![Renata Jurkowska](https://profiles-cardiff.imgix.net/attachments/1086?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Renata Jurkowska
Senior Research Fellow
School of Biosciences
- JurkowskaR@cardiff.ac.uk
- +44 29208 79067
- Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
- Available for postgraduate supervision
Overview
I have always been fascinated by the processes of cellular differentiation and functional specialization, which illustrate how the genetic alphabet can elegantly be interpreted by an interplay of epigenetic processes to drive progenitor cells towards their specialized fates. This amazement has fueled the development and crystallization of my research interests around epigenetics and stem cell differentiation.
My long-term research interests are to understand how different populations of human lung cells cooperate to form a functional organ, how epigenetic regulation drives cellular identity in the healthy lung and how dysregulation of epigenetic processes due to environmental insults, like cigarette smoke or air pollution contributes to development of lung diseases.
Publication
2023
- Schwartz, U. et al. 2023. High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD. The EMBO Journal 42, article number: e111272. (10.15252/embj.2022111272)
- Dordevic, M. et al. 2023. EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells. Frontiers in Endocrinology 14, article number: 1134478. (10.3389/fendo.2023.1134478)
2022
- Pohl, S. T., Prada, M. L., Espinet, E. and Jurkowska, R. 2022. Practical considerations for complex tissue dissociation for single-cell transcriptomics. In: Calogero, R. and Benes, V. eds. Single Cell Transcriptomics. Methods in Molecular Biology., Vol. 2584. New York: Springer, pp. 371-387., (10.1007/978-1-0716-2756-3_19)
- Jurkowska, R. Z. and Jeltsch, A. 2022. Enzymology of mammalian DNA methyltransferases. In: Jeltsch, A. and Jurkowska, R. Z. eds. DNA Methyltransferases - Role and Function., Vol. 1389. Advances in Experimental Medicine and Biology Springer, pp. 69-110., (10.1007/978-3-031-11454-0_4)
- Jurkowska, R. Z. and Jeltsch, A. 2022. Mechanisms and biological roles of DNA methyltransferases and DNA methylation: From past achievements to future challenges. In: Jeltsch, A. and Jurkowska, R. Z. eds. DNA Methyltransferases - Role and Function., Vol. 1389. Advances in Experimental Medicine and Biology Springer, pp. 1-19., (10.1007/978-3-031-11454-0_1)
- Ravichandran, M. et al. 2022. Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function. Science Advances 8(36) (10.1126/sciadv.abm2427)
2021
- Prada, M. L. et al. 2021. Versatile workflow for cell-type resolved transcriptional and epigenetic profiles from cryopreserved human lung. JCI Insight 6(5), article number: e140443. (10.1172/jci.insight.140443)
2020
- Al-Amri, M. and Jurkowska, R. eds. 2020. Proceedings of Cardiff Institute for Tissue Engineering & Repair annual scientific meeting (CITER ASM 2020). Cardiff: CITER & Cardiff University.
- Ogger, P. P., Silva, J. D., Aghapour, M., Persson, I. M., Tulen, C., Jurkowska, R. and Ubags, N. D. 2020. Early Career Members at the ERS Lung Science Conference 2020: metabolic alterations in lung ageing and disease. Breathe 16(3), article number: 200063. (10.1183/20734735.0063-2020)
- Gao, L. et al. 2020. Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nature Communications 11, article number: 3355. (10.1038/s41467-020-17109-4)
2019
- Serçin, ?. et al. 2019. A solid-phase transfection platform for arrayed CRISPR screens. Molecular Systems Biology 15(12), article number: e8983. (10.15252/msb.20198983)
2018
- Rajavelu, A. et al. 2018. Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Research 46(17), pp. 9044–9056. (10.1093/nar/gky715)
- Emperle, M., Dukatz, M., Kunert, S., Holzer, K., Rajavelu, A., Jurkowska, R. Z. and Jeltsch, A. 2018. The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes. Scientific Reports 8(1), pp. -., article number: 13242. (10.1038/s41598-018-31635-8)
- Emperle, M., Rajavelu, A., Kunert, S., Arimondo, P. B., Reinhardt, R., Jurkowska, R. Z. and Jeltsch, A. 2018. The DNMT3A R882H mutant displays altered flanking sequence preferences. Nucleic Acids Research 46(6), pp. 3130-3139. (10.1093/nar/gky168)
- Ravichandran, M., Jurkowska, R. and Jurkowski, T. 2018. Target specificity of mammalian DNA methylation and demethylation machinery. Organic and Biomolecular Chemistry(9), pp. 1419-1435. (10.1039/C7OB02574B)
2017
- Jurkowska, R. Z. et al. 2017. H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1. Nature Communications 8, article number: 2057. (10.1038/s41467-017-02259-9)
- Stepper, P. et al. 2017. Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase. Nucleic Acids Research 45(4), pp. 1703-1713. (10.1093/nar/gkw1112)
2016
- Jurkowska, R. Z. and Jeltsch, A. 2016. Mechanisms and biological roles of DNA methyltransferases and DNA methylation: From past achievements to future challenges. Advances in Experimental Medicine and Biology 945, pp. 1-17. (10.1007/978-3-319-43624-1_1)
- Jurkowska, R. Z. and Jeltsch, A. 2016. Enzymology of mammalian DNA methyltransferases. Advances in Experimental Medicine and Biology 945, pp. 87-122. (10.1007/978-3-319-43624-1_5)
- Jeltsch, A. and Jurkowska, R. Z. 2016. Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm. Nucleic Acids Research 44(18), pp. 8556-8575. (10.1093/nar/gkw723)
2015
- Lungu, C., Muegge, K., Jeltsch, A. and Jurkowska, R. Z. 2015. An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric Heterochromatin. Journal of Molecular Biology 427(10), pp. 1903-1915. (10.1016/j.jmb.2015.03.014)
2014
- Kungulovski, G. et al. 2014. Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Research 24(11), pp. 1842-1853. (10.1101/gr.170985.113)
- Emperle, M., Rajavelu, A., Reinhardt, R., Jurkowska, R. Z. and Jeltsch, A. 2014. Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase. Journal of Biological Chemistry 289(43), pp. 29602-29613. (10.1074/jbc.M114.572032)
- Jeltsch, A. and Jurkowska, R. Z. 2014. New concepts in DNA methylation. Trends in Biochemical Sciences 39(7), pp. 310-318. (10.1016/j.tibs.2014.05.002)
- Bashtrykov, P., Jankevicius, G., Jurkowska, R. Z., Ragozin, S. and Jeltsch, A. 2014. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. Journal of Biological Chemistry 289(7), pp. 4106-4116. (10.1074/jbc.M113.528893)
2013
- Jurkowska, R. Z. and Jeltsch, A. 2013. Genomic imprinting-the struggle of the genders at the molecular level. Angewandte Chemie International Edition 52(51), pp. 13524-13536. (10.1002/anie.201307005)
- Jeltsch, A. and Jurkowska, R. Z. 2013. Multimerization of the Dnmt3a DNA methyltransferase and its functional implications. Progress in Molecular Biology and Translational Science 117, pp. 445-464. (10.1016/B978-0-12-386931-9.00016-7)
2012
- Siddique, A. N. et al. 2012. Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. Journal of Molecular Biology 425(3), pp. 479—491. (10.1016/j.jmb.2012.11.038)
- Bashtrykov, P., Jankevicius, G., Smarandache, A., Jurkowska, R., Ragozin, S. and Jeltsch, A. 2012. Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chemistry and Biology 19(5), pp. 572-578. (10.1016/j.chembiol.2012.03.010)
- Halby, L. et al. 2012. Rapid synthesis of new DNMT inhibitors derivatives of procainamide. ChemBioChem 13(1), pp. 157-165. (10.1002/cbic.201100522)
2011
- Jurkowska, R. Z., Jurkowski, T. P. and Jeltsch, A. 2011. Structure and function of mammalian DNA methyltransferases. ChemBioChem 12(2), pp. 206—222. (10.1002/cbic.201000195)
- Jurkowska, R. Z., Ceccaldi, A., Zhang, Y., Arimondo, P. B. and Jeltsch, A. 2011. DNA methyltransferase assays. In: Epigenetics Protocols., Vol. 791. Methods in Molecular Biology Humana Press, pp. 157-177., (10.1007/978-1-61779-316-5_13)
- Jurkowska, R. Z. et al. 2011. Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules. Journal of Biological Chemistry 286(27), pp. 24200-24207. (10.1074/jbc.M111.254987)
- Jurkowska, R. Z., Siddique, A. N., Jurkowski, T. P. and Jeltsch, A. 2011. Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase. ChemBioChem 12(10), pp. 1589—1594. (10.1002/cbic.201000673)
- Ceccaldi, A. et al. 2011. C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. ChemBioChem 12(9), pp. 1337-1345. (10.1002/cbic.201100130)
- Siddique, A. N., Jurkowska, R. Z., Jurkowski, T. P. and Jeltsch, A. 2011. Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS Journal 278(12), pp. 2055—2063. (10.1111/j.1742-4658.2011.08121.x)
- Rajavelu, A., Jurkowska, R. Z., Fritz, J. and Jeltsch, A. 2011. Function and disruption of DNA Methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Research 40(2), pp. 569–580. (10.1093/nar/gkr753)
2010
- Champion, C. et al. 2010. Mechanistic insights on the inhibition of C5 DNA methyltransferases by zebularine. PLoS ONE 5(8), article number: e12388. (10.1371/journal.pone.0012388)
- Dhayalan, A., Rajavelu, A., Rathert, P., Tamas, R., Jurkowska, R. Z., Ragozin, S. and Jeltsch, A. 2010. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and Guides DNA methylation. Journal of Biological Chemistry 285(34), pp. 26114-26120. (10.1074/jbc.M109.089433)
- Zhang, Y. et al. 2010. Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Research 38(13), pp. 4246–4253. (10.1093/nar/gkq147)
- Jurkowska, R. Z. and Jeltsch, A. 2010. Silencing of gene expression by targeted DNA methylation: concepts and approaches. In: Engineered Zinc Finger Proteins., Vol. 649. Humana Press, pp. 149-161., (10.1007/978-1-60761-753-2_9)
- Jeltsch, A. and Jurkowska, R. Z. 2010. DNA methylation. In: The Chemical Biology of Nucleic Acids. Wiley, pp. 307-301., (10.1002/9780470664001.ch14)
- Métivier, R. et al. 2010. Erratum: Cyclical DNA methylation of a transcriptionally active promoter. Nature 463(7279), article number: 384. (10.1038/nature08661)
2008
- Jurkowska, R. Z. et al. 2008. Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Research 36(21), pp. 6656–6663. (10.1093/nar/gkn747)
- Rathert, P. et al. 2008. Protein lysine methyltransferase G9a acts on non-histone targets. Nature Chemical Biology 4(6), pp. 344–346. (10.1038/nchembio.88)
- Métivier, R. et al. 2008. Cyclical DNA methylation of a transcriptionally active promoter. Nature 452(7183), pp. 45–50. (10.1038/nature06544)
2007
- Jia, D., Jurkowska, R. Z., Zhang, X., Jeltsch, A. and Cheng, X. 2007. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 449(7159), pp. 248–251. (10.1038/nature06146)
- Gallais, R. et al. 2007. Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Molecular Endocrinology -Baltimore- 21(9), pp. 2085–2098. (10.1210/me.2006-0490)
- Jeltsch, A., Jurkowska, R. Z., Jurkowski, T. P., Liebert, K., Rathert, P. and Schlickenrieder, M. 2007. Application of DNA methyltransferases in targeted DNA methylation. Applied Microbiology and Biotechnology 75(6), pp. 1233—1240. (10.1007/s00253-007-0966-0)
2006
- Gowher, H., Loutchanwoot, P., Vorobjeva, O., Handa, V., Jurkowska, R. Z., Jurkowski, T. P. and Jeltsch, A. 2006. Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. Journal of Molecular Biology 357(3), pp. 928—941. (10.1016/j.jmb.2006.01.035)
Articles
- Schwartz, U. et al. 2023. High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD. The EMBO Journal 42, article number: e111272. (10.15252/embj.2022111272)
- Dordevic, M. et al. 2023. EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells. Frontiers in Endocrinology 14, article number: 1134478. (10.3389/fendo.2023.1134478)
- Ravichandran, M. et al. 2022. Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function. Science Advances 8(36) (10.1126/sciadv.abm2427)
- Prada, M. L. et al. 2021. Versatile workflow for cell-type resolved transcriptional and epigenetic profiles from cryopreserved human lung. JCI Insight 6(5), article number: e140443. (10.1172/jci.insight.140443)
- Ogger, P. P., Silva, J. D., Aghapour, M., Persson, I. M., Tulen, C., Jurkowska, R. and Ubags, N. D. 2020. Early Career Members at the ERS Lung Science Conference 2020: metabolic alterations in lung ageing and disease. Breathe 16(3), article number: 200063. (10.1183/20734735.0063-2020)
- Gao, L. et al. 2020. Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nature Communications 11, article number: 3355. (10.1038/s41467-020-17109-4)
- Serçin, ?. et al. 2019. A solid-phase transfection platform for arrayed CRISPR screens. Molecular Systems Biology 15(12), article number: e8983. (10.15252/msb.20198983)
- Rajavelu, A. et al. 2018. Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Research 46(17), pp. 9044–9056. (10.1093/nar/gky715)
- Emperle, M., Dukatz, M., Kunert, S., Holzer, K., Rajavelu, A., Jurkowska, R. Z. and Jeltsch, A. 2018. The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes. Scientific Reports 8(1), pp. -., article number: 13242. (10.1038/s41598-018-31635-8)
- Emperle, M., Rajavelu, A., Kunert, S., Arimondo, P. B., Reinhardt, R., Jurkowska, R. Z. and Jeltsch, A. 2018. The DNMT3A R882H mutant displays altered flanking sequence preferences. Nucleic Acids Research 46(6), pp. 3130-3139. (10.1093/nar/gky168)
- Ravichandran, M., Jurkowska, R. and Jurkowski, T. 2018. Target specificity of mammalian DNA methylation and demethylation machinery. Organic and Biomolecular Chemistry(9), pp. 1419-1435. (10.1039/C7OB02574B)
- Jurkowska, R. Z. et al. 2017. H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1. Nature Communications 8, article number: 2057. (10.1038/s41467-017-02259-9)
- Stepper, P. et al. 2017. Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase. Nucleic Acids Research 45(4), pp. 1703-1713. (10.1093/nar/gkw1112)
- Jurkowska, R. Z. and Jeltsch, A. 2016. Mechanisms and biological roles of DNA methyltransferases and DNA methylation: From past achievements to future challenges. Advances in Experimental Medicine and Biology 945, pp. 1-17. (10.1007/978-3-319-43624-1_1)
- Jurkowska, R. Z. and Jeltsch, A. 2016. Enzymology of mammalian DNA methyltransferases. Advances in Experimental Medicine and Biology 945, pp. 87-122. (10.1007/978-3-319-43624-1_5)
- Jeltsch, A. and Jurkowska, R. Z. 2016. Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm. Nucleic Acids Research 44(18), pp. 8556-8575. (10.1093/nar/gkw723)
- Lungu, C., Muegge, K., Jeltsch, A. and Jurkowska, R. Z. 2015. An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric Heterochromatin. Journal of Molecular Biology 427(10), pp. 1903-1915. (10.1016/j.jmb.2015.03.014)
- Kungulovski, G. et al. 2014. Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Research 24(11), pp. 1842-1853. (10.1101/gr.170985.113)
- Emperle, M., Rajavelu, A., Reinhardt, R., Jurkowska, R. Z. and Jeltsch, A. 2014. Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase. Journal of Biological Chemistry 289(43), pp. 29602-29613. (10.1074/jbc.M114.572032)
- Jeltsch, A. and Jurkowska, R. Z. 2014. New concepts in DNA methylation. Trends in Biochemical Sciences 39(7), pp. 310-318. (10.1016/j.tibs.2014.05.002)
- Bashtrykov, P., Jankevicius, G., Jurkowska, R. Z., Ragozin, S. and Jeltsch, A. 2014. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. Journal of Biological Chemistry 289(7), pp. 4106-4116. (10.1074/jbc.M113.528893)
- Jurkowska, R. Z. and Jeltsch, A. 2013. Genomic imprinting-the struggle of the genders at the molecular level. Angewandte Chemie International Edition 52(51), pp. 13524-13536. (10.1002/anie.201307005)
- Jeltsch, A. and Jurkowska, R. Z. 2013. Multimerization of the Dnmt3a DNA methyltransferase and its functional implications. Progress in Molecular Biology and Translational Science 117, pp. 445-464. (10.1016/B978-0-12-386931-9.00016-7)
- Siddique, A. N. et al. 2012. Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. Journal of Molecular Biology 425(3), pp. 479—491. (10.1016/j.jmb.2012.11.038)
- Bashtrykov, P., Jankevicius, G., Smarandache, A., Jurkowska, R., Ragozin, S. and Jeltsch, A. 2012. Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chemistry and Biology 19(5), pp. 572-578. (10.1016/j.chembiol.2012.03.010)
- Halby, L. et al. 2012. Rapid synthesis of new DNMT inhibitors derivatives of procainamide. ChemBioChem 13(1), pp. 157-165. (10.1002/cbic.201100522)
- Jurkowska, R. Z., Jurkowski, T. P. and Jeltsch, A. 2011. Structure and function of mammalian DNA methyltransferases. ChemBioChem 12(2), pp. 206—222. (10.1002/cbic.201000195)
- Jurkowska, R. Z. et al. 2011. Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules. Journal of Biological Chemistry 286(27), pp. 24200-24207. (10.1074/jbc.M111.254987)
- Jurkowska, R. Z., Siddique, A. N., Jurkowski, T. P. and Jeltsch, A. 2011. Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase. ChemBioChem 12(10), pp. 1589—1594. (10.1002/cbic.201000673)
- Ceccaldi, A. et al. 2011. C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. ChemBioChem 12(9), pp. 1337-1345. (10.1002/cbic.201100130)
- Siddique, A. N., Jurkowska, R. Z., Jurkowski, T. P. and Jeltsch, A. 2011. Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS Journal 278(12), pp. 2055—2063. (10.1111/j.1742-4658.2011.08121.x)
- Rajavelu, A., Jurkowska, R. Z., Fritz, J. and Jeltsch, A. 2011. Function and disruption of DNA Methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Research 40(2), pp. 569–580. (10.1093/nar/gkr753)
- Champion, C. et al. 2010. Mechanistic insights on the inhibition of C5 DNA methyltransferases by zebularine. PLoS ONE 5(8), article number: e12388. (10.1371/journal.pone.0012388)
- Dhayalan, A., Rajavelu, A., Rathert, P., Tamas, R., Jurkowska, R. Z., Ragozin, S. and Jeltsch, A. 2010. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and Guides DNA methylation. Journal of Biological Chemistry 285(34), pp. 26114-26120. (10.1074/jbc.M109.089433)
- Zhang, Y. et al. 2010. Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Research 38(13), pp. 4246–4253. (10.1093/nar/gkq147)
- Métivier, R. et al. 2010. Erratum: Cyclical DNA methylation of a transcriptionally active promoter. Nature 463(7279), article number: 384. (10.1038/nature08661)
- Jurkowska, R. Z. et al. 2008. Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Research 36(21), pp. 6656–6663. (10.1093/nar/gkn747)
- Rathert, P. et al. 2008. Protein lysine methyltransferase G9a acts on non-histone targets. Nature Chemical Biology 4(6), pp. 344–346. (10.1038/nchembio.88)
- Métivier, R. et al. 2008. Cyclical DNA methylation of a transcriptionally active promoter. Nature 452(7183), pp. 45–50. (10.1038/nature06544)
- Jia, D., Jurkowska, R. Z., Zhang, X., Jeltsch, A. and Cheng, X. 2007. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 449(7159), pp. 248–251. (10.1038/nature06146)
- Gallais, R. et al. 2007. Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Molecular Endocrinology -Baltimore- 21(9), pp. 2085–2098. (10.1210/me.2006-0490)
- Jeltsch, A., Jurkowska, R. Z., Jurkowski, T. P., Liebert, K., Rathert, P. and Schlickenrieder, M. 2007. Application of DNA methyltransferases in targeted DNA methylation. Applied Microbiology and Biotechnology 75(6), pp. 1233—1240. (10.1007/s00253-007-0966-0)
- Gowher, H., Loutchanwoot, P., Vorobjeva, O., Handa, V., Jurkowska, R. Z., Jurkowski, T. P. and Jeltsch, A. 2006. Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. Journal of Molecular Biology 357(3), pp. 928—941. (10.1016/j.jmb.2006.01.035)
Book sections
- Pohl, S. T., Prada, M. L., Espinet, E. and Jurkowska, R. 2022. Practical considerations for complex tissue dissociation for single-cell transcriptomics. In: Calogero, R. and Benes, V. eds. Single Cell Transcriptomics. Methods in Molecular Biology., Vol. 2584. New York: Springer, pp. 371-387., (10.1007/978-1-0716-2756-3_19)
- Jurkowska, R. Z. and Jeltsch, A. 2022. Enzymology of mammalian DNA methyltransferases. In: Jeltsch, A. and Jurkowska, R. Z. eds. DNA Methyltransferases - Role and Function., Vol. 1389. Advances in Experimental Medicine and Biology Springer, pp. 69-110., (10.1007/978-3-031-11454-0_4)
- Jurkowska, R. Z. and Jeltsch, A. 2022. Mechanisms and biological roles of DNA methyltransferases and DNA methylation: From past achievements to future challenges. In: Jeltsch, A. and Jurkowska, R. Z. eds. DNA Methyltransferases - Role and Function., Vol. 1389. Advances in Experimental Medicine and Biology Springer, pp. 1-19., (10.1007/978-3-031-11454-0_1)
- Jurkowska, R. Z., Ceccaldi, A., Zhang, Y., Arimondo, P. B. and Jeltsch, A. 2011. DNA methyltransferase assays. In: Epigenetics Protocols., Vol. 791. Methods in Molecular Biology Humana Press, pp. 157-177., (10.1007/978-1-61779-316-5_13)
- Jurkowska, R. Z. and Jeltsch, A. 2010. Silencing of gene expression by targeted DNA methylation: concepts and approaches. In: Engineered Zinc Finger Proteins., Vol. 649. Humana Press, pp. 149-161., (10.1007/978-1-60761-753-2_9)
- Jeltsch, A. and Jurkowska, R. Z. 2010. DNA methylation. In: The Chemical Biology of Nucleic Acids. Wiley, pp. 307-301., (10.1002/9780470664001.ch14)
Books
- Al-Amri, M. and Jurkowska, R. eds. 2020. Proceedings of Cardiff Institute for Tissue Engineering & Repair annual scientific meeting (CITER ASM 2020). Cardiff: CITER & Cardiff University.
Teaching
Module contributor: BI2331 Physiology
Module contributor: BI2332 Concepts of Disease
Biography
Since September 2019 I am a Senior Lecturer in the Biomedicine Division within the School of Biosciences at Cardiff University, where I have a distinct pleasure to work in a highly collaborative and inspiring research environment.
After completing my BSc and MSc studies in Biotechnology at Warsaw University in Poland, I joined the group of Prof. Albert Jeltsch (Jacobs University Bremen, Germany) for PhD studies in Biochemistry, which I concluded with special distinction. I investigated the enzymatic properties and regulation of human DNA methyltransferases, key enzymes involved in cellular identity and function. My PhD triggered a long-life fascination with epigenetics and crystallised my research interests around stem cell differentiation and tissue regeneration. During my postdoctoral time (initially at Jacobs university Bremen, Germany and then at University of Stuttgart, Germany), I investigated the mechanisms of different classes of epigenetic enzymes to understand their function and contribution to human diseases.
I like exploring emerging fields and engaging in interdisciplinary projects. Therefore, after my postdoc, I chaned my research field from biochemistry to lung diseases and the research sector from academia to a start-up company. From the end of 2015 until July 2019 I was a project leader at the Epigenetics and COPD research team at BioMed X Innovation Center in Heidelberg (Germany), an institution promoting a novel collaboration model at the interface between academia and industry. There, I have designed and successfully delivered an innovative research project carried out in collaboration with pharma industry, which explored epigenetic regulation of chronic obstructive pulmonary disease to provide novel therapeutic avenues for this uncurable lung disease. The success of the project and its impact were demonstrated by the acquisition of all results by the pharma partner for internal continuation.
Honours and awards
- Best Oral Presentation Award at the Lung Science Conference (2020)
- Postdoctoral fellowship and research grant awarded by the Carl Zeiss Foundation (2015)
- EMBO short term fellowship award (2014)
- Best poster award at the 6th NEB meeting and workshop on “DNA restriction and modification”, Bremen, Germany (2010)
- Merit-based scholarship for distinguished scientific achievements granted by Polish Ministry of Education (2004-2003 and 2003-2002)
Scholarship granted for distinguished achievements, Warsaw University, Poland (2004-2000)
Professional memberships
- Member of the British Association for Lung Research (from 2019)
- Member of the European Respiratory Society (from 2016)
- Member of the American Thoracic Society (from 2016)
- Member of the The (German) Society for Biochemistry and Molecular Biology (from 2005)
Academic positions
- 2019 - present: Senior Lecturer, Cardiff University
- 2015 - 2019: Project Leader at BioMed X Innovation Center (Heidelberg, Germany)
- 2012 - 2019: Postdoctoral Researcher, Stuttgart University (Germany)
- 2009 - 2011: Postdoctoral Researcher, Jakobs University Bremen (Germany)
Committees and reviewing
- Member of the Editorial Board of Epigenomes (from 2018)
- Journal reviewer of diverse journals
Supervisions
I am interested in supervising PhD students in the areas of:
- lung biology
- epigenetics
- stem cells differentiation
- chronic lung diseases
