookes, Morris, Henson, Barnes, Woolrich, Nobre, Litvak, Holliday, Furlong, Shtyrov, Green
£986,846 (FEC) o'r MRC. (2013-2016). Effeithiau ymddygiadol a niwroffisiolegol genynnau risg sgitsoffrenia: dull aml-locws, seiliedig ar lwybr. Linden, O'Donovan, Owen, Holmans, Pocklington, Zammit, Hall, Singh, Jones, Davey-Smith.
£668,226 iYmddiriedolaeth Wellcome. (2013-2018). Seilwaith cyfrifiadurol pwrpasol ar gyfer CUBRIC. Jones, Singh, Doeth.
£99,980 gan Epilepsy Research UK. (2010-2013). Mesurau magnetoencephalograffig osgiliadau synhwyraidd annormal: Ffenestr newydd ar epilepsi ffotosensitif . Hamandi, Singh a Muthukumaraswamy.
£15,000 gan Gymdeithas Anesthetyddion Prydain Fawr ac Iwerddon. (2013-2014). Deall mecanweithiau sedation: Effeithiau tawelyddion GABAergic ac an-GABAergig ar ymatebion gamma gweledol magnetoencephalograffig. Neuadd, Doeth, Singh.
£195,000 gan Lywodraeth Cynulliad Cymru (A4B). (2010-2013). Y Prosiect Delweddu ac Ysgogi Ymennydd Integredig (IBIS). Chambers, Singh, Wise, Jones a Jiles.
£146,543 gan Ymddiriedolaeth Wellcome. (2011-2018). Niwrowyddoniaeth Integredig. Wise a Singh.
£165,000 gan Bryste Research into Alzheimer's and Care of the Elderly. (2010-2013). Nodweddu uniondeb swyddogaethol ac anatomegol prosesu sy'n gysylltiedig â sylw gweledol mewn Alzheimer's clefyd. Straeon, Singh, Bayer, Jones ac O'Sullivan.
£113,039 gan Sefydliad Waterloo. (2010-2013). Niwro-ddelweddu Uwch yn BECTS. Hamandi, Singh, et al.
£426,191 gan Ymddiriedolaeth Wellcome. (2009-2012). See it, grab it: Control of automatic sensorimotor behaviour in health and disease. Sumner, Husain, Singh a Rafal.
£69,148 gan MedTel Ltd. (2009-2012). Defnyddio'r Sganiwr MRI 3T, Wise, Jones, Singh.
£4miliwn gan Ymddiriedolaeth Wellcome. (2008-2014). Rhaglen PhD 4 mlynedd mewn niwrowyddoniaeth integreiddiol. . Prif Ymgeiswyr: Aggleton a Crunelli.
£176,933 gan BBSRC (BBSB08035). (2004-2007). Astudiaethau Magnetometreg Agorfa Synthetig o Newidiadau Pŵer Osgiliadoliaeth Cysylltiedig ag Ysgogiad mewn Gweledol Dynol Cortex. Singh.

Rwy'n arweinydd modiwl ar gyfer modiwl Israddedig blwyddyn olaf, PS3214: "Cyflwyniad i Ddulliau a Chymwysiadau Niwroddelweddu". Mae hwn yn gwrs sydd wedi'i gynllunio i roi cipolwg i fyfyrwyr ar yr egwyddorion y tu ôl i dechnegau niwroddelweddu anfewnwthiol modern a'u cymhwyso mewn niwrowyddoniaeth wybyddol a chlinigol. Mae'r pynciau dan sylw yn cynnwys: Egwyddorion MRI a delweddu strwythurol, DTI, fMRI, TMS, TDCS, niwroffisioleg, EEG ac MEG, seicosis, iselder, dementia a niwroleg.

Addysg israddedig

1984 – 1987: Coleg Collingwood, Prifysgol Durham. BSc (Anrh) mewn Ffiseg

Addysg ôl-raddedig

1987 – 1991: Adran Ffiseg, Y Brifysgol Agored, Milton Keynes. PhD mewn Ffiseg.

Cyflogaeth

2000 - 2005: Uwch Ddarlithydd, Ysgol Gwyddorau Bywyd ac Iechyd, Prifysgol Aston.

1998 - 2000: Darlithydd. MARIARC, Ysgol Meddygaeth, Prifysgol Lerpwl.

1996 - 1998: Cymrawd Ymchwil. Seicoleg, Coleg Brenhinol Holloway, Prifysgol Llundain.

1992 - 1996: Cymrawd Ymchwil. Adran Gwyddorau Gweledigaeth, Prifysgol Aston, Birmingham.

1991 - 1992: Cymrawd Ymchwil. Adran Ffiseg, Y Brifysgol Agored, Milton Keynes.

Diddordebau ymchwil ôl-raddedig

Mae gen i ddiddordeb mewn goruchwylio prosiectau PhD mewn dulliau a chymwysiadau niwrodelweddu swyddogaethol aml-foddol (MEG a fMRI), gyda ffocws penodol ar weledigaeth a niwroffisioleg sylfaenol signalau MEG a BOLD-fMRI. Diddordeb datblygol diweddar oedd dibyniaeth y mesurau hyn ar ataliad GABAergig.

Os oes gennych ddiddordeb mewn gwneud cais am PhD, neu am ragor o wybodaeth ynglŷn â'm hymchwil ôl-raddedig, cysylltwch â mi yn uniongyrchol (manylion cyswllt ar gael ar y dudalen 'Trosolwg'), neu cyflwynwch gais ffurfiol.

Goruchwyliaeth gyfredol

Rebecca Taylor

Eloise Crossman

Prosiectau'r gorffennol

Myfyrwyr Ôl-raddedig Cyfredol Rwy'n goruchwylio neu'n cyd-oruchwylio:

Elena Stylianopolou 2023-

Jake Bussell 2023-

Rebecca Taylor 2023-

Hannah Thomas 2023-

Jiří Benáček 2022-

Rebecca Oates 2023-

Heather Statham 2023-

Eloise Crossman 2023-

Stefan Brugger 2017-

Myfyrwyr Blaenorol

Jacopo Barone 2018-2023

Ms Emily Lambe 2018-2020

Mr Alexander Shaw 2011-2015

Mr Panagiotis Kovanis 2010-2014

Ms Sian Robson (née Griffiths) 2010-2013

Mr Benjamin Dunkley 2008-2011

Mr Ian Fawcett 2002-2005

Ms Claire Hanley 2012-2015

Ms Jennifer Brealy 2011-2015

Ms Laura Whitlow 2012-2015

Mr Mark Mikkelsen 2012-2013

Mr Lorenzo Magazzini 2013-2017

Mr Kacper Wieczorek, 2013-2016

Ms Bethany Routley 2013-2017

Dr Gemma Williams 2014-2018

Ms Diana Dima 2015-2019

Ms Rachael Stickland 2015-2019

Ms Phoebe Asquith 2015-2019

Dr Joanne Doherty 2013-2019

Ms Megan Godfrey 2016-2020

Ms Laura Bloomfield 2016-2020

Ms Melissa Wright 2016-2020

Ms Marie-Lucie Reed 2017-2021

Mr Tom Chambers 2017-2021

Mr Dominik Krzeminski 2018-2021

Contact Details

SinghKD@caerdydd.ac.uk
+44 29208 74690
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ

Themâu ymchwil

Arbenigeddau

Magnetoencephalograffeg
Niwroddelweddu
Modelu niwrolegol
electroffisioleg

Yr Athro Krish Singh (e/fe) BSc Dunelm, PhD Open