Professor Rachel Errington

2023

• Ahmad, F., Soe, S., Albon, J., Errington, R. and Theobald, P. 2023. Quantifying the microstructural and biomechanical changes in the porcine ventricles during growth and remodelling. Acta Biomaterialia 171, pp. 166-192. (10.1016/j.actbio.2023.09.044)
• Dumcius, P. et al. 2023. Dual-wave acoustofluidic centrifuge for ultrafast concentration of nanoparticles and extracellular vesicles (small 35/2023). Small 19(35), article number: 2370274. (10.1002/smll.202370274)
• Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19(35), article number: 2300390. (10.1002/smll.202300390)

2021

• de Almeida, A., Parthimos, D., Dew, H., Smart, O., Wiltshire, M. and Errington, R. J. 2021. Aquaglyceroporin-3’s expression and cellular localization is differentially modulated by hypoxia in prostate cancer cell lines. Cells 10(4), article number: 838. (10.3390/cells10040838)
• Evans, L., Milward, K., Attanoos, R., Clayton, A., Errington, R. and Tabi, Z. 2021. Macrophage plasticity and function in the lung tumour microenvironment revealed in 3D heterotypic spheroid and explant models. Biomedicines 9(3), article number: 302. (10.3390/biomedicines9030302)
• Edmunds, G. L. et al. 2021. Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study. Canine Medicine and Genetics 8, article number: 2. (10.1186/s40575-021-00100-7)

2020

• Karuna, A. et al. 2020. Quantitative imaging of B1 cyclin expression across the cell cycle using green fluorescent protein tagging and epi-fluorescence. Cytometry Part A 97(10), pp. 1066-1072. (10.1002/cyto.a.24038)
• Moses, R. L. et al. 2020. Novel epoxy-tiglianes stimulate skin keratinocyte wound healing responses and re-epithelialization via protein kinase C activation. Biochemical Pharmacology 178, article number: 114048. (10.1016/j.bcp.2020.114048)
• Xu, L. et al. 2020. Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling. Journal of Extracellular Vesicles 9(1), article number: 1779458. (10.1080/20013078.2020.1779458)
• Mikhaylov, R. et al. 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20(10), pp. 1807-1814. (10.1039/C9LC01192G)

2019

• Icha, J., Nedbal, J., Leavesley, S., Weber, M., Ivaska, J., Errington, R. and Niesner, R. 2019. Phototoxicity in live fluorescence imaging understanding, quantifying and minimizing it. Cytometry Part A 95(6), pp. 634-636. (10.1002/cyto.a.23777)
• Karuna, A., Masia, F., Wiltshire, M., Errington, R., Borri, P. and Langbein, W. 2019. Label-free volumetric quantitative imaging of human osteosarcoma cells by hyperspectral coherent anti-Stokes Raman scattering. Presented at: SPIE BIOS, San Francisco, California, US, 2-7 Feb 2019Multiphoton Microscopy in the Biomedical Sciences XIX, Vol. 10882. Proceedings of SPIE Bellingham, Washington: SPIE pp. 108821P., (10.1117/12.2510277)
• Karuna, A., Masia, F., Wiltshire, M., Errington, R., Borri, P. and Langbein, W. 2019. Label-free volumetric quantitative imaging of the human somatic cell division by hyperspectral coherent anti-Stokes Raman scattering. Analytical Chemistry 91(4), pp. 2813-2821. (10.1021/acs.analchem.8b04706)

2018

• Jordan, L. A. et al. 2018. Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis. Rheumatology 57(11), pp. 2042-2052. (10.1093/rheumatology/key196)
• Johnson, C. E. et al. 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37, pp. 5913-5925. (10.1038/s41388-018-0381-2)
• McCann, H., Johnson, C., Errington, R., Davies, D. M., Dunlop, E. and Tee, A. 2018. Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment. Cancers 10(10), pp. -., article number: 375. (10.3390/cancers10100375)
• Smith, P. J., Darzynkiewicz, Z. and Errington, R. J. 2018. Nuclear cytometry and chromatin organization. Cytometry Part A 93(8), pp. 771-784. (10.1002/cyto.a.23521)
• Stephens, N., Khan, I. and Errington, R. 2018. Analysing the role of virtualisation and visualisation on interdisciplinary knowledge exchange in stem cell research processes. Palgrave Communications 4(1), pp. -., article number: 78. (10.1057/s41599-018-0126-4)
• Yeung, V. et al. 2018. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma. Nanoscale 10(18), pp. 8547-8559. (10.1039/C8NR02417K)
• Errington, R. J. et al. 2018. Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones. Bioorganic and Medicinal Chemistry Letters 28(8), pp. 1274-1277. (10.1016/j.bmcl.2018.03.040)

2017

• Nesbitt, H., Worthington, J., Errington, R., Patterson, L. H., Smith, P. J., McKeown, S. R. and McKenna, D. J. 2017. The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors. Prostate 77(15), pp. 1539-1547. (10.1002/pros.23434)
• Nesbitt, H. et al. 2017. Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant progression. Clinical Cancer Research 23(7), pp. 1797-1808. (10.1158/1078-0432.CCR-16-1361)
• Dunlop, E. A., Johnson, C., Wiltshire, M., Errington, R. J. and Tee, A. 2017. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively. Oncotarget (10.18632/oncotarget.16232)
• Pretorius, A. J., Khan, I. A. and Errington, R. J. 2017. A survey of visualization for live cell imaging. Computer Graphics Forum 36(1), pp. 46-63. (10.1111/cgf.12784)

2015

• Colombo, J. S., Howard-Jones, R. A., Young, F. I., Waddington, R. J., Errington, R. J. and Sloan, A. J. 2015. A 3D ex vivo mandible slice system for longitudinal culturing of transplanted dental pulp progenitor cells. Cytometry Part A 87(10), pp. 921-928. (10.1002/cyto.a.22680)

2014

• Khan, I., Fraser, A., Bray, M., Smith, P. J., White, N. S., Carpenter, A. E. and Errington, R. 2014. ProtocolNavigator: emulation-based software for the design, documentation and reproduction biological experiments. Bioinformatics 30(23), pp. 3440-3442. (10.1093/bioinformatics/btu554)
• Johnson, C. et al. 2014. Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine. Molecular Oncology 9(3), pp. 675-688. (10.1016/j.molonc.2014.11.005)

2013

• Colmont, C. S., Ben Ketah, A., Errington, R. J., Reed, S. H., Udey, M. C. and Patel, G. K. 2013. Human basal cell carcinoma tumor-initiating cells are resistant to etoposide [Letter]. Journal of Investigative Dermatology 134(3), pp. 867-870. (10.1038/jid.2013.377)
• Al-Saraireh, Y. et al. 2013. Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration. PLoS ONE 8(8), pp. e73366. (10.1371/journal.pone.0073366)
• Mart, R. J. et al. 2013. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells. Molecular BioSystems 9(11), pp. 2597-2603. (10.1039/c3mb70246d)
• Smith, P., Falconer, R. and Errington, R. 2013. Micro-community cytometry: sensing changes in cell health and glycoconjugate expression by imaging and flow cytometry. Journal of Microscopy 251(2), pp. 113-122. (10.1111/jmi.12060)
• Errington, R. J., Chappell, S. C., Khan, I. A., Marquez Almuina, N., Wiltshire, M., Griesdoorn, V. D. and Smith, P. J. 2013. Time-lapse microscopy approaches to track cell cycle and lineage progression at the single-cell level. Current Protocols in Cytometry 64(12.4) (10.1002/0471142956.cy1204s64)
• Becker, H. et al. 2013. Multivariate analysis of apoptotic markers versus cell cycle phase in living human cancer cells by microfluidic cytometry. Proceedings of SPIE 8615, pp. 86150W. (10.1117/12.2001474)
• Smith, P. J. et al. 2013. NCAM polysialylation during adherence transitions: live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7. Cytometry Part A 83A(7), pp. 659-671. (10.1002/cyto.a.22306)
• Akagi, J. et al. 2013. Real-time cell viability assays using a new anthracycline derivative DRAQ7®. Cytometry Part A 83A(2), pp. 227-234. (10.1002/cyto.a.22228)
• Smith, P. J., Wiltshire, M., Chappell, S. C., Cosentino, L., Burns, P. A., Pors, K. and Errington, R. J. 2013. Kinetic analysis of intracellular Hoechst 33342-DNA interactions by flow cytometry: misinterpretation of side population status?. Cytometry Part A 83A(1), pp. 161-169. (10.1002/cyto.a.22224)

2011

• Atari, M. I., Chappell, M. J., Errington, R. J., Smith, P. J. and Evans, N. D. 2011. Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport. Computer Methods and Programs in Biomedicine 104(2), pp. 93-103. (10.1016/j.cmpb.2010.06.008)
• Khan, I. A. et al. 2011. Interoperability of time series cytometric data: A cross platform approach for modeling tumor heterogeneity. Cytometry Part A 79A(3), pp. 214-226. (10.1002/cyto.a.21023)
• Rees, P., Brown, M. R., Summers, H. D., Holton, M. D., Errington, R. J., Chappell, S. C. and Smith, P. J. 2011. A transfer function approach to measuring cell inheritance. BMC Systems Biology 5, article number: 31. (10.1186/1752-0509-5-31)
• Fricke, T. et al. 2011. Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins. Bioconjugate Chemistry 22(9), pp. 1763-1767. (10.1021/bc200338u)
• Summers, H. D., Rees, P., Holton, M. D., Rowan Brown, M., Chappell, S. C., Smith, P. J. and Errington, R. J. 2011. Statistical analysis of nanoparticle dosing in a dynamic cellular system. Nature Nanotechnology 6(3), pp. 170-174. (10.1038/nnano.2010.277)

2010

• Johnstone, S. R., Best, A. K., Wright, C. S., Isakson, B. E., Errington, R. J. and Martin, P. E. 2010. Enhanced Connexin 43 Expression Delays Intra-Mitoitc Duration and Cell Cycle Traverse Independently of Gap Junction Channel Function. Journal of Cellular Biochemistry 110(3), pp. 772-782. (10.1002/jcb.22590)
• Brown, M. R., Summers, H. D., Rees, P., Smith, P. J., Chappell, S. C. and Errington, R. J. 2010. Flow-based cytometric analysis of cell cycle via simulated cell populations. PLOS Computational Biology 6(4), article number: e1000741. (10.1371/journal.pcbi.1000741)
• Errington, R. J. et al. 2010. Single cell nanoparticle tracking to model cell cycle dynamics and compartmental inheritance. Cell Cycle 9(1), pp. 121-130. (10.4161/cc.9.1.10246)
• Brown, M. R. et al. 2010. Long-term time series analysis of quantum dot encoded cells by deconvolution of the autofluorescence signal. Cytometry Part A 77A(10), pp. 925-932. (10.1002/cyto.a.20936)

2009

• Smith, P. J., Furon, E., Wiltshire, M., Campbell, L., Feeney, G. P., Snyder, R. D. and Errington, R. J. 2009. ABCG2-Associated Resistance to Hoechst 33342 and Topotecan in a Murine Cell Model with Constitutive Expression of Side Population Characteristics. Cytometry Part A 75A(11), pp. 924-933. (10.1002/cyto.a.20800)
• Johnstone, S. J., Wright, C. W., Errington, R. J. and Martin, P. E. 2009. Enhanced Connexin 43 expression mediates cell proliferation and migration independent of connexin mediated communication [Abstract]. Journal of Investigative Dermatology 129(S2), pp. S82. (10.1038/jid.2009.232)
• Holton, M. D., Silvestre, O., Errington, R. J., Smith, P. J., Matthews, D. R., Rees, P. and Summers, H. D. 2009. Stroboscopic fluorescence lifetime imaging. Optics Express 17(7), pp. 5205-5216. (10.1364/OE.17.005205)
• Smith, P. J., Khan, I. A. and Errington, R. J. 2009. Cytomics and cellular informatics - coping with asymmetry and heterogeneity in biological systems. Drug Discovery Today 14(5-6), pp. 271-277. (10.1016/j.drudis.2008.11.012)
• Smith, P. J., Errington, R. J., Summers, H. and Chappell, S. C. 2009. Microtrench and tumour proliferation assay. WO/2009/095666 [Patent].
• Silvestre, O., Holton, M. D., Summers, H. D., Smith, P. J. and Errington, R. J. 2009. Hollow fiber: a biophotonic implant for live cells. Presented at: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, San Jose, CA, USA, 26-28 January 2009 Presented at Farkas, D. L., Nicolau, D. V. and Leif, R. C. eds.Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII. Proceedings of the SPIE Vol. 7182. Bellingham, WA: SPIE, (10.1117/12.809391)

2008

• Smith, P. J., Wiltshire, M., Furon, E., Beattie, J. H. and Errington, R. J. 2008. Impact of overexpression of metallothionein-1 on cell cycle progression and zinc toxicity. American Journal of Physiology - Cell Physiology 295(5), pp. C1399-C1408. (10.1152/ajpcell.00342.2008)
• Smith, P. J. and Errington, R. J. 2008. Dissecting the Cell Cycle: Loss of Genomic Integrity and Escape from Senescence [Abstract]. Cytometry Part B Clinical Cytometry 74B(6), pp. 390. (10.1002/cyto.b.20462)
• Cheung, S. Y. A., Evans, N. D., Chappell, M. J., Godfrey, K. R., Smith, P. J. and Errington, R. J. 2008. Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling. Mathematical Biosciences 213(2), pp. 119-134. (10.1016/j.mbs.2008.03.008)
• Chappell, M. J. et al. 2008. A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine 89(2), pp. 169-178. (10.1016/j.cmpb.2007.11.002)
• Summers, H. D., Errington, R. J., Smith, P. J., Matthews, D. R. and Leary, J. F. 2008. Cytometric biochips with optically active surfaces for spatial engineering of fluorescence excitation. Presented at: Microfluidics, BioMEMS, and Medical Microsystems VI, San Jose, CA, USA, 21-22 January 2008 Presented at Wang, W. and Vauchier, C. eds.Microfluidics, BioMEMS, and Medical Microsystems VI (Proceedings Volume). Proceedings of the SPIE Vol. 6886. Bellingham, WA: SPIE, (10.1117/12.763645)
• Vojnovic, B., Barber, P., Pope, I., Smith, P. J. and Errington, R. J. 2008. Detecting objects. WO/2008/090330 [Patent].
• Smith, P. J., Patterson, L. and Errington, R. J. 2008. Gel formulations and uses thereof. 20080182287 [Patent].
• Summers, H. D., Errington, R. J., Smith, P. J., Chappell, S. C., Rees, P., Brown, M. R. and Leary, J. F. 2008. Cell-population tracking using quantum dots in flow cytometry. Presented at: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, San Jose, CA, USA, 21-23 February 2008 Presented at Cartwright, A. N. and Nicolau, D. V. eds.Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V. Proceedings of the SPIE Vol. 6865. Bellingham, WA: SPIE pp. 68650L., (10.1117/12.763602)

2007

• Smith, P. J. et al. 2007. Mitotic bypass via an occult cell cycle phase following DNA topoisomerase II inhibition in p53 functional human tumor cells. Cell Cycle 6(16), pp. 2071-2081. (10.4161/cc.6.16.4585)
• Khan, I. A., Husemann, P., Campbell, L., White, N. S., White, R. J., Smith, P. J. and Errington, R. J. 2007. ProgeniDB - A novel cell lineage database for generation associated phenotypic behavior in cell-based assays. Cell Cycle 6(7), pp. 868-874. (10.4161/cc.6.7.4045)
• Morris, D. et al. 2007. Development of an optical biochip for the analysis of cell environment sensitivity. Presented at: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, San Jose, CA, USA, 20 January 2007 Presented at Farkas, D. L., Leif, R. C. and Nicolau, D. V. eds.Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V. Proceedings of SPIE Vol. 6441. Bellingham, WA: SPIE pp. 64410V., (10.1117/12.700052)
• Matthews, D. R. et al. 2007. A fluorescence biochip with a plasmon active surface. Presented at: Plasmonics in Biology and Medicine IV, San Jose, CA, USA, 20 January 2007 Presented at Vo-Dinh, T. and Lakowicz, J. R. eds.Plasmonics in Biology and Medicine IV. Proceedings of SPIE Vol. 6450. Bellingham, WA: SPIE pp. 645006., (10.1117/12.698948)
• Njoh, K. et al. 2007. Live cell tracking on an optical biochip platform. Presented at: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, San Jose, CA, USA, 20 January 2007 Presented at Farkas, D. L., Leif, R. C. and Nicolau, D. V. eds.Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V. Proceedings of SPIE Vol. 6441. Bellingham, WA: SPIE pp. 64410X., (10.1117/12.698935)
• Chong, E. Z., Matthews, D. R., Summers, H. D., Njoh, K., Errington, R. J. and Smith, P. J. 2007. Development of FRET-Based assays in the Far-Red using CdTe quantum dots. Journal of Biomedicine and Biotechnology 2007, article number: 54169. (10.1155/2007/54169)

2006

• Njoh, K. L. et al. 2006. Spectral analysis of the DNA targeting bisalkylaminoanthraquinone DRAQ5 in intact living cells. Cytometry Part A 69A(8), pp. 805-814. (10.1002/cyto.a.20308)
• Matthews, D. R. et al. 2006. Technique for Measurement of Fluorescence Lifetime by use of Stroboscopic Excitation and Continuous-Wave Detection. Applied Optics 45(9), pp. 2115-2123. (10.1364/AO.45.002115)

2005

• Errington, R. J., Ameer-Beg, S. M., Vojnovic, B., Patterson, L. H., Zloh, M. and Smith, P. J. 2005. Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells. Advanced Drug Delivery Reviews 57(10), pp. 153-167. (10.1016/j.addr.2004.05.005)
• White, N. and Errington, R. J. 2005. Fluorescence techniques for drug delivery research: theory and practice. Advanced Drug Delivery Reviews 57(1), pp. 17-42. (10.1016/j.addr.2004.08.003)

2004

• Hughes, A., Errington, R. J., Fricker-Gates, R. and Jones, L. 2004. Endophilin A3 forms filamentous structures that colocalise with microtubules but not with actin filaments. Molecular Brain Research 128(2), pp. 182-192. (10.1016/j.molbrainres.2004.06.016)
• Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
• Marquez, N., Chappell, S. C., Sansom, O. J., Clarke, A. R., Teesdale-Spittle, P., Errington, R. J. and Smith, P. J. 2004. Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle 3, pp. 662-671.

2003

• Marquez, N., Chappell, S. C., Sansom, O. J., Clarke, A. R., Errington, R. J., Smith, P. J. and Court, J. 2003. Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint. Oncogene 22(48), pp. 7642-7648. (10.1038/sj.onc.1206876)

2002

• Baker, H. L., Errington, R. J., Davies, S. C. and Campbell, A. K. 2002. A mathematical model predicts that calreticulin interacts with the endoplasmic reticulum Ca2+-ATPase. Biophysical journal 82, pp. 582-590.
• Oviedo-Orta, E., Errington, R. J. and Evans, W. H. 2002. Gap junction intercellular communication during lymphocyte transendothelial migration. Cell Biology International 26(3), pp. 253-263. (10.1006/cbir.2001.0840)

2001

• Martin, P., Blundell, G., Ahmad, S., Errington, R. J. and Evans, W. H. 2001. Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels. Journal of Cell Science 114(21), pp. 3845-3855.

2000

• Smith, P. J. et al. 2000. Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy. Cytometry 40(4), pp. 280-291. (10.1002/1097-0320(20000801)40:4<280::AID-CYTO4>3.0.CO;2-7)